|
Name |
Accession |
Description |
Interval |
E-value |
| LamNT |
smart00136 |
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ... |
16-268 |
5.93e-91 |
|
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.
:
Pssm-ID: 214532 Cd Length: 238 Bit Score: 295.81 E-value: 5.93e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 16 QCQLRGLFPAILNLASKADISTNATCGEMGPEMFCKLVEHVpgriDRNPQCRICDQNsvNAKERHPITNAIDGTND---- 91
Cdd:smart00136 1 AGRPRSCYPPFVNLAFGREVTATSTCGEPGPERYCKLVGHT----EQGKKCDYCDAR--NPRRSHPAENLTDGNNPnnpt 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 92 WWQSPSIQNGRlyHWITLTLDLKQVFQVAYVIIKAAnSPRPGNWILEHSFDGVEFMPWQYYAisdTECLTRYNITPRLGP 171
Cdd:smart00136 75 WWQSEPLSNGP--QNVNLTLDLGKEFHVTYVILKFC-SPRPSLWILERSDFGKTWQPWQYFS---SDCRRTFGRPPRGPI 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 172 PTYKrDDEVICTSYYSRLVPLEHGEIHTSLINGRPSADDP--SPTLLDFTSARYIRLRLQRIRTLNADLMTLShndlrnv 249
Cdd:smart00136 149 TKGN-EDEVICTSEYSDIVPLEGGEIAFSLLEGRPSATDFdnSPVLQEWVTATNIRVRLTRLRTLGDELMDDR------- 220
|
250
....*....|....*....
gi 1072240033 250 dPIVTRRYYYSIKDISVGG 268
Cdd:smart00136 221 -PEVTRRYYYAISDIAVGG 238
|
|
| Laminin_B |
pfam00052 |
Laminin B (Domain IV); |
1216-1358 |
3.59e-43 |
|
Laminin B (Domain IV);
:
Pssm-ID: 459652 Cd Length: 136 Bit Score: 154.74 E-value: 3.59e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1216 YWKLPSQFLGEKTLAYGGMLKYVVTYYGLGESGPSDFEPHIIMKGGHLRKQVLYMAKPNPVNGVRTETQISFKEEDWKYH 1295
Cdd:pfam00052 1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGGSLNSEPDVILEGNGLRLSYSSPDQPPPDPGQEQTYSVRLHEENWRDS 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1072240033 1296 NSVsdeSVTRMDFMSVLSKLDYILIKASYGYGLQQSRISNISMDIAVEAAemhSGrEAANLIE 1358
Cdd:pfam00052 81 DGA---PVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSAVPGG---SG-PPASWVE 136
|
|
| Laminin_B |
pfam00052 |
Laminin B (Domain IV); |
566-705 |
1.42e-42 |
|
Laminin B (Domain IV);
:
Pssm-ID: 459652 Cd Length: 136 Bit Score: 153.19 E-value: 1.42e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 566 YWEAPSSYLGNKLTSYGGVLRYTVSYDIPVESldREPVSNVDLVMQGSGITIVTRTEGLL-LQPYEEHTAEIKLLPENFL 644
Cdd:pfam00052 1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGG--GSLNSEPDVILEGNGLRLSYSSPDQPpPDPGQEQTYSVRLHEENWR 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1072240033 645 DfYTNRPLDRDRLMTVLANINRLWIRATYNNDKNAVtRLSSVTLDTATPNVIDlLPAVQVE 705
Cdd:pfam00052 79 D-SDGAPVSREDFMMVLANLTAILIRATYSTGSGQV-SLSNVSLDSAVPGGSG-PPASWVE 136
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
2309-2465 |
1.03e-41 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
:
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 151.42 E-value: 1.03e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2309 SFYFDGSGY-SIVEKTMRSTTTQIVIHFRTFSPNGLLLYLASNGTRDFLSLEIVDGKLRLSVELGSGPLTLTTDGRYNDG 2387
Cdd:cd00110 1 GVSFSGSSYvRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDG 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1072240033 2388 NWYKVAFQRNKKQGILAVmDSYNSsqrenkqGEAPGTASDLNRSDKDPIYIGGLPRSRVVRRQLVSRSYVGCIRNLEI 2465
Cdd:cd00110 81 QWHSVSVERNGRSVTLSV-DGERV-------VESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
|
|
| Laminin_II super family |
cl05515 |
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 ... |
2013-2147 |
3.50e-40 |
|
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.
The actual alignment was detected with superfamily member pfam06009:
Pssm-ID: 368703 [Multi-domain] Cd Length: 138 Bit Score: 146.48 E-value: 3.50e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2013 AKDLALSANTTAAGTLGHIMNFSQKLSNATSTLSRVNDTLQRTNVLLVDSSKAAVSAESRIKEVETQANILLDRLKPMKL 2092
Cdd:pfam06009 1 SKELAREANETAKEVLEQLAPLSQNLENTSEKLSGINRSLEETNELVNDANKALDDAGRSVKKLEELAPDLLDKLKPLKQ 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1072240033 2093 LEEN---LSRNLSEIKELINQARKQAASIKVAVSADRDCVRSYHPEIRSTNFNTLILN 2147
Cdd:pfam06009 81 LEVNsssLSDNISRIKELIAQARKAANSIKVSVSFDGDSIVELRPPISVTDLAAYTSL 138
|
|
| Laminin_G_1 |
pfam00054 |
Laminin G domain; |
2763-2891 |
1.44e-38 |
|
Laminin G domain;
:
Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 141.30 E-value: 1.44e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2763 RAYATSGLIYYMAHQNQMDYAALQLHDGKLHFLFDMGKGKTETIHPVLINDGKWHTISTEYIKRKSTITVDGQEATSTST 2842
Cdd:pfam00054 2 RTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGES 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2843 P-GESNSLDVEGKLYLGGLAPSYTAKNIGNVTHSIPACISNVSVNGKRLN 2891
Cdd:pfam00054 82 PlGATTDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
2911-3064 |
2.35e-36 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
:
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 136.01 E-value: 2.35e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2911 GTYFDGTGFAALVKEGYKvRFDLNISLEFRTTARNAVLLGISSA-KVDAIGLEIVNGRVLFHVNNGAGRITAIYKPeqan 2989
Cdd:cd00110 1 GVSFSGSSYVRLPTLPAP-RTRLSISFSFRTTSPNGLLLYAGSQnGGDFLALELEDGRLVLRYDLGSGSLVLSSKT---- 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1072240033 2990 SLCDGEWHQVNANKIKHKIVLKVDGNTILTDSPHVQSTSADTSNPVYVGGYPAGVKQNCLTSQTSFRGCIRNLKL 3064
Cdd:cd00110 76 PLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
|
|
| LamG |
smart00282 |
Laminin G domain; |
2143-2282 |
3.05e-30 |
|
Laminin G domain;
:
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 117.83 E-value: 3.05e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2143 TLILNVKTSEPDNLLFYMGSNSKADFMAVEMRQGKVSLLWDLGTGATRLEDPGMQINNNKWHKIHATRFGRSGTLaveEV 2222
Cdd:smart00282 1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTL---SV 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2223 NTSQKTSTkpsSSPGTSSILHVDnsTLMFIGGIGGGLQRSPALQTTDFRGCMGEAFLNGK 2282
Cdd:smart00282 78 DGGNRVSG---ESPGGLTILNLD--GPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
|
|
| Laminin_I super family |
cl26988 |
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ... |
1575-1821 |
3.91e-30 |
|
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.
The actual alignment was detected with superfamily member pfam06008:
Pssm-ID: 310534 [Multi-domain] Cd Length: 258 Bit Score: 121.75 E-value: 3.91e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1575 SINF-TGIVTVPHGFMTHLENMTMHVKDSVFTNSNKTQNLDQTVKQLNAVSADTVLLHNRLAQVKKHGFSVHNSTINTLN 1653
Cdd:pfam06008 3 SLNSlTGALPAPYKINYNLENLTKQLQEYLSPENAHKIQIEILEKELSSLAQETEELQKKATQTLAKAQQVNAESERTLG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1654 KSQELMGFIDKMQTTIKVLIEVAESLNEtlgSDALLPV----NYQEGVLSKLGELSTRSFSDHNQNAVENVKALDVLLSR 1729
Cdd:pfam06008 83 HAKELAEAIKNLIDNIKEINEKVATLGE---NDFALPSsdlsRMLAEAQRMLGEIRSRDFGTQLQNAEAELKAAQDLLSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1730 VQKEFGKPHDDLAKVKKSLENSLDQHTSKLLAAEDFIYESASNLNTTNNLLVVIQNNLEDFSVKKLNFQENKNRSVMLIE 1809
Cdd:pfam06008 160 IQTWFQSPQEENKALANALRDSLAEYEAKLSDLRELLREAAAKTRDANRLNLANQANLREFQRKKEEVSEQKNQLEETLK 239
|
250
....*....|..
gi 1072240033 1810 EGLGLVDEAVLL 1821
Cdd:pfam06008 240 TARDSLDAANLL 251
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
2490-2655 |
7.09e-26 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
:
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 105.96 E-value: 7.09e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2490 SITVLNDGYVEM-QPVSLSPESELMVSFSTLNDTGIILagfgkaaekRSRRQAQLPFFALMLINGHIELHINplDGASTr 2568
Cdd:cd00110 1 GVSFSGSSYVRLpTLPAPRTRLSISFSFRTTSPNGLLL---------YAGSQNGGDFLALELEDGRLVLRYD--LGSGS- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2569 kTVIRSPTgTYSDGQEHSIILLRNKRFVSVQVDEGKPAEVKLNGPSVDLVAINafRFFIGGVPGKMGATMLRTSQSFYGC 2648
Cdd:cd00110 69 -LVLSSKT-PLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDG--PLYLGGLPEDLKSPGLPVSPGFVGC 144
|
....*..
gi 1072240033 2649 IQNLILN 2655
Cdd:cd00110 145 IRDLKVN 151
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
900-946 |
3.05e-13 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
:
Pssm-ID: 395007 Cd Length: 49 Bit Score: 66.22 E-value: 3.05e-13
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1072240033 900 CECHPDSSISSMCHHDTGLCDCKPHVIGKKCDQCEPGFYGL--TSGLGC 946
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLpsDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
739-787 |
3.57e-11 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
:
Pssm-ID: 238012 Cd Length: 50 Bit Score: 60.45 E-value: 3.57e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1072240033 739 PCDCNGHAT---DCD-IHGACYgCQHNTTGPHCDQCIPGFYGYPTAgtPQDCQ 787
Cdd:cd00055 1 PCDCNGHGSlsgQCDpGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQ--GGGCQ 50
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
397-454 |
1.84e-10 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
:
Pssm-ID: 395007 Cd Length: 49 Bit Score: 58.52 E-value: 1.84e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1072240033 397 CECDPFGSVSPVCVVDDnhstqgalpGQCPCKEGYTGTKCNQCAFGYKGYPHCVRCNC 454
Cdd:pfam00053 1 CDCNPHGSLSDTCDPET---------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
949-993 |
2.13e-10 |
|
Laminin-type epidermal growth factor-like domai;
:
Pssm-ID: 214543 Cd Length: 46 Bit Score: 58.09 E-value: 2.13e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1072240033 949 CNCSLSGSNSGVCD-DAGQCPCVSGVAGVKCDVCAQGFYGYEDGGC 993
Cdd:smart00180 1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
452-498 |
2.41e-10 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
:
Pssm-ID: 395007 Cd Length: 49 Bit Score: 58.13 E-value: 2.41e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1072240033 452 CNCSLIGSLND--DPCADQCICKEHVEGENCDRCKSGFYNLQEKNPEGC 498
Cdd:pfam00053 1 CDCNPHGSLSDtcDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1507-1541 |
3.24e-10 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
:
Pssm-ID: 395007 Cd Length: 49 Bit Score: 57.75 E-value: 3.24e-10
10 20 30
....*....|....*....|....*....|....*
gi 1072240033 1507 CDCNPSGSLHNHCDRITGQCVCKVGVTGRLCDTCE 1541
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCK 35
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
846-898 |
3.66e-10 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
:
Pssm-ID: 238012 Cd Length: 50 Bit Score: 57.36 E-value: 3.66e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1072240033 846 PCDCNGNIDpfEDGHCDSVTGECLkCIGNTAGRYCERCADGFHGDAIFVKNCT 898
Cdd:cd00055 1 PCDCNGHGS--LSGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1042-1090 |
8.69e-10 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
:
Pssm-ID: 395007 Cd Length: 49 Bit Score: 56.59 E-value: 8.69e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1072240033 1042 CNCSTDGSSSLQCDLTTGQCLCRKEFAGQTCNTCLFGYRKYPSCISCDC 1090
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1401-1447 |
6.71e-08 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
:
Pssm-ID: 395007 Cd Length: 49 Bit Score: 51.20 E-value: 6.71e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1401 CQCSNH---SEICDPDTGECLgCTDNTAGHHCHVCASGYYGKVAGSITDC 1447
Cdd:pfam00053 1 CDCNPHgslSDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
996-1039 |
1.07e-07 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
:
Pssm-ID: 395007 Cd Length: 49 Bit Score: 50.43 E-value: 1.07e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1072240033 996 CDCEH---TQNNCNPQTGECICPPHTHGSKCEFCKANYWG--HDPELGC 1039
Cdd:pfam00053 1 CDCNPhgsLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGlpSDPPQGC 49
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1088-1145 |
3.28e-07 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
:
Pssm-ID: 395007 Cd Length: 49 Bit Score: 49.27 E-value: 3.28e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1072240033 1088 CDCDVKGTQSAWCDdeqkmcscgEETGNCACKDNVIGSYCNECKGGTFALHGENPLGC 1145
Cdd:pfam00053 1 CDCNPHGSLSDTCD---------PETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
789-844 |
4.72e-07 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
:
Pssm-ID: 395007 Cd Length: 49 Bit Score: 48.89 E-value: 4.72e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1072240033 789 CACPLNAPSnnfSPTCYLSGeedVICdQCAPGYTGPRCEKCANGYYGNPSVLGGSC 844
Cdd:pfam00053 1 CDCNPHGSL---SDTCDPET---GQC-LCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1450-1504 |
1.40e-06 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
:
Pssm-ID: 395007 Cd Length: 49 Bit Score: 47.35 E-value: 1.40e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1072240033 1450 CACPkgNSKSFSPTCVLEGiddFRCDaCLPGYEGKYCERCSLGYFGNPSDPDGSC 1504
Cdd:pfam00053 1 CDCN--PHGSLSDTCDPET---GQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
270-317 |
2.54e-06 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
:
Pssm-ID: 238012 Cd Length: 50 Bit Score: 46.58 E-value: 2.54e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1072240033 270 CICYGHA---RSCpwDEVTqkLQCQCERNTCGESCNECCPGYHQNPWRPGT 317
Cdd:cd00055 2 CDCNGHGslsGQC--DPGT--GQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LamNT |
smart00136 |
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ... |
16-268 |
5.93e-91 |
|
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.
Pssm-ID: 214532 Cd Length: 238 Bit Score: 295.81 E-value: 5.93e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 16 QCQLRGLFPAILNLASKADISTNATCGEMGPEMFCKLVEHVpgriDRNPQCRICDQNsvNAKERHPITNAIDGTND---- 91
Cdd:smart00136 1 AGRPRSCYPPFVNLAFGREVTATSTCGEPGPERYCKLVGHT----EQGKKCDYCDAR--NPRRSHPAENLTDGNNPnnpt 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 92 WWQSPSIQNGRlyHWITLTLDLKQVFQVAYVIIKAAnSPRPGNWILEHSFDGVEFMPWQYYAisdTECLTRYNITPRLGP 171
Cdd:smart00136 75 WWQSEPLSNGP--QNVNLTLDLGKEFHVTYVILKFC-SPRPSLWILERSDFGKTWQPWQYFS---SDCRRTFGRPPRGPI 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 172 PTYKrDDEVICTSYYSRLVPLEHGEIHTSLINGRPSADDP--SPTLLDFTSARYIRLRLQRIRTLNADLMTLShndlrnv 249
Cdd:smart00136 149 TKGN-EDEVICTSEYSDIVPLEGGEIAFSLLEGRPSATDFdnSPVLQEWVTATNIRVRLTRLRTLGDELMDDR------- 220
|
250
....*....|....*....
gi 1072240033 250 dPIVTRRYYYSIKDISVGG 268
Cdd:smart00136 221 -PEVTRRYYYAISDIAVGG 238
|
|
| Laminin_N |
pfam00055 |
Laminin N-terminal (Domain VI); |
22-268 |
2.18e-81 |
|
Laminin N-terminal (Domain VI);
Pssm-ID: 459653 Cd Length: 230 Bit Score: 268.30 E-value: 2.18e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 22 LFPAILNLASKADISTNATCGEMGPEMFCKLVEHVPGridrnPQCRICDqnSVNAKERHPITNAIDGTND----WWQSPS 97
Cdd:pfam00055 1 CYPAFGNLAFGREVSATSTCGLNGPERYCILSGLEGG-----KKCFICD--SRDPHNSHPPSNLTDSNNGtnetWWQSET 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 98 IQngRLYHWITLTLDLKQVFQVAYVIIKAAnSPRPGNWILEHSFD-GVEFMPWQYYAisdTECLTRYNITPRlgPPTYKR 176
Cdd:pfam00055 74 GV--IQYENVNLTLDLGKEFHFTYLILKFK-SPRPAAMVLERSTDfGKTWQPYQYFA---SDCRRTFGRPSG--PSRGIK 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 177 DDEVICTSYYSRLVPLEHGEIHTSLINGRPSA--DDPSPTLLDFTSARYIRLRLQRIRTLNADLMTlshndlrnvDPIVT 254
Cdd:pfam00055 146 DDEVICTSEYSDISPLTGGEVIFSTLEGRPSAniFDYSPELQDWLTATNIRIRLLRLHTLGDELLD---------DPSVL 216
|
250
....*....|....
gi 1072240033 255 RRYYYSIKDISVGG 268
Cdd:pfam00055 217 RKYYYAISDISVGG 230
|
|
| Laminin_B |
pfam00052 |
Laminin B (Domain IV); |
1216-1358 |
3.59e-43 |
|
Laminin B (Domain IV);
Pssm-ID: 459652 Cd Length: 136 Bit Score: 154.74 E-value: 3.59e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1216 YWKLPSQFLGEKTLAYGGMLKYVVTYYGLGESGPSDFEPHIIMKGGHLRKQVLYMAKPNPVNGVRTETQISFKEEDWKYH 1295
Cdd:pfam00052 1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGGSLNSEPDVILEGNGLRLSYSSPDQPPPDPGQEQTYSVRLHEENWRDS 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1072240033 1296 NSVsdeSVTRMDFMSVLSKLDYILIKASYGYGLQQSRISNISMDIAVEAAemhSGrEAANLIE 1358
Cdd:pfam00052 81 DGA---PVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSAVPGG---SG-PPASWVE 136
|
|
| Laminin_B |
pfam00052 |
Laminin B (Domain IV); |
566-705 |
1.42e-42 |
|
Laminin B (Domain IV);
Pssm-ID: 459652 Cd Length: 136 Bit Score: 153.19 E-value: 1.42e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 566 YWEAPSSYLGNKLTSYGGVLRYTVSYDIPVESldREPVSNVDLVMQGSGITIVTRTEGLL-LQPYEEHTAEIKLLPENFL 644
Cdd:pfam00052 1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGG--GSLNSEPDVILEGNGLRLSYSSPDQPpPDPGQEQTYSVRLHEENWR 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1072240033 645 DfYTNRPLDRDRLMTVLANINRLWIRATYNNDKNAVtRLSSVTLDTATPNVIDlLPAVQVE 705
Cdd:pfam00052 79 D-SDGAPVSREDFMMVLANLTAILIRATYSTGSGQV-SLSNVSLDSAVPGGSG-PPASWVE 136
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
2309-2465 |
1.03e-41 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 151.42 E-value: 1.03e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2309 SFYFDGSGY-SIVEKTMRSTTTQIVIHFRTFSPNGLLLYLASNGTRDFLSLEIVDGKLRLSVELGSGPLTLTTDGRYNDG 2387
Cdd:cd00110 1 GVSFSGSSYvRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDG 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1072240033 2388 NWYKVAFQRNKKQGILAVmDSYNSsqrenkqGEAPGTASDLNRSDKDPIYIGGLPRSRVVRRQLVSRSYVGCIRNLEI 2465
Cdd:cd00110 81 QWHSVSVERNGRSVTLSV-DGERV-------VESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
|
|
| Laminin_II |
pfam06009 |
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 ... |
2013-2147 |
3.50e-40 |
|
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.
Pssm-ID: 368703 [Multi-domain] Cd Length: 138 Bit Score: 146.48 E-value: 3.50e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2013 AKDLALSANTTAAGTLGHIMNFSQKLSNATSTLSRVNDTLQRTNVLLVDSSKAAVSAESRIKEVETQANILLDRLKPMKL 2092
Cdd:pfam06009 1 SKELAREANETAKEVLEQLAPLSQNLENTSEKLSGINRSLEETNELVNDANKALDDAGRSVKKLEELAPDLLDKLKPLKQ 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1072240033 2093 LEEN---LSRNLSEIKELINQARKQAASIKVAVSADRDCVRSYHPEIRSTNFNTLILN 2147
Cdd:pfam06009 81 LEVNsssLSDNISRIKELIAQARKAANSIKVSVSFDGDSIVELRPPISVTDLAAYTSL 138
|
|
| Laminin_G_1 |
pfam00054 |
Laminin G domain; |
2763-2891 |
1.44e-38 |
|
Laminin G domain;
Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 141.30 E-value: 1.44e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2763 RAYATSGLIYYMAHQNQMDYAALQLHDGKLHFLFDMGKGKTETIHPVLINDGKWHTISTEYIKRKSTITVDGQEATSTST 2842
Cdd:pfam00054 2 RTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGES 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2843 P-GESNSLDVEGKLYLGGLAPSYTAKNIGNVTHSIPACISNVSVNGKRLN 2891
Cdd:pfam00054 82 PlGATTDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
|
|
| LamB |
smart00281 |
Laminin B domain; |
561-693 |
2.08e-37 |
|
Laminin B domain;
Pssm-ID: 214597 Cd Length: 127 Bit Score: 137.78 E-value: 2.08e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 561 LHSVYYWEAPSSYLGNKLTSYGGVLRYTVSYDIPVESldrEPVSNVDLVMQGSGITIVTRTEGlLLQPYEEHTAEIKLLP 640
Cdd:smart00281 1 DNEPVYWVAPEQFLGDKVTSYGGKLRYTLSFDGRRGG---THVSAPDVILEGNGLRISHPAEG-PPLPDELTTVEVRFRE 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1072240033 641 ENFLDfYTNRPLDRDRLMTVLANINRLWIRATYnNDKNAVTRLSSVTLDTATP 693
Cdd:smart00281 77 ENWQY-YGGRPVTREDLMMVLANLTAILIRATY-SQQMAGSRLSDVSLEVAVP 127
|
|
| LamB |
smart00281 |
Laminin B domain; |
1215-1343 |
6.42e-37 |
|
Laminin B domain;
Pssm-ID: 214597 Cd Length: 127 Bit Score: 136.62 E-value: 6.42e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1215 FYWKLPSQFLGEKTLAYGGMLKYVVTYYGlGESGPSDFEPHIIMKGGHLRKQVLYMAKPNPVNGVRTetQISFKEEDWKY 1294
Cdd:smart00281 5 VYWVAPEQFLGDKVTSYGGKLRYTLSFDG-RRGGTHVSAPDVILEGNGLRISHPAEGPPLPDELTTV--EVRFREENWQY 81
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1072240033 1295 HNSvsdESVTRMDFMSVLSKLDYILIKASYGYGLQQSRISNISMDIAVE 1343
Cdd:smart00281 82 YGG---RPVTREDLMMVLANLTAILIRATYSQQMAGSRLSDVSLEVAVP 127
|
|
| LamG |
smart00282 |
Laminin G domain; |
2330-2467 |
8.48e-37 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 136.32 E-value: 8.48e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2330 QIVIHFRTFSPNGLLLYLASNGTRDFLSLEIVDGKLRLSVELGSGPLTLT-TDGRYNDGNWYKVAFQRNKKQGILAVmDS 2408
Cdd:smart00282 1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTsDPTPLNDGQWHRVAVERNGRSVTLSV-DG 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1072240033 2409 YNSSqrenkQGEAPGTASDLNRsdKDPIYIGGLPRSRVVRRQLVSRSYVGCIRNLEISR 2467
Cdd:smart00282 80 GNRV-----SGESPGGLTILNL--DGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNG 131
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
2911-3064 |
2.35e-36 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 136.01 E-value: 2.35e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2911 GTYFDGTGFAALVKEGYKvRFDLNISLEFRTTARNAVLLGISSA-KVDAIGLEIVNGRVLFHVNNGAGRITAIYKPeqan 2989
Cdd:cd00110 1 GVSFSGSSYVRLPTLPAP-RTRLSISFSFRTTSPNGLLLYAGSQnGGDFLALELEDGRLVLRYDLGSGSLVLSSKT---- 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1072240033 2990 SLCDGEWHQVNANKIKHKIVLKVDGNTILTDSPHVQSTSADTSNPVYVGGYPAGVKQNCLTSQTSFRGCIRNLKL 3064
Cdd:cd00110 76 PLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
|
|
| LamG |
smart00282 |
Laminin G domain; |
2757-2888 |
7.13e-33 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 125.14 E-value: 7.13e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2757 SVQLTLRAYATSGLIYYMAHQNQMDYAALQLHDGKLHFLFDMGKGKTE-TIHPVLINDGKWHTISTEYIKRKSTITVDGQ 2835
Cdd:smart00282 1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARlTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1072240033 2836 EATSTSTPGESNSLDVEGKLYLGGLAPSYTAKnIGNVTHSIPACISNVSVNGK 2888
Cdd:smart00282 81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLP-PLPVTPGFRGCIRNLKVNGK 132
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
2735-2886 |
5.05e-32 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 123.68 E-value: 5.05e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2735 FGLTTGSHMLLPFDQsAVRRKLSVQLTLRAYATSGLIYYMAHQNQMDYAALQLHDGKLHFLFDMGKGKTETIHPVLINDG 2814
Cdd:cd00110 2 VSFSGSSYVRLPTLP-APRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDG 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1072240033 2815 KWHTISTEYIKRKSTITVDGQEATSTSTPGESNSLDVEGKLYLGGLaPSYTAKNIGNVTHSIPACISNVSVN 2886
Cdd:cd00110 81 QWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGL-PEDLKSPGLPVSPGFVGCIRDLKVN 151
|
|
| LamG |
smart00282 |
Laminin G domain; |
2934-3064 |
5.62e-32 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 122.45 E-value: 5.62e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2934 NISLEFRTTARNAVLLGISSA-KVDAIGLEIVNGRVLFHVNNGAGRITAIYKPeqaNSLCDGEWHQVNANKIKHKIVLKV 3012
Cdd:smart00282 1 SISFSFRTTSPNGLLLYAGSKgGGDYLALELRDGRLVLRYDLGSGPARLTSDP---TPLNDGQWHRVAVERNGRSVTLSV 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1072240033 3013 DG-NTILTDSPHvQSTSADTSNPVYVGGYPAGVKQNCLTSQTSFRGCIRNLKL 3064
Cdd:smart00282 78 DGgNRVSGESPG-GLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKV 129
|
|
| Laminin_G_1 |
pfam00054 |
Laminin G domain; |
2335-2471 |
1.42e-30 |
|
Laminin G domain;
Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 118.57 E-value: 1.42e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2335 FRTFSPNGLLLYLASNGTRDFLSLEIVDGKLRLSVELGSGPLTLTTDGRYNDGNWYKVAFQRNKKQGILAVMDsynssqR 2414
Cdd:pfam00054 1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDG------E 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1072240033 2415 ENKQGEAP-GTASDLNRsdKDPIYIGGLPRSRVVRRQLV-SRSYVGCIRNLEISRSNFD 2471
Cdd:pfam00054 75 ARPTGESPlGATTDLDV--DGPLYVGGLPSLGVKKRRLAiSPSFDGCIRDVIVNGKPLD 131
|
|
| LamG |
smart00282 |
Laminin G domain; |
2143-2282 |
3.05e-30 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 117.83 E-value: 3.05e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2143 TLILNVKTSEPDNLLFYMGSNSKADFMAVEMRQGKVSLLWDLGTGATRLEDPGMQINNNKWHKIHATRFGRSGTLaveEV 2222
Cdd:smart00282 1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTL---SV 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2223 NTSQKTSTkpsSSPGTSSILHVDnsTLMFIGGIGGGLQRSPALQTTDFRGCMGEAFLNGK 2282
Cdd:smart00282 78 DGGNRVSG---ESPGGLTILNLD--GPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
|
|
| Laminin_I |
pfam06008 |
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ... |
1575-1821 |
3.91e-30 |
|
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.
Pssm-ID: 310534 [Multi-domain] Cd Length: 258 Bit Score: 121.75 E-value: 3.91e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1575 SINF-TGIVTVPHGFMTHLENMTMHVKDSVFTNSNKTQNLDQTVKQLNAVSADTVLLHNRLAQVKKHGFSVHNSTINTLN 1653
Cdd:pfam06008 3 SLNSlTGALPAPYKINYNLENLTKQLQEYLSPENAHKIQIEILEKELSSLAQETEELQKKATQTLAKAQQVNAESERTLG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1654 KSQELMGFIDKMQTTIKVLIEVAESLNEtlgSDALLPV----NYQEGVLSKLGELSTRSFSDHNQNAVENVKALDVLLSR 1729
Cdd:pfam06008 83 HAKELAEAIKNLIDNIKEINEKVATLGE---NDFALPSsdlsRMLAEAQRMLGEIRSRDFGTQLQNAEAELKAAQDLLSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1730 VQKEFGKPHDDLAKVKKSLENSLDQHTSKLLAAEDFIYESASNLNTTNNLLVVIQNNLEDFSVKKLNFQENKNRSVMLIE 1809
Cdd:pfam06008 160 IQTWFQSPQEENKALANALRDSLAEYEAKLSDLRELLREAAAKTRDANRLNLANQANLREFQRKKEEVSEQKNQLEETLK 239
|
250
....*....|..
gi 1072240033 1810 EGLGLVDEAVLL 1821
Cdd:pfam06008 240 TARDSLDAANLL 251
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
2131-2280 |
2.01e-28 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 113.28 E-value: 2.01e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2131 SYHPEIRSTNFNTLILNVKTSEPDNLLFYMGSNSKADFMAVEMRQGKVSLLWDLGTGATRLEDPGmQINNNKWHKIHATR 2210
Cdd:cd00110 11 RLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKT-PLNDGQWHSVSVER 89
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2211 FGRSGTLAVEevNTSQKTSTKPSSSPgtssilHVDNSTLMFIGGIGGGLQRSPALQTTDFRGCMGEAFLN 2280
Cdd:cd00110 90 NGRSVTLSVD--GERVVESGSPGGSA------LLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKVN 151
|
|
| Laminin_G_1 |
pfam00054 |
Laminin G domain; |
2148-2285 |
7.34e-28 |
|
Laminin G domain;
Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 110.87 E-value: 7.34e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2148 VKTSEPDNLLFYMGSNSKADFMAVEMRQGKVSLLWDLGTGATRLEdPGMQINNNKWHKIHATRFGRSGTLAV--EEVNTS 2225
Cdd:pfam00054 1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVR-SGDKLNDGKWHSVELERNGRSGTLSVdgEARPTG 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1072240033 2226 qktstkpSSSPGTSSILHVDnsTLMFIGGIGG-GLQRSPALQTTDFRGCMGEAFLNGKSIG 2285
Cdd:pfam00054 80 -------ESPLGATTDLDVD--GPLYVGGLPSlGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
|
|
| Laminin_G_1 |
pfam00054 |
Laminin G domain; |
2939-3064 |
5.52e-27 |
|
Laminin G domain;
Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 108.17 E-value: 5.52e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2939 FRTTARNAVLL-GISSAKVDAIGLEIVNGRVLFHVNNGAGRITAIYKPEqansLCDGEWHQVNANKIKHKIVLKVDGN-T 3016
Cdd:pfam00054 1 FRTTEPSGLLLyNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDK----LNDGKWHSVELERNGRSGTLSVDGEaR 76
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1072240033 3017 ILTDSPHVQSTSADTSNPVYVGGYP-AGVKQNCLTSQTSFRGCIRNLKL 3064
Cdd:pfam00054 77 PTGESPLGATTDLDVDGPLYVGGLPsLGVKKRRLAISPSFDGCIRDVIV 125
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
2490-2655 |
7.09e-26 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 105.96 E-value: 7.09e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2490 SITVLNDGYVEM-QPVSLSPESELMVSFSTLNDTGIILagfgkaaekRSRRQAQLPFFALMLINGHIELHINplDGASTr 2568
Cdd:cd00110 1 GVSFSGSSYVRLpTLPAPRTRLSISFSFRTTSPNGLLL---------YAGSQNGGDFLALELEDGRLVLRYD--LGSGS- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2569 kTVIRSPTgTYSDGQEHSIILLRNKRFVSVQVDEGKPAEVKLNGPSVDLVAINafRFFIGGVPGKMGATMLRTSQSFYGC 2648
Cdd:cd00110 69 -LVLSSKT-PLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDG--PLYLGGLPEDLKSPGLPVSPGFVGC 144
|
....*..
gi 1072240033 2649 IQNLILN 2655
Cdd:cd00110 145 IRDLKVN 151
|
|
| LamG |
smart00282 |
Laminin G domain; |
2511-2655 |
8.30e-24 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 99.34 E-value: 8.30e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2511 ELMVSFSTLNDTGIILagfgkaaekRSRRQAQLPFFALMLINGHIELHINpldgASTRKTVIRSPTGTYSDGQEHSIILL 2590
Cdd:smart00282 1 SISFSFRTTSPNGLLL---------YAGSKGGGDYLALELRDGRLVLRYD----LGSGPARLTSDPTPLNDGQWHRVAVE 67
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1072240033 2591 RNKRFVSVQVDEGKPAEVKLNGPSVDLVAINafRFFIGGVPGKMGATMLRTSQSFYGCIQNLILN 2655
Cdd:smart00282 68 RNGRSVTLSVDGGNRVSGESPGGLTILNLDG--PLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVN 130
|
|
| Laminin_G_1 |
pfam00054 |
Laminin G domain; |
2516-2660 |
5.72e-20 |
|
Laminin G domain;
Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 88.14 E-value: 5.72e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2516 FSTLNDTGIILAGfGKAAEKrsrrqaqlPFFALMLINGHIELHINPLDGAstrkTVIRSPTgTYSDGQEHSIILLRNKRF 2595
Cdd:pfam00054 1 FRTTEPSGLLLYN-GTQTER--------DFLALELRDGRLEVSYDLGSGA----AVVRSGD-KLNDGKWHSVELERNGRS 66
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1072240033 2596 VSVQVDEGKPAEV-KLNGPSVDLVAINAfrFFIGGVPG-KMGATMLRTSQSFYGCIQNLILNMEQLD 2660
Cdd:pfam00054 67 GTLSVDGEARPTGeSPLGATTDLDVDGP--LYVGGLPSlGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
900-946 |
3.05e-13 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 66.22 E-value: 3.05e-13
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1072240033 900 CECHPDSSISSMCHHDTGLCDCKPHVIGKKCDQCEPGFYGL--TSGLGC 946
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLpsDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
899-946 |
7.75e-13 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 65.07 E-value: 7.75e-13
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1072240033 899 ACECHPDSSISSMCHHDTGLCDCKPHVIGKKCDQCEPGFYGLTS-GLGC 946
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSqGGGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
900-946 |
3.49e-12 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 63.10 E-value: 3.49e-12
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1072240033 900 CECHPDSSISSMCHHDTGLCDCKPHVIGKKCDQCEPGFYGlTSGLGC 946
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYG-DGPPGC 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
739-787 |
3.57e-11 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 60.45 E-value: 3.57e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1072240033 739 PCDCNGHAT---DCD-IHGACYgCQHNTTGPHCDQCIPGFYGYPTAgtPQDCQ 787
Cdd:cd00055 1 PCDCNGHGSlsgQCDpGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQ--GGGCQ 50
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
740-786 |
1.77e-10 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 58.52 E-value: 1.77e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1072240033 740 CDCNGHAT---DCDIH-GACYgCQHNTTGPHCDQCIPGFYGYPTaGTPQDC 786
Cdd:pfam00053 1 CDCNPHGSlsdTCDPEtGQCL-CKPGVTGRHCDRCKPGYYGLPS-DPPQGC 49
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
397-454 |
1.84e-10 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 58.52 E-value: 1.84e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1072240033 397 CECDPFGSVSPVCVVDDnhstqgalpGQCPCKEGYTGTKCNQCAFGYKGYPHCVRCNC 454
Cdd:pfam00053 1 CDCNPHGSLSDTCDPET---------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
949-993 |
2.13e-10 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 58.09 E-value: 2.13e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1072240033 949 CNCSLSGSNSGVCD-DAGQCPCVSGVAGVKCDVCAQGFYGYEDGGC 993
Cdd:smart00180 1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
452-498 |
2.41e-10 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 58.13 E-value: 2.41e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1072240033 452 CNCSLIGSLND--DPCADQCICKEHVEGENCDRCKSGFYNLQEKNPEGC 498
Cdd:pfam00053 1 CDCNPHGSLSDtcDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1507-1541 |
3.24e-10 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 57.75 E-value: 3.24e-10
10 20 30
....*....|....*....|....*....|....*
gi 1072240033 1507 CDCNPSGSLHNHCDRITGQCVCKVGVTGRLCDTCE 1541
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCK 35
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
846-898 |
3.66e-10 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 57.36 E-value: 3.66e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1072240033 846 PCDCNGNIDpfEDGHCDSVTGECLkCIGNTAGRYCERCADGFHGDAIFVKNCT 898
Cdd:cd00055 1 PCDCNGHGS--LSGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1507-1554 |
4.49e-10 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 57.36 E-value: 4.49e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1072240033 1507 CDCNPSGSLHNHCDRITGQCVCKVGVTGRLCDTCEVRHTLLEQQCISC 1554
Cdd:cd00055 2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1507-1541 |
8.07e-10 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 56.55 E-value: 8.07e-10
10 20 30
....*....|....*....|....*....|....*
gi 1072240033 1507 CDCNPSGSLHNHCDRITGQCVCKVGVTGRLCDTCE 1541
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCA 35
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1042-1090 |
8.69e-10 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 56.59 E-value: 8.69e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1072240033 1042 CNCSTDGSSSLQCDLTTGQCLCRKEFAGQTCNTCLFGYRKYPSCISCDC 1090
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
396-447 |
1.37e-09 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 55.82 E-value: 1.37e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1072240033 396 PCECDPFGSVSPVCVVDDnhstqgalpGQCPCKEGYTGTKCNQCAFGYKGYP 447
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGT---------GQCECKPNTTGRRCDRCAPGYYGLP 43
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
847-892 |
2.10e-09 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 55.44 E-value: 2.10e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1072240033 847 CDCNGNIDPfeDGHCDSVTGECLkCIGNTAGRYCERCADGFHGDAI 892
Cdd:pfam00053 1 CDCNPHGSL--SDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPS 43
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
397-447 |
5.44e-09 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 54.24 E-value: 5.44e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1072240033 397 CECDPFGSVSPVCVVDDnhstqgalpGQCPCKEGYTGTKCNQCAFGYKGYP 447
Cdd:smart00180 1 CDCDPGGSASGTCDPDT---------GQCECKPNVTGRRCDRCAPGYYGDG 42
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
451-499 |
6.06e-09 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 53.90 E-value: 6.06e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1072240033 451 RCNCSLIGSLND--DPCADQCICKEHVEGENCDRCKSGFYNLQEkNPEGCT 499
Cdd:cd00055 1 PCDCNGHGSLSGqcDPGTGQCECKPNTTGRRCDRCAPGYYGLPS-QGGGCQ 50
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
949-996 |
7.06e-09 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 53.90 E-value: 7.06e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1072240033 949 CNCSLSGSNSGVCD-DAGQCPCVSGVAGVKCDVCAQGFYGYEDGGCTAC 996
Cdd:pfam00053 1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
452-498 |
7.82e-09 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 53.47 E-value: 7.82e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1072240033 452 CNCSLIGSLND--DPCADQCICKEHVEGENCDRCKSGFYNlqeKNPEGC 498
Cdd:smart00180 1 CDCDPGGSASGtcDPDTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
948-992 |
2.34e-08 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 52.36 E-value: 2.34e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1072240033 948 PCNCSLSGSNSGVCD-DAGQCPCVSGVAGVKCDVCAQGFYGYEDGG 992
Cdd:cd00055 1 PCDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1042-1084 |
2.41e-08 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 52.36 E-value: 2.41e-08
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1072240033 1042 CNCSTDGSSSLQCDLTTGQCLCRKEFAGQTCNTCLFGYRKYPS 1084
Cdd:cd00055 2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS 44
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1042-1079 |
4.93e-08 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 51.54 E-value: 4.93e-08
10 20 30
....*....|....*....|....*....|....*...
gi 1072240033 1042 CNCSTDGSSSLQCDLTTGQCLCRKEFAGQTCNTCLFGY 1079
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGY 38
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1401-1447 |
6.71e-08 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 51.20 E-value: 6.71e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1401 CQCSNH---SEICDPDTGECLgCTDNTAGHHCHVCASGYYGKVAGSITDC 1447
Cdd:pfam00053 1 CDCNPHgslSDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
740-781 |
7.58e-08 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 50.77 E-value: 7.58e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1072240033 740 CDCN--GHATD-CD-IHGACYgCQHNTTGPHCDQCIPGFYGYPTAG 781
Cdd:smart00180 1 CDCDpgGSASGtCDpDTGQCE-CKPNVTGRRCDRCAPGYYGDGPPG 45
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
996-1039 |
1.07e-07 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 50.43 E-value: 1.07e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1072240033 996 CDCEH---TQNNCNPQTGECICPPHTHGSKCEFCKANYWG--HDPELGC 1039
Cdd:pfam00053 1 CDCNPhgsLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGlpSDPPQGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
996-1039 |
1.90e-07 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 49.62 E-value: 1.90e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1072240033 996 CDCE---HTQNNCNPQTGECICPPHTHGSKCEFCKANYWGHDPElGC 1039
Cdd:smart00180 1 CDCDpggSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPP-GC 46
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1088-1145 |
3.28e-07 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 49.27 E-value: 3.28e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1072240033 1088 CDCDVKGTQSAWCDdeqkmcscgEETGNCACKDNVIGSYCNECKGGTFALHGENPLGC 1145
Cdd:pfam00053 1 CDCNPHGSLSDTCD---------PETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
995-1039 |
3.71e-07 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 48.89 E-value: 3.71e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1072240033 995 ACDCEHT---QNNCNPQTGECICPPHTHGSKCEFCKANYWGHDPE-LGC 1039
Cdd:cd00055 1 PCDCNGHgslSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQgGGC 49
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
789-844 |
4.72e-07 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 48.89 E-value: 4.72e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1072240033 789 CACPLNAPSnnfSPTCYLSGeedVICdQCAPGYTGPRCEKCANGYYGNPSVLGGSC 844
Cdd:pfam00053 1 CDCNPHGSL---SDTCDPET---GQC-LCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1400-1438 |
6.82e-07 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 48.12 E-value: 6.82e-07
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1072240033 1400 PCQCSNH---SEICDPDTGECLgCTDNTAGHHCHVCASGYYG 1438
Cdd:cd00055 1 PCDCNGHgslSGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYG 41
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1450-1504 |
1.40e-06 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 47.35 E-value: 1.40e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1072240033 1450 CACPkgNSKSFSPTCVLEGiddFRCDaCLPGYEGKYCERCSLGYFGNPSDPDGSC 1504
Cdd:pfam00053 1 CDCN--PHGSLSDTCDPET---GQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
847-890 |
1.91e-06 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 46.92 E-value: 1.91e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1072240033 847 CDCN--GNIDPfedgHCDSVTGECLkCIGNTAGRYCERCADGFHGD 890
Cdd:smart00180 1 CDCDpgGSASG----TCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD 41
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
270-317 |
2.54e-06 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 46.58 E-value: 2.54e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1072240033 270 CICYGHA---RSCpwDEVTqkLQCQCERNTCGESCNECCPGYHQNPWRPGT 317
Cdd:cd00055 2 CDCNGHGslsGQC--DPGT--GQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
|
|
| 235kDa-fam |
TIGR01612 |
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ... |
1575-2183 |
3.61e-06 |
|
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.
Pssm-ID: 130673 [Multi-domain] Cd Length: 2757 Bit Score: 53.13 E-value: 3.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1575 SINFTGIVTVPHGFMTHLENMTMHVKDSVFTNSNKTQNLDQTVKQ-LNAVSADTVLLHNRL-AQVKKHGFSVH------- 1645
Cdd:TIGR01612 816 SKEYIKTISIKEDEIFKIINEMKFMKDDFLNKVDKFINFENNCKEkIDSEHEQFAELTNKIkAEISDDKLNDYekkfnds 895
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1646 NSTINTLNKSQEL----MGFIDKMQTTIKVLIEVAES----------LNETLGS--DALLPVN---------YQEGVLSK 1700
Cdd:TIGR01612 896 KSLINEINKSIEEeyqnINTLKKVDEYIKICENTKESiekfhnkqniLKEILNKniDTIKESNlieksykdkFDNTLIDK 975
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1701 LGELStRSFSDHNQNAVE-NVKALDVLLSRVQKEFGKPH--------DDLAKVKKSLENSLDQHTSKLLAAEDFIYESAS 1771
Cdd:TIGR01612 976 INELD-KAFKDASLNDYEaKNNELIKYFNDLKANLGKNKenmlyhqfDEKEKATNDIEQKIEDANKNIPNIEIAIHTSIY 1054
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1772 NLNTT------NNLLVVIQNNLEDFSVKKLNFQENK------NRSVMLIEEGLGLVDEAVLLAEDTINATSVLEMHQEEL 1839
Cdd:TIGR01612 1055 NIIDEiekeigKNIELLNKEILEEAEINITNFNEIKeklkhyNFDDFGKEENIKYADEINKIKDDIKNLDQKIDHHIKAL 1134
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1840 IMWNTKLRHHVDELVMQMSK-RDALDLAYNSEDhaaallrlsdslnssLSDVRNTSFNATNAIQAHSNI-----KRMVEQ 1913
Cdd:TIGR01612 1135 EEIKKKSENYIDEIKAQINDlEDVADKAISNDD---------------PEEIEKKIENIVTKIDKKKNIydeikKLLNEI 1199
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1914 AEVLAEQSNYtisETVRLVSGPNGSLVGTskdslMFSSQlVNESKNLSRNT----EGLVSHLNGLKTKVDEIQKRTRVfT 1989
Cdd:TIGR01612 1200 AEIEKDKTSL---EEVKGINLSYGKNLGK-----LFLEK-IDEEKKKSEHMikamEAYIEDLDEIKEKSPEIENEMGI-E 1269
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1990 GQINEQLRSLrslpNDTSSKLQEAKDLALSANTtaagTLGHIMNFSQKLSNATSTLSRVNDTLQRTNVLLVDSSKAAVSA 2069
Cdd:TIGR01612 1270 MDIKAEMETF----NISHDDDKDHHIISKKHDE----NISDIREKSLKIIEDFSEESDINDIKKELQKNLLDAQKHNSDI 1341
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2070 ESRIKEVETQANIL-LDRLKPM----KLLEENLSRNLSEIKELINQARKQAASIKVAVSAdRDCVRSYHPEIRSTNFNTL 2144
Cdd:TIGR01612 1342 NLYLNEIANIYNILkLNKIKKIidevKEYTKEIEENNKNIKDELDKSEKLIKKIKDDINL-EECKSKIESTLDDKDIDEC 1420
|
650 660 670
....*....|....*....|....*....|....*....
gi 1072240033 2145 ILNVKTSEpdNLLFYMGSNSKADFMAVEMRQGKVSLLWD 2183
Cdd:TIGR01612 1421 IKKIKELK--NHILSEESNIDTYFKNADENNENVLLLFK 1457
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
804-842 |
1.39e-05 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 44.65 E-value: 1.39e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1072240033 804 CYLSGEEDVICDQ------CAPGYTGPRCEKCANGYYGNPSVLGG 842
Cdd:cd00055 4 CNGHGSLSGQCDPgtgqceCKPNTTGRRCDRCAPGYYGLPSQGGG 48
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
789-837 |
1.53e-05 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 44.22 E-value: 1.53e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1072240033 789 CACPlnaPSNNFSPTCYLsgeEDVICdQCAPGYTGPRCEKCANGYYGNP 837
Cdd:smart00180 1 CDCD---PGGSASGTCDP---DTGQC-ECKPNVTGRRCDRCAPGYYGDG 42
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1401-1443 |
2.59e-05 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 43.84 E-value: 2.59e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1072240033 1401 CQCS---NHSEICDPDTGECLgCTDNTAGHHCHVCASGYYGKVAGS 1443
Cdd:smart00180 1 CDCDpggSASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGDGPPG 45
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1088-1145 |
3.66e-05 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 43.45 E-value: 3.66e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1072240033 1088 CDCDVKGTQSAWCDdeqkmcscgEETGNCACKDNVIGSYCNECKGGTFalhGENPLGC 1145
Cdd:smart00180 1 CDCDPGGSASGTCD---------PDTGQCECKPNVTGRRCDRCAPGYY---GDGPPGC 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1087-1145 |
2.75e-04 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 40.80 E-value: 2.75e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1072240033 1087 SCDCDVKGTQSAWCDDEqkmcscgeeTGNCACKDNVIGSYCNECKGGTFALhGENPLGC 1145
Cdd:cd00055 1 PCDCNGHGSLSGQCDPG---------TGQCECKPNTTGRRCDRCAPGYYGL-PSQGGGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1450-1505 |
5.01e-04 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 40.03 E-value: 5.01e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1072240033 1450 CACPKGNSKSfsPTCVLEgidDFRCDaCLPGYEGKYCERCSLGYFGNPSDPDGsCQ 1505
Cdd:cd00055 2 CDCNGHGSLS--GQCDPG---TGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGG-CQ 50
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1450-1497 |
7.94e-04 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 39.60 E-value: 7.94e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1072240033 1450 CACPKGNSksFSPTCVLegiDDFRCDaCLPGYEGKYCERCSLGYFGNP 1497
Cdd:smart00180 1 CDCDPGGS--ASGTCDP---DTGQCE-CKPNVTGRRCDRCAPGYYGDG 42
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
1953-2119 |
8.56e-04 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 45.05 E-value: 8.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1953 LVNESKNLSRNTEGLVSHLNGLKTKVDEIQKRTRVFTGQINEqlrsLRSLPNDTSSKLQEAKDLALSANTTAAGTLGHIM 2032
Cdd:TIGR02168 230 LVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEE----LRLEVSELEEEIEELQKELYALANEISRLEQQKQ 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2033 NFSQKLSNATSTLSRVNDTLQRTNVLLVDSSKAAVSAESRIKEVETQANILLDRLKPMKLLEENLSRNLSEIKELINQAR 2112
Cdd:TIGR02168 306 ILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLR 385
|
....*..
gi 1072240033 2113 KQAASIK 2119
Cdd:TIGR02168 386 SKVAQLE 392
|
|
| TNFRSF4 |
cd13406 |
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40; ... |
814-963 |
1.04e-03 |
|
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40; TNFRSF4 (also known as OX40, ACT35, CD134, IMD16, TXGP1L) activates NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. It also promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. It is primarily expressed on activated CD4+ and CD8+ T cells, where it is transiently expressed and upregulated on the most recently antigen-activated T cells within inflammatory lesions. This makes it an attractive target to modulate immune responses, i.e. TNFRSF4 (OX40) blocking agents to inhibit adverse inflammation or agonists to enhance immune responses. An artificially created biologic fusion protein, OX40-immunoglobulin (OX40-Ig), prevents OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Some single nucleotide polymorphisms (SNPs) of its natural ligand OX40 ligand (OX40L, CD252), which is also found on activated T cells, have been associated with systemic lupus erythematosus.
Pssm-ID: 276911 [Multi-domain] Cd Length: 142 Bit Score: 42.00 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 814 CDQCAPGY---------TGPRCEKCANGYYgNPSVLGGSCVPCDcngnidpfedgHCDSVTGECLKcigntagRYCERCA 884
Cdd:cd13406 15 CHECPPGEgmesrctgtQDTVCSPCEPGFY-NEAVNYEPCKPCT-----------QCNQRSGSEEK-------QKCTKTS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 885 DgfhgdaifvkncTACECHPdssiSSMCHHDtglcdckpHVIGKKCDQCEPGFYGLTSGLGCLP-CNCSLSG-------- 955
Cdd:cd13406 76 D------------TVCRCRP----GTQPLDS--------YKPGVDCVPCPPGHFSRGDNQACKPwTNCSLAGkrtlrpgs 131
|
....*....
gi 1072240033 956 -SNSGVCDD 963
Cdd:cd13406 132 sTSDAVCED 140
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
1972-2119 |
1.27e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 44.12 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1972 NGLKTKVDEIQKRTRVFT-GQINEQLRSLRSLPNDTSSKLQEAKdlalsanttaagtlghimnfsQKLSNATSTLSRVND 2050
Cdd:COG4372 22 TGILIAALSEQLRKALFElDKLQEELEQLREELEQAREELEQLE---------------------EELEQARSELEQLEE 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1072240033 2051 TLQRTNVLLVDSSKAAVSAESRIKEVETQANILLDRL----KPMKLLEENLSRNLSEIKELINQARKQAASIK 2119
Cdd:COG4372 81 ELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELeelqKERQDLEQQRKQLEAQIAELQSEIAEREEELK 153
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
289-313 |
4.77e-03 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 37.29 E-value: 4.77e-03
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LamNT |
smart00136 |
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ... |
16-268 |
5.93e-91 |
|
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.
Pssm-ID: 214532 Cd Length: 238 Bit Score: 295.81 E-value: 5.93e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 16 QCQLRGLFPAILNLASKADISTNATCGEMGPEMFCKLVEHVpgriDRNPQCRICDQNsvNAKERHPITNAIDGTND---- 91
Cdd:smart00136 1 AGRPRSCYPPFVNLAFGREVTATSTCGEPGPERYCKLVGHT----EQGKKCDYCDAR--NPRRSHPAENLTDGNNPnnpt 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 92 WWQSPSIQNGRlyHWITLTLDLKQVFQVAYVIIKAAnSPRPGNWILEHSFDGVEFMPWQYYAisdTECLTRYNITPRLGP 171
Cdd:smart00136 75 WWQSEPLSNGP--QNVNLTLDLGKEFHVTYVILKFC-SPRPSLWILERSDFGKTWQPWQYFS---SDCRRTFGRPPRGPI 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 172 PTYKrDDEVICTSYYSRLVPLEHGEIHTSLINGRPSADDP--SPTLLDFTSARYIRLRLQRIRTLNADLMTLShndlrnv 249
Cdd:smart00136 149 TKGN-EDEVICTSEYSDIVPLEGGEIAFSLLEGRPSATDFdnSPVLQEWVTATNIRVRLTRLRTLGDELMDDR------- 220
|
250
....*....|....*....
gi 1072240033 250 dPIVTRRYYYSIKDISVGG 268
Cdd:smart00136 221 -PEVTRRYYYAISDIAVGG 238
|
|
| Laminin_N |
pfam00055 |
Laminin N-terminal (Domain VI); |
22-268 |
2.18e-81 |
|
Laminin N-terminal (Domain VI);
Pssm-ID: 459653 Cd Length: 230 Bit Score: 268.30 E-value: 2.18e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 22 LFPAILNLASKADISTNATCGEMGPEMFCKLVEHVPGridrnPQCRICDqnSVNAKERHPITNAIDGTND----WWQSPS 97
Cdd:pfam00055 1 CYPAFGNLAFGREVSATSTCGLNGPERYCILSGLEGG-----KKCFICD--SRDPHNSHPPSNLTDSNNGtnetWWQSET 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 98 IQngRLYHWITLTLDLKQVFQVAYVIIKAAnSPRPGNWILEHSFD-GVEFMPWQYYAisdTECLTRYNITPRlgPPTYKR 176
Cdd:pfam00055 74 GV--IQYENVNLTLDLGKEFHFTYLILKFK-SPRPAAMVLERSTDfGKTWQPYQYFA---SDCRRTFGRPSG--PSRGIK 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 177 DDEVICTSYYSRLVPLEHGEIHTSLINGRPSA--DDPSPTLLDFTSARYIRLRLQRIRTLNADLMTlshndlrnvDPIVT 254
Cdd:pfam00055 146 DDEVICTSEYSDISPLTGGEVIFSTLEGRPSAniFDYSPELQDWLTATNIRIRLLRLHTLGDELLD---------DPSVL 216
|
250
....*....|....
gi 1072240033 255 RRYYYSIKDISVGG 268
Cdd:pfam00055 217 RKYYYAISDISVGG 230
|
|
| Laminin_B |
pfam00052 |
Laminin B (Domain IV); |
1216-1358 |
3.59e-43 |
|
Laminin B (Domain IV);
Pssm-ID: 459652 Cd Length: 136 Bit Score: 154.74 E-value: 3.59e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1216 YWKLPSQFLGEKTLAYGGMLKYVVTYYGLGESGPSDFEPHIIMKGGHLRKQVLYMAKPNPVNGVRTETQISFKEEDWKYH 1295
Cdd:pfam00052 1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGGSLNSEPDVILEGNGLRLSYSSPDQPPPDPGQEQTYSVRLHEENWRDS 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1072240033 1296 NSVsdeSVTRMDFMSVLSKLDYILIKASYGYGLQQSRISNISMDIAVEAAemhSGrEAANLIE 1358
Cdd:pfam00052 81 DGA---PVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSAVPGG---SG-PPASWVE 136
|
|
| Laminin_B |
pfam00052 |
Laminin B (Domain IV); |
566-705 |
1.42e-42 |
|
Laminin B (Domain IV);
Pssm-ID: 459652 Cd Length: 136 Bit Score: 153.19 E-value: 1.42e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 566 YWEAPSSYLGNKLTSYGGVLRYTVSYDIPVESldREPVSNVDLVMQGSGITIVTRTEGLL-LQPYEEHTAEIKLLPENFL 644
Cdd:pfam00052 1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGG--GSLNSEPDVILEGNGLRLSYSSPDQPpPDPGQEQTYSVRLHEENWR 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1072240033 645 DfYTNRPLDRDRLMTVLANINRLWIRATYNNDKNAVtRLSSVTLDTATPNVIDlLPAVQVE 705
Cdd:pfam00052 79 D-SDGAPVSREDFMMVLANLTAILIRATYSTGSGQV-SLSNVSLDSAVPGGSG-PPASWVE 136
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
2309-2465 |
1.03e-41 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 151.42 E-value: 1.03e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2309 SFYFDGSGY-SIVEKTMRSTTTQIVIHFRTFSPNGLLLYLASNGTRDFLSLEIVDGKLRLSVELGSGPLTLTTDGRYNDG 2387
Cdd:cd00110 1 GVSFSGSSYvRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDG 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1072240033 2388 NWYKVAFQRNKKQGILAVmDSYNSsqrenkqGEAPGTASDLNRSDKDPIYIGGLPRSRVVRRQLVSRSYVGCIRNLEI 2465
Cdd:cd00110 81 QWHSVSVERNGRSVTLSV-DGERV-------VESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
|
|
| Laminin_II |
pfam06009 |
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 ... |
2013-2147 |
3.50e-40 |
|
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.
Pssm-ID: 368703 [Multi-domain] Cd Length: 138 Bit Score: 146.48 E-value: 3.50e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2013 AKDLALSANTTAAGTLGHIMNFSQKLSNATSTLSRVNDTLQRTNVLLVDSSKAAVSAESRIKEVETQANILLDRLKPMKL 2092
Cdd:pfam06009 1 SKELAREANETAKEVLEQLAPLSQNLENTSEKLSGINRSLEETNELVNDANKALDDAGRSVKKLEELAPDLLDKLKPLKQ 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1072240033 2093 LEEN---LSRNLSEIKELINQARKQAASIKVAVSADRDCVRSYHPEIRSTNFNTLILN 2147
Cdd:pfam06009 81 LEVNsssLSDNISRIKELIAQARKAANSIKVSVSFDGDSIVELRPPISVTDLAAYTSL 138
|
|
| Laminin_G_1 |
pfam00054 |
Laminin G domain; |
2763-2891 |
1.44e-38 |
|
Laminin G domain;
Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 141.30 E-value: 1.44e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2763 RAYATSGLIYYMAHQNQMDYAALQLHDGKLHFLFDMGKGKTETIHPVLINDGKWHTISTEYIKRKSTITVDGQEATSTST 2842
Cdd:pfam00054 2 RTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGES 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2843 P-GESNSLDVEGKLYLGGLAPSYTAKNIGNVTHSIPACISNVSVNGKRLN 2891
Cdd:pfam00054 82 PlGATTDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
|
|
| LamB |
smart00281 |
Laminin B domain; |
561-693 |
2.08e-37 |
|
Laminin B domain;
Pssm-ID: 214597 Cd Length: 127 Bit Score: 137.78 E-value: 2.08e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 561 LHSVYYWEAPSSYLGNKLTSYGGVLRYTVSYDIPVESldrEPVSNVDLVMQGSGITIVTRTEGlLLQPYEEHTAEIKLLP 640
Cdd:smart00281 1 DNEPVYWVAPEQFLGDKVTSYGGKLRYTLSFDGRRGG---THVSAPDVILEGNGLRISHPAEG-PPLPDELTTVEVRFRE 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1072240033 641 ENFLDfYTNRPLDRDRLMTVLANINRLWIRATYnNDKNAVTRLSSVTLDTATP 693
Cdd:smart00281 77 ENWQY-YGGRPVTREDLMMVLANLTAILIRATY-SQQMAGSRLSDVSLEVAVP 127
|
|
| LamB |
smart00281 |
Laminin B domain; |
1215-1343 |
6.42e-37 |
|
Laminin B domain;
Pssm-ID: 214597 Cd Length: 127 Bit Score: 136.62 E-value: 6.42e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1215 FYWKLPSQFLGEKTLAYGGMLKYVVTYYGlGESGPSDFEPHIIMKGGHLRKQVLYMAKPNPVNGVRTetQISFKEEDWKY 1294
Cdd:smart00281 5 VYWVAPEQFLGDKVTSYGGKLRYTLSFDG-RRGGTHVSAPDVILEGNGLRISHPAEGPPLPDELTTV--EVRFREENWQY 81
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1072240033 1295 HNSvsdESVTRMDFMSVLSKLDYILIKASYGYGLQQSRISNISMDIAVE 1343
Cdd:smart00281 82 YGG---RPVTREDLMMVLANLTAILIRATYSQQMAGSRLSDVSLEVAVP 127
|
|
| LamG |
smart00282 |
Laminin G domain; |
2330-2467 |
8.48e-37 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 136.32 E-value: 8.48e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2330 QIVIHFRTFSPNGLLLYLASNGTRDFLSLEIVDGKLRLSVELGSGPLTLT-TDGRYNDGNWYKVAFQRNKKQGILAVmDS 2408
Cdd:smart00282 1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTsDPTPLNDGQWHRVAVERNGRSVTLSV-DG 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1072240033 2409 YNSSqrenkQGEAPGTASDLNRsdKDPIYIGGLPRSRVVRRQLVSRSYVGCIRNLEISR 2467
Cdd:smart00282 80 GNRV-----SGESPGGLTILNL--DGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNG 131
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
2911-3064 |
2.35e-36 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 136.01 E-value: 2.35e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2911 GTYFDGTGFAALVKEGYKvRFDLNISLEFRTTARNAVLLGISSA-KVDAIGLEIVNGRVLFHVNNGAGRITAIYKPeqan 2989
Cdd:cd00110 1 GVSFSGSSYVRLPTLPAP-RTRLSISFSFRTTSPNGLLLYAGSQnGGDFLALELEDGRLVLRYDLGSGSLVLSSKT---- 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1072240033 2990 SLCDGEWHQVNANKIKHKIVLKVDGNTILTDSPHVQSTSADTSNPVYVGGYPAGVKQNCLTSQTSFRGCIRNLKL 3064
Cdd:cd00110 76 PLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
|
|
| LamG |
smart00282 |
Laminin G domain; |
2757-2888 |
7.13e-33 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 125.14 E-value: 7.13e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2757 SVQLTLRAYATSGLIYYMAHQNQMDYAALQLHDGKLHFLFDMGKGKTE-TIHPVLINDGKWHTISTEYIKRKSTITVDGQ 2835
Cdd:smart00282 1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARlTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1072240033 2836 EATSTSTPGESNSLDVEGKLYLGGLAPSYTAKnIGNVTHSIPACISNVSVNGK 2888
Cdd:smart00282 81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLP-PLPVTPGFRGCIRNLKVNGK 132
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
2735-2886 |
5.05e-32 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 123.68 E-value: 5.05e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2735 FGLTTGSHMLLPFDQsAVRRKLSVQLTLRAYATSGLIYYMAHQNQMDYAALQLHDGKLHFLFDMGKGKTETIHPVLINDG 2814
Cdd:cd00110 2 VSFSGSSYVRLPTLP-APRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDG 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1072240033 2815 KWHTISTEYIKRKSTITVDGQEATSTSTPGESNSLDVEGKLYLGGLaPSYTAKNIGNVTHSIPACISNVSVN 2886
Cdd:cd00110 81 QWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGL-PEDLKSPGLPVSPGFVGCIRDLKVN 151
|
|
| LamG |
smart00282 |
Laminin G domain; |
2934-3064 |
5.62e-32 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 122.45 E-value: 5.62e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2934 NISLEFRTTARNAVLLGISSA-KVDAIGLEIVNGRVLFHVNNGAGRITAIYKPeqaNSLCDGEWHQVNANKIKHKIVLKV 3012
Cdd:smart00282 1 SISFSFRTTSPNGLLLYAGSKgGGDYLALELRDGRLVLRYDLGSGPARLTSDP---TPLNDGQWHRVAVERNGRSVTLSV 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1072240033 3013 DG-NTILTDSPHvQSTSADTSNPVYVGGYPAGVKQNCLTSQTSFRGCIRNLKL 3064
Cdd:smart00282 78 DGgNRVSGESPG-GLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKV 129
|
|
| Laminin_G_1 |
pfam00054 |
Laminin G domain; |
2335-2471 |
1.42e-30 |
|
Laminin G domain;
Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 118.57 E-value: 1.42e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2335 FRTFSPNGLLLYLASNGTRDFLSLEIVDGKLRLSVELGSGPLTLTTDGRYNDGNWYKVAFQRNKKQGILAVMDsynssqR 2414
Cdd:pfam00054 1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDG------E 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1072240033 2415 ENKQGEAP-GTASDLNRsdKDPIYIGGLPRSRVVRRQLV-SRSYVGCIRNLEISRSNFD 2471
Cdd:pfam00054 75 ARPTGESPlGATTDLDV--DGPLYVGGLPSLGVKKRRLAiSPSFDGCIRDVIVNGKPLD 131
|
|
| LamG |
smart00282 |
Laminin G domain; |
2143-2282 |
3.05e-30 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 117.83 E-value: 3.05e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2143 TLILNVKTSEPDNLLFYMGSNSKADFMAVEMRQGKVSLLWDLGTGATRLEDPGMQINNNKWHKIHATRFGRSGTLaveEV 2222
Cdd:smart00282 1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTL---SV 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2223 NTSQKTSTkpsSSPGTSSILHVDnsTLMFIGGIGGGLQRSPALQTTDFRGCMGEAFLNGK 2282
Cdd:smart00282 78 DGGNRVSG---ESPGGLTILNLD--GPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
|
|
| Laminin_I |
pfam06008 |
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ... |
1575-1821 |
3.91e-30 |
|
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.
Pssm-ID: 310534 [Multi-domain] Cd Length: 258 Bit Score: 121.75 E-value: 3.91e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1575 SINF-TGIVTVPHGFMTHLENMTMHVKDSVFTNSNKTQNLDQTVKQLNAVSADTVLLHNRLAQVKKHGFSVHNSTINTLN 1653
Cdd:pfam06008 3 SLNSlTGALPAPYKINYNLENLTKQLQEYLSPENAHKIQIEILEKELSSLAQETEELQKKATQTLAKAQQVNAESERTLG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1654 KSQELMGFIDKMQTTIKVLIEVAESLNEtlgSDALLPV----NYQEGVLSKLGELSTRSFSDHNQNAVENVKALDVLLSR 1729
Cdd:pfam06008 83 HAKELAEAIKNLIDNIKEINEKVATLGE---NDFALPSsdlsRMLAEAQRMLGEIRSRDFGTQLQNAEAELKAAQDLLSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1730 VQKEFGKPHDDLAKVKKSLENSLDQHTSKLLAAEDFIYESASNLNTTNNLLVVIQNNLEDFSVKKLNFQENKNRSVMLIE 1809
Cdd:pfam06008 160 IQTWFQSPQEENKALANALRDSLAEYEAKLSDLRELLREAAAKTRDANRLNLANQANLREFQRKKEEVSEQKNQLEETLK 239
|
250
....*....|..
gi 1072240033 1810 EGLGLVDEAVLL 1821
Cdd:pfam06008 240 TARDSLDAANLL 251
|
|
| Laminin_G_2 |
pfam02210 |
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
2335-2465 |
2.51e-29 |
|
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.
Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 114.82 E-value: 2.51e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2335 FRTFSPNGLLLYlASNGTRDFLSLEIVDGKLRLSVELGSGPLTLT-TDGRYNDGNWYKVAFQRNKKQGILAVmDSYNSSQ 2413
Cdd:pfam02210 1 FRTRQPNGLLLY-AGGGGSDFLALELVNGRLVLRYDLGSGPESLLsSGKNLNDGQWHSVRVERNGNTLTLSV-DGQTVVS 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1072240033 2414 RENkqgeaPGTASDLNrsDKDPIYIGGLPRSRVVRRQLVSRSYVGCIRNLEI 2465
Cdd:pfam02210 79 SLP-----PGESLLLN--LNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
2131-2280 |
2.01e-28 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 113.28 E-value: 2.01e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2131 SYHPEIRSTNFNTLILNVKTSEPDNLLFYMGSNSKADFMAVEMRQGKVSLLWDLGTGATRLEDPGmQINNNKWHKIHATR 2210
Cdd:cd00110 11 RLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKT-PLNDGQWHSVSVER 89
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2211 FGRSGTLAVEevNTSQKTSTKPSSSPgtssilHVDNSTLMFIGGIGGGLQRSPALQTTDFRGCMGEAFLN 2280
Cdd:cd00110 90 NGRSVTLSVD--GERVVESGSPGGSA------LLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKVN 151
|
|
| Laminin_G_1 |
pfam00054 |
Laminin G domain; |
2148-2285 |
7.34e-28 |
|
Laminin G domain;
Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 110.87 E-value: 7.34e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2148 VKTSEPDNLLFYMGSNSKADFMAVEMRQGKVSLLWDLGTGATRLEdPGMQINNNKWHKIHATRFGRSGTLAV--EEVNTS 2225
Cdd:pfam00054 1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVR-SGDKLNDGKWHSVELERNGRSGTLSVdgEARPTG 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1072240033 2226 qktstkpSSSPGTSSILHVDnsTLMFIGGIGG-GLQRSPALQTTDFRGCMGEAFLNGKSIG 2285
Cdd:pfam00054 80 -------ESPLGATTDLDVD--GPLYVGGLPSlGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
|
|
| Laminin_G_1 |
pfam00054 |
Laminin G domain; |
2939-3064 |
5.52e-27 |
|
Laminin G domain;
Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 108.17 E-value: 5.52e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2939 FRTTARNAVLL-GISSAKVDAIGLEIVNGRVLFHVNNGAGRITAIYKPEqansLCDGEWHQVNANKIKHKIVLKVDGN-T 3016
Cdd:pfam00054 1 FRTTEPSGLLLyNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDK----LNDGKWHSVELERNGRSGTLSVDGEaR 76
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1072240033 3017 ILTDSPHVQSTSADTSNPVYVGGYP-AGVKQNCLTSQTSFRGCIRNLKL 3064
Cdd:pfam00054 77 PTGESPLGATTDLDVDGPLYVGGLPsLGVKKRRLAISPSFDGCIRDVIV 125
|
|
| Laminin_G_2 |
pfam02210 |
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
2939-3064 |
2.81e-26 |
|
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.
Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 105.96 E-value: 2.81e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2939 FRTTARNAVLLGISSAKVDAIGLEIVNGRVLFHVNNGAGRITAIYKPEqanSLCDGEWHQVNANKIKHKIVLKVDGNTIL 3018
Cdd:pfam02210 1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGPESLLSSGK---NLNDGQWHSVRVERNGNTLTLSVDGQTVV 77
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1072240033 3019 TDSPHVQSTSADTSNPVYVGGYPAGVKQNCLTSQTSFRGCIRNLKL 3064
Cdd:pfam02210 78 SSLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRV 123
|
|
| LamG |
cd00110 |
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
2490-2655 |
7.09e-26 |
|
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 105.96 E-value: 7.09e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2490 SITVLNDGYVEM-QPVSLSPESELMVSFSTLNDTGIILagfgkaaekRSRRQAQLPFFALMLINGHIELHINplDGASTr 2568
Cdd:cd00110 1 GVSFSGSSYVRLpTLPAPRTRLSISFSFRTTSPNGLLL---------YAGSQNGGDFLALELEDGRLVLRYD--LGSGS- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2569 kTVIRSPTgTYSDGQEHSIILLRNKRFVSVQVDEGKPAEVKLNGPSVDLVAINafRFFIGGVPGKMGATMLRTSQSFYGC 2648
Cdd:cd00110 69 -LVLSSKT-PLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDG--PLYLGGLPEDLKSPGLPVSPGFVGC 144
|
....*..
gi 1072240033 2649 IQNLILN 2655
Cdd:cd00110 145 IRDLKVN 151
|
|
| LamG |
smart00282 |
Laminin G domain; |
2511-2655 |
8.30e-24 |
|
Laminin G domain;
Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 99.34 E-value: 8.30e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2511 ELMVSFSTLNDTGIILagfgkaaekRSRRQAQLPFFALMLINGHIELHINpldgASTRKTVIRSPTGTYSDGQEHSIILL 2590
Cdd:smart00282 1 SISFSFRTTSPNGLLL---------YAGSKGGGDYLALELRDGRLVLRYD----LGSGPARLTSDPTPLNDGQWHRVAVE 67
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1072240033 2591 RNKRFVSVQVDEGKPAEVKLNGPSVDLVAINafRFFIGGVPGKMGATMLRTSQSFYGCIQNLILN 2655
Cdd:smart00282 68 RNGRSVTLSVDGGNRVSGESPGGLTILNLDG--PLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVN 130
|
|
| Laminin_G_2 |
pfam02210 |
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
2762-2888 |
1.28e-23 |
|
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.
Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 98.65 E-value: 1.28e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2762 LRAYATSGLIYYMAHQNQmDYAALQLHDGKLHFLFDMGKGKTETI-HPVLINDGKWHTISTEYIKRKSTITVDGQEATST 2840
Cdd:pfam02210 1 FRTRQPNGLLLYAGGGGS-DFLALELVNGRLVLRYDLGSGPESLLsSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1072240033 2841 STPGESNSLDVEGKLYLGGLAPSYTAKNIGnVTHSIPACISNVSVNGK 2888
Cdd:pfam02210 80 LPPGESLLLNLNGPLYLGGLPPLLLLPALP-VRAGFVGCIRDVRVNGE 126
|
|
| Laminin_G_2 |
pfam02210 |
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
2148-2282 |
1.28e-22 |
|
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.
Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 95.56 E-value: 1.28e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2148 VKTSEPDNLLFYMGsNSKADFMAVEMRQGKVSLLWDLGTGATRLEDPGMQINNNKWHKIHATRFGRSGTLAVEEVNTSQk 2227
Cdd:pfam02210 1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS- 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1072240033 2228 tstkpSSSPGTSSILHVDNStlMFIGGIGGGLQRSPALQTTDFRGCMGEAFLNGK 2282
Cdd:pfam02210 79 -----SLPPGESLLLNLNGP--LYLGGLPPLLLLPALPVRAGFVGCIRDVRVNGE 126
|
|
| Laminin_G_1 |
pfam00054 |
Laminin G domain; |
2516-2660 |
5.72e-20 |
|
Laminin G domain;
Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 88.14 E-value: 5.72e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2516 FSTLNDTGIILAGfGKAAEKrsrrqaqlPFFALMLINGHIELHINPLDGAstrkTVIRSPTgTYSDGQEHSIILLRNKRF 2595
Cdd:pfam00054 1 FRTTEPSGLLLYN-GTQTER--------DFLALELRDGRLEVSYDLGSGA----AVVRSGD-KLNDGKWHSVELERNGRS 66
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1072240033 2596 VSVQVDEGKPAEV-KLNGPSVDLVAINAfrFFIGGVPG-KMGATMLRTSQSFYGCIQNLILNMEQLD 2660
Cdd:pfam00054 67 GTLSVDGEARPTGeSPLGATTDLDVDGP--LYVGGLPSlGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
|
|
| Laminin_G_2 |
pfam02210 |
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
2516-2655 |
1.24e-17 |
|
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.
Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 81.31 E-value: 1.24e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2516 FSTLNDTGIILAgfgkAAEKRSrrqaqlPFFALMLINGHIELHINpldgASTRKTVIRSPTGTYSDGQEHSIILLRNKRF 2595
Cdd:pfam02210 1 FRTRQPNGLLLY----AGGGGS------DFLALELVNGRLVLRYD----LGSGPESLLSSGKNLNDGQWHSVRVERNGNT 66
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1072240033 2596 VSVQVDEGKPAEVKLNGPSVDLvaiNAFR-FFIGGVPGKMGATMLRTSQSFYGCIQNLILN 2655
Cdd:pfam02210 67 LTLSVDGQTVVSSLPPGESLLL---NLNGpLYLGGLPPLLLLPALPVRAGFVGCIRDVRVN 124
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
900-946 |
3.05e-13 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 66.22 E-value: 3.05e-13
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1072240033 900 CECHPDSSISSMCHHDTGLCDCKPHVIGKKCDQCEPGFYGL--TSGLGC 946
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLpsDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
899-946 |
7.75e-13 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 65.07 E-value: 7.75e-13
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1072240033 899 ACECHPDSSISSMCHHDTGLCDCKPHVIGKKCDQCEPGFYGLTS-GLGC 946
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSqGGGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
900-946 |
3.49e-12 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 63.10 E-value: 3.49e-12
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1072240033 900 CECHPDSSISSMCHHDTGLCDCKPHVIGKKCDQCEPGFYGlTSGLGC 946
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYG-DGPPGC 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
739-787 |
3.57e-11 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 60.45 E-value: 3.57e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1072240033 739 PCDCNGHAT---DCD-IHGACYgCQHNTTGPHCDQCIPGFYGYPTAgtPQDCQ 787
Cdd:cd00055 1 PCDCNGHGSlsgQCDpGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQ--GGGCQ 50
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
740-786 |
1.77e-10 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 58.52 E-value: 1.77e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1072240033 740 CDCNGHAT---DCDIH-GACYgCQHNTTGPHCDQCIPGFYGYPTaGTPQDC 786
Cdd:pfam00053 1 CDCNPHGSlsdTCDPEtGQCL-CKPGVTGRHCDRCKPGYYGLPS-DPPQGC 49
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
397-454 |
1.84e-10 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 58.52 E-value: 1.84e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1072240033 397 CECDPFGSVSPVCVVDDnhstqgalpGQCPCKEGYTGTKCNQCAFGYKGYPHCVRCNC 454
Cdd:pfam00053 1 CDCNPHGSLSDTCDPET---------GQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
949-993 |
2.13e-10 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 58.09 E-value: 2.13e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1072240033 949 CNCSLSGSNSGVCD-DAGQCPCVSGVAGVKCDVCAQGFYGYEDGGC 993
Cdd:smart00180 1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
452-498 |
2.41e-10 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 58.13 E-value: 2.41e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1072240033 452 CNCSLIGSLND--DPCADQCICKEHVEGENCDRCKSGFYNLQEKNPEGC 498
Cdd:pfam00053 1 CDCNPHGSLSDtcDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1507-1541 |
3.24e-10 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 57.75 E-value: 3.24e-10
10 20 30
....*....|....*....|....*....|....*
gi 1072240033 1507 CDCNPSGSLHNHCDRITGQCVCKVGVTGRLCDTCE 1541
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCK 35
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
846-898 |
3.66e-10 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 57.36 E-value: 3.66e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1072240033 846 PCDCNGNIDpfEDGHCDSVTGECLkCIGNTAGRYCERCADGFHGDAIFVKNCT 898
Cdd:cd00055 1 PCDCNGHGS--LSGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1507-1554 |
4.49e-10 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 57.36 E-value: 4.49e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1072240033 1507 CDCNPSGSLHNHCDRITGQCVCKVGVTGRLCDTCEVRHTLLEQQCISC 1554
Cdd:cd00055 2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1507-1541 |
8.07e-10 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 56.55 E-value: 8.07e-10
10 20 30
....*....|....*....|....*....|....*
gi 1072240033 1507 CDCNPSGSLHNHCDRITGQCVCKVGVTGRLCDTCE 1541
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCA 35
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1042-1090 |
8.69e-10 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 56.59 E-value: 8.69e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1072240033 1042 CNCSTDGSSSLQCDLTTGQCLCRKEFAGQTCNTCLFGYRKYPSCISCDC 1090
Cdd:pfam00053 1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
396-447 |
1.37e-09 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 55.82 E-value: 1.37e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1072240033 396 PCECDPFGSVSPVCVVDDnhstqgalpGQCPCKEGYTGTKCNQCAFGYKGYP 447
Cdd:cd00055 1 PCDCNGHGSLSGQCDPGT---------GQCECKPNTTGRRCDRCAPGYYGLP 43
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
847-892 |
2.10e-09 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 55.44 E-value: 2.10e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1072240033 847 CDCNGNIDPfeDGHCDSVTGECLkCIGNTAGRYCERCADGFHGDAI 892
Cdd:pfam00053 1 CDCNPHGSL--SDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPS 43
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
397-447 |
5.44e-09 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 54.24 E-value: 5.44e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1072240033 397 CECDPFGSVSPVCVVDDnhstqgalpGQCPCKEGYTGTKCNQCAFGYKGYP 447
Cdd:smart00180 1 CDCDPGGSASGTCDPDT---------GQCECKPNVTGRRCDRCAPGYYGDG 42
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
451-499 |
6.06e-09 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 53.90 E-value: 6.06e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1072240033 451 RCNCSLIGSLND--DPCADQCICKEHVEGENCDRCKSGFYNLQEkNPEGCT 499
Cdd:cd00055 1 PCDCNGHGSLSGqcDPGTGQCECKPNTTGRRCDRCAPGYYGLPS-QGGGCQ 50
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
949-996 |
7.06e-09 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 53.90 E-value: 7.06e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1072240033 949 CNCSLSGSNSGVCD-DAGQCPCVSGVAGVKCDVCAQGFYGYEDGGCTAC 996
Cdd:pfam00053 1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
452-498 |
7.82e-09 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 53.47 E-value: 7.82e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1072240033 452 CNCSLIGSLND--DPCADQCICKEHVEGENCDRCKSGFYNlqeKNPEGC 498
Cdd:smart00180 1 CDCDPGGSASGtcDPDTGQCECKPNVTGRRCDRCAPGYYG---DGPPGC 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
948-992 |
2.34e-08 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 52.36 E-value: 2.34e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1072240033 948 PCNCSLSGSNSGVCD-DAGQCPCVSGVAGVKCDVCAQGFYGYEDGG 992
Cdd:cd00055 1 PCDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1042-1084 |
2.41e-08 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 52.36 E-value: 2.41e-08
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1072240033 1042 CNCSTDGSSSLQCDLTTGQCLCRKEFAGQTCNTCLFGYRKYPS 1084
Cdd:cd00055 2 CDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS 44
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1042-1079 |
4.93e-08 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 51.54 E-value: 4.93e-08
10 20 30
....*....|....*....|....*....|....*...
gi 1072240033 1042 CNCSTDGSSSLQCDLTTGQCLCRKEFAGQTCNTCLFGY 1079
Cdd:smart00180 1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGY 38
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1401-1447 |
6.71e-08 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 51.20 E-value: 6.71e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1401 CQCSNH---SEICDPDTGECLgCTDNTAGHHCHVCASGYYGKVAGSITDC 1447
Cdd:pfam00053 1 CDCNPHgslSDTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
740-781 |
7.58e-08 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 50.77 E-value: 7.58e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1072240033 740 CDCN--GHATD-CD-IHGACYgCQHNTTGPHCDQCIPGFYGYPTAG 781
Cdd:smart00180 1 CDCDpgGSASGtCDpDTGQCE-CKPNVTGRRCDRCAPGYYGDGPPG 45
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
996-1039 |
1.07e-07 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 50.43 E-value: 1.07e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1072240033 996 CDCEH---TQNNCNPQTGECICPPHTHGSKCEFCKANYWG--HDPELGC 1039
Cdd:pfam00053 1 CDCNPhgsLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGlpSDPPQGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
996-1039 |
1.90e-07 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 49.62 E-value: 1.90e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1072240033 996 CDCE---HTQNNCNPQTGECICPPHTHGSKCEFCKANYWGHDPElGC 1039
Cdd:smart00180 1 CDCDpggSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPP-GC 46
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1088-1145 |
3.28e-07 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 49.27 E-value: 3.28e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1072240033 1088 CDCDVKGTQSAWCDdeqkmcscgEETGNCACKDNVIGSYCNECKGGTFALHGENPLGC 1145
Cdd:pfam00053 1 CDCNPHGSLSDTCD---------PETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
995-1039 |
3.71e-07 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 48.89 E-value: 3.71e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1072240033 995 ACDCEHT---QNNCNPQTGECICPPHTHGSKCEFCKANYWGHDPE-LGC 1039
Cdd:cd00055 1 PCDCNGHgslSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQgGGC 49
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
789-844 |
4.72e-07 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 48.89 E-value: 4.72e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1072240033 789 CACPLNAPSnnfSPTCYLSGeedVICdQCAPGYTGPRCEKCANGYYGNPSVLGGSC 844
Cdd:pfam00053 1 CDCNPHGSL---SDTCDPET---GQC-LCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1400-1438 |
6.82e-07 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 48.12 E-value: 6.82e-07
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1072240033 1400 PCQCSNH---SEICDPDTGECLgCTDNTAGHHCHVCASGYYG 1438
Cdd:cd00055 1 PCDCNGHgslSGQCDPGTGQCE-CKPNTTGRRCDRCAPGYYG 41
|
|
| Laminin_EGF |
pfam00053 |
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six. |
1450-1504 |
1.40e-06 |
|
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
Pssm-ID: 395007 Cd Length: 49 Bit Score: 47.35 E-value: 1.40e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1072240033 1450 CACPkgNSKSFSPTCVLEGiddFRCDaCLPGYEGKYCERCSLGYFGNPSDPDGSC 1504
Cdd:pfam00053 1 CDCN--PHGSLSDTCDPET---GQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
847-890 |
1.91e-06 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 46.92 E-value: 1.91e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1072240033 847 CDCN--GNIDPfedgHCDSVTGECLkCIGNTAGRYCERCADGFHGD 890
Cdd:smart00180 1 CDCDpgGSASG----TCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD 41
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
270-317 |
2.54e-06 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 46.58 E-value: 2.54e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1072240033 270 CICYGHA---RSCpwDEVTqkLQCQCERNTCGESCNECCPGYHQNPWRPGT 317
Cdd:cd00055 2 CDCNGHGslsGQC--DPGT--GQCECKPNTTGRRCDRCAPGYYGLPSQGGG 48
|
|
| 235kDa-fam |
TIGR01612 |
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ... |
1575-2183 |
3.61e-06 |
|
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.
Pssm-ID: 130673 [Multi-domain] Cd Length: 2757 Bit Score: 53.13 E-value: 3.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1575 SINFTGIVTVPHGFMTHLENMTMHVKDSVFTNSNKTQNLDQTVKQ-LNAVSADTVLLHNRL-AQVKKHGFSVH------- 1645
Cdd:TIGR01612 816 SKEYIKTISIKEDEIFKIINEMKFMKDDFLNKVDKFINFENNCKEkIDSEHEQFAELTNKIkAEISDDKLNDYekkfnds 895
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1646 NSTINTLNKSQEL----MGFIDKMQTTIKVLIEVAES----------LNETLGS--DALLPVN---------YQEGVLSK 1700
Cdd:TIGR01612 896 KSLINEINKSIEEeyqnINTLKKVDEYIKICENTKESiekfhnkqniLKEILNKniDTIKESNlieksykdkFDNTLIDK 975
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1701 LGELStRSFSDHNQNAVE-NVKALDVLLSRVQKEFGKPH--------DDLAKVKKSLENSLDQHTSKLLAAEDFIYESAS 1771
Cdd:TIGR01612 976 INELD-KAFKDASLNDYEaKNNELIKYFNDLKANLGKNKenmlyhqfDEKEKATNDIEQKIEDANKNIPNIEIAIHTSIY 1054
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1772 NLNTT------NNLLVVIQNNLEDFSVKKLNFQENK------NRSVMLIEEGLGLVDEAVLLAEDTINATSVLEMHQEEL 1839
Cdd:TIGR01612 1055 NIIDEiekeigKNIELLNKEILEEAEINITNFNEIKeklkhyNFDDFGKEENIKYADEINKIKDDIKNLDQKIDHHIKAL 1134
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1840 IMWNTKLRHHVDELVMQMSK-RDALDLAYNSEDhaaallrlsdslnssLSDVRNTSFNATNAIQAHSNI-----KRMVEQ 1913
Cdd:TIGR01612 1135 EEIKKKSENYIDEIKAQINDlEDVADKAISNDD---------------PEEIEKKIENIVTKIDKKKNIydeikKLLNEI 1199
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1914 AEVLAEQSNYtisETVRLVSGPNGSLVGTskdslMFSSQlVNESKNLSRNT----EGLVSHLNGLKTKVDEIQKRTRVfT 1989
Cdd:TIGR01612 1200 AEIEKDKTSL---EEVKGINLSYGKNLGK-----LFLEK-IDEEKKKSEHMikamEAYIEDLDEIKEKSPEIENEMGI-E 1269
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1990 GQINEQLRSLrslpNDTSSKLQEAKDLALSANTtaagTLGHIMNFSQKLSNATSTLSRVNDTLQRTNVLLVDSSKAAVSA 2069
Cdd:TIGR01612 1270 MDIKAEMETF----NISHDDDKDHHIISKKHDE----NISDIREKSLKIIEDFSEESDINDIKKELQKNLLDAQKHNSDI 1341
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2070 ESRIKEVETQANIL-LDRLKPM----KLLEENLSRNLSEIKELINQARKQAASIKVAVSAdRDCVRSYHPEIRSTNFNTL 2144
Cdd:TIGR01612 1342 NLYLNEIANIYNILkLNKIKKIidevKEYTKEIEENNKNIKDELDKSEKLIKKIKDDINL-EECKSKIESTLDDKDIDEC 1420
|
650 660 670
....*....|....*....|....*....|....*....
gi 1072240033 2145 ILNVKTSEpdNLLFYMGSNSKADFMAVEMRQGKVSLLWD 2183
Cdd:TIGR01612 1421 IKKIKELK--NHILSEESNIDTYFKNADENNENVLLLFK 1457
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
804-842 |
1.39e-05 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 44.65 E-value: 1.39e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1072240033 804 CYLSGEEDVICDQ------CAPGYTGPRCEKCANGYYGNPSVLGG 842
Cdd:cd00055 4 CNGHGSLSGQCDPgtgqceCKPNTTGRRCDRCAPGYYGLPSQGGG 48
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
789-837 |
1.53e-05 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 44.22 E-value: 1.53e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1072240033 789 CACPlnaPSNNFSPTCYLsgeEDVICdQCAPGYTGPRCEKCANGYYGNP 837
Cdd:smart00180 1 CDCD---PGGSASGTCDP---DTGQC-ECKPNVTGRRCDRCAPGYYGDG 42
|
|
| VSP |
pfam03302 |
Giardia variant-specific surface protein; |
703-1021 |
2.10e-05 |
|
Giardia variant-specific surface protein;
Pssm-ID: 146106 [Multi-domain] Cd Length: 397 Bit Score: 49.97 E-value: 2.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 703 QVENCECPPGYAGTSCESCIPGYYRVGGTLFGGICQPCDCNGHATDCDIHGACYGC-----QHNTTGPHCDQCIPGFYGY 777
Cdd:pfam03302 24 KTENCKACSNDKREVCEECNSNNYLTPTSQCIDDCAKIGNYYYTTNANNKKICKECtvancKTCEDQGQCQACNDGFYKS 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 778 PTAGTPQDCQLCACplNAPSNNFSPTC-------YLSGEEDVIC-DQCAPGYTGPRCEKCAngyygnpSVLGGSCVPCDC 849
Cdd:pfam03302 104 GDACSPCHESCKTC--SGGTASDCTECltgkalrYGNDGTKGTCgEGCTTGTGAGACKTCG-------LTIDGTSYCSEC 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 850 NGNIDPFEDGHCDSVTGECLKCI--GNTAGRYCERCADGFhgdaiFVKN--CTACECHPDSSIssmCHHDTGLCDCKPHV 925
Cdd:pfam03302 175 ATETEYPQNGVCTSTAARATATCkaSSVANGMCSSCANGY-----FRMNggCYETTKFPGKSV---CEEANSGGTCQKEA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 926 IGKKCDQ-----CEPGFYGLTSGLGCLPCncslsgsNSGVCDDAGQCP-CVSGV-----AGVKCDVCAQGFYGyEDGGCT 994
Cdd:pfam03302 247 PGYKLNNgdlvtCSPGCKTCTSNTVCTTC-------MDGYVKTSDSCTkCDSSCetctgATTTCKTCATGYYK-SGTGCV 318
|
330 340
....*....|....*....|....*....
gi 1072240033 995 ACDCEHTQNNCNPQTG--ECICPPHTHGS 1021
Cdd:pfam03302 319 SCTSSESDNGITGVKGclNCAPPSNNKGS 347
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1401-1443 |
2.59e-05 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 43.84 E-value: 2.59e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1072240033 1401 CQCS---NHSEICDPDTGECLgCTDNTAGHHCHVCASGYYGKVAGS 1443
Cdd:smart00180 1 CDCDpggSASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGDGPPG 45
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1088-1145 |
3.66e-05 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 43.45 E-value: 3.66e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1072240033 1088 CDCDVKGTQSAWCDdeqkmcscgEETGNCACKDNVIGSYCNECKGGTFalhGENPLGC 1145
Cdd:smart00180 1 CDCDPGGSASGTCD---------PDTGQCECKPNVTGRRCDRCAPGYY---GDGPPGC 46
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
1602-2110 |
3.90e-05 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 49.63 E-value: 3.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1602 SVFTNS-----------NKTQN-LDQTVKQLNAVSADtvlLHNRLAQVKkhgfsvhnSTINTLNKSQELmgfIDKMQTTI 1669
Cdd:TIGR04523 12 SVFTATgfsyvgykniaNKQDTeEKQLEKKLKTIKNE---LKNKEKELK--------NLDKNLNKDEEK---INNSNNKI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1670 KVLIEVAESLNETLgsdallpvNYQEGVLSKLGELSTRSFSDHNqNAVENVKALDVLLSRVQKEFGKPHDDLAKVK---K 1746
Cdd:TIGR04523 78 KILEQQIKDLNDKL--------KKNKDKINKLNSDLSKINSEIK-NDKEQKNKLEVELNKLEKQKKENKKNIDKFLteiK 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1747 SLENSLDQHTSKLLAAEDFIYESASNLNTTNNLLVVIQNNLEDfsVKKLNFQENKNRSVM--LIEEGLGLVDEAVLLAED 1824
Cdd:TIGR04523 149 KKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDK--IKNKLLKLELLLSNLkkKIQKNKSLESQISELKKQ 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1825 TINATSVLEMHQEELIMWNTKLRhhvdelvmqmskrdaldlaynsedhaaallrlsdslnsslsdvrNTSFNATNAIQAH 1904
Cdd:TIGR04523 227 NNQLKDNIEKKQQEINEKTTEIS--------------------------------------------NTQTQLNQLKDEQ 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1905 SNIKRMVEQAEVLAEQSNYTISETVRLVSGPNGSLV--------GTSKDslmFSSQLVNESKNLS------RNTEGLVSH 1970
Cdd:TIGR04523 263 NKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISdlnnqkeqDWNKE---LKSELKNQEKKLEeiqnqiSQNNKIISQ 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1971 LNG--------LKTKVDEIQKRTRvftgQINEQLRSLRSLPNDTSSKLQEAKDLALSANttaagtlghimNFSQKLSNAt 2042
Cdd:TIGR04523 340 LNEqisqlkkeLTNSESENSEKQR----ELEEKQNEIEKLKKENQSYKQEIKNLESQIN-----------DLESKIQNQ- 403
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1072240033 2043 stlsrvndtlQRTNVLLvdsskaavsaESRIKEVETQANILLDRLKpmKLLEENLSRNlSEIKELINQ 2110
Cdd:TIGR04523 404 ----------EKLNQQK----------DEQIKKLQQEKELLEKEIE--RLKETIIKNN-SEIKDLTNQ 448
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1087-1145 |
2.75e-04 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 40.80 E-value: 2.75e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1072240033 1087 SCDCDVKGTQSAWCDDEqkmcscgeeTGNCACKDNVIGSYCNECKGGTFALhGENPLGC 1145
Cdd:cd00055 1 PCDCNGHGSLSGQCDPG---------TGQCECKPNTTGRRCDRCAPGYYGL-PSQGGGC 49
|
|
| EGF_Lam |
cd00055 |
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ... |
1450-1505 |
5.01e-04 |
|
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
Pssm-ID: 238012 Cd Length: 50 Bit Score: 40.03 E-value: 5.01e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1072240033 1450 CACPKGNSKSfsPTCVLEgidDFRCDaCLPGYEGKYCERCSLGYFGNPSDPDGsCQ 1505
Cdd:cd00055 2 CDCNGHGSLS--GQCDPG---TGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGG-CQ 50
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
1450-1497 |
7.94e-04 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 39.60 E-value: 7.94e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1072240033 1450 CACPKGNSksFSPTCVLegiDDFRCDaCLPGYEGKYCERCSLGYFGNP 1497
Cdd:smart00180 1 CDCDPGGS--ASGTCDP---DTGQCE-CKPNVTGRRCDRCAPGYYGDG 42
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
1953-2119 |
8.56e-04 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 45.05 E-value: 8.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1953 LVNESKNLSRNTEGLVSHLNGLKTKVDEIQKRTRVFTGQINEqlrsLRSLPNDTSSKLQEAKDLALSANTTAAGTLGHIM 2032
Cdd:TIGR02168 230 LVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEE----LRLEVSELEEEIEELQKELYALANEISRLEQQKQ 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2033 NFSQKLSNATSTLSRVNDTLQRTNVLLVDSSKAAVSAESRIKEVETQANILLDRLKPMKLLEENLSRNLSEIKELINQAR 2112
Cdd:TIGR02168 306 ILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLR 385
|
....*..
gi 1072240033 2113 KQAASIK 2119
Cdd:TIGR02168 386 SKVAQLE 392
|
|
| TNFRSF4 |
cd13406 |
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40; ... |
814-963 |
1.04e-03 |
|
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40; TNFRSF4 (also known as OX40, ACT35, CD134, IMD16, TXGP1L) activates NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. It also promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. It is primarily expressed on activated CD4+ and CD8+ T cells, where it is transiently expressed and upregulated on the most recently antigen-activated T cells within inflammatory lesions. This makes it an attractive target to modulate immune responses, i.e. TNFRSF4 (OX40) blocking agents to inhibit adverse inflammation or agonists to enhance immune responses. An artificially created biologic fusion protein, OX40-immunoglobulin (OX40-Ig), prevents OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Some single nucleotide polymorphisms (SNPs) of its natural ligand OX40 ligand (OX40L, CD252), which is also found on activated T cells, have been associated with systemic lupus erythematosus.
Pssm-ID: 276911 [Multi-domain] Cd Length: 142 Bit Score: 42.00 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 814 CDQCAPGY---------TGPRCEKCANGYYgNPSVLGGSCVPCDcngnidpfedgHCDSVTGECLKcigntagRYCERCA 884
Cdd:cd13406 15 CHECPPGEgmesrctgtQDTVCSPCEPGFY-NEAVNYEPCKPCT-----------QCNQRSGSEEK-------QKCTKTS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 885 DgfhgdaifvkncTACECHPdssiSSMCHHDtglcdckpHVIGKKCDQCEPGFYGLTSGLGCLP-CNCSLSG-------- 955
Cdd:cd13406 76 D------------TVCRCRP----GTQPLDS--------YKPGVDCVPCPPGHFSRGDNQACKPwTNCSLAGkrtlrpgs 131
|
....*....
gi 1072240033 956 -SNSGVCDD 963
Cdd:cd13406 132 sTSDAVCED 140
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
1972-2119 |
1.27e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 44.12 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1972 NGLKTKVDEIQKRTRVFT-GQINEQLRSLRSLPNDTSSKLQEAKdlalsanttaagtlghimnfsQKLSNATSTLSRVND 2050
Cdd:COG4372 22 TGILIAALSEQLRKALFElDKLQEELEQLREELEQAREELEQLE---------------------EELEQARSELEQLEE 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1072240033 2051 TLQRTNVLLVDSSKAAVSAESRIKEVETQANILLDRL----KPMKLLEENLSRNLSEIKELINQARKQAASIK 2119
Cdd:COG4372 81 ELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELeelqKERQDLEQQRKQLEAQIAELQSEIAEREEELK 153
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
1953-2124 |
3.23e-03 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 43.13 E-value: 3.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 1953 LVNESKNLSRNTEGLVSHLNGLKTKVDEIQKRTRVFTGQ---INEQLRSLRSLPNDTSSKLqEAKDLALSANTTAAGTLG 2029
Cdd:TIGR02169 383 TRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEEladLNAAIAGIEAKINELEEEK-EDKALEIKKQEWKLEQLA 461
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072240033 2030 HIM-NFSQKLSNATSTLSRVNDTLQrtnvllvdsskaavSAESRIKEVETQANILLDRLKPMKLLEENLSRNLS----EI 2104
Cdd:TIGR02169 462 ADLsKYEQELYDLKEEYDRVEKELS--------------KLQRELAEAEAQARASEERVRGGRAVEEVLKASIQgvhgTV 527
|
170 180
....*....|....*....|
gi 1072240033 2105 KELINQARKQAASIKVAVSA 2124
Cdd:TIGR02169 528 AQLGSVGERYATAIEVAAGN 547
|
|
| EGF_Lam |
smart00180 |
Laminin-type epidermal growth factor-like domai; |
289-313 |
4.77e-03 |
|
Laminin-type epidermal growth factor-like domai;
Pssm-ID: 214543 Cd Length: 46 Bit Score: 37.29 E-value: 4.77e-03
|
| |
