NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1072982768|ref|XP_018441887|]
View 

phosphoinositide phosphatase SAC2 isoform X1 [Raphanus sativus]

Protein Classification

SAC family polyphosphoinositide phosphatase( domain architecture ID 10493136)

SAC family polyphosphoinositide phosphatase catalyzes the hydrolysis of phosphatidylinositol (PtdIns) phosphates, such as PtdIns(3)P, PtdIns(4)P, and/or PtdIns(3,5)P2

EC:  3.1.3.-
Gene Ontology:  GO:0046856|GO:0052866
PubMed:  10947947

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Syja_N pfam02383
SacI homology domain; This Pfam family represents a protein domain which shows homology to the ...
95-393 1.41e-121

SacI homology domain; This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.


:

Pssm-ID: 460545  Cd Length: 295  Bit Score: 366.90  E-value: 1.41e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072982768  95 YGIIGFIRFLGPYYMLIITKRRKLGEVCGHTVYGVAKSRIVTIPHAS--VLSNVAYSKDEKRYKRLLCSVDLTKDFFFSY 172
Cdd:pfam02383   1 YGILGLIRLLSGYYLIVITKREQVGQIGGHPIYKITDVEFIPLNSSLsdTQLAKKEHPDEERLLKLLKLFLSSGSFYFSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072982768 173 SYHIMHSLQRNLTNNAEGHIYYESM-FVWNEYLTRRIRNSTKD-CMWTVALVYGFFKQVKLSVSEKNFRLTLIARRSRHY 250
Cdd:pfam02383  81 DYDLTNSLQRNLTRSRSPSFDSLDDrFFWNRHLLKPLIDFQLDlDRWILPLIQGFVEQGKLSVFGRSVTLTLISRRSRKR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072982768 251 AGTRYLKRGVNEKGRVANDVETEQIVYEDAQDGHPvRISSVVQNRGSIPLFWSQDTSrLNIKPDIILSGKDPNFEATRLH 330
Cdd:pfam02383 161 AGTRYLRRGIDDDGNVANFVETEQIVSLNTSNSEG-KIFSFVQIRGSIPLFWSQDPN-LKYKPKIQITRPEATQPAFKKH 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1072982768 331 FENLARRYGnPIIVLNLIktrEKRPRETILRVEFANAIKFINKGLSKeeRLRPLHWDLHKHSR 393
Cdd:pfam02383 239 FDDLIERYG-PVHIVNLV---EKKGRESKLSEAYEEAVKYLNQFLPD--KLRYTAFDFHHECK 295
 
Name Accession Description Interval E-value
Syja_N pfam02383
SacI homology domain; This Pfam family represents a protein domain which shows homology to the ...
95-393 1.41e-121

SacI homology domain; This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.


Pssm-ID: 460545  Cd Length: 295  Bit Score: 366.90  E-value: 1.41e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072982768  95 YGIIGFIRFLGPYYMLIITKRRKLGEVCGHTVYGVAKSRIVTIPHAS--VLSNVAYSKDEKRYKRLLCSVDLTKDFFFSY 172
Cdd:pfam02383   1 YGILGLIRLLSGYYLIVITKREQVGQIGGHPIYKITDVEFIPLNSSLsdTQLAKKEHPDEERLLKLLKLFLSSGSFYFSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072982768 173 SYHIMHSLQRNLTNNAEGHIYYESM-FVWNEYLTRRIRNSTKD-CMWTVALVYGFFKQVKLSVSEKNFRLTLIARRSRHY 250
Cdd:pfam02383  81 DYDLTNSLQRNLTRSRSPSFDSLDDrFFWNRHLLKPLIDFQLDlDRWILPLIQGFVEQGKLSVFGRSVTLTLISRRSRKR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072982768 251 AGTRYLKRGVNEKGRVANDVETEQIVYEDAQDGHPvRISSVVQNRGSIPLFWSQDTSrLNIKPDIILSGKDPNFEATRLH 330
Cdd:pfam02383 161 AGTRYLRRGIDDDGNVANFVETEQIVSLNTSNSEG-KIFSFVQIRGSIPLFWSQDPN-LKYKPKIQITRPEATQPAFKKH 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1072982768 331 FENLARRYGnPIIVLNLIktrEKRPRETILRVEFANAIKFINKGLSKeeRLRPLHWDLHKHSR 393
Cdd:pfam02383 239 FDDLIERYG-PVHIVNLV---EKKGRESKLSEAYEEAVKYLNQFLPD--KLRYTAFDFHHECK 295
COG5329 COG5329
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
95-580 1.28e-84

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 279.66  E-value: 1.28e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072982768  95 YGIIGFIRFLGPYYMLIITKRRKLGEVCGHTVYGVAKSRIVTIphasvlsNVAYSKDEK-----RYKRLLCSVDLTKD-- 167
Cdd:COG5329    61 YGVIGLIKLKGDIYLIVITGASLVGVIPGHSIYKILDVDFISL-------NNNKWDDELeedeaNYDKLSELKKLLSNgt 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072982768 168 FFFSYSYHIMHSLQRNL-TNNAEGHIYYESMFVWNEYLTRRIRN--------STKDCMWTVALVYGFFKQVKLSVSEKNF 238
Cdd:COG5329   134 FYFSYDFDITNSLQKNLsEGLEASVDRADLIFMWNSFLLEEFINhrsklsslEKQFDNFLTTVIRGFAETVDIKVGGNTI 213
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072982768 239 RLTLIARRSRHYAGTRYLKRGVNEKGRVANDVETEQIVYeDAQdghpvRISSVVQNRGSIPLFWSQDTSRlnIKPDIILS 318
Cdd:COG5329   214 SLTLISRRSSERAGTRYLSRGIDDDGNVSNFVETEQIVT-DSQ-----YIFSFTQVRGSIPLFWEQSNLL--YGPKIKVT 285
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072982768 319 GKDPNFE-ATRLHFENLARRYGnPIIVLNLIKTREkrpRETILRVEFANAIKfinkgLSKEERLRPLHWDLHKHSRKKGt 397
Cdd:COG5329   286 RSSEAAQsAFDKHFDKLREKYG-DVYVVNLLKTKG---YEAPLLELYEKHLD-----LSKKPKIHYTEFDFHKETSQDG- 355
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072982768 398 nvLAILGRLATYALNLtgvfycqLTPDGFQNNAGecsttdeiasdslvekNGNDTTVLQKGVLRTNCIDCLDRTNVAQYA 477
Cdd:COG5329   356 --FDDVKKLLYLIEQD-------LLEFGYFAYDI----------------NEGKSISEQDGVFRTNCLDCLDRTNVIQSL 410
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072982768 478 YGLVaFGRQLHALGLTEsatvDLDNPLAEDLMGIYETMGDTLALQYGGSAAHNKIFCeRRGQWKAATQSQELFRTLQRYY 557
Cdd:COG5329   411 ISRV-LLEQFRSEGVIS----DGYSPFLQIHRELWADNGDAISRLYTGTGALKSSFT-RRGRRSFAGALNDFIKSFSRYY 484
                         490       500
                  ....*....|....*....|...
gi 1072982768 558 SNAYMDAEKQDAINLFLGYFQPQ 580
Cdd:COG5329   485 INNFTDGQRQDAIDLLLGKFRPQ 507
 
Name Accession Description Interval E-value
Syja_N pfam02383
SacI homology domain; This Pfam family represents a protein domain which shows homology to the ...
95-393 1.41e-121

SacI homology domain; This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.


Pssm-ID: 460545  Cd Length: 295  Bit Score: 366.90  E-value: 1.41e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072982768  95 YGIIGFIRFLGPYYMLIITKRRKLGEVCGHTVYGVAKSRIVTIPHAS--VLSNVAYSKDEKRYKRLLCSVDLTKDFFFSY 172
Cdd:pfam02383   1 YGILGLIRLLSGYYLIVITKREQVGQIGGHPIYKITDVEFIPLNSSLsdTQLAKKEHPDEERLLKLLKLFLSSGSFYFSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072982768 173 SYHIMHSLQRNLTNNAEGHIYYESM-FVWNEYLTRRIRNSTKD-CMWTVALVYGFFKQVKLSVSEKNFRLTLIARRSRHY 250
Cdd:pfam02383  81 DYDLTNSLQRNLTRSRSPSFDSLDDrFFWNRHLLKPLIDFQLDlDRWILPLIQGFVEQGKLSVFGRSVTLTLISRRSRKR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072982768 251 AGTRYLKRGVNEKGRVANDVETEQIVYEDAQDGHPvRISSVVQNRGSIPLFWSQDTSrLNIKPDIILSGKDPNFEATRLH 330
Cdd:pfam02383 161 AGTRYLRRGIDDDGNVANFVETEQIVSLNTSNSEG-KIFSFVQIRGSIPLFWSQDPN-LKYKPKIQITRPEATQPAFKKH 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1072982768 331 FENLARRYGnPIIVLNLIktrEKRPRETILRVEFANAIKFINKGLSKeeRLRPLHWDLHKHSR 393
Cdd:pfam02383 239 FDDLIERYG-PVHIVNLV---EKKGRESKLSEAYEEAVKYLNQFLPD--KLRYTAFDFHHECK 295
COG5329 COG5329
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
95-580 1.28e-84

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 279.66  E-value: 1.28e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072982768  95 YGIIGFIRFLGPYYMLIITKRRKLGEVCGHTVYGVAKSRIVTIphasvlsNVAYSKDEK-----RYKRLLCSVDLTKD-- 167
Cdd:COG5329    61 YGVIGLIKLKGDIYLIVITGASLVGVIPGHSIYKILDVDFISL-------NNNKWDDELeedeaNYDKLSELKKLLSNgt 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072982768 168 FFFSYSYHIMHSLQRNL-TNNAEGHIYYESMFVWNEYLTRRIRN--------STKDCMWTVALVYGFFKQVKLSVSEKNF 238
Cdd:COG5329   134 FYFSYDFDITNSLQKNLsEGLEASVDRADLIFMWNSFLLEEFINhrsklsslEKQFDNFLTTVIRGFAETVDIKVGGNTI 213
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072982768 239 RLTLIARRSRHYAGTRYLKRGVNEKGRVANDVETEQIVYeDAQdghpvRISSVVQNRGSIPLFWSQDTSRlnIKPDIILS 318
Cdd:COG5329   214 SLTLISRRSSERAGTRYLSRGIDDDGNVSNFVETEQIVT-DSQ-----YIFSFTQVRGSIPLFWEQSNLL--YGPKIKVT 285
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072982768 319 GKDPNFE-ATRLHFENLARRYGnPIIVLNLIKTREkrpRETILRVEFANAIKfinkgLSKEERLRPLHWDLHKHSRKKGt 397
Cdd:COG5329   286 RSSEAAQsAFDKHFDKLREKYG-DVYVVNLLKTKG---YEAPLLELYEKHLD-----LSKKPKIHYTEFDFHKETSQDG- 355
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072982768 398 nvLAILGRLATYALNLtgvfycqLTPDGFQNNAGecsttdeiasdslvekNGNDTTVLQKGVLRTNCIDCLDRTNVAQYA 477
Cdd:COG5329   356 --FDDVKKLLYLIEQD-------LLEFGYFAYDI----------------NEGKSISEQDGVFRTNCLDCLDRTNVIQSL 410
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072982768 478 YGLVaFGRQLHALGLTEsatvDLDNPLAEDLMGIYETMGDTLALQYGGSAAHNKIFCeRRGQWKAATQSQELFRTLQRYY 557
Cdd:COG5329   411 ISRV-LLEQFRSEGVIS----DGYSPFLQIHRELWADNGDAISRLYTGTGALKSSFT-RRGRRSFAGALNDFIKSFSRYY 484
                         490       500
                  ....*....|....*....|...
gi 1072982768 558 SNAYMDAEKQDAINLFLGYFQPQ 580
Cdd:COG5329   485 INNFTDGQRQDAIDLLLGKFRPQ 507
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH