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Conserved domains on  [gi|1063695625|ref|NP_001320868|]
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P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NOG cd01897
Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in ...
 238-416 9.42e-75

Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in eukaryotes ranging from trypanosomes to humans. NOG1 is functionally linked to ribosome biogenesis and found in association with the nuclear pore complexes and identified in many preribosomal complexes. Thus, defects in NOG1 can lead to defects in 60S biogenesis. The S. cerevisiae NOG1 gene is essential for cell viability, and mutations in the predicted G motifs abrogate function. It is a member of the ODN family of GTP-binding proteins that also includes the bacterial Obg and DRG proteins.


:

Pssm-ID: 206684 [Multi-domain]  Cd Length: 167  Bit Score: 230.91  E-value: 9.42e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 238 PTLCLVGAPNVGKSSLVRILSTGKPEICNYPFTTRGILMGHIVLNYQRFQVTDTPGLLRRCDEDRNNLEKLTLAVLTHLP 317
Cdd:cd01897     1 RTLVIAGYPNVGKSSLVNKLTRAKPEVAPYPFTTKSLFVGHFDYKYLRWQVIDTPGILDRPLEERNTIEMQAITALAHLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 318 TAVLYVHDLTGECGTSPSDQFQIYKEMKERFkDYLWIDAVSKCDLLGGSPVMyakedrssddaEIIKYRERGPDESIHVS 397
Cdd:cd01897    81 AAVLFFIDPSETCGYSIEEQLSLFKEIKPLF-NKPVIVVLNKIDLLTEEDLS-----------EIEKELEKEGEEVIKIS 148

                         170
                  ....*....|....*....
gi 1063695625 398 VKTEQGLNELKNKVKEVLS 416
Cdd:cd01897   149 TLTEEGVDELKNKACELLL 167
NOG1_N super family cl39324
NOG1 N-terminal helical domain; This domain is found at the N-terminus of NOG1 GTPase proteins.
 76-234 3.23e-49

NOG1 N-terminal helical domain; This domain is found at the N-terminus of NOG1 GTPase proteins.


The actual alignment was detected with superfamily member pfam17835:

Pssm-ID: 436080  Cd Length: 160  Bit Score: 164.88  E-value: 3.23e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625  76 FQKLPMVMPSIDLYASALRKSKRVQPTKGIA-NIAKRERNRGAKQLDAFMKELALPLKGYMESFPRKKLLHPYERSLIDL 154
Cdd:pfam17835   1 FEKIPIVPTSEELIDSALRRAKRIGPTTKKKgNEINRLRNRYARQLDTAMKTLSDKLSTIVEKFPNLDELHPFYRELLDA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 155 TLGDGKYEEVLGKVDVLRKKVQSVGKEHASLCAKALSKKEAEERLSEGVEKLELVFQQQGGAVDDLLTIAKVLRAMPVVD 234
Cdd:pfam17835  81 VAGKDEYKKSLGQVNTARKIIRKIGKEYANLLKKSGDKKEAEELRREAFGRVASVLRKIGPCLDFLEDIAKKLRKLPVID 160
 
Name Accession Description Interval E-value
NOG cd01897
Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in ...
 238-416 9.42e-75

Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in eukaryotes ranging from trypanosomes to humans. NOG1 is functionally linked to ribosome biogenesis and found in association with the nuclear pore complexes and identified in many preribosomal complexes. Thus, defects in NOG1 can lead to defects in 60S biogenesis. The S. cerevisiae NOG1 gene is essential for cell viability, and mutations in the predicted G motifs abrogate function. It is a member of the ODN family of GTP-binding proteins that also includes the bacterial Obg and DRG proteins.


Pssm-ID: 206684 [Multi-domain]  Cd Length: 167  Bit Score: 230.91  E-value: 9.42e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 238 PTLCLVGAPNVGKSSLVRILSTGKPEICNYPFTTRGILMGHIVLNYQRFQVTDTPGLLRRCDEDRNNLEKLTLAVLTHLP 317
Cdd:cd01897     1 RTLVIAGYPNVGKSSLVNKLTRAKPEVAPYPFTTKSLFVGHFDYKYLRWQVIDTPGILDRPLEERNTIEMQAITALAHLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 318 TAVLYVHDLTGECGTSPSDQFQIYKEMKERFkDYLWIDAVSKCDLLGGSPVMyakedrssddaEIIKYRERGPDESIHVS 397
Cdd:cd01897    81 AAVLFFIDPSETCGYSIEEQLSLFKEIKPLF-NKPVIVVLNKIDLLTEEDLS-----------EIEKELEKEGEEVIKIS 148

                         170
                  ....*....|....*....
gi 1063695625 398 VKTEQGLNELKNKVKEVLS 416
Cdd:cd01897   149 TLTEEGVDELKNKACELLL 167
Nog1 COG1084
GTP-binding protein, GTP1/Obg family [General function prediction only];
76-421 8.62e-67

GTP-binding protein, GTP1/Obg family [General function prediction only];


Pssm-ID: 440701 [Multi-domain]  Cd Length: 330  Bit Score: 216.24  E-value: 8.62e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625  76 FQKLPMVMPSIDLYASALRKSKRVQPTK-GIANIAKRERNRgakqLDAFMKELALPLKGYMESFPRKKLLHPYERSLIDL 154
Cdd:COG1084     3 FEKIPTVPTADELIDKAFRRAARAGRAKrGLEKGREAEESR----LRTAANILSDNLENIVRKFPDFDELHPFYRELADI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 155 TLGDGKYEEVLGKVDVLRKKVQSVGKEHASLCAKALSK------KEAEERLSEGVEKLElvfqqqggavDDLLTIAKV-- 226
Cdd:COG1084    79 LVGVDELKKSLSAVSWASRKIKEISREYIRKIRRADSDearklrKEAFGRIASVVRRID----------DDLLFLNEArn 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 227 -LRAMPVVDLEMPTLCLVGAPNVGKSSLVRILSTGKPEICNYPFTTRGILMGHIVLNYQRFQVTDTPGLLRRCDEDRNNL 305
Cdd:COG1084   149 kLRKLPDIDPDLPTIVVAGYPNVGKSSLVSKVTSAKPEIASYPFTTKGIIVGHFERGHGRYQVIDTPGLLDRPLSERNEI 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 306 EKLTLAVLTHLPTAVLYVHDLTGECGTSPSDQFQIYKEMKERFKDYLwIDAVSKCDLlggspvmyakedrsSDDAEIIKY 385
Cdd:COG1084   229 ERQAILALKHLADVILFLFDPSETCGYSLEEQLNLLEEIRSLFDVPV-IVVINKIDL--------------SDEEELKEA 293

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1063695625 386 RERGPdesIHVSVKTEQGLNELKNKVKEVLSSEMEK 421
Cdd:COG1084   294 EEEAD---IKISALTGEGVDELLDELIEALEEEPEL 326
NOG1_N pfam17835
NOG1 N-terminal helical domain; This domain is found at the N-terminus of NOG1 GTPase proteins.
 76-234 3.23e-49

NOG1 N-terminal helical domain; This domain is found at the N-terminus of NOG1 GTPase proteins.


Pssm-ID: 436080  Cd Length: 160  Bit Score: 164.88  E-value: 3.23e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625  76 FQKLPMVMPSIDLYASALRKSKRVQPTKGIA-NIAKRERNRGAKQLDAFMKELALPLKGYMESFPRKKLLHPYERSLIDL 154
Cdd:pfam17835   1 FEKIPIVPTSEELIDSALRRAKRIGPTTKKKgNEINRLRNRYARQLDTAMKTLSDKLSTIVEKFPNLDELHPFYRELLDA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 155 TLGDGKYEEVLGKVDVLRKKVQSVGKEHASLCAKALSKKEAEERLSEGVEKLELVFQQQGGAVDDLLTIAKVLRAMPVVD 234
Cdd:pfam17835  81 VAGKDEYKKSLGQVNTARKIIRKIGKEYANLLKKSGDKKEAEELRREAFGRVASVLRKIGPCLDFLEDIAKKLRKLPVID 160
NOG1 pfam06858
Nucleolar GTP-binding protein 1 (NOG1); This family represents a conserved region of ...
 306-361 5.71e-19

Nucleolar GTP-binding protein 1 (NOG1); This family represents a conserved region of approximately 60 residues in length within nucleolar GTP-binding protein 1 (NOG1). In S. cerevisiae, the NOG1 gene has been shown to be essential for cell viability, suggesting that NOG1 may play an important role in nucleolar functions. Family members include eukaryotic, bacterial and archaeal proteins.


Pssm-ID: 462021 [Multi-domain]  Cd Length: 58  Bit Score: 80.17  E-value: 5.71e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1063695625 306 EKLTLAVLTHLPTAVLYVHDLTGECGTSPSDQFQIYKEMKERFKDYLWIDAVSKCD 361
Cdd:pfam06858   3 EMQAIAALAHLADAVLFVIDPSETCGYSLEEQLSLFEEIKPLFANKPVIVVLNKID 58
Obg_CgtA TIGR02729
Obg family GTPase CgtA; This model describes a univeral, mostly one-gene-per-genome ...
 242-415 2.08e-16

Obg family GTPase CgtA; This model describes a univeral, mostly one-gene-per-genome GTP-binding protein that associates with ribosomal subunits and appears to play a role in ribosomal RNA maturation. This GTPase, related to the nucleolar protein Obg, is designated CgtA in bacteria. Mutations in this gene are pleiotropic, but it appears that effects on cellular functions such as chromosome partition may be secondary to the effect on ribosome structure. Recent work done in Vibrio cholerae shows an essential role in the stringent response, in which RelA-dependent ability to synthesize the alarmone ppGpp is required for deletion of this GTPase to be lethal. [Protein synthesis, Other]


Pssm-ID: 274271 [Multi-domain]  Cd Length: 328  Bit Score: 79.77  E-value: 2.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 242 LVGAPNVGKSSLVRILSTGKPEICNYPFTTR----GILmghIVLNYQRFQVTDTPGLLRRCDEDRNnlekLTLAVLTHLP 317
Cdd:TIGR02729 162 LVGLPNAGKSTLISAVSAAKPKIADYPFTTLvpnlGVV---RVDDGRSFVIADIPGLIEGASEGAG----LGHRFLKHIE 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 318 -TAVLyVH--DLTGECGTSPSDQFQ-IYKEMKeRFKDYL-----WIdAVSKCDLLGgspvmyaKEDRssddAEIIKY-RE 387
Cdd:TIGR02729 235 rTRVL-LHliDISPEDGSDPVEDYEiIRNELK-KYSPELaekprIV-VLNKIDLLD-------EEEL----EELLKElKK 300

                         170       180
                  ....*....|....*....|....*...
gi 1063695625 388 RGPDESIHVSVKTEQGLNELKNKVKEVL 415
Cdd:TIGR02729 301 ELGKPVFPISALTGEGLDELLDALAELL 328
obgE PRK12299
GTPase CgtA; Reviewed
 242-418 6.40e-15

GTPase CgtA; Reviewed


Pssm-ID: 237048 [Multi-domain]  Cd Length: 335  Bit Score: 75.49  E-value: 6.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 242 LVGAPNVGKSSLVRILSTGKPEICNYPFTTrgiLMGHI----VLNYQRFQVTDTPGL--------------LR---RCde 300
Cdd:PRK12299  163 LVGLPNAGKSTLISAVSAAKPKIADYPFTT---LHPNLgvvrVDDYKSFVIADIPGLiegasegaglghrfLKhieRT-- 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 301 drnnlekltlAVLTHLptaVlyvhDLTGEcgtSPSDQFQ-IYKEMkERFKDYL-----WIdAVSKCDLLggspvmyakED 374
Cdd:PRK12299  238 ----------RLLLHL---V----DIEAV---DPVEDYKtIRNEL-EKYSPELadkprIL-VLNKIDLL---------DE 286

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1063695625 375 RSSDDAEIIKYRERGPDESIHVSVKTEQGLNELKNKVKEVLSSE 418
Cdd:PRK12299  287 EEEREKRAALELAALGGPVFLISAVTGEGLDELLRALWELLEEA 330
 
Name Accession Description Interval E-value
NOG cd01897
Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in ...
 238-416 9.42e-75

Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in eukaryotes ranging from trypanosomes to humans. NOG1 is functionally linked to ribosome biogenesis and found in association with the nuclear pore complexes and identified in many preribosomal complexes. Thus, defects in NOG1 can lead to defects in 60S biogenesis. The S. cerevisiae NOG1 gene is essential for cell viability, and mutations in the predicted G motifs abrogate function. It is a member of the ODN family of GTP-binding proteins that also includes the bacterial Obg and DRG proteins.


Pssm-ID: 206684 [Multi-domain]  Cd Length: 167  Bit Score: 230.91  E-value: 9.42e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 238 PTLCLVGAPNVGKSSLVRILSTGKPEICNYPFTTRGILMGHIVLNYQRFQVTDTPGLLRRCDEDRNNLEKLTLAVLTHLP 317
Cdd:cd01897     1 RTLVIAGYPNVGKSSLVNKLTRAKPEVAPYPFTTKSLFVGHFDYKYLRWQVIDTPGILDRPLEERNTIEMQAITALAHLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 318 TAVLYVHDLTGECGTSPSDQFQIYKEMKERFkDYLWIDAVSKCDLLGGSPVMyakedrssddaEIIKYRERGPDESIHVS 397
Cdd:cd01897    81 AAVLFFIDPSETCGYSIEEQLSLFKEIKPLF-NKPVIVVLNKIDLLTEEDLS-----------EIEKELEKEGEEVIKIS 148

                         170
                  ....*....|....*....
gi 1063695625 398 VKTEQGLNELKNKVKEVLS 416
Cdd:cd01897   149 TLTEEGVDELKNKACELLL 167
Nog1 COG1084
GTP-binding protein, GTP1/Obg family [General function prediction only];
76-421 8.62e-67

GTP-binding protein, GTP1/Obg family [General function prediction only];


Pssm-ID: 440701 [Multi-domain]  Cd Length: 330  Bit Score: 216.24  E-value: 8.62e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625  76 FQKLPMVMPSIDLYASALRKSKRVQPTK-GIANIAKRERNRgakqLDAFMKELALPLKGYMESFPRKKLLHPYERSLIDL 154
Cdd:COG1084     3 FEKIPTVPTADELIDKAFRRAARAGRAKrGLEKGREAEESR----LRTAANILSDNLENIVRKFPDFDELHPFYRELADI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 155 TLGDGKYEEVLGKVDVLRKKVQSVGKEHASLCAKALSK------KEAEERLSEGVEKLElvfqqqggavDDLLTIAKV-- 226
Cdd:COG1084    79 LVGVDELKKSLSAVSWASRKIKEISREYIRKIRRADSDearklrKEAFGRIASVVRRID----------DDLLFLNEArn 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 227 -LRAMPVVDLEMPTLCLVGAPNVGKSSLVRILSTGKPEICNYPFTTRGILMGHIVLNYQRFQVTDTPGLLRRCDEDRNNL 305
Cdd:COG1084   149 kLRKLPDIDPDLPTIVVAGYPNVGKSSLVSKVTSAKPEIASYPFTTKGIIVGHFERGHGRYQVIDTPGLLDRPLSERNEI 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 306 EKLTLAVLTHLPTAVLYVHDLTGECGTSPSDQFQIYKEMKERFKDYLwIDAVSKCDLlggspvmyakedrsSDDAEIIKY 385
Cdd:COG1084   229 ERQAILALKHLADVILFLFDPSETCGYSLEEQLNLLEEIRSLFDVPV-IVVINKIDL--------------SDEEELKEA 293

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1063695625 386 RERGPdesIHVSVKTEQGLNELKNKVKEVLSSEMEK 421
Cdd:COG1084   294 EEEAD---IKISALTGEGVDELLDELIEALEEEPEL 326
NOG1_N pfam17835
NOG1 N-terminal helical domain; This domain is found at the N-terminus of NOG1 GTPase proteins.
 76-234 3.23e-49

NOG1 N-terminal helical domain; This domain is found at the N-terminus of NOG1 GTPase proteins.


Pssm-ID: 436080  Cd Length: 160  Bit Score: 164.88  E-value: 3.23e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625  76 FQKLPMVMPSIDLYASALRKSKRVQPTKGIA-NIAKRERNRGAKQLDAFMKELALPLKGYMESFPRKKLLHPYERSLIDL 154
Cdd:pfam17835   1 FEKIPIVPTSEELIDSALRRAKRIGPTTKKKgNEINRLRNRYARQLDTAMKTLSDKLSTIVEKFPNLDELHPFYRELLDA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 155 TLGDGKYEEVLGKVDVLRKKVQSVGKEHASLCAKALSKKEAEERLSEGVEKLELVFQQQGGAVDDLLTIAKVLRAMPVVD 234
Cdd:pfam17835  81 VAGKDEYKKSLGQVNTARKIIRKIGKEYANLLKKSGDKKEAEELRREAFGRVASVLRKIGPCLDFLEDIAKKLRKLPVID 160
Obg_like cd01881
Obg-like family of GTPases consist of five subfamilies: Obg, DRG, YyaF/YchF, Ygr210, and NOG1; ...
 242-415 1.06e-24

Obg-like family of GTPases consist of five subfamilies: Obg, DRG, YyaF/YchF, Ygr210, and NOG1; The Obg-like subfamily consists of five well-delimited, ancient subfamilies, namely Obg, DRG, YyaF/YchF, Ygr210, and NOG1. Four of these groups (Obg, DRG, YyaF/YchF, and Ygr210) are characterized by a distinct glycine-rich motif immediately following the Walker B motif (G3 box). Obg/CgtA is an essential gene that is involved in the initiation of sporulation and DNA replication in the bacteria Caulobacter and Bacillus, but its exact molecular role is unknown. Furthermore, several OBG family members possess a C-terminal RNA-binding domain, the TGS domain, which is also present in threonyl-tRNA synthetase and in bacterial guanosine polyphosphatase SpoT. Nog1 is a nucleolar protein that might function in ribosome assembly. The DRG and Nog1 subfamilies are ubiquitous in archaea and eukaryotes, the Ygr210 subfamily is present in archaea and fungi, and the Obg and YyaF/YchF subfamilies are ubiquitous in bacteria and eukaryotes. The Obg/Nog1 and DRG subfamilies appear to form one major branch of the Obg family and the Ygr210 and YchF subfamilies form another branch. No GEFs, GAPs, or GDIs for Obg have been identified.


Pssm-ID: 206668 [Multi-domain]  Cd Length: 167  Bit Score: 99.78  E-value: 1.06e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 242 LVGAPNVGKSSLVRILSTGKPEICNYPFTTRGILMGHI-VLNYQRFQVTDTPGLLRRCDEDRNNLEKLTlaVLTHLPTAV 320
Cdd:cd01881     2 LVGLPNVGKSTLLSALTSAKVEIASYPFTTLEPNVGVFeFGDGVDIQIIDLPGLLDGASEGRGLGEQIL--AHLYRSDLI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 321 LYVHDLTGECGTSPSDQ----FQIYKEMKERFKDYLWIDAVSKCDLLGGSPVMYAKEDRSSDDAEIIKyrergpdesihV 396
Cdd:cd01881    80 LHVIDASEDCVGDPLEDqktlNEEVSGSFLFLKNKPEMIVANKIDMASENNLKRLKLDKLKRGIPVVP-----------T 148

                         170
                  ....*....|....*....
gi 1063695625 397 SVKTEQGLNELKNKVKEVL 415
Cdd:cd01881   149 SALTRLGLDRVIRTIRKLL 167
Obg cd01898
Obg GTPase; The Obg nucleotide binding protein subfamily has been implicated in stress ...
 242-415 1.93e-19

Obg GTPase; The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins conserved from bacteria to humans. The E. coli homolog, ObgE is believed to function in ribosomal biogenesis. Members of the subfamily contain two equally and highly conserved domains, a C-terminal GTP binding domain and an N-terminal glycine-rich domain.


Pssm-ID: 206685 [Multi-domain]  Cd Length: 170  Bit Score: 85.17  E-value: 1.93e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 242 LVGAPNVGKSSLVRILSTGKPEICNYPFTTR----GILMghiVLNYQRFQVTDTPGLLRRCDEDRNnlekLTLAVLTHLP 317
Cdd:cd01898     5 LVGLPNAGKSTLLSAISNAKPKIADYPFTTLvpnlGVVR---VDDGRSFVIADIPGLIEGASEGKG----LGHRFLRHIE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 318 -TAVL-YVHDLTGEcgTSPSDQFQIYKEMKERFKDYL-----WIdAVSKCDLLggspvmyAKEDRSSDDAEIIKyrERGP 390
Cdd:cd01898    78 rTRVLlHVIDLSGE--DDPVEDYETIRNELEAYNPGLaekprIV-VLNKIDLL-------DAEERFEKLKELLK--ELKG 145

                         170       180
                  ....*....|....*....|....*
gi 1063695625 391 DESIHVSVKTEQGLNELKNKVKEVL 415
Cdd:cd01898   146 KKVFPISALTGEGLDELLKKLAKLL 170
NOG1 pfam06858
Nucleolar GTP-binding protein 1 (NOG1); This family represents a conserved region of ...
 306-361 5.71e-19

Nucleolar GTP-binding protein 1 (NOG1); This family represents a conserved region of approximately 60 residues in length within nucleolar GTP-binding protein 1 (NOG1). In S. cerevisiae, the NOG1 gene has been shown to be essential for cell viability, suggesting that NOG1 may play an important role in nucleolar functions. Family members include eukaryotic, bacterial and archaeal proteins.


Pssm-ID: 462021 [Multi-domain]  Cd Length: 58  Bit Score: 80.17  E-value: 5.71e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1063695625 306 EKLTLAVLTHLPTAVLYVHDLTGECGTSPSDQFQIYKEMKERFKDYLWIDAVSKCD 361
Cdd:pfam06858   3 EMQAIAALAHLADAVLFVIDPSETCGYSLEEQLSLFEEIKPLFANKPVIVVLNKID 58
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 239-325 1.53e-16

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 75.35  E-value: 1.53e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 239 TLCLVGAPNVGKSSLVRILSTGKPEICNYPFTTRGILMGHIVLNYQRFQVTDTPGLLRRCDEDrnnlEKLTLAVLTHLPT 318
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALTGAKAIVSDYPGTTRDPNEGRLELKGKQIILVDTPGLIEGASEG----EGLGRAFLAIIEA 76


                  ....*...
gi 1063695625 319 -AVLYVHD 325
Cdd:pfam01926  77 dLILFVVD 84
Obg_CgtA TIGR02729
Obg family GTPase CgtA; This model describes a univeral, mostly one-gene-per-genome ...
 242-415 2.08e-16

Obg family GTPase CgtA; This model describes a univeral, mostly one-gene-per-genome GTP-binding protein that associates with ribosomal subunits and appears to play a role in ribosomal RNA maturation. This GTPase, related to the nucleolar protein Obg, is designated CgtA in bacteria. Mutations in this gene are pleiotropic, but it appears that effects on cellular functions such as chromosome partition may be secondary to the effect on ribosome structure. Recent work done in Vibrio cholerae shows an essential role in the stringent response, in which RelA-dependent ability to synthesize the alarmone ppGpp is required for deletion of this GTPase to be lethal. [Protein synthesis, Other]


Pssm-ID: 274271 [Multi-domain]  Cd Length: 328  Bit Score: 79.77  E-value: 2.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 242 LVGAPNVGKSSLVRILSTGKPEICNYPFTTR----GILmghIVLNYQRFQVTDTPGLLRRCDEDRNnlekLTLAVLTHLP 317
Cdd:TIGR02729 162 LVGLPNAGKSTLISAVSAAKPKIADYPFTTLvpnlGVV---RVDDGRSFVIADIPGLIEGASEGAG----LGHRFLKHIE 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 318 -TAVLyVH--DLTGECGTSPSDQFQ-IYKEMKeRFKDYL-----WIdAVSKCDLLGgspvmyaKEDRssddAEIIKY-RE 387
Cdd:TIGR02729 235 rTRVL-LHliDISPEDGSDPVEDYEiIRNELK-KYSPELaekprIV-VLNKIDLLD-------EEEL----EELLKElKK 300

                         170       180
                  ....*....|....*....|....*...
gi 1063695625 388 RGPDESIHVSVKTEQGLNELKNKVKEVL 415
Cdd:TIGR02729 301 ELGKPVFPISALTGEGLDELLDALAELL 328
Obg COG0536
GTPase involved in cell partioning and DNA repair [Cell cycle control, cell division, ...
 242-415 1.86e-15

GTPase involved in cell partioning and DNA repair [Cell cycle control, cell division, chromosome partitioning, Replication, recombination, and repair];


Pssm-ID: 440302 [Multi-domain]  Cd Length: 343  Bit Score: 76.94  E-value: 1.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 242 LVGAPNVGKSSLVRILSTGKPEICNYPFTTR----GILMghiVLNYQRFQVTDTPGL--------------LR---RCde 300
Cdd:COG0536   162 LVGLPNAGKSTLLSAVSAAKPKIADYPFTTLvpnlGVVR---VGDGRSFVIADIPGLiegasegaglghrfLRhieRT-- 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 301 drnnlekltlAVLTHLptaVlyvhDLTGECGTSPSDQFQ-IYKEMkERFKDYL-----WIdAVSKCDLLGGspvmyakED 374
Cdd:COG0536   237 ----------RVLLHV---V----DAAPLDGRDPVEDYEiIRNEL-EAYSPELaekprIV-VLNKIDLLDA-------EE 290

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1063695625 375 RssddAEIIKYRERGPDESIHVSVKTEQGLNELKNKVKEVL 415
Cdd:COG0536   291 L----EELKAELEKLGGPVFPISAVTGEGLDELLYALAELL 327
Era_like cd00880
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ...
 242-415 4.50e-15

E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.


Pssm-ID: 206646 [Multi-domain]  Cd Length: 161  Bit Score: 72.28  E-value: 4.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 242 LVGAPNVGKSSLVRILsTGKP--EICNYPFTTRGILMGHIVLN-YQRFQVTDTPGLLrRCDEDRNNLEKLTLAVLTHLpT 318
Cdd:cd00880     2 IFGRPNVGKSSLLNAL-LGQNvgIVSPIPGTTRDPVRKEWELLpLGPVVLIDTPGLD-EEGGLGRERVEEARQVADRA-D 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 319 AVLYVHDLTGecgtSPSDQFQIYKEMKERFKDYLWIdaVSKCDLLGGSPVMYAKEDRssddaeiiKYRERGPDESIHVSV 398
Cdd:cd00880    79 LVLLVVDSDL----TPVEEEAKLGLLRERGKPVLLV--LNKIDLVPESEEEELLRER--------KLELLPDLPVIAVSA 144

                         170
                  ....*....|....*..
gi 1063695625 399 KTEQGLNELKNKVKEVL 415
Cdd:cd00880   145 LPGEGIDELRKKIAELL 161
obgE PRK12299
GTPase CgtA; Reviewed
 242-418 6.40e-15

GTPase CgtA; Reviewed


Pssm-ID: 237048 [Multi-domain]  Cd Length: 335  Bit Score: 75.49  E-value: 6.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 242 LVGAPNVGKSSLVRILSTGKPEICNYPFTTrgiLMGHI----VLNYQRFQVTDTPGL--------------LR---RCde 300
Cdd:PRK12299  163 LVGLPNAGKSTLISAVSAAKPKIADYPFTT---LHPNLgvvrVDDYKSFVIADIPGLiegasegaglghrfLKhieRT-- 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 301 drnnlekltlAVLTHLptaVlyvhDLTGEcgtSPSDQFQ-IYKEMkERFKDYL-----WIdAVSKCDLLggspvmyakED 374
Cdd:PRK12299  238 ----------RLLLHL---V----DIEAV---DPVEDYKtIRNEL-EKYSPELadkprIL-VLNKIDLL---------DE 286

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1063695625 375 RSSDDAEIIKYRERGPDESIHVSVKTEQGLNELKNKVKEVLSSE 418
Cdd:PRK12299  287 EEEREKRAALELAALGGPVFLISAVTGEGLDELLRALWELLEEA 330
obgE PRK12297
GTPase CgtA; Reviewed
 242-432 2.96e-14

GTPase CgtA; Reviewed


Pssm-ID: 237046 [Multi-domain]  Cd Length: 424  Bit Score: 73.98  E-value: 2.96e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 242 LVGAPNVGKSSLVRILSTGKPEICNYPFTTrgilmghIVLN--------YQRFQVTDTPGL--------------LR--- 296
Cdd:PRK12297  163 LVGFPNVGKSTLLSVVSNAKPKIANYHFTT-------LVPNlgvvetddGRSFVMADIPGLiegasegvglghqfLRhie 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 297 RCdedrnnlekltlAVLTHlptavlyVHDLTGECGTSPSDQF-QIYKEMKErFKDYLW----IDAVSKCDLLGgspvmya 371
Cdd:PRK12297  236 RT------------RVIVH-------VIDMSGSEGRDPIEDYeKINKELKL-YNPRLLerpqIVVANKMDLPE------- 288

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063695625 372 kedrssDDAEIIKYRERGPDESIHVSVKTEQGLNELKNKVKEVLSSEMEKIQSGEKTDQSV 432
Cdd:PRK12297  289 ------AEENLEEFKEKLGPKVFPISALTGQGLDELLYAVAELLEETPEFPLEEEEVEEEV 343
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 241-411 2.65e-13

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 67.48  E-value: 2.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 241 CLVGAPNVGKSSLVRILSTGK-PEICNYPFTTRGILMGHIVLNYQRFQVT--DTPGLLRRCDEDRNNLEKLTLAVLthlp 317
Cdd:cd00882     1 VVVGRGGVGKSSLLNALLGGEvGEVSDVPGTTRDPDVYVKELDKGKVKLVlvDTPGLDEFGGLGREELARLLLRGA---- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 318 TAVLYVHDLTGECgTSPSDQFQIYKEMKERFKDYLWIdaVSKCDLLGGSPVmyakedrssDDAEIIKYRERGPDESIH-V 396
Cdd:cd00882    77 DLILLVVDSTDRE-SEEDAKLLILRRLRKEGIPIILV--GNKIDLLEEREV---------EELLRLEELAKILGVPVFeV 144

                         170
                  ....*....|....*
gi 1063695625 397 SVKTEQGLNELKNKV 411
Cdd:cd00882   145 SAKTGEGVDELFEKL 159
trmE cd04164
trmE is a tRNA modification GTPase; TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in ...
 239-415 3.19e-13

trmE is a tRNA modification GTPase; TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase domain that forms a canonical Ras-like fold. It functions a molecular switch GTPase, and apparently uses a conformational change associated with GTP hydrolysis to promote the tRNA modification reaction, in which the conserved cysteine in the C-terminal domain is thought to function as a catalytic residue. In bacteria that are able to survive in extremely low pH conditions, TrmE regulates glutamate-dependent acid resistance.


Pssm-ID: 206727 [Multi-domain]  Cd Length: 159  Bit Score: 67.13  E-value: 3.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 239 TLCLVGAPNVGKSSLVRILStGKP-----EIcnyPFTTRGILMGHIVLNYQRFQVTDTPGlLRrcdEDRNNLEKL----T 309
Cdd:cd04164     5 KVVIAGKPNVGKSSLLNALA-GRDraivsDI---AGTTRDVIEEEIDLGGIPVRLIDTAG-LR---ETEDEIEKIgierA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 310 LAvltHLPTA--VLYVHDLTGecGTSPSDQfQIYKEMKErfKDYLWIdaVSKCDLLGGSPVMYAKEDRssddaeiikyre 387
Cdd:cd04164    77 RE---AIEEAdlVLLVVDASE--GLDEEDL-EILELPAK--KPVIVV--LNKSDLLSDAEGISELNGK------------ 134

                         170       180
                  ....*....|....*....|....*...
gi 1063695625 388 rgpdESIHVSVKTEQGLNELKNKVKEVL 415
Cdd:cd04164   135 ----PIIAISAKTGEGIDELKEALLELA 158
obgE PRK12298
GTPase CgtA; Reviewed
 242-432 4.66e-13

GTPase CgtA; Reviewed


Pssm-ID: 237047 [Multi-domain]  Cd Length: 390  Bit Score: 70.28  E-value: 4.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 242 LVGAPNVGKSSLVRILSTGKPEICNYPFTTR----GILMghiVLNYQRFQVTDTPGLLRRCDEDRNnlekLTLAVLTHLP 317
Cdd:PRK12298  164 LLGLPNAGKSTFIRAVSAAKPKVADYPFTTLvpnlGVVR---VDDERSFVVADIPGLIEGASEGAG----LGIRFLKHLE 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 318 -TAVLyVH--DLTGECGTSPSDQFQ-IYKEMkERFKDYL-----WIdAVSKCDLLggspvmyAKEDRSSDDAEIIKyrER 388
Cdd:PRK12298  237 rCRVL-LHliDIAPIDGSDPVENARiIINEL-EKYSPKLaekprWL-VFNKIDLL-------DEEEAEERAKAIVE--AL 304

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1063695625 389 GPDESIH-VSVKTEQGLNELKNKVKEVLSSEMEKIQSGEKTDQSV 432
Cdd:PRK12298  305 GWEGPVYlISAASGLGVKELCWDLMTFIEENPREEAEEAEAPEKV 349
MnmE COG0486
tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal ...
 190-419 1.31e-12

tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal structure and biogenesis]; tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440253 [Multi-domain]  Cd Length: 448  Bit Score: 69.32  E-value: 1.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 190 LSKKEAEERLSEGVEKLELVFQ--QQGgavddlltiaKVLRA-MPVVdlemptlcLVGAPNVGKSSLVRILS-------T 259
Cdd:COG0486   181 LDREELLERLEELREELEALLAsaRQG----------ELLREgIKVV--------IVGRPNVGKSSLLNALLgeeraivT 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 260 gkpeicNYPFTTRGILMGHIVLNYQRFQVTDTPGLlrRCDEDRnnLEKL----TLAVLThlpTA--VLYVHDLTGEcgtS 333
Cdd:COG0486   243 ------DIAGTTRDVIEERINIGGIPVRLIDTAGL--RETEDE--VEKIgierAREAIE---EAdlVLLLLDASEP---L 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 334 PSDQFQIYKEMKErfKDYLWIdaVSKCDLLGGSPvmyakedrssddaeiIKYRERGPDESIHVSVKTEQGLNELKNKVKE 413
Cdd:COG0486   307 TEEDEEILEKLKD--KPVIVV--LNKIDLPSEAD---------------GELKSLPGEPVIAISAKTGEGIDELKEAILE 367


                  ....*.
gi 1063695625 414 VLSSEM 419
Cdd:COG0486   368 LVGEGA 373
Gem1 COG1100
GTPase SAR1 family domain [General function prediction only];
240-420 5.34e-12

GTPase SAR1 family domain [General function prediction only];


Pssm-ID: 440717 [Multi-domain]  Cd Length: 177  Bit Score: 64.23  E-value: 5.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 240 LCLVGAPNVGKSSLVRILSTGKPEICNYPfTTRGILMGHIVLNYQ----RFQVTDTPGLLRRCDEDRNNLEKLTLAvlth 315
Cdd:COG1100     6 IVVVGTGGVGKTSLVNRLVGDIFSLEKYL-STNGVTIDKKELKLDgldvDLVIWDTPGQDEFRETRQFYARQLTGA---- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 316 lpTAVLYVHDLTgecgTSPSDQ--FQIYKEMKERFKDYLWIDAVSKCDLlggspvmYAKEDRSSDDAEIIKYRERGPDES 393
Cdd:COG1100    81 --SLYLFVVDGT----REETLQslYELLESLRRLGKKSPIILVLNKIDL-------YDEEEIEDEERLKEALSEDNIVEV 147

                         170       180
                  ....*....|....*....|....*..
gi 1063695625 394 IHVSVKTEQGLNELKNKVKEVLSSEME 420
Cdd:COG1100   148 VATSAKTGEGVEELFAALAEILRGEGD 174
trmE PRK05291
tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE;
242-426 1.39e-10

tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE;


Pssm-ID: 235392 [Multi-domain]  Cd Length: 449  Bit Score: 62.82  E-value: 1.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 242 LVGAPNVGKSSLVRILS-------TgkpeicNYPFTTRGILMGHIVLNYQRFQVTDTPGlLRrcdEDRNNLEKL----TL 310
Cdd:PRK05291  220 IAGRPNVGKSSLLNALLgeeraivT------DIAGTTRDVIEEHINLDGIPLRLIDTAG-IR---ETDDEVEKIgierSR 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 311 AvltHLPTA--VLYVHDLTGEcgtSPSDQFQIYKEMKErfKDYLWIdaVSKCDLLGGSPVmyakedrssddaeiikyRER 388
Cdd:PRK05291  290 E---AIEEAdlVLLVLDASEP---LTEEDDEILEELKD--KPVIVV--LNKADLTGEIDL-----------------EEE 342

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1063695625 389 GPDESIHVSVKTEQGLNELKNKVKEVLSSEMEKIQSGE 426
Cdd:PRK05291  343 NGKPVIRISAKTGEGIDELREAIKELAFGGFGGNQEGV 380
Rbg1 COG1163
Ribosome-interacting GTPase RBG1 [Translation, ribosomal structure and biogenesis];
239-296 1.63e-10

Ribosome-interacting GTPase RBG1 [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440777 [Multi-domain]  Cd Length: 368  Bit Score: 62.12  E-value: 1.63e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 239 TLCLVGAPNVGKSSLVRILSTGKPEICNYPFTTRGILMGhiVLNYQ--RFQVTDTPGLLR 296
Cdd:COG1163    65 TVVLVGFPSVGKSTLLNKLTNAKSEVGAYEFTTLDVVPG--MLEYKgaKIQILDVPGLIE 122
MnmE_helical pfam12631
MnmE helical domain; The tRNA modification GTPase MnmE consists of three domains. An ...
 196-418 2.52e-10

MnmE helical domain; The tRNA modification GTPase MnmE consists of three domains. An N-terminal domain, a helical domain and a GTPase domain which is nested within the helical domain. This family represents the helical domain.


Pssm-ID: 463649 [Multi-domain]  Cd Length: 326  Bit Score: 61.34  E-value: 2.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 196 EERLSEGVEKLElvfqqqgGAVDDLLTIA---KVLRampvvdlEMPTLCLVGAPNVGKSSLVRILS-------TgkpEIc 265
Cdd:pfam12631  64 EEELLERLEELL-------AELEKLLATAdrgRILR-------EGIKVVIVGKPNVGKSSLLNALLgeeraivT---DI- 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 266 nyPFTTRGILMGHIVLNYQRFQVTDTPGLlrRCDEDRnnLEKL----TLAvltHLPTA--VLYVHDLTgeCGTSPSDQfQ 339
Cdd:pfam12631 126 --PGTTRDVIEETINIGGIPLRLIDTAGI--RETDDE--VEKIgierARE---AIEEAdlVLLVLDAS--RPLDEEDL-E 193

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063695625 340 IYKEMKERfKDYLWIdaVSKCDLLGGSPVMYAKEDrssddaeiikyrergpDESIHVSVKTEQGLNELKNKVKEVLSSE 418
Cdd:pfam12631 194 ILELLKDK-KPIIVV--LNKSDLLGEIDELEELKG----------------KPVLAISAKTGEGLDELEEAIKELFLAG 253
era PRK00089
GTPase Era; Reviewed
 241-415 1.11e-08

GTPase Era; Reviewed


Pssm-ID: 234624 [Multi-domain]  Cd Length: 292  Bit Score: 56.21  E-value: 1.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 241 CLVGAPNVGKSSLV-RILS------TGKPEicnypfTTRGILMGhiVLNYQRFQV--TDTPGLLRRcdedRNNLEKLTL- 310
Cdd:PRK00089    9 AIVGRPNVGKSTLLnALVGqkisivSPKPQ------TTRHRIRG--IVTEDDAQIifVDTPGIHKP----KRALNRAMNk 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 311 AVLTHLPTA--VLYVHDLTGECGtsPSDQFqIYKEMKERFKDYlwIDAVSKCDLLggspvmyakEDRSSDDAEIIKYRER 388
Cdd:PRK00089   77 AAWSSLKDVdlVLFVVDADEKIG--PGDEF-ILEKLKKVKTPV--ILVLNKIDLV---------KDKEELLPLLEELSEL 142

                         170       180
                  ....*....|....*....|....*...
gi 1063695625 389 GPDESIH-VSVKTEQGLNELKNKVKEVL 415
Cdd:PRK00089  143 MDFAEIVpISALKGDNVDELLDVIAKYL 170
obgE PRK12296
GTPase CgtA; Reviewed
 235-332 1.15e-08

GTPase CgtA; Reviewed


Pssm-ID: 237045 [Multi-domain]  Cd Length: 500  Bit Score: 56.80  E-value: 1.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 235 LEMPTLC---LVGAPNVGKSSLVRILSTGKPEICNYPFTTRGILMGHIVLNYQRFQVTDTPGLLRRCDEDRNnlekLTLA 311
Cdd:PRK12296  154 LELKSVAdvgLVGFPSAGKSSLISALSAAKPKIADYPFTTLVPNLGVVQAGDTRFTVADVPGLIPGASEGKG----LGLD 229

                          90       100
                  ....*....|....*....|..
gi 1063695625 312 VLTHLP-TAVLyVHDLtgECGT 332
Cdd:PRK12296  230 FLRHIErCAVL-VHVV--DCAT 248
EngA1 cd01894
EngA1 GTPase contains the first domain of EngA; This EngA1 subfamily CD represents the first ...
 242-415 2.46e-08

EngA1 GTPase contains the first domain of EngA; This EngA1 subfamily CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Although the exact function of these proteins has not been elucidated, studies have revealed that the E. coli EngA homolog, Der, and Neisseria gonorrhoeae EngA are essential for cell viability. A recent report suggests that E. coli Der functions in ribosome assembly and stability.


Pssm-ID: 206681 [Multi-domain]  Cd Length: 157  Bit Score: 52.82  E-value: 2.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 242 LVGAPNVGKSSLV-RIlsTGKPE--ICNYPFTTRGILMGHIVLNYQRFQVTDTPGLlrrcDEDRNNLEKLTLA-VLTHLP 317
Cdd:cd01894     2 IVGRPNVGKSTLFnRL--TGRRDaiVSDTPGVTRDRKYGEAEWGGREFILIDTGGI----EPDDEGISKEIREqAEIAIE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 318 TA--VLYVHDltGECGTSPSDQfQIYKEMKERFKD-YLwidAVSKCDLLggspvmyakedrsSDDAEIIKYRERGPDESI 394
Cdd:cd01894    76 EAdvILFVVD--GREGLTPADE-EIAKYLRKSKKPvIL---VVNKIDNI-------------KEEEEAAEFYSLGFGEPI 136

                         170       180
                  ....*....|....*....|.
gi 1063695625 395 HVSVKTEQGLNELKNKVKEVL 415
Cdd:cd01894   137 PISAEHGRGIGDLLDAILELL 157
Era cd04163
E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is ...
 241-415 3.15e-08

E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly by chaperoning the 16S rRNA. It also contacts several assembly elements of the 30S subunit. Era couples cell growth with cytokinesis and plays a role in cell division and energy metabolism. Homologs have also been found in eukaryotes. Era contains two domains: the N-terminal GTPase domain and a C-terminal domain KH domain that is critical for RNA binding. Both domains are important for Era function. Era is functionally able to compensate for deletion of RbfA, a cold-shock adaptation protein that is required for efficient processing of the 16S rRNA.


Pssm-ID: 206726 [Multi-domain]  Cd Length: 168  Bit Score: 52.85  E-value: 3.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 241 CLVGAPNVGKSSLV-RIL------STGKPEicnypfTTRGILMGhiVLNYQRFQV--TDTPGLLRRCDEDRNNLEKLTLA 311
Cdd:cd04163     7 AIIGRPNVGKSTLLnALVgqkisiVSPKPQ------TTRNRIRG--IYTDDDAQIifVDTPGIHKPKKKLGERMVKAAWS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 312 VLTHLpTAVLYVHDLTGECGtsPSDQFqIYKEMKErfKDYLWIDAVSKCDLLggspvmyakEDRSSDDAEIIKYRERGP- 390
Cdd:cd04163    79 ALKDV-DLVLFVVDASEWIG--EGDEF-ILELLKK--SKTPVILVLNKIDLV---------KDKEDLLPLLEKLKELHPf 143

                         170       180
                  ....*....|....*....|....*
gi 1063695625 391 DESIHVSVKTEQGLNELKNKVKEVL 415
Cdd:cd04163   144 AEIFPISALKGENVDELLEYIVEYL 168
DRG cd01896
Developmentally Regulated GTP-binding protein (DRG); The developmentally regulated GTP-binding ...
 239-295 7.26e-08

Developmentally Regulated GTP-binding protein (DRG); The developmentally regulated GTP-binding protein (DRG) subfamily is an uncharacterized member of the Obg family, an evolutionary branch of GTPase superfamily proteins. GTPases act as molecular switches regulating diverse cellular processes. DRG2 and DRG1 comprise the DRG subfamily in eukaryotes. In view of their widespread expression in various tissues and high conservation among distantly related species in eukaryotes and archaea, DRG proteins may regulate fundamental cellular processes. It is proposed that the DRG subfamily proteins play their physiological roles through RNA binding.


Pssm-ID: 206683 [Multi-domain]  Cd Length: 233  Bit Score: 52.93  E-value: 7.26e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063695625 239 TLCLVGAPNVGKSSLVRILSTGKPEICNYPFTTRGILMGhiVLNYQ--RFQVTDTPGLL 295
Cdd:cd01896     2 RVALVGFPSVGKSTLLSKLTNTKSEVAAYEFTTLTCVPG--VMEYKgaKIQLLDLPGII 58
Der COG1160
Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];
238-294 8.47e-07

Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440774 [Multi-domain]  Cd Length: 438  Bit Score: 50.79  E-value: 8.47e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 238 PTLCLVGAPNVGKSSLV-RIlsTGKPE--ICNYPFTTRGILMGHIVLNYQRFQVTDTPGL 294
Cdd:COG1160     3 PVVAIVGRPNVGKSTLFnRL--TGRRDaiVDDTPGVTRDRIYGEAEWGGREFTLIDTGGI 60
PRK00093 PRK00093
GTP-binding protein Der; Reviewed
 237-420 1.04e-06

GTP-binding protein Der; Reviewed


Pssm-ID: 234628 [Multi-domain]  Cd Length: 435  Bit Score: 50.82  E-value: 1.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 237 MPTLCLVGAPNVGKSSLV-RIlsTGKPE--ICNYPFTTRGILMGHIVLNYQRFQVTDTPGLlrrcDEDRNNLEKLTLA-V 312
Cdd:PRK00093    1 KPVVAIVGRPNVGKSTLFnRL--TGKRDaiVADTPGVTRDRIYGEAEWLGREFILIDTGGI----EPDDDGFEKQIREqA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 313 LTHLPTA--VLYVHDltGECGTSPSDQfQIYKEMKERFKD-YLwidAVSKCDllggspvmyaKEDRSSDDAEIIKYrerG 389
Cdd:PRK00093   75 ELAIEEAdvILFVVD--GRAGLTPADE-EIAKILRKSNKPvIL---VVNKVD----------GPDEEADAYEFYSL---G 135

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1063695625 390 PDESIHVSVKTEQGLNELKNKVKEVLSSEME 420
Cdd:PRK00093  136 LGEPYPISAEHGRGIGDLLDAILEELPEEEE 166
Era COG1159
GTPase Era, involved in 16S rRNA processing [Translation, ribosomal structure and biogenesis];
241-415 2.40e-06

GTPase Era, involved in 16S rRNA processing [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440773 [Multi-domain]  Cd Length: 290  Bit Score: 48.83  E-value: 2.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 241 CLVGAPNVGKSSLV-RILS------TGKPEicnypfTTRGILMGhiVLNYQRFQV--TDTPGLLRRcdedRNNL-EKLTL 310
Cdd:COG1159     7 AIVGRPNVGKSTLLnALVGqkvsivSPKPQ------TTRHRIRG--IVTREDAQIvfVDTPGIHKP----KRKLgRRMNK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 311 AVLTHLPTA--VLYVHDLTGECGtsPSDQFqIYKEMKE-RFKDYLwidAVSKCDLLggspvmyAKEDRssdDAEIIKYRE 387
Cdd:COG1159    75 AAWSALEDVdvILFVVDATEKIG--EGDEF-ILELLKKlKTPVIL---VINKIDLV-------KKEEL---LPLLAEYSE 138

                         170       180
                  ....*....|....*....|....*....
gi 1063695625 388 RGPDESIH-VSVKTEQGLNELKNKVKEVL 415
Cdd:COG1159   139 LLDFAEIVpISALKGDNVDELLDEIAKLL 167
YeeP COG3596
Predicted GTPase [General function prediction only];
223-363 9.17e-06

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 47.45  E-value: 9.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 223 IAKVLRAMpVVDLEMPTLCLVGAPNVGKSSLVRIL--------STGKP---EICNYPFTTRGilMGHIVLnyqrfqvTDT 291
Cdd:COG3596    26 LAEALERL-LVELPPPVIALVGKTGAGKSSLINALfgaevaevGVGRPctrEIQRYRLESDG--LPGLVL-------LDT 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063695625 292 PGLlrrcdEDRNNLEKLTLAVLTHLPTA--VLYVHDltgecGTSPSDQ--FQIYKEMKERFKDYLWIDAVSKCDLL 363
Cdd:COG3596    96 PGL-----GEVNERDREYRELRELLPEAdlILWVVK-----ADDRALAtdEEFLQALRAQYPDPPVLVVLTQVDRL 161
FeoB_N pfam02421
Ferrous iron transport protein B; Escherichia coli has an iron(II) transport system (feo) ...
 239-293 3.18e-05

Ferrous iron transport protein B; Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent.


Pssm-ID: 460552 [Multi-domain]  Cd Length: 156  Bit Score: 43.98  E-value: 3.18e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063695625 239 TLCLVGAPNVGKSSLVRILSTGKPEICNYPFTTRGILMGHIVLNYQRFQVTDTPG 293
Cdd:pfam02421   2 TIALVGNPNVGKTTLFNALTGANQHVGNWPGVTVEKKEGKFKYKGYEIEIVDLPG 56
EngA2 cd01895
EngA2 GTPase contains the second domain of EngA; This EngA2 subfamily CD represents the second ...
 240-297 3.20e-05

EngA2 GTPase contains the second domain of EngA; This EngA2 subfamily CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Although the exact function of these proteins has not been elucidated, studies have revealed that the E. coli EngA homolog, Der, and Neisseria gonorrhoeae EngA are essential for cell viability. A recent report suggests that E. coli Der functions in ribosome assembly and stability.


Pssm-ID: 206682 [Multi-domain]  Cd Length: 174  Bit Score: 44.35  E-value: 3.20e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063695625 240 LCLVGAPNVGKSSLV-RILSTGKPEICNYPFTTRGILMGHIVLNYQRFQVTDTPGLLRR 297
Cdd:cd01895     5 IAIIGRPNVGKSSLLnALLGEERVIVSDIAGTTRDSIDVPFEYDGQKYTLIDTAGIRKK 63
FeoB cd01879
Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) ...
 241-293 7.94e-05

Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent.


Pssm-ID: 206667 [Multi-domain]  Cd Length: 159  Bit Score: 42.83  E-value: 7.94e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063695625 241 CLVGAPNVGKSSLVRILSTGKPEICNYPFTTRGILMGHIVLNYQRFQVTDTPG 293
Cdd:cd01879     1 ALVGNPNVGKTTLFNALTGARQKVGNWPGVTVEKKEGEFKLGGKEIEIVDLPG 53
RbgA COG1161
Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];
243-295 1.77e-04

Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440775 [Multi-domain]  Cd Length: 279  Bit Score: 43.17  E-value: 1.77e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063695625 243 VGAPNVGKSSLV------RILSTGkpeicNYPFTTRGilMGHIVLNyQRFQVTDTPGLL 295
Cdd:COG1161   119 VGIPNVGKSTLInrlagkKVAKTG-----NKPGVTKG--QQWIKLD-DGLELLDTPGIL 169
Der COG1160
Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];
217-297 1.92e-04

Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440774 [Multi-domain]  Cd Length: 438  Bit Score: 43.47  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 217 VDDLL-TIAKVLRAMPVVDLEMPT--LCLVGAPNVGKSSLV-RILstGK------PEicnyPFTTRGILMGHIVLNYQRF 286
Cdd:COG1160   152 VGDLLdAVLELLPEEEEEEEEDDPikIAIVGRPNVGKSSLInALL--GEervivsDI----AGTTRDSIDTPFERDGKKY 225

                          90
                  ....*....|.
gi 1063695625 287 QVTDTPGLLRR 297
Cdd:COG1160   226 TLIDTAGIRRK 236
FeoB COG0370
Fe2+ transporter FeoB [Inorganic ion transport and metabolism];
237-293 2.56e-04

Fe2+ transporter FeoB [Inorganic ion transport and metabolism];


Pssm-ID: 440139 [Multi-domain]  Cd Length: 662  Bit Score: 43.18  E-value: 2.56e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063695625 237 MPTLCLVGAPNVGKSSLVRILsTG-KPEICNYPFTTRGILMGHIVLNYQRFQVTDTPG 293
Cdd:COG0370     3 MITIALVGNPNVGKTTLFNAL-TGsRQKVGNWPGVTVEKKEGKFKLKGKEIELVDLPG 59
PRK09602 PRK09602
translation-associated GTPase; Reviewed
 237-271 3.54e-04

translation-associated GTPase; Reviewed


Pssm-ID: 236584 [Multi-domain]  Cd Length: 396  Bit Score: 42.49  E-value: 3.54e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1063695625 237 MPTLCLVGAPNVGKSSLVRILsTGKP-EICNYPFTT 271
Cdd:PRK09602    1 MITIGLVGKPNVGKSTFFNAA-TLADvEIANYPFTT 35
PRK03003 PRK03003
GTP-binding protein Der; Reviewed
 237-293 4.25e-04

GTP-binding protein Der; Reviewed


Pssm-ID: 179525 [Multi-domain]  Cd Length: 472  Bit Score: 42.65  E-value: 4.25e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 237 MPTLCLVGAPNVGKSSLV-RILstGKPE--ICNYPFTTRGILMGHIVLNYQRFQVTDTPG 293
Cdd:PRK03003   38 LPVVAVVGRPNVGKSTLVnRIL--GRREavVEDVPGVTRDRVSYDAEWNGRRFTVVDTGG 95
YlqF cd01856
Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs ...
 243-295 7.42e-04

Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The YlqF subfamily is represented in all eukaryotes as well as a phylogenetically diverse array of bacteria (including gram-positive bacteria, proteobacteria, Synechocystis, Borrelia, and Thermotoga).


Pssm-ID: 206749 [Multi-domain]  Cd Length: 171  Bit Score: 40.20  E-value: 7.42e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063695625 243 VGAPNVGKSSLV------RILSTGkpeicNYPFTTRGILMGHIVLNyqrFQVTDTPGLL 295
Cdd:cd01856   121 VGIPNVGKSTLInrlrgkKVAKVG-----NKPGVTRGQQWIRIGPN---IELLDTPGIL 171
PRK00093 PRK00093
GTP-binding protein Der; Reviewed
 217-297 9.22e-04

GTP-binding protein Der; Reviewed


Pssm-ID: 234628 [Multi-domain]  Cd Length: 435  Bit Score: 41.19  E-value: 9.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 217 VDDLL-TIAKVLRAMPVVDLEMPT--LCLVGAPNVGKSSLV-RILstGK------PEicnyPFTTRGILMGHIVLNYQRF 286
Cdd:PRK00093  150 IGDLLdAILEELPEEEEEDEEDEPikIAIIGRPNVGKSSLInALL--GEervivsDI----AGTTRDSIDTPFERDGQKY 223

                          90
                  ....*....|.
gi 1063695625 287 QVTDTPGLLRR 297
Cdd:PRK00093  224 TLIDTAGIRRK 234
YchF cd01900
YchF GTPase; YchF is a member of the Obg family, which includes four other subfamilies of ...
 243-271 9.56e-04

YchF GTPase; YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated with the ribosome. Several members of the family, including YchF, possess the TGS domain related to the RNA-binding proteins. Experimental data and genomic analysis suggest that YchF may be part of a nucleoprotein complex and may function as a GTP-dependent translational factor.


Pssm-ID: 206687 [Multi-domain]  Cd Length: 274  Bit Score: 40.91  E-value: 9.56e-04
                          10        20
                  ....*....|....*....|....*....
gi 1063695625 243 VGAPNVGKSSLVRILSTGKPEICNYPFTT 271
Cdd:cd01900     4 VGLPNVGKSTLFNALTKSNAEAANYPFCT 32
YqeH cd01855
Circularly permuted YqeH GTPase; YqeH is an essential GTP-binding protein. Depletion of YqeH ...
 242-294 1.19e-03

Circularly permuted YqeH GTPase; YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically present in bacteria with probable acquisition by plants from chloroplasts. Proteins of the YqeH family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases.


Pssm-ID: 206748 [Multi-domain]  Cd Length: 191  Bit Score: 39.94  E-value: 1.19e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063695625 242 LVGAPNVGKSSLV-RILSTG-----------KPEICNYPFTTRGILmgHIVLNYQRfQVTDTPGL 294
Cdd:cd01855   130 VVGATNVGKSTLInALLKSNggkvqaqalvqRLTVSPIPGTTLGLI--KIPLGEGK-KLYDTPGI 191
GTPase_YlqF TIGR03596
ribosome biogenesis GTP-binding protein YlqF; Members of this protein family are GTP-binding ...
 225-295 1.96e-03

ribosome biogenesis GTP-binding protein YlqF; Members of this protein family are GTP-binding proteins involved in ribosome biogenesis, including the essential YlqF protein of Bacillus subtilis, which is an essential protein. They are related to Era, EngA, and other GTPases of ribosome biogenesis, but are circularly permuted. This family is not universal, and is not present in Escherichia coli, and so is not as well studied as some other GTPases. This model is built for bacterial members. [Protein synthesis, Other]


Pssm-ID: 274669 [Multi-domain]  Cd Length: 276  Bit Score: 39.80  E-value: 1.96e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063695625 225 KVLRAMpvvdlemptlcLVGAPNVGKSSLV------RILSTGkpeicNYPFTTRGILMghIVLNyQRFQVTDTPGLL 295
Cdd:TIGR03596 117 RPIRAM-----------IVGIPNVGKSTLInrlagkKVAKVG-----NRPGVTKGQQW--IKLS-DNLELLDTPGIL 174
feoB TIGR00437
ferrous iron transporter FeoB; FeoB (773 amino acids in E. coli), a cytoplasmic membrane ...
 244-293 2.27e-03

ferrous iron transporter FeoB; FeoB (773 amino acids in E. coli), a cytoplasmic membrane protein required for iron(II) update, is encoded in an operon with FeoA (75 amino acids), which is also required, and is regulated by Fur. There appear to be two copies in Archaeoglobus fulgidus and Clostridium acetobutylicum. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273077 [Multi-domain]  Cd Length: 591  Bit Score: 40.11  E-value: 2.27e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1063695625 244 GAPNVGKSSLVRILSTGKPEICNYPFTTRGILMGHIVLNYQRFQVTDTPG 293
Cdd:TIGR00437   1 GNPNVGKSTLFNALTGANQTVGNWPGVTVEKKEGKLGFQGEDIEIVDLPG 50
GTP1 COG0012
Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis] ...
 242-271 3.02e-03

Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439783 [Multi-domain]  Cd Length: 362  Bit Score: 39.62  E-value: 3.02e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1063695625 242 LVGAPNVGKSSLVRILSTGKPEICNYPFTT 271
Cdd:COG0012     5 IVGLPNVGKSTLFNALTKAGAEAANYPFCT 34
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 240-356 3.04e-03

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 37.66  E-value: 3.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 240 LCLVGAPNVGKSSLVRILS---TGKP--EICNYPFTTRGILMGHIVLNYQRFQVTDTPgLLRR-------CDEDRNNLEK 307
Cdd:pfam07728   2 VLLVGPPGTGKTELAERLAaalSNRPvfYVQLTRDTTEEDLFGRRNIDPGGASWVDGP-LVRAaregeiaVLDEINRANP 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1063695625 308 LTLAVL-THLPTAVLYVHDLTGECGtSPSDQFQIYKEMKERFKDYLWIDA 356
Cdd:pfam07728  81 DVLNSLlSLLDERRLLLPDGGELVK-AAPDGFRLIATMNPLDRGLNELSP 129
small_GTP TIGR00231
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this ...
 242-308 3.79e-03

small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once.This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model. [Unknown function, General]


Pssm-ID: 272973 [Multi-domain]  Cd Length: 162  Bit Score: 38.12  E-value: 3.79e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063695625 242 LVGAPNVGKSSLVRILSTGKPEICNY-PFTTRGILMGHIVLN--YQRFQVTDTPGllrrcDEDRNNLEKL 308
Cdd:TIGR00231   6 IVGHPNVGKSTLLNSLLGNKGSITEYyPGTTRNYVTTVIEEDgkTYKFNLLDTAG-----QEDYDAIRRL 70
PTZ00258 PTZ00258
GTP-binding protein; Provisional
 242-271 8.16e-03

GTP-binding protein; Provisional


Pssm-ID: 240334 [Multi-domain]  Cd Length: 390  Bit Score: 38.39  E-value: 8.16e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1063695625 242 LVGAPNVGKSSLVRILSTGKPEICNYPFTT 271
Cdd:PTZ00258   26 IVGLPNVGKSTTFNALCKQQVPAENFPFCT 55
Ygr210 cd01899
Ygr210 GTPase; Ygr210 is a member of Obg-like family and present in archaea and fungi. They ...
 242-271 9.29e-03

Ygr210 GTPase; Ygr210 is a member of Obg-like family and present in archaea and fungi. They are characterized by a distinct glycine-rich motif immediately following the Walker B motif. The Ygr210 and YyaF/YchF subfamilies appear to form one major branch of the Obg-like family. Among eukaryotes, the Ygr210 subfamily is represented only in fungi. These fungal proteins form a tight cluster with their archaeal orthologs, which suggests the possibility of horizontal transfer from archaea to fungi.


Pssm-ID: 206686 [Multi-domain]  Cd Length: 318  Bit Score: 37.98  E-value: 9.29e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1063695625 242 LVGAPNVGKSSLVRILSTGKPEICNYPFTT 271
Cdd:cd01899     3 LVGKPNVGKSTFFNAATLADVEIANYPFTT 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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