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Conserved domains on  [gi|1063721657|ref|NP_001328453|]
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Nuclear transport factor 2 (NTF2) family protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SnoaL_3 pfam13474
SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.
 108-221 3.27e-24

SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.


:

Pssm-ID: 433238  Cd Length: 121  Bit Score: 93.18  E-value: 3.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063721657 108 IISVNTEFFTIIRDRALQAMARLWlnSDYVKCIH-ASGELFSGYNEVIQSWQLCFNWEQGFDFQVHTVRTRILTDMAWVT 186
Cdd:pfam13474   1 VNALNDAWYEAAAEGDFDALFALW--SDDISCIGtGAGELWRGREEFRRSWKQDFAQAQGWQFELLDRRVTVLGDVAWVT 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1063721657 187 MKAYLNVD------GGPFLITNVFEFHNGRWHMVHHHSSVM 221
Cdd:pfam13474  79 ELLNITAAadgteaYGPFRLTGVLRRTDGGWKIVHHHLSVP 119
F-box_FBXL4 cd22117
F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also ...
 38-83 3.01e-18

F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438889  Cd Length: 47  Bit Score: 75.35  E-value: 3.01e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1063721657  38 EQLVP-EITTHALSYLDYPSLCRLSMTNSLMRKAANDDNAWKALYHK 83
Cdd:cd22117     1 FDLLPyELIQLILSYLDLPSLCRLSQTCKLFRKHCYDPLLWKELNLQ 47
 
Name Accession Description Interval E-value
SnoaL_3 pfam13474
SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.
 108-221 3.27e-24

SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.


Pssm-ID: 433238  Cd Length: 121  Bit Score: 93.18  E-value: 3.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063721657 108 IISVNTEFFTIIRDRALQAMARLWlnSDYVKCIH-ASGELFSGYNEVIQSWQLCFNWEQGFDFQVHTVRTRILTDMAWVT 186
Cdd:pfam13474   1 VNALNDAWYEAAAEGDFDALFALW--SDDISCIGtGAGELWRGREEFRRSWKQDFAQAQGWQFELLDRRVTVLGDVAWVT 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1063721657 187 MKAYLNVD------GGPFLITNVFEFHNGRWHMVHHHSSVM 221
Cdd:pfam13474  79 ELLNITAAadgteaYGPFRLTGVLRRTDGGWKIVHHHLSVP 119
F-box_FBXL4 cd22117
F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also ...
 38-83 3.01e-18

F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438889  Cd Length: 47  Bit Score: 75.35  E-value: 3.01e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1063721657  38 EQLVP-EITTHALSYLDYPSLCRLSMTNSLMRKAANDDNAWKALYHK 83
Cdd:cd22117     1 FDLLPyELIQLILSYLDLPSLCRLSQTCKLFRKHCYDPLLWKELNLQ 47
YybH COG4319
Ketosteroid isomerase homolog YybH [General function prediction only];
103-219 1.50e-11

Ketosteroid isomerase homolog YybH [General function prediction only];


Pssm-ID: 443460 [Multi-domain]  Cd Length: 131  Bit Score: 59.77  E-value: 1.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063721657 103 ATTRAIISVNTEFFTIIRDRALQAMARLWlnSDYVKCIHASGELFSGYNEVIQSWQLCFNWEQGFDFQVHTVRTRILTDM 182
Cdd:COG4319     6 EDEAAIRALLAAFAEAFNAGDADALAALY--AEDAVFFDPGGPPVRGREAIRAAWAAAFAAGPRVTFEVEDVRVLVSGDV 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1063721657 183 AWVTMKAYLNV---DGGPFLI----TNVFEFH-NGRWHMVHHHSS 219
Cdd:COG4319    84 AVVTGRWRLTGtdpDGEPVELagryTLVFRKQaDGRWKIVHDHAS 128
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 37-81 3.95e-05

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 39.77  E-value: 3.95e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1063721657  37 MEQLVPEITTHALSYLDYPSLCRLSMTNSLMRKAANDDNAWKALY 81
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
 
Name Accession Description Interval E-value
SnoaL_3 pfam13474
SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.
 108-221 3.27e-24

SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.


Pssm-ID: 433238  Cd Length: 121  Bit Score: 93.18  E-value: 3.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063721657 108 IISVNTEFFTIIRDRALQAMARLWlnSDYVKCIH-ASGELFSGYNEVIQSWQLCFNWEQGFDFQVHTVRTRILTDMAWVT 186
Cdd:pfam13474   1 VNALNDAWYEAAAEGDFDALFALW--SDDISCIGtGAGELWRGREEFRRSWKQDFAQAQGWQFELLDRRVTVLGDVAWVT 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1063721657 187 MKAYLNVD------GGPFLITNVFEFHNGRWHMVHHHSSVM 221
Cdd:pfam13474  79 ELLNITAAadgteaYGPFRLTGVLRRTDGGWKIVHHHLSVP 119
F-box_FBXL4 cd22117
F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also ...
 38-83 3.01e-18

F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438889  Cd Length: 47  Bit Score: 75.35  E-value: 3.01e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1063721657  38 EQLVP-EITTHALSYLDYPSLCRLSMTNSLMRKAANDDNAWKALYHK 83
Cdd:cd22117     1 FDLLPyELIQLILSYLDLPSLCRLSQTCKLFRKHCYDPLLWKELNLQ 47
YybH COG4319
Ketosteroid isomerase homolog YybH [General function prediction only];
103-219 1.50e-11

Ketosteroid isomerase homolog YybH [General function prediction only];


Pssm-ID: 443460 [Multi-domain]  Cd Length: 131  Bit Score: 59.77  E-value: 1.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063721657 103 ATTRAIISVNTEFFTIIRDRALQAMARLWlnSDYVKCIHASGELFSGYNEVIQSWQLCFNWEQGFDFQVHTVRTRILTDM 182
Cdd:COG4319     6 EDEAAIRALLAAFAEAFNAGDADALAALY--AEDAVFFDPGGPPVRGREAIRAAWAAAFAAGPRVTFEVEDVRVLVSGDV 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1063721657 183 AWVTMKAYLNV---DGGPFLI----TNVFEFH-NGRWHMVHHHSS 219
Cdd:COG4319    84 AVVTGRWRLTGtdpDGEPVELagryTLVFRKQaDGRWKIVHDHAS 128
F-box_FBXO15 cd22093
F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called ...
 37-81 4.44e-07

F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438865  Cd Length: 46  Bit Score: 45.32  E-value: 4.44e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1063721657  37 MEQLVPEITTHALSYLDYPSLCRLSMTNSLMRKAANDDNAWKALY 81
Cdd:cd22093     1 IERLPSEILLKILSYLDASSLLCISCVNKLFYQLANDNALWRKLY 45
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
 37-80 2.87e-06

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 43.07  E-value: 2.87e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1063721657  37 MEQLVPEITTHALSYLDYPSLCRLSMTNSLMRKAANDDNAWKAL 80
Cdd:cd22147     2 LSALPVELSLKILSYLDAKSLCRAAQVSKKWRNLADDDELWKRM 45
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 37-81 3.95e-05

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 39.77  E-value: 3.95e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1063721657  37 MEQLVPEITTHALSYLDYPSLCRLSMTNSLMRKAANDDNAWKALY 81
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
F-box_FBXO36 cd22106
F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called ...
 38-82 4.76e-05

F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called FBX36, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438878  Cd Length: 46  Bit Score: 39.87  E-value: 4.76e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1063721657  38 EQLVPEITTHALSYLDYPSLCRLSMTNSLMRKAANDDNAWKALYH 82
Cdd:cd22106     2 VRLPDKLLLYIISYLDLEDIARLSQTSKRFKKLCNSDELWEKIYM 46
F-box_FBXO48 cd22113
F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called ...
 38-78 1.76e-04

F-box domain found in F-box only protein 48 (FBXO48) and similar proteins; FBXO48, also called FBX48, is one of the paralogs of the F-box only protein 7 (FBXO7), which is the causative gene for PARK15 (also known as Parkinsonian-pyramidal disease, PPD). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438885  Cd Length: 46  Bit Score: 38.07  E-value: 1.76e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1063721657  38 EQLVPEITTHALSYLDYPSLCRLSMT----NSLMRkaaNDDNAWK 78
Cdd:cd22113     2 ELLPPEMSLRIFSQLDVQSLCRASQTcktwNDLIE---NSDYLWR 43
F-box_FBXO7 cd22087
F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called ...
 40-81 1.84e-04

F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called FBX7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes BIRC2 and DLGAP5. FBXO7 plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. It promotes MFN1 ubiquitination. FBXO7 acts as a cell cycle regulator by enhancing cyclin D/cyclin-dependent kinase 6 (Cdk6) complex formation and stabilizing levels of p27, a cyclin-dependent kinase inhibitor. Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism called parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438859  Cd Length: 45  Bit Score: 38.05  E-value: 1.84e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1063721657  40 LVPEITTHALSYLDYPSLCRLSMTNSLMRKAANDDNAWKALY 81
Cdd:cd22087     4 LPPEIKLRILSLLDVRSLLSLSQVCRDLNSATNDQLLWRFLL 45
F-box_FBXO3 cd22084
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ...
 40-83 3.71e-04

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438856  Cd Length: 49  Bit Score: 37.24  E-value: 3.71e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1063721657  40 LVPEITTHALSYLDYPSLCRLSMTNSLMRKAANDDNAWKALYHK 83
Cdd:cd22084     4 LPSDPLLNILSFLDYRDLISCSQVCRRLNQLCSHDPLWKRLCKK 47
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 42-72 3.99e-04

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 36.65  E-value: 3.99e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1063721657  42 PEITTHALSYLDYPSLCRLSMTNSLMRKAAN 72
Cdd:cd09917     5 DEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 37-78 2.17e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 34.82  E-value: 2.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1063721657  37 MEQLVPEITTHALSYLDYPSLCRLSMTNSLMRKAANDDNAWK 78
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42
CaMKIID COG4875
Protein kinase association domain CaMKII_AD, NTF2-like superfamily [Posttranslational ...
 201-221 3.68e-03

Protein kinase association domain CaMKII_AD, NTF2-like superfamily [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443903  Cd Length: 156  Bit Score: 36.91  E-value: 3.68e-03
                          10        20
                  ....*....|....*....|.
gi 1063721657 201 TNVFEFHNGRWHMVHHHSSVM 221
Cdd:COG4875   134 TFTYEKQGGQWLITSHHSSAM 154
F-box_4 pfam15966
F-box;
43-68 9.13e-03

F-box;


Pssm-ID: 464958  Cd Length: 116  Bit Score: 34.96  E-value: 9.13e-03
                          10        20
                  ....*....|....*....|....*.
gi 1063721657  43 EITTHALSYLDYPSLCRLSMTNSLMR 68
Cdd:pfam15966  11 EVLQHIASFLDSFSLSQLSLVSRLMR 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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