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Conserved domains on  [gi|1074165668|ref|NP_001333317|]
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diphthine methyltransferase isoform g [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-116 1.45e-09

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 1.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074165668  10 QKVASWQAHQFEAWIAAFnywHP--EIVYSGGDDGLLRGWDTRvPGKFLFTSKRHTMGVCSIQSSPHReHILATGSYDEH 87
Cdd:COG2319   279 ELLRTLTGHSGGVNSVAF---SPdgKLLASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDG-KTLASGSDDGT 353

                          90       100
                  ....*....|....*....|....*....
gi 1074165668  88 ILLWDTRNMKQPLADTPVQGGVWRIKWHP 116
Cdd:COG2319   354 VRLWDLATGELLRTLTGHTGAVTSVAFSP 382
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-116 1.45e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 1.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074165668  10 QKVASWQAHQFEAWIAAFnywHP--EIVYSGGDDGLLRGWDTRvPGKFLFTSKRHTMGVCSIQSSPHReHILATGSYDEH 87
Cdd:COG2319   279 ELLRTLTGHSGGVNSVAF---SPdgKLLASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDG-KTLASGSDDGT 353

                          90       100
                  ....*....|....*....|....*....
gi 1074165668  88 ILLWDTRNMKQPLADTPVQGGVWRIKWHP 116
Cdd:COG2319   354 VRLWDLATGELLRTLTGHTGAVTSVAFSP 382
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-126 4.33e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.11  E-value: 4.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074165668  10 QKVASWQAHQFEAWIAAFNyWHPEIVYSGGDDGLLRGWDTRvPGKFLFTSKRHTMGVCSIQSSPHrEHILATGSYDEHIL 89
Cdd:cd00200    84 ECVRTLTGHTSYVSSVAFS-PDGRILSSSSRDKTIKVWDVE-TGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTIK 160

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1074165668  90 LWDTRNMKqpladtPVQ------GGVWRIKWHPFHHHLLLAAC 126
Cdd:cd00200   161 LWDLRTGK------CVAtltghtGEVNSVAFSPDGEKLLSSSS 197
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 8-100 3.41e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 3.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074165668   8 RLQKVASWQAHQFEAWIAAFNYWHPEIVYSGGDDGLLRGWDTRvPGKFLFTSKRHTmGVCSIQSSPHREHILATGSYDEH 87
Cdd:PLN00181  564 RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSIN-QGVSIGTIKTKA-NICCVQFPSESGRSLAFGSADHK 641

                          90
                  ....*....|...
gi 1074165668  88 ILLWDTRNMKQPL 100
Cdd:PLN00181  642 VYYYDLRNPKLPL 654
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 52-92 1.22e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.22e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1074165668   52 PGKFLFTSKRHTMGVCSIQSSPHrEHILATGSYDEHILLWD 92
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
53-92 1.84e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 1.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1074165668  53 GKFLFTSKRHTMGVCSIQSSPHrEHILATGSYDEHILLWD 92
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
10-116 1.45e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 1.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074165668  10 QKVASWQAHQFEAWIAAFnywHP--EIVYSGGDDGLLRGWDTRvPGKFLFTSKRHTMGVCSIQSSPHReHILATGSYDEH 87
Cdd:COG2319   279 ELLRTLTGHSGGVNSVAF---SPdgKLLASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDG-KTLASGSDDGT 353

                          90       100
                  ....*....|....*....|....*....
gi 1074165668  88 ILLWDTRNMKQPLADTPVQGGVWRIKWHP 116
Cdd:COG2319   354 VRLWDLATGELLRTLTGHTGAVTSVAFSP 382
WD40 COG2319
WD40 repeat [General function prediction only];
10-165 1.87e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.53  E-value: 1.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074165668  10 QKVASWQAHQFEAWIAAFnywHP--EIVYSGGDDGLLRGWDTRvPGKFLFTSKRHTMGVCSIQSSPHREHiLATGSYDEH 87
Cdd:COG2319   237 KLLRTLTGHSGSVRSVAF---SPdgRLLASGSADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFSPDGKL-LASGSDDGT 311

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1074165668  88 ILLWDTRNMKQPLADTPVQGGVWRIKWHPfHHHLLLAACMHSGFKILNcqkaMEERQEATVLTSHTlpdSLVYGADWS 165
Cdd:COG2319   312 VRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWD----LATGELLRTLTGHT---GAVTSVAFS 381
WD40 COG2319
WD40 repeat [General function prediction only];
10-165 2.31e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.53  E-value: 2.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074165668  10 QKVASWQAHQFEAWIAAFnywHP--EIVYSGGDDGLLRGWDTRvPGKFLFTSKRHTMGVCSIQSSPHrEHILATGSYDEH 87
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAF---SPdgKTLASGSADGTVRLWDLA-TGKLLRTLTGHSGAVTSVAFSPD-GKLLASGSDDGT 185

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1074165668  88 ILLWDTRNMKQPLADTPVQGGVWRIKWHPfHHHLLLAACMHSGFKILNcqkaMEERQEATVLTSHTlpdSLVYGADWS 165
Cdd:COG2319   186 VRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWD----LATGKLLRTLTGHS---GSVRSVAFS 255
WD40 COG2319
WD40 repeat [General function prediction only];
10-116 3.74e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.76  E-value: 3.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074165668  10 QKVASWQAHQFEAWIAAFnywHP--EIVYSGGDDGLLRGWDTRvPGKFLFTSKRHTMGVCSIQSSPHReHILATGSYDEH 87
Cdd:COG2319   153 KLLRTLTGHSGAVTSVAF---SPdgKLLASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGT 227

                          90       100
                  ....*....|....*....|....*....
gi 1074165668  88 ILLWDTRNMKQPLADTPVQGGVWRIKWHP 116
Cdd:COG2319   228 VRLWDLATGKLLRTLTGHSGSVRSVAFSP 256
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-126 4.33e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.11  E-value: 4.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074165668  10 QKVASWQAHQFEAWIAAFNyWHPEIVYSGGDDGLLRGWDTRvPGKFLFTSKRHTMGVCSIQSSPHrEHILATGSYDEHIL 89
Cdd:cd00200    84 ECVRTLTGHTSYVSSVAFS-PDGRILSSSSRDKTIKVWDVE-TGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTIK 160

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1074165668  90 LWDTRNMKqpladtPVQ------GGVWRIKWHPFHHHLLLAAC 126
Cdd:cd00200   161 LWDLRTGK------CVAtltghtGEVNSVAFSPDGEKLLSSSS 197
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-153 5.05e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.03  E-value: 5.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074165668  12 VASWQAHQFEAWIAAFNYwHPEIVYSGGDDGLLRGWDTRvPGKFLFTSKRHTMGVCSIQSSPHREHiLATGSYDEHILLW 91
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLE-TGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLW 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1074165668  92 DTRNMKQPLADTPVQGGVWRIKWHPfHHHLLLAACMHSGFKILNcqkaMEERQEATVLTSHT 153
Cdd:cd00200    79 DLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWD----VETGKCLTTLRGHT 135
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-165 2.66e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.71  E-value: 2.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074165668  10 QKVASWQAHqfEAWIAAFNyWHPE--IVYSGGDDGLLRGWDTRvPGKFLFTSKRHTMGVCSIQSSPHREHILATGSyDEH 87
Cdd:cd00200   126 KCLTTLRGH--TDWVNSVA-FSPDgtFVASSSQDGTIKLWDLR-TGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS-DGT 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074165668  88 ILLWDTRnMKQPLAD-TPVQGGVWRIKWHPfhHHLLLAACMHSG-FKILNcqkaMEERQEATVLTSHTlpdSLVYGADWS 165
Cdd:cd00200   201 IKLWDLS-TGKCLGTlRGHENGVNSVAFSP--DGYLLASGSEDGtIRVWD----LRTGECVQTLSGHT---NSVTSLAWS 270
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 56-166 4.49e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.94  E-value: 4.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074165668  56 LFTSKRHTMGVCSIQSSPHREHiLATGSYDEHILLWDTRNMKQPLADTPVQGGVWRIKWHPFHHhlLLAACmhSGFKILN 135
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGT--YLASG--SSDKTIR 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1074165668 136 CQKaMEERQEATVLTSHTlpdSLVYGADWSW 166
Cdd:cd00200    77 LWD-LETGECVRTLTGHT---SYVSSVAFSP 103
WD40 COG2319
WD40 repeat [General function prediction only];
10-95 6.57e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 6.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074165668  10 QKVASWQAHQFEAWIAAFnywHP--EIVYSGGDDGLLRGWDTRvPGKFLFTSKRHTMGVCSIQSSPHrEHILATGSYDEH 87
Cdd:COG2319   321 KLLRTLTGHTGAVRSVAF---SPdgKTLASGSDDGTVRLWDLA-TGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGT 395


                  ....*...
gi 1074165668  88 ILLWDTRN 95
Cdd:COG2319   396 VRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 8-100 3.41e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 3.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074165668   8 RLQKVASWQAHQFEAWIAAFNYWHPEIVYSGGDDGLLRGWDTRvPGKFLFTSKRHTmGVCSIQSSPHREHILATGSYDEH 87
Cdd:PLN00181  564 RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSIN-QGVSIGTIKTKA-NICCVQFPSESGRSLAFGSADHK 641

                          90
                  ....*....|...
gi 1074165668  88 ILLWDTRNMKQPL 100
Cdd:PLN00181  642 VYYYDLRNPKLPL 654
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 52-92 1.22e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.22e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1074165668   52 PGKFLFTSKRHTMGVCSIQSSPHrEHILATGSYDEHILLWD 92
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-92 4.15e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.17  E-value: 4.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074165668  10 QKVASWQAHQFEAWIAAFNyWHPEIVYSGGDDGLLRGWDTRvPGKFLFTSKRHTMGVCSIQSSPHrEHILATGSYDEHIL 89
Cdd:cd00200   210 KCLGTLRGHENGVNSVAFS-PDGYLLASGSEDGTIRVWDLR-TGECVQTLSGHTNSVTSLAWSPD-GKRLASGSADGTIR 286


                  ...
gi 1074165668  90 LWD 92
Cdd:cd00200   287 IWD 289
WD40 pfam00400
WD domain, G-beta repeat;
53-92 1.84e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 1.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1074165668  53 GKFLFTSKRHTMGVCSIQSSPHrEHILATGSYDEHILLWD 92
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
6-116 5.05e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 37.97  E-value: 5.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074165668   6 RPRLQKVASWQAHQFEAWIAAFNYWHPEIVYSGGDDGLLRGWDTRvPGKFLFTSKRHTMGVCSIQSSPHReHILATGSYD 85
Cdd:COG2319    22 AAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAA-AGALLATLLGHTAAVLSVAFSPDG-RLLASASAD 99

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1074165668  86 EHILLWDTRNMKQPLADTPVQGGVWRIKWHP 116
Cdd:COG2319   100 GTVRLWDLATGLLLRTLTGHTGAVRSVAFSP 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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