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Conserved domains on  [gi|1072747004|gb|AOT25502|]
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HNH endonuclease [Mycobacterium phage BabyRay]

Protein Classification

HNH endonuclease( domain architecture ID 10003646)

HNH endonuclease contains an HNH endonuclease signature motif and may catalyze the hydrolysis of DNA

Gene Ontology:  GO:0004519|GO:0003676|GO:0008270
PubMed:  28211904

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
21-71 1.44e-07

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


:

Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 44.20  E-value: 1.44e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 1072747004 21 RQPVLRAAGYRCQIqlpgCLRK----ATDVDHI---RRGDDHRLSNLQAACSRCHGKK 71
Cdd:COG1403   11 RRAVLKRDNGRCQY----CGRPfsgdALEVDHIiprSRGGTDTWENLVLLCRRCNRRK 64
 
Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
21-71 1.44e-07

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 44.20  E-value: 1.44e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 1072747004 21 RQPVLRAAGYRCQIqlpgCLRK----ATDVDHI---RRGDDHRLSNLQAACSRCHGKK 71
Cdd:COG1403   11 RRAVLKRDNGRCQY----CGRPfsgdALEVDHIiprSRGGTDTWENLVLLCRRCNRRK 64
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 24-72 3.26e-06

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 40.92  E-value: 3.26e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 1072747004 24 VLRAAGYRCQIQLPGCLRKATDVDHI---RRGDDHRLSNLQAACSRCHGKKS 72
Cdd:cd00085    6 VLLARDGLCPYCGKPGGTEGLEVDHIiplSDGGNNDLDNLVLLCRKCHRKKH 57
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 37-73 4.93e-04

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 35.02  E-value: 4.93e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 1072747004 37 PGCLRKATDVDHI---RRGDDHRLSNLQAACSRCHGKKSS 73
Cdd:pfam01844  7 PFHISDALTVDHIiplSDGGADDIENLILLCPSCHNKKHN 46
HNHc smart00507
HNH nucleases;
24-68 3.47e-03

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 32.81  E-value: 3.47e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1072747004  24 VLRAAGYRCQIqlpgCLRKA---TDVDHI---RRGDDHRLSNLQAACSRCH 68
Cdd:smart00507  5 LLLHRDGVCAY----CGKPAsegLEVDHIiplSDGGNDDLDNLVLLCPKCH 51
 
Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
21-71 1.44e-07

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 44.20  E-value: 1.44e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 1072747004 21 RQPVLRAAGYRCQIqlpgCLRK----ATDVDHI---RRGDDHRLSNLQAACSRCHGKK 71
Cdd:COG1403   11 RRAVLKRDNGRCQY----CGRPfsgdALEVDHIiprSRGGTDTWENLVLLCRRCNRRK 64
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 24-72 3.26e-06

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 40.92  E-value: 3.26e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 1072747004 24 VLRAAGYRCQIQLPGCLRKATDVDHI---RRGDDHRLSNLQAACSRCHGKKS 72
Cdd:cd00085    6 VLLARDGLCPYCGKPGGTEGLEVDHIiplSDGGNNDLDNLVLLCRKCHRKKH 57
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 37-73 4.93e-04

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 35.02  E-value: 4.93e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 1072747004 37 PGCLRKATDVDHI---RRGDDHRLSNLQAACSRCHGKKSS 73
Cdd:pfam01844  7 PFHISDALTVDHIiplSDGGADDIENLILLCPSCHNKKHN 46
HNHc smart00507
HNH nucleases;
24-68 3.47e-03

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 32.81  E-value: 3.47e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1072747004  24 VLRAAGYRCQIqlpgCLRKA---TDVDHI---RRGDDHRLSNLQAACSRCH 68
Cdd:smart00507  5 LLLHRDGVCAY----CGKPAsegLEVDHIiplSDGGNDDLDNLVLLCPKCH 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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