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Conserved domains on  [gi|1063864654|ref|XP_018005857|]
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PHO85 cyclin-6 [Cyphellophora attinorum]

Protein Classification

cyclin family protein( domain architecture ID 1750054)

cyclin family protein may associate with and activate its cognate cyclin-dependent kinase (CDK)

CATH:  1.10.472.10
Gene Ontology:  GO:0000079|GO:0019901|GO:0007049
PubMed:  14744433|30185601|15269391|15840440
SCOP:  4001102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 170-409 1.00e-36

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member pfam08613:

Pssm-ID: 477360  Cd Length: 149  Bit Score: 132.19  E-value: 1.00e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063864654 170 TDIIEMVAGLLTKITHTNDrnhdhiNRPIPLPEDQANMSPQM--TSVLAFHGKNVPSITILSYLSRIHKYCPTTYEVFLS 247
Cdd:pfam08613   1 DKLIQMISGELDRLIANND------GTATASSDAQSPLEPSQlqSPELSFYSKAVPAISIGAYLSRIQKFCPSSPAVLLS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063864654 248 LLVYFDRMtevvnknllmqsqsQRRdpnaseaslpsmttgestlsleghdpaptppqsgspnphepstpteappsppmea 327
Cdd:pfam08613  75 ALIYLDRL--------------VKR------------------------------------------------------- 85

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063864654 328 TLAEAgnfFVVDSFNIHRLVIAGVTCASKFFSDVFYTNSRYAKasatrsrviptdisqVGGLPLVELNHLELQFLILNNF 407
Cdd:pfam08613  86 CDSEA---FVVTSANAHRLLITAVTVATKFLSDGFYSNSRFAK---------------VGGISLHELNHLEIDFLFLVDF 147


                  ..
gi 1063864654 408 RL 409
Cdd:pfam08613 148 DL 149
 
Name Accession Description Interval E-value
Cyclin pfam08613
Cyclin; This family includes many different cyclin proteins. Members include the G1/S-specific ...
 170-409 1.00e-36

Cyclin; This family includes many different cyclin proteins. Members include the G1/S-specific cyclin pas1, and the phosphate system cyclin PHO80/PHO85.


Pssm-ID: 400780  Cd Length: 149  Bit Score: 132.19  E-value: 1.00e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063864654 170 TDIIEMVAGLLTKITHTNDrnhdhiNRPIPLPEDQANMSPQM--TSVLAFHGKNVPSITILSYLSRIHKYCPTTYEVFLS 247
Cdd:pfam08613   1 DKLIQMISGELDRLIANND------GTATASSDAQSPLEPSQlqSPELSFYSKAVPAISIGAYLSRIQKFCPSSPAVLLS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063864654 248 LLVYFDRMtevvnknllmqsqsQRRdpnaseaslpsmttgestlsleghdpaptppqsgspnphepstpteappsppmea 327
Cdd:pfam08613  75 ALIYLDRL--------------VKR------------------------------------------------------- 85

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063864654 328 TLAEAgnfFVVDSFNIHRLVIAGVTCASKFFSDVFYTNSRYAKasatrsrviptdisqVGGLPLVELNHLELQFLILNNF 407
Cdd:pfam08613  86 CDSEA---FVVTSANAHRLLITAVTVATKFLSDGFYSNSRFAK---------------VGGISLHELNHLEIDFLFLVDF 147


                  ..
gi 1063864654 408 RL 409
Cdd:pfam08613 148 DL 149
CYCLIN_ScPCL7-like cd20558
cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins; ...
 223-412 7.32e-36

cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins; ScPCL7, also called PHO85-associated protein 1, is a cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL6, ScPCL7 controls glycogen phosphorylase and glycogen synthase activities in response to nutrient availablility. This family also includes Schizosaccharomyces pombe PHO85 cyclin-like protein Psl1 (SpPsl1) and Arabidopsis thaliana PHO80-like proteins, P-type cyclins (CYCPs). SpPsl1 is the cyclin partner of the CDK pef1 (PHO85 homolog). CYCPs may be involved in cell division, cell differentiation, and the nutritional status of the cell in Arabidopsis thaliana. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410261  Cd Length: 101  Bit Score: 128.06  E-value: 7.32e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063864654 223 PSITILSYLSRIHKYCPTTYEVFLSLLVYFDRmtevvnknllmqsqsqrrdpnaseaslpsmttgestlsleghdpaptp 302
Cdd:cd20558     1 PSISILDYLERIVKYCPCSPECFLLALIYIDR------------------------------------------------ 32

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063864654 303 pqsgspnphepstpteappsppmeatLAEAGNFFVVDSFNIHRLVIAGVTCASKFFSDVFYTNSRYAKasatrsrviptd 382
Cdd:cd20558    33 --------------------------LIATINGFVVTSLNVHRLLITALTLAAKFLDDRYYSNAYYAK------------ 74

                         170       180       190
                  ....*....|....*....|....*....|
gi 1063864654 383 isqVGGLPLVELNHLELQFLILNNFRLSVP 412
Cdd:cd20558    75 ---VGGVSVSELNKLELEFLFLLDFDLHVS 101
 
Name Accession Description Interval E-value
Cyclin pfam08613
Cyclin; This family includes many different cyclin proteins. Members include the G1/S-specific ...
 170-409 1.00e-36

Cyclin; This family includes many different cyclin proteins. Members include the G1/S-specific cyclin pas1, and the phosphate system cyclin PHO80/PHO85.


Pssm-ID: 400780  Cd Length: 149  Bit Score: 132.19  E-value: 1.00e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063864654 170 TDIIEMVAGLLTKITHTNDrnhdhiNRPIPLPEDQANMSPQM--TSVLAFHGKNVPSITILSYLSRIHKYCPTTYEVFLS 247
Cdd:pfam08613   1 DKLIQMISGELDRLIANND------GTATASSDAQSPLEPSQlqSPELSFYSKAVPAISIGAYLSRIQKFCPSSPAVLLS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063864654 248 LLVYFDRMtevvnknllmqsqsQRRdpnaseaslpsmttgestlsleghdpaptppqsgspnphepstpteappsppmea 327
Cdd:pfam08613  75 ALIYLDRL--------------VKR------------------------------------------------------- 85

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063864654 328 TLAEAgnfFVVDSFNIHRLVIAGVTCASKFFSDVFYTNSRYAKasatrsrviptdisqVGGLPLVELNHLELQFLILNNF 407
Cdd:pfam08613  86 CDSEA---FVVTSANAHRLLITAVTVATKFLSDGFYSNSRFAK---------------VGGISLHELNHLEIDFLFLVDF 147


                  ..
gi 1063864654 408 RL 409
Cdd:pfam08613 148 DL 149
CYCLIN_ScPCL7-like cd20558
cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins; ...
 223-412 7.32e-36

cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins; ScPCL7, also called PHO85-associated protein 1, is a cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL6, ScPCL7 controls glycogen phosphorylase and glycogen synthase activities in response to nutrient availablility. This family also includes Schizosaccharomyces pombe PHO85 cyclin-like protein Psl1 (SpPsl1) and Arabidopsis thaliana PHO80-like proteins, P-type cyclins (CYCPs). SpPsl1 is the cyclin partner of the CDK pef1 (PHO85 homolog). CYCPs may be involved in cell division, cell differentiation, and the nutritional status of the cell in Arabidopsis thaliana. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410261  Cd Length: 101  Bit Score: 128.06  E-value: 7.32e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063864654 223 PSITILSYLSRIHKYCPTTYEVFLSLLVYFDRmtevvnknllmqsqsqrrdpnaseaslpsmttgestlsleghdpaptp 302
Cdd:cd20558     1 PSISILDYLERIVKYCPCSPECFLLALIYIDR------------------------------------------------ 32

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063864654 303 pqsgspnphepstpteappsppmeatLAEAGNFFVVDSFNIHRLVIAGVTCASKFFSDVFYTNSRYAKasatrsrviptd 382
Cdd:cd20558    33 --------------------------LIATINGFVVTSLNVHRLLITALTLAAKFLDDRYYSNAYYAK------------ 74

                         170       180       190
                  ....*....|....*....|....*....|
gi 1063864654 383 isqVGGLPLVELNHLELQFLILNNFRLSVP 412
Cdd:cd20558    75 ---VGGVSVSELNKLELEFLFLLDFDLHVS 101
CYCLIN_AtCycU-like cd20604
cyclin box found in Arabidopsis thaliana U-type cyclins (CycUs) and similar proteins; CycUs ...
 213-419 1.55e-20

cyclin box found in Arabidopsis thaliana U-type cyclins (CycUs) and similar proteins; CycUs interact with cyclin-dependent kinase A-1 (CDKA-1) to trigger its kinase activity. CycUs contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410307  Cd Length: 126  Bit Score: 87.06  E-value: 1.55e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063864654 213 SVLAFHGKNVPSITILSYLSRIHKYCPTTYEVFLSLLVYFDRMTevvnknllmqsQSQRrdpnaseaslpsmttgestls 292
Cdd:cd20604     1 KVTVFHGVRAPSISIASYLERIFKYTNCSPSCFVVAYVYIDRFI-----------HKQP--------------------- 48

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063864654 293 leghdpaptppqsgspnphepstpteappsppmeatlaeagnFFVVDSFNIHRLVIAGVTCASKFFSDVFYTNSRYAKas 372
Cdd:cd20604    49 ------------------------------------------GLPISSLNVHRLLITSVMVAAKFLDDLYYNNAYYAK-- 84

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1063864654 373 atrsrviptdisqVGGLPLVELNHLELQFLILNNFRLSVPVEELEAY 419
Cdd:cd20604    85 -------------VGGVSTEELNRLELEFLFLLDFKLNVTVSVFESY 118
CYCLIN_ScPCL1-like cd20557
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar ...
 340-402 2.21e-05

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins; The family includes a group of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase, such as Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2, PCL9 and their vertebrate counterparts, cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1). PCL1 (also called PHO85 cyclin-1, or cyclin HCS26) and PCL2 (also called PHO85 cyclin-1, or cyclin HCS26 homolog) are G1/S-specific cyclin partners of the cyclin-dependent kinase (CDK) PHO85. They are essential for the control of the cell cycle at the G1/S (start) transition. The PCL1-PHO85 cyclin-CDK holoenzyme is involved in phosphorylation of the CDK inhibitor (CKI) SIC1, which is required for its ubiquitination and degradation, releasing repression of b-type cyclins and promoting exit from mitosis. Together with cyclin PCL2, it positively controls degradation of sphingoid long chain base kinase LCB4. PCL1-PHO85 also phosphorylates HMS1, NCP1 and NPA3, which may all have a role in mitotic exit. PCL2-PHO85 also phosphorylates RVS167, linking cyclin-CDK activity with organization of the actin cytoskeleton. PCL9 is an M/G1-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. It may have a role in bud site selection in the G1 phase. The family also includes cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1) and similar proteins. Their biological functions remain unclear. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410260  Cd Length: 94  Bit Score: 43.03  E-value: 2.21e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063864654 340 SFNIHRLVIAGVTCASKFFSDVFYTNSRYAKASatrsrviptdisqvgGLPLVELNHLELQFL 402
Cdd:cd20557    42 EGSPYRLFLVALMLASKYLDDESYSNKSWAEIS---------------GLPVRELNAMEREFL 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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