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Conserved domains on  [gi|1053796179|ref|WP_066065237|]
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sulfurtransferase TusA family protein [Candidatus Desulfofervidus auxilii]

Protein Classification

sulfurtransferase TusA family protein( domain architecture ID 10001403)

sulfurtransferase TusA family protein similar to sulfurtransferase TusA, which interacts with cysteine desulfurase IscS and acts as the first member in a sulfur relay mechanism, transfering sulfur to the TusBCD complex

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TusA COG0425
Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ...
 7-72 6.07e-22

Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ribosomal structure and biogenesis, Coenzyme transport and metabolism, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440194  Cd Length: 70  Bit Score: 79.85  E-value: 6.07e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1053796179  7 LDVCGEVCPMPVIKTKAMLDKMGPGEVLEVIVDYAPSKENVKRLAQSQGCKV--KIEEGEKIKIIIEK 72
Cdd:COG0425    1 LDARGLSCPLPVLKTKKALEELKPGEVLEVLADDPGAVEDIPAWCRETGHELlsVEEEGGVYRILIRK 68
 
Name Accession Description Interval E-value
TusA COG0425
Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ...
 7-72 6.07e-22

Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ribosomal structure and biogenesis, Coenzyme transport and metabolism, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440194  Cd Length: 70  Bit Score: 79.85  E-value: 6.07e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1053796179  7 LDVCGEVCPMPVIKTKAMLDKMGPGEVLEVIVDYAPSKENVKRLAQSQGCKV--KIEEGEKIKIIIEK 72
Cdd:COG0425    1 LDARGLSCPLPVLKTKKALEELKPGEVLEVLADDPGAVEDIPAWCRETGHELlsVEEEGGVYRILIRK 68
SirA_YedF_YeeD cd00291
SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and ...
 6-72 3.52e-21

SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is suggested to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 238180  Cd Length: 69  Bit Score: 77.98  E-value: 3.52e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1053796179  6 TLDVCGEVCPMPVIKTKAMLDKMGPGEVLEVIVDYAPSKENVKRLAQSQGCKVKI--EEGEKIKIIIEK 72
Cdd:cd00291    1 TLDLRGLPCPLPVLKTKKALEKLKSGEVLEVLLDDPGAVEDIPAWAKETGHEVLEveEEGGVYRILIRK 69
TusA pfam01206
Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.
 6-66 1.45e-19

Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.


Pssm-ID: 426125  Cd Length: 64  Bit Score: 73.76  E-value: 1.45e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1053796179  6 TLDVCGEVCPMPVIKTKAMLDKMGPGEVLEVIVDYAPSKENVKRLAQSQGCKV-KIEEGEKI 66
Cdd:pfam01206  1 TLDLRGLACPMPLLKTKKALKKLKPGEVLEVLADDPGAVEDIPRWAKETGHEVlEVEEEDGE 62
selenium_YedF TIGR03527
selenium metabolism protein YedF; Members of this protein family are about 200 amino acids in ...
 7-71 1.53e-19

selenium metabolism protein YedF; Members of this protein family are about 200 amino acids in size, and include the uncharacterized YedF protein of Escherichia coli. This family shares an N-terminal domain, modeled by pfam01206, with the sulfurtransferase TusA (also called SirA). The C-terminal domain includes a typical redox-active disulfide motif, CGXC. This protein family found only among those genomes that also carry the selenium donor protein SelD, and its connection to selenium metabolism is indicated by the method of partial phylogenetic profiling vs. SelD. Its gene typically is found next to selD. Members of this family are found even when selenocysteine and selenouridine biosynthesis pathways are, except for SelD, completely absent, as in Enterococcus faecalis. Its role in selenium metabolism is unclear, but may include either detoxification or a role in labile selenoprotein biosynthesis.


Pssm-ID: 274630 [Multi-domain]  Cd Length: 194  Bit Score: 77.28  E-value: 1.53e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1053796179   7 LDVCGEVCPMPVIKTKAMLDKMGPGEVLEVIVDYAPSKENVKRLAQSQGCKVKIEEGEKIKIIIE 71
Cdd:TIGR03527   1 IDARGLACPQPVILTKKALDELGEEGVLTVIVDNEAAKENVSKFATSLGYEVEVEEKEEGYWILI 65
PRK11018 PRK11018
putative sulfurtransferase YedF;
3-72 4.67e-13

putative sulfurtransferase YedF;


Pssm-ID: 236822  Cd Length: 78  Bit Score: 57.75  E-value: 4.67e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1053796179  3 KRYTLDVCGEVCPMPVIKTKAMLDKMGPGEVLEVIVDYAPSKENVKRLAQSQGCKV-KIE-EGEKIKIIIEK 72
Cdd:PRK11018   7 PDYRLDMVGEPCPYPAVATLEALPQLKKGEILEVVSDCPQSINNIPLDARNHGYTVlDIQqDGPTIRYLIQK 78
 
Name Accession Description Interval E-value
TusA COG0425
Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ...
 7-72 6.07e-22

Sulfur carrier protein TusA (tRNA thiolation, molybdenum cofactor biosynthesis) [Translation, ribosomal structure and biogenesis, Coenzyme transport and metabolism, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440194  Cd Length: 70  Bit Score: 79.85  E-value: 6.07e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1053796179  7 LDVCGEVCPMPVIKTKAMLDKMGPGEVLEVIVDYAPSKENVKRLAQSQGCKV--KIEEGEKIKIIIEK 72
Cdd:COG0425    1 LDARGLSCPLPVLKTKKALEELKPGEVLEVLADDPGAVEDIPAWCRETGHELlsVEEEGGVYRILIRK 68
SirA_YedF_YeeD cd00291
SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and ...
 6-72 3.52e-21

SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is suggested to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 238180  Cd Length: 69  Bit Score: 77.98  E-value: 3.52e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1053796179  6 TLDVCGEVCPMPVIKTKAMLDKMGPGEVLEVIVDYAPSKENVKRLAQSQGCKVKI--EEGEKIKIIIEK 72
Cdd:cd00291    1 TLDLRGLPCPLPVLKTKKALEKLKSGEVLEVLLDDPGAVEDIPAWAKETGHEVLEveEEGGVYRILIRK 69
TusA pfam01206
Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.
 6-66 1.45e-19

Sulfurtransferase TusA; This family includes the TusA sulfurtransferases.


Pssm-ID: 426125  Cd Length: 64  Bit Score: 73.76  E-value: 1.45e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1053796179  6 TLDVCGEVCPMPVIKTKAMLDKMGPGEVLEVIVDYAPSKENVKRLAQSQGCKV-KIEEGEKI 66
Cdd:pfam01206  1 TLDLRGLACPMPLLKTKKALKKLKPGEVLEVLADDPGAVEDIPRWAKETGHEVlEVEEEDGE 62
selenium_YedF TIGR03527
selenium metabolism protein YedF; Members of this protein family are about 200 amino acids in ...
 7-71 1.53e-19

selenium metabolism protein YedF; Members of this protein family are about 200 amino acids in size, and include the uncharacterized YedF protein of Escherichia coli. This family shares an N-terminal domain, modeled by pfam01206, with the sulfurtransferase TusA (also called SirA). The C-terminal domain includes a typical redox-active disulfide motif, CGXC. This protein family found only among those genomes that also carry the selenium donor protein SelD, and its connection to selenium metabolism is indicated by the method of partial phylogenetic profiling vs. SelD. Its gene typically is found next to selD. Members of this family are found even when selenocysteine and selenouridine biosynthesis pathways are, except for SelD, completely absent, as in Enterococcus faecalis. Its role in selenium metabolism is unclear, but may include either detoxification or a role in labile selenoprotein biosynthesis.


Pssm-ID: 274630 [Multi-domain]  Cd Length: 194  Bit Score: 77.28  E-value: 1.53e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1053796179   7 LDVCGEVCPMPVIKTKAMLDKMGPGEVLEVIVDYAPSKENVKRLAQSQGCKVKIEEGEKIKIIIE 71
Cdd:TIGR03527   1 IDARGLACPQPVILTKKALDELGEEGVLTVIVDNEAAKENVSKFATSLGYEVEVEEKEEGYWILI 65
SirA_like_N cd03421
SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, ...
 6-72 3.68e-18

SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is suggested to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 239513  Cd Length: 67  Bit Score: 70.31  E-value: 3.68e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1053796179  6 TLDVCGEVCPMPVIKTKAMLDKmGPGEVLEVIVDYAPSKENVKRLAQSQGCKVKIEE-GEKIKIIIEK 72
Cdd:cd03421    1 TIDARGLACPQPVIKTKKALEL-EAGGEIEVLVDNEVAKENVSRFAESRGYEVSVEEkGGEFEITITK 67
PRK11018 PRK11018
putative sulfurtransferase YedF;
3-72 4.67e-13

putative sulfurtransferase YedF;


Pssm-ID: 236822  Cd Length: 78  Bit Score: 57.75  E-value: 4.67e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1053796179  3 KRYTLDVCGEVCPMPVIKTKAMLDKMGPGEVLEVIVDYAPSKENVKRLAQSQGCKV-KIE-EGEKIKIIIEK 72
Cdd:PRK11018   7 PDYRLDMVGEPCPYPAVATLEALPQLKKGEILEVVSDCPQSINNIPLDARNHGYTVlDIQqDGPTIRYLIQK 78
YedF cd03422
YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and ...
 7-72 4.95e-10

YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A variety of microorganisms have similar proteins, all of which contain a common CPxP sequence motif in the N-terminal region. YhhP is suggested to be important for normal cell division and growth in rich nutrient medium. Moreover, despite a low primary sequence similarity, the YccP structure closely resembles the non-homologous C-terminal RNA-binding domain of E. coli translation initiation factor IF3. The signature CPxP motif serves to stabilize the N-terminal helix as part of the N-capping box and might be important in mRNA-binding.


Pssm-ID: 239514  Cd Length: 69  Bit Score: 49.73  E-value: 4.95e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1053796179  7 LDVCGEVCPMPVIKTKAMLDKMGPGEVLEVIVDYAPSKENVKRLAQSQGCKV-KIEE-GEKIKIIIEK 72
Cdd:cd03422    2 LDLRGEPCPYPAIATLEALPSLKPGEILEVISDCPQSINNIPIDARNHGYKVlAIEQsGPTIRYLIQK 69
SirA_RHOD_Pry_redox cd03420
SirA_RHOD_Pry_redox. SirA-like domain located within a multidomain protein of unknown ...
 6-72 1.21e-05

SirA_RHOD_Pry_redox. SirA-like domain located within a multidomain protein of unknown function. Other domains include RHOD (rhodanese homology domain), and Pry_redox (pyridine nucleotide-disulphide oxidoreductase) as well as a C-terminal domain that corresponds to COG2210. This fold is referred to as a two-layered alpha/beta sandwich, structurally similar to that of translation initiation factor 3.


Pssm-ID: 239512  Cd Length: 69  Bit Score: 38.51  E-value: 1.21e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1053796179  6 TLDVCGEVCPMPVIKTKAMLDKMGPGEVLEVIVDYAPSKENVKRLAQSQGCKV--KIEEGEKIKIIIEK 72
Cdd:cd03420    1 EVDACGLQCPGPILKLKKEIDKLQDGEQLEVKASDPGFARDAQAWCKSTGNTLisLETEKGKVKAVIEK 69
PRK00299 PRK00299
sulfurtransferase TusA;
6-39 4.27e-03

sulfurtransferase TusA;


Pssm-ID: 178967  Cd Length: 81  Bit Score: 32.30  E-value: 4.27e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 1053796179  6 TLDVCGEVCPMPVIKTKAMLDKMGPGEVLEVIVD 39
Cdd:PRK00299  11 TLDALGLRCPEPVMMVRKTVRNMQPGETLLIIAD 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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