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Concise Results
Standard Results
Full Results
glycyl radical enzyme [Streptococcus sp. HMSC076H07]
Protein Classification
glycyl radical protein ( domain architecture ID 10109344 )
glycyl radical protein similar to formate acetyltransferase, benzylsuccinate synthase, 4-hydroxyphenylacetate decarboxylase, and CutC choline trimethylamine-lyase
List of domain hits
Name
Accession
Description
Interval
E-value
PFL2_DhaB_BssA
cd01677 Pyruvate formate lyase 2 and related enzymes; This family includes pyruvate formate lyase 2 ...
26-815
0e+00
Pyruvate formate lyase 2 and related enzymes; This family includes pyruvate formate lyase 2 (PFL2), B12-independent glycerol dehydratase (DhaB) and the alpha subunit of benzylsuccinate synthase (BssA), all of which have a highly conserved ten-stranded alpha/beta barrel domain, which is similar to those of PFL1 (pyruvate formate lyase 1) and RNR (ribonucleotide reductase). Pyruvate formate lyase catalyzes a key step in anaerobic glycolysis, the conversion of pyruvate and CoenzymeA to formate and acetylCoA. DhaB catalyzes the first step in the conversion of glycerol to 1,3-propanediol while BssA catalyzes the first step in the anaerobic mineralization of both toluene and m-xylene.
Pssm-ID: 153086 [Multi-domain]
Cd Length: 781
Bit Score: 1229.45
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 26 TER MYSYRD K V L DK KP F I DA ERA I L V TE A Y QKHQE KP NVLK RA YM L QN ILE KM TIYI D D ETM IVGN QASSDKDA P I FPE Y 105
Cdd:cd01677 1 TER IKRLKA K I L TA KP S I SI ERA R L Y TE S Y KETEG KP VIIR RA KA L KH ILE NA TIYI Q D DEL IVGN RGGKPRAV P V FPE L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 106 TLEF V VN ELD LFE KR D GD V F Y I T E ET KE QIRN I A P F W ENNN LR A R AGVML PEE VQVY M ET G F F GMEGKMN SG DA H L AV N Y 185
Cdd:cd01677 81 SVHW V ED ELD DLP KR P GD P F V I S E DK KE YLEE I F P Y W KGKT LR D R CFKYF PEE TLIA M AA G V F TEFMYFF SG PG H V AV D Y 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 186 Q K L LE E GL I G FEKK A RK A KAD LDLT K PE S IDK YH FY DSIL I TI EAV K TYA E R F A I LAK KQ A - K TANA KR RQ ELL D IA S IC 264
Cdd:cd01677 161 P K V LE K GL D G LIEE A KE A IEA LDLT G PE D IDK IY FY QAMI I VC EAV I TYA K R Y A E LAK EL A a K ETDP KR KA ELL E IA E IC 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 265 E RVP YY P AK TF A EA V QS V WFI QC ILQIESNGHS L S Y GRFDQY M YP YV K A D L E A GR E T EDSIV E R L TN LWIK TIT INKVRS 344
Cdd:cd01677 241 R RVP AH P PR TF W EA L QS F WFI HL ILQIESNGHS I S P GRFDQY L YP FY K Q D I E E GR L T REGAI E L L EC LWIK INE INKVRS 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 345 Q A HTFSS AG SPLY QN V TIGGQT RHKE DA V N P LS F L V L KSVAQTH LPQP N LTVRYHA NLDKS F MNE A I EV MK LG F G M PAF N 424
Cdd:cd01677 321 G A SAKYF AG YNTF QN L TIGGQT EDGS DA T N E LS Y L I L EATRRVR LPQP S LTVRYHA KSPDK F LKK A A EV IR LG L G Y PAF F 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 425 NDE II IP SFIK KGVS E EDA Y DY SA IGCVET AV PG k WG YR C TG MS YIN FP KVL L IT M NNG I DP A SGK RFA P SY G HF T QMTS 504
Cdd:cd01677 401 NDE VV IP ALLR KGVS L EDA R DY GL IGCVET GA PG - RK YR W TG TG YIN LA KVL E IT L NNG K DP R SGK QVG P ET G DA T DFKT 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 505 YK EL K EA WD K T LR YLTRM SV IVE N AI DI SLEREV P DILC SAL T D N CI GR GK HLKE GGA V Y DYISGLQ VGIA N L S DSLAA L 584
Cdd:cd01677 480 FE EL W EA FK K Q LR HFIKL SV RAN N IS DI AHAEVA P APFL SAL V D D CI EK GK DINA GGA R Y NFGGIQG VGIA T L G DSLAA I 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 585 KKLVFEEK R LT TL E VWQ AL QSDY A G pr G E E I R QM L I N E APKYGNDDDYAD SLV R EC Y DV Y VE E IA KY P N trygrg P I GG I 664
Cdd:cd01677 560 KKLVFEEK K LT ME E LLE AL KANF A E -- G Y E E R RR L L N N APKYGNDDDYAD NIA R RV Y EW Y CK E VE KY Q N ------ P R GG K 631
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 665 R Y S GT S S I SANV GQ G RG T L ATPDGR H AGTPL AE G C SPS HNM DKKGPT S V L KSVSKL PTDE I V GG V LLNQK VN P Q TL AK EE 744
Cdd:cd01677 632 F Y P GT Y S V SANV PF G SV T G ATPDGR L AGTPL SD G V SPS QGT DKKGPT A V I KSVSKL DHFN I S GG T LLNQK FS P S TL EG EE 711
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1080853602 745 DKQ KL I AL L RT F F n R L H G Y HIQ Y NVVS R ETL I DAQKHPEK H RDLIVRVAGYSA F F NV LSK AT QD D IIARTE 815
Cdd:cd01677 712 GLK KL A AL I RT Y F - D L G G H HIQ F NVVS A ETL R DAQKHPEK Y RDLIVRVAGYSA Y F VE LSK EV QD E IIARTE 781
Name
Accession
Description
Interval
E-value
PFL2_DhaB_BssA
cd01677 Pyruvate formate lyase 2 and related enzymes; This family includes pyruvate formate lyase 2 ...
26-815
0e+00
Pyruvate formate lyase 2 and related enzymes; This family includes pyruvate formate lyase 2 (PFL2), B12-independent glycerol dehydratase (DhaB) and the alpha subunit of benzylsuccinate synthase (BssA), all of which have a highly conserved ten-stranded alpha/beta barrel domain, which is similar to those of PFL1 (pyruvate formate lyase 1) and RNR (ribonucleotide reductase). Pyruvate formate lyase catalyzes a key step in anaerobic glycolysis, the conversion of pyruvate and CoenzymeA to formate and acetylCoA. DhaB catalyzes the first step in the conversion of glycerol to 1,3-propanediol while BssA catalyzes the first step in the anaerobic mineralization of both toluene and m-xylene.
Pssm-ID: 153086 [Multi-domain]
Cd Length: 781
Bit Score: 1229.45
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 26 TER MYSYRD K V L DK KP F I DA ERA I L V TE A Y QKHQE KP NVLK RA YM L QN ILE KM TIYI D D ETM IVGN QASSDKDA P I FPE Y 105
Cdd:cd01677 1 TER IKRLKA K I L TA KP S I SI ERA R L Y TE S Y KETEG KP VIIR RA KA L KH ILE NA TIYI Q D DEL IVGN RGGKPRAV P V FPE L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 106 TLEF V VN ELD LFE KR D GD V F Y I T E ET KE QIRN I A P F W ENNN LR A R AGVML PEE VQVY M ET G F F GMEGKMN SG DA H L AV N Y 185
Cdd:cd01677 81 SVHW V ED ELD DLP KR P GD P F V I S E DK KE YLEE I F P Y W KGKT LR D R CFKYF PEE TLIA M AA G V F TEFMYFF SG PG H V AV D Y 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 186 Q K L LE E GL I G FEKK A RK A KAD LDLT K PE S IDK YH FY DSIL I TI EAV K TYA E R F A I LAK KQ A - K TANA KR RQ ELL D IA S IC 264
Cdd:cd01677 161 P K V LE K GL D G LIEE A KE A IEA LDLT G PE D IDK IY FY QAMI I VC EAV I TYA K R Y A E LAK EL A a K ETDP KR KA ELL E IA E IC 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 265 E RVP YY P AK TF A EA V QS V WFI QC ILQIESNGHS L S Y GRFDQY M YP YV K A D L E A GR E T EDSIV E R L TN LWIK TIT INKVRS 344
Cdd:cd01677 241 R RVP AH P PR TF W EA L QS F WFI HL ILQIESNGHS I S P GRFDQY L YP FY K Q D I E E GR L T REGAI E L L EC LWIK INE INKVRS 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 345 Q A HTFSS AG SPLY QN V TIGGQT RHKE DA V N P LS F L V L KSVAQTH LPQP N LTVRYHA NLDKS F MNE A I EV MK LG F G M PAF N 424
Cdd:cd01677 321 G A SAKYF AG YNTF QN L TIGGQT EDGS DA T N E LS Y L I L EATRRVR LPQP S LTVRYHA KSPDK F LKK A A EV IR LG L G Y PAF F 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 425 NDE II IP SFIK KGVS E EDA Y DY SA IGCVET AV PG k WG YR C TG MS YIN FP KVL L IT M NNG I DP A SGK RFA P SY G HF T QMTS 504
Cdd:cd01677 401 NDE VV IP ALLR KGVS L EDA R DY GL IGCVET GA PG - RK YR W TG TG YIN LA KVL E IT L NNG K DP R SGK QVG P ET G DA T DFKT 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 505 YK EL K EA WD K T LR YLTRM SV IVE N AI DI SLEREV P DILC SAL T D N CI GR GK HLKE GGA V Y DYISGLQ VGIA N L S DSLAA L 584
Cdd:cd01677 480 FE EL W EA FK K Q LR HFIKL SV RAN N IS DI AHAEVA P APFL SAL V D D CI EK GK DINA GGA R Y NFGGIQG VGIA T L G DSLAA I 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 585 KKLVFEEK R LT TL E VWQ AL QSDY A G pr G E E I R QM L I N E APKYGNDDDYAD SLV R EC Y DV Y VE E IA KY P N trygrg P I GG I 664
Cdd:cd01677 560 KKLVFEEK K LT ME E LLE AL KANF A E -- G Y E E R RR L L N N APKYGNDDDYAD NIA R RV Y EW Y CK E VE KY Q N ------ P R GG K 631
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 665 R Y S GT S S I SANV GQ G RG T L ATPDGR H AGTPL AE G C SPS HNM DKKGPT S V L KSVSKL PTDE I V GG V LLNQK VN P Q TL AK EE 744
Cdd:cd01677 632 F Y P GT Y S V SANV PF G SV T G ATPDGR L AGTPL SD G V SPS QGT DKKGPT A V I KSVSKL DHFN I S GG T LLNQK FS P S TL EG EE 711
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1080853602 745 DKQ KL I AL L RT F F n R L H G Y HIQ Y NVVS R ETL I DAQKHPEK H RDLIVRVAGYSA F F NV LSK AT QD D IIARTE 815
Cdd:cd01677 712 GLK KL A AL I RT Y F - D L G G H HIQ F NVVS A ETL R DAQKHPEK Y RDLIVRVAGYSA Y F VE LSK EV QD E IIARTE 781
PflD
COG1882 Pyruvate-formate lyase [Energy production and conversion]; Pyruvate-formate lyase is part of ...
19-816
0e+00
Pyruvate-formate lyase [Energy production and conversion]; Pyruvate-formate lyase is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 441486 [Multi-domain]
Cd Length: 789
Bit Score: 1106.37
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 19 QKHFGYL TER MYSY R D K V L DK KP F ID A ERA I L V TE A Y QKHQEK P NVLK RA YMLQN ILE KMT IYI D D ETM IVG N Q ASSDKD 98
Cdd:COG1882 1 ESFLAGP TER TKRL R E K L L EA KP L ID I ERA R L F TE S Y KETEGL P VIIR RA KAFSH ILE HKP IYI K D DEL IVG L Q TDKPRK 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 99 A PIFPE YTLEF V VN ELD LFEK R DG D V F Y I TE E T KE QI R N IAP F W ENNNLRARAGVML PEE VQVYMET G FFG m EGKMNS G D 178
Cdd:COG1882 81 R PIFPE GGIRW V ED ELD ALPT R PQ D G F E I SP E D KE IF R E IAP Y W KGKTHNDGVFDAY PEE IRKARKA G IIT - GLPDAY G R 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 179 A H LAVN Y QKL L EE GL I G FEKK A RKAK A D LDLT K PE S I D K YH FY DSIL I TI EAV KTY AER F A I LA KKQ A - K TANA KR RQ EL 257
Cdd:COG1882 160 G H IIGD Y RRV L LY GL D G LIEE A KEKL A E LDLT D PE D I E K ID FY KAMI I VC EAV IRL AER Y A E LA REL A e K ETDP KR KA EL 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 258 L D IA S IC ER VP YY PA K TF A EAVQ S VWF IQCILQI E S NG HSL S Y GRFDQY M YPY VKA DLE A GR E TE DSIV E R L TNL WIK TI 337
Cdd:COG1882 240 L E IA E IC GF VP AN PA R TF W EAVQ W VWF VYLAAIK E Q NG AAM S L GRFDQY L YPY YER DLE E GR L TE EEAQ E L L DCF WIK LR 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 338 TINKV R SQAHTFSS AG S P LYQNV TIGG Q T RHKE DAVN P LS F L V L KSVAQTH LP Q PNLTVR YHAN L DKS F MNE A I EV MKL G 417
Cdd:COG1882 320 EVRFL R TPEYAELF AG Y P TWVTL TIGG M T PDGR DAVN E LS Y L I L ETLRNLP LP E PNLTVR WSEK L PEG F LKK A A EV ISI G 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 418 F G M P AFN ND EII IP SFIK KGV SE EDA Y DY SAI GCVE TA VPGK W g YRCT G MSY IN FP K V L LITM NNG I D PAS GK RFA P SY G 497
Cdd:COG1882 400 T G S P QYE ND DLM IP MLLN KGV TL EDA R DY GIA GCVE PM VPGK Q - MQFF G AGR IN LA K A L EYAL NNG V D EKT GK QVG P ET G 478
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 498 HF T QMTS Y K E LK EA WD K T L R YL TRMS V IVE N A I DISLEREV P DILC SAL T D N CI G RGK H L K EGGA V Y DYISGLQV G IANL 577
Cdd:COG1882 479 DP T DFLT Y D E VM EA FK K Q L D YL ADLY V NAL N I I HYMHDKYA P EPFL SAL H D D CI E RGK D L N EGGA R Y NFGAIGIA G LSVV 558
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 578 S DSL A A L KKLVF EE K RL T TL E VWQ AL QSDYA G pr G EE I RQ M L I N e APKYGNDDDY A D SLVR E CYDVYVE EI A KY PNT R yg 657
Cdd:COG1882 559 A DSL S A I KKLVF DK K KV T MD E LLE AL AANFE G -- Y EE L RQ L L L N - APKYGNDDDY V D EIAV E LVETFMD EI R KY KTY R -- 633
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 658 rgpi GG IRYSGTSS I SA NV GQ G RG T L ATPDGR H AG T PLA E G C SP S H NM DK K GPT S VLKSV S KLP TDEIVG G V LLNQK VN P 737
Cdd:COG1882 634 ---- GG TYTLSILT I TS NV PY G KK T G ATPDGR K AG E PLA D G A SP M H GR DK N GPT A VLKSV A KLP YEKATD G I LLNQK FS P 709
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1080853602 738 QT L AK EE DKQK L IA LLRT F F N r L H G Y HIQ Y NVV S RETL I DAQKHPEK HR DL I VRVAGYSA F F NV LSK AT QDDIIARTEH 816
Cdd:COG1882 710 SA L GG EE GIEN L VS LLRT Y F D - L G G H HIQ F NVV D RETL L DAQKHPEK YP DL T VRVAGYSA Y F VE LSK EQ QDDIIARTEH 787
PFL2-3
TIGR01774 glycyl radical enzyme, PFL2/glycerol dehydratase family; This family previously was designated ...
25-818
0e+00
glycyl radical enzyme, PFL2/glycerol dehydratase family; This family previously was designated pyruvate formate-lyase, but it now appears that members include the B12-independent glycerol dehydratase. Therefore, the functional definition of the family is being broadened. This family includes the PflF and PflD proteins of E. coli, described as isoforms of pyruvate-formate lyase found in a limited number additional species. PFL catalyzes the reaction pyruvate + CoA -> acetyl-CoA + formate, which is a step in the fermentation of glucose.
Pssm-ID: 273798 [Multi-domain]
Cd Length: 786
Bit Score: 875.00
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 25 LTE R MYSYRDKVLDKKPFIDA ERA I L V TE AYQKHQEK P NVLK RA YM L QNI LE KMT I Y I D D ETM IVGN QASSDKD A P IFPE 104
Cdd:TIGR01774 2 CMD R IEKLKKALSKPVARLSV ERA R L Y TE SMKQTEGE P MIIR RA KA L AHV LE NIP I Q I L D SEL IVGN MLPNPRA A I IFPE 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 105 YTLEFVVN ELD LFEK R DGDV F YIT EE T K EQI R N - IAP F W ENNNLRAR A GVMLPE E VQVYME T GF F GME G k MNS G DA H L AV 183
Cdd:TIGR01774 82 GVGLWIIK ELD SLPN R PTNR F AVS EE D K RVL R E e IAP Y W QRKTIEDF A FGLMTD E MKILYT T SI F VLT G - EIA G IS H V AV 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 184 NY QK LL EE GL IGFEKKARKAKAD L DLTKPESID KY H FY DSIL I TI EAV KTYAE R F A I LA KKQ A KTAN - AK RR Q ELL D IA S 262
Cdd:TIGR01774 161 NY PY LL RR GL RWLLEESERRIRA L EESGVYEGE KY S FY QAAK I VL EAV INHIL R Y A K LA EEM A ASET g ES RR E ELL K IA E 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 263 IC ER V PYYPAK TF AE AVQ S VW FI Q C ILQ I ESN GH S L S Y GR F DQY M YP YV K A D LEA GR ETEDSIV E R L TN LWIKT IT I NKV 342
Cdd:TIGR01774 241 IC RK V AAEKPQ TF WQ AVQ L VW LV Q S ILQ Q ESN EQ S I S M GR I DQY L YP FY K K D IGE GR IDRELAF E I L AS LWIKT NE I VPA 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 343 RS QAHTFSS AG S P LY Q N VTIGG QTRHKE DAVN P LS F L V L KSVAQTH L P QPNL T VR YH A NLDK SF MNEAI E VMKL G F G M PA 422
Cdd:TIGR01774 321 RS SSLEQYF AG Q P TN Q A VTIGG CDIYGN DAVN E LS Y L M L EVTDRLR L R QPNL H VR IN A GSPE SF LKRLA E AIRS G C G N PA 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 423 FN NDE III P S F IKK GV SEE DA Y DY SAI GCVE T A VP G KW g Y RCTGMSY IN FP KV LLITM N N G I D PAS G KR F APSY ghf TQM 502
Cdd:TIGR01774 401 LF NDE AVV P A F KNA GV DDR DA L DY TTD GCVE I A PF G NS - Y TSSDAAL IN VA KV MEYAL N E G V D LQF G YE F GAKT --- EKP 476
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 503 TSYKE L K E AWDKTLRYLTRMS V IVE N AI D ISLEREV P DI L C S ALTDN C IGR G KHLKE GGA V Y DYISGLQ VGIANL S DSL A 582
Cdd:TIGR01774 477 KFLED L L E KLREQISHYVKLV V EGS N VL D YANAEVK P TP L L S LCVED C FEK G VDISR GGA R Y NFTGIQA VGIANL G DSL V 556
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 583 A L K KL VFE EKRLTTLEVWQ AL QSDYA G PRG EE I R QM LIN EA PKYGNDDD YA D SLVRECYDV Y V EE IAK Y P N T R ygrgpi G 662
Cdd:TIGR01774 557 A I K GA VFE QGAYSMDDLVE AL RKNFV G LTH EE K R HR LIN QS PKYGNDDD AV D KYTAMVLEW Y C EE VNR Y R N P R ------ G 630
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 663 G IRYS G TSSI SANV GQ G RG T L ATPDGR H AG T PLA E G C SPS HN MD KK GPT S V LK SVSKL PTDEIVG G V LLN Q K VN P Q TL AK 742
Cdd:TIGR01774 631 G KFAA G CYPM SANV PF G FF T S ATPDGR K AG E PLA P G V SPS TG MD RE GPT A V IN SVSKL SYENLPN G A LLN I K LS P A TL EE 710
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1080853602 743 E E DKQKLI AL LR TF F NR L HGY HIQ Y N V V SRE TL ID AQ KH PEK H R D L I VRVAGYSAFF NV LS KAT QDDII A RT E H A L 818
Cdd:TIGR01774 711 E G DKQKLI EA LR KS F ME L KVM HIQ F N I V KED TL RK AQ QE PEK Y R W L V VRVAGYSAFF VE LS RPV QDDII R RT S H R L 786
PFL-like
pfam02901 Pyruvate formate lyase-like; This family of enzymes includes pyruvate formate lyase, choline ...
25-679
0e+00
Pyruvate formate lyase-like; This family of enzymes includes pyruvate formate lyase, choline trimethylamine lyase, glycerol dehydratase, 4-hydroxyphenylacetate decarboxylase, and benzylsuccinate synthase.
Pssm-ID: 427048
Cd Length: 647
Bit Score: 727.12
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 25 LT ER MYSYRDKVL -- DKK P FIDA ERA I L V TE A Y QKHQ - EK P NVLK RA YM L QN IL EKMTI YI D D ETM IVG N Q ASSDKDAP I 101
Cdd:pfam02901 1 MW ER IDVLKENYT ly TGD P SLSW ERA R L L TE S Y KETE g VL P VDIR RA KA L KK IL SHLPG YI R D DEL IVG L Q TDKPRKRA I 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 102 F PE YTLEF V VN ELD LFEK R DG D V F Y I T EE T K EQI R N I A P F W ENNNLRARAGVMLPE E VQVYM E T G F F g MEGKMNS G DA H L 181
Cdd:pfam02901 81 Y PE GGIRW V ED ELD YLNT R PQ D G F E I S EE D K KIF R E I F P Y W KGKTHNEGVFDAYTP E MKAAR E S G I F - TGLPDAY G RG H I 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 182 AVN Y QKL L EE GL I G FEKKARKAK A D LD l T K PE S I D K YH FY DSIL I TIE AV KT YAER F A I LA KKQ A - KTANA KR RQ ELL D I 260
Cdd:pfam02901 160 IGD Y RRV L LY GL D G LIEEKEEKL A K LD - T D PE D I E K IE FY KAMI I SCD AV IE YAER Y A R LA EEL A e QETDP KR KA ELL E I 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 261 A S IC E RVP YY PA K TF A EA V Q SV WF IQCILQI E S NG HSL S Y GR F DQY M YPY VKA DLE A GR E TE DSIV E RLTNL WIK TITIN 340
Cdd:pfam02901 239 A E IC G RVP AR PA E TF Q EA I Q WF WF VYLAAVK E Q NG AAM S L GR L DQY L YPY YER DLE E GR L TE EEAQ E LIDCF WIK LREVR 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 341 KV R SQAHTFSS AG SPLY QN V TIGGQ T R HKE DAVN P LS F L V L KSVAQTH LP Q PNLTVR YHAN L DKS F MNE A I EV MKL G F G M 420
Cdd:pfam02901 319 FL R TPEYNKLF AG YDPF QN L TIGGQ G R DGR DAVN K LS Y L I L EALDNLP LP E PNLTVR WSKK L PEE F LKK A A EV SRK G T G S 398
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 421 P AFN ND EII IP SFIKK GVS E EDA Y DY SAI GCVE TAV PGK - WGYRC tgm SY IN FP K V L LITM N N G I D PAS GK RFA P SY G HF 499
Cdd:pfam02901 399 P QYE ND DVM IP ALLNR GVS L EDA R DY GIA GCVE PMK PGK e MQFFG --- AR IN LA K A L EYAL N G G R D ELT GK QVG P KT G PV 475
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 500 T QMT S YK E LK EA WD K T L R YL TRMS V IVE N A I DISLEREV P DILC SAL T D N CI G RGK HLKE GGA V Y DYISGLQV G I AN LS D 579
Cdd:pfam02901 476 T EFL S FE E VM EA FK K Q L D YL ADLY V NAL N I I HYMHDKYA P EPFL SAL H D D CI E RGK DVGI GGA R Y NFSGPQGA G L AN VA D 555
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 580 SL A A L KKLVF EE K RL T TL E VWQ AL QS D YA G P rg EE I RQ M L I N E APKYGNDDD YA D SLVR E CYDVYVE E IA KY P N T R ygrg 659
Cdd:pfam02901 556 SL S A I KKLVF DD K VY T LR E LED AL AA D FE G E -- EE L RQ D L L N D APKYGNDDD RV D DIAV E VVETFMD E VR KY K N Y R ---- 629
650 660
....*....|....*....|
gi 1080853602 660 pi GG IRYSGTSS I SA NV GQ G 679
Cdd:pfam02901 630 -- GG KFTPSLLT I TS NV PY G 647
pflD
PRK09983 putative formate acetyltransferase 2; Provisional
25-818
0e+00
putative formate acetyltransferase 2; Provisional
Pssm-ID: 182181 [Multi-domain]
Cd Length: 765
Bit Score: 565.21
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 25 L T E R MYSYRDKVLDKKPF I DA ERA I L V T EAYQKHQEK P NV L K RA YMLQN ILE KMT I Y I D DE TM I V GN QASSDKDAPIF PE 104
Cdd:PRK09983 1 M T N R ISRLKTALFANTRE I SL ERA L L Y T ASHRQTEGE P VI L R RA KATAY ILE HVE I S I R DE EL I A GN RTVKPRAGIMS PE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 105 YTLEFVVN ELD L F EK R DG D V F Y I T EE T K EQI R N - IA P F WE NNNLRARAGVMLPE EV QVYME T GF F GME g KMNS G DA H LAV 183
Cdd:PRK09983 81 MDPYWLLK ELD Q F PT R PQ D R F A I S EE D K RIY R E e LF P Y WE KRSMKDFINGQMTD EV KAATS T QI F SIN - QTDK G QG H III 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 184 N Y QK LL EE GL IGFEKKARKAKAD ldlt K PE S idky HFY DSI L ITI EA VKTYAE R F A I LA KKQ A KT - AN A K RR Q ELL D IA S 262
Cdd:PRK09983 160 D Y PR LL NH GL GELVAQMQQHCQQ ---- Q PE N ---- HFY QAA L LLL EA SQKHIL R Y A E LA ETM A AN c TD A Q RR E ELL T IA E 231
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 263 I CERVPYYPAK TF AE A V Q SV W FIQC ILQ I ESN GH SLS Y GRFDQYM Y P YVK A D L EA G r E TEDSIV E R L TN LW I K TIT I NKV 342
Cdd:PRK09983 232 I SRHNAQHKPQ TF WQ A C Q LF W YMNI ILQ Y ESN AS SLS L GRFDQYM L P FYQ A S L TQ G - E DPAFLK E L L ES LW V K CND I VLL 310
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 343 RS QAHTFSS AG S P LYQNVTI GG Q T RHKED AVN P LSFL V L KSVAQTH LPQPNL T VR YH A NL D KS F MNEAI E VMK LG F G M P A 422
Cdd:PRK09983 311 RS TSSARYF AG F P TGYTALL GG L T ENGRS AVN V LSFL C L DAYQSVQ LPQPNL G VR TN A LI D TP F LMKTA E TIR LG T G I P Q 390
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 423 FN NDE III P S F IKK GVS E EDA Y DYS AI GCVE TAV PG K w G Y RCTGMSYI N FP KV LL I TM -- N N G IDP asgkrfapsyghft 500
Cdd:PRK09983 391 IF NDE VVV P A F LNR GVS L EDA R DYS VV GCVE LSI PG R - T Y GLHDIAMF N LL KV ME I CL he N E G NAA -------------- 455
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 501 qm TS Y KE L K E AWDKTLRYLTRMS V IVE N AI DI SLEREV P DI L C S ALTDN C IGR G KHLKE GGA V Y DY i SG L Q - V GIANLSD 579
Cdd:PRK09983 456 -- LT Y EG L L E QIRAKISHYITLM V EGS N IC DI GHRDWA P VP L L S SFISD C LEK G RDITD GGA R Y NF - SG V Q g I GIANLSD 532
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 580 SL A ALK KL VF EEK RL TTL E VWQA L QSDY A G P R GE EI R QM LIN EAP KYGND D D YA D SLVR E CYDV Y VE E IA KY P N T R ygrg 659
Cdd:PRK09983 533 SL H ALK GM VF DQQ RL SFD E LLSV L KANF A T P E GE KV R AR LIN RFE KYGND I D EV D NISA E LLRH Y CK E VE KY Q N P R ---- 608
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 660 pi GG IRYS G TSSI SA N V GQ G RGTL ATPDGR H AG TP LA E - G C SP SHNM D KK GPT S VLKSVSKL PTDEIVG G V LLN Q K VN P Q 738
Cdd:PRK09983 609 -- GG YFTP G SYTV SA H V PL G SVVG ATPDGR F AG EQ LA D g G L SP MLGQ D AQ GPT A VLKSVSKL DNTLLSN G T LLN V K FT P A 686
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 739 TL AK E EDKQ KL IAL LR T f F NR L HGY HIQ Y NVV SRE TL ID AQ KH P EKHRD L I VRVAGYSAFF NV LSK AT QDDII A RT E H A L 818
Cdd:PRK09983 687 TL EG E AGLR KL ADF LR A - F TQ L KLQ HIQ F NVV NAD TL RE AQ QR P QDYAG L V VRVAGYSAFF VE LSK EI QDDII R RT A H Q L 765
Name
Accession
Description
Interval
E-value
PFL2_DhaB_BssA
cd01677 Pyruvate formate lyase 2 and related enzymes; This family includes pyruvate formate lyase 2 ...
26-815
0e+00
Pyruvate formate lyase 2 and related enzymes; This family includes pyruvate formate lyase 2 (PFL2), B12-independent glycerol dehydratase (DhaB) and the alpha subunit of benzylsuccinate synthase (BssA), all of which have a highly conserved ten-stranded alpha/beta barrel domain, which is similar to those of PFL1 (pyruvate formate lyase 1) and RNR (ribonucleotide reductase). Pyruvate formate lyase catalyzes a key step in anaerobic glycolysis, the conversion of pyruvate and CoenzymeA to formate and acetylCoA. DhaB catalyzes the first step in the conversion of glycerol to 1,3-propanediol while BssA catalyzes the first step in the anaerobic mineralization of both toluene and m-xylene.
Pssm-ID: 153086 [Multi-domain]
Cd Length: 781
Bit Score: 1229.45
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 26 TER MYSYRD K V L DK KP F I DA ERA I L V TE A Y QKHQE KP NVLK RA YM L QN ILE KM TIYI D D ETM IVGN QASSDKDA P I FPE Y 105
Cdd:cd01677 1 TER IKRLKA K I L TA KP S I SI ERA R L Y TE S Y KETEG KP VIIR RA KA L KH ILE NA TIYI Q D DEL IVGN RGGKPRAV P V FPE L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 106 TLEF V VN ELD LFE KR D GD V F Y I T E ET KE QIRN I A P F W ENNN LR A R AGVML PEE VQVY M ET G F F GMEGKMN SG DA H L AV N Y 185
Cdd:cd01677 81 SVHW V ED ELD DLP KR P GD P F V I S E DK KE YLEE I F P Y W KGKT LR D R CFKYF PEE TLIA M AA G V F TEFMYFF SG PG H V AV D Y 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 186 Q K L LE E GL I G FEKK A RK A KAD LDLT K PE S IDK YH FY DSIL I TI EAV K TYA E R F A I LAK KQ A - K TANA KR RQ ELL D IA S IC 264
Cdd:cd01677 161 P K V LE K GL D G LIEE A KE A IEA LDLT G PE D IDK IY FY QAMI I VC EAV I TYA K R Y A E LAK EL A a K ETDP KR KA ELL E IA E IC 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 265 E RVP YY P AK TF A EA V QS V WFI QC ILQIESNGHS L S Y GRFDQY M YP YV K A D L E A GR E T EDSIV E R L TN LWIK TIT INKVRS 344
Cdd:cd01677 241 R RVP AH P PR TF W EA L QS F WFI HL ILQIESNGHS I S P GRFDQY L YP FY K Q D I E E GR L T REGAI E L L EC LWIK INE INKVRS 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 345 Q A HTFSS AG SPLY QN V TIGGQT RHKE DA V N P LS F L V L KSVAQTH LPQP N LTVRYHA NLDKS F MNE A I EV MK LG F G M PAF N 424
Cdd:cd01677 321 G A SAKYF AG YNTF QN L TIGGQT EDGS DA T N E LS Y L I L EATRRVR LPQP S LTVRYHA KSPDK F LKK A A EV IR LG L G Y PAF F 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 425 NDE II IP SFIK KGVS E EDA Y DY SA IGCVET AV PG k WG YR C TG MS YIN FP KVL L IT M NNG I DP A SGK RFA P SY G HF T QMTS 504
Cdd:cd01677 401 NDE VV IP ALLR KGVS L EDA R DY GL IGCVET GA PG - RK YR W TG TG YIN LA KVL E IT L NNG K DP R SGK QVG P ET G DA T DFKT 479
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 505 YK EL K EA WD K T LR YLTRM SV IVE N AI DI SLEREV P DILC SAL T D N CI GR GK HLKE GGA V Y DYISGLQ VGIA N L S DSLAA L 584
Cdd:cd01677 480 FE EL W EA FK K Q LR HFIKL SV RAN N IS DI AHAEVA P APFL SAL V D D CI EK GK DINA GGA R Y NFGGIQG VGIA T L G DSLAA I 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 585 KKLVFEEK R LT TL E VWQ AL QSDY A G pr G E E I R QM L I N E APKYGNDDDYAD SLV R EC Y DV Y VE E IA KY P N trygrg P I GG I 664
Cdd:cd01677 560 KKLVFEEK K LT ME E LLE AL KANF A E -- G Y E E R RR L L N N APKYGNDDDYAD NIA R RV Y EW Y CK E VE KY Q N ------ P R GG K 631
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 665 R Y S GT S S I SANV GQ G RG T L ATPDGR H AGTPL AE G C SPS HNM DKKGPT S V L KSVSKL PTDE I V GG V LLNQK VN P Q TL AK EE 744
Cdd:cd01677 632 F Y P GT Y S V SANV PF G SV T G ATPDGR L AGTPL SD G V SPS QGT DKKGPT A V I KSVSKL DHFN I S GG T LLNQK FS P S TL EG EE 711
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1080853602 745 DKQ KL I AL L RT F F n R L H G Y HIQ Y NVVS R ETL I DAQKHPEK H RDLIVRVAGYSA F F NV LSK AT QD D IIARTE 815
Cdd:cd01677 712 GLK KL A AL I RT Y F - D L G G H HIQ F NVVS A ETL R DAQKHPEK Y RDLIVRVAGYSA Y F VE LSK EV QD E IIARTE 781
PflD
COG1882 Pyruvate-formate lyase [Energy production and conversion]; Pyruvate-formate lyase is part of ...
19-816
0e+00
Pyruvate-formate lyase [Energy production and conversion]; Pyruvate-formate lyase is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 441486 [Multi-domain]
Cd Length: 789
Bit Score: 1106.37
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 19 QKHFGYL TER MYSY R D K V L DK KP F ID A ERA I L V TE A Y QKHQEK P NVLK RA YMLQN ILE KMT IYI D D ETM IVG N Q ASSDKD 98
Cdd:COG1882 1 ESFLAGP TER TKRL R E K L L EA KP L ID I ERA R L F TE S Y KETEGL P VIIR RA KAFSH ILE HKP IYI K D DEL IVG L Q TDKPRK 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 99 A PIFPE YTLEF V VN ELD LFEK R DG D V F Y I TE E T KE QI R N IAP F W ENNNLRARAGVML PEE VQVYMET G FFG m EGKMNS G D 178
Cdd:COG1882 81 R PIFPE GGIRW V ED ELD ALPT R PQ D G F E I SP E D KE IF R E IAP Y W KGKTHNDGVFDAY PEE IRKARKA G IIT - GLPDAY G R 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 179 A H LAVN Y QKL L EE GL I G FEKK A RKAK A D LDLT K PE S I D K YH FY DSIL I TI EAV KTY AER F A I LA KKQ A - K TANA KR RQ EL 257
Cdd:COG1882 160 G H IIGD Y RRV L LY GL D G LIEE A KEKL A E LDLT D PE D I E K ID FY KAMI I VC EAV IRL AER Y A E LA REL A e K ETDP KR KA EL 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 258 L D IA S IC ER VP YY PA K TF A EAVQ S VWF IQCILQI E S NG HSL S Y GRFDQY M YPY VKA DLE A GR E TE DSIV E R L TNL WIK TI 337
Cdd:COG1882 240 L E IA E IC GF VP AN PA R TF W EAVQ W VWF VYLAAIK E Q NG AAM S L GRFDQY L YPY YER DLE E GR L TE EEAQ E L L DCF WIK LR 319
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 338 TINKV R SQAHTFSS AG S P LYQNV TIGG Q T RHKE DAVN P LS F L V L KSVAQTH LP Q PNLTVR YHAN L DKS F MNE A I EV MKL G 417
Cdd:COG1882 320 EVRFL R TPEYAELF AG Y P TWVTL TIGG M T PDGR DAVN E LS Y L I L ETLRNLP LP E PNLTVR WSEK L PEG F LKK A A EV ISI G 399
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 418 F G M P AFN ND EII IP SFIK KGV SE EDA Y DY SAI GCVE TA VPGK W g YRCT G MSY IN FP K V L LITM NNG I D PAS GK RFA P SY G 497
Cdd:COG1882 400 T G S P QYE ND DLM IP MLLN KGV TL EDA R DY GIA GCVE PM VPGK Q - MQFF G AGR IN LA K A L EYAL NNG V D EKT GK QVG P ET G 478
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 498 HF T QMTS Y K E LK EA WD K T L R YL TRMS V IVE N A I DISLEREV P DILC SAL T D N CI G RGK H L K EGGA V Y DYISGLQV G IANL 577
Cdd:COG1882 479 DP T DFLT Y D E VM EA FK K Q L D YL ADLY V NAL N I I HYMHDKYA P EPFL SAL H D D CI E RGK D L N EGGA R Y NFGAIGIA G LSVV 558
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 578 S DSL A A L KKLVF EE K RL T TL E VWQ AL QSDYA G pr G EE I RQ M L I N e APKYGNDDDY A D SLVR E CYDVYVE EI A KY PNT R yg 657
Cdd:COG1882 559 A DSL S A I KKLVF DK K KV T MD E LLE AL AANFE G -- Y EE L RQ L L L N - APKYGNDDDY V D EIAV E LVETFMD EI R KY KTY R -- 633
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 658 rgpi GG IRYSGTSS I SA NV GQ G RG T L ATPDGR H AG T PLA E G C SP S H NM DK K GPT S VLKSV S KLP TDEIVG G V LLNQK VN P 737
Cdd:COG1882 634 ---- GG TYTLSILT I TS NV PY G KK T G ATPDGR K AG E PLA D G A SP M H GR DK N GPT A VLKSV A KLP YEKATD G I LLNQK FS P 709
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1080853602 738 QT L AK EE DKQK L IA LLRT F F N r L H G Y HIQ Y NVV S RETL I DAQKHPEK HR DL I VRVAGYSA F F NV LSK AT QDDIIARTEH 816
Cdd:COG1882 710 SA L GG EE GIEN L VS LLRT Y F D - L G G H HIQ F NVV D RETL L DAQKHPEK YP DL T VRVAGYSA Y F VE LSK EQ QDDIIARTEH 787
PFL2-3
TIGR01774 glycyl radical enzyme, PFL2/glycerol dehydratase family; This family previously was designated ...
25-818
0e+00
glycyl radical enzyme, PFL2/glycerol dehydratase family; This family previously was designated pyruvate formate-lyase, but it now appears that members include the B12-independent glycerol dehydratase. Therefore, the functional definition of the family is being broadened. This family includes the PflF and PflD proteins of E. coli, described as isoforms of pyruvate-formate lyase found in a limited number additional species. PFL catalyzes the reaction pyruvate + CoA -> acetyl-CoA + formate, which is a step in the fermentation of glucose.
Pssm-ID: 273798 [Multi-domain]
Cd Length: 786
Bit Score: 875.00
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 25 LTE R MYSYRDKVLDKKPFIDA ERA I L V TE AYQKHQEK P NVLK RA YM L QNI LE KMT I Y I D D ETM IVGN QASSDKD A P IFPE 104
Cdd:TIGR01774 2 CMD R IEKLKKALSKPVARLSV ERA R L Y TE SMKQTEGE P MIIR RA KA L AHV LE NIP I Q I L D SEL IVGN MLPNPRA A I IFPE 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 105 YTLEFVVN ELD LFEK R DGDV F YIT EE T K EQI R N - IAP F W ENNNLRAR A GVMLPE E VQVYME T GF F GME G k MNS G DA H L AV 183
Cdd:TIGR01774 82 GVGLWIIK ELD SLPN R PTNR F AVS EE D K RVL R E e IAP Y W QRKTIEDF A FGLMTD E MKILYT T SI F VLT G - EIA G IS H V AV 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 184 NY QK LL EE GL IGFEKKARKAKAD L DLTKPESID KY H FY DSIL I TI EAV KTYAE R F A I LA KKQ A KTAN - AK RR Q ELL D IA S 262
Cdd:TIGR01774 161 NY PY LL RR GL RWLLEESERRIRA L EESGVYEGE KY S FY QAAK I VL EAV INHIL R Y A K LA EEM A ASET g ES RR E ELL K IA E 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 263 IC ER V PYYPAK TF AE AVQ S VW FI Q C ILQ I ESN GH S L S Y GR F DQY M YP YV K A D LEA GR ETEDSIV E R L TN LWIKT IT I NKV 342
Cdd:TIGR01774 241 IC RK V AAEKPQ TF WQ AVQ L VW LV Q S ILQ Q ESN EQ S I S M GR I DQY L YP FY K K D IGE GR IDRELAF E I L AS LWIKT NE I VPA 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 343 RS QAHTFSS AG S P LY Q N VTIGG QTRHKE DAVN P LS F L V L KSVAQTH L P QPNL T VR YH A NLDK SF MNEAI E VMKL G F G M PA 422
Cdd:TIGR01774 321 RS SSLEQYF AG Q P TN Q A VTIGG CDIYGN DAVN E LS Y L M L EVTDRLR L R QPNL H VR IN A GSPE SF LKRLA E AIRS G C G N PA 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 423 FN NDE III P S F IKK GV SEE DA Y DY SAI GCVE T A VP G KW g Y RCTGMSY IN FP KV LLITM N N G I D PAS G KR F APSY ghf TQM 502
Cdd:TIGR01774 401 LF NDE AVV P A F KNA GV DDR DA L DY TTD GCVE I A PF G NS - Y TSSDAAL IN VA KV MEYAL N E G V D LQF G YE F GAKT --- EKP 476
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 503 TSYKE L K E AWDKTLRYLTRMS V IVE N AI D ISLEREV P DI L C S ALTDN C IGR G KHLKE GGA V Y DYISGLQ VGIANL S DSL A 582
Cdd:TIGR01774 477 KFLED L L E KLREQISHYVKLV V EGS N VL D YANAEVK P TP L L S LCVED C FEK G VDISR GGA R Y NFTGIQA VGIANL G DSL V 556
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 583 A L K KL VFE EKRLTTLEVWQ AL QSDYA G PRG EE I R QM LIN EA PKYGNDDD YA D SLVRECYDV Y V EE IAK Y P N T R ygrgpi G 662
Cdd:TIGR01774 557 A I K GA VFE QGAYSMDDLVE AL RKNFV G LTH EE K R HR LIN QS PKYGNDDD AV D KYTAMVLEW Y C EE VNR Y R N P R ------ G 630
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 663 G IRYS G TSSI SANV GQ G RG T L ATPDGR H AG T PLA E G C SPS HN MD KK GPT S V LK SVSKL PTDEIVG G V LLN Q K VN P Q TL AK 742
Cdd:TIGR01774 631 G KFAA G CYPM SANV PF G FF T S ATPDGR K AG E PLA P G V SPS TG MD RE GPT A V IN SVSKL SYENLPN G A LLN I K LS P A TL EE 710
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1080853602 743 E E DKQKLI AL LR TF F NR L HGY HIQ Y N V V SRE TL ID AQ KH PEK H R D L I VRVAGYSAFF NV LS KAT QDDII A RT E H A L 818
Cdd:TIGR01774 711 E G DKQKLI EA LR KS F ME L KVM HIQ F N I V KED TL RK AQ QE PEK Y R W L V VRVAGYSAFF VE LS RPV QDDII R RT S H R L 786
PFL-like
pfam02901 Pyruvate formate lyase-like; This family of enzymes includes pyruvate formate lyase, choline ...
25-679
0e+00
Pyruvate formate lyase-like; This family of enzymes includes pyruvate formate lyase, choline trimethylamine lyase, glycerol dehydratase, 4-hydroxyphenylacetate decarboxylase, and benzylsuccinate synthase.
Pssm-ID: 427048
Cd Length: 647
Bit Score: 727.12
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 25 LT ER MYSYRDKVL -- DKK P FIDA ERA I L V TE A Y QKHQ - EK P NVLK RA YM L QN IL EKMTI YI D D ETM IVG N Q ASSDKDAP I 101
Cdd:pfam02901 1 MW ER IDVLKENYT ly TGD P SLSW ERA R L L TE S Y KETE g VL P VDIR RA KA L KK IL SHLPG YI R D DEL IVG L Q TDKPRKRA I 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 102 F PE YTLEF V VN ELD LFEK R DG D V F Y I T EE T K EQI R N I A P F W ENNNLRARAGVMLPE E VQVYM E T G F F g MEGKMNS G DA H L 181
Cdd:pfam02901 81 Y PE GGIRW V ED ELD YLNT R PQ D G F E I S EE D K KIF R E I F P Y W KGKTHNEGVFDAYTP E MKAAR E S G I F - TGLPDAY G RG H I 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 182 AVN Y QKL L EE GL I G FEKKARKAK A D LD l T K PE S I D K YH FY DSIL I TIE AV KT YAER F A I LA KKQ A - KTANA KR RQ ELL D I 260
Cdd:pfam02901 160 IGD Y RRV L LY GL D G LIEEKEEKL A K LD - T D PE D I E K IE FY KAMI I SCD AV IE YAER Y A R LA EEL A e QETDP KR KA ELL E I 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 261 A S IC E RVP YY PA K TF A EA V Q SV WF IQCILQI E S NG HSL S Y GR F DQY M YPY VKA DLE A GR E TE DSIV E RLTNL WIK TITIN 340
Cdd:pfam02901 239 A E IC G RVP AR PA E TF Q EA I Q WF WF VYLAAVK E Q NG AAM S L GR L DQY L YPY YER DLE E GR L TE EEAQ E LIDCF WIK LREVR 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 341 KV R SQAHTFSS AG SPLY QN V TIGGQ T R HKE DAVN P LS F L V L KSVAQTH LP Q PNLTVR YHAN L DKS F MNE A I EV MKL G F G M 420
Cdd:pfam02901 319 FL R TPEYNKLF AG YDPF QN L TIGGQ G R DGR DAVN K LS Y L I L EALDNLP LP E PNLTVR WSKK L PEE F LKK A A EV SRK G T G S 398
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 421 P AFN ND EII IP SFIKK GVS E EDA Y DY SAI GCVE TAV PGK - WGYRC tgm SY IN FP K V L LITM N N G I D PAS GK RFA P SY G HF 499
Cdd:pfam02901 399 P QYE ND DVM IP ALLNR GVS L EDA R DY GIA GCVE PMK PGK e MQFFG --- AR IN LA K A L EYAL N G G R D ELT GK QVG P KT G PV 475
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 500 T QMT S YK E LK EA WD K T L R YL TRMS V IVE N A I DISLEREV P DILC SAL T D N CI G RGK HLKE GGA V Y DYISGLQV G I AN LS D 579
Cdd:pfam02901 476 T EFL S FE E VM EA FK K Q L D YL ADLY V NAL N I I HYMHDKYA P EPFL SAL H D D CI E RGK DVGI GGA R Y NFSGPQGA G L AN VA D 555
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 580 SL A A L KKLVF EE K RL T TL E VWQ AL QS D YA G P rg EE I RQ M L I N E APKYGNDDD YA D SLVR E CYDVYVE E IA KY P N T R ygrg 659
Cdd:pfam02901 556 SL S A I KKLVF DD K VY T LR E LED AL AA D FE G E -- EE L RQ D L L N D APKYGNDDD RV D DIAV E VVETFMD E VR KY K N Y R ---- 629
650 660
....*....|....*....|
gi 1080853602 660 pi GG IRYSGTSS I SA NV GQ G 679
Cdd:pfam02901 630 -- GG KFTPSLLT I TS NV PY G 647
pflD
PRK09983 putative formate acetyltransferase 2; Provisional
25-818
0e+00
putative formate acetyltransferase 2; Provisional
Pssm-ID: 182181 [Multi-domain]
Cd Length: 765
Bit Score: 565.21
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 25 L T E R MYSYRDKVLDKKPF I DA ERA I L V T EAYQKHQEK P NV L K RA YMLQN ILE KMT I Y I D DE TM I V GN QASSDKDAPIF PE 104
Cdd:PRK09983 1 M T N R ISRLKTALFANTRE I SL ERA L L Y T ASHRQTEGE P VI L R RA KATAY ILE HVE I S I R DE EL I A GN RTVKPRAGIMS PE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 105 YTLEFVVN ELD L F EK R DG D V F Y I T EE T K EQI R N - IA P F WE NNNLRARAGVMLPE EV QVYME T GF F GME g KMNS G DA H LAV 183
Cdd:PRK09983 81 MDPYWLLK ELD Q F PT R PQ D R F A I S EE D K RIY R E e LF P Y WE KRSMKDFINGQMTD EV KAATS T QI F SIN - QTDK G QG H III 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 184 N Y QK LL EE GL IGFEKKARKAKAD ldlt K PE S idky HFY DSI L ITI EA VKTYAE R F A I LA KKQ A KT - AN A K RR Q ELL D IA S 262
Cdd:PRK09983 160 D Y PR LL NH GL GELVAQMQQHCQQ ---- Q PE N ---- HFY QAA L LLL EA SQKHIL R Y A E LA ETM A AN c TD A Q RR E ELL T IA E 231
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 263 I CERVPYYPAK TF AE A V Q SV W FIQC ILQ I ESN GH SLS Y GRFDQYM Y P YVK A D L EA G r E TEDSIV E R L TN LW I K TIT I NKV 342
Cdd:PRK09983 232 I SRHNAQHKPQ TF WQ A C Q LF W YMNI ILQ Y ESN AS SLS L GRFDQYM L P FYQ A S L TQ G - E DPAFLK E L L ES LW V K CND I VLL 310
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 343 RS QAHTFSS AG S P LYQNVTI GG Q T RHKED AVN P LSFL V L KSVAQTH LPQPNL T VR YH A NL D KS F MNEAI E VMK LG F G M P A 422
Cdd:PRK09983 311 RS TSSARYF AG F P TGYTALL GG L T ENGRS AVN V LSFL C L DAYQSVQ LPQPNL G VR TN A LI D TP F LMKTA E TIR LG T G I P Q 390
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 423 FN NDE III P S F IKK GVS E EDA Y DYS AI GCVE TAV PG K w G Y RCTGMSYI N FP KV LL I TM -- N N G IDP asgkrfapsyghft 500
Cdd:PRK09983 391 IF NDE VVV P A F LNR GVS L EDA R DYS VV GCVE LSI PG R - T Y GLHDIAMF N LL KV ME I CL he N E G NAA -------------- 455
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 501 qm TS Y KE L K E AWDKTLRYLTRMS V IVE N AI DI SLEREV P DI L C S ALTDN C IGR G KHLKE GGA V Y DY i SG L Q - V GIANLSD 579
Cdd:PRK09983 456 -- LT Y EG L L E QIRAKISHYITLM V EGS N IC DI GHRDWA P VP L L S SFISD C LEK G RDITD GGA R Y NF - SG V Q g I GIANLSD 532
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 580 SL A ALK KL VF EEK RL TTL E VWQA L QSDY A G P R GE EI R QM LIN EAP KYGND D D YA D SLVR E CYDV Y VE E IA KY P N T R ygrg 659
Cdd:PRK09983 533 SL H ALK GM VF DQQ RL SFD E LLSV L KANF A T P E GE KV R AR LIN RFE KYGND I D EV D NISA E LLRH Y CK E VE KY Q N P R ---- 608
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 660 pi GG IRYS G TSSI SA N V GQ G RGTL ATPDGR H AG TP LA E - G C SP SHNM D KK GPT S VLKSVSKL PTDEIVG G V LLN Q K VN P Q 738
Cdd:PRK09983 609 -- GG YFTP G SYTV SA H V PL G SVVG ATPDGR F AG EQ LA D g G L SP MLGQ D AQ GPT A VLKSVSKL DNTLLSN G T LLN V K FT P A 686
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 739 TL AK E EDKQ KL IAL LR T f F NR L HGY HIQ Y NVV SRE TL ID AQ KH P EKHRD L I VRVAGYSAFF NV LSK AT QDDII A RT E H A L 818
Cdd:PRK09983 687 TL EG E AGLR KL ADF LR A - F TQ L KLQ HIQ F NVV NAD TL RE AQ QR P QDYAG L V VRVAGYSAFF VE LSK EI QDDII R RT A H Q L 765
choline_CutC
TIGR04394 choline trimethylamine-lyase; Members of this family, homologs to pyruvate formate-lyases and ...
25-814
1.07e-175
choline trimethylamine-lyase; Members of this family, homologs to pyruvate formate-lyases and benzylsuccinate synthases, are glycine radical enzymes that appear to act as choline TMA-lyase, that is, to perform a C-N bond cleavage turning choline into trimethylamine (TMA) plus acetaldehyde. The gene symbol is cutC, for choline utilization. The activase, CutD, is a radical SAM enzyme. [Energy metabolism, Amino acids and amines]
Pssm-ID: 275187 [Multi-domain]
Cd Length: 789
Bit Score: 525.52
E-value: 1.07e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 25 L TER MYSYRDKV L DKK P F I DAE RA ILV TE AYQKHQEK P NV L K RA YMLQNIL E KMTIY I D D ETM IVG NQASSDKDAPIF P E 104
Cdd:TIGR04394 1 P TER LVRLKENY L KQV P S I TIY RA RAI TE IAKENPGM P KI L L RA KAFRKCC E TAPLV I Q D DEL IVG APCGAPRAGAFS P D 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 105 YTLEFVVN ELD LFEK R DG D V FYI T EE T K EQI R N - I A PFWE NNN L raragvmlp E E V -- QV Y M E T G FFGME G KMNSG D - AH 180
Cdd:TIGR04394 81 IAWRWLRD ELD TIGT R PQ D P FYI S EE D K KIM R E e I F PFWE GKS L --------- D E Y ce DQ Y R E A G VWELS G ESFVS D c SY 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 181 L AVN -------- Y QKL L - EE G LIGFEKK A RKAK A D L DLTK PE S IDK YH FY D S ILI T I E A V KT YA E R FAIL A KKQ A - K TAN 250
Cdd:TIGR04394 152 H AVN gggdsnpg Y DVI L m KK G MLDIQAE A KEHL A E L SYEN PE D IDK IY FY K S VID T T E G V MI YA K R LSEY A AEL A a K EQD 231
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 251 A KR RQ EL LD IA SICE RVP YYPAK TF A EA V QSVW FIQCI L QI E S N GHSL S Y GR F DQYMYP YV KAD L EAGR E TE DSIV E RLT 330
Cdd:TIGR04394 232 P KR KA EL EK IA EVNA RVP AHKPR TF W EA I QSVW TVESL L VV E E N QTGM S I GR V DQYMYP FY KAD I EAGR M TE YEAF E LAG 311
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 331 NLW IK TITINKVR S QAHTFSS AG SPLYQ N VTI GG Q TR HKE DA V N P L SF L VLKS V AQTHLP QP N L TV R Y H ANLDKSFMNEA 410
Cdd:TIGR04394 312 CML IK MSEMMWLT S EGGSKFF AG YQPFV N MCV GG V TR EGG DA T N D L TY L LMDA V RHVKVY QP S L AC R I H NKSPQKYLKKI 391
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 411 IE V MKL G F G M PA FNN D EII I PSFIK KGVS E EDA Y DY SAI GCVE tav P G K W G -- Y RC T GMS Y INF P KVLLITM N N G IDPAS 488
Cdd:TIGR04394 392 VD V VRA G M G F PA CHF D DAH I KMMLA KGVS I EDA R DY CLM GCVE --- P Q K S G rl Y QW T STA Y TQW P ICIELVL N H G VPLWY 468
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 489 GK RFA P SY G HFT Q MTS Y KELKE A WDKTLR Y L T RM S V i V ENA I DISLE R EV - P DI L C S ALTDN C IGR GK HLKE GGA V Y DYI 567
Cdd:TIGR04394 469 GK QVC P DT G DLS Q FDT Y EKFDA A VKEQIK Y I T KW S A - V ATV I SQRVH R DL a P KP L M S LMYEG C MEK GK DVSA GGA M Y NFG 547
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 568 S G L - QV G I A NLS DS L AA L KKLV FEE K RL T TLEVWQ AL QSDYA G P rg E E IR QMLIN e APKYGNDDDYAD SLVRECYDVYVE 646
Cdd:TIGR04394 548 P G V v WS G L A TYA DS M AA I KKLV YDD K KY T LEQLNE AL KANFE G Y -- E Q IR ADCLD - APKYGNDDDYAD LIAADLVNFTER 624
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 647 E IA KY p N T R Y grgpig GIRYS GT S SIS A N VGQ G RG T L A TPD GR H A G TPL AE G C SP SHNM D K KGPT SVL KSVSK LPT D EIV 726
Cdd:TIGR04394 625 E HR KY - K T L Y ------ SHLSH GT L SIS N N TPF G QL T G A SAN GR L A W TPL SD G I SP TQGA D F KGPT AII KSVSK MAN D SMN 697
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 727 G G VLL N Q K VNPQT L AKE E DKQK LI A LLRT f FNR L HGYHI Q Y N VVSR ETL I DAQ K HPEK H RDL I VRVAGYSAFF NV L S K AT 806
Cdd:TIGR04394 698 I G MVH N F K LMSGL L DTP E GENG LI T LLRT - ASI L GNGEM Q F N YLDN ETL L DAQ Q HPEK Y RDL V VRVAGYSAFF VE L C K DV 776
....*...
gi 1080853602 807 QD D II A RT 814
Cdd:TIGR04394 777 QD E II S RT 784
PFL1
cd01678 Pyruvate formate lyase 1; Pyruvate formate lyase catalyzes a key step in anaerobic glycolysis, ...
271-816
4.29e-71
Pyruvate formate lyase 1; Pyruvate formate lyase catalyzes a key step in anaerobic glycolysis, the conversion of pyruvate and CoenzymeA to formate and acetylCoA. The PFL mechanism involves an unusual radical cleavage of pyruvate in which two cysteines and one glycine form radicals that are required for catalysis. PFL has a ten-stranded alpha/beta barrel domain that is structurally similar to those of all three ribonucleotide reductase (RNR) classes as well as benzylsuccinate synthase and B12-independent glycerol dehydratase.
Pssm-ID: 153087 [Multi-domain]
Cd Length: 738
Bit Score: 248.43
E-value: 4.29e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 271 PA KTFA EA V Q SVW F IQCILQI E S NG HSL S Y GR FDQYMYP Y VKA DL E AG RE TE DSIV E RLTNLWI K TITINKV R SQAHTFS 350
Cdd:cd01678 234 PA TNAQ EA I Q WTY F GYLAAIK E Q NG AAM S L GR VSTFLDI Y IER DL K AG TI TE AEAQ E LIDQFIM K LRMVRFL R TPEYNEL 313
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 351 SA G S P LYQNVT IGG QT --- R HK eda V NPL SF LV L KSV aq TH L --- P Q PNLTV RYHAN L DKS F MNEAIE V MKLGFGM p AFN 424
Cdd:cd01678 314 FS G D P TWVTES IGG MG ndg R SL --- V TKT SF RF L NTL -- YN L gpa P E PNLTV LWSEK L PEN F KRFCAK V SIDTSSI - QYE 387
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 425 ND EIII P SF ikkgvseed AY D YSA I G C - V ETAVP GK ---- W G Y R C tgmsyi N FP K V LL ITM N N G I D PAS G KRFA P SYGHF 499
Cdd:cd01678 388 ND DLMR P DW --------- GG D DYG I A C c V SAMRI GK qmqf F G A R A ------ N LA K A LL YAI N G G R D EKT G DQVG P DIEPI 452
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 500 T QMT - S Y K E LK E AW DK TLRY L TRMS V IVE N A I DISLEREVPDI L CS AL T D NCIG R G khlkeggavydyisg LQV GIA N LS 578
Cdd:cd01678 453 T SDY l D Y D E VM E NY DK SMDW L ADTY V NAL N I I HYMHDKYAYEA L QM AL H D TDVR R T --------------- MAF GIA G LS 517
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 579 --- DSL A A L K ---- K LVFE E KR L TT levwqalqs D Y agprge EI R qmli NEA P K YGNDDD Y AD SLVRECYDVYVEEIA K Y 651
Cdd:cd01678 518 vaa DSL S A I K yakv K PIRD E DG L AV --------- D F ------ EI E ---- GDF P R YGNDDD R AD DIAVWVVKTFMNKLR K H 578
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 652 PNT R YGRG piggirysg T S S --- I SA NV GQ G RG T LA TPDGR H AG T P L A E G CS P S H NM DKKG PTSV L K SV S KLP TDEIVG G 728
Cdd:cd01678 579 KTY R NAEP --------- T Q S vlt I TS NV VY G KK T GN TPDGR R AG E P F A P G AN P M H GR DKKG ALAS L A SV A KLP YRDAND G 649
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 729 VLLNQKVN P QT L A K EEDKQK -- L IAL L RTF F NR l H G Y H IQY NV VS RETL I DA QK HPEK HRD L IV RV A GY SAF F NV L SKAT 806
Cdd:cd01678 650 ISNTFSIV P NA L G K TDEERI dn L VGI L DGY F TK - G G H H LNV NV LN RETL L DA ME HPEK YPQ L TI RV S GY AVN F VK L TREQ 728
570
....*....|
gi 1080853602 807 Q D D I I A RT E H 816
Cdd:cd01678 729 Q L D V I S RT F H 738
Gly_radical
pfam01228 Glycine radical;
695-800
1.96e-43
Glycine radical;
Pssm-ID: 426140 [Multi-domain]
Cd Length: 106
Bit Score: 152.32
E-value: 1.96e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 695 L A E G C SPSH NM D KK GPT S VL K SV S K LPTDEIVG G VL LNQK VN P QT L AK -- EE DKQK L IA L LR T F F NR lh G Y H I Q Y NVV S R 772
Cdd:pfam01228 1 V A P G I SPSH GA D FE GPT A VL N SV G K IDYEVELD G IS LNQK FL P AV L GY yd EE GYAN L NT L ID T Y F EG -- G H H L Q F NVV D R 78
90 100
....*....|....*....|....*...
gi 1080853602 773 ETL I DAQKHPEK HR DL I VRV A GYSA F F N 800
Cdd:pfam01228 79 ETL P DAQKHPEK YP DL T VRV S GYSA N F V 106
PRK11127
PRK11127 autonomous glycyl radical cofactor GrcA; Provisional
762-816
1.26e-17
autonomous glycyl radical cofactor GrcA; Provisional
Pssm-ID: 182983 [Multi-domain]
Cd Length: 127
Bit Score: 79.89
E-value: 1.26e-17
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1080853602 762 G Y H IQY NV VS RETL I DA Q KHPEK HRD L IV RV A GY SAF FN V L SKAT Q D D I IART EH 816
Cdd:PRK11127 70 G Q H LNV NV LR RETL E DA V KHPEK YPQ L TI RV S GY AVR FN S L TPEQ Q R D V IART FT 124
RNR_PFL
cd00576 Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ...
271-769
4.03e-11
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
Pssm-ID: 153083 [Multi-domain]
Cd Length: 401
Bit Score: 65.63
E-value: 4.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 271 P AK TFA EA V Q SVWF I QCILQIES NG HSL S YG R FDQYMY PY VKA D LEA G RE TE DSI VE RLTNLWIKTITI nkvrsqaht FS 350
Cdd:cd00576 44 T AK SIN EA I Q KTYQ I IALAASNQ NG GGV S FA R ASSILS PY GSR D YAK G SG TE TDA VE AADAFNLALKEV --------- GQ 114
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 351 SA G SPLYQNVT IGG QTRH K E D AVN p LS FL V L K --- SVAQTH L PQ PNL T VR yhanldksfmneaievmk LGFGM P AFNNDE 427
Cdd:cd00576 115 GN G RTGAATGF IGG VHKG K G D KIS - QE FL N L A lan GGEGIP L NF PNL S VR ------------------ VSSDK P GILVKA 175
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 428 IIIPSF I KKGVSEE - DAYDYSAIG C VETAVP gkwgyrctgmsyinfpkv L LIT M NNG I d PA S GKRF apsyghftqmts YK 506
Cdd:cd00576 176 VELKQL I AEEARKT g SPGIFNDEL C NLVSLN ------------------ L ARI M EKA I - NG S MDVV ------------ LE 224
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 507 EL K E AWDKTL R Y L trmsvive NAIDI S LEREV P D I lcsaltdncigrgkhl KE GG AVYD y IS GL Q - V G I A N L SDS L aalk 585
Cdd:cd00576 225 EL E E LAFLAV R A L -------- DCVID S HDERI P T I ---------------- EL GG DERR - TV GL G i A G V A D L LIK L ---- 275
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 586 klvfeekrlttlevwqalqsdyagprgeeirqmlin EAP K Y G nd D DY AD S L VR E CY D VYVEEIA K YP N T R y G RGPIG G IR 665
Cdd:cd00576 276 ------------------------------------ GLE K V G -- D PE AD D L AA E LV D QLKKHLV K AT N E R - G FNFLL G LS 316
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080853602 666 Y S GTS S isanvgqgrgtlatpdgrh A G T P LAE G C SPS HNM ------ DKK GP TSV L K SV SK L PT d EIVG G VLLNQKVNPQT 739
Cdd:cd00576 317 P S ESN S ------------------- S G A P ATN G V SPS RG* iaivln GDI GP EES L A SV AI L QF - YADN G ISDTITIPDSA 376
490 500 510
....*....|....*....|....*....|
gi 1080853602 740 LAKEE dkqk L I A LLRTFF n RLHGY H IQY N V 769
Cdd:cd00576 377 TNLDQ ---- L L A VIDGAA - AIKTT H VRV N P 401
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
