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Conserved domains on  [gi|1080605215|gb|OFN81649|]
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choline-binding protein D [Streptococcus sp. HMSC061D10]

Protein Classification

N-acetylmuramoyl-L-alanine amidase family protein( domain architecture ID 11474208)

N-acetylmuramoyl-L-alanine amidase family protein such as N-acetylmuramoyl-L-alanine amidase (or lytic amidase), which hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pneumo_PspA super family cl41532
pneumococcal surface protein A; The pneumococcal surface protein proteins, found in ...
 233-369 1.06e-49

pneumococcal surface protein A; The pneumococcal surface protein proteins, found in Streptococcus pneumoniae, are repetitive, with patterns of localized high sequence identity across pairs of proteins given different specific names that recombination may be presumed. This protein, PspA, has an N-terminal region that lacks a cross-wall-targeting YSIRK type extended signal peptide, in contrast to the closely related choline-binding protein CbpA which has a similar C-terminus but a YSIRK-containing region at the N-terminus.


The actual alignment was detected with superfamily member NF033930:

Pssm-ID: 468251 [Multi-domain]  Cd Length: 660  Bit Score: 177.03  E-value: 1.06e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215 233 WISYisrsgNRRYIPLTKTGSSKNGWAKEGTSWYYYE-NGQIAVGWKKINGNWYHLQADGRMTTGWLKDGSNWYYLKSSG 311
Cdd:NF033930  525 WLQY-----NGSWYYLNANGAMATGWLKYNGSWYYLNaNGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYLNANG 599

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1080605215 312 EMQTGWLKDKGIWYYLESSGAMKTNQWFQVSGKHYYVNASGELAVNTTIDGFQVDGDG 369
Cdd:NF033930  600 SMATGWVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNGLGALAVNTTVDGYTVNANG 657
COG5263 COG5263
Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism];
11-372 5.29e-30

Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism];


:

Pssm-ID: 444077 [Multi-domain]  Cd Length: 486  Bit Score: 120.36  E-value: 5.29e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215  11 GTFLRKTAVGSASLLLAGVFLFGGGTVHANQANNGSLARGDDYPYYYKNGSQKIDKWRMYSGQCTSFAAFRLSSVNGFEL 90
Cdd:COG5263   137 GGKTKKGDTNSANTGYLGDDLGGGTADKGGSAGYGAGKDGATAAAKELVGSAADTYYGGASTYLTGDAGAYGALGLAAGS 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215  91 PAAYGNANQWGYRAQKEGYRVDQQPAIGAIAWSTRGQYGHVAWVSNVIGDMIEIEEYNYDYTETYHSRIVKASSMTGFIH 170
Cdd:COG5263   217 GAGAKKTGSTAGASGTAYGDSGGTAGSGLSSLGGSSNALESGGENNQSLAGNGTSYDDAGAAGVDGTGTTGTVGWVDGKW 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215 171 FKDVGNASVGHHQSllaFSGTHHFTEKSAIMdqpsltstVIDYYEAGMSVHYdqtFEKEGYKWISYISRSGNRRYipLTK 250
Cdd:COG5263   297 YYFDAGKMVTGWQT---INGKWYYFDSDGAM--------ATGWQKINGKWYY---FDEDGAMATGWVTDDGKWYY--LGS 360

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215 251 TGSSKNGWAKEGTSWYYY-ENGQIAVGWKKINGNWYHLQADGRMTTGWLKDGSNWYYLKSSGEMQTGWLKDKGIWYYLES 329
Cdd:COG5263   361 DGAMATGWQKIDGKWYYFdSNGAMATGWVKVDGKWYYFDSSGAMATGWLKIDGKWYYFDSDGAMATGWQKIGGKWYYFDS 440

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1080605215 330 SGAMKTNqWFQVSGKHYYVNASGELAVNT-TIDG--FQVDGDGVRV 372
Cdd:COG5263   441 NGAMATG-WVKVDGKWYYFDSDGAMATGWqTIDGktYYFDSNGAWV 485
 
Name Accession Description Interval E-value
pneumo_PspA NF033930
pneumococcal surface protein A; The pneumococcal surface protein proteins, found in ...
 233-369 1.06e-49

pneumococcal surface protein A; The pneumococcal surface protein proteins, found in Streptococcus pneumoniae, are repetitive, with patterns of localized high sequence identity across pairs of proteins given different specific names that recombination may be presumed. This protein, PspA, has an N-terminal region that lacks a cross-wall-targeting YSIRK type extended signal peptide, in contrast to the closely related choline-binding protein CbpA which has a similar C-terminus but a YSIRK-containing region at the N-terminus.


Pssm-ID: 468251 [Multi-domain]  Cd Length: 660  Bit Score: 177.03  E-value: 1.06e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215 233 WISYisrsgNRRYIPLTKTGSSKNGWAKEGTSWYYYE-NGQIAVGWKKINGNWYHLQADGRMTTGWLKDGSNWYYLKSSG 311
Cdd:NF033930  525 WLQY-----NGSWYYLNANGAMATGWLKYNGSWYYLNaNGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYLNANG 599

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1080605215 312 EMQTGWLKDKGIWYYLESSGAMKTNQWFQVSGKHYYVNASGELAVNTTIDGFQVDGDG 369
Cdd:NF033930  600 SMATGWVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNGLGALAVNTTVDGYTVNANG 657
PspC_relate_1 NF033840
PspC-related protein choline-binding protein 1; Members of this family share C-terminal ...
 252-369 5.29e-49

PspC-related protein choline-binding protein 1; Members of this family share C-terminal homology to the choline-binding form of the pneumococcal surface antigen PspC, but not to its allelic LPXTG-anchored forms because they lack the choline-binding repeat region. Members of this family should not be confused with PspC itself, whose identity and function reflect regions N-terminal to the choline-binding region. See Iannelli, et al. (PMID: 11891047) for information about the different allelic forms of PspC.


Pssm-ID: 411409 [Multi-domain]  Cd Length: 648  Bit Score: 174.89  E-value: 5.29e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215 252 GSSKNGWAKEGTSWYYY-ENGQIAVGWKKINGNWYHLQADGRMTTGWLKDGSNWYYLKSSGEMQTGWLKDKGIWYYLESS 330
Cdd:NF033840  526 GSMATGWVQVNGSWYYLnSNGSMATGWVQVNGSWYYLNSNGSMATGWVQVDGSWYYLNDNGSMETGWLQNNGSWYYLNSN 605

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1080605215 331 GAMKTNQWFQVSGKHYYVNASGELAVNTTIDGFQVDGDG 369
Cdd:NF033840  606 GSMKANQWFQVGSKWYYVNASGELAVNTSIDGYRVNDNG 644
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 248-369 4.72e-47

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 170.19  E-value: 4.72e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215 248 LTKTGSSKNGWAKEGTSWYYYE-NGQIAVGWKKINGNWYHLQADGRMTTGWLKDGSNWYYLKSSGEMQTGWLKDKGIWYY 326
Cdd:NF033838  558 LNANGAMATGWLQYNGSWYYLNaNGDMATGWLQYNGSWYYLNANGDMATGWLQYNGSWYYLNANGSMATGWVKDGDTWYY 637

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1080605215 327 LESSGAMKTNQWFQVSGKHYYVNASGELAVNTTIDGFQVDGDG 369
Cdd:NF033838  638 LEASGAMKASQWFKVSDKWYYVNGSGALAVNTTVDGYGVNANG 680
pneumo_PspA NF033930
pneumococcal surface protein A; The pneumococcal surface protein proteins, found in ...
 247-355 1.78e-34

pneumococcal surface protein A; The pneumococcal surface protein proteins, found in Streptococcus pneumoniae, are repetitive, with patterns of localized high sequence identity across pairs of proteins given different specific names that recombination may be presumed. This protein, PspA, has an N-terminal region that lacks a cross-wall-targeting YSIRK type extended signal peptide, in contrast to the closely related choline-binding protein CbpA which has a similar C-terminus but a YSIRK-containing region at the N-terminus.


Pssm-ID: 468251 [Multi-domain]  Cd Length: 660  Bit Score: 134.27  E-value: 1.78e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215 247 PLTKTGSSKNGWAKEGTSWYYYE-NGQIAVGWKKINGNWYHLQADGRMTTGWLKDGSNWYYLKSSGEMQTGWLKDKGIWY 325
Cdd:NF033930  434 PEQPAPAPKTGWKQENGMWYFYNtDGSMATGWLQNNGSWYYLNSNGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWY 513

                          90       100       110
                  ....*....|....*....|....*....|
gi 1080605215 326 YLESSGAMKTNqWFQVSGKHYYVNASGELA 355
Cdd:NF033930  514 YLNANGAMATG-WLQYNGSWYYLNANGAMA 542
COG5263 COG5263
Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism];
11-372 5.29e-30

Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism];


Pssm-ID: 444077 [Multi-domain]  Cd Length: 486  Bit Score: 120.36  E-value: 5.29e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215  11 GTFLRKTAVGSASLLLAGVFLFGGGTVHANQANNGSLARGDDYPYYYKNGSQKIDKWRMYSGQCTSFAAFRLSSVNGFEL 90
Cdd:COG5263   137 GGKTKKGDTNSANTGYLGDDLGGGTADKGGSAGYGAGKDGATAAAKELVGSAADTYYGGASTYLTGDAGAYGALGLAAGS 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215  91 PAAYGNANQWGYRAQKEGYRVDQQPAIGAIAWSTRGQYGHVAWVSNVIGDMIEIEEYNYDYTETYHSRIVKASSMTGFIH 170
Cdd:COG5263   217 GAGAKKTGSTAGASGTAYGDSGGTAGSGLSSLGGSSNALESGGENNQSLAGNGTSYDDAGAAGVDGTGTTGTVGWVDGKW 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215 171 FKDVGNASVGHHQSllaFSGTHHFTEKSAIMdqpsltstVIDYYEAGMSVHYdqtFEKEGYKWISYISRSGNRRYipLTK 250
Cdd:COG5263   297 YYFDAGKMVTGWQT---INGKWYYFDSDGAM--------ATGWQKINGKWYY---FDEDGAMATGWVTDDGKWYY--LGS 360

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215 251 TGSSKNGWAKEGTSWYYY-ENGQIAVGWKKINGNWYHLQADGRMTTGWLKDGSNWYYLKSSGEMQTGWLKDKGIWYYLES 329
Cdd:COG5263   361 DGAMATGWQKIDGKWYYFdSNGAMATGWVKVDGKWYYFDSSGAMATGWLKIDGKWYYFDSDGAMATGWQKIGGKWYYFDS 440

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1080605215 330 SGAMKTNqWFQVSGKHYYVNASGELAVNT-TIDG--FQVDGDGVRV 372
Cdd:COG5263   441 NGAMATG-WVKVDGKWYYFDSDGAMATGWqTIDGktYYFDSNGAWV 485
COG5263 COG5263
Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism];
248-335 2.83e-20

Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism];


Pssm-ID: 444077 [Multi-domain]  Cd Length: 486  Bit Score: 92.24  E-value: 2.83e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215 248 LTKTGSSKNGWAKEGTSWYYY-ENGQIAVGWKKINGNWYHLQADGRMTTGWLKDGSNWYYLKSSGEMQTGWLKDKGIWYY 326
Cdd:COG5263   398 FDSSGAMATGWLKIDGKWYYFdSDGAMATGWQKIGGKWYYFDSNGAMATGWVKVDGKWYYFDSDGAMATGWQTIDGKTYY 477


                  ....*....
gi 1080605215 327 LESSGAMKT 335
Cdd:COG5263   478 FDSNGAWVG 486
SH3_5 pfam08460
Bacterial SH3 domain;
189-248 1.11e-13

Bacterial SH3 domain;


Pssm-ID: 430010 [Multi-domain]  Cd Length: 68  Bit Score: 65.48  E-value: 1.11e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1080605215 189 SGTHHFTEKSAIMD---QPSLTSTVIDYYEAGMSVHYDQTFEKEGYKWISYISRSGNRRYIPL 248
Cdd:pfam08460   6 QGTFTIGGKTGIVLrknEPSLSAPVQFVLYKGDKVFYDQVLLADGYVWISYTSYNGVRRYLPV 68
Choline_bind_3 pfam19127
Choline-binding repeat; Pair of presumed choline-binding repeats often found adjacent to ...
 274-338 5.43e-08

Choline-binding repeat; Pair of presumed choline-binding repeats often found adjacent to pfam01473.


Pssm-ID: 465978 [Multi-domain]  Cd Length: 47  Bit Score: 48.69  E-value: 5.43e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1080605215 274 AVGWKKINGNWYHLQADGRMTTGWLK-DGSNWYylkssgemqtgwlkdkgiwYYLESSGAMKTNQW 338
Cdd:pfam19127   1 VTGWQTINGQTLYFDSDGKQVKGWVVtIDGKWY-------------------YFDADSGEMVTNRF 47
PRK08581 PRK08581
amidase domain-containing protein;
72-148 1.15e-05

amidase domain-containing protein;


Pssm-ID: 236304 [Multi-domain]  Cd Length: 619  Bit Score: 47.09  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215  72 GQCTSFAAFRL----SSVNGFelpaaYGNANQWGYRAQKEGYRVDQQPAIGAIAWSTRGQ------YGHVAWVSNVIGD- 140
Cdd:PRK08581  511 GQCTWYVYNRMkqfgTSISGD-----LGDAHNWNNRAQARGYQVSHTPKRHAAVVFEAGQagadqhYGHVAFVEKVNSDg 585


                  ....*...
gi 1080605215 141 MIEIEEYN 148
Cdd:PRK08581  586 SIVISESN 593
glucan_65_rpt TIGR04035
glucan-binding repeat; This model describes a region of about 63 amino acids that is composed ...
 266-343 7.35e-04

glucan-binding repeat; This model describes a region of about 63 amino acids that is composed of three repeats of a more broadly distributed family of shorter repeats modeled by pfam01473. While the shorter repeats are often associated with choline binding (and therefore with cell wall binding), the longer repeat described here represents a subgroup of repeat sequences associated with glucan binding, as found in a number glycosylhydrolases. Shah, et al. describe a repeat consensus, WYYFDANGKAVTGAQTINGQTLYFDQDGKQVKG, that corresponds to half of the repeat as modeled here and one and a half copies of the repeat as modeled by pfam01473.


Pssm-ID: 274933 [Multi-domain]  Cd Length: 62  Bit Score: 37.50  E-value: 7.35e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1080605215 266 YYYENGQIAVGWKKINGNWYHLQADGRMTTG-WLKDGSNWYylkssgemqtgwlkdkgiwYYLESSGAMKTNQWFQVSG 343
Cdd:TIGR04035   2 YFDADGKAVTGAQTIDGVTYYFDENGKQVKGdFVTNGGGTY-------------------YYDKDSGALVTNRFVTIKD 61
 
Name Accession Description Interval E-value
pneumo_PspA NF033930
pneumococcal surface protein A; The pneumococcal surface protein proteins, found in ...
 233-369 1.06e-49

pneumococcal surface protein A; The pneumococcal surface protein proteins, found in Streptococcus pneumoniae, are repetitive, with patterns of localized high sequence identity across pairs of proteins given different specific names that recombination may be presumed. This protein, PspA, has an N-terminal region that lacks a cross-wall-targeting YSIRK type extended signal peptide, in contrast to the closely related choline-binding protein CbpA which has a similar C-terminus but a YSIRK-containing region at the N-terminus.


Pssm-ID: 468251 [Multi-domain]  Cd Length: 660  Bit Score: 177.03  E-value: 1.06e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215 233 WISYisrsgNRRYIPLTKTGSSKNGWAKEGTSWYYYE-NGQIAVGWKKINGNWYHLQADGRMTTGWLKDGSNWYYLKSSG 311
Cdd:NF033930  525 WLQY-----NGSWYYLNANGAMATGWLKYNGSWYYLNaNGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYLNANG 599

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1080605215 312 EMQTGWLKDKGIWYYLESSGAMKTNQWFQVSGKHYYVNASGELAVNTTIDGFQVDGDG 369
Cdd:NF033930  600 SMATGWVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNGLGALAVNTTVDGYTVNANG 657
PspC_relate_1 NF033840
PspC-related protein choline-binding protein 1; Members of this family share C-terminal ...
 252-369 5.29e-49

PspC-related protein choline-binding protein 1; Members of this family share C-terminal homology to the choline-binding form of the pneumococcal surface antigen PspC, but not to its allelic LPXTG-anchored forms because they lack the choline-binding repeat region. Members of this family should not be confused with PspC itself, whose identity and function reflect regions N-terminal to the choline-binding region. See Iannelli, et al. (PMID: 11891047) for information about the different allelic forms of PspC.


Pssm-ID: 411409 [Multi-domain]  Cd Length: 648  Bit Score: 174.89  E-value: 5.29e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215 252 GSSKNGWAKEGTSWYYY-ENGQIAVGWKKINGNWYHLQADGRMTTGWLKDGSNWYYLKSSGEMQTGWLKDKGIWYYLESS 330
Cdd:NF033840  526 GSMATGWVQVNGSWYYLnSNGSMATGWVQVNGSWYYLNSNGSMATGWVQVDGSWYYLNDNGSMETGWLQNNGSWYYLNSN 605

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1080605215 331 GAMKTNQWFQVSGKHYYVNASGELAVNTTIDGFQVDGDG 369
Cdd:NF033840  606 GSMKANQWFQVGSKWYYVNASGELAVNTSIDGYRVNDNG 644
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 248-369 4.72e-47

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 170.19  E-value: 4.72e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215 248 LTKTGSSKNGWAKEGTSWYYYE-NGQIAVGWKKINGNWYHLQADGRMTTGWLKDGSNWYYLKSSGEMQTGWLKDKGIWYY 326
Cdd:NF033838  558 LNANGAMATGWLQYNGSWYYLNaNGDMATGWLQYNGSWYYLNANGDMATGWLQYNGSWYYLNANGSMATGWVKDGDTWYY 637

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1080605215 327 LESSGAMKTNQWFQVSGKHYYVNASGELAVNTTIDGFQVDGDG 369
Cdd:NF033838  638 LEASGAMKASQWFKVSDKWYYVNGSGALAVNTTVDGYGVNANG 680
pneumo_PspA NF033930
pneumococcal surface protein A; The pneumococcal surface protein proteins, found in ...
 247-355 1.78e-34

pneumococcal surface protein A; The pneumococcal surface protein proteins, found in Streptococcus pneumoniae, are repetitive, with patterns of localized high sequence identity across pairs of proteins given different specific names that recombination may be presumed. This protein, PspA, has an N-terminal region that lacks a cross-wall-targeting YSIRK type extended signal peptide, in contrast to the closely related choline-binding protein CbpA which has a similar C-terminus but a YSIRK-containing region at the N-terminus.


Pssm-ID: 468251 [Multi-domain]  Cd Length: 660  Bit Score: 134.27  E-value: 1.78e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215 247 PLTKTGSSKNGWAKEGTSWYYYE-NGQIAVGWKKINGNWYHLQADGRMTTGWLKDGSNWYYLKSSGEMQTGWLKDKGIWY 325
Cdd:NF033930  434 PEQPAPAPKTGWKQENGMWYFYNtDGSMATGWLQNNGSWYYLNSNGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWY 513

                          90       100       110
                  ....*....|....*....|....*....|
gi 1080605215 326 YLESSGAMKTNqWFQVSGKHYYVNASGELA 355
Cdd:NF033930  514 YLNANGAMATG-WLQYNGSWYYLNANGAMA 542
COG5263 COG5263
Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism];
11-372 5.29e-30

Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism];


Pssm-ID: 444077 [Multi-domain]  Cd Length: 486  Bit Score: 120.36  E-value: 5.29e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215  11 GTFLRKTAVGSASLLLAGVFLFGGGTVHANQANNGSLARGDDYPYYYKNGSQKIDKWRMYSGQCTSFAAFRLSSVNGFEL 90
Cdd:COG5263   137 GGKTKKGDTNSANTGYLGDDLGGGTADKGGSAGYGAGKDGATAAAKELVGSAADTYYGGASTYLTGDAGAYGALGLAAGS 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215  91 PAAYGNANQWGYRAQKEGYRVDQQPAIGAIAWSTRGQYGHVAWVSNVIGDMIEIEEYNYDYTETYHSRIVKASSMTGFIH 170
Cdd:COG5263   217 GAGAKKTGSTAGASGTAYGDSGGTAGSGLSSLGGSSNALESGGENNQSLAGNGTSYDDAGAAGVDGTGTTGTVGWVDGKW 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215 171 FKDVGNASVGHHQSllaFSGTHHFTEKSAIMdqpsltstVIDYYEAGMSVHYdqtFEKEGYKWISYISRSGNRRYipLTK 250
Cdd:COG5263   297 YYFDAGKMVTGWQT---INGKWYYFDSDGAM--------ATGWQKINGKWYY---FDEDGAMATGWVTDDGKWYY--LGS 360

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215 251 TGSSKNGWAKEGTSWYYY-ENGQIAVGWKKINGNWYHLQADGRMTTGWLKDGSNWYYLKSSGEMQTGWLKDKGIWYYLES 329
Cdd:COG5263   361 DGAMATGWQKIDGKWYYFdSNGAMATGWVKVDGKWYYFDSSGAMATGWLKIDGKWYYFDSDGAMATGWQKIGGKWYYFDS 440

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1080605215 330 SGAMKTNqWFQVSGKHYYVNASGELAVNT-TIDG--FQVDGDGVRV 372
Cdd:COG5263   441 NGAMATG-WVKVDGKWYYFDSDGAMATGWqTIDGktYYFDSNGAWV 485
COG3942 COG3942
Surface antigen [Cell wall/membrane/envelope biogenesis];
44-172 1.18e-28

Surface antigen [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443142 [Multi-domain]  Cd Length: 129  Bit Score: 108.16  E-value: 1.18e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215  44 NGSLARGDDYPYyykngsQKIDKWRMYS-GQCTSFAAFRLSSVNGFeLPAAYGNANQWGYRAQKEGYRVDQQPAIGAIAW 122
Cdd:COG3942     1 ARAASLGDGYPP------NVVDPWNGYPyGQCTWYAAWRRAQLGGP-IGSGWGNANNWADNARAAGYTVGSTPKVGAVAV 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1080605215 123 STRGQ---YGHVAWVSNVIGD-MIEIEEYNYDYTETYHSRIVKAS--SMTGFIHFK 172
Cdd:COG3942    74 FTPGVagpYGHVAVVESVNSDgSILVSEMNWGGPGIYSTRTISAGnaSSYGFIHPK 129
COG5263 COG5263
Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism];
248-335 2.83e-20

Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism];


Pssm-ID: 444077 [Multi-domain]  Cd Length: 486  Bit Score: 92.24  E-value: 2.83e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215 248 LTKTGSSKNGWAKEGTSWYYY-ENGQIAVGWKKINGNWYHLQADGRMTTGWLKDGSNWYYLKSSGEMQTGWLKDKGIWYY 326
Cdd:COG5263   398 FDSSGAMATGWLKIDGKWYYFdSDGAMATGWQKIGGKWYYFDSNGAMATGWVKVDGKWYYFDSDGAMATGWQTIDGKTYY 477


                  ....*....
gi 1080605215 327 LESSGAMKT 335
Cdd:COG5263   478 FDSNGAWVG 486
SH3_5 pfam08460
Bacterial SH3 domain;
189-248 1.11e-13

Bacterial SH3 domain;


Pssm-ID: 430010 [Multi-domain]  Cd Length: 68  Bit Score: 65.48  E-value: 1.11e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1080605215 189 SGTHHFTEKSAIMD---QPSLTSTVIDYYEAGMSVHYDQTFEKEGYKWISYISRSGNRRYIPL 248
Cdd:pfam08460   6 QGTFTIGGKTGIVLrknEPSLSAPVQFVLYKGDKVFYDQVLLADGYVWISYTSYNGVRRYLPV 68
CHAP pfam05257
CHAP domain; This domain corresponds to an amidase function. Many of these proteins are ...
 65-148 1.65e-12

CHAP domain; This domain corresponds to an amidase function. Many of these proteins are involved in cell wall metabolism of bacteria. This domain is found at the N-terminus of Swiss:P43675, where it functions as a glutathionylspermidine amidase EC:3.5.1.78. This domain is found to be the catalytic domain of PlyCA. CHAP is the amidase domain of bifunctional Escherichia coli glutathionylspermidine synthetase/amidase, and it catalyzes the hydrolysis of Gsp (glutathionylspermidine) into glutathione and spermidine.


Pssm-ID: 461605 [Multi-domain]  Cd Length: 83  Bit Score: 62.44  E-value: 1.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215  65 DKWRMYSGQCTSFAAFRLSSVNGFelpaaYGNANQWGYRAQKEGYRVDQQPAIGAIAWSTRGQ----YGHVAWVSNVIGD 140
Cdd:pfam05257   1 YGNGYPWGQCTWFVYWRVAQLGIY-----LGNAGDWADAAAGAYKVGSTTPKVGDIVVFDPGGggasYGHVAIVEKVNDG 75


                  ....*...
gi 1080605215 141 MIEIEEYN 148
Cdd:pfam05257  76 SITVSEQN 83
Choline_bind_3 pfam19127
Choline-binding repeat; Pair of presumed choline-binding repeats often found adjacent to ...
 274-338 5.43e-08

Choline-binding repeat; Pair of presumed choline-binding repeats often found adjacent to pfam01473.


Pssm-ID: 465978 [Multi-domain]  Cd Length: 47  Bit Score: 48.69  E-value: 5.43e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1080605215 274 AVGWKKINGNWYHLQADGRMTTGWLK-DGSNWYylkssgemqtgwlkdkgiwYYLESSGAMKTNQW 338
Cdd:pfam19127   1 VTGWQTINGQTLYFDSDGKQVKGWVVtIDGKWY-------------------YFDADSGEMVTNRF 47
PRK08581 PRK08581
amidase domain-containing protein;
72-148 1.15e-05

amidase domain-containing protein;


Pssm-ID: 236304 [Multi-domain]  Cd Length: 619  Bit Score: 47.09  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1080605215  72 GQCTSFAAFRL----SSVNGFelpaaYGNANQWGYRAQKEGYRVDQQPAIGAIAWSTRGQ------YGHVAWVSNVIGD- 140
Cdd:PRK08581  511 GQCTWYVYNRMkqfgTSISGD-----LGDAHNWNNRAQARGYQVSHTPKRHAAVVFEAGQagadqhYGHVAFVEKVNSDg 585


                  ....*...
gi 1080605215 141 MIEIEEYN 148
Cdd:PRK08581  586 SIVISESN 593
Choline_bind_3 pfam19127
Choline-binding repeat; Pair of presumed choline-binding repeats often found adjacent to ...
 315-358 1.69e-05

Choline-binding repeat; Pair of presumed choline-binding repeats often found adjacent to pfam01473.


Pssm-ID: 465978 [Multi-domain]  Cd Length: 47  Bit Score: 41.76  E-value: 1.69e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1080605215 315 TGWLKDKGIWYYLESSGAMKTNQWFQVSGKHYYVNA-SGELAVNT 358
Cdd:pfam19127   2 TGWQTINGQTLYFDSDGKQVKGWVVTIDGKWYYFDAdSGEMVTNR 46
glucan_65_rpt TIGR04035
glucan-binding repeat; This model describes a region of about 63 amino acids that is composed ...
 266-343 7.35e-04

glucan-binding repeat; This model describes a region of about 63 amino acids that is composed of three repeats of a more broadly distributed family of shorter repeats modeled by pfam01473. While the shorter repeats are often associated with choline binding (and therefore with cell wall binding), the longer repeat described here represents a subgroup of repeat sequences associated with glucan binding, as found in a number glycosylhydrolases. Shah, et al. describe a repeat consensus, WYYFDANGKAVTGAQTINGQTLYFDQDGKQVKG, that corresponds to half of the repeat as modeled here and one and a half copies of the repeat as modeled by pfam01473.


Pssm-ID: 274933 [Multi-domain]  Cd Length: 62  Bit Score: 37.50  E-value: 7.35e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1080605215 266 YYYENGQIAVGWKKINGNWYHLQADGRMTTG-WLKDGSNWYylkssgemqtgwlkdkgiwYYLESSGAMKTNQWFQVSG 343
Cdd:TIGR04035   2 YFDADGKAVTGAQTIDGVTYYFDENGKQVKGdFVTNGGGTY-------------------YYDKDSGALVTNRFVTIKD 61
Choline_bind_1 pfam01473
Putative cell wall binding repeat; These repeats are characterized by conserved aromatic ...
 295-313 7.52e-04

Putative cell wall binding repeat; These repeats are characterized by conserved aromatic residues and glycines are found in multiple tandem copies in a number of proteins. The CW repeat is 20 amino acid residues long. The exact domain boundaries may not be correct. It has been suggested that these repeats in Swiss:P15057 might be responsible for the specific recognition of choline-containing cell walls. Similar but longer repeats are found in the glucosyltransferases and glucan-binding proteins of oral streptococci and shown to be involved in glucan binding as well as in the related dextransucrases of Leuconostoc mesenteroides. Repeats also occur in toxins of Clostridium difficile and other clostridia, though the ligands are not always known.


Pssm-ID: 366661 [Multi-domain]  Cd Length: 19  Bit Score: 36.60  E-value: 7.52e-04
                          10
                  ....*....|....*....
gi 1080605215 295 TGWLKDGSNWYYLKSSGEM 313
Cdd:pfam01473   1 TGWVKINGNWYYFDSNGVM 19
Choline_bind_1 pfam01473
Putative cell wall binding repeat; These repeats are characterized by conserved aromatic ...
 315-333 3.33e-03

Putative cell wall binding repeat; These repeats are characterized by conserved aromatic residues and glycines are found in multiple tandem copies in a number of proteins. The CW repeat is 20 amino acid residues long. The exact domain boundaries may not be correct. It has been suggested that these repeats in Swiss:P15057 might be responsible for the specific recognition of choline-containing cell walls. Similar but longer repeats are found in the glucosyltransferases and glucan-binding proteins of oral streptococci and shown to be involved in glucan binding as well as in the related dextransucrases of Leuconostoc mesenteroides. Repeats also occur in toxins of Clostridium difficile and other clostridia, though the ligands are not always known.


Pssm-ID: 366661 [Multi-domain]  Cd Length: 19  Bit Score: 34.67  E-value: 3.33e-03
                          10
                  ....*....|....*....
gi 1080605215 315 TGWLKDKGIWYYLESSGAM 333
Cdd:pfam01473   1 TGWVKINGNWYYFDSNGVM 19
Choline_bind_1 pfam01473
Putative cell wall binding repeat; These repeats are characterized by conserved aromatic ...
 276-293 4.83e-03

Putative cell wall binding repeat; These repeats are characterized by conserved aromatic residues and glycines are found in multiple tandem copies in a number of proteins. The CW repeat is 20 amino acid residues long. The exact domain boundaries may not be correct. It has been suggested that these repeats in Swiss:P15057 might be responsible for the specific recognition of choline-containing cell walls. Similar but longer repeats are found in the glucosyltransferases and glucan-binding proteins of oral streptococci and shown to be involved in glucan binding as well as in the related dextransucrases of Leuconostoc mesenteroides. Repeats also occur in toxins of Clostridium difficile and other clostridia, though the ligands are not always known.


Pssm-ID: 366661 [Multi-domain]  Cd Length: 19  Bit Score: 34.28  E-value: 4.83e-03
                          10
                  ....*....|....*...
gi 1080605215 276 GWKKINGNWYHLQADGRM 293
Cdd:pfam01473   2 GWVKINGNWYYFDSNGVM 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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