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Conserved domains on  [gi|1074127292|emb|SCV07832|]
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D-alanine--D-alanine ligase [Bacteroides ovatus V975]

Protein Classification

D-alanine--D-alanine ligase family protein( domain architecture ID 11479728)

D-alanine--D-alanine ligase family protein similar to D-alanine--D-alanine ligase that catalyzes the synthesis of D-alanyl-D-alanine, an essential component of bacterial peptidoglycan, and is involved in cell wall formation

EC:  6.3.2.-
Gene Ontology:  GO:0009252|GO:0008716|GO:0046872|GO:0005524
SCOP:  4002041|4003870

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ddl PRK01966
D-alanine--D-alanine ligase;
1-322 3.10e-136

D-alanine--D-alanine ligase;


:

Pssm-ID: 234993 [Multi-domain]  Cd Length: 333  Bit Score: 389.48  E-value: 3.10e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292   1 MKRNIAIVAGGDTSEIVVSLRSAQGIYSFIDKEKYNLYIVEM-EGRRWEVQLPDGNKVP---VDRNDFSFTNGTEKVV-- 74
Cdd:PRK01966    2 MKMRVALLFGGRSAEHEVSLVSAKSVLKALDKEKYEVVPIGItKDGRWYLIDADNMELAdddNDKEDLSLLILPSGGSee 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292  75 FDFAYITIHGTPGEDGRLQGYFDMMRIPYSCCGVLAAAITYDKFTCNQYLKAFGVRIAESLLLRQGQ--SVSDEEVVEKI 152
Cdd:PRK01966   82 VDVVFPVLHGPPGEDGTIQGLLELLGIPYVGCGVLASALSMDKILTKRLLAAAGIPVAPYVVLTRGDweEASLAEIEAKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 153 GLPCFIKPSLGGSSFGVTKVKTKEQIQPAIVKAFGEAEEVIVEAFMDGTELTCGCYKTKEKsvIFPPTEVVTHNEFFDYD 232
Cdd:PRK01966  162 GLPVFVKPANLGSSVGISKVKNEEELAAALDLAFEYDRKVLVEQGIKGREIECAVLGNDPK--ASVPGEIVKPDDFYDYE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 233 AKYN-GQVDEITPARISDELTKRVQMLTSAIYDILGCSGIIRVDYIITAGEKLNLLEVNTTPGMTTTSFIPQQVRAAGLD 311
Cdd:PRK01966  240 AKYLdGSAELIIPADLSEELTEKIRELAIKAFKALGCSGLARVDFFLTEDGEIYLNEINTMPGFTPISMYPKLWEASGLS 319

                         330
                  ....*....|.
gi 1074127292 312 IKDVMTDIIEN 322
Cdd:PRK01966  320 YPELIDRLIEL 330
 
Name Accession Description Interval E-value
ddl PRK01966
D-alanine--D-alanine ligase;
1-322 3.10e-136

D-alanine--D-alanine ligase;


Pssm-ID: 234993 [Multi-domain]  Cd Length: 333  Bit Score: 389.48  E-value: 3.10e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292   1 MKRNIAIVAGGDTSEIVVSLRSAQGIYSFIDKEKYNLYIVEM-EGRRWEVQLPDGNKVP---VDRNDFSFTNGTEKVV-- 74
Cdd:PRK01966    2 MKMRVALLFGGRSAEHEVSLVSAKSVLKALDKEKYEVVPIGItKDGRWYLIDADNMELAdddNDKEDLSLLILPSGGSee 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292  75 FDFAYITIHGTPGEDGRLQGYFDMMRIPYSCCGVLAAAITYDKFTCNQYLKAFGVRIAESLLLRQGQ--SVSDEEVVEKI 152
Cdd:PRK01966   82 VDVVFPVLHGPPGEDGTIQGLLELLGIPYVGCGVLASALSMDKILTKRLLAAAGIPVAPYVVLTRGDweEASLAEIEAKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 153 GLPCFIKPSLGGSSFGVTKVKTKEQIQPAIVKAFGEAEEVIVEAFMDGTELTCGCYKTKEKsvIFPPTEVVTHNEFFDYD 232
Cdd:PRK01966  162 GLPVFVKPANLGSSVGISKVKNEEELAAALDLAFEYDRKVLVEQGIKGREIECAVLGNDPK--ASVPGEIVKPDDFYDYE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 233 AKYN-GQVDEITPARISDELTKRVQMLTSAIYDILGCSGIIRVDYIITAGEKLNLLEVNTTPGMTTTSFIPQQVRAAGLD 311
Cdd:PRK01966  240 AKYLdGSAELIIPADLSEELTEKIRELAIKAFKALGCSGLARVDFFLTEDGEIYLNEINTMPGFTPISMYPKLWEASGLS 319

                         330
                  ....*....|.
gi 1074127292 312 IKDVMTDIIEN 322
Cdd:PRK01966  320 YPELIDRLIEL 330
DdlA COG1181
D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, ...
 4-322 1.35e-122

D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, General function prediction only]; D-alanine-D-alanine ligase or related ATP-grasp enzyme is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440794 [Multi-domain]  Cd Length: 303  Bit Score: 353.64  E-value: 1.35e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292   4 NIAIVAGGDTSEIVVSLRSAQGIYSFIDKEKYNLYIVEmegrrwevqlpdgnkvpVDRNDFSFTNGTEKvvFDFAYITIH 83
Cdd:COG1181     2 RVAVLFGGRSAEREVSLKSGRAVAAALDKAGYDVVPIG-----------------IDVEDLPAALKELK--PDVVFPALH 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292  84 GTPGEDGRLQGYFDMMRIPYSCCGVLAAAITYDKFTCNQYLKAFGVRIAESLLLRQGQSVSDEEVVEKIGLPCFIKPSLG 163
Cdd:COG1181    63 GRGGEDGTIQGLLELLGIPYTGSGVLASALAMDKALTKRVLAAAGLPTPPYVVLRRGELADLEAIEEELGLPLFVKPARE 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 164 GSSFGVTKVKTKEQIQPAIVKAFGEAEEVIVEAFMDGTELTCGCYKTKEKsVIFPPTEVVTHNEFFDYDAKYN-GQVDEI 242
Cdd:COG1181   143 GSSVGVSKVKNAEELAAALEEAFKYDDKVLVEEFIDGREVTVGVLGNGGP-RALPPIEIVPENGFYDYEAKYTdGGTEYI 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 243 TPARISDELTKRVQMLTSAIYDILGCSGIIRVDYIITAGEKLNLLEVNTTPGMTTTSFIPQQVRAAGLDIKDVMTDIIEN 322
Cdd:COG1181   222 CPARLPEELEERIQELALKAFRALGCRGYARVDFRLDEDGEPYLLEVNTLPGMTPTSLLPKAAAAAGISYEELIERIIEL 301
D_ala_D_alaTIGR TIGR01205
D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a ...
 5-322 1.81e-89

D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a required precursor of the bacterial cell wall. It also describes some closely related proteins responsible for resistance to glycopeptide antibiotics such as vancomycin. The mechanism of glyopeptide antibiotic resistance involves the production of D-alanine-D-lactate (VanA and VanB families) or D-alanine-D-serine (VanC). The seed alignment contains only chromosomally encoded D-ala--D-ala ligases, but a number of antibiotic resistance proteins score above the trusted cutoff of this model. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273498 [Multi-domain]  Cd Length: 315  Bit Score: 269.92  E-value: 1.81e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292   5 IAIVAGGDTSEIVVSLRSAQGIYSFIDKEKYNLYIVEMEgrrwevqlPDGNKVPVDRNDFSFTNGTEKVVFDFAYITIHG 84
Cdd:TIGR01205   2 VAVLFGGKSAEHEISLVSAAAVLKALRDLGYDVYPVDID--------KMGSWTYKDLPQLILELGALLEGIDVVFPVLHG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292  85 TPGEDGRLQGYFDMMRIPYSCCGVLAAAITYDKFTCNQYLKAFGVRIAESLLLRQGQS----VSDEEVVEKIGLPCFIKP 160
Cdd:TIGR01205  74 RYGEDGTIQGLLELMGIPYTGSGVLASALSMDKLLTKLLWKALGLPTPDYIVLTQNRAsadeLECEQVAEPLGFPVIVKP 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 161 SLGGSSFGVTKVKTKEQIQPAIVKAFGEAEEVIVEAFMDGTELTCGCYKTKEKSVIFPPTEVVThnEFFDYDAKYN-GQV 239
Cdd:TIGR01205 154 AREGSSVGVSKVKSEEELQAALDEAFEYDEEVLVEQFIKGRELEVSILGNEEALPIIEIVPEIE--GFYDYEAKYLdGST 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 240 DEITPARISDELTKRVQMLTSAIYDILGCSGIIRVDYIITAGEKLNLLEVNTTPGMTTTSFIPQQVRAAGLDIKDVMTDI 319
Cdd:TIGR01205 232 EYVIPAPLDEELEEKIKELALKAYKALGCRGLARVDFFLDEEGEIYLNEINTIPGMTAISLFPKAAAAAGIEFSQLVERI 311


                  ...
gi 1074127292 320 IEN 322
Cdd:TIGR01205 312 LEL 314
Dala_Dala_lig_C pfam07478
D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the ...
 124-321 2.66e-51

D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF).


Pssm-ID: 429483 [Multi-domain]  Cd Length: 204  Bit Score: 168.65  E-value: 2.66e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 124 LKAFGVRIAESLLLRQGQSVSD-----EEVVEKIGLPCFIKPSLGGSSFGVTKVKTKEQIQPAIVKAFGEAEEVIVEAFM 198
Cdd:pfam07478   2 LKAAGLPVVPFVTFTRADWKLNpkewcAQVEEALGYPVFVKPARLGSSVGVSKVESREELQAAIEEAFQYDEKVLVEEGI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 199 DGTELTCGCYKTkEKSVIFPPTEVVTHNEFFDYDAKY-NGQVDEITPARISDELTKRVQMLTSAIYDILGCSGIIRVDYI 277
Cdd:pfam07478  82 EGREIECAVLGN-EDPEVSPVGEIVPSGGFYDYEAKYiDDSAQIVVPADLEEEQEEQIQELALKAYKALGCRGLARVDFF 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1074127292 278 ITAGEKLNLLEVNTTPGMTTTSFIPQQVRAAGLDIKDVMTDIIE 321
Cdd:pfam07478 161 LTEDGEIVLNEVNTIPGFTSISMFPKLAAAAGVSFPDLVDQLIE 204
 
Name Accession Description Interval E-value
ddl PRK01966
D-alanine--D-alanine ligase;
1-322 3.10e-136

D-alanine--D-alanine ligase;


Pssm-ID: 234993 [Multi-domain]  Cd Length: 333  Bit Score: 389.48  E-value: 3.10e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292   1 MKRNIAIVAGGDTSEIVVSLRSAQGIYSFIDKEKYNLYIVEM-EGRRWEVQLPDGNKVP---VDRNDFSFTNGTEKVV-- 74
Cdd:PRK01966    2 MKMRVALLFGGRSAEHEVSLVSAKSVLKALDKEKYEVVPIGItKDGRWYLIDADNMELAdddNDKEDLSLLILPSGGSee 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292  75 FDFAYITIHGTPGEDGRLQGYFDMMRIPYSCCGVLAAAITYDKFTCNQYLKAFGVRIAESLLLRQGQ--SVSDEEVVEKI 152
Cdd:PRK01966   82 VDVVFPVLHGPPGEDGTIQGLLELLGIPYVGCGVLASALSMDKILTKRLLAAAGIPVAPYVVLTRGDweEASLAEIEAKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 153 GLPCFIKPSLGGSSFGVTKVKTKEQIQPAIVKAFGEAEEVIVEAFMDGTELTCGCYKTKEKsvIFPPTEVVTHNEFFDYD 232
Cdd:PRK01966  162 GLPVFVKPANLGSSVGISKVKNEEELAAALDLAFEYDRKVLVEQGIKGREIECAVLGNDPK--ASVPGEIVKPDDFYDYE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 233 AKYN-GQVDEITPARISDELTKRVQMLTSAIYDILGCSGIIRVDYIITAGEKLNLLEVNTTPGMTTTSFIPQQVRAAGLD 311
Cdd:PRK01966  240 AKYLdGSAELIIPADLSEELTEKIRELAIKAFKALGCSGLARVDFFLTEDGEIYLNEINTMPGFTPISMYPKLWEASGLS 319

                         330
                  ....*....|.
gi 1074127292 312 IKDVMTDIIEN 322
Cdd:PRK01966  320 YPELIDRLIEL 330
DdlA COG1181
D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, ...
 4-322 1.35e-122

D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, General function prediction only]; D-alanine-D-alanine ligase or related ATP-grasp enzyme is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440794 [Multi-domain]  Cd Length: 303  Bit Score: 353.64  E-value: 1.35e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292   4 NIAIVAGGDTSEIVVSLRSAQGIYSFIDKEKYNLYIVEmegrrwevqlpdgnkvpVDRNDFSFTNGTEKvvFDFAYITIH 83
Cdd:COG1181     2 RVAVLFGGRSAEREVSLKSGRAVAAALDKAGYDVVPIG-----------------IDVEDLPAALKELK--PDVVFPALH 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292  84 GTPGEDGRLQGYFDMMRIPYSCCGVLAAAITYDKFTCNQYLKAFGVRIAESLLLRQGQSVSDEEVVEKIGLPCFIKPSLG 163
Cdd:COG1181    63 GRGGEDGTIQGLLELLGIPYTGSGVLASALAMDKALTKRVLAAAGLPTPPYVVLRRGELADLEAIEEELGLPLFVKPARE 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 164 GSSFGVTKVKTKEQIQPAIVKAFGEAEEVIVEAFMDGTELTCGCYKTKEKsVIFPPTEVVTHNEFFDYDAKYN-GQVDEI 242
Cdd:COG1181   143 GSSVGVSKVKNAEELAAALEEAFKYDDKVLVEEFIDGREVTVGVLGNGGP-RALPPIEIVPENGFYDYEAKYTdGGTEYI 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 243 TPARISDELTKRVQMLTSAIYDILGCSGIIRVDYIITAGEKLNLLEVNTTPGMTTTSFIPQQVRAAGLDIKDVMTDIIEN 322
Cdd:COG1181   222 CPARLPEELEERIQELALKAFRALGCRGYARVDFRLDEDGEPYLLEVNTLPGMTPTSLLPKAAAAAGISYEELIERIIEL 301
ddl PRK01372
D-alanine--D-alanine ligase; Reviewed
 1-321 6.35e-93

D-alanine--D-alanine ligase; Reviewed


Pssm-ID: 234948 [Multi-domain]  Cd Length: 304  Bit Score: 278.53  E-value: 6.35e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292   1 MKRNIAIVAGGDTSEIVVSLRSAQGIYSFIDKEKYNLYIVEMeGRRWEVQLpdgnkvpvdrndfsftngtEKVVFDFAYI 80
Cdd:PRK01372    3 MFGKVAVLMGGTSAEREVSLNSGAAVLAALREAGYDAHPIDP-GEDIAAQL-------------------KELGFDRVFN 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292  81 TIHGTPGEDGRLQGYFDMMRIPYSCCGVLAAAITYDKFTCNQYLKAFGVRIAESLLLRQGQSvsDEEVVEKIGLPCFIKP 160
Cdd:PRK01372   63 ALHGRGGEDGTIQGLLELLGIPYTGSGVLASALAMDKLRTKLVWQAAGLPTPPWIVLTREED--LLAAIDKLGLPLVVKP 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 161 SLGGSSFGVTKVKTKEQIQPAIVKAFGEAEEVIVEAFMDGTELTCGCYKTKeksvIFPPTEVVTHNEFFDYDAKY-NGQV 239
Cdd:PRK01372  141 AREGSSVGVSKVKEEDELQAALELAFKYDDEVLVEKYIKGRELTVAVLGGK----ALPVIEIVPAGEFYDYEAKYlAGGT 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 240 DEITPARISDELTKRVQMLTSAIYDILGCSGIIRVDYIITAGEKLNLLEVNTTPGMTTTSFIPQQVRAAGLDIKDVMTDI 319
Cdd:PRK01372  217 QYICPAGLPAEIEAELQELALKAYRALGCRGWGRVDFMLDEDGKPYLLEVNTQPGMTSHSLVPMAARAAGISFSELVDRI 296


                  ..
gi 1074127292 320 IE 321
Cdd:PRK01372  297 LE 298
D_ala_D_alaTIGR TIGR01205
D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a ...
 5-322 1.81e-89

D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a required precursor of the bacterial cell wall. It also describes some closely related proteins responsible for resistance to glycopeptide antibiotics such as vancomycin. The mechanism of glyopeptide antibiotic resistance involves the production of D-alanine-D-lactate (VanA and VanB families) or D-alanine-D-serine (VanC). The seed alignment contains only chromosomally encoded D-ala--D-ala ligases, but a number of antibiotic resistance proteins score above the trusted cutoff of this model. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273498 [Multi-domain]  Cd Length: 315  Bit Score: 269.92  E-value: 1.81e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292   5 IAIVAGGDTSEIVVSLRSAQGIYSFIDKEKYNLYIVEMEgrrwevqlPDGNKVPVDRNDFSFTNGTEKVVFDFAYITIHG 84
Cdd:TIGR01205   2 VAVLFGGKSAEHEISLVSAAAVLKALRDLGYDVYPVDID--------KMGSWTYKDLPQLILELGALLEGIDVVFPVLHG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292  85 TPGEDGRLQGYFDMMRIPYSCCGVLAAAITYDKFTCNQYLKAFGVRIAESLLLRQGQS----VSDEEVVEKIGLPCFIKP 160
Cdd:TIGR01205  74 RYGEDGTIQGLLELMGIPYTGSGVLASALSMDKLLTKLLWKALGLPTPDYIVLTQNRAsadeLECEQVAEPLGFPVIVKP 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 161 SLGGSSFGVTKVKTKEQIQPAIVKAFGEAEEVIVEAFMDGTELTCGCYKTKEKSVIFPPTEVVThnEFFDYDAKYN-GQV 239
Cdd:TIGR01205 154 AREGSSVGVSKVKSEEELQAALDEAFEYDEEVLVEQFIKGRELEVSILGNEEALPIIEIVPEIE--GFYDYEAKYLdGST 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 240 DEITPARISDELTKRVQMLTSAIYDILGCSGIIRVDYIITAGEKLNLLEVNTTPGMTTTSFIPQQVRAAGLDIKDVMTDI 319
Cdd:TIGR01205 232 EYVIPAPLDEELEEKIKELALKAYKALGCRGLARVDFFLDEEGEIYLNEINTIPGMTAISLFPKAAAAAGIEFSQLVERI 311


                  ...
gi 1074127292 320 IEN 322
Cdd:TIGR01205 312 LEL 314
PRK14572 PRK14572
D-alanyl-alanine synthetase A; Provisional
 2-321 2.40e-78

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 173036 [Multi-domain]  Cd Length: 347  Bit Score: 242.89  E-value: 2.40e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292   2 KRNIAIVAGGDTSEIVVSLRSAQGIYSFIDKEKYNL--YIVEMEGRRW-----EVQLPD--GNKVPVDRNDFSFTNGTEK 72
Cdd:PRK14572    1 MAKIAVFFGGSSTEHSISIRTGCFICATLHTMGHSVkpILLTPDGGWVvptvyRPSIPDesGNSEDLFLEEFQKANGVSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292  73 VV------FDFAYITIHGTPGEDGRLQGYFDMMRIPYSCCGVLAAAITYDKFTCNQYLKAFGVRIAESLLLRQGQSVSDE 146
Cdd:PRK14572   81 PAdisqldADIAFLGLHGGAGEDGRIQGFLDTLGIPYTGSGVLASALAMDKTRANQIFLQSGQKVAPFFELEKLKYLNSP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 147 EVV----EKIGLPCFIKPSLGGSSFGVTKVKTKEQIQPAIVKAFGEAEEVIVEAFMDGTELTCGCYKT----KEKSVIFP 218
Cdd:PRK14572  161 RKTllklESLGFPQFLKPVEGGSSVSTYKITNAEQLMTLLALIFESDSKVMSQSFLSGTEVSCGVLERyrggKRNPIALP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 219 PTEVVTHNEFFDYDAKY-NGQVDEITPARISDELTKRVQMLTSAIYDILGCSGIIRVDYIITAGEKlNLLEVNTTPGMTT 297
Cdd:PRK14572  241 ATEIVPGGEFFDFESKYkQGGSEEITPARISDQEMKRVQELAIRAHESLGCKGYSRTDFIIVDGEP-HILETNTLPGMTE 319

                         330       340
                  ....*....|....*....|....
gi 1074127292 298 TSFIPQQVRAAGLDIKDVMTDIIE 321
Cdd:PRK14572  320 TSLIPQQAKAAGINMEEVFTDLIE 343
Dala_Dala_lig_C pfam07478
D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the ...
 124-321 2.66e-51

D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF).


Pssm-ID: 429483 [Multi-domain]  Cd Length: 204  Bit Score: 168.65  E-value: 2.66e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 124 LKAFGVRIAESLLLRQGQSVSD-----EEVVEKIGLPCFIKPSLGGSSFGVTKVKTKEQIQPAIVKAFGEAEEVIVEAFM 198
Cdd:pfam07478   2 LKAAGLPVVPFVTFTRADWKLNpkewcAQVEEALGYPVFVKPARLGSSVGVSKVESREELQAAIEEAFQYDEKVLVEEGI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 199 DGTELTCGCYKTkEKSVIFPPTEVVTHNEFFDYDAKY-NGQVDEITPARISDELTKRVQMLTSAIYDILGCSGIIRVDYI 277
Cdd:pfam07478  82 EGREIECAVLGN-EDPEVSPVGEIVPSGGFYDYEAKYiDDSAQIVVPADLEEEQEEQIQELALKAYKALGCRGLARVDFF 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1074127292 278 ITAGEKLNLLEVNTTPGMTTTSFIPQQVRAAGLDIKDVMTDIIE 321
Cdd:pfam07478 161 LTEDGEIVLNEVNTIPGFTSISMFPKLAAAAGVSFPDLVDQLIE 204
PRK14571 PRK14571
D-alanyl-alanine synthetase A; Provisional
 5-324 6.53e-47

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 184751 [Multi-domain]  Cd Length: 299  Bit Score: 160.37  E-value: 6.53e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292   5 IAIVAGGDTSEIVVSLRSAQGIYSFIDKEKYNLyivemegrrwevqlpdgnkVPVDRNDFSFTNGTEKVVFDFAYITIHG 84
Cdd:PRK14571    3 VALLMGGVSREREISLRSGERVKKALEKLGYEV-------------------TVFDVDEDFLKKVDQLKSFDVVFNVLHG 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292  85 TPGEDGRLQGYFDMMRIPYSCCGVLAAAITYDKFTCNQYLKAFgVRIAESLLLRQGQSVSdeevveKIGLPCFIKPSLGG 164
Cdd:PRK14571   64 TFGEDGTLQAILDFLGIRYTGSDAFSSMICFDKLLTYRFLKGT-VEIPDFVEIKEFMKTS------PLGYPCVVKPRREG 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 165 SSFGVTKVKTKEQIQPAIVKAFGEAEEVIVEAFMDGTELTCGCYKTKEKSVIFPPTEVVTHNEFFDYDAKY-NGQVDEIT 243
Cdd:PRK14571  137 SSIGVFICESDEEFQHALKEDLPRYGSVIVQEYIPGREMTVSILETEKGFEVLPILELRPKRRFYDYVAKYtKGETEFIL 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 244 PARISDELTKRVQMLTSAIYDILGCSGIIRVDYIITAGEkLNLLEVNTTPGMTTTSFIPQQVRAAGLDIKDVMTDIIENK 323
Cdd:PRK14571  217 PAPLNPEEERLVKETALKAFVEAGCRGFGRVDGIFSDGR-FYFLEINTVPGLTELSDLPASAKAGGIEFEELVDIIIKSA 295


                  .
gi 1074127292 324 F 324
Cdd:PRK14571  296 F 296
PRK14570 PRK14570
D-alanyl-alanine synthetase A; Provisional
 1-324 6.67e-40

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 173034 [Multi-domain]  Cd Length: 364  Bit Score: 143.43  E-value: 6.67e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292   1 MKRNIAIVAGGDTSEIVVSLRSAQGIYS-FIDKEKYNLYIVEMEGRR--WEV--QLPDGNKvPVDRNDFSFTN------- 68
Cdd:PRK14570    1 MKKNLMLIFGGVSFEHEISLRSAYGIYSaLLKLDKYNIYSVFIDKCTgiWYLldSVPDPPK-LIKRDVLPIVSlipgcgi 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292  69 --GTEKVVFDFAYITIHGTPGEDGRLQGYFDMMRIPYSCCGVLAAAITYDKFTCNQYLKAFGVRIAESLLLRQGQSVSDE 146
Cdd:PRK14570   80 fvNNKNLEIDVVFPIVHGRTGEDGAIQGFLKVMDIPCVGAGILGSAISINKYFCKLLLKSFNIPLVPFIGFRKYDYFLDK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 147 E-----VVEKIGLPCFIKPSLGGSSFGVTKVKTKEQIQPAIVKAFGEAEEVIVEAFMDGTELTCGCYKTkEKSVIFPPTE 221
Cdd:PRK14570  160 EgikkdIKEVLGYPVIVKPAVLGSSIGINVAYNENQIEKCIEEAFKYDLTVVIEKFIEAREIECSVIGN-EQIKIFTPGE 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 222 VVTHN-EFFDYDAKY-----NGQVDEItPARISDELTKRVQMLTSAIYDILGCSGIIRVDYIITA-GEKLNLLEVNTTPG 294
Cdd:PRK14570  239 IVVQDfIFYDYDAKYstipgNSIVFNI-PAHLDTKHLLDIKEYAFLTYKNLELRGMARIDFLIEKdTGLIYLNEINTIPG 317

                         330       340       350
                  ....*....|....*....|....*....|
gi 1074127292 295 MTTTSFIPQQVRAAGLDIKDVMTDIIENKF 324
Cdd:PRK14570  318 FTDISMFAKMCEHDGLQYKSLVDNLIDLAF 347
PRK14569 PRK14569
D-alanyl-alanine synthetase A; Provisional
 2-321 8.01e-38

D-alanyl-alanine synthetase A; Provisional


Pssm-ID: 173033 [Multi-domain]  Cd Length: 296  Bit Score: 136.34  E-value: 8.01e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292   2 KRNIAIVAGGDTSEIVVSLRSAQGIYSFIDKEKYNLYIVEMEGRRWEVQLPDGNKvpvdrndfsftngtekvvfDFAYIT 81
Cdd:PRK14569    3 NEKIVVLYGGDSPEREVSLKSGKAVLDSLISQGYDAVGVDASGKELVAKLLELKP-------------------DKCFVA 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292  82 IHGTPGEDGRLQGYFDMMRIPYSCCGVLAAAITYDKFTCNQYLKAFGVRIAESLLLRQGQSVSDEevvekIGLPCFIKPS 161
Cdd:PRK14569   64 LHGEDGENGRVSALLEMLEIKHTSSSMKSSVITMDKMISKEILMHHRMPTPMAKFLTDKLVAEDE-----ISFPVAVKPS 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 162 LGGSSFGVTKVKTKEQIQPAIVKAfGEAEEVIVEAFMDGTELTCGCYKTKEKSVIFppteVVTHNEFFDYDAKYNGQVDE 241
Cdd:PRK14569  139 SGGSSIATFKVKSIQELKHAYEEA-SKYGEVMIEQWVTGKEITVAIVNDEVYSSVW----IEPQNEFYDYESKYSGKSIY 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 242 ITPARISDELTKRVQMLTSAIYDILGCSGIIRVDYIITAGEKLNLLEVNTTPGMTTTSFIPQQVRAAGLDIKDVMTDIIE 321
Cdd:PRK14569  214 HSPSGLCEQKELEVRQLAKKAYDLLGCSGHARVDFIYDDRGNFYIMEINSSPGMTDNSLSPKSAAAEGVDFDSFVKRIIE 293
PRK14573 PRK14573
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
2-307 7.09e-29

bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;


Pssm-ID: 184752 [Multi-domain]  Cd Length: 809  Bit Score: 116.84  E-value: 7.09e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292   2 KRNIAIVAGGDTSEIVVSLRSAQGIYSFIDKEKYNL--YIVEMEGRrWEvqlpdgnkvPVDRNDFSFTNGTEKVVF---- 75
Cdd:PRK14573  451 KLSLGLVCGGKSCEHDISLLSAKNIAKYLSPEFYDVsyFLINRQGL-WE---------TVSSLETAIEEDSGKSVLssei 520

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292  76 -------DFAYITIHGTPGEDGRLQGYFDMMRIPYSCCGVLAAAITYDKFTCNQYLKAFGVRIAESLLL-----RQGQSV 143
Cdd:PRK14573  521 aqalakvDVVLPILHGPFGEDGTMQGFLEIIGKPYTGPSLAFSAIAMDKVLTKRFASDVGVPVVPYQPLtlagwKREPEL 600

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 144 SDEEVVEKIGLPCFIKPSLGGSSFGVTKVKTKEQIQPAIVKAFGEAEEVIVEAFMDGT---ELTC-----GCYktkeksV 215
Cdd:PRK14573  601 CLAHIVEAFSFPMFVKTAHLGSSIGVFEVHNVEELRDKISEAFLYDTDVFVEESRLGSreiEVSClgdgsSAY------V 674

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 216 IFPPTEVVTHNEFFDYDAKYNgqVDEITPARI------SDELTKRVQMLTSAIYDILGCSGIIRVDYIITAGEKLNLLEV 289
Cdd:PRK14573  675 IAGPHERRGSGGFIDYQEKYG--LSGKSSAQIvfdldlSKESQEQVLELAERIYRLLQGKGSCRIDFFLDEEGNFWLSEM 752

                         330
                  ....*....|....*....
gi 1074127292 290 NTTPGMTTTS-FIPQQVRA 307
Cdd:PRK14573  753 NPIPGMTEASpFLTAFVRK 771
Dala_Dala_lig_N pfam01820
D-ala D-ala ligase N-terminus; This family represents the N-terminal region of the ...
 4-103 3.88e-22

D-ala D-ala ligase N-terminus; This family represents the N-terminal region of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4 which is thought to be involved in substrate binding. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF). This domain is structurally related to the PreATP-grasp domain.


Pssm-ID: 460346 [Multi-domain]  Cd Length: 118  Bit Score: 89.59  E-value: 3.88e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292   4 NIAIVAGGDTSEIVVSLRSAQGIYSFIDKEKYN---LYI------------VEMEGRRWEVQLPDGNKVPVDRNDFSFTN 68
Cdd:pfam01820   1 KVAVLFGGRSSEHEVSLVSARSVLKALDKEKYEvipIGItkdgrlgeaalrELASDDGLLLEVDDAPDGGPAGLLFGPNV 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1074127292  69 GTEKVVFDFAYITIHGTPGEDGRLQGYFDMMRIPY 103
Cdd:pfam01820  81 LELLIEVDVVFPVLHGPNGEDGTLQGLLELAGIPY 115
AccC COG0439
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ...
 110-312 1.28e-18

Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440208 [Multi-domain]  Cd Length: 263  Bit Score: 83.77  E-value: 1.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 110 AAAITYDKFTCNQYLKAFGVRIAESLLLRqgqSVSD-EEVVEKIGLPCFIKPSLGGSSFGVTKVKTKEQIQPAIVKAFGE 188
Cdd:COG0439    48 AIRAMRDKVLMREALAAAGVPVPGFALVD---SPEEaLAFAEEIGYPVVVKPADGAGSRGVRVVRDEEELEAALAEARAE 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 189 A------EEVIVEAFMDGTELTCGCYKTKEKSVIFPPTEVVTHNEFFdydakynGQVDEITPARISDELTKRVQMLTSAI 262
Cdd:COG0439   125 AkagspnGEVLVEEFLEGREYSVEGLVRDGEVVVCSITRKHQKPPYF-------VELGHEAPSPLPEELRAEIGELVARA 197

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1074127292 263 YDILG-CSGIIRVDYIITAGEKLNLLEVNT-TPGmtttSFIPQQVRAA-GLDI 312
Cdd:COG0439   198 LRALGyRRGAFHTEFLLTPDGEPYLIEINArLGG----EHIPPLTELAtGVDL 246
PRK12767 PRK12767
carbamoyl phosphate synthase-like protein; Provisional
 113-216 5.19e-15

carbamoyl phosphate synthase-like protein; Provisional


Pssm-ID: 237195 [Multi-domain]  Cd Length: 326  Bit Score: 74.54  E-value: 5.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 113 ITYDKFTCNQYLKAFGVRIAESLLLRQGQSVSDEEVVEKIGLPCFIKPSLGGSSFGVTKVKTKEQIQPaivkAFGEAEEV 192
Cdd:PRK12767  108 ICNDKWLTYEFLKENGIPTPKSYLPESLEDFKAALAKGELQFPLFVKPRDGSASIGVFKVNDKEELEF----LLEYVPNL 183

                          90       100
                  ....*....|....*....|....
gi 1074127292 193 IVEAFMDGTELTCGCYKTKEKSVI 216
Cdd:PRK12767  184 IIQEFIEGQEYTVDVLCDLNGEVI 207
PurK COG0026
Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and ...
 112-284 1.05e-08

Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439797 [Multi-domain]  Cd Length: 353  Bit Score: 55.85  E-value: 1.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 112 AITYDKFTCNQYLKAFGVRIAESLLLRqgqSVSD-EEVVEKIGLPCFIKPSLGGss-fGVTKVKTKEQIQPAiVKAFGEA 189
Cdd:COG0026    85 EIAQDRLLEKAFLAELGIPVAPFAAVD---SLEDlEAAIAELGLPAVLKTRRGGydgkGQVVIKSAADLEAA-WAALGGG 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 190 EeVIVEAFMDgteltcgcYKtKEKSVI-----------FPPTEvvthNEFfdydakYNGQVDE-ITPARISDELTKRVQM 257
Cdd:COG0026   161 P-CILEEFVP--------FE-RELSVIvarspdgevatYPVVE----NVH------RNGILDEsIAPARISEALAAEAEE 220

                         170       180
                  ....*....|....*....|....*..
gi 1074127292 258 LTSAIYDILGCSGIIRVDYIITAGEKL 284
Cdd:COG0026   221 IAKRIAEALDYVGVLAVEFFVTKDGEL 247
PurT COG0027
Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide ...
 146-204 2.47e-08

Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439798 [Multi-domain]  Cd Length: 393  Bit Score: 54.75  E-value: 2.47e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1074127292 146 EEVVEKIGLPCFIKPSLGGSSFGVTKVKTKEQIQP----AIVKAFGEAEEVIVEAFMD-GTELT 204
Cdd:COG0027   142 RAAVEEIGYPCVVKPVMSSSGKGQSVVRSPADIEAaweyAQEGGRGGAGRVIVEGFVDfDYEIT 205
purT PRK09288
formate-dependent phosphoribosylglycinamide formyltransferase;
146-316 2.51e-08

formate-dependent phosphoribosylglycinamide formyltransferase;


Pssm-ID: 236454 [Multi-domain]  Cd Length: 395  Bit Score: 54.76  E-value: 2.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 146 EEVVEKIGLPCFIKPSLGGSSFGVTKVKTKEQIQP----AIVKAFGEAEEVIVEAFMDG----TELTcgcYKTKEKSVIF 217
Cdd:PRK09288  142 RAAVEEIGYPCVVKPVMSSSGKGQSVVRSPEDIEKaweyAQEGGRGGAGRVIVEEFIDFdyeiTLLT---VRAVDGGTHF 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 218 -PPtevVTHnefFDYDAKYngqVDEITPARISDELTKRVQMLTSAIYDILGCSGIIRVDYIITaGEKLNLLEVNTTP--- 293
Cdd:PRK09288  219 cAP---IGH---RQEDGDY---RESWQPQPMSPAALEEAQEIAKKVTDALGGRGLFGVELFVK-GDEVYFSEVSPRPhdt 288

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1074127292 294 GMTTtsFIPQ-------QVRAA-GLDIKDVM 316
Cdd:PRK09288  289 GMVT--LISQnlsefelHARAIlGLPIPDIR 317
PRK14016 PRK14016
cyanophycin synthetase; Provisional
 109-202 1.24e-07

cyanophycin synthetase; Provisional


Pssm-ID: 237586 [Multi-domain]  Cd Length: 727  Bit Score: 53.24  E-value: 1.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 109 LAAAITYDKFTCNQYLKAFGVRIAEslllrqGQSVSDEE----VVEKIGLPCFIKPSLGGSSFGVT-KVKTKEQIQPAIV 183
Cdd:PRK14016  207 IAVDIACDKELTKRLLAAAGVPVPE------GRVVTSAEdaweAAEEIGYPVVVKPLDGNHGRGVTvNITTREEIEAAYA 280

                          90
                  ....*....|....*....
gi 1074127292 184 KAFGEAEEVIVEAFMDGTE 202
Cdd:PRK14016  281 VASKESSDVIVERYIPGKD 299
ATP-grasp_4 pfam13535
ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent ...
 152-267 2.87e-07

ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.


Pssm-ID: 316093 [Multi-domain]  Cd Length: 160  Bit Score: 49.59  E-value: 2.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 152 IGLPCFIKPSLGGSSFGVTKVKTKEQIQPAIV--------------KAFGEAEEVIVEAFMDGTELTCGCYKTKE-KSVI 216
Cdd:pfam13535   1 IPYPCVIKPSVGFFSVGVYKINNREEWKAAFAaireeieqwkemypEAVVDGGSFLVEEYIEGEEFAVDAYFDENgEPVI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1074127292 217 FppteVVTHNEFfdYDAKYNGQVDEITPARISDELTKRVQMLTSAIYDILG 267
Cdd:pfam13535  81 L----NILKHDF--ASSEDVSDRIYVTSASIIRETQAAFTEFLKRINALLG 125
ATP-grasp_3 pfam02655
ATP-grasp domain; No functional information or experimental verification of function is known ...
 116-298 4.12e-06

ATP-grasp domain; No functional information or experimental verification of function is known in this family. This family appears to be an ATP-grasp domain (Pers. obs. A Bateman).


Pssm-ID: 396979 [Multi-domain]  Cd Length: 160  Bit Score: 46.22  E-value: 4.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 116 DKFTCNQYLKAFGVRIAESLllrqgqsvSDEEVVEkIGLPCFIKPSLGGSSFGVTKVKTKEQIQPAIvkafgeaEEVIVE 195
Cdd:pfam02655   3 DKLKTYKALKNAGVPTPETL--------QAEELLR-EEKKYVVKPRDGCGGEGVRKVENGREDEAFI-------ENVLVQ 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 196 AFMDGTELTCGCYKTKEKSVIFPPTEVVTHNEFFDYdaKYNGqvdEITPARisDELTKRVQMLTS-AIYDILGCSGIIRV 274
Cdd:pfam02655  67 EFIEGEPLSVSLLSDGEKALPLSVNRQYIDNGGSGF--VYAG---NVTPSR--TELKEEIIELAEeVVECLPGLRGYVGV 139

                         170       180
                  ....*....|....*....|....
gi 1074127292 275 DYIITAGEkLNLLEVNttPGMTTT 298
Cdd:pfam02655 140 DLVLKDNE-PYVIEVN--PRITTS 160
PRK06019 PRK06019
phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed
 112-284 3.25e-05

phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed


Pssm-ID: 235674 [Multi-domain]  Cd Length: 372  Bit Score: 45.14  E-value: 3.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 112 AITYDKFTCNQYLKAFGVRIAESLLLrqgQSVSD-EEVVEKIGLPCFIKPSLGGssF---GVTKVKTKEQIQpAIVKAFG 187
Cdd:PRK06019   96 AIAQDRLTEKQFLDKLGIPVAPFAVV---DSAEDlEAALADLGLPAVLKTRRGG--YdgkGQWVIRSAEDLE-AAWALLG 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1074127292 188 eAEEVIVEAFMDgteltcgcYKtKEKSVI-----------FPPTEvvTHNEffdydakyNGQVDE-ITPARISDELTKRV 255
Cdd:PRK06019  170 -SVPCILEEFVP--------FE-REVSVIvargrdgevvfYPLVE--NVHR--------NGILRTsIAPARISAELQAQA 229

                         170       180
                  ....*....|....*....|....*....
gi 1074127292 256 QMLTSAIYDILGCSGIIRVDYIITAGEKL 284
Cdd:PRK06019  230 EEIASRIAEELDYVGVLAVEFFVTGDGEL 258
PRK08654 PRK08654
acetyl-CoA carboxylase biotin carboxylase subunit;
147-201 5.52e-03

acetyl-CoA carboxylase biotin carboxylase subunit;


Pssm-ID: 236325 [Multi-domain]  Cd Length: 499  Bit Score: 38.43  E-value: 5.52e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1074127292 147 EVVEKIGLPCFIKPSLGGSSFGVTKVKTKEQIQPAIVKAFGEAEevivEAFMDGT 201
Cdd:PRK08654  146 EIAEEIGYPVIIKASAGGGGIGMRVVYSEEELEDAIESTQSIAQ----SAFGDST 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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