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Conserved domains on  [gi|1070099198|ref|YP_009281924|]
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btb kelch-domain containing protein [Volepox virus]

Protein Classification

kelch repeat domain-containing protein( domain architecture ID 1000219)

kelch repeat domain-containing protein such as human kelch-like protein 1 that may play a role in organizing the actin cytoskeleton of the brain cells

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03098 super family cl33709
kelch-like protein; Provisional
 14-526 1.55e-132

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 396.83  E-value: 1.55e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  14 FRKKRRFCD--VIIVVNDERIDAHRIILSGASEYFSILFSSNFIDsdnYEVNLSHlDYQCINELINYIYGVPLTLTNDNV 91
Cdd:PHA03098    3 SFELQKFCDesIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE---NEINLNI-DYDSFNEVIKYIYTGKINITSNNV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  92 KYILSTADFLQISSAIKECEKFILGNLCSRNCIDVYMYAIEYNNKKIETACFDIILQNILLLINNENFKHLTEESMIKIL 171
Cdd:PHA03098   79 KDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKIL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 172 RDDRLNIKNEDFSPLILIKWLECTQNPCSV---ELLRCLRITLLSPQIIKAL-------------YNHHLIKSQDECLTF 235
Cdd:PHA03098  159 SDDKLNVSSEDVVLEIIIKWLTSKKNNKYKdicLILKVLRITFLSEEGIKKLkrwklrikkkkivFNKRCIKIIYSKKYN 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 236 LNNISFLEETFPRYNSIALISIgigrsHDNISINCYNNKKNTWDMISARRFRCNFAVAVLDNIVYMMGGHGDSLYRMSQV 315
Cdd:PHA03098  239 LNKILPRSSTFGSIIYIHITMS-----IFTYNYITNYSPLSEINTIIDIHYVYCFGSVVLNNVIYFIGGMNKNNLSVNSV 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 316 IAYDIRNNSWiYDIPSLKYPRSNCRGLTDDEYIYCIGGIRGHhlSFVSDIDRWKPSKPYWQSYAKMREKKCDMGVVMLNG 395
Cdd:PHA03098  314 VSYDTKTKSW-NKVPELIYPRKNPGVTVFNNRIYVIGGIYNS--ISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNN 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 396 LIYIIGGIIKDNTCTNSVESLS--EDGWTIHQPLPIKMSNMATTVHAGKIYISGGYDNTNNIinGQSNLVFSYDPIYDEW 473
Cdd:PHA03098  391 LIYVIGGISKNDELLKTVECFSlnTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNI--KVYNIVESYNPVTNKW 468

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1070099198 474 TKLSSLNIPRINPALWSSNNKIYVCGGISDDIRTGMSESYDEEKDCWILDNYH 526
Cdd:PHA03098  469 TELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCKF 521
 
Name Accession Description Interval E-value
PHA03098 PHA03098
kelch-like protein; Provisional
 14-526 1.55e-132

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 396.83  E-value: 1.55e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  14 FRKKRRFCD--VIIVVNDERIDAHRIILSGASEYFSILFSSNFIDsdnYEVNLSHlDYQCINELINYIYGVPLTLTNDNV 91
Cdd:PHA03098    3 SFELQKFCDesIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE---NEINLNI-DYDSFNEVIKYIYTGKINITSNNV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  92 KYILSTADFLQISSAIKECEKFILGNLCSRNCIDVYMYAIEYNNKKIETACFDIILQNILLLINNENFKHLTEESMIKIL 171
Cdd:PHA03098   79 KDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKIL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 172 RDDRLNIKNEDFSPLILIKWLECTQNPCSV---ELLRCLRITLLSPQIIKAL-------------YNHHLIKSQDECLTF 235
Cdd:PHA03098  159 SDDKLNVSSEDVVLEIIIKWLTSKKNNKYKdicLILKVLRITFLSEEGIKKLkrwklrikkkkivFNKRCIKIIYSKKYN 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 236 LNNISFLEETFPRYNSIALISIgigrsHDNISINCYNNKKNTWDMISARRFRCNFAVAVLDNIVYMMGGHGDSLYRMSQV 315
Cdd:PHA03098  239 LNKILPRSSTFGSIIYIHITMS-----IFTYNYITNYSPLSEINTIIDIHYVYCFGSVVLNNVIYFIGGMNKNNLSVNSV 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 316 IAYDIRNNSWiYDIPSLKYPRSNCRGLTDDEYIYCIGGIRGHhlSFVSDIDRWKPSKPYWQSYAKMREKKCDMGVVMLNG 395
Cdd:PHA03098  314 VSYDTKTKSW-NKVPELIYPRKNPGVTVFNNRIYVIGGIYNS--ISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNN 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 396 LIYIIGGIIKDNTCTNSVESLS--EDGWTIHQPLPIKMSNMATTVHAGKIYISGGYDNTNNIinGQSNLVFSYDPIYDEW 473
Cdd:PHA03098  391 LIYVIGGISKNDELLKTVECFSlnTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNI--KVYNIVESYNPVTNKW 468

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1070099198 474 TKLSSLNIPRINPALWSSNNKIYVCGGISDDIRTGMSESYDEEKDCWILDNYH 526
Cdd:PHA03098  469 TELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCKF 521
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 12-118 1.21e-26

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 104.26  E-value: 1.21e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  12 NEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVPLtLTNDNV 91
Cdd:pfam00651   2 NELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEENV 80

                          90       100
                  ....*....|....*....|....*..
gi 1070099198  92 KYILSTADFLQISSAIKECEKFILGNL 118
Cdd:pfam00651  81 DDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-126 1.08e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 101.95  E-value: 1.08e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGV 82
Cdd:cd18306     1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCIDV 126
Cdd:cd18306    81 RLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
246-500 1.31e-22

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 97.92  E-value: 1.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 246 FPRYNSIALIS-----IGIGRSHDNIS--INCYNNKKNTW----DMISARRFrcNFAVAVLDNIVYMMGG---HGDSLYR 311
Cdd:COG3055    11 TPRSEAAAALLdgkvyVAGGLSGGSASnsFEVYDPATNTWselaPLPGPPRH--HAAAVAQDGKLYVFGGftgANPSSTP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 312 MSQVIAYDIRNNSWiYDIPSLKYPRSNCRGLTDDEYIYCIGGIRGHHlsFVSDIDRWKPSKPYWQSYAKMREKKCDMGVV 391
Cdd:COG3055    89 LNDVYVYDPATNTW-TKLAPMPTPRGGATALLLDGKIYVVGGWDDGG--NVAWVEVYDPATGTWTQLAPLPTPRDHLAAA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 392 MLNgliyiiggiikDNT---CTNSVESLSEDGWTIHQPLPIKMSNMATTVHAGKIYISGGYDNTnniingqSNLVFSYDP 468
Cdd:COG3055   166 VLP-----------DGKilvIGGRNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGF-------SDEVEAYDP 227

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1070099198 469 IYDEWTKLSSLNIPRINPALWSSNNKIYVCGG 500
Cdd:COG3055   228 ATNTWTALGELPTPRHGHAAVLTDGKVYVIGG 259
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 22-118 5.84e-22

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 90.44  E-value: 5.84e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   22 DVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVPLTLTNDNVKYILSTADFL 101
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 1070099198  102 QISSAIKECEKFILGNL 118
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
 
Name Accession Description Interval E-value
PHA03098 PHA03098
kelch-like protein; Provisional
 14-526 1.55e-132

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 396.83  E-value: 1.55e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  14 FRKKRRFCD--VIIVVNDERIDAHRIILSGASEYFSILFSSNFIDsdnYEVNLSHlDYQCINELINYIYGVPLTLTNDNV 91
Cdd:PHA03098    3 SFELQKFCDesIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE---NEINLNI-DYDSFNEVIKYIYTGKINITSNNV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  92 KYILSTADFLQISSAIKECEKFILGNLCSRNCIDVYMYAIEYNNKKIETACFDIILQNILLLINNENFKHLTEESMIKIL 171
Cdd:PHA03098   79 KDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKIL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 172 RDDRLNIKNEDFSPLILIKWLECTQNPCSV---ELLRCLRITLLSPQIIKAL-------------YNHHLIKSQDECLTF 235
Cdd:PHA03098  159 SDDKLNVSSEDVVLEIIIKWLTSKKNNKYKdicLILKVLRITFLSEEGIKKLkrwklrikkkkivFNKRCIKIIYSKKYN 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 236 LNNISFLEETFPRYNSIALISIgigrsHDNISINCYNNKKNTWDMISARRFRCNFAVAVLDNIVYMMGGHGDSLYRMSQV 315
Cdd:PHA03098  239 LNKILPRSSTFGSIIYIHITMS-----IFTYNYITNYSPLSEINTIIDIHYVYCFGSVVLNNVIYFIGGMNKNNLSVNSV 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 316 IAYDIRNNSWiYDIPSLKYPRSNCRGLTDDEYIYCIGGIRGHhlSFVSDIDRWKPSKPYWQSYAKMREKKCDMGVVMLNG 395
Cdd:PHA03098  314 VSYDTKTKSW-NKVPELIYPRKNPGVTVFNNRIYVIGGIYNS--ISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNN 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 396 LIYIIGGIIKDNTCTNSVESLS--EDGWTIHQPLPIKMSNMATTVHAGKIYISGGYDNTNNIinGQSNLVFSYDPIYDEW 473
Cdd:PHA03098  391 LIYVIGGISKNDELLKTVECFSlnTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNI--KVYNIVESYNPVTNKW 468

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1070099198 474 TKLSSLNIPRINPALWSSNNKIYVCGGISDDIRTGMSESYDEEKDCWILDNYH 526
Cdd:PHA03098  469 TELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCKF 521
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 12-118 1.21e-26

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 104.26  E-value: 1.21e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  12 NEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVPLtLTNDNV 91
Cdd:pfam00651   2 NELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEENV 80

                          90       100
                  ....*....|....*....|....*..
gi 1070099198  92 KYILSTADFLQISSAIKECEKFILGNL 118
Cdd:pfam00651  81 DDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-126 1.08e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 101.95  E-value: 1.08e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGV 82
Cdd:cd18306     1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCIDV 126
Cdd:cd18306    81 RLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-124 3.46e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 99.75  E-value: 3.46e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  21 CDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVPLTLTNDNVKYILSTADF 100
Cdd:cd18234     2 CDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATACL 81

                          90       100
                  ....*....|....*....|....
gi 1070099198 101 LQISSAIKECEKFILGNLCSRNCI 124
Cdd:cd18234    82 LQLSEVVEACCGFLMKQLHPSNCL 105
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-124 7.41e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 96.79  E-value: 7.41e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   1 MNHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIY 80
Cdd:cd18237     2 AKLLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1070099198  81 GVPLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCI 124
Cdd:cd18237    82 TARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
246-500 1.31e-22

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 97.92  E-value: 1.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 246 FPRYNSIALIS-----IGIGRSHDNIS--INCYNNKKNTW----DMISARRFrcNFAVAVLDNIVYMMGG---HGDSLYR 311
Cdd:COG3055    11 TPRSEAAAALLdgkvyVAGGLSGGSASnsFEVYDPATNTWselaPLPGPPRH--HAAAVAQDGKLYVFGGftgANPSSTP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 312 MSQVIAYDIRNNSWiYDIPSLKYPRSNCRGLTDDEYIYCIGGIRGHHlsFVSDIDRWKPSKPYWQSYAKMREKKCDMGVV 391
Cdd:COG3055    89 LNDVYVYDPATNTW-TKLAPMPTPRGGATALLLDGKIYVVGGWDDGG--NVAWVEVYDPATGTWTQLAPLPTPRDHLAAA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 392 MLNgliyiiggiikDNT---CTNSVESLSEDGWTIHQPLPIKMSNMATTVHAGKIYISGGYDNTnniingqSNLVFSYDP 468
Cdd:COG3055   166 VLP-----------DGKilvIGGRNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGF-------SDEVEAYDP 227

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1070099198 469 IYDEWTKLSSLNIPRINPALWSSNNKIYVCGG 500
Cdd:COG3055   228 ATNTWTALGELPTPRHGHAAVLTDGKVYVIGG 259
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-118 1.42e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 92.99  E-value: 1.42e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGV 82
Cdd:cd18257     1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTG 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEKFILGNL 118
Cdd:cd18257    81 TVFISQATVESLLPAANLLQIKLVLKECCDFLESQL 116
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 4-123 3.22e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 92.01  E-value: 3.22e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   4 SDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVP 83
Cdd:cd18240     1 SAMACNVFNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1070099198  84 LTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNC 123
Cdd:cd18240    81 VPITAENVEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-124 4.15e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 92.08  E-value: 4.15e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYG 81
Cdd:cd18256     2 KHASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYT 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1070099198  82 VPLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCI 124
Cdd:cd18256    82 GVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCI 124
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 22-118 5.84e-22

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 90.44  E-value: 5.84e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   22 DVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVPLTLTNDNVKYILSTADFL 101
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 1070099198  102 QISSAIKECEKFILGNL 118
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-123 7.46e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 90.92  E-value: 7.46e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGV 82
Cdd:cd18255     1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNC 123
Cdd:cd18255    81 ELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-118 4.90e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 88.62  E-value: 4.90e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGV 82
Cdd:cd18339     4 HMKKAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTA 83

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEKFILGNL 118
Cdd:cd18339    84 EIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQL 119
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-126 1.08e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 87.79  E-value: 1.08e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYG 81
Cdd:cd18336     1 NHAEQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1070099198  82 VPLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCIDV 126
Cdd:cd18336    81 GVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-101 2.05e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 85.68  E-value: 2.05e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  20 FCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVPLTLTNDNVKYILSTAD 99
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80


                  ..
gi 1070099198 100 FL 101
Cdd:cd18186    81 KL 82
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-114 2.27e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 86.71  E-value: 2.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGV 82
Cdd:cd18235     4 HTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYTA 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEKFI 114
Cdd:cd18235    84 EIQVTEENVQVLLPAANLLQLTDVRDACCDFL 115
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-115 3.85e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 85.80  E-value: 3.85e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   9 SIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVPLTLTN 88
Cdd:cd18247     8 PVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSGRIAIDT 87

                          90       100
                  ....*....|....*....|....*..
gi 1070099198  89 DNVKYILSTADFLQISSAIKECEKFIL 115
Cdd:cd18247    88 SNVQSLLVGASFLQLQSVKDACCEFLK 114
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-126 5.72e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 85.88  E-value: 5.72e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   1 MNHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIY 80
Cdd:cd18337     4 LNHAEQTFKKMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQYAY 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1070099198  81 GVPLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCIDV 126
Cdd:cd18337    84 TGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-123 8.73e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 85.19  E-value: 8.73e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGV 82
Cdd:cd18242     4 HAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTE 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNC 123
Cdd:cd18242    84 TVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
PHA02713 PHA02713
hypothetical protein; Provisional
 3-504 3.97e-19

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 90.84  E-value: 3.97e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVND-ERIDAHRIILSGASEYFSILFSSNFIDSD-NYEVNLSHLDYQCINELINYIY 80
Cdd:PHA02713    8 HNRRVVSNISNLLDDDILCDVIITIGDgEEIKAHKTILAAGSKYFRTLFTTPMIIRDlVTRVNLQMFDKDAVKNIVQYLY 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  81 GvpLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCIDVYMYAIEYNNKKIETACFDIILQNILLLINNENFK 160
Cdd:PHA02713   88 N--RHISSMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMYHRLYEMSHIPIVKYIKRMLMSNIPTLITTDAFK 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 161 HLTEESMIKILR-DDRLNIKNEDFSPLILIKWLEctQNPCSVE----LLRCLRITLLSPQIIKALYNHHLIKSQDECLTF 235
Cdd:PHA02713  166 KTVFEILFDIIStNDNVYLYREGYKVTILLKWLE--YNYITEEqllcILSCIDIQNLDKKSRLLLYSNKTINMYPSCIQF 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 236 LNNISFLEETFPRynSIALISIGIGRSHDNISINCYNNKKNTWDMISA-RRFRCNFAVAVLDNIVYMMGGHGDSLYRMSQ 314
Cdd:PHA02713  244 LLDNKQNRNIIPR--QLCLVCHDTKYNVCNPCILVYNINTMEYSVISTiPNHIINYASAIVDNEIIIAGGYNFNNPSLNK 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 315 VIAYDIRNNSWIyDIPSLKYPRSNCRGLTDDEYIYCIGGIRGhhlsfvSDIDRwkpskpywqsyakmrekkcdmgvvmln 394
Cdd:PHA02713  322 VYKINIENKIHV-ELPPMIKNRCRFSLAVIDDTIYAIGGQNG------TNVER--------------------------- 367

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 395 gliyiiggiikdntcTNSVESLSEDGWTIHQPLPIKMSNMATTVHAGKIYISGGYDNTNNIINGQ-------------SN 461
Cdd:PHA02713  368 ---------------TIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTEHIDYTSVHhmnsidmeedthsSN 432

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 1070099198 462 LVFSYDPIYDEWTKLSSLNIPRINPALWSSNNKIYVCGGISDD 504
Cdd:PHA02713  433 KVIRYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVVCDIKDE 475
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-124 8.62e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 82.34  E-value: 8.62e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   8 ISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVPLTLT 87
Cdd:cd18238     3 FKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTLT 82

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1070099198  88 NDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCI 124
Cdd:cd18238    83 VDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCL 119
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 4-124 1.05e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 82.53  E-value: 1.05e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   4 SDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVP 83
Cdd:cd18268     7 SSELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTGE 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1070099198  84 LTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCI 124
Cdd:cd18268    87 ILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCL 127
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-118 1.43e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 81.66  E-value: 1.43e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGV 82
Cdd:cd18338     4 HMKKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTA 83

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEKFILGNL 118
Cdd:cd18338    84 EIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQL 119
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-123 1.53e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 81.81  E-value: 1.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGV 82
Cdd:cd18253     1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNC 123
Cdd:cd18253    81 KVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-124 2.16e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 81.34  E-value: 2.16e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGV 82
Cdd:cd18249     6 HPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYTS 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCI 124
Cdd:cd18249    86 QITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCL 127
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-132 2.94e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 81.48  E-value: 2.94e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYG 81
Cdd:cd18266     7 DHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAVIDFLYS 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1070099198  82 VPLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNcidvYMYAIE 132
Cdd:cd18266    87 SELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEEN----YLYLQE 133
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-114 5.74e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 79.69  E-value: 5.74e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   7 LISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNF--IDSDNYEVNLSHLDYQCINELINYIYGVPL 84
Cdd:cd18245     1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPpkDDGSTYKIELEGISVEVMEEILDYIYTGQI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1070099198  85 TLTNDNVKYILSTADFLQISSAIKECEKFI 114
Cdd:cd18245    81 KLSEDNIQDIVQAADLLLMTDLKDLCCEFL 110
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-124 8.94e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 79.88  E-value: 8.94e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGV 82
Cdd:cd18271     7 HGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYTG 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCI 124
Cdd:cd18271    87 KAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCL 128
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-126 1.07e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 79.32  E-value: 1.07e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYG 81
Cdd:cd18335     1 HHAEQTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1070099198  82 VPLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCIDV 126
Cdd:cd18335    81 GCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-126 2.03e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 78.69  E-value: 2.03e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGV 82
Cdd:cd18276     4 HSLTLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSS 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCIDV 126
Cdd:cd18276    84 DLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-123 8.59e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 76.73  E-value: 8.59e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGV 82
Cdd:cd18250     4 HALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTG 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNC 123
Cdd:cd18250    84 RVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
410-520 1.79e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 79.81  E-value: 1.79e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 410 TNSVESL--SEDGWTIHQPLPIKMSNMATTV-HAGKIYISGGYDNTNNIINGQSNlVFSYDPIYDEWTKLSSLNIPRINP 486
Cdd:COG3055    37 SNSFEVYdpATNTWSELAPLPGPPRHHAAAVaQDGKLYVFGGFTGANPSSTPLND-VYVYDPATNTWTKLAPMPTPRGGA 115

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1070099198 487 ALWSSNNKIYVCGGISDDIRTGMSESYDEEKDCW 520
Cdd:COG3055   116 TALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTW 149
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-124 3.30e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 75.19  E-value: 3.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGV 82
Cdd:cd18265     6 HAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGG 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCI 124
Cdd:cd18265    86 GLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCL 127
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-118 1.13e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 73.57  E-value: 1.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   1 MNHSDALISIINEFRKKRRFCDVIIVV----NDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELI 76
Cdd:cd18248     2 EDHTKEAFQIMNELRLSQQLCDVTLKVkyqdPKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLI 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1070099198  77 NYIYGVPLTLTNDNVKYILSTADFLQISSAIKECEKFILGNL 118
Cdd:cd18248    82 EFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQL 123
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-125 1.47e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 72.92  E-value: 1.47e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSnfiDSDNYEVNLSHLDYQCINELINYIYGV 82
Cdd:cd18260     1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKK---DPSLQRVELNDISPLGLATVITYAYTG 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCID 125
Cdd:cd18260    78 KLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCMY 120
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-118 1.84e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 73.53  E-value: 1.84e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIiNEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYG 81
Cdd:cd18246    22 HYHDAFVSM-NRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYAYT 100

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1070099198  82 VPLTLTNDNVKYILSTADFLQISSAIKECEKFILGNL 118
Cdd:cd18246   101 AEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQL 137
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-122 1.86e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 72.93  E-value: 1.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGV 82
Cdd:cd18251     6 HSQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYTS 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRN 122
Cdd:cd18251    86 ELELSLDNVQETLTAACQLQIPEVIGFCCDFLMSWVDNEN 125
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-124 2.37e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 72.94  E-value: 2.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYG 81
Cdd:cd18259    14 SHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYT 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1070099198  82 VPLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCI 124
Cdd:cd18259    94 GKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCL 136
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-110 3.72e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 71.84  E-value: 3.72e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYG 81
Cdd:cd18328     7 NHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSAILEFAYT 86

                          90       100
                  ....*....|....*....|....*....
gi 1070099198  82 VPLTLTNDNVKYILSTADFLQISSAIKEC 110
Cdd:cd18328    87 STLTITTSNVKHILNAAQMLEIQCIINVC 115
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-124 6.38e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 71.39  E-value: 6.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIV-VNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYG 81
Cdd:cd18252     4 HPADFLDAFRTFYLDGLFTDITLQcASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYT 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1070099198  82 VPLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCI 124
Cdd:cd18252    84 SQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCL 126
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-123 8.96e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 70.99  E-value: 8.96e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVND--ERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIY 80
Cdd:cd18239     6 HSSVVLQGFDQLRGEGLLCDVTLVPGDgdETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNIIDFIY 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1070099198  81 GVPLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNC 123
Cdd:cd18239    86 TAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-125 1.11e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 70.98  E-value: 1.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGV 82
Cdd:cd18264    11 HGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLDFIYTS 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCID 125
Cdd:cd18264    91 WLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENCCF 133
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-110 1.84e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 69.90  E-value: 1.84e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYG 81
Cdd:cd18198     7 DHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTALLEFAYT 86

                          90       100
                  ....*....|....*....|....*....
gi 1070099198  82 VPLTLTNDNVKYILSTADFLQISSAIKEC 110
Cdd:cd18198    87 ATLTVSTANVGDILSAARLLEIPCVSHVC 115
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-114 2.02e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 70.09  E-value: 2.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSnfIDSDNYEVNLSHLDY---QCINELINY 78
Cdd:cd18230     3 SHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQ--VQKTSDQATVTHLDIvtaQGFKAIIDF 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1070099198  79 IYGVPLTLTNDNVKYILSTADFLQISSAIKECEKFI 114
Cdd:cd18230    81 MYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFI 116
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-124 2.74e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 70.40  E-value: 2.74e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNL-SHLDYQCINELINYIY 80
Cdd:cd18267    22 SYADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFhDSIHPEVLELLLDYAY 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1070099198  81 GVPLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCI 124
Cdd:cd18267   102 SSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCL 145
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-110 3.60e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 69.19  E-value: 3.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSN-FIDSDN-YEVNLSHLDyqCINELINYI 79
Cdd:cd18326     7 DHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGaVVDQQNvYEIDFVSAE--ALTALLDFA 84

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1070099198  80 YGVPLTLTNDNVKYILSTADFLQISSAIKEC 110
Cdd:cd18326    85 YTATLTVSTSNVGDILSAARLLEIPAVSHVC 115
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 123-222 6.94e-14

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 67.57  E-value: 6.94e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 123 CIDVYMYAIEYNNKKIETACFDIILQNILLLINNENFKHLTEESMIKILRDDRLNIKNEDFSPLILIKWLECTQN---PC 199
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVErrkKH 80

                          90       100
                  ....*....|....*....|...
gi 1070099198 200 SVELLRCLRITLLSPQIIKALYN 222
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-127 7.81e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 68.70  E-value: 7.81e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDA--------HRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCIN 73
Cdd:cd18273     8 AHARALLAQLKSFYDARLLTDVTIEVNGPGSGPgsgrlfpcNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSESMA 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1070099198  74 ELINYIYGVPLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCIDVY 127
Cdd:cd18273    88 LIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-125 1.40e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 67.68  E-value: 1.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYG 81
Cdd:cd18261    10 SHKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFAYT 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1070099198  82 VPLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCID 125
Cdd:cd18261    90 GQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFNYLD 133
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-127 1.45e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 67.94  E-value: 1.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  19 RFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVPLTLTNDNVKYILSTA 98
Cdd:cd18340    26 KFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFAAA 105

                          90       100
                  ....*....|....*....|....*....
gi 1070099198  99 DFLQISSAIKECEKFILGNLCSRNCIDVY 127
Cdd:cd18340   106 NMFQIPSIFTVCVSFLQKRLCLSNCLAIF 134
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-124 1.73e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 67.34  E-value: 1.73e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNL-SHLDYQCINELINYIY 80
Cdd:cd18254     4 SHPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFhDSLHPEVLELLLDFAY 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1070099198  81 GVPLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCI 124
Cdd:cd18254    84 SSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCL 127
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-114 2.48e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 66.90  E-value: 2.48e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   7 LISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNyEVNLSHLD---YQCINELINYIYGVP 83
Cdd:cd18201     8 LLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCD-QTTVTHLDvvaVQGFSVILDFMYSGN 86

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1070099198  84 LTLTNDNVKYILSTADFLQISSAIKECEKFI 114
Cdd:cd18201    87 LVLTSQNAIEVMSVASYLQMTEVVQSCRNFI 117
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-126 1.50e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 64.62  E-value: 1.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  19 RFCDVIIVVN-DERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVPLTLTNDNVKYILST 97
Cdd:cd18274    21 QLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYTSRVTLTEANVQALFTA 100

                          90       100
                  ....*....|....*....|....*....
gi 1070099198  98 ADFLQISSAIKECEKFILGNLCSRNCIDV 126
Cdd:cd18274   101 ASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-126 2.19e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 64.59  E-value: 2.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  22 DVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVPLTLTNDNVKYILSTADFL 101
Cdd:cd18244    32 DVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMLTVHEILQAAMYV 111

                          90       100
                  ....*....|....*....|....*
gi 1070099198 102 QISSAIKECEKFILGNLCSRNCIDV 126
Cdd:cd18244   112 QLTEVVKFCCSFLLAKICLDNCAEI 136
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-114 2.31e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 63.69  E-value: 2.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFID-SDNYEVNLSHLDYQCINELINYIYG 81
Cdd:cd18329     4 HQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKEtGQPTVATFDVFSPDTFTIILDFVYS 83

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1070099198  82 VPLTLTNDNVKYILSTADFLQISSAIKECEKFI 114
Cdd:cd18329    84 GKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-124 2.58e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 64.25  E-value: 2.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   6 ALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVPLT 85
Cdd:cd18270    12 SLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLA 91

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1070099198  86 LTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCI 124
Cdd:cd18270    92 INDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-112 2.84e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 63.52  E-value: 2.84e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYeVNLSHLDYQCINELINYIYGV 82
Cdd:cd18204     1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSV-IEIDFLRSDIFEEVLNYMYTA 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEK 112
Cdd:cd18204    80 KISVKKEDVNLMMSSGQILGIRFLDKLCSQ 109
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-118 3.94e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 63.34  E-value: 3.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILF-------SSNFIDSDNYEVNLSHLDYQCINEL 75
Cdd:cd18228     2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLvgqasprLVLVSPAGKCVLDLHHVTVTGFAPL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1070099198  76 INYIYGVPLTLTNDNVKYILSTADFLQISSAIKECEKFILGNL 118
Cdd:cd18228    82 LEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-80 4.27e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 62.88  E-value: 4.27e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIY 80
Cdd:cd18223     1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQEIWISSHVLELPDLKAEVFAEILNFIY 78
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-126 4.48e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 63.76  E-value: 4.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   9 SIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVPLTLTN 88
Cdd:cd18272    21 SIMDLCLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRV 100

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1070099198  89 DNVKYILSTADFLQISSAIKECEKFILGNLCSRNCIDV 126
Cdd:cd18272   101 EELQETYEVADMYQLTALFEECSRFLARTVQVRNCLQV 138
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-114 4.73e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 62.64  E-value: 4.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILfssnFIDsdnyEVNLSHLDYQ---CINELINYI 79
Cdd:cd18206     5 HSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRML----FVD----QKDVVHLDISnaaGLGQVLEFM 76

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1070099198  80 YGVPLTLTNDNVKYILSTADFLQISSAIKECEKFI 114
Cdd:cd18206    77 YTAKLSLSPENVDDVLAVATFLQMQDIVTACHALK 111
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-80 7.48e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 62.20  E-value: 7.48e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNfiDSDNYEV-NLSHLDYQCINELINYIY 80
Cdd:cd18209     1 HAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEK--ENESQSVfQLDFCEPDAFENVLNYIY 77
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-126 1.27e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 62.04  E-value: 1.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  19 RFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVPLTLTNDNVKYILSTA 98
Cdd:cd18269    26 KFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQDIFALA 105

                          90       100
                  ....*....|....*....|....*...
gi 1070099198  99 DFLQISSAIKECEKFILGNLCSRNCIDV 126
Cdd:cd18269   106 SRFQIPSIFTVCVSYLQKRLSLSNCLAI 133
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 21-125 1.45e-11

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 61.75  E-value: 1.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  21 CDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVPLTLTNDNVKYILSTADF 100
Cdd:cd18263    14 CDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLSWENLFEATCTALQ 93

                          90       100
                  ....*....|....*....|....*
gi 1070099198 101 LQISSAIKECEKFILGNLCSRNCID 125
Cdd:cd18263    94 LQISGALALCLDFLQREISPARCLD 118
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-114 1.77e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 61.62  E-value: 1.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYfsilFSSNFIDSDNYEVNLS---HLDYQCINELINYI 79
Cdd:cd18277    10 HSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSY----FHSRIVGQADAELNITlpeEVTVKGFEPLIQFA 85

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1070099198  80 YGVPLTLTNDNVKYILSTADFLQISSAIKECEKFI 114
Cdd:cd18277    86 YTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-114 5.00e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 59.89  E-value: 5.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFssnfidSDNYEVNLSHLDY------QCINELI 76
Cdd:cd18215     2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIF------TDQLKNNVSVINLdpeiepEGFRILL 75

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1070099198  77 NYIYGVPLTLTNDNVKYILSTADFLQISSAIKECEKFI 114
Cdd:cd18215    76 DFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 113
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 4-124 6.81e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 59.86  E-value: 6.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   4 SDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVP 83
Cdd:cd18236     8 SLVLQNGLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSK 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1070099198  84 LTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCI 124
Cdd:cd18236    88 VLITKQNVQRVLEAASLFQFLRMVDACASFLTEALHPENCV 128
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-109 7.87e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 59.56  E-value: 7.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYG 81
Cdd:cd18287     4 DHVHFLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYT 83

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1070099198  82 VPLTLTN---DNVKYILSTA---DFLQISSAIKE 109
Cdd:cd18287    84 GRLTLTDlkeDVLLDVLGLAhqyGFEELEAAISD 117
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 20-110 9.71e-11

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 58.51  E-value: 9.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  20 FCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVPLTLTNDNVKYILSTAD 99
Cdd:cd18314     6 FSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLAS 85

                          90
                  ....*....|.
gi 1070099198 100 FLQISSAIKEC 110
Cdd:cd18314    86 KYQVPDLEKLC 96
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-114 1.17e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 58.97  E-value: 1.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDS-DNYEVNLSHLDYQCINELINYIYG 81
Cdd:cd18199     1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTgRPSTASFDVFSSDAFSIILDFVYS 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1070099198  82 VPLTLTNDNVKYILSTADFLQISSAIKECEKFI 114
Cdd:cd18199    81 GKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-112 3.13e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 58.05  E-value: 3.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYF-SILFSSNFIDSDNYEVNLShldyqCINELINYIY 80
Cdd:cd18334     3 NHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFkSLVLHDNLINLDTDMVNPT-----VFRQILDFIY 77

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1070099198  81 GVPLtLTND-----NVKYILSTADFLQISSAIKECEK 112
Cdd:cd18334    78 TGKL-LTSDqpgeqNFNALLTAASYLQLHDLAALCRK 113
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-126 3.29e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 58.32  E-value: 3.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   5 DALISIINEfrkkRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVPL 84
Cdd:cd18341    16 DGLKELLDE----NKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYSAEI 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1070099198  85 TLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCIDV 126
Cdd:cd18341    92 DLNDGNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-114 3.30e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 57.77  E-value: 3.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVnlshLDYQCINELINYIYG 81
Cdd:cd18208     7 NFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSV----VSVQSVQKLIDFMYS 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1070099198  82 VPLTLTNDNVKYILSTADFLQISSAIKECEKFI 114
Cdd:cd18208    83 GVLRVSQSEALQILTAASILQIKTVIDECTRIV 115
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 4-113 4.06e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 57.30  E-value: 4.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   4 SDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSS-NFIDSDNYEVNLsHLDYQCI---NELINYI 79
Cdd:cd18292     1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNdWWSESKQSEIEL-VEDPECAavfEKFLRYL 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1070099198  80 YGVPLTLTNDNVKYILSTADFLQISSAIKECEKF 113
Cdd:cd18292    80 YTGQISVNLETALPLLMLADKYNVTDLKQLCVDF 113
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 11-111 4.08e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 57.21  E-value: 4.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  11 INEFRKKRRFCDVII-VVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNlSHLDYQCINELINYIYGVPLTLTND 89
Cdd:cd18311     5 LQNLFNKTEYCDLTLqFRDNEQLKVHRLVLSACTDYFNVLEQTCEIVDDTLIMP-NELQADAVVPVINFMYTGQLEFEEK 83

                          90       100
                  ....*....|....*....|..
gi 1070099198  90 NVKYILSTADFLQISSAIKECE 111
Cdd:cd18311    84 SYGKLLRTAKELNMTVLLKLLE 105
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-114 5.16e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 57.67  E-value: 5.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKR-RFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFID-SDNYEVNLSHLDYQCINELINYIY 80
Cdd:cd18207     9 HSADMLHNLNQQRKSGgRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDgGTPRELEMHTISSKVFGDILDFAY 88

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1070099198  81 GVPLTLTNDNVKYILSTADFLQISSAIKECEKFI 114
Cdd:cd18207    89 TSRIVVRLESFPELMTAAKFLLMRSVIDICQEVI 122
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-111 7.05e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 56.69  E-value: 7.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYfsilFSSNFIDSDNYEVNL--SHLDYQCINELINYIY 80
Cdd:cd18217     1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEY----FGAQYKDTEDNIVFLdqSQVSADGFQKLLEFIY 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1070099198  81 GVPLTLTNDNVKYILSTADFLQISSAIKECE 111
Cdd:cd18217    77 TGNLNLDSWNVAEIHQAASYLGMEEVVAKCK 107
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-122 7.15e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 56.90  E-value: 7.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  22 DVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIY--GVP-LTLTNDNVKYILSTA 98
Cdd:cd18297    14 DVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYtgGVEsLDVAQDDALELLRAA 93

                          90       100
                  ....*....|....*....|....
gi 1070099198  99 DFLQISSAIKECEKFILGNLCSRN 122
Cdd:cd18297    94 SFFQLDGLKRHCEILLSQQIDLDN 117
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-124 9.10e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 56.56  E-value: 9.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   7 LISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFsilfsSNFIDSDNYEVNLSHLDYQCINELINYIYGVPLTL 86
Cdd:cd18303     5 LLKTVASLFDKELYSDITIKLADKSIPAHKFVLAARSEKW-----SNENLASTNELDLSDISYEVVLALLRWLYTDELDL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1070099198  87 TNDNVKYI--LSTADFLQISSAIKECEKFILGNLCSRNCI 124
Cdd:cd18303    80 TLDDEFLLelMKAAKRFQLTDLVERCERALMSSVNVDNCI 119
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-108 9.45e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 56.96  E-value: 9.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNfiDSDNYEVNLShLDYQCINELINYIYG 81
Cdd:cd18289    11 NFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGN--SKSAFELPAT-VPPACFQQILSFCYT 87

                          90       100
                  ....*....|....*....|....*..
gi 1070099198  82 VPLTLTNDNVKYILSTADFLQISSAIK 108
Cdd:cd18289    88 GKLTMAASEQLVVMYTAGFLQIQHIVE 114
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-114 1.09e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 56.09  E-value: 1.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   7 LISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEV-NLSHLDYQCINELINYIYGVPLT 85
Cdd:cd18330     5 LLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTaSLDIVTSEAFSIILDFLYSGKLD 84

                          90       100
                  ....*....|....*....|....*....
gi 1070099198  86 LTNDNVKYILSTADFLQISSAIKECEKFI 114
Cdd:cd18330    85 LCSENVIEVMSAASYLQMTDVVNFCKGYI 113
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-113 1.22e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 55.92  E-value: 1.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSsnfiDSDNYEVNLSHLDYQCINELINYIYGV 82
Cdd:cd18232     1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYG----DGTSGSVVLPESFAEVFGLLLDFFYTG 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEKF 113
Cdd:cd18232    77 ELALTRENRDRVLLAAKELRVPEAVELCQRF 107
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-124 1.43e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 56.13  E-value: 1.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  11 INEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDN---YEVNLSHLDYQCINELINYIYGVPLTLT 87
Cdd:cd18258     8 LNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGgekLELTMSNINADVLELLLEFVYTGSLIID 87

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1070099198  88 NDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCI 124
Cdd:cd18258    88 SANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCL 124
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-114 1.48e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 55.99  E-value: 1.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYfsilFSSNFIDSDNYEVNLSHL-DYQCINELINYIY 80
Cdd:cd18214     7 NYGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPF----LRDQFLLNDSREVQISILqNSEVGRQLLLSCY 82

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1070099198  81 GVPLTLTNDNVKYILSTADFLQISSAIKEC----EKFI 114
Cdd:cd18214    83 TGVLEFPEMELVNYLTAASFLQMSHIVERCtqalWKFI 120
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-126 1.51e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 55.57  E-value: 1.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  22 DVIIVVNDERIDAHRIILSGASEYFSILFSSNFidsdnyeVNLSHLDYQCINELINYIYGVPLTLTNDNVKYILSTADFL 101
Cdd:cd18275     6 DLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDI-------LKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFL 78

                          90       100
                  ....*....|....*....|....*
gi 1070099198 102 QISSAIKECEKFILGNLCSRNCIDV 126
Cdd:cd18275    79 QMPCAAQCAVDAVRAQLCLGNCYEV 103
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-115 1.60e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 55.81  E-value: 1.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSnfidSDNYEVNL-SHLDYQCINELINYIY 80
Cdd:cd18290     9 NFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELpAAVQPQSFQQILSFCY 84

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1070099198  81 GVPLTLTNDNVKYILSTADFLQISSAIKECEKFIL 115
Cdd:cd18290    85 TGRLSMNVGDQFLLMYTAGFLQIQEIMEKGTEFFL 119
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 22-101 1.63e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 55.73  E-value: 1.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  22 DVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYG-VPLTLTNDNVKYILSTADF 100
Cdd:cd18286    19 DITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGgVLDLPDDVNLGELLSLADM 98


                  .
gi 1070099198 101 L 101
Cdd:cd18286    99 Y 99
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 13-118 1.85e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 55.32  E-value: 1.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  13 EFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIY--GVPLTLTNDN 90
Cdd:cd18300     2 LFLNKGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYtdQAPILEDGDC 81

                          90       100
                  ....*....|....*....|....*...
gi 1070099198  91 VKyILSTADFLQISSAIKECEKFILGNL 118
Cdd:cd18300    82 VG-LIVLANRLCLPRLVALCEQYIVKEL 108
PHA02790 PHA02790
Kelch-like protein; Provisional
 67-520 2.09e-09

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 60.06  E-value: 2.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  67 LDYQCINELINYIYGVPLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRNCIDVYMYAIEY--NNKKIETACFD 144
Cdd:PHA02790   69 LDIHSLTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFIIYTCINFILRDFRKEYCVECYMMGIEYglSNLLCHTKDFI 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 145 IILQNILLLINNENFKHLteeSMIKILRDDRLNIKNEDFSPLILIKWLECTQNPCSVELL---RCLRITLLSPQIIKAly 221
Cdd:PHA02790  149 AKHFLELEDDIIDNFDYL---SMKLILESDELNVPDEDYVVDFVIKWYMKRRNRLGNLLLlikNVIRSNYLSPRGINN-- 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 222 nhhlIKSQDECLTFlnnisFLEETFPRyNSIALISIGIGRSHDNIsINCYNNKKNTWdmisarrfrcnfavavLDNIVYM 301
Cdd:PHA02790  224 ----VKWILDCTKI-----FHCDKQPR-KSYKYPFIEYPMNMDQI-IDIFHMCTSTH----------------VGEVVYL 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 302 MGGHGDSLYRmSQVIAYDIRNNSWIyDIPSLKYPRSNCRGLTDDEYIYCIGGirghhLSFVSDIDRWKPSKPYWQSYAKM 381
Cdd:PHA02790  277 IGGWMNNEIH-NNAIAVNYISNNWI-PIPPMNSPRLYASGVPANNKLYVVGG-----LPNPTSVERWFHGDAAWVNMPSL 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 382 REKKCDMGVVMLNGLIYIIGGIIKDNTCTNSVESlSEDGWTIHQPLPIKMSNMATTVHAGKIYISG-------GYDNTNN 454
Cdd:PHA02790  350 LKPRCNPAVASINNVIYVIGGHSETDTTTEYLLP-NHDQWQFGPSTYYPHYKSCALVFGRRLFLVGrnaefycESSNTWT 428

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1070099198 455 IINgqsnlvfsyDPIYdewtklsslniPRINPALWSSNNKIYVCGGISDDIRTGMSESYDEEKDCW 520
Cdd:PHA02790  429 LID---------DPIY-----------PRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSW 474
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 123-218 3.19e-09

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 54.27  E-value: 3.19e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  123 CIDVYMYAIEYNNKKIETACFDIILQNILLLINNENFKHLTEESMIKILRDDRLNIKNEDFSPLILIKWLE--CTQNPCS 200
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKhdPEKRREH 80

                           90
                   ....*....|....*....
gi 1070099198  201 V-ELLRCLRITLLSPQIIK 218
Cdd:smart00875  81 LpELLEHVRLPLLSPDYLL 99
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-113 3.41e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 54.80  E-value: 3.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFssnfidSDNYEVN-----LSHLDYQCINELIN 77
Cdd:cd18212     6 HKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMF------ADEGEVGqsiymLEGMVAETFGALLE 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1070099198  78 YIYGVPLTLTNDNVKYILSTADFLQISSAIKECEKF 113
Cdd:cd18212    80 FIYTGCLQVGEKSLEQILATAQFLKVNDLVKAYSDY 115
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-123 3.94e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 55.25  E-value: 3.94e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  12 NEFRKKRRFCDVIIVV---NDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSH------LDYQCINELINYIYGV 82
Cdd:cd18241    15 NEQRKQGLFCDITLAFggaGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKwssepgPDPDTVEAVIQYMYTG 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1070099198  83 PLTLTNDNVKYILSTAD-FLQISsaIKE-CEKFILGNLCSRNC 123
Cdd:cd18241    95 RIRVSTGNVHEVLELADrFLLIR--LKEfCGEFLKKKLNLSNC 135
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-122 4.48e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 55.05  E-value: 4.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNfidsdnyEVNLSHLDYQCINELINYIYGV 82
Cdd:cd18243    15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSIN-------NLVLQGCSSIGLRLVLEYLYTA 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEKFILGNLCSRN 122
Cdd:cd18243    88 NVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-114 4.67e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 54.13  E-value: 4.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSsnfiDSDNYEVNLSHLDYQ---CINELINYI 79
Cdd:cd18233     1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQ----NSSSQKNDVFHLDIKnvgGIGQILDFM 76

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1070099198  80 YGVPLTLTNDNVKYILSTADFLQISSAIKECEKFI 114
Cdd:cd18233    77 YTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFL 111
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-110 5.82e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 54.47  E-value: 5.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEV----NLSHLDY---QCINEL 75
Cdd:cd18327     8 HSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGAgggqDVCELDFvgpEALGAL 87

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1070099198  76 INYIYGVPLTLTNDNVKYILSTADFLQISSAIKEC 110
Cdd:cd18327    88 LEFAYTATLTISSSNMREVLRAARLLEIPCVADAC 122
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 23-101 5.92e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 53.05  E-value: 5.92e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1070099198  23 VIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVPLTLTNDNVKYILSTADFL 101
Cdd:cd01165     1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-80 7.78e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 53.30  E-value: 7.78e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNfidsdNYEVNLSHLDYQCINELINYIY 80
Cdd:cd18219     4 YSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSVA-----GQVVELNFIRADIFAEILNYIY 76
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-114 9.45e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 53.90  E-value: 9.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSsnfIDSDNYEVNLSHLDYQCIN-----ELIN 77
Cdd:cd18196     4 HFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFT---VAEGDQTMNMIQLDSEVVTaeafaALID 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1070099198  78 YIYGVPLTLTNDNVKYILSTADFLQISSAIKECEKFI 114
Cdd:cd18196    81 MMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYL 117
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-125 1.38e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 53.44  E-value: 1.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  13 EFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNfIDSDNYEVNLSHLDYQCINELINYIY-GVP--LTLTND 89
Cdd:cd18351    17 HFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNK-PSAENTCIEISYVKYHIFQLVMQYLYcGGTesLLIKNN 95

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1070099198  90 NVKYILSTADFLQISSAIKECEKFILGNLCSRNCID 125
Cdd:cd18351    96 EIMELLSAAKFFQLEALQRHCEIICAKSINTENCVD 131
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-114 1.48e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 52.63  E-value: 1.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  19 RFCDVIIVVNDER--IDAHRIILSGASEYFSILFSSNFI-DSDNYEVNLSHLDYQCINELINYIYGVPLTLTNDNVKYIL 95
Cdd:cd18294    13 EFSDVKFLVGPERqeIFAHKCILAARCEVFRAMFLTGPQkESTQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNHTVIEVL 92

                          90
                  ....*....|....*....
gi 1070099198  96 STADFLQISSAIKECEKFI 114
Cdd:cd18294    93 AAAVEYGLDELRKLCERFI 111
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-114 1.74e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 52.55  E-value: 1.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGV 82
Cdd:cd18332     2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSGLEARGFQLLLDFMYTS 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEKFI 114
Cdd:cd18332    82 RLPLTPRTVPAVLAAATYLQMEHVVETCRRFI 113
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 4-114 2.01e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 52.55  E-value: 2.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   4 SDALISIiNEFRKKRRFCDVIIVVNDERIDAHRIILSGASEyfsiLFSSNFIDSDNYEVNLSHLDYQCINE----LINYI 79
Cdd:cd18331     9 SDVLLNL-NRLRSRDILTDVVIVVSREQFRAHKTVLMACSG----LFYSIFTDQLKCNLSVINLDPEINPEgfniLLDFM 83

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1070099198  80 YGVPLTLTNDNVKYILSTADFLQISSAIKECEKFI 114
Cdd:cd18331    84 YTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 20-104 2.01e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 51.40  E-value: 2.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  20 FCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNY----EVNLSHLDYqcineLINYIYGVPLTLTNDNVKYIL 95
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEHPViilpDVPYSELKA-----LLDFIYTGEVNVSQEQLESLL 75


                  ....*....
gi 1070099198  96 STADFLQIS 104
Cdd:cd18315    76 KLAELLQIK 84
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-111 2.62e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 52.73  E-value: 2.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYG 81
Cdd:cd18325     5 DHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQLDKRDIVHLNSDIVTAPAFSLLLEFMYE 84

                          90       100       110
                  ....*....|....*....|....*....|
gi 1070099198  82 VPLTLTNDNVKYILSTADFLQISSAIKECE 111
Cdd:cd18325    85 GKLEFSSLPVEDVLAAASYLHMYDIVKVCK 114
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-114 3.78e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 51.85  E-value: 3.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  20 FCDVIIVVNDER--IDAHRIILSGASEYFSILFSSNfIDSDNYEVNLSHLDYQCINELINYIYGVPLTLTNDNVKYILST 97
Cdd:cd18231    14 LCDVDIVLVRQRstFPAHKGVLAAYSQFFHSLFTQN-KQLQRVELSLEALTSQGLQQILNFIYTSKLLVNSCNVQDVLNA 92

                          90
                  ....*....|....*..
gi 1070099198  98 ADFLQISSAIKECEKFI 114
Cdd:cd18231    93 AAVLQMNDIAASCQELI 109
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-112 4.02e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 51.83  E-value: 4.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYF-SILFSSNFIDSDNYEVNLShldyqCINELINYIY 80
Cdd:cd18333     3 SHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLkSLVVHDNLINLDHEMVSPG-----IFRLILDYIY 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1070099198  81 GVPLT----LTNDNVKYILSTADFLQISSAIKECEK 112
Cdd:cd18333    78 TGRLSegdpGSEQNLGAVLAAASYLQIPDLVALCKK 113
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 4-114 6.52e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 51.01  E-value: 6.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   4 SDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFsilfssnfidSDNYEVNLSHLDY------QCINELIN 77
Cdd:cd18229     2 SKSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFF----------HDKLLLGHSEIEVppvvpaQTVRQLVE 71

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1070099198  78 YIYGVPLTLTNDNVKYILSTADFLQISSAIKECEKFI 114
Cdd:cd18229    72 FMYSGSLVVAQSEALQILTAASILQIKTVIDECTQII 108
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-113 6.71e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 50.57  E-value: 6.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  20 FCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDN---YEVNLSHLDYQCINELINYIYGVPLTLTNDNVKYILS 96
Cdd:cd18307     1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATDelsITIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLLK 80

                          90
                  ....*....|....*..
gi 1070099198  97 TADFLQISSAIKECEKF 113
Cdd:cd18307    81 GAKYFNIPRLKDHCVDF 97
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-110 8.46e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 50.99  E-value: 8.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSS-----------NFIDSDNYEvnlshldyq 70
Cdd:cd18224     8 DHPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLSteldvartyvvDFITPANFE--------- 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1070099198  71 cinELINYIYGVPLTLTNDNVKYILSTADFLQISSAIKEC 110
Cdd:cd18224    79 ---KVLSFIYTSELFTDLINVGVIYEVAEKLGMEDLLKAC 115
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-114 1.10e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 50.42  E-value: 1.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNfidSDNYevNLSHLDYQCINELINYIYGV 82
Cdd:cd18205     1 HPTGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRN---SQHY--TLDFLSPKTFQQILEYAYTA 75

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEKFI 114
Cdd:cd18205    76 TLQAKVEDLDDLLYAAEILEIEYLEEQCLKIL 107
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-112 1.12e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 51.19  E-value: 1.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYG 81
Cdd:cd18324     5 DHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLEFMYE 84

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1070099198  82 VPLTLTNDNVKYILSTADFLQISSAIKECEK 112
Cdd:cd18324    85 GKLQFKDLPIEDVLAAASYLHMYDIVKVCKK 115
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-116 1.37e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 50.43  E-value: 1.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSdnyeVNLSHLDYQCINE-LINYIY 80
Cdd:cd18222     7 DFSNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLNEMST----VSISVIKNPTVFEqLLSFCY 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1070099198  81 GVPLTLTNDNVKYILSTADFLQISSAIKECEKFILG 116
Cdd:cd18222    83 TGRICLQLADIISYLTAASFLQMQHIIDKCTQILEG 118
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-104 1.60e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 50.17  E-value: 1.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  20 FCDVIIVVNDERIDAHRIILSGASEYFSILFSS-NFIDSDNYEVNLSHLDYQCINELINYIYGVPLTLTNDNVKYILSTA 98
Cdd:cd18293    15 FCDVLLQAEGESVPAHCCVLSACSPYLTERLSSePPPAGQKVVLELQGLKAHTLLKLVDFLYTSELEVSSEEAQDVLAAA 94


                  ....*.
gi 1070099198  99 DFLQIS 104
Cdd:cd18293    95 RRLQIS 100
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 11-89 1.69e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 50.35  E-value: 1.69e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1070099198  11 INEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVPLTLTND 89
Cdd:cd18358    11 IKECLSKGTFSDVTFKLDDGTINAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQLSPTAD 89
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-108 1.95e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 49.80  E-value: 1.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKR-RFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNfidSDNYEVNLSHLDYQCINELINYIYG 81
Cdd:cd18226     4 YNKNLLKYLNDDRQKQsSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLSKN---PNTDAVTLDHVSYSVFQHLLEFLYT 80

                          90       100
                  ....*....|....*....|....*..
gi 1070099198  82 VPLTLTNDNVKYILSTADFLQISSAIK 108
Cdd:cd18226    81 SEFFVYENEIPLVLEAAKFLDIIDAVK 107
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-111 2.46e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 49.46  E-value: 2.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILF-SSNFIDSDNYEVNLSHLDYQCINELINYIYG 81
Cdd:cd18202     2 HGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFiEKGAVSSHEAVVDLSGFCKSSFLPLLEFAYT 81

                          90       100       110
                  ....*....|....*....|....*....|
gi 1070099198  82 VPLTLTNDNVKYILSTADFLQISSAIKECE 111
Cdd:cd18202    82 SELTFDFCSMAEVAMLARHLFMNEVLEICE 111
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-114 3.68e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 49.18  E-value: 3.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNfiDSDNYEVNL-SHLDYQCINELINYIYG 81
Cdd:cd18278    14 HCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQ--TENDLVVSLpEEVTARGFGPLLQFAYT 91

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1070099198  82 VPLTLTNDNVKYILSTADFLQISSAIKECEKFI 114
Cdd:cd18278    92 AKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 20-119 4.09e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 48.83  E-value: 4.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  20 FCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNY-----EVNLSHLDYQCINELINYIYGVPLTLTNDNVKYI 94
Cdd:cd18296    17 FPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENngsipVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDV 96

                          90       100
                  ....*....|....*....|....*
gi 1070099198  95 LSTADFLQISSAIKECEKFILGNLC 119
Cdd:cd18296    97 LYVADMYLLPGLKRLCGTVLAQSLD 121
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-110 4.99e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 48.72  E-value: 4.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNfiDSDNYEVNLSHlDYQCINELINYIYGV 82
Cdd:cd18203     8 HEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLN--PSSELQVSLMH-SSRVVADLLLSCYTG 84

                          90       100
                  ....*....|....*....|....*...
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKEC 110
Cdd:cd18203    85 ALEFSVRDIVNYLTAASYLQMEHVVEKC 112
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-112 5.34e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 48.40  E-value: 5.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSnfiDSDNYEVNLSHLDYQCINELINYIYGV 82
Cdd:cd18218     1 HSDRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTN---PNPGQWCLGEGISPSTFKQLLDFVYGE 77

                          90       100       110
                  ....*....|....*....|....*....|
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEK 112
Cdd:cd18218    78 SVEVQPGELRPLLEAARALEVESLEEACWR 107
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-118 5.67e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 48.28  E-value: 5.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGAseyfSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYG 81
Cdd:cd18225     5 NYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAAS----SLLFKSLLDSTDTISIDASVVSPEEFALLLEMVYT 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1070099198  82 VPLTLTNDNVKYILSTADFLQISSAIKECeKFILGNL 118
Cdd:cd18225    81 GKLPPGKHNFTKIISVADSLQMFDVAVSC-KNLLTSL 116
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-86 5.85e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 48.74  E-value: 5.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSS-------------NFIDSDNYEVNLSHLDY 69
Cdd:cd18195     1 HAGALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSplplgaaavaaapGATQSPERVLELPGVKA 80

                          90
                  ....*....|....*..
gi 1070099198  70 QCINELINYIYGVPLTL 86
Cdd:cd18195    81 GVFSDVLNFIYSSRVAL 97
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-114 9.29e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 47.08  E-value: 9.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  21 CDVIIVVNDERIDAHRIILSGASEYFSILFSSNfIDSDnYEVNL-SHLDYQCINELINYIYGVPLTLTNDNVKYILSTAD 99
Cdd:cd18955     2 CDVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQ-TDGD-LVITLpEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCAE 79

                          90
                  ....*....|....*
gi 1070099198 100 FLQISSAIKECEKFI 114
Cdd:cd18955    80 FLGVHNIEKACFDFL 94
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-121 9.71e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 47.91  E-value: 9.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNfidsdnyevNLSHLDYQCIN-----ELI 76
Cdd:cd18216     2 SHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHD---------NLIHLDQDMVSptvfqQIL 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1070099198  77 NYIYG---VPLTLTNDNVKYILSTADFLQISSaikecekfiLGNLCSR 121
Cdd:cd18216    73 DFIYTgklLDSLFEEPNLSEVLAAANYLQLPD---------LAALCRS 111
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 22-112 1.11e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 47.63  E-value: 1.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  22 DVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDnyEVNLSH--LDYQCINELINYIYGVPLTLTNDNVKYILSTAD 99
Cdd:cd18295    21 DVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKR--EINLKHplVNPDAFRALLQYLYTGRLEIHVDDVEDCKRLAK 98

                          90
                  ....*....|...
gi 1070099198 100 FLQISSAIKECEK 112
Cdd:cd18295    99 QCRLEELIEELEA 111
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 14-121 1.24e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 46.94  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  14 FRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNfIDSDNYEVNLSHL--DYQCINELINYIYGVPLTLTNDNV 91
Cdd:cd18312     3 FRDTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLASSS-SESDPSEIELNDFpgGAEAFELVAKFCYGMPINLTATNV 81

                          90       100       110
                  ....*....|....*....|....*....|
gi 1070099198  92 KYILSTADFLQISsaikecEKFILGNLCSR 121
Cdd:cd18312    82 VGLRCAAEYLEMT------ESGNLGNLIDK 105
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 20-100 1.43e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 47.38  E-value: 1.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  20 FCDVIIVVNDERIDAHRIILSGASEYFSILFSSnFIDSDNyEVNLSHLDY----QCINELINYIYGVPLTLTNDNVKYIL 95
Cdd:cd18309    20 FCDITLLLDGHPIPAHKAILAARCSYFEAMFRS-FMPEDN-TVNISIGEMvpsrQAFDSLLRYIYYGDVTMPPEDSLYLF 97


                  ....*
gi 1070099198  96 STADF 100
Cdd:cd18309    98 SAPYF 102
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-112 1.58e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 47.51  E-value: 1.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGV 82
Cdd:cd18194     6 HSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRLDKRDLVRLNSDIVTAPAFGLLLDFMYEG 85

                          90       100       110
                  ....*....|....*....|....*....|
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEK 112
Cdd:cd18194    86 RLALRDLPVEDVLAAASYLHMYDIVKVCKG 115
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 22-122 1.87e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 47.09  E-value: 1.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  22 DVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVPLTLTNDNVKYILSTADFL 101
Cdd:cd18352    15 DVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAADQY 94

                          90       100
                  ....*....|....*....|.
gi 1070099198 102 QISSAIKECEKFILGNLCSRN 122
Cdd:cd18352    95 LLEGLKRLCEYTIAQDLTLEN 115
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-111 5.52e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 45.38  E-value: 5.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFsSNFIDSDNYEVN-LSHLDYQcinELINYIYG 81
Cdd:cd18221     1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFF-QDFTQEPLVEIEgVSNMAFR---HLIEFTYT 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1070099198  82 VPLTLTN-DNVKYILSTADFLQISSAIKECE 111
Cdd:cd18221    77 AKLMVQGeEEANDVWKAAEYLQMQEAIKALE 107
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-122 5.68e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 45.89  E-value: 5.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  21 CDVIIVV----NDERIDAHRIILSGASEYFSILFSSNFIDSDNyEVNLSHLDYQCINELINYIYGVPLTLTNDNVKYILS 96
Cdd:cd18281    23 SDVHFIVgkgdNEQRIPAHKFVLSIGSAVFDAMFNGGMATTSA-EIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLY 101

                          90       100
                  ....*....|....*....|....*.
gi 1070099198  97 TADFLQISSAIKECEKFILGNLCSRN 122
Cdd:cd18281   102 TAKKYAVPALESACVEFLKKNLSSDN 127
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-116 7.65e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 45.40  E-value: 7.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHldyQCINELINYIYGV 82
Cdd:cd18220     8 YSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIKNP---NVFEQLLSFCYTG 84

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1070099198  83 PLTLTNDNVKYILSTADFLQISSAIKECEKFILG 116
Cdd:cd18220    85 RMSLQLKDVVSFLTAASFLQMQCVIDKCTQILES 118
Kelch smart00612
Kelch domain;
442-488 7.81e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.93  E-value: 7.81e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1070099198  442 KIYISGGYDNTNNiingqSNLVFSYDPIYDEWTKLSSLNIPRINPAL 488
Cdd:smart00612   1 KIYVVGGFDGGQR-----LKSVEVYDPETNKWTPLPSMPTPRSGHGV 42
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-112 7.89e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 45.59  E-value: 7.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYG 81
Cdd:cd18323     5 DHSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFHMFYKEQLDKRDLVCINNEIVTAPAFSLLLEFMYE 84

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1070099198  82 VPLTLTNDNVKYILSTADFLQISSAIKECEK 112
Cdd:cd18323    85 GRLSFNDTPVEDVLAAASYLHMNDIVKVCKK 115
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 20-122 1.04e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 44.66  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  20 FCDVIIVVND-ERIDAHRIILSGASEYFSILFSSNFIDSdnyeVNLSHLDY----QCINELINYIYgvplTLTNDNVKY- 93
Cdd:cd18302     5 LYDVTIVSEDgKEFPCHKCVLVARLEYFHSMLSSSWIEA----SSCSALTMpipsDILEIILDYLY----TDEASAVKEs 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1070099198  94 --------ILSTADFLQISSAIKECEKFILGNLCSRN 122
Cdd:cd18302    77 qnveflcnVLVIADQLLITRLKEICEVALVELLSLKN 113
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 432-480 1.46e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.21  E-value: 1.46e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1070099198 432 SNMATTVHAGKIYISGGYDNTNNiingqSNLVFSYDPIYDEWTKLSSLN 480
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDGNQS-----LNSVEVYDPETNTWSKLPSMP 46
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 121-209 1.94e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 43.69  E-value: 1.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 121 RNCIDVYMYAIEYNNKKIETACFDIILQNILLLINNENFKHLTEESMIKILRDDRLNIKNEDFSPLILIKWLECTQNPCS 200
Cdd:cd18483     4 QNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQSKRE 83

                          90
                  ....*....|...
gi 1070099198 201 VEL----LRCLRI 209
Cdd:cd18483    84 MHLpeifAKCIRM 96
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-114 2.39e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 43.69  E-value: 2.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYF---------SILFSSNFIDSDNYEvnlshldyqcin 73
Cdd:cd18200     1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFhdklllndtNCLVLPSVIEAAAFE------------ 68

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1070099198  74 ELINYIYGVPLTLTNDNVKYILSTADFLQISSAIKECEKFI 114
Cdd:cd18200    69 NLLQLIYSGRLTLCMDALPSHLLVASGLQMWQVVDRCSELL 109
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 287-333 3.18e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.44  E-value: 3.18e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1070099198 287 RCNFAVAVLDNIVYMMGGHgDSLYRMSQVIAYDIRNNSWIYdIPSLK 333
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGF-DGNQSLNSVEVYDPETNTWSK-LPSMP 46
Kelch_6 pfam13964
Kelch motif;
286-336 3.58e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.17  E-value: 3.58e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1070099198 286 FRCNFAVAVLDNIVYMMGGHGDSLYRMSQVIAYDIRNNSWIYdIPSLKYPR 336
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEE-LPPLPTPR 50
BTB2_POZ_RHOBTB2 cd18359
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 11-80 4.71e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349668 [Multi-domain]  Cd Length: 124  Bit Score: 43.07  E-value: 4.71e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  11 INEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIY 80
Cdd:cd18359    11 VKECLAKGTFSDVTFMLDDGTISAHKPLLISSCDWMAAMFGGPFVESSTTEVVFPYTSRSSMRAVLEYLY 80
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-122 7.26e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 42.68  E-value: 7.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  18 RRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIY--GVP-LTLTNDNvkyI 94
Cdd:cd18343    19 SRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYtgKAPnLDKMADN---L 95

                          90       100
                  ....*....|....*....|....*...
gi 1070099198  95 LSTADFLQISSAIKECEKFILGNLCSRN 122
Cdd:cd18343    96 LAAADKYALERLKVMCEEALCNNLSVEN 123
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-117 7.96e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 42.62  E-value: 7.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFS---ILFSSNFIdsdnyeVNLSHLDYQCINELINY 78
Cdd:cd18227     7 DFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCdqvLLKNSRRI------VLPDVMNPRVFENILLS 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1070099198  79 IYGVPLTLTNDNVKYILSTADFLQISSAIKECEKFILGN 117
Cdd:cd18227    81 CYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELLEGN 119
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 22-80 1.06e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 41.50  E-value: 1.06e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1070099198  22 DVIIVVNDERIDAHRIILSGASEYFSILF-SSNFIDSDNY---EVNLSHLDYQCINELINYIY 80
Cdd:cd18301    20 DVVFQVGGKTFPAHKFILASRSDYFRKLFlSSLLTSEDAVgcdVVHIEKVPPEIFEQLLQFIY 82
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-122 2.43e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 40.99  E-value: 2.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  16 KKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVPLTLTNDNVKYIL 95
Cdd:cd18345    14 ERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGKAPNLDKMADDLL 93

                          90       100
                  ....*....|....*....|....*..
gi 1070099198  96 STADFLQISSAIKECEKFILGNLCSRN 122
Cdd:cd18345    94 AAADKYALERLKVMCEEALCSNLSVEN 120
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-111 3.01e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 40.95  E-value: 3.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   3 HSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDS-DNYEVNLSHLDYQCINELINYIYG 81
Cdd:cd18956     6 HGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGGrDTVRLNGDIVTAPAFGRLLDFMYE 85

                          90       100       110
                  ....*....|....*....|....*....|
gi 1070099198  82 VPLTLTNDNVKYILSTADFLQISSAIKECE 111
Cdd:cd18956    86 GRLDLRSLPVEDVLAAASYLHMYDIVKVCK 115
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-110 3.26e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 40.62  E-value: 3.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   5 DALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYfsilFSSNFIDSDNYEVNLSHLDYQCINE--LINYIYGV 82
Cdd:cd18197    10 DAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTF----MRDQFLLNQSKQVRITILQSAEVGRklLLSCYTGA 85

                          90       100
                  ....*....|....*....|....*...
gi 1070099198  83 PLTLTNDNVKYiLSTADFLQISSAIKEC 110
Cdd:cd18197    86 LEVKKKELLKY-LTAASYLQMVHIVEKC 112
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 19-104 5.97e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 39.50  E-value: 5.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  19 RFCDVIIVVND-ERIDAHRIILSGASEYFSILFSSNFIdsdnyeVNL-SHLDYQCINELINYIYGVPLTLTNDNVKYILS 96
Cdd:cd18299    11 SCADVVFILQGgVRIFAHRIVLAAASSVFADLFLMMTV------VTLdSDITPEAFRRVLEFLYTGVLDENEDDLKELKD 84


                  ....*...
gi 1070099198  97 TADFLQIS 104
Cdd:cd18299    85 AAELLELF 92
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 335-382 8.57e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 8.57e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1070099198 335 PRSNCRGLTDDEYIYCIGGIRGHhlSFVSDIDRWKPSKPYWQSYAKMR 382
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGN--QSLNSVEVYDPETNTWSKLPSMP 46
PLN02153 PLN02153
epithiospecifier protein
 421-502 1.02e-03

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 41.51  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198 421 WTIHQP---------LPIKMSNMATtvhagKIYISGGYDNTNNIINgqsnlVFSYDPIYDEWTKLSSLNI-----PRINP 486
Cdd:PLN02153   62 WSIAPAngdvpriscLGVRMVAVGT-----KLYIFGGRDEKREFSD-----FYSYDTVKNEWTFLTKLDEeggpeARTFH 131

                          90
                  ....*....|....*.
gi 1070099198 487 ALWSSNNKIYVCGGIS 502
Cdd:PLN02153  132 SMASDENHVYVFGGVS 147
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-122 1.28e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 38.93  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  19 RFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGVPLTLTNDNVKYILSTA 98
Cdd:cd18342    21 RFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAA 100

                          90       100
                  ....*....|....*....|....
gi 1070099198  99 DFLQISSAIKECEKFILGNLCSRN 122
Cdd:cd18342   101 DKYALERLKVMCEDALCSNLSVEN 124
Kelch_6 pfam13964
Kelch motif;
436-483 1.63e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.54  E-value: 1.63e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1070099198 436 TTVHAGKIYISGGYDNTNNiingQSNLVFSYDPIYDEWTKLSSLNIPR 483
Cdd:pfam13964   7 VVSVGGYIYVFGGYTNASP----ALNKLEVYNPLTKSWEELPPLPTPR 50
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 157-217 1.77e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 38.06  E-value: 1.77e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1070099198 157 ENFKHLTEESMIKILRDDRLNIKNEDFSPLILIKWL---ECTQNPCSVELLRCLRITLLSPQII 217
Cdd:cd18457    40 EEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVkydRENREEYLPELLSKVRLPLLRPQFL 103
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-80 2.19e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 38.00  E-value: 2.19e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1070099198  22 DVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIY 80
Cdd:cd18298    14 DLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLY 72
Kelch smart00612
Kelch domain;
299-339 2.23e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 36.00  E-value: 2.23e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1070099198  299 VYMMGGHgDSLYRMSQVIAYDIRNNSWiYDIPSLKYPRSNC 339
Cdd:smart00612   2 IYVVGGF-DGGQRLKSVEVYDPETNKW-TPLPSMPTPRSGH 40
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-80 2.66e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 37.89  E-value: 2.66e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1070099198  19 RFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIY 80
Cdd:cd18279    17 RFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIY 78
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 1-112 4.03e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 37.53  E-value: 4.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198   1 MNHSDALISIINEFRKKR---RFCDVIIVVN----DERIDAHRIILSGASEYFSILF-SSNFIDSDNYEVNLSHLDYQCI 72
Cdd:cd18211     3 LESKSAPSNLLNEMHKLRllgHLCDVTVQVEhqgsKEEFSAHKAVLAASSKYFKEVFlNEKISDGKNTNVMLNEIYTADF 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1070099198  73 NELINYIYGVPLTLTNDNVKYILSTADFLQISSAIKECEK 112
Cdd:cd18211    83 ASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSETCFQ 122
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-80 4.09e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 37.49  E-value: 4.09e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1070099198   2 NHSDALISIINEFRKKRRFCDVIIVVNDERIDAHRIILSGASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIY 80
Cdd:cd18192     3 SHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSNMKISAECFDLILQFMY 81
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-117 5.71e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 36.87  E-value: 5.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1070099198  22 DVIIVVNDERIDAHRIILSgASEYFSILFSSNFIDSDNYEVNLSHLDYQCINELINYIYGV----PLTLTNDNVKYILST 97
Cdd:cd18305    17 DITICALGREWKLHKIYLC-QSGYFASMFSGSWKESKETVINLEIPDDNITVEALNVVFGSlyrdEIEIKPSRVVSILAA 95

                          90       100
                  ....*....|....*....|
gi 1070099198  98 ADFLQISSAIKECEKFILGN 117
Cdd:cd18305    96 ATLLQLDGLIQQCSEVMKET 115
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 118-193 8.04e-03

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 35.40  E-value: 8.04e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1070099198 118 LCSRNCIDVYMYAIEYNNKKIETACFDIILQNILLLINNENFKHLTEESMIKILRDDRLNIKNEDFSPLILIKWLE 193
Cdd:cd18503     1 LDRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTE 76
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 118-191 8.39e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 35.66  E-value: 8.39e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1070099198 118 LCSRNCIDVYMYAIEYNNKKIETACFDIILQN-ILLLINNENFKHLTEESMIKILRDDRLNIKNEDFSPLILIKW 191
Cdd:cd18450     1 LTPENCIGIRKFARYYFCPELERKAYRYILRNfEEVAKDSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKW 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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