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Chain A, H PROTEIN OF THE GLYCINE CLEAVAGE SYSTEM
glycine cleavage system protein H( domain architecture ID 10785558)
glycine cleavage system protein H plays a role in the degradation of glycine by shuttling the methylamine group of glycine from P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase).
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
GcvH | COG0509 | Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; ... |
1-127 | 2.20e-67 | |||
Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; Glycine cleavage system protein H (lipoate-binding) is part of the Pathway/BioSystem: Glycine cleavage : Pssm-ID: 440275 Cd Length: 128 Bit Score: 199.19 E-value: 2.20e-67
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Name | Accession | Description | Interval | E-value | |||
GcvH | COG0509 | Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; ... |
1-127 | 2.20e-67 | |||
Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; Glycine cleavage system protein H (lipoate-binding) is part of the Pathway/BioSystem: Glycine cleavage Pssm-ID: 440275 Cd Length: 128 Bit Score: 199.19 E-value: 2.20e-67
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PRK01202 | PRK01202 | glycine cleavage system protein GcvH; |
1-126 | 1.37e-65 | |||
glycine cleavage system protein GcvH; Pssm-ID: 234918 Cd Length: 127 Bit Score: 194.61 E-value: 1.37e-65
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GCV_H | pfam01597 | Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the ... |
7-127 | 4.39e-57 | |||
Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. Pssm-ID: 396258 Cd Length: 122 Bit Score: 173.29 E-value: 4.39e-57
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GCS_H | cd06848 | Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage ... |
9-103 | 5.45e-47 | |||
Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-proteins) which catalyzes the oxidative cleavage of glycine. The H-protein shuttles the methylamine group of glycine from the P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase) via a lipoyl group, attached to a completely conserved lysine residue. Pssm-ID: 133457 [Multi-domain] Cd Length: 96 Bit Score: 146.52 E-value: 5.45e-47
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gcvH | TIGR00527 | glycine cleavage system H protein; This model represents the glycine cleavage system H protein, ... |
2-127 | 2.81e-44 | |||
glycine cleavage system H protein; This model represents the glycine cleavage system H protein, which shuttles the methylamine group of glycine from the P protein to the T protein. The mature protein is about 130 residues long and contains a lipoyl group covalently bound to a conserved Lys residue. The genome of Aquifex aeolicus contains one protein scoring above the trusted cutoff and clustering with other bacterial H proteins, and four more proteins clustering together and scoring below the trusted cutoff; it seems doubtful that all of these homologs are authentic H protein. The Chlamydial homolog of H protein is nearly as divergent as the Aquifex outgroup, is not accompanied by P and T proteins, is not included in the seed alignment, and consequently also scores below the trusted cutoff. [Energy metabolism, Amino acids and amines] Pssm-ID: 200024 Cd Length: 128 Bit Score: 141.13 E-value: 2.81e-44
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Name | Accession | Description | Interval | E-value | |||
GcvH | COG0509 | Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; ... |
1-127 | 2.20e-67 | |||
Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; Glycine cleavage system protein H (lipoate-binding) is part of the Pathway/BioSystem: Glycine cleavage Pssm-ID: 440275 Cd Length: 128 Bit Score: 199.19 E-value: 2.20e-67
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PRK01202 | PRK01202 | glycine cleavage system protein GcvH; |
1-126 | 1.37e-65 | |||
glycine cleavage system protein GcvH; Pssm-ID: 234918 Cd Length: 127 Bit Score: 194.61 E-value: 1.37e-65
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GCV_H | pfam01597 | Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the ... |
7-127 | 4.39e-57 | |||
Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. Pssm-ID: 396258 Cd Length: 122 Bit Score: 173.29 E-value: 4.39e-57
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GCS_H | cd06848 | Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage ... |
9-103 | 5.45e-47 | |||
Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-proteins) which catalyzes the oxidative cleavage of glycine. The H-protein shuttles the methylamine group of glycine from the P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase) via a lipoyl group, attached to a completely conserved lysine residue. Pssm-ID: 133457 [Multi-domain] Cd Length: 96 Bit Score: 146.52 E-value: 5.45e-47
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gcvH | TIGR00527 | glycine cleavage system H protein; This model represents the glycine cleavage system H protein, ... |
2-127 | 2.81e-44 | |||
glycine cleavage system H protein; This model represents the glycine cleavage system H protein, which shuttles the methylamine group of glycine from the P protein to the T protein. The mature protein is about 130 residues long and contains a lipoyl group covalently bound to a conserved Lys residue. The genome of Aquifex aeolicus contains one protein scoring above the trusted cutoff and clustering with other bacterial H proteins, and four more proteins clustering together and scoring below the trusted cutoff; it seems doubtful that all of these homologs are authentic H protein. The Chlamydial homolog of H protein is nearly as divergent as the Aquifex outgroup, is not accompanied by P and T proteins, is not included in the seed alignment, and consequently also scores below the trusted cutoff. [Energy metabolism, Amino acids and amines] Pssm-ID: 200024 Cd Length: 128 Bit Score: 141.13 E-value: 2.81e-44
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PRK13380 | PRK13380 | glycine cleavage system protein H; Provisional |
9-130 | 2.98e-40 | |||
glycine cleavage system protein H; Provisional Pssm-ID: 237370 Cd Length: 144 Bit Score: 131.28 E-value: 2.98e-40
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Biotinyl_lipoyl_domains | cd06663 | Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the ... |
24-103 | 2.80e-19 | |||
Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, or methylamine, respectively, between components of the complex/protein via a biotinyl or lipoyl group, which is covalently attached to a highly conserved lysine residue. Pssm-ID: 133456 [Multi-domain] Cd Length: 73 Bit Score: 75.56 E-value: 2.80e-19
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PRK00624 | PRK00624 | glycine cleavage system protein H; Provisional |
9-114 | 4.33e-17 | |||
glycine cleavage system protein H; Provisional Pssm-ID: 167014 Cd Length: 114 Bit Score: 71.40 E-value: 4.33e-17
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Blast search parameters | ||||
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