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Conserved domains on  [gi|1072314160|ref|NP_001333154|]
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WD repeat-containing protein 48 isoform 4 [Homo sapiens]

Protein Classification

WD repeat WDR48 family protein( domain architecture ID 10078073)

WD repeat WDR48 family protein similar to WD repeat-containing protein 48, a regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3337 pfam11816
Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. ...
 547-711 1.74e-59

Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. This family is only found in eukaryotes. This presumed domain is typically between 285 to 342 amino acids in length.


:

Pssm-ID: 463358  Cd Length: 171  Bit Score: 197.90  E-value: 1.74e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 547 VPPHTPVIFGE-----AGGRTLFRLLCRDSGGETEsmLLNETVPQWVIDITVDKNMP--KFNKIPFYLQPHASSGAKTL- 618
Cdd:pfam11816   1 LPPDTTIIISEespdsGGGRDLYRGTVGDIGEDVD--LLEEVAPMWLGDVLLYNKIPpkEPVKISFVLQPWPGSDLPPDk 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 619 ------KKDRLSASDMLQVRKVMEHVYEKIINLDNESQTTSSSNNEKPGEQEKeediavlAEEKIELLCQDQVLDPNMDL 692
Cdd:pfam11816  79 lpelpnKNSRLNANRMLRVRKILAYVAEKLESLTPEMKPPSPDEDENADKKLK-------PEEYLELLCNDQVLPPNMTL 151

                         170
                  ....*....|....*....
gi 1072314160 693 RTVKHFIWKSGGDLTLHYR 711
Cdd:pfam11816 152 ATVKTFIWKSGGDIVLHYR 170
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 30-324 2.29e-55

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 191.01  E-value: 2.29e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQhkqDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFC 109
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLET---GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 110 MSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvtslhresvsyfesastysvlapksmieqqr 189
Cdd:cd00200    86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT------------------------------------ 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 190 assslqsknasSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSD 269
Cdd:cd00200   130 -----------TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD 198

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1072314160 270 GTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDI 324
Cdd:cd00200   199 GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC 253
 
Name Accession Description Interval E-value
DUF3337 pfam11816
Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. ...
 547-711 1.74e-59

Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. This family is only found in eukaryotes. This presumed domain is typically between 285 to 342 amino acids in length.


Pssm-ID: 463358  Cd Length: 171  Bit Score: 197.90  E-value: 1.74e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 547 VPPHTPVIFGE-----AGGRTLFRLLCRDSGGETEsmLLNETVPQWVIDITVDKNMP--KFNKIPFYLQPHASSGAKTL- 618
Cdd:pfam11816   1 LPPDTTIIISEespdsGGGRDLYRGTVGDIGEDVD--LLEEVAPMWLGDVLLYNKIPpkEPVKISFVLQPWPGSDLPPDk 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 619 ------KKDRLSASDMLQVRKVMEHVYEKIINLDNESQTTSSSNNEKPGEQEKeediavlAEEKIELLCQDQVLDPNMDL 692
Cdd:pfam11816  79 lpelpnKNSRLNANRMLRVRKILAYVAEKLESLTPEMKPPSPDEDENADKKLK-------PEEYLELLCNDQVLPPNMTL 151

                         170
                  ....*....|....*....
gi 1072314160 693 RTVKHFIWKSGGDLTLHYR 711
Cdd:pfam11816 152 ATVKTFIWKSGGDIVLHYR 170
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 30-324 2.29e-55

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 191.01  E-value: 2.29e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQhkqDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFC 109
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLET---GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 110 MSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvtslhresvsyfesastysvlapksmieqqr 189
Cdd:cd00200    86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT------------------------------------ 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 190 assslqsknasSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSD 269
Cdd:cd00200   130 -----------TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD 198

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1072314160 270 GTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDI 324
Cdd:cd00200   199 GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
30-314 4.41e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 188.58  E-value: 4.41e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFC 109
Cdd:COG2319   120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL---LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 110 MSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT---LTALTASNNTVTSLhresvsyfesastysVLAPKSmie 186
Cdd:COG2319   197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATgklLRTLTGHSGSVRSV---------------AFSPDG--- 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 187 QQRASSS---------LQS-KNASSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLL 256
Cdd:COG2319   259 RLLASGSadgtvrlwdLATgELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 338

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1072314160 257 NRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALqvndAFT----HVYSGGRDRKI 314
Cdd:COG2319   339 SPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV----AFSpdgrTLASGSADGTV 396
Ubl_WDR48 cd17041
Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar ...
 599-711 4.50e-48

Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar proteins; WDR48, also termed USP1-associated factor 1 (UAF1), or WD repeat endosomal protein, or p80, is required for the histone deubiquitination activity. It stimulates activity of ubiquitin-specific proteases USP1, USP12, and USP46.As potential tumor suppressor, WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). WDR48 also functions as a novel interaction partner of E1 helicase from anogenital human papillomavirus (HPV) types, and plays an essential role in anogenital HPV DNA replication. WDR48 contains a WD40 domain and a ubiquitin-like domain that shows high sequence and structural similarity with RING finger- and WD40-associated ubiquitin-like (RAWUL) domain.


Pssm-ID: 340561  Cd Length: 97  Bit Score: 164.38  E-value: 4.50e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 599 KFNKIPFYLQPHASSGA--KTLKKDRLSASDMLQVRKVMEHVYEKIINLDNESQTtsssnnekpgeqekeediAVLAEEK 676
Cdd:cd17041     1 EFPKISFFLQPHPSSGLppKTLKNDKLSASRMLRVRKVMEYVAEKLLGQEPESQD------------------ASNPEEK 62

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1072314160 677 IELLCQDQVLDPNMDLRTVKHFIWKSGGDLTLHYR 711
Cdd:cd17041    63 LELLCNDQVLDPNMTLATVKHFIWKSGGDLVLHYR 97
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 113-324 2.60e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 60.49  E-value: 2.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 113 LRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTaltasnNTVTSLHRESVSyFESASTYSVLAPKSMIEQQRASS 192
Cdd:PLN00181  479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESII------KDGRDIHYPVVE-LASRSKLSGICWNSYIKSQVASS 551

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 193 SLqsknasslsgnkdsiyslamnqlgtiivsgstEKVLRVWDPRTCAKLMKLKGHTDNVKAL-LLNRDGTQCLSGSSDGT 271
Cdd:PLN00181  552 NF--------------------------------EGVVQVWDVARSQLVTEMKEHEKRVWSIdYSSADPTLLASGSDDGS 599

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1072314160 272 IRLWSLGQQRCIATYRVhDEGVWALQV-NDAFTHVYSGGRDRKIYCTDLRNPDI 324
Cdd:PLN00181  600 VKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAFGSADHKVYYYDLRNPKL 652
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 237-276 5.25e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 5.25e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1072314160  237 TCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWS 276
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
241-276 1.61e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.61e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1072314160 241 LMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWS 276
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
DUF3337 pfam11816
Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. ...
 547-711 1.74e-59

Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. This family is only found in eukaryotes. This presumed domain is typically between 285 to 342 amino acids in length.


Pssm-ID: 463358  Cd Length: 171  Bit Score: 197.90  E-value: 1.74e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 547 VPPHTPVIFGE-----AGGRTLFRLLCRDSGGETEsmLLNETVPQWVIDITVDKNMP--KFNKIPFYLQPHASSGAKTL- 618
Cdd:pfam11816   1 LPPDTTIIISEespdsGGGRDLYRGTVGDIGEDVD--LLEEVAPMWLGDVLLYNKIPpkEPVKISFVLQPWPGSDLPPDk 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 619 ------KKDRLSASDMLQVRKVMEHVYEKIINLDNESQTTSSSNNEKPGEQEKeediavlAEEKIELLCQDQVLDPNMDL 692
Cdd:pfam11816  79 lpelpnKNSRLNANRMLRVRKILAYVAEKLESLTPEMKPPSPDEDENADKKLK-------PEEYLELLCNDQVLPPNMTL 151

                         170
                  ....*....|....*....
gi 1072314160 693 RTVKHFIWKSGGDLTLHYR 711
Cdd:pfam11816 152 ATVKTFIWKSGGDIVLHYR 170
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 30-324 2.29e-55

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 191.01  E-value: 2.29e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQhkqDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFC 109
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLET---GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 110 MSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvtslhresvsyfesastysvlapksmieqqr 189
Cdd:cd00200    86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT------------------------------------ 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 190 assslqsknasSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSD 269
Cdd:cd00200   130 -----------TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD 198

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1072314160 270 GTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDI 324
Cdd:cd00200   199 GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
30-314 4.41e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 188.58  E-value: 4.41e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFC 109
Cdd:COG2319   120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL---LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 110 MSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT---LTALTASNNTVTSLhresvsyfesastysVLAPKSmie 186
Cdd:COG2319   197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATgklLRTLTGHSGSVRSV---------------AFSPDG--- 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 187 QQRASSS---------LQS-KNASSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLL 256
Cdd:COG2319   259 RLLASGSadgtvrlwdLATgELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 338

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1072314160 257 NRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALqvndAFT----HVYSGGRDRKI 314
Cdd:COG2319   339 SPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV----AFSpdgrTLASGSADGTV 396
WD40 COG2319
WD40 repeat [General function prediction only];
30-321 2.22e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 181.26  E-value: 2.22e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFC 109
Cdd:COG2319    78 TAAVLSVAFSPDGRLLASASADGTVRLWDLATGLL---LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 110 MSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT---LTALTASNNTVTSLhresvsyfesastysVLAPKSmie 186
Cdd:COG2319   155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATgklLRTLTGHTGAVRSV---------------AFSPDG--- 216

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 187 QQRASSSL----------QSKNASSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLL 256
Cdd:COG2319   217 KLLASGSAdgtvrlwdlaTGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1072314160 257 NRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRN 321
Cdd:COG2319   297 SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361
Ubl_WDR48 cd17041
Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar ...
 599-711 4.50e-48

Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar proteins; WDR48, also termed USP1-associated factor 1 (UAF1), or WD repeat endosomal protein, or p80, is required for the histone deubiquitination activity. It stimulates activity of ubiquitin-specific proteases USP1, USP12, and USP46.As potential tumor suppressor, WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). WDR48 also functions as a novel interaction partner of E1 helicase from anogenital human papillomavirus (HPV) types, and plays an essential role in anogenital HPV DNA replication. WDR48 contains a WD40 domain and a ubiquitin-like domain that shows high sequence and structural similarity with RING finger- and WD40-associated ubiquitin-like (RAWUL) domain.


Pssm-ID: 340561  Cd Length: 97  Bit Score: 164.38  E-value: 4.50e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 599 KFNKIPFYLQPHASSGA--KTLKKDRLSASDMLQVRKVMEHVYEKIINLDNESQTtsssnnekpgeqekeediAVLAEEK 676
Cdd:cd17041     1 EFPKISFFLQPHPSSGLppKTLKNDKLSASRMLRVRKVMEYVAEKLLGQEPESQD------------------ASNPEEK 62

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1072314160 677 IELLCQDQVLDPNMDLRTVKHFIWKSGGDLTLHYR 711
Cdd:cd17041    63 LELLCNDQVLDPNMTLATVKHFIWKSGGDLVLHYR 97
WD40 COG2319
WD40 repeat [General function prediction only];
30-277 2.35e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.09  E-value: 2.35e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFC 109
Cdd:COG2319   162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL---LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 110 MSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT---LTALTASNNTVTSLhresvsyfesastysVLAPKSmie 186
Cdd:COG2319   239 LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATgelLRTLTGHSGGVNSV---------------AFSPDG--- 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 187 QQRASSSLQS----------KNASSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLL 256
Cdd:COG2319   301 KLLASGSDDGtvrlwdlatgKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380

                         250       260
                  ....*....|....*....|.
gi 1072314160 257 NRDGTQCLSGSSDGTIRLWSL 277
Cdd:COG2319   381 SPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
33-314 2.01e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 156.22  E-value: 2.01e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160  33 VNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMST 112
Cdd:COG2319    39 VASLAASPDGARLAAGAGDLTLLLLDAAAGAL---LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRT 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 113 LRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNT---LTALTASNNTVTSLhresvsyfesastysVLAPKSmieQQR 189
Cdd:COG2319   116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATgklLRTLTGHSGAVTSV---------------AFSPDG---KLL 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 190 ASSS----------LQSKNASSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRD 259
Cdd:COG2319   178 ASGSddgtvrlwdlATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD 257

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1072314160 260 GTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALqvndAFT----HVYSGGRDRKI 314
Cdd:COG2319   258 GRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV----AFSpdgkLLASGSDDGTV 312
WD40 COG2319
WD40 repeat [General function prediction only];
37-328 3.54e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 129.26  E-value: 3.54e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160  37 QLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTH 116
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGAL---LLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 117 KDYVKALAYAKDKELVASAGLDRQIFLWDVNT---LTALTASNNTVTSLhresvsyfesastysVLAPKSmieQQRASSS 193
Cdd:COG2319    78 TAAVLSVAFSPDGRLLASASADGTVRLWDLATgllLRTLTGHTGAVRSV---------------AFSPDG---KTLASGS 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 194 ---------LQS-KNASSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQC 263
Cdd:COG2319   140 adgtvrlwdLATgKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLL 219

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1072314160 264 LSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALqvndAF----THVYSGGRDRKIYCTDLRNPDIRVLI 328
Cdd:COG2319   220 ASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV----AFspdgRLLASGSADGTVRLWDLATGELLRTL 284
WD40 COG2319
WD40 repeat [General function prediction only];
31-237 6.19e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.85  E-value: 6.19e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160  31 NGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCM 110
Cdd:COG2319   247 GSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL---LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 111 STLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvtslhresvsyfesastysvlapksmieqqra 190
Cdd:COG2319   324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR------------------------------------- 366

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1072314160 191 ssslqsknasSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRT 237
Cdd:COG2319   367 ----------TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 202-314 3.95e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.02  E-value: 3.95e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 202 LSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQR 281
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1072314160 282 CIATYRVHDEGVWALQVNDAFTHVYSGGRDRKI 314
Cdd:cd00200    85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTI 117
WD40 COG2319
WD40 repeat [General function prediction only];
29-104 2.77e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.09  E-value: 2.77e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1072314160  29 NRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNA 104
Cdd:COG2319   329 HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL---LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 244-333 7.43e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.81  E-value: 7.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 244 LKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPD 323
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                          90
                  ....*....|.
gi 1072314160 324 -IRVLICEEKA 333
Cdd:cd00200    85 cVRTLTGHTSY 95
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 113-324 2.60e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 60.49  E-value: 2.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 113 LRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTaltasnNTVTSLHRESVSyFESASTYSVLAPKSMIEQQRASS 192
Cdd:PLN00181  479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESII------KDGRDIHYPVVE-LASRSKLSGICWNSYIKSQVASS 551

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 193 SLqsknasslsgnkdsiyslamnqlgtiivsgstEKVLRVWDPRTCAKLMKLKGHTDNVKAL-LLNRDGTQCLSGSSDGT 271
Cdd:PLN00181  552 NF--------------------------------EGVVQVWDVARSQLVTEMKEHEKRVWSIdYSSADPTLLASGSDDGS 599

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1072314160 272 IRLWSLGQQRCIATYRVhDEGVWALQV-NDAFTHVYSGGRDRKIYCTDLRNPDI 324
Cdd:PLN00181  600 VKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAFGSADHKVYYYDLRNPKL 652
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 237-276 5.25e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 5.25e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1072314160  237 TCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWS 276
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
Ubiquitin_like_fold cd00196
Beta-grasp ubiquitin-like fold; Ubiquitin is a protein modifier that is involved in various ...
 616-711 6.74e-07

Beta-grasp ubiquitin-like fold; Ubiquitin is a protein modifier that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair in eukaryotes. The ubiquitination process comprises a cascade of E1, E2 and E3 enzymes that results in a covalent bond between the C-terminus of ubiquitin and the epsilon-amino group of a substrate lysine. Ubiquitin-like proteins have similar ubiquitin beta-grasp fold and attach to other proteins in a ubiquitin-like manner but with biochemically distinct roles. Ubiquitin and ubiquitin-like proteins conjugate and deconjugate via ligases and peptidases to covalently modify target polypeptides. Some other ubiquitin-like domains have adaptor roles in ubiquitin-signaling by mediating protein-protein interaction. In addition to Ubiquitin-like (Ubl) domain, Ras-associating (RA) domain, F0/F1 sub-domain of FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, TGS (ThrRS, GTPase and SpoT) domain, Ras-binding domain (RBD), Ubiquitin regulatory domain X (UBX), Dublecortin-like domain, and RING finger- and WD40-associated ubiquitin-like (RAWUL) domain have beta-grasp ubiquitin-like folds, and are included in this superfamily.


Pssm-ID: 340450  Cd Length: 68  Bit Score: 46.93  E-value: 6.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 616 KTLKKDRLSASDMLQVRKVMEHVYEKIInldnesqttsssnnekpgeqekeediavLAEEKIELLCQDQVLDPNMDLRTv 695
Cdd:cd00196     6 PSLKKIVVAVPPSTTLRQVLEKVAKRIG----------------------------LPPDVIRLLFNGQVLDDLMTAKQ- 56

                          90
                  ....*....|....*.
gi 1072314160 696 khfiWKSGGDLTLHYR 711
Cdd:cd00196    57 ----VGLEPGEELHFV 68
WD40 pfam00400
WD domain, G-beta repeat;
241-276 1.61e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.61e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1072314160 241 LMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWS 276
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 68-103 2.22e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 2.22e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1072314160   68 IASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWN 103
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
68-103 7.31e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 7.31e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1072314160  68 IASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWN 103
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 106-145 1.63e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.63e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1072314160  106 KGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 145
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
107-145 4.77e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 4.77e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1072314160 107 GFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 145
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 41-151 1.16e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.27  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160  41 ALNRLFTAGRDSIIRIWSVNQHKQDPYIASmehHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKD-Y 119
Cdd:PTZ00421  137 AMNVLASAGADMVVNVWDVERGKAVEVIKC---HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASaK 213

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1072314160 120 VKALAYAKDKELVASAGLD----RQIFLWDVNTLTA 151
Cdd:PTZ00421  214 SQRCLWAKRKDLIITLGCSksqqRQIMLWDTRKMAS 249
PTZ00421 PTZ00421
coronin; Provisional
 44-145 3.30e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 43.73  E-value: 3.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160  44 RLFTAGRDSIIRIWSV-----NQHKQDPyIASMEHHTDWVNDIVLCCNGK-TLISASSDTTVKVWNAHKGFCMSTLRTHK 117
Cdd:PTZ00421   90 KLFTASEDGTIMGWGIpeeglTQNISDP-IVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHS 168

                          90       100
                  ....*....|....*....|....*...
gi 1072314160 118 DYVKALAYAKDKELVASAGLDRQIFLWD 145
Cdd:PTZ00421  169 DQITSLEWNLDGSLLCTTSKDKKLNIID 196
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 200-234 6.82e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 6.82e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1072314160  200 SSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWD 234
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
201-234 1.69e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.69e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1072314160 201 SLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWD 234
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
RAWUL pfam16207
RAWUL domain RING finger- and WD40-associated ubiquitin-like; The RAWUL domain is found at the ...
 676-711 6.70e-03

RAWUL domain RING finger- and WD40-associated ubiquitin-like; The RAWUL domain is found at the C-terminus of poly-comb group RING finger proteins. It is a ubiquitin-like domain. RAWUL binds directly to PUFD, a domain on BCOR proteins (BCL6 corepressor). BCOR has emerged as an important player in development and health.


Pssm-ID: 465067  Cd Length: 66  Bit Score: 35.61  E-value: 6.70e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1072314160 676 KIELLCQDQVLDPNMDLRTVKHFIWKSGGDLTLHYR 711
Cdd:pfam16207  31 IVEILYNGEPLPDSYTLDVAYIKYWKRNAPLELYYR 66
PTZ00421 PTZ00421
coronin; Provisional
 86-240 7.81e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.49  E-value: 7.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160  86 NGKTLISASSDTTVKVWN-AHKGFCMST------LRTHKDYVKALAY-AKDKELVASAGLDRQIFLWDVNTLTALtasnn 157
Cdd:PTZ00421   87 DPQKLFTASEDGTIMGWGiPEEGLTQNIsdpivhLQGHTKKVGIVSFhPSAMNVLASAGADMVVNVWDVERGKAV----- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314160 158 TVTSLHRESVSYFESASTYSVLAPKSM-----IEQQRASSSLQSKNASSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRV 232
Cdd:PTZ00421  162 EVIKCHSDQITSLEWNLDGSLLCTTSKdkklnIIDPRDGTIVSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQQRQIML 241


                  ....*...
gi 1072314160 233 WDPRTCAK 240
Cdd:PTZ00421  242 WDTRKMAS 249
RAWUL_PCGF_like cd16102
RRING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in PCGF1-6, RING1 and -2, ...
 673-711 8.80e-03

RRING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in PCGF1-6, RING1 and -2, DRIP and similar proteins; structurally similar to a beta-grasp ubiquitin-like fold; The family includes six Polycomb Group (PcG) RING finger homologs (PCGF1/NSPc1, PCGF2/Mel-18, PCGF3, PCGF4/BMI1, PCGF5, and PCGF6/MBLR) that use epigenetic mechanisms to maintain or repress expression of their target genes. They were first discovered in fruit flies that can remodel chromatin such that epigenetic silencing of genes takes place, and are well known for silencing Hox genes through modulation of chromatin structure during embryonic development in fruit flies. PCGF homologs play important roles in cell proliferation, differentiation, and tumorigenesis. They all have been found to associate with ring finger protein 2 (RNF2). The RNF2-PCGF heterodimer is catalytically competent as an E3 ubiquitin transferase and is the scaffold for the assembly of additional components. Moreover, PCGF homologs are critical components in the assembly of distinct Polycomb Repression Complex 1 (PRC1) related complexes which are involved in the maintenance of gene repression and target different genes through distinct mechanisms. The Drosophila PRC1 core complex is formed by the Polycomb (Pc), Polyhomeotic (Ph), Posterior sex combs (Psc), and Sex combs extra (Sce, also known as Ring) subunits. In mammals, the composition of PRC1 is much more diverse and varies depending on the cellular context. All PRC1 complexes contain homologs of the Drosophila Ring protein. Ring1A/RNF1 and Ring1B/RNF2 are E3 ubiquitin ligases that mark lysine 119 of histone H2A with a single ubiquitin group (H2AK119ub). Mammalian homologs of the Drosophila Psc protein, such as PCGF2/Mel-18 or PCGF4/BMI1, regulate PRC1 enzymatic activity. PRC1 complexes can be divided into at least two classes according to the presence or absence of CBX proteins, which are homologs of Drosophila Pc. Canonical PRC1 complexes contain CBX proteins that recognize and bind H3K27me3, the mark deposited by PRC2. Therefore, canonical PRC1 complexes and PRC2 can act together to repress gene transcription and maintain this repression through cell division. Non-canonical PRC1 complexes, containing RYBP (together with additional proteins, such as L3mbtl2 or Kdm2b) rather than the CBX proteins, have recently been described in mammals. PCGF homologs contain a C3HC4-type RING-HC finger, and a RAWUL domain that might be responsible for interaction with Cbx members of the Polycomb repression complexes.


Pssm-ID: 340519  Cd Length: 87  Bit Score: 36.10  E-value: 8.80e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1072314160 673 AEEKIELLCQDQVLDPNMDLRTVKHFIW-KSGGDLTLHYR 711
Cdd:cd16102    48 SEQDLDILCRGELLGKEHTLKFIWRTRWrKQDGPLVLQYR 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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