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Conserved domains on  [gi|1083527501|gb|OGG27493|]
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6-phosphogluconate dehydrogenase (decarboxylating) [Candidatus Gottesmanbacteria bacterium RIFCSPLOWO2_01_FULL_39_12b]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YqeC super family cl34065
6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];
9-276 1.30e-137

6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG1023:

Pssm-ID: 440646 [Multi-domain]  Cd Length: 300  Bit Score: 389.84  E-value: 1.30e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501   9 RSPDKLRDDRSIGkLTPCYNLNHLVNNLAPPRIIWLMVEHGKPVDEVIRELIKAgVTKGDIIIDGGNSFYKDSVKRHKFL 88
Cdd:COG1023    31 RNPEAVAALAAEG-ATGADSLEELVAKLPAPRVVWLMVPAGEITDQVIEELAPL-LEPGDIVIDGGNSNYKDDIRRAEEL 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501  89 KEKGINFLDMGTSGGLEGARNGACLMIGGEKNIYEKLVPLFQKL-IGTKGGYAYFGPAGAGHFVKMVHNGVEYGMLQAIG 167
Cdd:COG1023   109 AEKGIHFVDVGTSGGVWGLENGYCLMIGGDKEAVERLEPIFKALaPGAENGYLHCGPVGAGHFVKMVHNGIEYGMMQAYA 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501 168 EGFELLAKGPYDLNFHLISKNWNSGSVVRGWLMELLERALQKDPKLKSFSGIIGGGSTGEWTVETAKELEVKVPVIKESL 247
Cdd:COG1023   189 EGFELLEASEFDLDLAEVAEVWRRGSVIRSWLLDLTADALAEDPKLEGISGYVEDSGEGRWTVEEAIELGVPAPVITAAL 268

                         250       260
                  ....*....|....*....|....*....
gi 1083527501 248 DARKKSLDKPSFSGKVVAALRYQFGGHKV 276
Cdd:COG1023   269 FARFRSRQEDSFADKVLAALRNQFGGHAV 297
 
Name Accession Description Interval E-value
YqeC COG1023
6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];
9-276 1.30e-137

6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];


Pssm-ID: 440646 [Multi-domain]  Cd Length: 300  Bit Score: 389.84  E-value: 1.30e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501   9 RSPDKLRDDRSIGkLTPCYNLNHLVNNLAPPRIIWLMVEHGKPVDEVIRELIKAgVTKGDIIIDGGNSFYKDSVKRHKFL 88
Cdd:COG1023    31 RNPEAVAALAAEG-ATGADSLEELVAKLPAPRVVWLMVPAGEITDQVIEELAPL-LEPGDIVIDGGNSNYKDDIRRAEEL 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501  89 KEKGINFLDMGTSGGLEGARNGACLMIGGEKNIYEKLVPLFQKL-IGTKGGYAYFGPAGAGHFVKMVHNGVEYGMLQAIG 167
Cdd:COG1023   109 AEKGIHFVDVGTSGGVWGLENGYCLMIGGDKEAVERLEPIFKALaPGAENGYLHCGPVGAGHFVKMVHNGIEYGMMQAYA 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501 168 EGFELLAKGPYDLNFHLISKNWNSGSVVRGWLMELLERALQKDPKLKSFSGIIGGGSTGEWTVETAKELEVKVPVIKESL 247
Cdd:COG1023   189 EGFELLEASEFDLDLAEVAEVWRRGSVIRSWLLDLTADALAEDPKLEGISGYVEDSGEGRWTVEEAIELGVPAPVITAAL 268

                         250       260
                  ....*....|....*....|....*....
gi 1083527501 248 DARKKSLDKPSFSGKVVAALRYQFGGHKV 276
Cdd:COG1023   269 FARFRSRQEDSFADKVLAALRNQFGGHAV 297
PRK09599 PRK09599
NADP-dependent phosphogluconate dehydrogenase;
9-276 3.39e-134

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236582 [Multi-domain]  Cd Length: 301  Bit Score: 381.02  E-value: 3.39e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501   9 RSPDKLRDDRSIGkLTPCYNLNHLVNNLAPPRIIWLMVEHGKPVDEVIRELIKAgVTKGDIIIDGGNSFYKDSVKRHKFL 88
Cdd:PRK09599   31 RNPEAVEALAEEG-ATGADSLEELVAKLPAPRVVWLMVPAGEITDATIDELAPL-LSPGDIVIDGGNSYYKDDIRRAELL 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501  89 KEKGINFLDMGTSGGLEGARNGACLMIGGEKNIYEKLVPLFQKL-IGTKGGYAYFGPAGAGHFVKMVHNGVEYGMLQAIG 167
Cdd:PRK09599  109 AEKGIHFVDVGTSGGVWGLERGYCLMIGGDKEAVERLEPIFKALaPRAEDGYLHAGPVGAGHFVKMVHNGIEYGMMQAYA 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501 168 EGFELLAKGPYDLNFHLISKNWNSGSVVRGWLMELLERALQKDPKLKSFSGIIGGGSTGEWTVETAKELEVKVPVIKESL 247
Cdd:PRK09599  189 EGFELLEASRFDLDLAAVAEVWRRGSVIRSWLLDLTADALAEDPKLDEISGYVEDSGEGRWTVEEAIDLAVPAPVIAAAL 268

                         250       260
                  ....*....|....*....|....*....
gi 1083527501 248 DARKKSLDKPSFSGKVVAALRYQFGGHKV 276
Cdd:PRK09599  269 FMRFRSRQEDSFADKVVAALRNGFGGHAV 297
gnd_rel TIGR00872
6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) ...
 12-276 1.78e-99

6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) of bacterial and eukaryotic 6-phosphogluconate dehydrogenases but differs from it by a deep split in a UPGMA similarity clustering tree and the lack of a central region of about 140 residues. Among complete genomes, it is found is found in Bacillus subtilis and Mycobacterium tuberculosis, both of which also contain gnd, and in Aquifex aeolicus. The protein from Methylobacillus flagellatus KT has been characterized as a decarboxylating 6-phosphogluconate dehydrogenase as part of an unusual formaldehyde oxidation cycle. In some sequenced organisms members of this family are the sole 6-phosphogluconate dehydrogenase present and are probably active in the pentose phosphate cycle. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273313 [Multi-domain]  Cd Length: 298  Bit Score: 292.91  E-value: 1.78e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501  12 DKLRDDRSIGKLtpcyNLNHLVNNLAPPRIIWLMVEHGKpVDEVIRELiKAGVTKGDIIIDGGNSFYKDSVKRHKFLKEK 91
Cdd:TIGR00872  37 KAMKEDRTTGVA----NLRELSQRLSAPRVVWVMVPHGI-VDAVLEEL-APTLEKGDIVIDGGNSYYKDSLRRYKLLKEK 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501  92 GINFLDMGTSGGLEGARNGACLMIGGEKNIYEKLVPLFQKLIGTKGGYAYFGPAGAGHFVKMVHNGVEYGMLQAIGEGFE 171
Cdd:TIGR00872 111 GIHLLDCGTSGGVWGRERGYCFMIGGDGEAFARAEPLFADVAPEEQGYLYCGPCGSGHFVKMVHNGIEYGMMAAIAEGFE 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501 172 LLAKGPYDLNFHLISKNWNSGSVVRGWLMELLERALQKDPKLKSFSGIIGGGSTGEWTVETAKELEVKVPVIKESLDARK 251
Cdd:TIGR00872 191 ILRNSQFDFDIPEVARVWRRGSVIRSWLLDLTAIAFRESPDLAEFSGRVSDSGEGRWTVIAAIDLGVPAPVIATSLQSRF 270

                         250       260
                  ....*....|....*....|....*
gi 1083527501 252 KSLDKPSFSGKVVAALRYQFGGHKV 276
Cdd:TIGR00872 271 ASRDLDDFANKVLAALRKEFGGHAE 295
NAD_binding_2 pfam03446
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ...
 9-132 8.37e-35

NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.


Pssm-ID: 427298 [Multi-domain]  Cd Length: 159  Bit Score: 122.96  E-value: 8.37e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501   9 RSPDKLRDDRSIGkLTPCYNLNHLVNNLappRIIWLMVEHGKPVDEVI-RELIKAGVTKGDIIIDGGNSFYKDSVKRHKF 87
Cdd:pfam03446  30 RTPEKVEELVAAG-AIAAASPAEFVAGL---DVVITMVPAGAAVDAVIfGEGLLPGLKPGDIIIDGSTSSPEDARRRAKE 105

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1083527501  88 LKEKGINFLDMGTSGGLEGARNGAC-LMIGGEKNIYEKLVPLFQKL 132
Cdd:pfam03446 106 LKEKGLHFLDAPVSGGEAGAENGTLsIMVGGDEEAFERVKPILEAM 151
 
Name Accession Description Interval E-value
YqeC COG1023
6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];
9-276 1.30e-137

6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];


Pssm-ID: 440646 [Multi-domain]  Cd Length: 300  Bit Score: 389.84  E-value: 1.30e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501   9 RSPDKLRDDRSIGkLTPCYNLNHLVNNLAPPRIIWLMVEHGKPVDEVIRELIKAgVTKGDIIIDGGNSFYKDSVKRHKFL 88
Cdd:COG1023    31 RNPEAVAALAAEG-ATGADSLEELVAKLPAPRVVWLMVPAGEITDQVIEELAPL-LEPGDIVIDGGNSNYKDDIRRAEEL 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501  89 KEKGINFLDMGTSGGLEGARNGACLMIGGEKNIYEKLVPLFQKL-IGTKGGYAYFGPAGAGHFVKMVHNGVEYGMLQAIG 167
Cdd:COG1023   109 AEKGIHFVDVGTSGGVWGLENGYCLMIGGDKEAVERLEPIFKALaPGAENGYLHCGPVGAGHFVKMVHNGIEYGMMQAYA 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501 168 EGFELLAKGPYDLNFHLISKNWNSGSVVRGWLMELLERALQKDPKLKSFSGIIGGGSTGEWTVETAKELEVKVPVIKESL 247
Cdd:COG1023   189 EGFELLEASEFDLDLAEVAEVWRRGSVIRSWLLDLTADALAEDPKLEGISGYVEDSGEGRWTVEEAIELGVPAPVITAAL 268

                         250       260
                  ....*....|....*....|....*....
gi 1083527501 248 DARKKSLDKPSFSGKVVAALRYQFGGHKV 276
Cdd:COG1023   269 FARFRSRQEDSFADKVLAALRNQFGGHAV 297
PRK09599 PRK09599
NADP-dependent phosphogluconate dehydrogenase;
9-276 3.39e-134

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236582 [Multi-domain]  Cd Length: 301  Bit Score: 381.02  E-value: 3.39e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501   9 RSPDKLRDDRSIGkLTPCYNLNHLVNNLAPPRIIWLMVEHGKPVDEVIRELIKAgVTKGDIIIDGGNSFYKDSVKRHKFL 88
Cdd:PRK09599   31 RNPEAVEALAEEG-ATGADSLEELVAKLPAPRVVWLMVPAGEITDATIDELAPL-LSPGDIVIDGGNSYYKDDIRRAELL 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501  89 KEKGINFLDMGTSGGLEGARNGACLMIGGEKNIYEKLVPLFQKL-IGTKGGYAYFGPAGAGHFVKMVHNGVEYGMLQAIG 167
Cdd:PRK09599  109 AEKGIHFVDVGTSGGVWGLERGYCLMIGGDKEAVERLEPIFKALaPRAEDGYLHAGPVGAGHFVKMVHNGIEYGMMQAYA 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501 168 EGFELLAKGPYDLNFHLISKNWNSGSVVRGWLMELLERALQKDPKLKSFSGIIGGGSTGEWTVETAKELEVKVPVIKESL 247
Cdd:PRK09599  189 EGFELLEASRFDLDLAAVAEVWRRGSVIRSWLLDLTADALAEDPKLDEISGYVEDSGEGRWTVEEAIDLAVPAPVIAAAL 268

                         250       260
                  ....*....|....*....|....*....
gi 1083527501 248 DARKKSLDKPSFSGKVVAALRYQFGGHKV 276
Cdd:PRK09599  269 FMRFRSRQEDSFADKVVAALRNGFGGHAV 297
gnd_rel TIGR00872
6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) ...
 12-276 1.78e-99

6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) of bacterial and eukaryotic 6-phosphogluconate dehydrogenases but differs from it by a deep split in a UPGMA similarity clustering tree and the lack of a central region of about 140 residues. Among complete genomes, it is found is found in Bacillus subtilis and Mycobacterium tuberculosis, both of which also contain gnd, and in Aquifex aeolicus. The protein from Methylobacillus flagellatus KT has been characterized as a decarboxylating 6-phosphogluconate dehydrogenase as part of an unusual formaldehyde oxidation cycle. In some sequenced organisms members of this family are the sole 6-phosphogluconate dehydrogenase present and are probably active in the pentose phosphate cycle. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273313 [Multi-domain]  Cd Length: 298  Bit Score: 292.91  E-value: 1.78e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501  12 DKLRDDRSIGKLtpcyNLNHLVNNLAPPRIIWLMVEHGKpVDEVIRELiKAGVTKGDIIIDGGNSFYKDSVKRHKFLKEK 91
Cdd:TIGR00872  37 KAMKEDRTTGVA----NLRELSQRLSAPRVVWVMVPHGI-VDAVLEEL-APTLEKGDIVIDGGNSYYKDSLRRYKLLKEK 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501  92 GINFLDMGTSGGLEGARNGACLMIGGEKNIYEKLVPLFQKLIGTKGGYAYFGPAGAGHFVKMVHNGVEYGMLQAIGEGFE 171
Cdd:TIGR00872 111 GIHLLDCGTSGGVWGRERGYCFMIGGDGEAFARAEPLFADVAPEEQGYLYCGPCGSGHFVKMVHNGIEYGMMAAIAEGFE 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501 172 LLAKGPYDLNFHLISKNWNSGSVVRGWLMELLERALQKDPKLKSFSGIIGGGSTGEWTVETAKELEVKVPVIKESLDARK 251
Cdd:TIGR00872 191 ILRNSQFDFDIPEVARVWRRGSVIRSWLLDLTAIAFRESPDLAEFSGRVSDSGEGRWTVIAAIDLGVPAPVIATSLQSRF 270

                         250       260
                  ....*....|....*....|....*
gi 1083527501 252 KSLDKPSFSGKVVAALRYQFGGHKV 276
Cdd:TIGR00872 271 ASRDLDDFANKVLAALRKEFGGHAE 295
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 9-250 3.06e-67

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 215.71  E-value: 3.06e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501   9 RSPDK----LRDDRSIGKLTPCYNLNHLVNNLAPPRIIWLMVEHGKPVDEVIRELIKAgVTKGDIIIDGGNSFYKDSVKR 84
Cdd:COG0362    33 RTAEKtdafLAEHGKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPVDAVIEQLLPL-LEPGDIIIDGGNSHFTDTIRR 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501  85 HKFLKEKGINFLDMGTSGGLEGARNGACLMIGGEKNIYEKLVPLFQKlIGTK-GGY---AYFGPAGAGHFVKMVHNGVEY 160
Cdd:COG0362   112 EKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEA-IAAKvDGEpcvTYIGPDGAGHFVKMVHNGIEY 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501 161 GMLQAIGEGFELLAKGpydLNF-----HLISKNWNSGsVVRGWLMELLERAL-QKDPKL------------------Ksf 216
Cdd:COG0362   191 ADMQLIAEAYDLLRDG---LGLsndeiAEVFAEWNKG-ELDSYLIEITADILrKKDPETgkplvdvildkagqkgtgK-- 264

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1083527501 217 sgiigggstgeWTVETAKELEVKVPVIKESLDAR 250
Cdd:COG0362   265 -----------WTSQSALDLGVPLPLITEAVFAR 287
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
9-250 1.86e-66

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 213.83  E-value: 1.86e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501   9 RSPDK----LRDDRSIGKLTPCYNLNHLVNNLAPPRIIWLMVEHGKPVDEVIRELIKAgVTKGDIIIDGGNSFYKDSVKR 84
Cdd:PRK09287   21 RTPEKtdefLAEEGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPL-LEKGDIIIDGGNSNYKDTIRR 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501  85 HKFLKEKGINFLDMGTSGGLEGARNGACLMIGGEKNIYEKLVPLFQKlIGTK--GGY---AYFGPAGAGHFVKMVHNGVE 159
Cdd:PRK09287  100 EKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEK-IAAKveDGEpcvTYIGPDGAGHYVKMVHNGIE 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501 160 YGMLQAIGEGFELLAKGpydLNF-----HLISKNWNSGSvVRGWLMELLERAL-QKDPKL------------------Ks 215
Cdd:PRK09287  179 YGDMQLIAEAYDLLKDG---LGLsaeeiADVFAEWNKGE-LNSYLIEITADILrQKDEETgkplvdvildkagqkgtgK- 253

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1083527501 216 fsgiigggstgeWTVETAKELEVKVPVIKESLDAR 250
Cdd:PRK09287  254 ------------WTSQSALDLGVPLTLITEAVFAR 276
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 9-250 3.10e-63

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 205.71  E-value: 3.10e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501   9 RSPDKLRD---DRSIGK-LTPCYNLNHLVNNLAPPRIIWLMVEHGKPVDEVIRELiKAGVTKGDIIIDGGNSFYKDSVKR 84
Cdd:TIGR00873  30 RTPSKTDEflaEEAKGKsIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAVIDSL-LPLLEKGDIIIDGGNSHYPDTERR 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501  85 HKFLKEKGINFLDMGTSGGLEGARNGACLMIGGEKNIYEKLVPLFQKLIGTKGGYA---YFGPAGAGHFVKMVHNGVEYG 161
Cdd:TIGR00873 109 YKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKVDGEPcctWVGPGGAGHYVKMVHNGIEYG 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501 162 MLQAIGEGFELLAKGpydLNF-----HLISKNWNSGsVVRGWLMELLERALQKD-----PKLKSFSGIIGGGSTGEWTVE 231
Cdd:TIGR00873 189 DMQLICEAYDILKRG---LGLsneeiAEIFTEWNNG-ELDSYLIEITADILAKKdedgnPLVDKILDTAGQKGTGKWTAI 264

                         250
                  ....*....|....*....
gi 1083527501 232 TAKELEVKVPVIKESLDAR 250
Cdd:TIGR00873 265 NALDLGVPLTLITESVFAR 283
PTZ00142 PTZ00142
6-phosphogluconate dehydrogenase; Provisional
 26-250 1.07e-53

6-phosphogluconate dehydrogenase; Provisional


Pssm-ID: 240287 [Multi-domain]  Cd Length: 470  Bit Score: 180.75  E-value: 1.07e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501  26 CYNLNHLVNNLAPPRIIWLMVEHGKPVDEVIRELIKAgVTKGDIIIDGGNSFYKDSVKRHKFLKEKGINFLDMGTSGGLE 105
Cdd:PTZ00142   54 YHTLEELVNSLKKPRKVILLIKAGEAVDETIDNLLPL-LEKGDIIIDGGNEWYLNTERRIKRCEEKGILYLGMGVSGGEE 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501 106 GARNGACLMIGGEKNIYEKLVPLFQKL---IGTKGGYAYFGPAGAGHFVKMVHNGVEYGMLQAIGEGFELLaKGPYDLNF 182
Cdd:PTZ00142  133 GARYGPSLMPGGNKEAYDHVKDILEKCsakVGDSPCVTYVGPGSSGHYVKMVHNGIEYGDMQLISESYKLM-KHILGMSN 211

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1083527501 183 HLISK---NWNSGsVVRGWLMELLERALQKDPK------LKSFSGIIGGGSTGEWTVETAKELEVKVPVIKESLDAR 250
Cdd:PTZ00142  212 EELSEvfnKWNEG-ILNSYLIEITAKILAKKDDlgeehlVDKILDIAGSKGTGKWTVQEALERGIPVPTMAASVDAR 287
PLN02350 PLN02350
phosphogluconate dehydrogenase (decarboxylating)
 33-250 2.55e-47

phosphogluconate dehydrogenase (decarboxylating)


Pssm-ID: 215200 [Multi-domain]  Cd Length: 493  Bit Score: 164.50  E-value: 2.55e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501  33 VNNLAPPRIIWLMVEHGKPVDEVIrELIKAGVTKGDIIIDGGNSFYKDSVKRHKFLKEKGINFLDMGTSGGLEGARNGAC 112
Cdd:PLN02350   67 VLSIQKPRSVIILVKAGAPVDQTI-KALSEYMEPGDCIIDGGNEWYENTERRIKEAAEKGLLYLGMGVSGGEEGARNGPS 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501 113 LMIGGEKNIYEKLVPLFQKLIG-TKGG--YAYFGPAGAGHFVKMVHNGVEYGMLQAIGEGFELLAK--GPYDLNFHLISK 187
Cdd:PLN02350  146 LMPGGSFEAYKNIEDILEKVAAqVDDGpcVTYIGPGGAGNFVKMVHNGIEYGDMQLISEAYDVLKSvgGLSNEELAEVFA 225

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1083527501 188 NWNSGSvVRGWLMELLERALQ-KDPKLKSFSG-----IIGGGSTGEWTVETAKELEVKVPVIKESLDAR 250
Cdd:PLN02350  226 EWNKGE-LESFLIEITADIFSvKDDKGDGYLVdkildKTGMKGTGKWTVQQAAELSVAAPTIAASLDAR 293
NAD_binding_2 pfam03446
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ...
 9-132 8.37e-35

NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.


Pssm-ID: 427298 [Multi-domain]  Cd Length: 159  Bit Score: 122.96  E-value: 8.37e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501   9 RSPDKLRDDRSIGkLTPCYNLNHLVNNLappRIIWLMVEHGKPVDEVI-RELIKAGVTKGDIIIDGGNSFYKDSVKRHKF 87
Cdd:pfam03446  30 RTPEKVEELVAAG-AIAAASPAEFVAGL---DVVITMVPAGAAVDAVIfGEGLLPGLKPGDIIIDGSTSSPEDARRRAKE 105

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1083527501  88 LKEKGINFLDMGTSGGLEGARNGAC-LMIGGEKNIYEKLVPLFQKL 132
Cdd:pfam03446 106 LKEKGLHFLDAPVSGGEAGAENGTLsIMVGGDEEAFERVKPILEAM 151
MmsB COG2084
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ...
 41-175 1.57e-17

3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism];


Pssm-ID: 441687 [Multi-domain]  Cd Length: 285  Bit Score: 80.16  E-value: 1.57e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501  41 IIWLMVEHGKPVDEVIREL--IKAGVTKGDIIIDGGNSFYKDSVKRHKFLKEKGINFLDMGTSGGLEGARNGAC-LMIGG 117
Cdd:COG2084    60 VVITMLPDDAAVEEVLLGEdgLLAALRPGAVVVDMSTISPETARELAAAAAARGVRYLDAPVSGGPAGAEAGTLtIMVGG 139

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1083527501 118 EKNIYEKLVPLFQKLiGTKggYAYFGPAGAGHFVKMVHNGVEYGMLQAIGEGFELLAK 175
Cdd:COG2084   140 DEAAFERARPVLEAM-GKR--IVHVGDAGAGQAAKLANNLLLAGTMAALAEALALAEK 194
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 148-250 1.02e-15

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 75.18  E-value: 1.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501 148 GHFVKMVHNGVEYGMLQAIGEGFELLAKGpydLNF-----HLISKNWNSGsVVRGWLMELLERAL-QKDPKLKSFsgiig 221
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRG---LGLsndeiADVFEEWNKG-ELDSYLIEITADILrKKDPEDGKP----- 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1083527501 222 ggsTGE-------------WTVETAKELEVKVPVIKESLDAR 250
Cdd:pfam00393  72 ---LVDkildkagqkgtgkWTVQEALDLGVPAPTIAEAVFAR 110
garR PRK11559
tartronate semialdehyde reductase; Provisional
 41-175 3.79e-08

tartronate semialdehyde reductase; Provisional


Pssm-ID: 183197 [Multi-domain]  Cd Length: 296  Bit Score: 53.13  E-value: 3.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501  41 IIWLMVEHGKPVDEVI--RELIKAGVTKGDIIIDGGNSFYKDSVKRHKFLKEKGINFLDMGTSGGLEGARNGA-CLMIGG 117
Cdd:PRK11559   61 VIITMLPNSPHVKEVAlgENGIIEGAKPGTVVIDMSSIAPLASREIAAALKAKGIEMLDAPVSGGEPKAIDGTlSVMVGG 140

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1083527501 118 EKNIYEKLVPLFQKLIGTkggYAYFGPAGAGHFVKMVHNGVEYGMLQAIGEGFELLAK 175
Cdd:PRK11559  141 DKAIFDKYYDLMKAMAGS---VVHTGDIGAGNVTKLANQVIVALNIAAMSEALVLATK 195
PRK15059 PRK15059
2-hydroxy-3-oxopropionate reductase;
41-179 1.61e-07

2-hydroxy-3-oxopropionate reductase;


Pssm-ID: 185019 [Multi-domain]  Cd Length: 292  Bit Score: 51.56  E-value: 1.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527501  41 IIWLMVEHGKPVDEVI--RELIKAGVTKGDIIIDGGNSFYKDSVKRHKFLKEKGINFLDMGTSGGLEGARNGA-CLMIGG 117
Cdd:PRK15059   58 IIFIMVPDTPQVEEVLfgENGCTKASLKGKTIVDMSSISPIETKRFARQVNELGGDYLDAPVSGGEIGAREGTlSIMVGG 137

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1083527501 118 EKNIYEKLVPLFQkLIGTKggYAYFGPAGAGHFVKMVHNGVEYGMLQAIGEGFELLAKGPYD 179
Cdd:PRK15059  138 DEAVFERVKPLFE-LLGKN--ITLVGGNGDGQTCKVANQIIVALNIEAVSEALLFASKAGAD 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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