|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
473-712 |
2.63e-16 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 82.67 E-value: 2.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 473 KAIDLSLNNIFFIGQKQFKDFPKIACLNLSSNgngqalngSEFSALSHLKYLDFSHNKLDfDADSAFNELPELEVLDLSN 552
Cdd:COG4886 75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSN 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 553 NEhyfqiagVTHRLGFIKNLTKLKVLNVSQNNIYTLTEYNLSSSSLKQLVFSGNRLDVLWKAadkrymciFRNLNVLEEL 632
Cdd:COG4886 146 NQ-------LTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP--------LGNLTNLEEL 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 633 DMSFNNLERIPKqAFINLPrNLTKLYLNDNKLRFFNWtlLLHFPQLQLLDLSRNCLYYLTDSLSkiASSLQTLLLSENII 712
Cdd:COG4886 211 DLSGNQLTDLPE-PLANLT-NLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLAN--LTNLKTLDLSNNQL 284
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
154-727 |
2.91e-16 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 84.13 E-value: 2.91e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 154 STSGLRNLEILNLGWNCYFGNVcnktfnADGAFEEMANLKELTLSFNNLS-RVPRNLPRSLTKLYLSNTNINAVRRADFE 232
Cdd:PLN00113 88 AIFRLPYIQTINLSNNQLSGPI------PDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIG 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 233 NLGNLTVLDLSGNCprcfnapfpcipCPGDASISIDgnafdNLTQLEYLNLSSTSLRKVNSSWFNKMRDLKELHLEFNYL 312
Cdd:PLN00113 162 SFSSLKVLDLGGNV------------LVGKIPNSLT-----NLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 313 VQEIASGefLTKLPSLEILDLSYNYVKTQylefitLSPNFSKLTCLRSLHLrgyvFQ-KLRYKDFQPLMNLSKLTTINLG 391
Cdd:PLN00113 225 SGEIPYE--IGGLTSLNHLDLVYNNLTGP------IPSSLGNLKNLQYLFL----YQnKLSGPIPPSIFSLQKLISLDLS 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 392 VNFINQIDFTIFKQPKHLNVIYLSANRISPLVNGTRQSSVRLsaghsHVLKPRSAD------SDFDPHSNFyhstkplik 465
Cdd:PLN00113 293 DNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRL-----QVLQLWSNKfsgeipKNLGKHNNL--------- 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 466 pecvrygKAIDLSLNNIFFIGQKQFKDFPKIACLNLSSNgngqALNGS---EFSALSHLKYLDFSHNKLDFDADSAFNEL 542
Cdd:PLN00113 359 -------TVLDLSTNNLTGEIPEGLCSSGNLFKLILFSN----SLEGEipkSLGACRSLRRVRLQDNSFSGELPSEFTKL 427
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 543 PELEVLDLSNNEhyfqiagVTHRLGFIK-NLTKLKVLNVSQNNIYTLTEYNLSSSSLKQLVFSGNRLDvlwKAADKRymc 621
Cdd:PLN00113 428 PLVYFLDISNNN-------LQGRINSRKwDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFS---GAVPRK--- 494
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 622 iFRNLNVLEELDMSFNNLE-RIPKQafINLPRNLTKLYLNDNKLRFFNWTLLLHFPQLQLLDLSRNCLY-YLTDSLSKIA 699
Cdd:PLN00113 495 -LGSLSELMQLKLSENKLSgEIPDE--LSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVE 571
|
570 580 590
....*....|....*....|....*....|
gi 1052247119 700 SSLQTLLLSENIIAHMPS--GFVSENSSLV 727
Cdd:PLN00113 572 SLVQVNISHNHLHGSLPStgAFLAINASAV 601
|
|
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
868-1004 |
1.32e-15 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 74.67 E-value: 1.32e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 868 YDAYVSYdtkdaSVTDWVINELRFHLEESEEKNVLlCLEERDWDPGLAIIDNLMQSINQSKKTIFVLTRKYARSWSFKTA 947
Cdd:smart00255 2 YDVFISY-----SGKEDVRNEFLSHLLEKLRGYGL-CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1052247119 948 FYLALQRLMDENMDVIVFILLEP----VLQHSQYLRLRQRIcksSILQWPDNPKAEvlFWQ 1004
Cdd:smart00255 76 LVAALENALEEGGLRVIPIFYEVipsdVRKQPGKFRKVFKK---NYLKWPEDEKEQ--FWK 131
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
111-401 |
2.11e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 79.59 E-value: 2.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 111 LNLQKLTELLLENNQLDKIPSGLPGSLRWLSLTQNEIVSVTKNSTSGLRNLEILNLGWNcyfgnvcnktfnadGAFEEMA 190
Cdd:COG4886 48 LLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN--------------EELSNLT 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 191 NLKELTLSFNNLSRVPRNLPR--SLTKLYLSNTNINAVrRADFENLGNLTVLDLSGNcprcfnapfpcipcpgdaSISID 268
Cdd:COG4886 114 NLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNN------------------QLTDL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 269 GNAFDNLTQLEYLNLSSTSLRKVnSSWFNKMRDLKELHLEFNYLvQEIasGEFLTKLPSLEILDLSYNYVKTQylefitl 348
Cdd:COG4886 175 PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQL-TDL--PEPLANLTNLETLDLSNNQLTDL------- 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1052247119 349 sPNFSKLTCLRSLHLRGyvfqkLRYKDFQPLMNLSKLTTINLGVNFINQIDFT 401
Cdd:COG4886 244 -PELGNLTNLEELDLSN-----NQLTDLPPLANLTNLKTLDLSNNQLTDLKLK 290
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
53-245 |
5.50e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 78.44 E-value: 5.50e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 53 DVTELDLSDNSITHITNgSFRRLHNLTTINLNRNamlppyfenyrrnkkgmNITD--GAFLNLQKLTELLLENNQLDKIP 130
Cdd:COG4886 114 NLESLDLSGNQLTDLPE-ELANLTNLKELDLSNN-----------------QLTDlpEPLGNLTNLKSLDLSNNQLTDLP 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 131 SGLPG--SLRWLSLTQNEIVSVTKnSTSGLRNLEILNLGwncyfgnvCNKTFNADGAFEEMANLKELTLSFNNLSRVPR- 207
Cdd:COG4886 176 EELGNltNLKELDLSNNQITDLPE-PLGNLTNLEELDLS--------GNQLTDLPEPLANLTNLETLDLSNNQLTDLPEl 246
|
170 180 190
....*....|....*....|....*....|....*....
gi 1052247119 208 -NLPrSLTKLYLSNTNINAVrrADFENLGNLTVLDLSGN 245
Cdd:COG4886 247 gNLT-NLEELDLSNNQLTDL--PPLANLTNLKTLDLSNN 282
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
493-737 |
1.05e-09 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 61.22 E-value: 1.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 493 FPKIACLNlSSNGNGQALNGSEFSALS-------HLKYLDFSHNKLDFDAD------SAFNELPELEVLDLSNNehYFQI 559
Cdd:cd00116 19 LPKLLCLQ-VLRLEGNTLGEEAAKALAsalrpqpSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDN--ALGP 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 560 AGVthrlGFIKNLTK---LKVLNVSQNNIYTLTEYNL------SSSSLKQLVFSGNRLDVlwkAADKRYMCIFRNLNVLE 630
Cdd:cd00116 96 DGC----GVLESLLRsssLQELKLNNNGLGDRGLRLLakglkdLPPALEKLVLGRNRLEG---ASCEALAKALRANRDLK 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 631 ELDMSFNNL--ERIP--KQAFINLPrNLTKLYLNDNKLRFFNWTLL----LHFPQLQLLDLSRN-----CLYYLTDSLSK 697
Cdd:cd00116 169 ELNLANNGIgdAGIRalAEGLKANC-NLEVLDLNNNGLTDEGASALaetlASLKSLEVLNLGDNnltdaGAAALASALLS 247
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1052247119 698 IASSLQTLLLSENII----AHMPSGFVSENSSLVTLDLSSNKLK 737
Cdd:cd00116 248 PNISLLTLSLSCNDItddgAKDLAEVLAEKESLLELDLRGNKFG 291
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
868-1012 |
4.03e-09 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 56.60 E-value: 4.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 868 YDAYVSYDTKDasVTDWVINELRFHLEEseeKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTIFVLTRKYARS-WS--- 943
Cdd:pfam01582 1 YDVFLSFRGSD--TREWFVSHLLKELKQ---KGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgWClde 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 944 FKTAFYLALQRlmdeNMDVI--------------------VFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEVLFW 1003
Cdd:pfam01582 76 LVKILECALDL----GQKVIpifyevdpsdvrkqtgsfgkAFKKHKKVLTEEKVLKWRGALNEVANIWHSKSVSDESKFW 151
|
....*....
gi 1052247119 1004 QSLKNVVLT 1012
Cdd:pfam01582 152 KKIAYDISN 160
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
473-736 |
7.15e-09 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 59.86 E-value: 7.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 473 KAIDLSLNNIFFIGQKQFKDFPKIACLNLSSNGNGQALNGSEFSALSHLKYLDFSHNKLDFDADSAFneLPELEVLDLSN 552
Cdd:PLN00113 72 VSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSN 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 553 N----EHYFQIaGVTHRLGF---------------IKNLTKLKVLNVSQNN-----------------IYtLTEYNLSSS 596
Cdd:PLN00113 150 NmlsgEIPNDI-GSFSSLKVldlggnvlvgkipnsLTNLTSLEFLTLASNQlvgqiprelgqmkslkwIY-LGYNNLSGE 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 597 SLKQL--VFSGNRLDVLWKAADKRYMCIFRNLNVLEELDMSFNNLE-RIPKQAFiNLpRNLTKLYLNDNKLRFFNWTLLL 673
Cdd:PLN00113 228 IPYEIggLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SL-QKLISLDLSDNSLSGEIPELVI 305
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1052247119 674 HFPQLQLLDLSRNclyYLTDSLSKIASSLQTL----LLSENIIAHMPSGFVSENsSLVTLDLSSNKL 736
Cdd:PLN00113 306 QLQNLEILHLFSN---NFTGKIPVALTSLPRLqvlqLWSNKFSGEIPKNLGKHN-NLTVLDLSTNNL 368
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
211-288 |
4.11e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 47.90 E-value: 4.11e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1052247119 211 RSLTKLYLSNTNINAVRRADFENLGNLTVLDLSGNCPRcfnapfpcipcpgdasiSIDGNAFDNLTQLEYLNLSSTSL 288
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT-----------------TLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
176-375 |
5.94e-07 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 51.33 E-value: 5.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 176 CNKTFNADGAFEEMANLKELTLSFNNLSRVPrNLP--RSLTKLYLSNTNINavRRADFENLGNLTVLDLSGNCprcfnap 253
Cdd:cd21340 10 NDKNITKIDNLSLCKNLKVLYLYDNKITKIE-NLEflTNLTHLYLQNNQIE--KIENLENLVNLKKLYLGGNR------- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 254 fpcipcpgdasIS-IDGnaFDNLTQLEYLNLS--------------------STSLRKVNSSwFNKMRDLKELHlefnyl 312
Cdd:cd21340 80 -----------ISvVEG--LENLTNLEELHIEnqrlppgekltfdprslaalSNSLRVLNIS-GNNIDSLEPLA------ 139
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1052247119 313 vqeiasgefltKLPSLEILDLSYNYVKtqylEFITLSPNFSKLTCLRSLHLRGY-VFQKLRYKD 375
Cdd:cd21340 140 -----------PLRNLEQLDASNNQIS----DLEELLDLLSSWPSLRELDLTGNpVCKKPKYRD 188
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
730-813 |
6.22e-07 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 53.93 E-value: 6.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 730 DLSSNKLKMINRSTFqtNKNSNLALLRLDGNPFDCTCDMGDFLRWMDENlNVTIPRLTDVTCSSPGDQIGKSIVTLELTT 809
Cdd:TIGR00864 1 DISNNKISTIEEGIC--ANLCNLSEIDLSGNPFECDCGLARLPRWAEEK-GVKVRQPEAALCAGPGALAGQPLLGIPLLD 77
|
....
gi 1052247119 810 CVSD 813
Cdd:TIGR00864 78 SGCD 81
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
54-126 |
2.86e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 45.59 E-value: 2.86e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1052247119 54 VTELDLSDNSITHITNGSFRRLHNLTTINLNRNAMLppyfenyrrnkkgmNITDGAFLNLQKLTELLLENNQL 126
Cdd:pfam13855 3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--------------TLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
54-246 |
8.01e-06 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 48.24 E-value: 8.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 54 VTELDLSDNSITHITNgsFRRLHNLTTINLnrnamlppyFENyrrnkkgmNITD-GAFLNLQKLTELLLENNQLDKIPsG 132
Cdd:cd21340 4 ITHLYLNDKNITKIDN--LSLCKNLKVLYL---------YDN--------KITKiENLEFLTNLTHLYLQNNQIEKIE-N 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 133 LpgslrwlsltqneivsvtknstSGLRNLEILNLGWNCyFGNVCNktfnadgaFEEMANLKELTLSFNNL---------S 203
Cdd:cd21340 64 L----------------------ENLVNLKKLYLGGNR-ISVVEG--------LENLTNLEELHIENQRLppgekltfdP 112
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1052247119 204 RVPRNLPRSLTKLYLSNTNINAVrrADFENLGNLTVLDLSGNC 246
Cdd:cd21340 113 RSLAALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQ 153
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
499-553 |
1.28e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 43.67 E-value: 1.28e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1052247119 499 LNLSSNgNGQALNGSEFSALSHLKYLDFSHNKLDFDADSAFNELPELEVLDLSNN 553
Cdd:pfam13855 6 LDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
760-800 |
7.21e-04 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 38.57 E-value: 7.21e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1052247119 760 NPFDCTCDMGDFLRWmdENLNVTIPRLTDVTCSSPGDQIGK 800
Cdd:smart00082 1 NPFICDCELRWLLRW--LQANEHLQDPVDLRCASPSSLRGP 39
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
700-762 |
2.24e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.12 E-value: 2.24e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1052247119 700 SSLQTLLLSENIIAHMPSGFVSENSSLVTLDLSSNKLKMINRSTFQtnKNSNLALLRLDGNPF 762
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS--GLPSLRYLDLSGNRL 61
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
473-712 |
2.63e-16 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 82.67 E-value: 2.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 473 KAIDLSLNNIFFIGQKQFKDFPKIACLNLSSNgngqalngSEFSALSHLKYLDFSHNKLDfDADSAFNELPELEVLDLSN 552
Cdd:COG4886 75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSN 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 553 NEhyfqiagVTHRLGFIKNLTKLKVLNVSQNNIYTLTEYNLSSSSLKQLVFSGNRLDVLWKAadkrymciFRNLNVLEEL 632
Cdd:COG4886 146 NQ-------LTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP--------LGNLTNLEEL 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 633 DMSFNNLERIPKqAFINLPrNLTKLYLNDNKLRFFNWtlLLHFPQLQLLDLSRNCLYYLTDSLSkiASSLQTLLLSENII 712
Cdd:COG4886 211 DLSGNQLTDLPE-PLANLT-NLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLAN--LTNLKTLDLSNNQL 284
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
154-727 |
2.91e-16 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 84.13 E-value: 2.91e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 154 STSGLRNLEILNLGWNCYFGNVcnktfnADGAFEEMANLKELTLSFNNLS-RVPRNLPRSLTKLYLSNTNINAVRRADFE 232
Cdd:PLN00113 88 AIFRLPYIQTINLSNNQLSGPI------PDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIG 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 233 NLGNLTVLDLSGNCprcfnapfpcipCPGDASISIDgnafdNLTQLEYLNLSSTSLRKVNSSWFNKMRDLKELHLEFNYL 312
Cdd:PLN00113 162 SFSSLKVLDLGGNV------------LVGKIPNSLT-----NLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 313 VQEIASGefLTKLPSLEILDLSYNYVKTQylefitLSPNFSKLTCLRSLHLrgyvFQ-KLRYKDFQPLMNLSKLTTINLG 391
Cdd:PLN00113 225 SGEIPYE--IGGLTSLNHLDLVYNNLTGP------IPSSLGNLKNLQYLFL----YQnKLSGPIPPSIFSLQKLISLDLS 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 392 VNFINQIDFTIFKQPKHLNVIYLSANRISPLVNGTRQSSVRLsaghsHVLKPRSAD------SDFDPHSNFyhstkplik 465
Cdd:PLN00113 293 DNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRL-----QVLQLWSNKfsgeipKNLGKHNNL--------- 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 466 pecvrygKAIDLSLNNIFFIGQKQFKDFPKIACLNLSSNgngqALNGS---EFSALSHLKYLDFSHNKLDFDADSAFNEL 542
Cdd:PLN00113 359 -------TVLDLSTNNLTGEIPEGLCSSGNLFKLILFSN----SLEGEipkSLGACRSLRRVRLQDNSFSGELPSEFTKL 427
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 543 PELEVLDLSNNEhyfqiagVTHRLGFIK-NLTKLKVLNVSQNNIYTLTEYNLSSSSLKQLVFSGNRLDvlwKAADKRymc 621
Cdd:PLN00113 428 PLVYFLDISNNN-------LQGRINSRKwDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFS---GAVPRK--- 494
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 622 iFRNLNVLEELDMSFNNLE-RIPKQafINLPRNLTKLYLNDNKLRFFNWTLLLHFPQLQLLDLSRNCLY-YLTDSLSKIA 699
Cdd:PLN00113 495 -LGSLSELMQLKLSENKLSgEIPDE--LSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVE 571
|
570 580 590
....*....|....*....|....*....|
gi 1052247119 700 SSLQTLLLSENIIAHMPS--GFVSENSSLV 727
Cdd:PLN00113 572 SLVQVNISHNHLHGSLPStgAFLAINASAV 601
|
|
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
868-1004 |
1.32e-15 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 74.67 E-value: 1.32e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 868 YDAYVSYdtkdaSVTDWVINELRFHLEESEEKNVLlCLEERDWDPGLAIIDNLMQSINQSKKTIFVLTRKYARSWSFKTA 947
Cdd:smart00255 2 YDVFISY-----SGKEDVRNEFLSHLLEKLRGYGL-CVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1052247119 948 FYLALQRLMDENMDVIVFILLEP----VLQHSQYLRLRQRIcksSILQWPDNPKAEvlFWQ 1004
Cdd:smart00255 76 LVAALENALEEGGLRVIPIFYEVipsdVRKQPGKFRKVFKK---NYLKWPEDEKEQ--FWK 131
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
36-586 |
1.67e-15 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 81.43 E-value: 1.67e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 36 VVCNNrrlqevpqtvGPDVTELDLSDNSITHITNGSFRRLHNLTTINLNRNAMLPPY------------FENYRRNKKGM 103
Cdd:PLN00113 63 ITCNN----------SSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIpddifttssslrYLNLSNNNFTG 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 104 NITDGAFLNLQKLTellLENNQLD-KIPS--GLPGSLRWLSLTQNEIVSVTKNSTSGLRNLEILNLGWNCYFGNVCNKtf 180
Cdd:PLN00113 133 SIPRGSIPNLETLD---LSNNMLSgEIPNdiGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRE-- 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 181 nadgaFEEMANLKELTLSFNNLS-RVPRNLPR--SLTKLYLSNTNINAVRRADFENLGNLTVLDLSGNCprcFNAPFPci 257
Cdd:PLN00113 208 -----LGQMKSLKWIYLGYNNLSgEIPYEIGGltSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNK---LSGPIP-- 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 258 pcpgdasisidgNAFDNLTQLEYLNLSSTSLRKVNSSWFNKMRDLKELHLEFNYLVQEIASGefLTKLPSLEILDLSYNY 337
Cdd:PLN00113 278 ------------PSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVA--LTSLPRLQVLQLWSNK 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 338 V---------KTQYLEFITLSPNFSKLTCLRSLHLRGYVFQKLRYKDF------QPLMNLSKLTTINLGVNFINQIDFTI 402
Cdd:PLN00113 344 FsgeipknlgKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSlegeipKSLGACRSLRRVRLQDNSFSGELPSE 423
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 403 FKQPKHLNVIYLSANRISPLVNGTRQSSVRLSaghshvLKPRSADSDFDPHSNFYHSTKPlikpecvrygKAIDLSLNNI 482
Cdd:PLN00113 424 FTKLPLVYFLDISNNNLQGRINSRKWDMPSLQ------MLSLARNKFFGGLPDSFGSKRL----------ENLDLSRNQF 487
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 483 FFIGQKQFKDFPKIACLNLSSNgngqALNG---SEFSALSHLKYLDFSHNKLDFDADSAFNELPELEVLDLSNNehyfQI 559
Cdd:PLN00113 488 SGAVPRKLGSLSELMQLKLSEN----KLSGeipDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN----QL 559
|
570 580
....*....|....*....|....*...
gi 1052247119 560 AG-VTHRLGFIKNLTKlkvLNVSQNNIY 586
Cdd:PLN00113 560 SGeIPKNLGNVESLVQ---VNISHNHLH 584
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
111-401 |
2.11e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 79.59 E-value: 2.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 111 LNLQKLTELLLENNQLDKIPSGLPGSLRWLSLTQNEIVSVTKNSTSGLRNLEILNLGWNcyfgnvcnktfnadGAFEEMA 190
Cdd:COG4886 48 LLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN--------------EELSNLT 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 191 NLKELTLSFNNLSRVPRNLPR--SLTKLYLSNTNINAVrRADFENLGNLTVLDLSGNcprcfnapfpcipcpgdaSISID 268
Cdd:COG4886 114 NLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNN------------------QLTDL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 269 GNAFDNLTQLEYLNLSSTSLRKVnSSWFNKMRDLKELHLEFNYLvQEIasGEFLTKLPSLEILDLSYNYVKTQylefitl 348
Cdd:COG4886 175 PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQL-TDL--PEPLANLTNLETLDLSNNQLTDL------- 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1052247119 349 sPNFSKLTCLRSLHLRGyvfqkLRYKDFQPLMNLSKLTTINLGVNFINQIDFT 401
Cdd:COG4886 244 -PELGNLTNLEELDLSN-----NQLTDLPPLANLTNLKTLDLSNNQLTDLKLK 290
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
54-417 |
2.13e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 79.59 E-value: 2.13e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 54 VTELDLSDNSITHITNGSFRRLHNLTTINLNRNAMLPPYFENYRRNKKGMNITDGAFLNLQKLTELLLENNQLDKIPSGL 133
Cdd:COG4886 9 TLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 134 PGSLRWLSLTQNEIVSVTkNSTSGLRNLEILNLGwncyfgnvCNKTFNADGAFEEMANLKELTLSFNNLSRVPRNLPR-- 211
Cdd:COG4886 89 LTDLGDLTNLTELDLSGN-EELSNLTNLESLDLS--------GNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNlt 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 212 SLTKLYLSNTNINAVRRAdFENLGNLTVLDLSGNcprcfnapfpcipcpgdaSISIDGNAFDNLTQLEYLNLSSTSLRKV 291
Cdd:COG4886 160 NLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNN------------------QITDLPEPLGNLTNLEELDLSGNQLTDL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 292 NSSwFNKMRDLKELHLEFNYLvQEIASgefLTKLPSLEILDLSYNYvktqylefITLSPNFSKLTCLRSLHLRGYVFQKL 371
Cdd:COG4886 221 PEP-LANLTNLETLDLSNNQL-TDLPE---LGNLTNLEELDLSNNQ--------LTDLPPLANLTNLKTLDLSNNQLTDL 287
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1052247119 372 RYKDFQPLMNLSKLTTINLGVNFINQIDFTIFKQPKHLNVIYLSAN 417
Cdd:COG4886 288 KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
53-245 |
5.50e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 78.44 E-value: 5.50e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 53 DVTELDLSDNSITHITNgSFRRLHNLTTINLNRNamlppyfenyrrnkkgmNITD--GAFLNLQKLTELLLENNQLDKIP 130
Cdd:COG4886 114 NLESLDLSGNQLTDLPE-ELANLTNLKELDLSNN-----------------QLTDlpEPLGNLTNLKSLDLSNNQLTDLP 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 131 SGLPG--SLRWLSLTQNEIVSVTKnSTSGLRNLEILNLGwncyfgnvCNKTFNADGAFEEMANLKELTLSFNNLSRVPR- 207
Cdd:COG4886 176 EELGNltNLKELDLSNNQITDLPE-PLGNLTNLEELDLS--------GNQLTDLPEPLANLTNLETLDLSNNQLTDLPEl 246
|
170 180 190
....*....|....*....|....*....|....*....
gi 1052247119 208 -NLPrSLTKLYLSNTNINAVrrADFENLGNLTVLDLSGN 245
Cdd:COG4886 247 gNLT-NLEELDLSNNQLTDL--PPLANLTNLKTLDLSNN 282
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
3-412 |
1.68e-14 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 76.90 E-value: 1.68e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 3 LLTSDSCGFSTETNYLRRSFPCDEKIQNGSSVTVVCNNRRLQEVPQTVGPDVTELDLSDNSITHITNGSFRRLHNLTTIN 82
Cdd:COG4886 1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 83 LNRNAMLPPYFENYRRNKKGMNITDGAFL-NLQKLTELLLENNQLDKIPSGLpgslrwlsltqneivsvtknstSGLRNL 161
Cdd:COG4886 81 LLSLLLLGLTDLGDLTNLTELDLSGNEELsNLTNLESLDLSGNQLTDLPEEL----------------------ANLTNL 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 162 EILNLGWNcyfgnvcnKTFNADGAFEEMANLKELTLSFNNLSRVPRNLPR--SLTKLYLSNTNINAVRrADFENLGNLTV 239
Cdd:COG4886 139 KELDLSNN--------QLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNNQITDLP-EPLGNLTNLEE 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 240 LDLSGNcprcfnapfpcipcpgdaSISIDGNAFDNLTQLEYLNLSSTSLRKVnsSWFNKMRDLKELHLEFNylvqEIASG 319
Cdd:COG4886 210 LDLSGN------------------QLTDLPEPLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNN----QLTDL 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 320 EFLTKLPSLEILDLSYNYVKTQYLEFITLSPNFSKLTCLRSLHLRGYVFQKLRYKDFQPLMNLSKLTTINLGVNFINQID 399
Cdd:COG4886 266 PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLS 345
|
410
....*....|...
gi 1052247119 400 FTIFKQPKHLNVI 412
Cdd:COG4886 346 LLALLTLLLLLNL 358
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
54-401 |
2.43e-14 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 76.51 E-value: 2.43e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 54 VTELDLSDNSITHITNGSFRRLHNLTTINLNRNAMLPPYFENYRRNKKGMNITD--GAFLNLQKLTELLLENNQLDKIPS 131
Cdd:COG4886 74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDlpEELANLTNLKELDLSNNQLTDLPE 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 132 GLPG--SLRWLSLTQNEIVSVTKnSTSGLRNLEILNLGwncyfgnvCNKTFNADGAFEEMANLKELTLSFNNLSRVPRNL 209
Cdd:COG4886 154 PLGNltNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLS--------NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPL 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 210 PR--SLTKLYLSNTNINAVrrADFENLGNLTVLDLSGNcprcfnaPFPCIPCPGdasisidgnafdNLTQLEYLNLSSTS 287
Cdd:COG4886 225 ANltNLETLDLSNNQLTDL--PELGNLTNLEELDLSNN-------QLTDLPPLA------------NLTNLKTLDLSNNQ 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 288 LRKVNsswFNKMRDLKELHLEFNYLVQEIASGEFLTKLPSLEILDLSYNYVKTQYLEFITLSPNFSKLTCLRSLHLRGYV 367
Cdd:COG4886 284 LTDLK---LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLS 360
|
330 340 350
....*....|....*....|....*....|....
gi 1052247119 368 FQKLRYKDFQPLMNLSKLTTINLGVNFINQIDFT 401
Cdd:COG4886 361 LLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLL 394
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
493-737 |
1.05e-09 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 61.22 E-value: 1.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 493 FPKIACLNlSSNGNGQALNGSEFSALS-------HLKYLDFSHNKLDFDAD------SAFNELPELEVLDLSNNehYFQI 559
Cdd:cd00116 19 LPKLLCLQ-VLRLEGNTLGEEAAKALAsalrpqpSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDN--ALGP 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 560 AGVthrlGFIKNLTK---LKVLNVSQNNIYTLTEYNL------SSSSLKQLVFSGNRLDVlwkAADKRYMCIFRNLNVLE 630
Cdd:cd00116 96 DGC----GVLESLLRsssLQELKLNNNGLGDRGLRLLakglkdLPPALEKLVLGRNRLEG---ASCEALAKALRANRDLK 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 631 ELDMSFNNL--ERIP--KQAFINLPrNLTKLYLNDNKLRFFNWTLL----LHFPQLQLLDLSRN-----CLYYLTDSLSK 697
Cdd:cd00116 169 ELNLANNGIgdAGIRalAEGLKANC-NLEVLDLNNNGLTDEGASALaetlASLKSLEVLNLGDNnltdaGAAALASALLS 247
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1052247119 698 IASSLQTLLLSENII----AHMPSGFVSENSSLVTLDLSSNKLK 737
Cdd:cd00116 248 PNISLLTLSLSCNDItddgAKDLAEVLAEKESLLELDLRGNKFG 291
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
109-420 |
2.08e-09 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 60.72 E-value: 2.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 109 AFLNLQKLTELLLENNQLDKIPSGLPGSLRWLSLTQNEIVSVTKNSTSGLRNLEILNLGWNCYFGNVCNKTFNADgaFEE 188
Cdd:COG4886 17 LLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD--LGD 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 189 MANLKELTLSFNNLSRVPRNLprslTKLYLSNTNINAVRrADFENLGNLTVLDLSGNcprcfnapfpcipcpgdaSISID 268
Cdd:COG4886 95 LTNLTELDLSGNEELSNLTNL----ESLDLSGNQLTDLP-EELANLTNLKELDLSNN------------------QLTDL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 269 GNAFDNLTQLEYLNLSSTSLRKVnSSWFNKMRDLKELHLEFNYLvQEIasGEFLTKLPSLEILDLSYNYVKTqylefitL 348
Cdd:COG4886 152 PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQI-TDL--PEPLGNLTNLEELDLSGNQLTD-------L 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1052247119 349 SPNFSKLTCLRSLHLRGyvfqklrykdfqplmnlsklttinlgvnfiNQI-DFTIFKQPKHLNVIYLSANRIS 420
Cdd:COG4886 221 PEPLANLTNLETLDLSN------------------------------NQLtDLPELGNLTNLEELDLSNNQLT 263
|
|
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
868-1012 |
4.03e-09 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 56.60 E-value: 4.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 868 YDAYVSYDTKDasVTDWVINELRFHLEEseeKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTIFVLTRKYARS-WS--- 943
Cdd:pfam01582 1 YDVFLSFRGSD--TREWFVSHLLKELKQ---KGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSgWClde 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 944 FKTAFYLALQRlmdeNMDVI--------------------VFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEVLFW 1003
Cdd:pfam01582 76 LVKILECALDL----GQKVIpifyevdpsdvrkqtgsfgkAFKKHKKVLTEEKVLKWRGALNEVANIWHSKSVSDESKFW 151
|
....*....
gi 1052247119 1004 QSLKNVVLT 1012
Cdd:pfam01582 152 KKIAYDISN 160
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
264-710 |
4.78e-09 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 59.56 E-value: 4.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 264 SISIDGNAFDNLTQLEYLNLSSTSLRKVNSSWFNKMRDLKELHLEFNYLVQEIASGEFLTKLPSLEILDLSYNYVKTQYL 343
Cdd:COG4886 4 LLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 344 EFITLSPNFSKLTCLRSLHLRGYvfqklrykdfQPLMNLSKLTTINLGVNFINQIDFTIfKQPKHLNVIYLSANRISPLv 423
Cdd:COG4886 84 LLLLGLTDLGDLTNLTELDLSGN----------EELSNLTNLESLDLSGNQLTDLPEEL-ANLTNLKELDLSNNQLTDL- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 424 ngtrqssvrlsaghshvlkprsaDSDFDPHSNFyhstkplikpecvrygKAIDLSLNNIFFIGqKQFKDFPKIACLNLSS 503
Cdd:COG4886 152 -----------------------PEPLGNLTNL----------------KSLDLSNNQLTDLP-EELGNLTNLKELDLSN 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 504 NGngqaLN--GSEFSALSHLKYLDFSHNKLDfDADSAFNELPELEVLDLSNNehyfQIagvtHRLGFIKNLTKLKVLNVS 581
Cdd:COG4886 192 NQ----ITdlPEPLGNLTNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNN----QL----TDLPELGNLTNLEELDLS 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 582 QNNIYTLTEyNLSSSSLKQLVFSGNRLDVLWKAADKRYMCIFRNLNVLEELDMSFNNLERIPKQAFINLPRNLTKLYLND 661
Cdd:COG4886 259 NNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTL 337
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1052247119 662 NKLRFFNWTLLLHFPQLQLLDLSRNCLYYLTDSLSKIASSLQTLLLSEN 710
Cdd:COG4886 338 TTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLL 386
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
473-736 |
7.15e-09 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 59.86 E-value: 7.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 473 KAIDLSLNNIFFIGQKQFKDFPKIACLNLSSNGNGQALNGSEFSALSHLKYLDFSHNKLDFDADSAFneLPELEVLDLSN 552
Cdd:PLN00113 72 VSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSN 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 553 N----EHYFQIaGVTHRLGF---------------IKNLTKLKVLNVSQNN-----------------IYtLTEYNLSSS 596
Cdd:PLN00113 150 NmlsgEIPNDI-GSFSSLKVldlggnvlvgkipnsLTNLTSLEFLTLASNQlvgqiprelgqmkslkwIY-LGYNNLSGE 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 597 SLKQL--VFSGNRLDVLWKAADKRYMCIFRNLNVLEELDMSFNNLE-RIPKQAFiNLpRNLTKLYLNDNKLRFFNWTLLL 673
Cdd:PLN00113 228 IPYEIggLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SL-QKLISLDLSDNSLSGEIPELVI 305
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1052247119 674 HFPQLQLLDLSRNclyYLTDSLSKIASSLQTL----LLSENIIAHMPSGFVSENsSLVTLDLSSNKL 736
Cdd:PLN00113 306 QLQNLEILHLFSN---NFTGKIPVALTSLPRLqvlqLWSNKFSGEIPKNLGKHN-NLTVLDLSTNNL 368
|
|
| TIR_2 |
pfam13676 |
TIR domain; This is a family of Toll-like receptors. |
871-982 |
8.62e-09 |
|
TIR domain; This is a family of Toll-like receptors.
Pssm-ID: 463954 [Multi-domain] Cd Length: 118 Bit Score: 54.63 E-value: 8.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 871 YVSYDTKDASVTDWVINELrfhleesEEKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTIFVLTRKYARSWSFKTAFYL 950
Cdd:pfam13676 2 FISYAGEDRAWAEWLADAL-------EAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEA 74
|
90 100 110
....*....|....*....|....*....|....*..
gi 1052247119 951 ALQRLMDENmdVIVFILLE-----PVLQHSQYLRLRQ 982
Cdd:pfam13676 75 ALADPEGRK--RLIPVRLEcdlelPGLAGLQYIDLRD 109
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
191-422 |
1.26e-08 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 58.41 E-value: 1.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 191 NLKELTLSFNNLSRVPRNLPRSLTKLYLSNTNINAVRRADFENLGNLTVLDLSGNcprcfnapfpcipcpgdasisidgN 270
Cdd:COG4886 52 LLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------------------------E 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 271 AFDNLTQLEYLNLSSTSLRKVnSSWFNKMRDLKELHLEFNYLvQEIasGEFLTKLPSLEILDLSYNYVKTqylefitLSP 350
Cdd:COG4886 108 ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQL-TDL--PEPLGNLTNLKSLDLSNNQLTD-------LPE 176
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1052247119 351 NFSKLTCLRSLHLRGYVFQKLRykdfQPLMNLSKLTTINLGVNFINQIDFTIfKQPKHLNVIYLSANRISPL 422
Cdd:COG4886 177 ELGNLTNLKELDLSNNQITDLP----EPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDL 243
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
112-294 |
3.47e-07 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 54.32 E-value: 3.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 112 NLQ-KLTELLLENNQLDKIPSGLPGSLRWLSLTQNEIVSVTKNSTSGLRNLEILnlgwncyfgnvCNK-TFNADGAFEEm 189
Cdd:PRK15370 217 NLQgNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSLDLF-----------HNKiSCLPENLPEE- 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 190 anLKELTLSFNNLSRVPRNLPRSLTKLYLSNTNINAVRradfENLG-NLTVLDLSGNCPRCFNAPFP------------- 255
Cdd:PRK15370 285 --LRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALP----ETLPpGLKTLEAGENALTSLPASLPpelqvldvsknqi 358
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1052247119 256 -----CIPcPGDASISIDGNAFDNLTQ-----LEYLNLSSTSLRKVNSS 294
Cdd:PRK15370 359 tvlpeTLP-PTITTLDVSRNALTNLPEnlpaaLQIMQASRNNLVRLPES 406
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
211-288 |
4.11e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 47.90 E-value: 4.11e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1052247119 211 RSLTKLYLSNTNINAVRRADFENLGNLTVLDLSGNCPRcfnapfpcipcpgdasiSIDGNAFDNLTQLEYLNLSSTSL 288
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT-----------------TLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
176-375 |
5.94e-07 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 51.33 E-value: 5.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 176 CNKTFNADGAFEEMANLKELTLSFNNLSRVPrNLP--RSLTKLYLSNTNINavRRADFENLGNLTVLDLSGNCprcfnap 253
Cdd:cd21340 10 NDKNITKIDNLSLCKNLKVLYLYDNKITKIE-NLEflTNLTHLYLQNNQIE--KIENLENLVNLKKLYLGGNR------- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 254 fpcipcpgdasIS-IDGnaFDNLTQLEYLNLS--------------------STSLRKVNSSwFNKMRDLKELHlefnyl 312
Cdd:cd21340 80 -----------ISvVEG--LENLTNLEELHIEnqrlppgekltfdprslaalSNSLRVLNIS-GNNIDSLEPLA------ 139
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1052247119 313 vqeiasgefltKLPSLEILDLSYNYVKtqylEFITLSPNFSKLTCLRSLHLRGY-VFQKLRYKD 375
Cdd:cd21340 140 -----------PLRNLEQLDASNNQIS----DLEELLDLLSSWPSLRELDLTGNpVCKKPKYRD 188
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
730-813 |
6.22e-07 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 53.93 E-value: 6.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 730 DLSSNKLKMINRSTFqtNKNSNLALLRLDGNPFDCTCDMGDFLRWMDENlNVTIPRLTDVTCSSPGDQIGKSIVTLELTT 809
Cdd:TIGR00864 1 DISNNKISTIEEGIC--ANLCNLSEIDLSGNPFECDCGLARLPRWAEEK-GVKVRQPEAALCAGPGALAGQPLLGIPLLD 77
|
....
gi 1052247119 810 CVSD 813
Cdd:TIGR00864 78 SGCD 81
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
208-707 |
2.11e-06 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 51.47 E-value: 2.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 208 NLPRSLTKLYLSNTNINAVRRADFENLGNLTVLDLSGNCPRCFNAPFPCIPCPGDASISIDGNAFDNLTQLEYLNLSSTS 287
Cdd:COG4886 4 LLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 288 LRKVNSSWFNKMRDLKELHLEFNylvqeiasgEFLTKLPSLEILDLSYNYVKTqylefitLSPNFSKLTCLRSLHLRGYV 367
Cdd:COG4886 84 LLLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESLDLSGNQLTD-------LPEELANLTNLKELDLSNNQ 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 368 FQKLRykdfQPLMNLSKLTTINLGVNFINQIDFTIFKQPKhLNVIYLSANRISPLvngtrqssvrlsaghshvlkprsad 447
Cdd:COG4886 148 LTDLP----EPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQITDL------------------------- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 448 sdfdphsnfyhstkplikpecvrygkaidlslnniffigQKQFKDFPKIACLNLSSNGNGQAlnGSEFSALSHLKYLDFS 527
Cdd:COG4886 198 ---------------------------------------PEPLGNLTNLEELDLSGNQLTDL--PEPLANLTNLETLDLS 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 528 HNKL-DFdadSAFNELPELEVLDLSNNehyfQIAGvthrLGFIKNLTKLKVLNVSQNNIYTLTEYNLSSSSLKQLVFSGN 606
Cdd:COG4886 237 NNQLtDL---PELGNLTNLEELDLSNN----QLTD----LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 607 RLDVLWKAADKrymciFRNLNVLEELDMSFNNLERIPKQAFINLPRNLTKLYLNDNKLRFFNWTLLLHFPQLQLLDLSRN 686
Cdd:COG4886 306 LLLNLLELLIL-----LLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLL 380
|
490 500
....*....|....*....|.
gi 1052247119 687 CLYYLTDSLSKIASSLQTLLL 707
Cdd:COG4886 381 TLALLLLTLLLLLLTTTAGVL 401
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
54-126 |
2.86e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 45.59 E-value: 2.86e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1052247119 54 VTELDLSDNSITHITNGSFRRLHNLTTINLNRNAMLppyfenyrrnkkgmNITDGAFLNLQKLTELLLENNQL 126
Cdd:pfam13855 3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--------------TLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
54-246 |
8.01e-06 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 48.24 E-value: 8.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 54 VTELDLSDNSITHITNgsFRRLHNLTTINLnrnamlppyFENyrrnkkgmNITD-GAFLNLQKLTELLLENNQLDKIPsG 132
Cdd:cd21340 4 ITHLYLNDKNITKIDN--LSLCKNLKVLYL---------YDN--------KITKiENLEFLTNLTHLYLQNNQIEKIE-N 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 133 LpgslrwlsltqneivsvtknstSGLRNLEILNLGWNCyFGNVCNktfnadgaFEEMANLKELTLSFNNL---------S 203
Cdd:cd21340 64 L----------------------ENLVNLKKLYLGGNR-ISVVEG--------LENLTNLEELHIENQRLppgekltfdP 112
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1052247119 204 RVPRNLPRSLTKLYLSNTNINAVrrADFENLGNLTVLDLSGNC 246
Cdd:cd21340 113 RSLAALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQ 153
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
499-553 |
1.28e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 43.67 E-value: 1.28e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1052247119 499 LNLSSNgNGQALNGSEFSALSHLKYLDFSHNKLDFDADSAFNELPELEVLDLSNN 553
Cdd:pfam13855 6 LDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
55-207 |
1.41e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 47.47 E-value: 1.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 55 TELDLSDNSITHITNgsFRRLHNLTTINLNRN--AMLppyfenyrrnkKGMNitdgaflNLQKLTELLLENNQLDK---- 128
Cdd:cd21340 49 THLYLQNNQIEKIEN--LENLVNLKKLYLGGNriSVV-----------EGLE-------NLTNLEELHIENQRLPPgekl 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 129 -----IPSGLPGSLRWLSLTQNEIVSVTknSTSGLRNLEILNLGWNC--YFGNVCNktfnadgAFEEMANLKELTLSFNN 201
Cdd:cd21340 109 tfdprSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQisDLEELLD-------LLSSWPSLRELDLTGNP 179
|
....*.
gi 1052247119 202 LSRVPR 207
Cdd:cd21340 180 VCKKPK 185
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
276-336 |
1.71e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 43.28 E-value: 1.71e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1052247119 276 TQLEYLNLSSTSLRKVNSSWFNKMRDLKELHLEFNYLvQEIASGEFlTKLPSLEILDLSYN 336
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSPGAF-SGLPSLRYLDLSGN 59
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
637-739 |
3.40e-05 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 47.77 E-value: 3.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 637 NNLERIPKqafiNLPRNLTKLYLNDNKLRFFNWTLllhfPQ-LQLLDLSRNCLYYLTDSLSkiaSSLQTLLLSENIIAHM 715
Cdd:PRK15370 209 NELKSLPE----NLQGNIKTLYANSNQLTSIPATL----PDtIQEMELSINRITELPERLP---SALQSLDLFHNKISCL 277
|
90 100
....*....|....*....|....
gi 1052247119 716 PSGFVSEnssLVTLDLSSNKLKMI 739
Cdd:PRK15370 278 PENLPEE---LRYLSVYDNSIRTL 298
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
596-664 |
4.60e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 42.13 E-value: 4.60e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1052247119 596 SSLKQLVFSGNRLDVLWKAAdkrymciFRNLNVLEELDMSFNNLERIPKQAFINLPrNLTKLYLNDNKL 664
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGA-------FKGLSNLKVLDLSNNLLTTLSPGAFSGLP-SLRYLDLSGNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
55-246 |
1.09e-04 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 45.42 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 55 TELDLSDNSITHITNGSFRRLHNLTTI---NLNRNAMlppyfenyrrNKKGMNITDGAFLNLQ-KLTELLLENNQL---- 126
Cdd:cd00116 84 QELDLSDNALGPDGCGVLESLLRSSSLqelKLNNNGL----------GDRGLRLLAKGLKDLPpALEKLVLGRNRLegas 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 127 -DKIPSGLP--GSLRWLSLTQNEI----VSVTKNSTSGLRNLEILNLgWNCYFGNVCNKTFNadGAFEEMANLKELTLSF 199
Cdd:cd00116 154 cEALAKALRanRDLKELNLANNGIgdagIRALAEGLKANCNLEVLDL-NNNGLTDEGASALA--ETLASLKSLEVLNLGD 230
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 200 NNLSRVP--------RNLPRSLTKLYLSNTNINA-----VRRADFENLgNLTVLDLSGNC 246
Cdd:cd00116 231 NNLTDAGaaalasalLSPNISLLTLSLSCNDITDdgakdLAEVLAEKE-SLLELDLRGNK 289
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
114-169 |
1.72e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 40.59 E-value: 1.72e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 114 QKLTELLLENNQLDKIP----SGLPgSLRWLSLTQNEIVSVTKNSTSGLRNLEILNLGWN 169
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDdgafKGLS-NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
629-762 |
3.13e-04 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 43.24 E-value: 3.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 629 LEELDMSFNNLERIPkqaFINLPRNLTKLYLNDNKLRffnwTL--LLHFPQLQLLDLSR------NCLYYLTDSLSKIAS 700
Cdd:cd21340 48 LTHLYLQNNQIEKIE---NLENLVNLKKLYLGGNRIS----VVegLENLTNLEELHIENqrlppgEKLTFDPRSLAALSN 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1052247119 701 SLQTLLLSENIIAHMpSGFVSEnSSLVTLDLSSNKLKMINRSTFQTNKNSNLALLRLDGNPF 762
Cdd:cd21340 121 SLRVLNISGNNIDSL-EPLAPL-RNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPV 180
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
212-413 |
3.47e-04 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 44.40 E-value: 3.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 212 SLTKLYLSNTNINAvrrADFENLG-------NLTVLDLSGNCprcfnapfpcIPCPGDASISidgNAFDNLTQLEYLNLS 284
Cdd:COG5238 237 SLTTLDLSNNQIGD---EGVIALAealknntTVETLYLSGNQ----------IGAEGAIALA---KALQGNTTLTSLDLS 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 285 STSLRkvNSSWFN------KMRDLKELHLEFNYLVQE--IASGEFLTKLPSLEILDLSYNYVKTQYLEFITLSPNfsKLT 356
Cdd:COG5238 301 VNRIG--DEGAIAlaeglqGNKTLHTLNLAYNGIGAQgaIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLE--GNT 376
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1052247119 357 CLRSLHLRGYVFQKLRYKDFQPLMNLSKLTTINLGVNFI-NQIDFTIFKQPKHLNVIY 413
Cdd:COG5238 377 TLRELNLGKNNIGKQGAEALIDALQTNRLHTLILDGNLIgAEAQQRLEQLLERIKSVY 434
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
36-86 |
3.52e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 39.43 E-value: 3.52e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1052247119 36 VVCNNRrLQEVPQTV---GPDVTELDLSDNSITHITNGSFRRLHNLTTINLNRN 86
Cdd:pfam13855 7 DLSNNR-LTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
266-312 |
6.48e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 38.66 E-value: 6.48e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1052247119 266 SIDGNAFDNLTQLEYLNLSSTSLRKVNSSWFNKMRDLKELHLEFNYL 312
Cdd:pfam13855 15 SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
760-800 |
7.21e-04 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 38.57 E-value: 7.21e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1052247119 760 NPFDCTCDMGDFLRWmdENLNVTIPRLTDVTCSSPGDQIGK 800
Cdd:smart00082 1 NPFICDCELRWLLRW--LQANEHLQDPVDLRCASPSSLRGP 39
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
345-553 |
7.47e-04 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 42.08 E-value: 7.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 345 FITLSPNFSKLTCLRSLHLRGYVFQKLrykdfQPLMNLSKLTTINLGVNFINQIDFtiFKQPKHLNVIYLSANRISPLVN 424
Cdd:cd21340 13 NITKIDNLSLCKNLKVLYLYDNKITKI-----ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 425 GTRQSSVRlsagHSHVLKPRSADSD---FDPHSNFYHStkplikpECVRYgkaidlslnniffigqkqfkdfpkiacLNL 501
Cdd:cd21340 86 LENLTNLE----ELHIENQRLPPGEkltFDPRSLAALS-------NSLRV---------------------------LNI 127
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1052247119 502 SSNGNGqalNGSEFSALSHLKYLDFSHNKL-DFDA-DSAFNELPELEVLDLSNN 553
Cdd:cd21340 128 SGNNID---SLEPLAPLRNLEQLDASNNQIsDLEElLDLLSSWPSLRELDLTGN 178
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
136-202 |
9.61e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 38.27 E-value: 9.61e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1052247119 136 SLRWLSLTQNEIVSVTKNSTSGLRNLEILNLGWNcyfgnvcNKTFNADGAFEEMANLKELTLSFNNL 202
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN-------LLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
652-710 |
1.53e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.89 E-value: 1.53e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1052247119 652 RNLTKLYLNDNKLRFFNWTLLLHFPQLQLLDLSRNCLyyltDSLSKIA----SSLQTLLLSEN 710
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL----TTLSPGAfsglPSLRYLDLSGN 59
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
519-585 |
1.54e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.89 E-value: 1.54e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1052247119 519 SHLKYLDFSHNKLDFDADSAFNELPELEVLDLSNN--EHYFQIAgvthrlgfIKNLTKLKVLNVSQNNI 585
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNllTTLSPGA--------FSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
302-365 |
1.79e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.50 E-value: 1.79e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1052247119 302 LKELHLEFNYLVQeiASGEFLTKLPSLEILDLSYNYVKtqylefiTLSPN-FSKLTCLRSLHLRG 365
Cdd:pfam13855 3 LRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLT-------TLSPGaFSGLPSLRYLDLSG 58
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
700-762 |
2.24e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.12 E-value: 2.24e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1052247119 700 SSLQTLLLSENIIAHMPSGFVSENSSLVTLDLSSNKLKMINRSTFQtnKNSNLALLRLDGNPF 762
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS--GLPSLRYLDLSGNRL 61
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
255-365 |
2.70e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 41.73 E-value: 2.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 255 PCIP---------CPGDASIS---IDGnafdnltqleyLNLSSTSLRKVNSSWFNKMRDLKELHLEFNYLVQEIASGefL 322
Cdd:PLN03150 396 PCVPqqhpwsgadCQFDSTKGkwfIDG-----------LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPS--L 462
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1052247119 323 TKLPSLEILDLSYNyvktqylEFITLSP-NFSKLTCLRSLHLRG 365
Cdd:PLN03150 463 GSITSLEVLDLSYN-------SFNGSIPeSLGQLTSLRILNLNG 499
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
517-601 |
2.88e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.15 E-value: 2.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 517 ALSH-LKYLDFSHNKLDFDADsaFNELPELEVLDLSNNehyfQIAGVTHRLGFIKNLTKLKVLNVSQNNIYTLTEYN--- 592
Cdd:cd21340 117 ALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNN----QISDLEELLDLLSSWPSLRELDLTGNPVCKKPKYRdki 190
|
90
....*....|
gi 1052247119 593 -LSSSSLKQL 601
Cdd:cd21340 191 iLASKSLEVL 200
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
506-583 |
7.53e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 40.18 E-value: 7.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1052247119 506 NGQALNG---SEFSALSHLKYLDFSHNKLDFDADSAFNELPELEVLDLSNNEhyfqIAG-VTHRLGfikNLTKLKVLNVS 581
Cdd:PLN03150 426 DNQGLRGfipNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNS----FNGsIPESLG---QLTSLRILNLN 498
|
..
gi 1052247119 582 QN 583
Cdd:PLN03150 499 GN 500
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
159-223 |
7.90e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 35.58 E-value: 7.90e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1052247119 159 RNLEILNLgWNCYFGNVCnktfnaDGAFEEMANLKELTLSFNNLSRVPRNL---PRSLTKLYLSNTNI 223
Cdd:pfam13855 1 PNLRSLDL-SNNRLTSLD------DGAFKGLSNLKVLDLSNNLLTTLSPGAfsgLPSLRYLDLSGNRL 61
|
|
| |
