|
Name |
Accession |
Description |
Interval |
E-value |
| BirA2 |
COG0340 |
Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]; Biotin-(acetyl-CoA ... |
80-325 |
1.98e-85 |
|
Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]; Biotin-(acetyl-CoA carboxylase) ligase is part of the Pathway/BioSystem: Biotin biosynthesis
Pssm-ID: 440109 [Multi-domain] Cd Length: 241 Bit Score: 257.02 E-value: 1.98e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 80 NIICLPSVDSTNNILKSMLPDQPPAGTCIIANEQTGGRGRMGRSFISPPNTGIYLSMLLRPQSAVADISEITCWTAVAVH 159
Cdd:COG0340 1 RIEVFDEVDSTNDEAKELAREGAPEGTVVVAEEQTAGRGRRGRSWVSPPGKGLYFSLLLRPDLPPARLPLLSLAAGLAVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 160 RAILSVFDIRTDIKWVNDLFLNGRKITGILTEMSveGEIGMISNIIVGIGVNVRQRPEDfPPELRETASSLGIYSGnYEL 239
Cdd:COG0340 81 EALRELTGVDVGLKWPNDILLNGKKLAGILIEAS--GEGDGIDWVVIGIGINVNQPPFD-PEELDQPATSLKEETG-KEV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 240 SRAALAAAMIRELDRMNDSWPSDK-SSYFNTYRDNCVTVGKNVDVTNyaTGAVRHGYAVDVNEDFSLKVRFENGDTEDVR 318
Cdd:COG0340 157 DREELLAALLEELEELYDRFLEEGfAPILEEWRARLATLGRRVRVET--GGETLEGIAVGIDEDGALLLETADGEIRAVA 234
|
....*..
gi 1079632717 319 SGEVSVK 325
Cdd:COG0340 235 AGEVSLR 241
|
|
| BPL |
cd16442 |
biotin protein ligase; Biotin protein ligase (EC 6.3.4.15) catalyzes the synthesis of an ... |
80-254 |
1.15e-59 |
|
biotin protein ligase; Biotin protein ligase (EC 6.3.4.15) catalyzes the synthesis of an activated form of biotin, biotinyl-5'-AMP, from substrates biotin and ATP followed by biotinylation of the biotin carboxyl carrier protein subunit of acetyl-CoA carboxylase. Biotin protein ligase (BPL) is the enzyme responsible for attaching biotin to a specific lysine at the active site of biotin enzymes. Biotin attachment is a two step reaction that results in the formation of an amide linkage between the carboxyl group of biotin and the epsilon-amino group of the modified lysine.
Pssm-ID: 319741 [Multi-domain] Cd Length: 173 Bit Score: 189.01 E-value: 1.15e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 80 NIICLPSVDSTNNILKSMLPDQPPAGTCIIANEQTGGRGRMGRSFISPPNTGIYLSMLLRPQSAVADISEITCWTAVAVH 159
Cdd:cd16442 1 KLIVLDEIDSTNDEAKELARSGAPEGTVVVAEEQTAGRGRRGRKWESPKGKGLYFSLLLRPDVPPAEAPLLTLLAAVAVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 160 RAILSVFDIRTDIKWVNDLFLNGRKITGILTEMSVEGEigMISNIIVGIGVNVRQRPEDFPPELRETASSLGIysgnyEL 239
Cdd:cd16442 81 EALEKLGGIPVQIKWPNDILVNGKKLAGILTEASAEGE--GVAAVVIGIGINVNNTPPPEPLPDTSLATSLGK-----EV 153
|
170
....*....|....*
gi 1079632717 240 SRAALAAAMIRELDR 254
Cdd:cd16442 154 DRNELLEELLAALEN 168
|
|
| PRK11886 |
PRK11886 |
bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA; |
1-324 |
7.83e-58 |
|
bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA;
Pssm-ID: 237010 [Multi-domain] Cd Length: 319 Bit Score: 189.23 E-value: 7.83e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 1 MTKDEVLAILiKKADYVSGESISSEIGVSRAAVNGAVKSLKADGCLIDSVTNKGYRLISCPDRLYAGEIYAYLNKERCSn 80
Cdd:PRK11886 4 TVMLQLLSLL-ADGDFHSGEQLGEELGISRAAIWKHIQTLEEWGLDIFSVKGKGYRLAEPLDLLDPERISSQLPPGRVT- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 81 iiCLPSVDSTNNILKsMLPDQPPAGTCIIANEQTGGRGRMGRSFISPPNTGIYLSMLLRPQSAVADISEITCWTAVAVHR 160
Cdd:PRK11886 82 --VLPVIDSTNQYLL-DRIAELKSGDLCLAEYQTAGRGRRGRQWFSPFGGNLYLSLYWRLNQGPAQAMGLSLVVGIAIAE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 161 AILSVFDIRTDIKWVNDLFLNGRKITGILTEMSveGEIGMISNIIVGIGVNVRQRpeDFPPELRETA----SSLGIysgn 236
Cdd:PRK11886 159 ALRRLGAIDVGLKWPNDIYLNDRKLAGILVELS--GETGDAAHVVIGIGINVAMP--DFPEELIDQPwsdlQEAGP---- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 237 yELSRAALAAAMIRELDR-MNDSWPSDKSSYFNTYRDNCVTVGKNVDVTnyaTGAVR-HGYAVDVNEDFSLKVRfENGDT 314
Cdd:PRK11886 231 -TIDRNQLAAELIKQLRAaLELFEQEGLAPFLERWKKLDLFLGREVKLI---IGDKEiSGIARGIDEQGALLLE-DDGVE 305
|
330
....*....|
gi 1079632717 315 EDVRSGEVSV 324
Cdd:PRK11886 306 KPFNGGEISL 315
|
|
| birA_ligase |
TIGR00121 |
birA, biotin-[acetyl-CoA-carboxylase] ligase region; This model represents the ... |
81-323 |
1.16e-42 |
|
birA, biotin-[acetyl-CoA-carboxylase] ligase region; This model represents the biotin--acetyl-CoA-carboxylase ligase region of biotin--acetyl-CoA-carboxylase ligase. In Escherichia coli and some other species, this enzyme is part of a bifunction protein BirA that includes a small, N-terminal biotin operon repressor domain. Proteins identified by this model should not be called bifunctional unless they are also identified by birA_repr_reg (TIGR00122). The protein name suggests that this enzyme transfers biotin only to acetyl-CoA-carboxylase but it also transfers the biotin moiety to other proteins. The apparent orthologs among the eukaryotes are larger proteins that contain a single copy of this domain. [Protein fate, Protein modification and repair]
Pssm-ID: 272917 [Multi-domain] Cd Length: 237 Bit Score: 147.16 E-value: 1.16e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 81 IICLPSVDSTNNILKSMLPDQPPAGTCIIANEQTGGRGRMGRSFISPPNtGIYLSMLLRPQSAVADISEITCWTAVAVHR 160
Cdd:TIGR00121 2 VIVLDVIDSTNQYALELAKEGKLKGDLVVAEYQTAGRGRRGRKWLSPEG-GLYFSLILRPDLPKSPAPGLTLVAGIAIAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 161 AiLSVFDIRTDIKWVNDLFLNGRKITGILTEMSveGEIGMISNIIVGIGVNVRQRpeDFPPELRETASSLGIYSGnYELS 240
Cdd:TIGR00121 81 V-LKELGDQVQVKWPNDILLKDKKLGGILTELT--GKENRADYVVIGIGINVQNR--KPAESLREQAISLSEEAG-IDLD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 241 RAALAAAMIRELD-RMNDSWPSDKSSYFNTYRDNCVTVGKNVDVTNYATGAVrhGYAVDVNEDFSLKVRfENGDTEDVRS 319
Cdd:TIGR00121 155 RGELIEGFLRNFEeNLEWFEQEGIDEILSKWEKLSAHIGREVSLTTGNGEIE--GIARGIDKDGALLLE-DGGGIKKIIS 231
|
....
gi 1079632717 320 GEVS 323
Cdd:TIGR00121 232 GEIS 235
|
|
| BPL_LplA_LipB |
pfam03099 |
Biotin/lipoate A/B protein ligase family; This family includes biotin protein ligase, ... |
85-211 |
6.35e-18 |
|
Biotin/lipoate A/B protein ligase family; This family includes biotin protein ligase, lipoate-protein ligase A and B. Biotin is covalently attached at the active site of certain enzymes that transfer carbon dioxide from bicarbonate to organic acids to form cellular metabolites. Biotin protein ligase (BPL) is the enzyme responsible for attaching biotin to a specific lysine at the active site of biotin enzymes. Each organizm probably has only one BPL. Biotin attachment is a two step reaction that results in the formation of an amide linkage between the carboxyl group of biotin and the epsilon-amino group of the modified lysine. Lipoate-protein ligase A (LPLA) catalyzes the formation of an amide linkage between lipoic acid and a specific lysine residue in lipoate dependent enzymes. The unusual biosynthesis pathway of lipoic acid is mechanistically intertwined with attachment of the cofactor.
Pssm-ID: 427135 Cd Length: 132 Bit Score: 78.64 E-value: 6.35e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 85 PSVDSTNNILKSMLPDQPPAGTCIIANEQTGGRGRMGRSFISPPNtGIYLSMLLRPQSAVADISEI---TCWTAVAVHRA 161
Cdd:pfam03099 3 ERIKSTNTYLEELNSSELESGGVVVVRRQTGGRGRGGNVWHSPKG-CLTYSLLLSKEHPNVDPSVLefyVLELVLAVLEA 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1079632717 162 ILSVF----DIRTDIKWVNDLFLNGRKITGILTEmSVEGEIgmISNIIVGIGVN 211
Cdd:pfam03099 82 LGLYKpgisGIPCFVKWPNDLYVNGRKLAGILQR-STRGGT--LHHGVIGLGVN 132
|
|
| HTH_11 |
pfam08279 |
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins. |
6-55 |
1.90e-09 |
|
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
Pssm-ID: 429896 [Multi-domain] Cd Length: 52 Bit Score: 52.82 E-value: 1.90e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1079632717 6 VLAILIKKADYVSGESISSEIGVSRAAVNGAVKSLKADGCLIDSVTNKGY 55
Cdd:pfam08279 3 ILQLLLEARGPISGQELAEKLGVSRRTIRRDIKILEELGVPIEAEPGRGY 52
|
|
| MntR |
COG1321 |
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription]; |
5-57 |
4.75e-04 |
|
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
Pssm-ID: 440932 [Multi-domain] Cd Length: 135 Bit Score: 39.80 E-value: 4.75e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1079632717 5 EVLAILIKKADYVSGESISSEIGVSRAAVNGAVKSLKADGcLIDSVTNKGYRL 57
Cdd:COG1321 13 KAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKG-LVEYEPYGGITL 64
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| BirA2 |
COG0340 |
Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]; Biotin-(acetyl-CoA ... |
80-325 |
1.98e-85 |
|
Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme transport and metabolism]; Biotin-(acetyl-CoA carboxylase) ligase is part of the Pathway/BioSystem: Biotin biosynthesis
Pssm-ID: 440109 [Multi-domain] Cd Length: 241 Bit Score: 257.02 E-value: 1.98e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 80 NIICLPSVDSTNNILKSMLPDQPPAGTCIIANEQTGGRGRMGRSFISPPNTGIYLSMLLRPQSAVADISEITCWTAVAVH 159
Cdd:COG0340 1 RIEVFDEVDSTNDEAKELAREGAPEGTVVVAEEQTAGRGRRGRSWVSPPGKGLYFSLLLRPDLPPARLPLLSLAAGLAVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 160 RAILSVFDIRTDIKWVNDLFLNGRKITGILTEMSveGEIGMISNIIVGIGVNVRQRPEDfPPELRETASSLGIYSGnYEL 239
Cdd:COG0340 81 EALRELTGVDVGLKWPNDILLNGKKLAGILIEAS--GEGDGIDWVVIGIGINVNQPPFD-PEELDQPATSLKEETG-KEV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 240 SRAALAAAMIRELDRMNDSWPSDK-SSYFNTYRDNCVTVGKNVDVTNyaTGAVRHGYAVDVNEDFSLKVRFENGDTEDVR 318
Cdd:COG0340 157 DREELLAALLEELEELYDRFLEEGfAPILEEWRARLATLGRRVRVET--GGETLEGIAVGIDEDGALLLETADGEIRAVA 234
|
....*..
gi 1079632717 319 SGEVSVK 325
Cdd:COG0340 235 AGEVSLR 241
|
|
| BirA |
COG1654 |
Biotin operon repressor [Transcription]; |
1-325 |
5.19e-66 |
|
Biotin operon repressor [Transcription];
Pssm-ID: 441260 [Multi-domain] Cd Length: 324 Bit Score: 210.61 E-value: 5.19e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 1 MTKDEVLAILiKKADYVSGESISSEIGVSRAAVNGAVKSLKADGCLIDSVTNKGYRLISCPDRLYAGEIYAYLN-KERCS 79
Cdd:COG1654 4 STRLKLLRLL-ADGEFHSGEELAEELGVSRAAVWKHIKALRELGYEIESVPGKGYRLAEPPDLLDPEEIRAGLStKRLGR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 80 NIICLPSVDSTNNILKSMLPDQPPAGTCIIANEQTGGRGRMGRSFISPPNTGIYLSMLLRPQSAVADISEITCWTAVAVH 159
Cdd:COG1654 83 EILYVISSTSTNLLALELAAQGGDAGTVVAAEQQRGGRGRRRRSWSSPGGGGLLYSLLLRPPIAPALLSLLLLAAAVAVA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 160 RAILSVFDIRTDIKWVNDLFLNGRKITGILTEMSVEGEIGMIsnIIVGIGVNVRQRPEDFPPELRETASSLGIYSGNYEL 239
Cdd:COG1654 163 AALAEGGGLVKWKKWPNDLLKKGKKILGILEEEGGDADGVVI--VVGGGGNNNNSNPEEEPQELAELATSLLLILRLRLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 240 SRAALAAAMIRELDRMNDSWPSDKSSYFNTYRDNCVTVGKNVDVTNYatGAVRHGYAVDVNEDFSLKVRFENGDTEDVRS 319
Cdd:COG1654 241 RLLLLLLLLLLELLELLGFLEFFFLWERLDWELLRVLKLVVVVVEIG--GGGGGGGALGGGLLGLLLLGGGGGGGEGSLS 318
|
....*.
gi 1079632717 320 GEVSVK 325
Cdd:COG1654 319 AVVVLL 324
|
|
| BPL |
cd16442 |
biotin protein ligase; Biotin protein ligase (EC 6.3.4.15) catalyzes the synthesis of an ... |
80-254 |
1.15e-59 |
|
biotin protein ligase; Biotin protein ligase (EC 6.3.4.15) catalyzes the synthesis of an activated form of biotin, biotinyl-5'-AMP, from substrates biotin and ATP followed by biotinylation of the biotin carboxyl carrier protein subunit of acetyl-CoA carboxylase. Biotin protein ligase (BPL) is the enzyme responsible for attaching biotin to a specific lysine at the active site of biotin enzymes. Biotin attachment is a two step reaction that results in the formation of an amide linkage between the carboxyl group of biotin and the epsilon-amino group of the modified lysine.
Pssm-ID: 319741 [Multi-domain] Cd Length: 173 Bit Score: 189.01 E-value: 1.15e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 80 NIICLPSVDSTNNILKSMLPDQPPAGTCIIANEQTGGRGRMGRSFISPPNTGIYLSMLLRPQSAVADISEITCWTAVAVH 159
Cdd:cd16442 1 KLIVLDEIDSTNDEAKELARSGAPEGTVVVAEEQTAGRGRRGRKWESPKGKGLYFSLLLRPDVPPAEAPLLTLLAAVAVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 160 RAILSVFDIRTDIKWVNDLFLNGRKITGILTEMSVEGEigMISNIIVGIGVNVRQRPEDFPPELRETASSLGIysgnyEL 239
Cdd:cd16442 81 EALEKLGGIPVQIKWPNDILVNGKKLAGILTEASAEGE--GVAAVVIGIGINVNNTPPPEPLPDTSLATSLGK-----EV 153
|
170
....*....|....*
gi 1079632717 240 SRAALAAAMIRELDR 254
Cdd:cd16442 154 DRNELLEELLAALEN 168
|
|
| PRK11886 |
PRK11886 |
bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA; |
1-324 |
7.83e-58 |
|
bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA;
Pssm-ID: 237010 [Multi-domain] Cd Length: 319 Bit Score: 189.23 E-value: 7.83e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 1 MTKDEVLAILiKKADYVSGESISSEIGVSRAAVNGAVKSLKADGCLIDSVTNKGYRLISCPDRLYAGEIYAYLNKERCSn 80
Cdd:PRK11886 4 TVMLQLLSLL-ADGDFHSGEQLGEELGISRAAIWKHIQTLEEWGLDIFSVKGKGYRLAEPLDLLDPERISSQLPPGRVT- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 81 iiCLPSVDSTNNILKsMLPDQPPAGTCIIANEQTGGRGRMGRSFISPPNTGIYLSMLLRPQSAVADISEITCWTAVAVHR 160
Cdd:PRK11886 82 --VLPVIDSTNQYLL-DRIAELKSGDLCLAEYQTAGRGRRGRQWFSPFGGNLYLSLYWRLNQGPAQAMGLSLVVGIAIAE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 161 AILSVFDIRTDIKWVNDLFLNGRKITGILTEMSveGEIGMISNIIVGIGVNVRQRpeDFPPELRETA----SSLGIysgn 236
Cdd:PRK11886 159 ALRRLGAIDVGLKWPNDIYLNDRKLAGILVELS--GETGDAAHVVIGIGINVAMP--DFPEELIDQPwsdlQEAGP---- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 237 yELSRAALAAAMIRELDR-MNDSWPSDKSSYFNTYRDNCVTVGKNVDVTnyaTGAVR-HGYAVDVNEDFSLKVRfENGDT 314
Cdd:PRK11886 231 -TIDRNQLAAELIKQLRAaLELFEQEGLAPFLERWKKLDLFLGREVKLI---IGDKEiSGIARGIDEQGALLLE-DDGVE 305
|
330
....*....|
gi 1079632717 315 EDVRSGEVSV 324
Cdd:PRK11886 306 KPFNGGEISL 315
|
|
| birA_ligase |
TIGR00121 |
birA, biotin-[acetyl-CoA-carboxylase] ligase region; This model represents the ... |
81-323 |
1.16e-42 |
|
birA, biotin-[acetyl-CoA-carboxylase] ligase region; This model represents the biotin--acetyl-CoA-carboxylase ligase region of biotin--acetyl-CoA-carboxylase ligase. In Escherichia coli and some other species, this enzyme is part of a bifunction protein BirA that includes a small, N-terminal biotin operon repressor domain. Proteins identified by this model should not be called bifunctional unless they are also identified by birA_repr_reg (TIGR00122). The protein name suggests that this enzyme transfers biotin only to acetyl-CoA-carboxylase but it also transfers the biotin moiety to other proteins. The apparent orthologs among the eukaryotes are larger proteins that contain a single copy of this domain. [Protein fate, Protein modification and repair]
Pssm-ID: 272917 [Multi-domain] Cd Length: 237 Bit Score: 147.16 E-value: 1.16e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 81 IICLPSVDSTNNILKSMLPDQPPAGTCIIANEQTGGRGRMGRSFISPPNtGIYLSMLLRPQSAVADISEITCWTAVAVHR 160
Cdd:TIGR00121 2 VIVLDVIDSTNQYALELAKEGKLKGDLVVAEYQTAGRGRRGRKWLSPEG-GLYFSLILRPDLPKSPAPGLTLVAGIAIAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 161 AiLSVFDIRTDIKWVNDLFLNGRKITGILTEMSveGEIGMISNIIVGIGVNVRQRpeDFPPELRETASSLGIYSGnYELS 240
Cdd:TIGR00121 81 V-LKELGDQVQVKWPNDILLKDKKLGGILTELT--GKENRADYVVIGIGINVQNR--KPAESLREQAISLSEEAG-IDLD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 241 RAALAAAMIRELD-RMNDSWPSDKSSYFNTYRDNCVTVGKNVDVTNYATGAVrhGYAVDVNEDFSLKVRfENGDTEDVRS 319
Cdd:TIGR00121 155 RGELIEGFLRNFEeNLEWFEQEGIDEILSKWEKLSAHIGREVSLTTGNGEIE--GIARGIDKDGALLLE-DGGGIKKIIS 231
|
....
gi 1079632717 320 GEVS 323
Cdd:TIGR00121 232 GEIS 235
|
|
| PRK08330 |
PRK08330 |
biotin--protein ligase; Provisional |
80-325 |
5.73e-35 |
|
biotin--protein ligase; Provisional
Pssm-ID: 169384 [Multi-domain] Cd Length: 236 Bit Score: 127.17 E-value: 5.73e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 80 NIICLPSVDSTNNILKSMLPDQPpAGTCIIANEQTGGRGRMGRSFISPPNtGIYLSMLLRPQSAVADISEITCWTAVAVH 159
Cdd:PRK08330 4 NIIYFDEVDSTNEYAKRIAPDEE-EGTVIVADRQTAGHGRKGRAWASPEG-GLWMSVILKPKVSPEHLPKLVFLGALAVV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 160 RAiLSVFDIRTDIKWVNDLFLNGRKITGILTEMSVEgeigmisNIIVGIGVNVRQrpeDFPPELRETASSLGIYSGNyEL 239
Cdd:PRK08330 82 DT-LREFGIEGKIKWPNDVLVNYKKIAGVLVEGKGD-------FVVLGIGLNVNN---EIPDELRETATSMKEVLGR-EV 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 240 SRAALAAAMIRELDRMNDSWPSDKSSYFNTYRDNCVTVGKNVDVTNYATGAVRhGYAVDVNEDFSLKVRFENGDTEDVRS 319
Cdd:PRK08330 150 PLIEVFKRLVENLDRWYKLFLEGPGEILEEVKGRSMILGKRVKIIGDGEILVE-GIAEDIDEFGALILRLDDGTVKKVLY 228
|
....*.
gi 1079632717 320 GEVSVK 325
Cdd:PRK08330 229 GDVSLR 234
|
|
| BPL_LplA_LipB |
pfam03099 |
Biotin/lipoate A/B protein ligase family; This family includes biotin protein ligase, ... |
85-211 |
6.35e-18 |
|
Biotin/lipoate A/B protein ligase family; This family includes biotin protein ligase, lipoate-protein ligase A and B. Biotin is covalently attached at the active site of certain enzymes that transfer carbon dioxide from bicarbonate to organic acids to form cellular metabolites. Biotin protein ligase (BPL) is the enzyme responsible for attaching biotin to a specific lysine at the active site of biotin enzymes. Each organizm probably has only one BPL. Biotin attachment is a two step reaction that results in the formation of an amide linkage between the carboxyl group of biotin and the epsilon-amino group of the modified lysine. Lipoate-protein ligase A (LPLA) catalyzes the formation of an amide linkage between lipoic acid and a specific lysine residue in lipoate dependent enzymes. The unusual biosynthesis pathway of lipoic acid is mechanistically intertwined with attachment of the cofactor.
Pssm-ID: 427135 Cd Length: 132 Bit Score: 78.64 E-value: 6.35e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 85 PSVDSTNNILKSMLPDQPPAGTCIIANEQTGGRGRMGRSFISPPNtGIYLSMLLRPQSAVADISEI---TCWTAVAVHRA 161
Cdd:pfam03099 3 ERIKSTNTYLEELNSSELESGGVVVVRRQTGGRGRGGNVWHSPKG-CLTYSLLLSKEHPNVDPSVLefyVLELVLAVLEA 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1079632717 162 ILSVF----DIRTDIKWVNDLFLNGRKITGILTEmSVEGEIgmISNIIVGIGVN 211
Cdd:pfam03099 82 LGLYKpgisGIPCFVKWPNDLYVNGRKLAGILQR-STRGGT--LHHGVIGLGVN 132
|
|
| PTZ00276 |
PTZ00276 |
biotin/lipoate protein ligase; Provisional |
80-217 |
2.07e-13 |
|
biotin/lipoate protein ligase; Provisional
Pssm-ID: 140302 [Multi-domain] Cd Length: 245 Bit Score: 68.74 E-value: 2.07e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 80 NIICLPSVDSTNNILKSMLPDQPPAGTCIIANEQTGGRGRMGRSFISPPNTgIYLSMLLrPQSAVAdiSEIT----CWTA 155
Cdd:PTZ00276 8 NIHFVGEVTSTMDVARTMLAAAGGKPFAVLAESQTAGRGTGGRTWTSPKGN-MYFTLCI-PQKGVP--PELVpvlpLITG 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1079632717 156 VAVHRAILSVFDIRT-DIKWVNDLFLNGRKITGILTEmsVEGEigmisNIIVGIGVNVRQRPE 217
Cdd:PTZ00276 84 LACRAAIMEVLHGAAvHTKWPNDIIYAGKKIGGSLIE--SEGE-----YLIIGIGMNIEVAPP 139
|
|
| PRK06955 |
PRK06955 |
biotin--[acetyl-CoA-carboxylase] ligase; |
89-247 |
1.37e-11 |
|
biotin--[acetyl-CoA-carboxylase] ligase;
Pssm-ID: 235896 [Multi-domain] Cd Length: 300 Bit Score: 64.03 E-value: 1.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 89 STNNILKSMLPDQP------PAGTCIIANEQTGGRGRMGRSFISPPNTGIYLSM---LLRPQSAVADISeITCWTAVAVH 159
Cdd:PRK06955 43 STNADLMARLKALPrsadalPAPIVRVAYEQTAGRGRQGRPWFAQPGNALLFSVacvLPRPVAALAGLS-LAVGVALAEA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 160 RAILSV-FDIRTDIKWVNDLFLNGRKITGILTEmSVEGEIGMISNIIvGIGVNVRqRPEDFPPE---LRETASSLGiysg 235
Cdd:PRK06955 122 LAALPAaLGQRIALKWPNDLLIAGRKLAGILIE-TVWATPDATAVVI-GIGLNVR-RADAVAAEvdaLRAREAALA---- 194
|
170
....*....|..
gi 1079632717 236 nYELSRAALAAA 247
Cdd:PRK06955 195 -RGLPPVALAAA 205
|
|
| PRK05935 |
PRK05935 |
biotin--protein ligase; Provisional |
86-211 |
4.35e-10 |
|
biotin--protein ligase; Provisional
Pssm-ID: 235649 [Multi-domain] Cd Length: 190 Bit Score: 58.29 E-value: 4.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 86 SVDSTNNILKSMLPD-QPPAGTCIIANEQTGGRGRMGRSFISpPNTGIYLSMLLRPQSAVADISEITCWTAVAVHRAILS 164
Cdd:PRK05935 10 ETPSTNTTAKEGMHLwDPYALTVISTREQTAGKGKFGKSWHS-SDQDLLASFCFFITVLNIDVSLLFRLGTEAVMRLGED 88
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1079632717 165 VFDIRTDIKWVNDLFLNGRKITGILTE-MSVEGEIGmisnIIVGIGVN 211
Cdd:PRK05935 89 LGITEAVIKWPNDVLVHGEKLCGVLCEtIPVKGGLG----VILGIGVN 132
|
|
| HTH_11 |
pfam08279 |
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins. |
6-55 |
1.90e-09 |
|
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
Pssm-ID: 429896 [Multi-domain] Cd Length: 52 Bit Score: 52.82 E-value: 1.90e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1079632717 6 VLAILIKKADYVSGESISSEIGVSRAAVNGAVKSLKADGCLIDSVTNKGY 55
Cdd:pfam08279 3 ILQLLLEARGPISGQELAEKLGVSRRTIRRDIKILEELGVPIEAEPGRGY 52
|
|
| PRK08477 |
PRK08477 |
biotin--[acetyl-CoA-carboxylase] ligase; |
81-219 |
8.09e-09 |
|
biotin--[acetyl-CoA-carboxylase] ligase;
Pssm-ID: 236273 [Multi-domain] Cd Length: 211 Bit Score: 54.96 E-value: 8.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 81 IICLPSVDSTNNILKSMLPD---QPPagTCIIANEQTGGRGRMGRSFISPPNtGIYLSMLLRPQSAVADI--SEITCWTA 155
Cdd:PRK08477 3 IRVFESLDSTQTYLIEKIKNgelKAP--FAIVAKEQTAGIGSRGNSWEGKKG-NLFFSFALKESDLPKDLplQSSSIYFG 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1079632717 156 VaVHRAILSVFDIRTDIKWVNDLFLNGRKITGILTEMsvegeigMISNIIVGIGVNVRQRPEDF 219
Cdd:PRK08477 80 F-LLKEVLKELGSKVWLKWPNDLYLDDKKIGGVITNK-------IKNFIVCGIGLNLKFSPKNF 135
|
|
| PRK13325 |
PRK13325 |
bifunctional biotin--[acetyl-CoA-carboxylase] ligase/type III pantothenate kinase; |
94-325 |
5.80e-07 |
|
bifunctional biotin--[acetyl-CoA-carboxylase] ligase/type III pantothenate kinase;
Pssm-ID: 183976 [Multi-domain] Cd Length: 592 Bit Score: 50.86 E-value: 5.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 94 LKSMLPDQPPAGTCIiANEQTGGRGRMGRSFISPPNTGIYLSM---LLRPQSAVADISEITcwtAVAVHRAiLSVFDIRT 170
Cdd:PRK13325 100 LARIAPDKAHKTICV-THLQSKGRGRQGRKWSHRLGECLMFSFgwvFDRPQYELGSLSPVA---AVACRRA-LSRLGLKT 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 171 DIKWVNDLFLNGRKITGILTEMSvegEIGMISNIIVGIGVNVRqrpedFPPELRETASSLGIYS-----GNYElsRAALA 245
Cdd:PRK13325 175 QIKWPNDLVVGRDKLGGILIETV---RTGGKTVAVVGIGINFV-----LPKEVENAASVQSLFQtasrrGNAD--AAVLL 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 246 AAMIRELDRMNDSWPSDK-SSYFNTYRDNCVTVGKNVDVTNYATgAVRHGYAVDVNEDFSLKVRFENGDtEDVRSGEVSV 324
Cdd:PRK13325 245 ETLLAELDAVLLQYARDGfAPFVAEYQAANRDHGKAVLLLRDGE-TVFEGTVKGVDGQGVLHLETAEGK-QTVVSGEISL 322
|
.
gi 1079632717 325 K 325
Cdd:PRK13325 323 R 323
|
|
| PTZ00275 |
PTZ00275 |
biotin-acetyl-CoA-carboxylase ligase; Provisional |
108-218 |
2.44e-06 |
|
biotin-acetyl-CoA-carboxylase ligase; Provisional
Pssm-ID: 185536 [Multi-domain] Cd Length: 285 Bit Score: 48.28 E-value: 2.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1079632717 108 IIANEQTGGRG------RMGRSFISPPNTGIYLSMLLRPQSAVADISEITCWTAVAVHRAILSvFDIRTDIKWVNDLFLN 181
Cdd:PTZ00275 53 VSCNEQTNGIGtrdtkkNQDRIWLSEKGNLFTTFVFLWNRNDIEKVKYLAQTCTVAISKTLEY-FHLVTQIKWINDVLVN 131
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1079632717 182 GRKITGILTEMSVEGEIGMISN----IIVGIGVNVRQRPED 218
Cdd:PTZ00275 132 YKKIAGCLVHLYYLDDFPNLNSryvcVMVGIGINVTLEDKH 172
|
|
| MntR |
COG1321 |
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription]; |
5-57 |
4.75e-04 |
|
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
Pssm-ID: 440932 [Multi-domain] Cd Length: 135 Bit Score: 39.80 E-value: 4.75e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1079632717 5 EVLAILIKKADYVSGESISSEIGVSRAAVNGAVKSLKADGcLIDSVTNKGYRL 57
Cdd:COG1321 13 KAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKG-LVEYEPYGGITL 64
|
|
| BPL_LplA_LipB |
cd16435 |
biotin-lipoate ligase family; This family includes biotin protein ligase (BPL), ... |
160-219 |
7.89e-03 |
|
biotin-lipoate ligase family; This family includes biotin protein ligase (BPL), lipoate-protein ligase A (LplA) and octanoyl-[acyl carrier protein]-protein acyltransferase (LipB). Biotin is covalently attached at the active site of certain enzymes that transfer carbon dioxide from bicarbonate to organic acids to form cellular metabolites. Biotin protein ligase (BPL) is the enzyme responsible for attaching biotin to a specific lysine at the active site of biotin enzymes. Biotin attachment is a two step reaction that results in the formation of an amide linkage between the carboxyl group of biotin and the epsilon-amino group of the modified lysine. Lipoate-protein ligase A (LplA) catalyses the formation of an amide linkage between lipoic acid and a specific lysine residue in lipoate dependent enzymes.
Pssm-ID: 319740 Cd Length: 198 Bit Score: 37.13 E-value: 7.89e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1079632717 160 RAILSVFDIRTDIKWV-NDLFLNGRKITGILTEMSVEGeigmisnIIVGIGVNVRQRPEDF 219
Cdd:cd16435 108 RDAIADFGQSAEVKWGrNDLWIDNRKVCGIAVRVVKEA-------IFHGIALNLNQDLENF 161
|
|
|