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Conserved domains on  [gi|1083527485|gb|OGG27477|]
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hypothetical protein A2960_04230 [Candidatus Gottesmanbacteria bacterium RIFCSPLOWO2_01_FULL_39_12b]

Protein Classification

glycosyltransferase family 4 protein( domain architecture ID 10133505)

glycosyltransferase family 4 (GT4) protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

CAZY:  GT4
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
SCOP:  3001586

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
2-343 4.71e-129

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


:

Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 372.39  E-value: 4.71e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485   2 KIAILAPPYLPIPPNGYGGVERIVYYLTEGLVKKGHDVTLFAPGDSKVSSQVFSTFPFSLG-NSGEIKNKPY---LPLLQ 77
Cdd:cd03802     1 RIAQVSPPRGPVPPGKYGGTELVVSALTEGLVRRGHEVTLFAPGDSHTSAPLVAVIPRALRlDPIPQESKLAellEALEV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  78 YIDcfkkASGFDIIHNHAEHMAMFFADLVTTPVVHTLHSTLvegetLEEKRKVLLRFKNHNFVSISDNQREGLKELNFAG 157
Cdd:cd03802    81 QLR----ASDFDVIHNHSYDWLPPFAPLIGTPFVTTLHGPS-----IPPSLAIYAAEPPVNYVSISDAQRAATPPIDYLT 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 158 TVYNGIDIHKYSYIEKPrGDYLLWVGRITRKKGPLSAIEVAKKVSIPLVIAAAIDPVEKLFFEEEVKPqidGKTVSFVGE 237
Cdd:cd03802   152 VVHNGLDPADYRFQPDP-EDYLAFLGRIAPEKGLEDAIRVARRAGLPLKIAGKVRDEDYFYYLQEPLP---GPRIEFIGE 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 238 LHGESLNKLYGNALCTLFPITWHEPFGLVMVESMACGTPVIAYRIGSTSEVIEDGVTGFIVDDLYQMIEAVKNIDKIKRK 317
Cdd:cd03802   228 VGHDEKQELLGGARALLFPINWDEPFGLVMIEAMACGTPVIAYRRGGLPEVIQHGETGFLVDSVEEMAEAIANIDRIDRA 307
                         330       340
                  ....*....|....*....|....*.
gi 1083527485 318 KCRERVVEKFTIEKMVNHYEDIYSKL 343
Cdd:cd03802   308 ACRRYAEDRFSAARMADRYEALYRKV 333
 
Name Accession Description Interval E-value
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
2-343 4.71e-129

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 372.39  E-value: 4.71e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485   2 KIAILAPPYLPIPPNGYGGVERIVYYLTEGLVKKGHDVTLFAPGDSKVSSQVFSTFPFSLG-NSGEIKNKPY---LPLLQ 77
Cdd:cd03802     1 RIAQVSPPRGPVPPGKYGGTELVVSALTEGLVRRGHEVTLFAPGDSHTSAPLVAVIPRALRlDPIPQESKLAellEALEV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  78 YIDcfkkASGFDIIHNHAEHMAMFFADLVTTPVVHTLHSTLvegetLEEKRKVLLRFKNHNFVSISDNQREGLKELNFAG 157
Cdd:cd03802    81 QLR----ASDFDVIHNHSYDWLPPFAPLIGTPFVTTLHGPS-----IPPSLAIYAAEPPVNYVSISDAQRAATPPIDYLT 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 158 TVYNGIDIHKYSYIEKPrGDYLLWVGRITRKKGPLSAIEVAKKVSIPLVIAAAIDPVEKLFFEEEVKPqidGKTVSFVGE 237
Cdd:cd03802   152 VVHNGLDPADYRFQPDP-EDYLAFLGRIAPEKGLEDAIRVARRAGLPLKIAGKVRDEDYFYYLQEPLP---GPRIEFIGE 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 238 LHGESLNKLYGNALCTLFPITWHEPFGLVMVESMACGTPVIAYRIGSTSEVIEDGVTGFIVDDLYQMIEAVKNIDKIKRK 317
Cdd:cd03802   228 VGHDEKQELLGGARALLFPINWDEPFGLVMIEAMACGTPVIAYRRGGLPEVIQHGETGFLVDSVEEMAEAIANIDRIDRA 307
                         330       340
                  ....*....|....*....|....*.
gi 1083527485 318 KCRERVVEKFTIEKMVNHYEDIYSKL 343
Cdd:cd03802   308 ACRRYAEDRFSAARMADRYEALYRKV 333
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
246-345 6.41e-25

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 97.37  E-value: 6.41e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 246 LYGNALCTLFPiTWHEPFGLVMVESMACGTPVIAYRIGSTSEVIEDGVTGFIVD-----DLYQ-MIEAVKNIDKIKR--K 317
Cdd:COG0438    17 LLAAADVFVLP-SRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPpgdpeALAEaILRLLEDPELRRRlgE 95
                          90       100
                  ....*....|....*....|....*...
gi 1083527485 318 KCRERVVEKFTIEKMVNHYEDIYSKLIK 345
Cdd:COG0438    96 AARERAEERFSWEAIAERLLALYEELLA 123
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
178-322 6.33e-22

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 90.41  E-value: 6.33e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 178 YLLWVGRITRKKGPLSAIEVAKKV-----SIPLVIAAaiDPVEKLFFEEEVKPQIDGKTVSFVGELHGESLNKLYGNALC 252
Cdd:pfam00534   4 IILFVGRLEPEKGLDLLIKAFALLkeknpNLKLVIAG--DGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADV 81
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1083527485 253 TLFPITWhEPFGLVMVESMACGTPVIAYRIGSTSEVIEDGVTGFIVDDlYQMIEAVKNIDKI-----KRKKCRER 322
Cdd:pfam00534  82 FVLPSRY-EGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKP-NNAEALAEAIDKLledeeLRERLGEN 154
stp2 TIGR03088
sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match ...
261-344 2.23e-12

sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match to the pfam00534 Glycosyl transferases group 1 domain. Nearly all are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria. In particular, these transferases are found proximal to a particular variant of exosortase, EpsH1, which appears to travel with a conserved group of genes summarized by Genome Property GenProp0652. The nature of the sugar transferase reaction catalyzed by members of this clade is unknown and may conceivably be variable with respect to substrate by species, but we hypothesize a conserved substrate.


Pssm-ID: 132132 [Multi-domain]  Cd Length: 374  Bit Score: 67.44  E-value: 2.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 261 EPFGLVMVESMACGTPVIAYRIGSTSEVIEDGVTGFIV--DDLYQMIEA----VKNIDKIKRKKC--RERVVEKFTIEKM 332
Cdd:TIGR03088 283 EGISNTILEAMASGLPVIATAVGGNPELVQHGVTGALVppGDAVALARAlqpyVSDPAARRAHGAagRARAEQQFSINAM 362
                          90
                  ....*....|..
gi 1083527485 333 VNHYEDIYSKLI 344
Cdd:TIGR03088 363 VAAYAGLYDQLL 374
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
219-327 1.24e-08

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 56.26  E-value: 1.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 219 FEEEVKPQIDGKTVSFVGELHGESLNKLYGNALCTLFPiTWHEPFGLVMVESMACGTPVIAYRIGSTSEVI---EDGVTG 295
Cdd:PLN02871  301 YREELEKMFAGTPTVFTGMLQGDELSQAYASGDVFVMP-SESETLGFVVLEAMASGVPVVAARAGGIPDIIppdQEGKTG 379
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1083527485 296 FI-----VDDLYQMIEAVKNIDKIK---RKKCRERvVEKF 327
Cdd:PLN02871  380 FLytpgdVDDCVEKLETLLADPELRermGAAAREE-VEKW 418
 
Name Accession Description Interval E-value
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
2-343 4.71e-129

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 372.39  E-value: 4.71e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485   2 KIAILAPPYLPIPPNGYGGVERIVYYLTEGLVKKGHDVTLFAPGDSKVSSQVFSTFPFSLG-NSGEIKNKPY---LPLLQ 77
Cdd:cd03802     1 RIAQVSPPRGPVPPGKYGGTELVVSALTEGLVRRGHEVTLFAPGDSHTSAPLVAVIPRALRlDPIPQESKLAellEALEV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  78 YIDcfkkASGFDIIHNHAEHMAMFFADLVTTPVVHTLHSTLvegetLEEKRKVLLRFKNHNFVSISDNQREGLKELNFAG 157
Cdd:cd03802    81 QLR----ASDFDVIHNHSYDWLPPFAPLIGTPFVTTLHGPS-----IPPSLAIYAAEPPVNYVSISDAQRAATPPIDYLT 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 158 TVYNGIDIHKYSYIEKPrGDYLLWVGRITRKKGPLSAIEVAKKVSIPLVIAAAIDPVEKLFFEEEVKPqidGKTVSFVGE 237
Cdd:cd03802   152 VVHNGLDPADYRFQPDP-EDYLAFLGRIAPEKGLEDAIRVARRAGLPLKIAGKVRDEDYFYYLQEPLP---GPRIEFIGE 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 238 LHGESLNKLYGNALCTLFPITWHEPFGLVMVESMACGTPVIAYRIGSTSEVIEDGVTGFIVDDLYQMIEAVKNIDKIKRK 317
Cdd:cd03802   228 VGHDEKQELLGGARALLFPINWDEPFGLVMIEAMACGTPVIAYRRGGLPEVIQHGETGFLVDSVEEMAEAIANIDRIDRA 307
                         330       340
                  ....*....|....*....|....*.
gi 1083527485 318 KCRERVVEKFTIEKMVNHYEDIYSKL 343
Cdd:cd03802   308 ACRRYAEDRFSAARMADRYEALYRKV 333
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
2-340 1.54e-57

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 190.44  E-value: 1.54e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485   2 KIAILAPPYLPippnGYGGVERIVYYLTEGLVKKGHDVTLFAPGDSKVSSQVFSTFPFSLGNSGEIKNKPYLPLLQYIDC 81
Cdd:cd03801     1 KILLLSPELPP----PVGGAERHVRELARALAARGHDVTVLTPADPGEPPEELEDGVIVPLLPSLAALLRARRLLRELRP 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  82 FKKASGFDIIHNHAEHMAMFFADL---VTTPVVHTLHSTLVEGETLEE--KRKVL-----LRFKNHNFVSISDNQREGLK 151
Cdd:cd03801    77 LLRLRKFDVVHAHGLLAALLAALLallLGAPLVVTLHGAEPGRLLLLLaaERRLLaraeaLLRRADAVIAVSEALRDELR 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 152 ELNFAG-----TVYNGIDIHKYS------YIEKPRGDYLLWVGRITRKKGPLSAIEVAKKV-----SIPLVIAAAIDPVE 215
Cdd:cd03801   157 ALGGIPpekivVIPNGVDLERFSpplrrkLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKLlrrgpDVRLVIVGGDGPLR 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 216 KLFFEEEVKpqiDGKTVSFVGELHGESLNKLYGNALCTLFPiTWHEPFGLVMVESMACGTPVIAYRIGSTSEVIEDGVTG 295
Cdd:cd03801   237 AELEELELG---LGDRVRFLGFVPDEELPALYAAADVFVLP-SRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVEDGEGG 312
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1083527485 296 FIVD-----DLYQ-MIEAVKNIDKIKR--KKCRERVVEKFTIEKMVNHYEDIY 340
Cdd:cd03801   313 LVVPpddveALADaLLRLLADPELRARlgRAARERVAERFSWERVAERLLDLY 365
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
2-322 3.80e-30

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 117.84  E-value: 3.80e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485   2 KIAILappylpIPPNGYGGVERIVYYLTEGLVKKGHDVTLFAPGDS-----KVSSQVFST-FPFSLGNSGEIKNKPYLPL 75
Cdd:cd03811     1 KILFV------IPSLSGGGAERVLLNLANALDKRGYDVTLVLLRDEgdldkQLNGDVKLIrLLIRVLKLIKLGLLKAILK 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  76 LQYIdcFKKASgFDIIHNHAEHMAMFFA--DLVTTPVVHTLHSTLVEGETLEEK--RKVLLRFKNHNFVSISDNQREGLK 151
Cdd:cd03811    75 LKRI--LKRAK-PDVVISFLGFATYIVAklAAARSKVIAWIHSSLSKLYYLKKKllLKLKLYKKADKIVCVSKGIKEDLI 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 152 ELNFAG-----TVYNGIDIH-------KYSYIEKPRGDYLLWVGRITRKKGPLSAIEVAKKV-----SIPLVIAAAIDPV 214
Cdd:cd03811   152 RLGPSPpekieVIYNPIDIDriralakEPILNEPEDGPVILAVGRLDPQKGHDLLIEAFAKLrkkypDVKLVILGDGPLR 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 215 EKLffEEEVKPQIDGKTVSFVGELhgESLNKLYGNALCTLFPITwHEPFGLVMVESMACGTPVIAYRIGSTSEVIEDGVT 294
Cdd:cd03811   232 EEL--EKLAKELGLAERVIFLGFQ--SNPYPYLKKADLFVLSSR-YEGFPNVLLEAMALGTPVVSTDCPGPREILDDGEN 306
                         330       340       350
                  ....*....|....*....|....*....|...
gi 1083527485 295 GFIVDD-----LYQMIEAVKNIDKIKRKKCRER 322
Cdd:cd03811   307 GLLVPDgdaaaLAGILAALLQKKLDAALRERLA 339
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
2-337 1.16e-29

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 116.54  E-value: 1.16e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485   2 KIAILAppylpippNGYGGVERIVYYLTEGLVKKGHDVTLFAPGDSKVSSQV----FSTFPFSLGNSGEIKNKPYLPLLQ 77
Cdd:cd03808     1 KILFIV--------NVDGGFQSFRLPLIKALVKKGYEVHVIAPDGDKLSDELkelgVKVIDIPILRRGINPLKDLKALFK 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  78 YIDCFKKaSGFDIIHNH---AEHMAMFFADLV-TTPVVHTLHST-LVEGETLEEKR------KVLLRFKNHNFVsISDNQ 146
Cdd:cd03808    73 LYKLLKK-EKPDIVHCHtpkPGILGRLAARLAgVPKVIYTVHGLgFVFTEGKLLRLlyllleKLALLFTDKVIF-VNEDD 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 147 REGLKELNFAG----TVYNGI----DIHKYSYIEKPRGDY-LLWVGRITRKKGPLSAIEVAKKVSIP-----LVIAAAID 212
Cdd:cd03808   151 RDLAIKKGIIKkkktVLIPGSgvdlDRFQYSPESLPSEKVvFLFVARLLKDKGIDELIEAAKILKKKgpnvrFLLVGDGE 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 213 PveKLFFEEEVKPQIDGKTVSFVGelHGESLNKLYGNALCTLFPiTWHEPFGLVMVESMACGTPVIAYRIGSTSEVIEDG 292
Cdd:cd03808   231 L--ENPSEILIEKLGLEGRIEFLG--FRSDVPELLAESDVFVLP-SYREGLPRSLLEAMAAGRPVITTDVPGCRELVIDG 305
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1083527485 293 VTGFIV-----DDLYQMIEA-VKNIDKIKR--KKCRERVVEKFTIEKMVNHYE 337
Cdd:cd03808   306 VNGFLVppgdvEALADAIEKlIEDPELRKEmgEAARKRVEEKFDEEKVVNKLL 358
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
14-333 5.70e-27

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 108.90  E-value: 5.70e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  14 PPNgYGGVERIVYYLTEGLVKKGHDVTLFAPGDSKVSS-QVFSTFPFSLGNS-GEIKNKPYLPLlqYIDCFKK-ASGFDI 90
Cdd:cd03795    10 YPD-IGGIEQVIYDLAEGLKKKGIEVDVLCFSKEKETPeKEENGIRIHRVKSfLNVASTPFSPS--YIKRFKKlAKEYDI 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  91 IHNHAEH----MAMFFADlVTTPVVHTLHSTLVegetleeKRKVLLRFKN---HNF-------VSISDNQREGLKEL--- 153
Cdd:cd03795    87 IHYHFPNpladLLLFFSG-AKKPVVVHWHSDIV-------KQKKLLKLYKplmTRFlrradriIATSPNYVETSPTLref 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 154 -NFAGTVYNGIDIHKYS---------YIEKPRGDYLLWVGRITRKKGPLSAIEVAKKVSIPLVIAAAIDPVEKLffeeev 223
Cdd:cd03795   159 kNKVRVIPLGIDKNVYNiprvdfeniKREKKGKKIFLFIGRLVYYKGLDYLIEAAQYLNYPIVIGGEGPLKPDL------ 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 224 KPQID---GKTVSFVGELHGESLNKLYGNALCTLFP-ITWHEPFGLVMVESMACGTPVIAYRIG-STSEVIEDGVTGFIV 298
Cdd:cd03795   233 EAQIElnlLDNVKFLGRVDDEEKVIYLHLCDVFVFPsVLRSEAFGIVLLEAMMCGKPVISTNIGtGVPYVNNNGETGLVV 312
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1083527485 299 -----DDLYQMIEAVKNIDKIKR---KKCRERVVEKFTIEKMV 333
Cdd:cd03795   313 ppkdpDALAEAIDKLLSDEELREsygENAKKRFEELFTAEKMK 355
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
2-343 2.35e-25

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 105.05  E-value: 2.35e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485   2 KIAILAPPYLPIPpngyGGVERIVYYLTEGLVKKGHDVTLFAPGDSKVSSQVFSTFPFSLGNSGEIKNKPYLPLLQ---Y 78
Cdd:cd03817     1 KIAIFTDTYLPQV----NGVATSVRNLARALEKRGHEVYVITPSDPGAEDEEEVVRYRSFSIPIRKYHRQHIPFPFkkaV 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  79 IDCFKKAsGFDIIHNHAE----HMAMFFADLVTTPVVHTLHsTLVE--------GETLEEK--RKVLLRFKNHN--FVSI 142
Cdd:cd03817    77 IDRIKEL-GPDIIHTHTPfslgKLGLRIARKLKIPIVHTYH-TMYEdylhyipkGKLLVKAvvRKLVRRFYNHTdaVIAP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 143 SDNQREGLKELNFAGTVY---NGIDIHKY--SYIEKPRGDY--------LLWVGRITRKKGPLSAIEVAKKVS----IPL 205
Cdd:cd03817   155 SEKIKDTLREYGVKGPIEvipNGIDLDKFekPLNTEERRKLglppdepiLLYVGRLAKEKNIDFLLRAFAELKkepnIKL 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 206 VIA---AAIDPVEKLFFEEEVkpqidGKTVSFVGELHGESLNKLYgnALCTLFPITWH-EPFGLVMVESMACGTPVIAYR 281
Cdd:cd03817   235 VIVgdgPEREELKELARELGL-----ADKVIFTGFVPREELPEYY--KAADLFVFASTtETQGLVYLEAMAAGLPVVAAK 307
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 282 IGSTSEVIEDGVTGFIVDDlyQMIEAVKNIDKIKRKKCRERV--------VEKFTIEKMVnhyEDIYSKL 343
Cdd:cd03817   308 DPAASELVEDGENGFLFEP--NDETLAEKLLHLRENLELLRKlsknaeisAREFAFAKSV---EKLYEEV 372
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
17-338 2.41e-25

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 104.75  E-value: 2.41e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  17 GYGGVERIVYYLTEGLVKKGHDVTLFAPGDSKVSSQVFS--TFPFSLGNSGEIKNKPYLPLLQYIDCFKKASGFDIIHNH 94
Cdd:cd03809    12 RLTGIGRYTRELLKALAKNDPDESVLAVPPLPGELLRLLreYPELSLGVIKIKLWRELALLRWLQILLPKKDKPDLLHSP 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  95 AEHMAMFFADlvtTPVVHTLH--STLVEGETLEEKRKVLLRF-------KNHNFVSISDNQREGLKEL------NFAgTV 159
Cdd:cd03809    92 HNTAPLLLKG---CPQVVTIHdlIPLRYPEFFPKRFRLYYRLllpislrRADAIITVSEATRDDIIKFygvppeKIV-VI 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 160 YNGIDIHKYSYIEKPR--------GDYLLWVGRITRKKGPLSAIEVAKKVS-----IPLVIAAAIDP-VEKLFfeEEVKP 225
Cdd:cd03809   168 PLGVDPSFFPPESAAVliakyllpEPYFLYVGTLEPRKNHERLLKAFALLKkqggdLKLVIVGGKGWeDEELL--DLVKK 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 226 QIDGKTVSFVGELHGESLNKLYGNALCTLFPiTWHEPFGLVMVESMACGTPVIAYRIGSTSEVIEDGVTGF-------IV 298
Cdd:cd03809   246 LGLGGRVRFLGYVSDEDLPALYRGARAFVFP-SLYEGFGLPVLEAMACGTPVIASNISVLPEVAGDAALYFdpldpesIA 324
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1083527485 299 DDLYQMIEAvKNIDKIKRKKCRERvVEKFTIEKMVNHYED 338
Cdd:cd03809   325 DAILRLLED-PSLREELIRKGLER-AKKFSWEKTAEKTLE 362
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
2-338 2.76e-25

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 104.33  E-value: 2.76e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485   2 KIAILAPPYlpiPPNGYGGVERIVYYLTEGLVKKGHDVTLFAP--GDSKVSSQVFSTFPFSLGNSGEIKNKPYLP----- 74
Cdd:cd03823     1 KILLVNSLY---PPQRVGGAEISVHDLAEALVAEGHEVAVLTAgvGPPGQATVARSVVRYRRAPDETLPLALKRRgyelf 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  75 ----------LLQYIDCFKkasgFDIIHNHaeHMAMFFADLVTT------PVVHTLHSTLvegetLEEKRKVLLRfKNHN 138
Cdd:cd03823    78 etynpglrrlLARLLEDFR----PDVVHTH--NLSGLGASLLDAardlgiPVVHTLHDYW-----LLCPRQFLFK-KGGD 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 139 -FVSIS----DN-QREGLKELNFaGTVYNGIDIHKY------SYIEKPRgdyLLWVGRITRKKGPLSAIEVAKKV---SI 203
Cdd:cd03823   146 aVLAPSrftaNLhEANGLFSARI-SVIPNAVEPDLAppprrrPGTERLR---FGYIGRLTEEKGIDLLVEAFKRLpreDI 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 204 PLVIAaaidpvEKLFFEEEVKPQIDGKtVSFVGELHGESLNKLYGNALCTLFPITWHEPFGLVMVESMACGTPVIAYRIG 283
Cdd:cd03823   222 ELVIA------GHGPLSDERQIEGGRR-IAFLGRVPTDDIKDFYEKIDVLVVPSIWPEPFGLVVREAIAAGLPVIASDLG 294
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1083527485 284 STSEVIEDGVTGFI-----VDDLY---QMIEAVKNIDKIKRKKCRERVVEKFTIEKMVNHYED 338
Cdd:cd03823   295 GIAELIQPGVNGLLfapgdAEDLAaamRRLLTDPALLERLRAGAEPPRSTESQAEEYLKLYRD 357
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
246-345 6.41e-25

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 97.37  E-value: 6.41e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 246 LYGNALCTLFPiTWHEPFGLVMVESMACGTPVIAYRIGSTSEVIEDGVTGFIVD-----DLYQ-MIEAVKNIDKIKR--K 317
Cdd:COG0438    17 LLAAADVFVLP-SRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPpgdpeALAEaILRLLEDPELRRRlgE 95
                          90       100
                  ....*....|....*....|....*...
gi 1083527485 318 KCRERVVEKFTIEKMVNHYEDIYSKLIK 345
Cdd:COG0438    96 AARERAEERFSWEAIAERLLALYEELLA 123
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
3-343 7.89e-25

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 103.61  E-value: 7.89e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485   3 IAILAPPYlpiPPNGYGGVERIVYYLTEGLVKKGHDVTLFAPGD--SKVSSQVFSTF---PFSLGNSGEIKNKPYLPLLQ 77
Cdd:cd03798     1 VLILTNIY---PNANSPGRGIFVRRQVRALSRRGVDVEVLAPAPwgPAAARLLRKLLgeaVPPRDGRRLLPLKPRLRLLA 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  78 -----YIDCFKKASG---FDIIHNHAEHMAMFFADLV----TTPVVHTLHSTLV-EGETLEEKRKVLLRFKNHN----FV 140
Cdd:cd03798    78 plrapSLAKLLKRRRrgpPDLIHAHFAYPAGFAAALLarlyGVPYVVTEHGSDInVFPPRSLLRKLLRWALRRAarviAV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 141 SISDnqREGLKELNFAGT----VYNGIDIHKYS-----YIEKPRGDYLLWVGRITRKKGPLSAIEVAKK-----VSIPLV 206
Cdd:cd03798   158 SKAL--AEELVALGVPRDrvdvIPNGVDPARFQpedrgLGLPLDAFVILFVGRLIPRKGIDLLLEAFARlakarPDVVLL 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 207 IA---AAIDPVEKLFFEEEVKPQidgktVSFVGELHGESLNKLYgnALCTLFPI-TWHEPFGLVMVESMACGTPVIAYRI 282
Cdd:cd03798   236 IVgdgPLREALRALAEDLGLGDR-----VTFTGRLPHEQVPAYY--RACDVFVLpSRHEGFGLVLLEAMACGLPVVATDV 308
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1083527485 283 GSTSEVIEDGVTGFIVDD------LYQMIEAV-KNIDKIKRKKCRERVVEKFTIEKMVNHYEDIYSKL 343
Cdd:cd03798   309 GGIPEVVGDPETGLLVPPgdadalAAALRRALaEPYLRELGEAARARVAERFSWVKAADRIAAAYRDV 376
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
2-301 2.33e-24

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 101.99  E-value: 2.33e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485   2 KIAILAPPYLPIppngYGGVERIVYYLTEGLVKKGHDVTLFAPG-----DSKVSSQV-FSTFPFSLGNSGEIKNKPYLPL 75
Cdd:cd03814     1 RIALVTDTYHPQ----VNGVVRTLERLVDHLRRRGHEVRVVAPGpfdeaESAEGRVVsVPSFPLPFYPEYRLALPLPRRV 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  76 LQYIDCFkkasGFDIIHNHAE----HMAMFFADLVTTPVV---HTLHSTLVE----GETLEEKRKVLLRFKNH---NFVS 141
Cdd:cd03814    77 RRLIKEF----QPDIIHIATPgplgLAALRAARRLGLPVVtsyHTDFPEYLSyytlGPLSWLAWAYLRWFHNPfdtTLVP 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 142 ISDNQREgLKELNF--AGTVYNGIDI-------------HKYSYIEKPRgdyLLWVGRITRKKGplsaIEVAKKVSIPLv 206
Cdd:cd03814   153 SPSIARE-LEGHGFerVRLWPRGVDTelfhpsrrdaalrRRLGPPGRPL---LLYVGRLAPEKN----LEALLDADLPL- 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 207 iaAAIDPVEKLFF--------EEEVKPQidgktVSFVGELHGESLNKLYGNALCTLFPITwHEPFGLVMVESMACGTPVI 278
Cdd:cd03814   224 --AASPPVRLVVVgdgparaeLEARGPD-----VIFTGFLTGEELARAYASADVFVFPSR-TETFGLVVLEAMASGLPVV 295
                         330       340
                  ....*....|....*....|...
gi 1083527485 279 AYRIGSTSEVIEDGVTGFIVDDL 301
Cdd:cd03814   296 AADAGGPRDIVRPGGTGALVEPG 318
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
19-340 7.97e-23

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 97.77  E-value: 7.97e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  19 GGVERIVYYLTEGLVKKGHDVTLFAPGDSKVSSQVFSTFPF---SLGNSGeiknKPYLP-LLQYIDCFKKaSGFDIIHNH 94
Cdd:cd03807    12 GGAETMLLRLLEHMDKSRFEHVVISLTGDGVLGEELLAAGVpvvCLGLSS----GKDPGvLLRLAKLIRK-RNPDVVHTW 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  95 AEHmAMFFADLVT-----TPVVHTLHSTLvegetlEEKRKVLLRFKNHNF--------VSISDNQREGLKELNFA----G 157
Cdd:cd03807    87 MYH-ADLIGGLAAklaggVKVIWSVRSSN------IPQRLTRLVRKLCLLlskfspatVANSSAVAEFHQEQGYAknkiV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 158 TVYNGIDIHKYSY-----------IEKPRGDYLLW-VGRITRKKGPLSAIEVAKKV-----SIPLVIAAaidpveklffE 220
Cdd:cd03807   160 VIYNGIDLFKLSPddasrararrrLGLAEDRRVIGiVGRLHPVKDHSDLLRAAALLvethpDLRLLLVG----------R 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 221 EEVKPQID--------GKTVSFVGELH--GESLNKLYGNALCTLfpitwHEPFGLVMVESMACGTPVIAYRIGSTSEVIE 290
Cdd:cd03807   230 GPERPNLErlllelglEDRVHLLGERSdvPALLPAMDIFVLSSR-----TEGFPNALLEAMACGLPVVATDVGGAAELVD 304
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1083527485 291 DGvTGFIV-----DDLYQMIEAVKNiDKIKRKK----CRERVVEKFTIEKMVNHYEDIY 340
Cdd:cd03807   305 DG-TGFLVpagdpQALADAIRALLE-DPEKRARlgraARERIANEFSIDAMVRRYETLY 361
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
2-338 1.66e-22

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 97.05  E-value: 1.66e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485   2 KIAILAPPYLPIppngYGGVERIVYYLTEGLVKKGHDVTLFAPGDSKVSSQV------------FSTFPFSLGNSGEIKN 69
Cdd:cd03821     1 KILHVTPSISPK----AGGPVKVVLRLAAALAALGHEVTIVSTGDGYESLVVeengryippqdgFASIPLLRQGAGRTDF 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  70 KPYLP--LLQYIDCFkkasgfDIIHNHA--EHMAMFFADLVT---TPVVHTLHSTLV---EGETLEEKRKVLLRFKNHN- 138
Cdd:cd03821    77 SPGLPnwLRRNLREY------DVVHIHGvwTYTSLAACKLARrrgIPYVVSPHGMLDpwaLQQKHWKKRIALHLIERRNl 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 139 ---FVSISDNQREgLKELNFAGT------VYNGIDIHKY----SYIEK----PRGDYLLWVGRITRKKGPLSAIEVAKKV 201
Cdd:cd03821   151 nnaALVHFTSEQE-ADELRRFGLeppiavIPNGVDIPEFdpglRDRRKhnglEDRRIILFLGRIHPKKGLDLLIRAARKL 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 202 S-----IPLVIAAAIDPVEKLFFEEEVKPQIDGKtVSFVGELHGESLNKLYGNALCTLFPiTWHEPFGLVMVESMACGTP 276
Cdd:cd03821   230 AeqgrdWHLVIAGPDDGAYPAFLQLQSSLGLGDR-VTFTGPLYGEAKWALYASADLFVLP-SYSENFGNVVAEALACGLP 307
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1083527485 277 VIAYRIGSTSEVIEDGvTGFIVDDLYQMI-EAVKNI--DKIKRKKCRER------VVEKFTIEKMVNHYED 338
Cdd:cd03821   308 VVITDKCGLSELVEAG-CGVVVDPNVSSLaEALAEAlrDPADRKRLGEMarrarqVEENFSWEAVAGQLGE 377
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
178-322 6.33e-22

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 90.41  E-value: 6.33e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 178 YLLWVGRITRKKGPLSAIEVAKKV-----SIPLVIAAaiDPVEKLFFEEEVKPQIDGKTVSFVGELHGESLNKLYGNALC 252
Cdd:pfam00534   4 IILFVGRLEPEKGLDLLIKAFALLkeknpNLKLVIAG--DGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADV 81
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1083527485 253 TLFPITWhEPFGLVMVESMACGTPVIAYRIGSTSEVIEDGVTGFIVDDlYQMIEAVKNIDKI-----KRKKCRER 322
Cdd:pfam00534  82 FVLPSRY-EGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKP-NNAEALAEAIDKLledeeLRERLGEN 154
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
1-343 2.80e-21

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 93.57  E-value: 2.80e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485   1 MKIAILAPPylpippnGYGGVERIVYYLTEGLVKKGHDVTLFApgdskvssqvfSTFPFSLGN-SGEIK----NKPYLPL 75
Cdd:cd04962     1 MKIGIVCYP-------SYGGSGVVATELGLELAERGHEVHFIS-----------SAIPFRLNLySGNIFfhevEVPNYPL 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  76 LQY-----------IDCFKKAsGFDIIHNH-------AEHMA--MFFADlvtTPVVHTLHSTLVEGETLEEKRKVLLRF- 134
Cdd:cd04962    63 FEYppytlalaskiVEVAKEH-KLDVLHAHyaiphasCAYLAreILGEK---IPIVTTLHGTDITLVGYDPSLQPAVRFs 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 135 --KNHNFVSISDNQREGLKEL----NFAGTVYNGIDIHKYSYIEKPR----------GDYLLWVGRITRKKGPLSAIEV- 197
Cdd:cd04962   139 inKSDRVTAVSSSLRQETYELfdvdKDIEVIHNFIDEDVFKRKPAGAlkrrllappdEKVVIHVSNFRPVKRIDDVVRVf 218
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 198 ---AKKVSIPLVIAAA---IDPVEKLFFEEEVkpqidGKTVSFVGELhgESLNKLYGNALCTLFPiTWHEPFGLVMVESM 271
Cdd:cd04962   219 arvRRKIPAKLLLVGDgpeRVPAEELARELGV-----EDRVLFLGKQ--DDVEELLSIADLFLLP-SEKESFGLAALEAM 290
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 272 ACGTPVIAYRIGSTSEVIEDGVTGFI--VDDLYQMIEAVKNI--DKIKRKK----CRERVVEKFTIEKMVNHYEDIYSKL 343
Cdd:cd04962   291 ACGVPVVSSNAGGIPEVVKHGETGFLsdVGDVDAMAKSALSIleDDELYNRmgraARKRAAERFDPERIVPQYEAYYRRL 370
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
19-333 4.24e-21

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 92.42  E-value: 4.24e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  19 GGVERIVYYLTEGLVKKGHDVTLFAPGDSKV--------SSQVFSTFPFSLGNSgeIKNKPYLpllqyidcfKKASGFDI 90
Cdd:cd03819    11 GGAETYILDLARALAERGHRVLVVTAGGPLLprlrqigiGLPGLKVPLLRALLG--NVRLARL---------IRRERIDL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  91 IHNHAEHMAMFFAD---LVTTPVVHTLH-STLVEGETLEekRKVLLRFKNHNFVSISDNQREGLKELNFAG-----TVYN 161
Cdd:cd03819    80 IHAHSRAPAWLGWLasrLTGVPLVTTVHgSYLATYHPKD--FALAVRARGDRVIAVSELVRDHLIEALGVDperirVIPN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 162 GIDIHKYS---------YIEKPRGDY-LLWVGRITRKKGPLSAIEVA----KKVSIPLVIAAaiDPVEKLFFEEEV-KPQ 226
Cdd:cd03819   158 GVDTDRFPpeaeaeeraQLGLPEGKPvVGYVGRLSPEKGWLLLVDAAaelkDEPDFRLLVAG--DGPERDEIRRLVeRLG 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 227 IDGKtVSFVGelHGESLNKLYGNALCTLFPiTWHEPFGLVMVESMACGTPVIAYRIGSTSEVIEDGVTGFIVD--DLYQM 304
Cdd:cd03819   236 LRDR-VTFTG--FREDVPAALAASDVVVLP-SLHEEFGRVALEAMACGTPVVATDVGGAREIVVHGRTGLLVPpgDAEAL 311
                         330       340
                  ....*....|....*....|....*....
gi 1083527485 305 IEAVknIDKIKRKKCRERVVEKFTIEKMV 333
Cdd:cd03819   312 ADAI--RAAKLLPEAREKLQAAAALTEAV 338
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
3-298 1.97e-19

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 85.92  E-value: 1.97e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485   3 IAILAPPYLPippnGYGGVERIVYYLTEGLVKKGHDVTLFAPgdskvssqvfstfpfslgnsgeiknkpYLPLLQYIDCF 82
Cdd:cd01635     1 ILLVTGEYPP----LRGGLELHVRALARALAALGHEVTVLAL---------------------------LLLALRRILKK 49
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  83 KKASGFDIIHNHAEHMAMFFADLVT----TPVVHTLHSTLVEGETLEEKRKVLLRFKNHNFVsisdnqreglkelnfagt 158
Cdd:cd01635    50 LLELKPDVVHAHSPHAAALAALLAArllgIPIVVTVHGPDSLESTRSELLALARLLVSLPLA------------------ 111
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 159 vyngidihkysyiekprgdYLLWVGRITRKKGPLSAIEVAKKV-----SIPLVIAAAIDPVEKLFFEEEVKpqIDGKTVS 233
Cdd:cd01635   112 -------------------DKVSVGRLVPEKGIDLLLEALALLkarlpDLVLVLVGGGGEREEEEALAAAL--GLLERVV 170
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1083527485 234 FVGELHGESLNKLYGNAL-CTLFPiTWHEPFGLVMVESMACGTPVIAYRIGSTSEVIEDGVTGFIV 298
Cdd:cd01635   171 IIGGLVDDEVLELLLAAAdVFVLP-SRSEGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGENGLLV 235
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
71-338 1.03e-17

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 83.44  E-value: 1.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  71 PYLP-----LLQYIdcfKKASG-FDIIHNH---AEHMAMFFADLVTTPVVHTLHStlvegetLE-EKRKVLL-------- 132
Cdd:cd03800    82 PYLEefadgLLRFI---AREGGrYDLIHSHywdSGLVGALLARRLGVPLVHTFHS-------LGrVKYRHLGaqdtyhps 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 133 -RFK-------NHNFV-SISDNQREGLKEL--NFAG---TVYNGIDIHKYSYIEKPRGDY-----------LLWVGRITR 187
Cdd:cd03800   152 lRITaeeqileAADRViASTPQEADELISLygADPSrinVVPPGVDLERFFPVDRAEARRarlllppdkpvVLALGRLDP 231
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 188 KKGPLSAIEVAKKvsIP-------LVIAA-------AIDPVEKLFFEEEVKpqIDGKtVSFVGELHGESLNKLYgnALCT 253
Cdd:cd03800   232 RKGIDTLVRAFAQ--LPelrelanLVLVGgpsddplSMDREELAELAEELG--LIDR-VRFPGRVSRDDLPELY--RAAD 304
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 254 LFPIT-WHEPFGLVMVESMACGTPVIAYRIGSTSEVIEDGVTGFIVD--DLYQMIEAVKNI--DKIKRKKC----RERVV 324
Cdd:cd03800   305 VFVVPsLYEPFGLTAIEAMACGTPVVATAVGGLQDIVRDGRTGLLVDphDPEALAAALRRLldDPALWQRLsragLERAR 384
                         330
                  ....*....|....
gi 1083527485 325 EKFTIEKMVNHYED 338
Cdd:cd03800   385 AHYTWESVADQLLT 398
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
19-338 1.93e-17

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 82.29  E-value: 1.93e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  19 GGVERIVYYLTEGLVKKGHDVTL----------FAPGDSKVSSQVFSTFPFSLGNSGEIKNKPYLPLLQYIdcfkKASGF 88
Cdd:cd03820    13 GGAERVAINLANHLAKKGYDVTIisldsaekppFYELDDNIKIKNLGDRKYSHFKLLLKYFKKVRRLRKYL----KNNKP 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  89 DIIHNHAEHMAMFFADLVT-TPVVHTLHSTL-VEGETLEEKRKVLLRFKNHNFV---SISDNQREGLKELNFAGTVYNGI 163
Cdd:cd03820    89 DVVISFRTSLLTFLALIGLkSKLIVWEHNNYeAYNKGLRRLLLRRLLYKRADKIvvlTEADKLKKYKQPNSNVVVIPNPL 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 164 DIHKYSYIEKPRGDYLLWVGRITRKKGPLSAIEVAKKVS-----IPLVIAAaiDPVEKlffeEEVKPQIDGKTVSFVGEL 238
Cdd:cd03820   169 SFPSEEPSTNLKSKRILAVGRLTYQKGFDLLIEAWALIAkkhpdWKLRIYG--DGPER----EELEKLIDKLGLEDRVKL 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 239 HG--ESLNKLYGNALCTLFPITWhEPFGLVMVESMACGTPVIAYRIGS-TSEVIEDGVTGFIVDDlYQMIEAVKNIDKI- 314
Cdd:cd03820   243 LGptKNIAEEYANSSIFVLSSRY-EGFPMVLLEAMAYGLPIISFDCPTgPSEIIEDGENGLLVPN-GDVDALAEALLRLm 320
                         330       340       350
                  ....*....|....*....|....*....|.
gi 1083527485 315 ----KRKKCRER---VVEKFTIEKMVNHYED 338
Cdd:cd03820   321 edeeLRKKMGKNarkNAERFSIEKIIKQWEE 351
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
19-343 2.79e-17

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 81.61  E-value: 2.79e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  19 GGVERIVYYLTEGLVKKGHDVTLFApGDskvssqvfstfpfslgnsgeikNKPYLPLLQYIDCfkkasgfDIIHNHAEHM 98
Cdd:cd03825    13 GGAARAAYRLHQALLAYGIDSTMLV-GR----------------------KKNLISKPEFIEA-------DIIHLHWIHG 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  99 AMF-FADLV----TTPVVHTLH-----------STLVEGET-----------------------LEEKRKvLLRFKNHNF 139
Cdd:cd03825    63 GYLsLKALFkllrRKPVVWTLHdmwpftggchyPMECEGWKtgcgncpnlnsyppakkdlsrqlFRRKRE-ALAKKRLTI 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 140 VSISD------NQREGLKELNFAgTVYNGIDIHKYSYIEKprgdyllwvgRITRKKgplsaIEVAKKVSIPLVIAAAIDP 213
Cdd:cd03825   142 VAPSRwladmvRRSPLLKGLPVV-VIPNGIDTEIFAPVDK----------AKARKR-----LGIPQDKKVILFGAESVTK 205
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 214 VEKLF--FEEEVK-----------------PQI---DGKTVSFvGELH-GESLNKLYgnALCTLFPI-TWHEPFGLVMVE 269
Cdd:cd03825   206 PRKGFdeLIEALKllatkddlllvvfgkndPQIvilPFDIISL-GYIDdDEQLVDIY--SAADLFVHpSLADNLPNTLLE 282
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 270 SMACGTPVIAYRIGSTSEVIEDGVTGFIV-----DDLYQMIEAVKNIDK---IKRKKCRERVVEKFTIEKMVNHYEDIYS 341
Cdd:cd03825   283 AMACGTPVVAFDTGGSPEIVQHGVTGYLVppgdvQALAEAIEWLLANPKereSLGERARALAENHFDQRVQAQRYLELYK 362

                  ..
gi 1083527485 342 KL 343
Cdd:cd03825   363 DL 364
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
157-340 5.42e-16

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 78.53  E-value: 5.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 157 GTVYNGIDIHKYSYIEKPR----GDYLLWVGRITRKKGPLSAIEVAKKVS--IPLVIAAAIDPV-EKLFFEEEVKPQIDG 229
Cdd:cd03813   270 RVIPNGIDIQRFAPAREERpekePPVVGLVGRVVPIKDVKTFIRAFKLVRraMPDAEGWLIGPEdEDPEYAQECKRLVAS 349
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 230 ----KTVSFVGELH-GESLNKLygnALCTLFPITwhEPFGLVMVESMACGTPVIAYRIGSTSEVIED-----GVTGFIVD 299
Cdd:cd03813   350 lgleNKVKFLGFQNiKEYYPKL---GLLVLTSIS--EGQPLVILEAMASGVPVVATDVGSCRELIYGaddalGQAGLVVP 424
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1083527485 300 --DLYQMIEAVKNI--DKIKR----KKCRERVVEKFTIEKMVNHYEDIY 340
Cdd:cd03813   425 paDPEALAEALIKLlrDPELRqafgEAGRKRVEKYYTLEGMIDSYRKLY 473
GT4_WbaZ-like cd03804
mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 ...
174-327 5.45e-16

mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbaZ in Salmonella enterica has been shown to possess mannosyltransferase activity.


Pssm-ID: 340833 [Multi-domain]  Cd Length: 356  Bit Score: 78.10  E-value: 5.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 174 PRGDYLLWVGRITRKKGPLSAIEVAKKVSIPLVIAAAIDPVEKLffeeevkPQIDGKTVSFVGELHGESLNKLYGNALCT 253
Cdd:cd03804   197 DKEDYYLTASRLVPYKRIDLAVEAFNELPKRLVVIGDGPDLDRL-------RAMASPNVEFLGYQPDEVLKELLSKARAF 269
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 254 LFPITwhEPFGLVMVESMACGTPVIAYRIGSTSEVIEDGVTGFI-----VDDLYQMIEA-VKNIDKIKRKKCRERvVEKF 327
Cdd:cd03804   270 VFAAE--EDFGIVPVEAQACGTPVIAFGKGGALETVRPGPTGILfgeqtVESLKAAVEEfEQNFDRFKPQAIRAN-AERF 346
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
176-308 7.37e-16

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 73.31  E-value: 7.37e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 176 GDYLLWVGRIT-RKKGPLSAIEVakkvsIPLVIAAAIDPveKLFF-----EEEVKPQIDG--KTVSFVGELhgESLNKLY 247
Cdd:pfam13692   1 RPVILFVGRLHpNVKGVDYLLEA-----VPLLRKRDNDV--RLVIvgdgpEEELEELAAGleDRVIFTGFV--EDLAELL 71
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1083527485 248 GNALCTLFPITWhEPFGLVMVESMACGTPVIAYRIGSTSEVIeDGVTGFIV--DDLYQMIEAV 308
Cdd:pfam13692  72 AAADVFVLPSLY-EGFGLKLLEAMAAGLPVVATDVGGIPELV-DGENGLLVppGDPEALAEAI 132
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
17-342 3.45e-15

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 75.56  E-value: 3.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  17 GYGGVERIVYYLTEGLVKKGHDVT-LFAPGDSKVSSQVFSTFPFSLGNSGEIKN--KPYLPLLQYIDCFKKasgfDIIHN 93
Cdd:cd04951    10 GLGGAEKQTVLLADQMFIRGHDVNiVYLTGEVEVKPLNNNIIIYNLGMDKNPRSllKALLKLKKIISAFKP----DVVHS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  94 HAEHmAMFFADLV-----TTPVVHTLHSTLVEGETleekRKVLLRFKNhnFVS-ISDN-QREGLKEL--------NFAGT 158
Cdd:cd04951    86 HMFH-ANIFARFLrmlypIPLLICTAHNKNEGGRI----RMFIYRLTD--FLCdITTNvSREALDEFiakkafskNKSVP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 159 VYNGIDIHKYSY----IEKPRGDY--------LLWVGRITRKK---GPLSAIE--VAKKVSIPLVIA---AAIDPVEKLF 218
Cdd:cd04951   159 VYNGIDLNKFKKdinvRLKIRNKLnlkndefvILNVGRLTEAKdypNLLLAISelILSKNDFKLLIAgdgPLRNELERLI 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 219 FEEEVKpqidgKTVSFVGELhgESLNKLYGNALCTLFPITWhEPFGLVMVESMACGTPVIAYRIGSTSEVIEDGVTGFIV 298
Cdd:cd04951   239 CNLNLV-----DRVILLGQI--SNISEYYNAADLFVLSSEW-EGFGLVVAEAMACERPVVATDAGGVAEVVGDHNYVVPV 310
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1083527485 299 DDLYQMIEAVKNI-------DKIKRKKcRERVVEKFTIEKMVNHYEDIYSK 342
Cdd:cd04951   311 SDPQLLAEKIKEIfdmsdeeRDILGNK-NEYIAKNFSINTIVNEWERLYSG 360
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
2-337 8.24e-14

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 71.60  E-value: 8.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485   2 KIAILAPPYLPIppngYGGVERIVYYLTEGLVKKGHDVTLFAPG-----DSKVSSQVFS-----TFPFSLGNSGeiKNKP 71
Cdd:cd03794     1 KILLISQYYPPP----KGAAAARVYELAKELVRRGHEVTVLTPSpnyplGRIFAGATETkdgirVIRVKLGPIK--KNGL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  72 YLPLLQYID--------CFKKASGFDIIHNHA----EHMAMFFADLVT-TPVVHTLHSTLVEG--ETLEEKRKVLLRFKN 136
Cdd:cd03794    75 IRRLLNYLSfalaallkLLVREERPDVIIAYSppitLGLAALLLKKLRgAPFILDVRDLWPESliALGVLKKGSLLKLLK 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 137 H----------NFVSISDNQREGLKELNFAG----TVYNGID------IHKYSYIEKPRGD---YLLWVGRITRKKGPLS 193
Cdd:cd03794   155 KlerklyrladAIIVLSPGLKEYLLRKGVPKekiiVIPNWADleefkpPPKDELRKKLGLDdkfVVVYAGNIGKAQGLET 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 194 AIEVAKKVS----IPLVIAAAIDPVE--KLFFEEEVKPqidgkTVSFVGELHGESLNKLYGNALCTLFPI-TWHEPFGLV 266
Cdd:cd03794   235 LLEAAERLKrrpdIRFLFVGDGDEKErlKELAKARGLD-----NVTFLGRVPKEEVPELLSAADVGLVPLkDNPANRGSS 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 267 ---MVESMACGTPVIAYRIGSTSEVIEDGVTGFIVD-----DLYQMIEAVKNiDKIKRKKC----RERVVEKFTIEKMVN 334
Cdd:cd03794   310 pskLFEYMAAGKPILASDDGGSDLAVEINGCGLVVEpgdpeALADAILELLD-DPELRRAMgengRELAEEKFSREKLAD 388

                  ...
gi 1083527485 335 HYE 337
Cdd:cd03794   389 RLL 391
Glyco_transf_4 pfam13439
Glycosyltransferase Family 4;
19-165 9.47e-14

Glycosyltransferase Family 4;


Pssm-ID: 463877 [Multi-domain]  Cd Length: 169  Bit Score: 68.33  E-value: 9.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  19 GGVERIVYYLTEGLVKKGHDVTLFAPGDSKVSSQ------VFSTFPFSLGNSGEIKNKPYLPLLQYIdcfkKASGFDIIH 92
Cdd:pfam13439   1 GGVERYVLELARALARRGHEVTVVTPGGPGPLAEevvrvvRVPRVPLPLPPRLLRSLAFLRRLRRLL----RRERPDVVH 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  93 NHAEHMAMFFADLVT----TPVVHTLHSTLVEGETLEEKRKVLLRFKN----------HNFVSISDNQREGLKELNFAG- 157
Cdd:pfam13439  77 AHSPFPLGLAALAARlrlgIPLVVTYHGLFPDYKRLGARLSPLRRLLRrlerrllrraDRVIAVSEAVADELRRLYGVPp 156
                         170
                  ....*....|..
gi 1083527485 158 ----TVYNGIDI 165
Cdd:pfam13439 157 ekirVIPNGVDL 168
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
131-339 2.18e-13

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 70.17  E-value: 2.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 131 LLRFKNHNFVSISDNQREGLKELNF-AGTV---YNGIDIHKYSYIEK-PRGDYLLWVGRITRKKGPLSAIEV-----AKK 200
Cdd:cd05844   139 ALQRPAALFVAVSGFIRDRLLARGLpAERIhvhYIGIDPAKFAPRDPaERAPTILFVGRLVEKKGCDVLIEAfrrlaARH 218
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 201 VSIPLVIAAaiDPVEKLFFEEEVKPqidGKTVSFVGEL-HGESLNKLYGNALCTLFPITW----HEPFGLVMVESMACGT 275
Cdd:cd05844   219 PTARLVIAG--DGPLRPALQALAAA---LGRVRFLGALpHAEVQDWMRRAEIFCLPSVTAasgdSEGLGIVLLEAAACGV 293
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1083527485 276 PVIAYRIGSTSEVIEDGVTGFIV-----DDLYQMIEAVKNIDKIKRK---KCRERVVEKFTIEKMVNHYEDI 339
Cdd:cd05844   294 PVVSSRHGGIPEAILDGETGFLVpegdvDALADALQALLADRALADRmggAARAFVCEQFDIRVQTAKLEAI 365
stp2 TIGR03088
sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match ...
261-344 2.23e-12

sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match to the pfam00534 Glycosyl transferases group 1 domain. Nearly all are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria. In particular, these transferases are found proximal to a particular variant of exosortase, EpsH1, which appears to travel with a conserved group of genes summarized by Genome Property GenProp0652. The nature of the sugar transferase reaction catalyzed by members of this clade is unknown and may conceivably be variable with respect to substrate by species, but we hypothesize a conserved substrate.


Pssm-ID: 132132 [Multi-domain]  Cd Length: 374  Bit Score: 67.44  E-value: 2.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 261 EPFGLVMVESMACGTPVIAYRIGSTSEVIEDGVTGFIV--DDLYQMIEA----VKNIDKIKRKKC--RERVVEKFTIEKM 332
Cdd:TIGR03088 283 EGISNTILEAMASGLPVIATAVGGNPELVQHGVTGALVppGDAVALARAlqpyVSDPAARRAHGAagRARAEQQFSINAM 362
                          90
                  ....*....|..
gi 1083527485 333 VNHYEDIYSKLI 344
Cdd:TIGR03088 363 VAAYAGLYDQLL 374
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
63-343 8.07e-12

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 65.39  E-value: 8.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  63 NSGEIKNKPYLPLLQYIDCFKKASGFDIIHNHAEHMAMFFADL-----VTTPVVHTlHSTLVEGETLEEKRKVLLRFKNH 137
Cdd:cd03812    56 FYIPPKKKNIIKYFIKLLKLIKKEKYDIVHVHGSSSNGIILLLaakagVPVRIAHS-HNTKDSSIKLRKIRKNVLKKLIE 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 138 ----NFVSISDNQREGLKELNFAG---TVYNGIDIHKYSYIEKPRGDYLLW-----------VGRITRKKGPLSAIEVAK 199
Cdd:cd03812   135 rlstKYLACSEDAGEWLFGEVENGkfkVIPNGIDIEKYKFNKEKRRKRRKLliledklvlghVGRFNEQKNHSFLIDIFE 214
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 200 KV-----SIPLVIAAAIDPVEKLffEEEVKPQIDGKTVSFVGELhgESLNKLYGNALCTLFPITWhEPFGLVMVESMACG 274
Cdd:cd03812   215 ELkkknpNVKLVLVGEGELKEKI--KEKVKELGLEDKVIFLGFR--NDVSEILSAMDVFLFPSLY-EGLPLVAVEAQASG 289
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 275 TPVIAYRIGSTSEVIEDGVTGFIVDDLYQM-IEAVKNIDKIKRKKCRERVVEKFtiEKMVNHYEDIYSKL 343
Cdd:cd03812   290 LPCLLSDTITKECDITNNVEFLPLNETPSTwAEKILKLIKRKRRINKEINKEKK--ELGYDDESLELTLL 357
GT4_ALG2-like cd03805
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ...
246-332 5.59e-11

alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.


Pssm-ID: 340834 [Multi-domain]  Cd Length: 392  Bit Score: 62.99  E-value: 5.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 246 LYGNALCTLF-PItwHEPFGLVMVESMACGTPVIAYRIGSTSEVIEDGVTGFIVD-----DLYQMIEAVKNIDKIKR--K 317
Cdd:cd03805   296 LLSSALALLYtPS--NEHFGIVPLEAMYAGKPVIACNSGGPLETVVEGVTGFLCEptpeaFAEAMLKLANDPDLADRmgA 373
                          90
                  ....*....|....*
gi 1083527485 318 KCRERVVEKFTIEKM 332
Cdd:cd03805   374 AGRKRVKEKFSREAF 388
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
219-327 1.24e-08

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 56.26  E-value: 1.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 219 FEEEVKPQIDGKTVSFVGELHGESLNKLYGNALCTLFPiTWHEPFGLVMVESMACGTPVIAYRIGSTSEVI---EDGVTG 295
Cdd:PLN02871  301 YREELEKMFAGTPTVFTGMLQGDELSQAYASGDVFVMP-SESETLGFVVLEAMASGVPVVAARAGGIPDIIppdQEGKTG 379
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1083527485 296 FI-----VDDLYQMIEAVKNIDKIK---RKKCRERvVEKF 327
Cdd:PLN02871  380 FLytpgdVDDCVEKLETLLADPELRermGAAAREE-VEKW 418
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
170-329 1.25e-08

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 55.79  E-value: 1.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 170 YIEKPrgdYLLWVGRITRKKGPLSAIEVAKKV----SIP-LVIA---AAIDPVEKLFFEEEVKPQIDGKTVSFVGELHGE 241
Cdd:cd03792   194 DPERP---YILQVARFDPSKDPLGVIDAYKLFkrraEEPqLVICghgAVDDPEGSVVYEEVMEYAGDDHDIHVLRLPPSD 270
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 242 SL-NKLYGNALCTLFPITwHEPFGLVMVESMACGTPVIAYRIGSTSEVIEDGVTGFIVDD-------LYQMIEAVKNIDK 313
Cdd:cd03792   271 QEiNALQRAATVVLQLST-REGFGLTVSEALWKGKPVIATPAGGIPLQVIDGETGFLVNSvegaavrILRLLTDPELRRK 349
                         170
                  ....*....|....*.
gi 1083527485 314 IkRKKCRERVVEKFTI 329
Cdd:cd03792   350 M-GLAAREHVRDNFLI 364
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
179-337 2.14e-07

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 52.10  E-value: 2.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 179 LLWVGRITRKKGPLSAIEVAKKV-----SIPLVIAAaiDPV-----EKLFFEEEVKPQID--GKTVSFVGELHGESLNKL 246
Cdd:PRK15484  196 LLYAGRISPDKGILLLMQAFEKLatahsNLKLVVVG--DPTasskgEKAAYQKKVLEAAKriGDRCIMLGGQPPEKMHNY 273
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 247 YGNALCTLFPITWHEPFGLVMVESMACGTPVIAYRIGSTSEVIEDGVTGF----------IVDDLYQMIeAVKNIDKIKr 316
Cdd:PRK15484  274 YPLADLVVVPSQVEEAFCMVAVEAMAAGKPVLASTKGGITEFVLEGITGYhlaepmtsdsIISDINRTL-ADPELTQIA- 351
                         170       180
                  ....*....|....*....|.
gi 1083527485 317 KKCRERVVEKFTIEKMVNHYE 337
Cdd:PRK15484  352 EQAKDFVFSKYSWEGVTQRFE 372
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
31-332 8.33e-07

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 50.14  E-value: 8.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  31 GLVKKGHDVTLFA--PGDSKVSSQVFSTFpfslgnsgeikNKPYLPLLQYIDCFKKASGFDIIHNH----------AEHM 98
Cdd:cd03799    23 GLIDRGHEVDIYAvnPGDLVKRHPDVEKY-----------NVPSLNLLYAIVGLNKKGAYDIIHCQfgplgalgalLRRL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  99 AMFFADLVTTpvvhtLHSTLVEGETLEEKRKVLLRF--KNHNFVSISDNQREGL-------KELNFAGTvynGIDIHKYS 169
Cdd:cd03799    92 KVLKGKLVTS-----FRGYDISMYVILEGNKVYPQLfaQGDLFLPNCELFKHRLialgcdeKKIIVHRS---GIDCNKFR 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 170 YieKPRGD------YLLWVGRITRKKGPLSAIEVAKKV-----SIPLVIAAAIDpveklfFEEEVKPQID----GKTVSF 234
Cdd:cd03799   164 F--KPRYLpldgkiRILTVGRLTEKKGLEYAIEAVAKLaqkypNIEYQIIGDGD------LKEQLQQLIQelniGDCVKL 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 235 VGELHGESLNKLYGNALCTLFP-ITW----HEPFGLVMVESMACGTPVIAYRIGSTSEVIEDGVTGFIVDDLYQMIEAVK 309
Cdd:cd03799   236 LGWKPQEEIIEILDEADIFIAPsVTAadgdQDGPPNTLKEAMAMGLPVISTEHGGIPELVEDGVSGFLVPERDAEAIAEK 315
                         330       340       350
                  ....*....|....*....|....*....|.
gi 1083527485 310 NIDKIKR--------KKCRERVVEKFTIEKM 332
Cdd:cd03799   316 LTYLIEHpaiwpemgKAGRARVEEEYDINKL 346
MSMEG_0565_glyc TIGR04047
glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from ...
28-294 2.90e-06

glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274943 [Multi-domain]  Cd Length: 373  Bit Score: 48.55  E-value: 2.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  28 LTEGLVKKGHDVTLFAPGDS--------KVSSQVFstfPFSlGNSGEIKNKPYLPLLQYIDCFKK--ASGFDIIHNH--- 94
Cdd:TIGR04047  21 LAEALTALGHDVTVWALAADgfgffrdpPCAVRLV---PVA-PAPGDTDAMVEQRIARSIDHLRAhfARGFDVVHAQdci 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  95 -AEHMAMFFADLVTTPVVHTLHS----TLVEGETLEEKRKVLLRfknhNFVSISDNQREGLKElNF---AGTVYNGIDIH 166
Cdd:TIGR04047  97 sGNALATLRAEGLIPGFVRTVHHlddfDDPRLAACQERAIVEAD----AVLCVSAAWAAELRA-EWgidATVVPNGVDAA 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 167 KYSYIEKPR------------GDYLLWVGRITRKKGPLSAIE-----VAKKVSIPLVIAAAI-----DPVEKLFFEEEVK 224
Cdd:TIGR04047 172 RFSPAADAAdaalrrrlglrgGPYVLAVGGIEPRKNTIDLLEafallRARRPQAQLVIAGGAtlfdyDAYRREFRARAAE 251
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1083527485 225 PQIDGKTVSFVGELHGESLNKLYGNALCTLFPITwHEPFGLVMVESMACGTPVIAYRIGS-TSEVIEDGVT 294
Cdd:TIGR04047 252 LGVDPGPVVITGPVPDADLPALYRCADAFAFPSL-KEGFGLVVLEALASGIPVVASDIAPfTEYLGRFDAA 321
PLN00142 PLN00142
sucrose synthase
260-299 2.91e-06

sucrose synthase


Pssm-ID: 215073 [Multi-domain]  Cd Length: 815  Bit Score: 49.21  E-value: 2.91e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1083527485 260 HEPFGLVMVESMACGTPVIAYRIGSTSEVIEDGVTGFIVD 299
Cdd:PLN00142  676 YEAFGLTVVEAMTCGLPTFATCQGGPAEIIVDGVSGFHID 715
GT5_Glycogen_synthase_DULL1-like cd03791
Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 ...
261-340 4.45e-06

Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 family of glycosyltransferases. Glycogen synthase (EC:2.4.1.21) catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family includes starch synthases of plants, such as DULL1 in Zea mays and glycogen synthases of various organisms.


Pssm-ID: 340822 [Multi-domain]  Cd Length: 474  Bit Score: 48.33  E-value: 4.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 261 EPFGLVMVESMACGTPVIAYRIGSTSEVIEDGV------TGFIVD--DLYQMIEAVKN-IDKIKRKKCRERVVEK----- 326
Cdd:cd03791   379 EPCGLVQMYAMRYGTLPIVRRTGGLADTVFDYDpetgegTGFVFEdyDAEALLAALRRaLALYRNPELWRKLQKNamkqd 458
                          90
                  ....*....|....
gi 1083527485 327 FTIEKMVNHYEDIY 340
Cdd:cd03791   459 FSWDKSAKEYLELY 472
Glyco_trans_4_4 pfam13579
Glycosyl transferase 4-like domain;
19-122 2.37e-05

Glycosyl transferase 4-like domain;


Pssm-ID: 433325 [Multi-domain]  Cd Length: 158  Bit Score: 43.93  E-value: 2.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485  19 GGVERIVYYLTEGLVKKGHDVTLFAPGDSKVSSQV----FSTFPFSLGNSGEIKNKPYLP--LLQYIdcfkKASGFDIIH 92
Cdd:pfam13579   1 GGIGVYVLELARALAALGHEVRVVTPGGPPGRPELvgdgVRVHRLPVPPRPSPLADLAALrrLRRLL----RAERPDVVH 76
                          90       100       110
                  ....*....|....*....|....*....|...
gi 1083527485  93 NHAEH---MAMFFADLVTTPVVHTLHSTLVEGE 122
Cdd:pfam13579  77 AHSPTaglAARLARRRRGVPLVVTVHGLALDYG 109
GT4-like cd04955
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
176-340 2.89e-05

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in certain bacteria and Archaea.


Pssm-ID: 340858 [Multi-domain]  Cd Length: 379  Bit Score: 45.57  E-value: 2.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 176 GDYLLWVGRITRKKGPLSAIE--VAKKVSIPLVIaaaIDPVEKLFFEEEV--KPQID-GKTVSFVGELH-GESLNKLYGN 249
Cdd:cd04955   208 GKYYLIVGRFVPENNYETMIRefMKSSTKRDLVI---ITNVEGNAYYELLlkKTAFDhDERIKFVGTVYdQELLKYIREN 284
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 250 ALCTLFPitwHEPFGL--VMVESMACGTPVIAYRIGSTSEVIEDGVTGFIVDDLYQMIEAVKNIDKIK----RKKCRERV 323
Cdd:cd04955   285 AFAYLHG---HEVGGTnpSLLEALGSTDLNLLLDVGFNREVAEDAALYWKKEPLASLIDEVDNLNPDEisdlGKKAKQRI 361
                         170
                  ....*....|....*..
gi 1083527485 324 VEKFTIEKMVNHYEDIY 340
Cdd:cd04955   362 EEAYTWEKIVDEYEELF 378
GT4_ExpC-like cd03818
Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 ...
216-299 3.75e-05

Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II).


Pssm-ID: 340845 [Multi-domain]  Cd Length: 396  Bit Score: 45.05  E-value: 3.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 216 KLFFEEEVkpQIDGKTVSFVGELHGESLNKLYGNALCTLFPItwhEPFGLV--MVESMACGTPVIAYRIGSTSEVIEDGV 293
Cdd:cd03818   269 KQKMLAEL--GVDLERVHFVGKVPYDQYVRLLQLSDAHVYLT---YPFVLSwsLLEAMACGCPVIGSDTAPVREVIRDGR 343

                  ....*.
gi 1083527485 294 TGFIVD 299
Cdd:cd03818   344 NGLLVD 349
GT4_AmsK-like cd04946
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ...
220-335 1.76e-04

amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.


Pssm-ID: 340854 [Multi-domain]  Cd Length: 401  Bit Score: 43.22  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 220 EEEVKPQIDGK----TVSFVGELHGESLNKLYGNALCTLF-PITWHEPFGLVMVESMACGTPVIAYRIGSTSEVIEDGVT 294
Cdd:cd04946   269 KERLEKLAENKlenvKVNFTGEVSNKEVKQLYKENDVDVFvNVSESEGIPVSIMEAISFGIPVIATNVGGTREIVENETN 348
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1083527485 295 GFIVDD---LYQMIEAVKNID------KIKRKKCRERVVEKFTIEkmVNH 335
Cdd:cd04946   349 GLLLDKdptPNEIVSSIMKFYldggdyKTMKISARECWEERFNAE--VNY 396
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
261-331 1.97e-04

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 42.67  E-value: 1.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 261 EPFGLVMVESMACGTPVIAYRI--GStSEVIEDGVTGF-----IVDDLYQ-MIEAVKNIDKIKR--KKCRErVVEKFTIE 330
Cdd:cd04949   245 EGFGLTLMEAIGHGLPVVSYDVkyGP-SELIEDGENGYlieknNIDALADkIIELLNDPEKLQQfsEESYK-IAEKYSTE 322

                  .
gi 1083527485 331 K 331
Cdd:cd04949   323 N 323
GT4_ALG11-like cd03806
alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related ...
259-331 5.86e-04

alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown to block the early steps of core biosynthesis that takes place on the cytoplasmic face of the ER and lead to a defect in the assembly of lipid-linked oligosaccharides.


Pssm-ID: 340835 [Multi-domain]  Cd Length: 419  Bit Score: 41.44  E-value: 5.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 259 WHEPFGLVMVESMACGTPVIAYRIGSTSEVI----EDGVTGFIVDDL----YQMIEAVK--NIDKIKRKKCRERVVEKFT 328
Cdd:cd03806   333 WNEHFGIGVVEYMAAGLIPLAHASAGPLLDIvvpwDGGPTGFLASTPeeyaEAIEKILTlsEEERLQRREAARSSAERFS 412

                  ...
gi 1083527485 329 IEK 331
Cdd:cd03806   413 DEE 415
PRK15490 PRK15490
Vi polysaccharide biosynthesis glycosyltransferase TviE;
266-336 7.57e-04

Vi polysaccharide biosynthesis glycosyltransferase TviE;


Pssm-ID: 185387 [Multi-domain]  Cd Length: 578  Bit Score: 41.22  E-value: 7.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1083527485 266 VMVESMACGTPVIAYRIGSTSEVIEDGVTGFIVDDLYQM--------IEAVKNIDKIKRKKCRER---VVEKFTIEKMVN 334
Cdd:PRK15490  488 VLIEAQMVGVPVISTPAGGSAECFIEGVSGFILDDAQTVnldqacryAEKLVNLWRSRTGICQQTqsfLQERFTVEHMVG 567

                  ..
gi 1083527485 335 HY 336
Cdd:PRK15490  568 TF 569
Glyco_trans_1_2 pfam13524
Glycosyl transferases group 1;
269-328 3.99e-03

Glycosyl transferases group 1;


Pssm-ID: 433281 [Multi-domain]  Cd Length: 93  Bit Score: 36.04  E-value: 3.99e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1083527485 269 ESMACGTPVIAYRIGSTSEVIEDGVTGFIVDDLYQMIEAVKN-------IDKIkRKKCRERVVEKFT 328
Cdd:pfam13524  18 EAAACGAPLLTDRTPGLEELFEPGEEILLYRDPEELAEKIRYllehpeeRRAI-AAAGRERVLAEHT 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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