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Conserved domains on  [gi|1057503103|ref|NP_001317211|]
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mitotic-spindle organizing protein 2B isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MOZART2 super family cl15169
Mitotic-spindle organizing gamma-tubulin ring associated; FAM128A and FAM128B proteins have ...
 9-96 1.58e-36

Mitotic-spindle organizing gamma-tubulin ring associated; FAM128A and FAM128B proteins have been re-named MOZART2A and B. The name MOZART is derived from letters of 'mitotic-spindle organizing proteins associated with a ring of gamma-tubulin'. This family operates as part of the gamma-tubulin ring complex, gamma-TuRC, one of the complexes necessary for chromosome segregation. This complex is located at centrosomes and mediates the formation of bipolar spindles in mitosis; it consists of six subunits. However, unlike the other four known subunits, the MOZART proteins, both 1 and 2, do not carry the conserved 'Spc97-Spc98' GCP domain, so the TUBCGP nomenclature cannot be used for it. The exact function of MOZART2 is not clear.


The actual alignment was detected with superfamily member pfam12926:

Pssm-ID: 432879  Cd Length: 90  Bit Score: 123.42  E-value: 1.58e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503103   9 GPGSAAPPGLEAARQKLALRRKKVLSTEEMELYELAQAAGGAIDPDVFKILVDLLKLNVAPLAVFQMLKSMCAGQRLA-S 87
Cdd:pfam12926   2 APGTSPSLVVSGNVQKYAIKKKKVLNAEEMELYELTQAAGIVIDQEVFKIIVDLLKMNVAPLAVFQTLKSMCAGQRVSeS 81


                  ....*....
gi 1057503103  88 EPQDPAAVS 96
Cdd:pfam12926  82 SGGDTSSAS 90
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 84-214 3.47e-03

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 38.13  E-value: 3.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503103  84 RLASEPQDPAAVSLPTSS-VPET--REASFLSARNSSPPARPsfsSSPQPAASPvllHSPAATHSPLSPGPPGSLRLSCC 160
Cdd:PTZ00449  601 RSAQRPTRPKSPKLPELLdIPKSpkRPESPKSPKRPPPPQRP---SSPERPEGP---KIIKSPKPPKSPKPPFDPKFKEK 674

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1057503103 161 LFSPF---AGRNKGSAALGGALALAERSSREGSSQ--------------RMPRQPSATRLPKGGGPGKSPT 214
Cdd:PTZ00449  675 FYDDYldaAAKSKETKTTVVLDESFESILKETLPEtpgtpfttprplppKLPRDEEFPFEPIGDPDAEQPD 745
 
Name Accession Description Interval E-value
MOZART2 pfam12926
Mitotic-spindle organizing gamma-tubulin ring associated; FAM128A and FAM128B proteins have ...
 9-96 1.58e-36

Mitotic-spindle organizing gamma-tubulin ring associated; FAM128A and FAM128B proteins have been re-named MOZART2A and B. The name MOZART is derived from letters of 'mitotic-spindle organizing proteins associated with a ring of gamma-tubulin'. This family operates as part of the gamma-tubulin ring complex, gamma-TuRC, one of the complexes necessary for chromosome segregation. This complex is located at centrosomes and mediates the formation of bipolar spindles in mitosis; it consists of six subunits. However, unlike the other four known subunits, the MOZART proteins, both 1 and 2, do not carry the conserved 'Spc97-Spc98' GCP domain, so the TUBCGP nomenclature cannot be used for it. The exact function of MOZART2 is not clear.


Pssm-ID: 432879  Cd Length: 90  Bit Score: 123.42  E-value: 1.58e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503103   9 GPGSAAPPGLEAARQKLALRRKKVLSTEEMELYELAQAAGGAIDPDVFKILVDLLKLNVAPLAVFQMLKSMCAGQRLA-S 87
Cdd:pfam12926   2 APGTSPSLVVSGNVQKYAIKKKKVLNAEEMELYELTQAAGIVIDQEVFKIIVDLLKMNVAPLAVFQTLKSMCAGQRVSeS 81


                  ....*....
gi 1057503103  88 EPQDPAAVS 96
Cdd:pfam12926  82 SGGDTSSAS 90
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 84-214 3.47e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 38.13  E-value: 3.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503103  84 RLASEPQDPAAVSLPTSS-VPET--REASFLSARNSSPPARPsfsSSPQPAASPvllHSPAATHSPLSPGPPGSLRLSCC 160
Cdd:PTZ00449  601 RSAQRPTRPKSPKLPELLdIPKSpkRPESPKSPKRPPPPQRP---SSPERPEGP---KIIKSPKPPKSPKPPFDPKFKEK 674

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1057503103 161 LFSPF---AGRNKGSAALGGALALAERSSREGSSQ--------------RMPRQPSATRLPKGGGPGKSPT 214
Cdd:PTZ00449  675 FYDDYldaAAKSKETKTTVVLDESFESILKETLPEtpgtpfttprplppKLPRDEEFPFEPIGDPDAEQPD 745
 
Name Accession Description Interval E-value
MOZART2 pfam12926
Mitotic-spindle organizing gamma-tubulin ring associated; FAM128A and FAM128B proteins have ...
 9-96 1.58e-36

Mitotic-spindle organizing gamma-tubulin ring associated; FAM128A and FAM128B proteins have been re-named MOZART2A and B. The name MOZART is derived from letters of 'mitotic-spindle organizing proteins associated with a ring of gamma-tubulin'. This family operates as part of the gamma-tubulin ring complex, gamma-TuRC, one of the complexes necessary for chromosome segregation. This complex is located at centrosomes and mediates the formation of bipolar spindles in mitosis; it consists of six subunits. However, unlike the other four known subunits, the MOZART proteins, both 1 and 2, do not carry the conserved 'Spc97-Spc98' GCP domain, so the TUBCGP nomenclature cannot be used for it. The exact function of MOZART2 is not clear.


Pssm-ID: 432879  Cd Length: 90  Bit Score: 123.42  E-value: 1.58e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503103   9 GPGSAAPPGLEAARQKLALRRKKVLSTEEMELYELAQAAGGAIDPDVFKILVDLLKLNVAPLAVFQMLKSMCAGQRLA-S 87
Cdd:pfam12926   2 APGTSPSLVVSGNVQKYAIKKKKVLNAEEMELYELTQAAGIVIDQEVFKIIVDLLKMNVAPLAVFQTLKSMCAGQRVSeS 81


                  ....*....
gi 1057503103  88 EPQDPAAVS 96
Cdd:pfam12926  82 SGGDTSSAS 90
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 84-214 3.47e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 38.13  E-value: 3.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057503103  84 RLASEPQDPAAVSLPTSS-VPET--REASFLSARNSSPPARPsfsSSPQPAASPvllHSPAATHSPLSPGPPGSLRLSCC 160
Cdd:PTZ00449  601 RSAQRPTRPKSPKLPELLdIPKSpkRPESPKSPKRPPPPQRP---SSPERPEGP---KIIKSPKPPKSPKPPFDPKFKEK 674

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1057503103 161 LFSPF---AGRNKGSAALGGALALAERSSREGSSQ--------------RMPRQPSATRLPKGGGPGKSPT 214
Cdd:PTZ00449  675 FYDDYldaAAKSKETKTTVVLDESFESILKETLPEtpgtpfttprplppKLPRDEEFPFEPIGDPDAEQPD 745
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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