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Conserved domains on  [gi|1061214005|ref|NP_001317614|]
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DNA-directed RNA polymerase III subunit RPC7-like isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RNA_pol_3_Rpc31 super family cl13200
DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits ...
37-181 9.25e-03

DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits in yeasts and in human cells. Twelve of these are akin to RNA polymerase I or II and the other five are RNA pol III-specific, and form the functionally distinct groups (i) Rpc31-Rpc34-Rpc82, and (ii) Rpc37-Rpc53. Rpc31, Rpc34 and Rpc82 form a cluster of enzyme-specific subunits that contribute to transcription initiation in S.cerevisiae and H.sapiens. There is evidence that these subunits are anchored at or near the N-terminal Zn-fold of Rpc1, itself prolonged by a highly conserved but RNA polymerase III-specific domain.


The actual alignment was detected with superfamily member pfam11705:

Pssm-ID: 463324  Cd Length: 213  Bit Score: 35.81  E-value: 9.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061214005  37 PSPLFPPLeFRPVPLPSGEEGEYVLALKQELRGAMRQLPYFI-----------------------------------RPA 81
Cdd:pfam11705  15 PSPLFPPY-PLPVALPLTERERYQVALYLLFREQMHDGPFYTgsrtskstgpkgvktkatfdpfdgierysdkylkkERI 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061214005  82 VPKRDWR-----RLPRELKIRVRKLQ-----KERITILLPKRPPKTTEDKEETIQKLETLEKKEEEVTSEEDEEKEEEEE 151
Cdd:pfam11705  94 LPSLDERpfvkeFFPKELWPTLDGDDvgiakKKKKKLGLSKVKSLRNAEDEGEEEEEEEAKGLSLLEKLKDLAEDEDDED 173
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1061214005 152 KEE---------EEEEEYDEEEHEEETDY-IMSYFDNGED 181
Cdd:pfam11705 174 EKEeedeegeeeIEDEDFEDDDEDDGGDYnAEKYFDNGDD 213
 
Name Accession Description Interval E-value
RNA_pol_3_Rpc31 pfam11705
DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits ...
37-181 9.25e-03

DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits in yeasts and in human cells. Twelve of these are akin to RNA polymerase I or II and the other five are RNA pol III-specific, and form the functionally distinct groups (i) Rpc31-Rpc34-Rpc82, and (ii) Rpc37-Rpc53. Rpc31, Rpc34 and Rpc82 form a cluster of enzyme-specific subunits that contribute to transcription initiation in S.cerevisiae and H.sapiens. There is evidence that these subunits are anchored at or near the N-terminal Zn-fold of Rpc1, itself prolonged by a highly conserved but RNA polymerase III-specific domain.


Pssm-ID: 463324  Cd Length: 213  Bit Score: 35.81  E-value: 9.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061214005  37 PSPLFPPLeFRPVPLPSGEEGEYVLALKQELRGAMRQLPYFI-----------------------------------RPA 81
Cdd:pfam11705  15 PSPLFPPY-PLPVALPLTERERYQVALYLLFREQMHDGPFYTgsrtskstgpkgvktkatfdpfdgierysdkylkkERI 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061214005  82 VPKRDWR-----RLPRELKIRVRKLQ-----KERITILLPKRPPKTTEDKEETIQKLETLEKKEEEVTSEEDEEKEEEEE 151
Cdd:pfam11705  94 LPSLDERpfvkeFFPKELWPTLDGDDvgiakKKKKKLGLSKVKSLRNAEDEGEEEEEEEAKGLSLLEKLKDLAEDEDDED 173
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1061214005 152 KEE---------EEEEEYDEEEHEEETDY-IMSYFDNGED 181
Cdd:pfam11705 174 EKEeedeegeeeIEDEDFEDDDEDDGGDYnAEKYFDNGDD 213
 
Name Accession Description Interval E-value
RNA_pol_3_Rpc31 pfam11705
DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits ...
37-181 9.25e-03

DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits in yeasts and in human cells. Twelve of these are akin to RNA polymerase I or II and the other five are RNA pol III-specific, and form the functionally distinct groups (i) Rpc31-Rpc34-Rpc82, and (ii) Rpc37-Rpc53. Rpc31, Rpc34 and Rpc82 form a cluster of enzyme-specific subunits that contribute to transcription initiation in S.cerevisiae and H.sapiens. There is evidence that these subunits are anchored at or near the N-terminal Zn-fold of Rpc1, itself prolonged by a highly conserved but RNA polymerase III-specific domain.


Pssm-ID: 463324  Cd Length: 213  Bit Score: 35.81  E-value: 9.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061214005  37 PSPLFPPLeFRPVPLPSGEEGEYVLALKQELRGAMRQLPYFI-----------------------------------RPA 81
Cdd:pfam11705  15 PSPLFPPY-PLPVALPLTERERYQVALYLLFREQMHDGPFYTgsrtskstgpkgvktkatfdpfdgierysdkylkkERI 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061214005  82 VPKRDWR-----RLPRELKIRVRKLQ-----KERITILLPKRPPKTTEDKEETIQKLETLEKKEEEVTSEEDEEKEEEEE 151
Cdd:pfam11705  94 LPSLDERpfvkeFFPKELWPTLDGDDvgiakKKKKKLGLSKVKSLRNAEDEGEEEEEEEAKGLSLLEKLKDLAEDEDDED 173
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1061214005 152 KEE---------EEEEEYDEEEHEEETDY-IMSYFDNGED 181
Cdd:pfam11705 174 EKEeedeegeeeIEDEDFEDDDEDDGGDYnAEKYFDNGDD 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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