|
Name |
Accession |
Description |
Interval |
E-value |
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
211-985 |
0e+00 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 1348.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 211 KKIAIITSGGDAPGMNAAVRAVTRAGIFYGCKVYACYEGYTGLVKGGDMLKELQWQDVRGLLSIGGTIIGTARSKEFRER 290
Cdd:TIGR02478 1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 291 WGRLQACYNMVSNGIDALVVCGGDGSLTGADLFRNEWPELIKELLGEGKITKEQYETHRNLTIVGLVGSIDNDMCGTDST 370
Cdd:TIGR02478 81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 371 IGAYSSLERIIELVDYIDATAASHSRAFVVEVMGRHCGWLGLMSGIATGADYIFIPERPPSEtNWKDDLKKVCLRHREKG 450
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEE-GWEDQLCHKLKRNRKAG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 451 RRKTTVIVAEGAIDDQLNPITSEEVKDVLVE-IGLDTRITRLGHVQRGGAPCAFDRFLATVQGVDAVRAVLESTPAIPSP 529
Cdd:TIGR02478 240 KRKTIVIVAEGAIDRDLNPITSEDVKDVLVErLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSP 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 530 VISILENKIVRQPLVESVAQTKTVSDAIEAKDFDKALKLRDQEFATSYESFLSVSKYDDGSYLVP-ESSRLNIAIIHVGA 608
Cdd:TIGR02478 320 VISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPsEASRLRIAIIHVGA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 609 PTSALNPATRVATLNSLAKGHRVFAIRNGFAGLIRHGaVRELNWIDVEDWHNTGGSEIGTNRSLPSDDMGTVAYYFQQYK 688
Cdd:TIGR02478 400 PAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHD-VRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHK 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 689 FDGLIIIGGFEAFTALYQLDAARAQYPIFNIPMCCLPATVSNNVPGTEYSLGSDTCLNTLSGYCDAVKQSASASRRRTFV 768
Cdd:TIGR02478 479 IDGLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFV 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 769 VEVQGGYSGYLASYAGLITGALAVYTPENPINLQTVQEDIELLTRTYEEDdgknRSGKIFIHNEKASKVYTTDLIAAIIG 848
Cdd:TIGR02478 559 VETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEG----RAGKLILRNEKASKVYTTDFIARIIS 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 849 EAGKGRFESRTAVPGHVQQGKSPSSIDRVNACRLAIKCCNFIEDANFQVKHNANLSADERhlrffyddgvktsavsgkss 928
Cdd:TIGR02478 635 EEGKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSADDT-------------------- 694
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*..
gi 1051425808 929 viddnTSVVIGIQGSEVTFTPVKQLWEKETHHKWRKGKNVHWEQLNIVSDLLSGRLS 985
Cdd:TIGR02478 695 -----SAVVIGIRGSNVLFTPVKQLLANETDFEHRRPKNQWWLQLRPLVRILAGRDS 746
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
210-971 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 1070.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 210 KKKIAIITSGGDAPGMNAAVRAVTRAGIFYGCKVYACYEGYTGLVKGGDMLKELQWQDVRGLLSIGGTIIGTARSKEFRE 289
Cdd:cd00764 3 GKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEFRE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 290 RWGRLQACYNMVSNGIDALVVCGGDGSLTGADLFRNEWPELIKELLGEGKITKEQYETHRNLTIVGLVGSIDNDMCGTDS 369
Cdd:cd00764 83 REGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGTDM 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 370 TIGAYSSLERIIELVDYIDATAASHSRAFVVEVMGRHCGWLGLMSGIATGADYIFIPERPPSEtNWKDDLKKVCLRHREK 449
Cdd:cd00764 163 TIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPED-GWEDQMCRRLSEHRSR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 450 GRRKTTVIVAEGAIDDQLNPITSEEVKDVLVE-IGLDTRITRLGHVQRGGAPCAFDRFLATVQGVDAVRAVLESTPAIPS 528
Cdd:cd00764 242 GKRLNIIIVAEGAIDDQLKPITSEDVKDLVVErLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTPA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 529 PVISILENKIVRQPLVESVAQTKTVSDAIEAKDFDKALKLRDQEFATSYESF--LSVSKYDDgsylVPESSRLNIAIIHV 606
Cdd:cd00764 322 CVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYklLAIELPQP----LPEKTNLNIAIVNV 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 607 GAPTSALNPATRVATLNSLAKGHRVFAIRNGFAGLIRHGAVrELNWIDVEDWHNTGGSEIGTNRSLPSDDMGTVAYYFQQ 686
Cdd:cd00764 398 GAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIV-ELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQK 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 687 YKFDGLIIIGGFEAFTALYQLDAARAQYPIFNIPMCCLPATVSNNVPGTEYSLGSDTCLNTLSGYCDAVKQSASASRRRT 766
Cdd:cd00764 477 YGIDGLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRV 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 767 FVVEVQGGYSGYLASYAGLITGALAVYTPENPINLQTVQEDIELLTRTYEEDDGKNRSGKIFIHNEKASKVYTTDLIAai 846
Cdd:cd00764 557 FIVETMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYS-- 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 847 igEAGKGRFESRTAVPGHVQQGKSPSSIDRVNACRLAIKCCNFIEDANFQVKHNANLSADErhLRFFYDDGVKTSAVSGK 926
Cdd:cd00764 635 --EEGKGVFDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFAND--PDFNCVNGVKKYAVLFE 710
|
730 740 750 760
....*....|....*....|....*....|....*....|....*
gi 1051425808 927 SSVIDDNTSVVIGIQgSEVTFTPVKQLWEKETHHKWRKGKNVHWE 971
Cdd:cd00764 711 PVEELKQTTFEHRIP-KEQWWLSLRPLLKILAKYKISADISDHGQ 754
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
212-517 |
2.05e-137 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 412.89 E-value: 2.05e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 212 KIAIITSGGDAPGMNAAVRAVTRAGIFYGCKVYACYEGYTGLVKGgdMLKELQWQDVRGLLSIGGTIIGTARSKEFRERW 291
Cdd:pfam00365 1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEG--DIDELTWRDVSGILNRGGTILGTSRSKPFKTEE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 292 GRLQACYNMVSNGIDALVVCGGDGSLTGADLFRNEWpelikellgegkitkeqyethrNLTIVGLVGSIDNDMCGTDSTI 371
Cdd:pfam00365 79 GREKIAENLKKLGIDALVVIGGDGSLTGANKLSEER----------------------GIPVVGIPKTIDNDIPGTDYTI 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 372 GAYSSLERIIELVDYIDATAASHSRAFVVEVMGRHCGWLGLMSGIATGADYIFIPERPPsetnwkdDLKKVC--LRHREK 449
Cdd:pfam00365 137 GFDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPF-------DIEELCekIKELRK 209
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1051425808 450 GRRKTTVIVAEGAIDdqlnpitSEEVKDVLVE-IGLDTRITRLGHVQRGGAPCAFDRFLATVQGVDAVR 517
Cdd:pfam00365 210 GKRFSIIVVAEGASD-------GEFLAKLIEEgTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
211-555 |
1.92e-113 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 352.08 E-value: 1.92e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 211 KKIAIITSGGDAPGMNAAVRAVTRAGIFYGCKVYACYEGYTGLVKGgDMLKeLQWQDVRGLLSIGGTIIGTARSKEFRER 290
Cdd:PRK03202 2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG-DIVK-LDLKSVSDIINRGGTILGSARFPEFKDE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 291 WGRLQACYNMVSNGIDALVVCGGDGSLTGADLFrnewpelikellgegkitkeqyeTHRNLTIVGLVGSIDNDMCGTDST 370
Cdd:PRK03202 80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAKRL-----------------------TEHGIPVIGLPGTIDNDIAGTDYT 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 371 IGAYSSLERIIELVDYIDATAASHSRAFVVEVMGRHCGWLGLMSGIATGADYIFIPERPPSetnwKDDLKKVCLRHREKG 450
Cdd:PRK03202 137 IGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFD----IEELCAKIKKGRERG 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 451 RRKTTVIVAEGAID-DQLnpitSEEVKDvlvEIGLDTRITRLGHVQRGGAPCAFDRFLATVQGVDAVRAVLESTPAIpsp 529
Cdd:PRK03202 213 KKHAIIVVAEGVMPaEEL----AKEIEE---RTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGR--- 282
|
330 340
....*....|....*....|....*.
gi 1051425808 530 VISILENKIVRQPLVESVAQTKTVSD 555
Cdd:PRK03202 283 MVGIQNNKIVHVPIEEAVENMKHPFD 308
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
210-556 |
6.40e-113 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 351.68 E-value: 6.40e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 210 KKKIAIITSGGDAPGMNAAVRAVTRAGIFYGCKVYACYEGYTGLVKGGdmLKELQWQDVRGLLSIGGTIIGTARSKEFRE 289
Cdd:COG0205 1 MKRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGD--IIDLTREDVSGILQRGGTILGSSRSKPFKT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 290 RWGRLQACYNMVSNGIDALVVCGGDGSLTGADLFRNEWPelikellgegkitkeqyethrnLTIVGLVGSIDNDMCGTDS 369
Cdd:COG0205 79 EEGREKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG----------------------IPVVGIPKTIDNDLPGTDY 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 370 TIGAYSSLERIIELVDYIDATAASHSRAFVVEVMGRHCGWLGLMSGIATGADYIFIPERPPSEtnwkDDLKKVCLRHREK 449
Cdd:COG0205 137 TIGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDL----DKLLEKLKERRKR 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 450 GRRKTTVIVAEGAIDDQLNPI---------------TSEEVKDVLVE-IGLDTRITRLGHVQRGGAPCAFDRFLATVQGV 513
Cdd:COG0205 213 GKGYSIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEErTGIETRVTVLGHLQRGGSPSAFDRVLASRLGA 292
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1051425808 514 DAVRAVLESTPAIpspVISILENKIVRQPLVESVAQTKTVSDA 556
Cdd:COG0205 293 AAVELLLEGKTGV---MVGIRRGEIVLVPLEEVANKEKPVDPD 332
|
|
| Pfk_N |
pfam18468 |
Phosphofructokinase N-terminal domain yeast; This is a phosphofructokinase (Pfk) N-terminal ... |
7-112 |
6.93e-50 |
|
Phosphofructokinase N-terminal domain yeast; This is a phosphofructokinase (Pfk) N-terminal domain found in yeast ATP-dependent 6-phosphofructokinase subunit alpha. ATP-dependent 6-phosphofructokinases (Pfks, EC 2.7.1.11) catalyze the phosphorylation of fructose 6-phosphate (F-6-P) to fructose 1,6-bisphosphate, a key control step of glycolysis in most organizms. The N-terminal domain contains the active site and is related to glyoxalase I (E.C. 4.4.1.5).
Pssm-ID: 408261 Cd Length: 98 Bit Score: 171.17 E-value: 6.93e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 7 SALSFTSFVTNDDKLFEETFNFYTKLGFHATRSYVKDNRSDFELTGISTDSIKEIWLESFPLSEVveTSAGRelRKPLQE 86
Cdd:pfam18468 1 SGLSFISFVTNDPDKFEATIKFYTKLGFSATKSYSKDTNNDFELIGVSTDSIKEIWLESFPLSEV--DSHGF--RIPWQE 76
|
90 100
....*....|....*....|....*.
gi 1051425808 87 SVGYQSeallGYSPYQSDGVVIKLRL 112
Cdd:pfam18468 77 SPGYQG----DYSPKLSDGVVIKLRL 98
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
211-985 |
0e+00 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 1348.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 211 KKIAIITSGGDAPGMNAAVRAVTRAGIFYGCKVYACYEGYTGLVKGGDMLKELQWQDVRGLLSIGGTIIGTARSKEFRER 290
Cdd:TIGR02478 1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 291 WGRLQACYNMVSNGIDALVVCGGDGSLTGADLFRNEWPELIKELLGEGKITKEQYETHRNLTIVGLVGSIDNDMCGTDST 370
Cdd:TIGR02478 81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 371 IGAYSSLERIIELVDYIDATAASHSRAFVVEVMGRHCGWLGLMSGIATGADYIFIPERPPSEtNWKDDLKKVCLRHREKG 450
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEE-GWEDQLCHKLKRNRKAG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 451 RRKTTVIVAEGAIDDQLNPITSEEVKDVLVE-IGLDTRITRLGHVQRGGAPCAFDRFLATVQGVDAVRAVLESTPAIPSP 529
Cdd:TIGR02478 240 KRKTIVIVAEGAIDRDLNPITSEDVKDVLVErLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSP 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 530 VISILENKIVRQPLVESVAQTKTVSDAIEAKDFDKALKLRDQEFATSYESFLSVSKYDDGSYLVP-ESSRLNIAIIHVGA 608
Cdd:TIGR02478 320 VISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPsEASRLRIAIIHVGA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 609 PTSALNPATRVATLNSLAKGHRVFAIRNGFAGLIRHGaVRELNWIDVEDWHNTGGSEIGTNRSLPSDDMGTVAYYFQQYK 688
Cdd:TIGR02478 400 PAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHD-VRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHK 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 689 FDGLIIIGGFEAFTALYQLDAARAQYPIFNIPMCCLPATVSNNVPGTEYSLGSDTCLNTLSGYCDAVKQSASASRRRTFV 768
Cdd:TIGR02478 479 IDGLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFV 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 769 VEVQGGYSGYLASYAGLITGALAVYTPENPINLQTVQEDIELLTRTYEEDdgknRSGKIFIHNEKASKVYTTDLIAAIIG 848
Cdd:TIGR02478 559 VETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEG----RAGKLILRNEKASKVYTTDFIARIIS 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 849 EAGKGRFESRTAVPGHVQQGKSPSSIDRVNACRLAIKCCNFIEDANFQVKHNANLSADERhlrffyddgvktsavsgkss 928
Cdd:TIGR02478 635 EEGKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSADDT-------------------- 694
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*..
gi 1051425808 929 viddnTSVVIGIQGSEVTFTPVKQLWEKETHHKWRKGKNVHWEQLNIVSDLLSGRLS 985
Cdd:TIGR02478 695 -----SAVVIGIRGSNVLFTPVKQLLANETDFEHRRPKNQWWLQLRPLVRILAGRDS 746
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
210-971 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 1070.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 210 KKKIAIITSGGDAPGMNAAVRAVTRAGIFYGCKVYACYEGYTGLVKGGDMLKELQWQDVRGLLSIGGTIIGTARSKEFRE 289
Cdd:cd00764 3 GKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEFRE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 290 RWGRLQACYNMVSNGIDALVVCGGDGSLTGADLFRNEWPELIKELLGEGKITKEQYETHRNLTIVGLVGSIDNDMCGTDS 369
Cdd:cd00764 83 REGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGTDM 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 370 TIGAYSSLERIIELVDYIDATAASHSRAFVVEVMGRHCGWLGLMSGIATGADYIFIPERPPSEtNWKDDLKKVCLRHREK 449
Cdd:cd00764 163 TIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPED-GWEDQMCRRLSEHRSR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 450 GRRKTTVIVAEGAIDDQLNPITSEEVKDVLVE-IGLDTRITRLGHVQRGGAPCAFDRFLATVQGVDAVRAVLESTPAIPS 528
Cdd:cd00764 242 GKRLNIIIVAEGAIDDQLKPITSEDVKDLVVErLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTPA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 529 PVISILENKIVRQPLVESVAQTKTVSDAIEAKDFDKALKLRDQEFATSYESF--LSVSKYDDgsylVPESSRLNIAIIHV 606
Cdd:cd00764 322 CVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYklLAIELPQP----LPEKTNLNIAIVNV 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 607 GAPTSALNPATRVATLNSLAKGHRVFAIRNGFAGLIRHGAVrELNWIDVEDWHNTGGSEIGTNRSLPSDDMGTVAYYFQQ 686
Cdd:cd00764 398 GAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIV-ELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQK 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 687 YKFDGLIIIGGFEAFTALYQLDAARAQYPIFNIPMCCLPATVSNNVPGTEYSLGSDTCLNTLSGYCDAVKQSASASRRRT 766
Cdd:cd00764 477 YGIDGLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRV 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 767 FVVEVQGGYSGYLASYAGLITGALAVYTPENPINLQTVQEDIELLTRTYEEDDGKNRSGKIFIHNEKASKVYTTDLIAai 846
Cdd:cd00764 557 FIVETMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYS-- 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 847 igEAGKGRFESRTAVPGHVQQGKSPSSIDRVNACRLAIKCCNFIEDANFQVKHNANLSADErhLRFFYDDGVKTSAVSGK 926
Cdd:cd00764 635 --EEGKGVFDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFAND--PDFNCVNGVKKYAVLFE 710
|
730 740 750 760
....*....|....*....|....*....|....*....|....*
gi 1051425808 927 SSVIDDNTSVVIGIQgSEVTFTPVKQLWEKETHHKWRKGKNVHWE 971
Cdd:cd00764 711 PVEELKQTTFEHRIP-KEQWWLSLRPLLKILAKYKISADISDHGQ 754
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
211-567 |
3.73e-159 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 471.78 E-value: 3.73e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 211 KKIAIITSGGDAPGMNAAVRAVTRAGIFYGCKVYACYEGYTGLVKGGdmLKELQWQDVRGLLSIGGTIIGTARSKEFRER 290
Cdd:cd00363 1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGD--IKELDWESVSDIINRGGTIIGSARCKEFRTE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 291 WGRLQACYNMVSNGIDALVVCGGDGSLTGADLFRNEWPElikellgegkitkeqyeTHRNLTIVGLVGSIDNDMCGTDST 370
Cdd:cd00363 79 EGRAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPS-----------------KYQGFNVIGLPGTIDNDIKGTDYT 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 371 IGAYSSLERIIELVDYIDATAASHSRAFVVEVMGRHCGWLGLMSGIATGADYIFIPERPPSEtNWKDDLKKVCLRHREKG 450
Cdd:cd00363 142 IGFDTALKTIVEAIDRIRDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAAD-EWEEEMVDVIKKRRERG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 451 RRKTTVIVAEGAIDDQLNPITSEEVKDVLVE-IGLDTRITRLGHVQRGGAPCAFDRFLATVQGVDAVRAVLESTPAIPSP 529
Cdd:cd00363 221 KRHGIVIVAEGAIDFIPKPITEKLLAKLVEErLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGTPVG 300
|
330 340 350
....*....|....*....|....*....|....*...
gi 1051425808 530 VISILENKIVRQPLVESVAQTKTVSDAIEAKDFDKALK 567
Cdd:cd00363 301 IQNLNENQVVRHPLTEAVNMTKRVGVDLEGRPFKKFAK 338
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
212-517 |
2.05e-137 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 412.89 E-value: 2.05e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 212 KIAIITSGGDAPGMNAAVRAVTRAGIFYGCKVYACYEGYTGLVKGgdMLKELQWQDVRGLLSIGGTIIGTARSKEFRERW 291
Cdd:pfam00365 1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEG--DIDELTWRDVSGILNRGGTILGTSRSKPFKTEE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 292 GRLQACYNMVSNGIDALVVCGGDGSLTGADLFRNEWpelikellgegkitkeqyethrNLTIVGLVGSIDNDMCGTDSTI 371
Cdd:pfam00365 79 GREKIAENLKKLGIDALVVIGGDGSLTGANKLSEER----------------------GIPVVGIPKTIDNDIPGTDYTI 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 372 GAYSSLERIIELVDYIDATAASHSRAFVVEVMGRHCGWLGLMSGIATGADYIFIPERPPsetnwkdDLKKVC--LRHREK 449
Cdd:pfam00365 137 GFDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPF-------DIEELCekIKELRK 209
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1051425808 450 GRRKTTVIVAEGAIDdqlnpitSEEVKDVLVE-IGLDTRITRLGHVQRGGAPCAFDRFLATVQGVDAVR 517
Cdd:pfam00365 210 GKRFSIIVVAEGASD-------GEFLAKLIEEgTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
211-555 |
1.92e-113 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 352.08 E-value: 1.92e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 211 KKIAIITSGGDAPGMNAAVRAVTRAGIFYGCKVYACYEGYTGLVKGgDMLKeLQWQDVRGLLSIGGTIIGTARSKEFRER 290
Cdd:PRK03202 2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG-DIVK-LDLKSVSDIINRGGTILGSARFPEFKDE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 291 WGRLQACYNMVSNGIDALVVCGGDGSLTGADLFrnewpelikellgegkitkeqyeTHRNLTIVGLVGSIDNDMCGTDST 370
Cdd:PRK03202 80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAKRL-----------------------TEHGIPVIGLPGTIDNDIAGTDYT 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 371 IGAYSSLERIIELVDYIDATAASHSRAFVVEVMGRHCGWLGLMSGIATGADYIFIPERPPSetnwKDDLKKVCLRHREKG 450
Cdd:PRK03202 137 IGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFD----IEELCAKIKKGRERG 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 451 RRKTTVIVAEGAID-DQLnpitSEEVKDvlvEIGLDTRITRLGHVQRGGAPCAFDRFLATVQGVDAVRAVLESTPAIpsp 529
Cdd:PRK03202 213 KKHAIIVVAEGVMPaEEL----AKEIEE---RTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGR--- 282
|
330 340
....*....|....*....|....*.
gi 1051425808 530 VISILENKIVRQPLVESVAQTKTVSD 555
Cdd:PRK03202 283 MVGIQNNKIVHVPIEEAVENMKHPFD 308
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
210-556 |
6.40e-113 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 351.68 E-value: 6.40e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 210 KKKIAIITSGGDAPGMNAAVRAVTRAGIFYGCKVYACYEGYTGLVKGGdmLKELQWQDVRGLLSIGGTIIGTARSKEFRE 289
Cdd:COG0205 1 MKRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGD--IIDLTREDVSGILQRGGTILGSSRSKPFKT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 290 RWGRLQACYNMVSNGIDALVVCGGDGSLTGADLFRNEWPelikellgegkitkeqyethrnLTIVGLVGSIDNDMCGTDS 369
Cdd:COG0205 79 EEGREKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG----------------------IPVVGIPKTIDNDLPGTDY 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 370 TIGAYSSLERIIELVDYIDATAASHSRAFVVEVMGRHCGWLGLMSGIATGADYIFIPERPPSEtnwkDDLKKVCLRHREK 449
Cdd:COG0205 137 TIGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDL----DKLLEKLKERRKR 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 450 GRRKTTVIVAEGAIDDQLNPI---------------TSEEVKDVLVE-IGLDTRITRLGHVQRGGAPCAFDRFLATVQGV 513
Cdd:COG0205 213 GKGYSIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEErTGIETRVTVLGHLQRGGSPSAFDRVLASRLGA 292
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1051425808 514 DAVRAVLESTPAIpspVISILENKIVRQPLVESVAQTKTVSDA 556
Cdd:COG0205 293 AAVELLLEGKTGV---MVGIRRGEIVLVPLEEVANKEKPVDPD 332
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
600-886 |
1.08e-103 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 324.29 E-value: 1.08e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 600 NIAIIHVGAPTSALNPATRVATLNSLAKGHRVFAIRNGFAGLIrHGAVRELNWIDVEDWHNTGGSEIGTNRSLPS---DD 676
Cdd:pfam00365 1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLV-EGDIDELTWRDVSGILNRGGTILGTSRSKPFkteEG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 677 MGTVAYYFQQYKFDGLIIIGGFEAFTALYQLDAARaqypifNIPMCCLPATVSNNVPGTEYSLGSDTCLNTLSGYCDAVK 756
Cdd:pfam00365 80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEER------GIPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 757 QSASaSRRRTFVVEVQGGYSGYLASYAGLITGALAVYTPENPINLQTVQEDIELLTRtyeeddGKNRSgkIFIHNEKASk 836
Cdd:pfam00365 154 DTAS-SHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKELRK------GKRFS--IIVVAEGAS- 223
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1051425808 837 vyTTDLIAAIIGEagKGRFESRTAVPGHVQQGKSPSSIDRVNACRLAIKC 886
Cdd:pfam00365 224 --DGEFLAKLIEE--GTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKA 269
|
|
| PFKA_ATP |
TIGR02482 |
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ... |
212-547 |
1.01e-97 |
|
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 213713 [Multi-domain] Cd Length: 301 Bit Score: 310.05 E-value: 1.01e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 212 KIAIITSGGDAPGMNAAVRAVTRAGIFYGCKVYACYEGYTGLVKGgdMLKELQWQDVRGLLSIGGTIIGTARSKEFRERW 291
Cdd:TIGR02482 1 KIGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLING--KIEPLESKNVSGIIHRGGTILGTARCPEFKTEE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 292 GRLQACYNMVSNGIDALVVCGGDGSLTGADLFrnewpelikellgegkitkeqYETHrNLTIVGLVGSIDNDMCGTDSTI 371
Cdd:TIGR02482 79 VREKAVENLKKLGIEGLVVIGGDGSYTGAQKL---------------------YEEG-GIPVIGLPGTIDNDIPGTDYTI 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 372 GAYSSLERIIELVDYIDATAASHSRAFVVEVMGRHCGWLGLMSGIATGADYIFIPERPPSetnwKDDLKKVCLRHREKGR 451
Cdd:TIGR02482 137 GFDTALNTIIDAVDKIRDTATSHERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYD----IDELIQRLKEQHEAGK 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 452 RKTTVIVAEGAIDDQLNPItSEEVKDvlvEIGLDTRITRLGHVQRGGAPCAFDRFLATVQGVDAVRAVLESTPAIpspVI 531
Cdd:TIGR02482 213 KHSIIIVAEGNIVGSAKEV-AKKIEE---KTGIETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLEGKGGV---MI 285
|
330
....*....|....*.
gi 1051425808 532 SILENKIVRQPLVESV 547
Cdd:TIGR02482 286 GIQNNKIVTHPIEEAL 301
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
211-552 |
1.16e-85 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 278.14 E-value: 1.16e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 211 KKIAIITSGGDAPGMNAAVRAVTRAGIFYGCKVYACYEGYTGLVKGGdmLKELQWQDVRGLLSIGGTIIGTARSKEFRER 290
Cdd:cd00763 1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGD--IVPLDRYSVSDIINRGGTFLGSARFPEFKDE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 291 WGRLQACYNMVSNGIDALVVCGGDGSLTGAdlfrnewpeliKELLGEGkitkeqyethrnLTIVGLVGSIDNDMCGTDST 370
Cdd:cd00763 79 EGQAKAIEQLKKHGIDALVVIGGDGSYMGA-----------MRLTEHG------------FPCVGLPGTIDNDIPGTDYT 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 371 IGAYSSLERIIELVDYIDATAASHSRAFVVEVMGRHCGWLGLMSGIATGADYIFIPERPPSETNWKDDLKkvclRHREKG 450
Cdd:cd00763 136 IGFDTALNTVVEAIDRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIK----AGIERG 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 451 RRKTTVIVAEGAID-DQLnpitseeVKDVLVEIGLDTRITRLGHVQRGGAPCAFDRFLATVQGVDAVRAVLESTPAIpsp 529
Cdd:cd00763 212 KKHAIVVVAEGVYDvDEL-------AKEIEEATGFETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLAGKGGL--- 281
|
330 340
....*....|....*....|...
gi 1051425808 530 VISILENKIVRQPLVESVAQTKT 552
Cdd:cd00763 282 AVGIQNEQLVHHDIIDAIENMKP 304
|
|
| PFK_mixed |
TIGR02483 |
phosphofructokinase; Members of this family that are characterized, save one, are ... |
212-547 |
8.01e-79 |
|
phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 274155 [Multi-domain] Cd Length: 324 Bit Score: 259.93 E-value: 8.01e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 212 KIAIITSGGDAPGMNAAVRAVTRAGIF-YGCKVYACYEGYTGLVKGgDMLKELQWQDVRGLLSIGGTIIGTARSKEFR-E 289
Cdd:TIGR02483 1 RIGVLTGGGDCPGLNAVIRGVVRRAIAeYGWEVIGIRDGWRGLLEG-DTVPLLDLEDVRGILPRGGTILGSSRTNPFKyE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 290 RWGRLQACYNMVSNGIDALVVCGGDGSLTGADLFrnewpelikellgegkitkeqyeTHRNLTIVGLVGSIDNDMCGTDS 369
Cdd:TIGR02483 80 EDGDDKIVANLKELGLDALIAIGGDGTLGIARRL-----------------------ADKGLPVVGVPKTIDNDLEATDY 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 370 TIGAYSSLERIIELVDYIDATAASHSRAFVVEVMGRHCGWLGLMSGIATGADYIFIPERPPsetnwkdDLKKVCLRHRE- 448
Cdd:TIGR02483 137 TFGFDTAVEIATEALDRLHTTAESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEIPF-------DIDSVCEKVREr 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 449 --KGRRKTTVIVAEGAIDDQLNPITSEEVKDVLVEI-----------------GLDTRITRLGHVQRGGAPCAFDRFLAT 509
Cdd:TIGR02483 210 faRGKRFAIVVVAEGAKPKGGEMVVQEGVKDAFGHVrlggignwlaeeierrtGIETRATVLGHLQRGGSPSAFDRVLAT 289
|
330 340 350
....*....|....*....|....*....|....*...
gi 1051425808 510 VQGVDAVRAVLESTPAIpspVISILENKIVRQPLVESV 547
Cdd:TIGR02483 290 RFGVAAVDLVHEGQFGH---MVALRGTDIVYVPIAEAV 324
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
188-530 |
2.69e-55 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 205.65 E-value: 2.69e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 188 LHPKKEVRSQESIVEQVKSEEGKKKIAIITSGGDAPGMNAAVRAVTRAGIFYGCKVYACYEGYTGLVKGGdmLKELQWQD 267
Cdd:TIGR02478 367 LETFLFLSIPDDDKKLVPSEASRLRIAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHD--VRELTWSD 444
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 268 VRGLLSIGGTIIGTARS---KEFRERWGRLQacynmvSNGIDALVVCGGDGSLTGA---DLFRNEWPELikellgegkit 341
Cdd:TIGR02478 445 VEGWVGEGGSELGTNRSlpgDDLGTIAYYFQ------QHKIDGLIIIGGFEAFEALyqlDAAREKYPAF----------- 507
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 342 keqyethrNLTIVGLVGSIDNDMCGTDSTIGAYSSLERIIELVDYIDATA-ASHSRAFVVEVMGRHCGWLGLMSGIATGA 420
Cdd:TIGR02478 508 --------RIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSAsASKRRVFVVETMGGYSGYLATMAGLATGA 579
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 421 DYIFIPERPPSEtnwkDDLKKVCLRHREK---GRRKTTVIVAEGAIDDqlnpITSEEVKDVLVEIG---LDTRITRLGHV 494
Cdd:TIGR02478 580 DAAYIPEEGISL----KDLQEDIEHLKETfaeGRAGKLILRNEKASKV----YTTDFIARIISEEGkgrFDARTAVLGHM 651
|
330 340 350
....*....|....*....|....*....|....*.
gi 1051425808 495 QRGGAPCAFDRFLATVQGVDAVRAVLESTPAIPSPV 530
Cdd:TIGR02478 652 QQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHAD 687
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
210-516 |
1.10e-54 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 194.52 E-value: 1.10e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 210 KKKIAIITSGGDAPGMNAAVRAVT-RAGIFYGCKVYACYEGYTGLVKGGDMLKELQWQDVRGLLSIGGTIIGTA------ 282
Cdd:PRK14071 4 KKRIGILTSGGDCAGLNAVIRAVVhRARGTYGWEVIGIRDATQGLMARPPQYIELDLDQVDDLLRMGGTILGTTnkgdpf 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 283 -----------RSKEFRERWGRLqacynmvsnGIDALVVCGGDGSLTgadlfrnewpeLIKELLGEGKItkeqyethrNL 351
Cdd:PRK14071 84 afpmpdgslrdRSQEIIDGYHSL---------GLDALIGIGGDGSLA-----------ILRRLAQQGGI---------NL 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 352 tiVGLVGSIDNDMCGTDSTIGAYSSLERIIELVDYIDATAASHSRAFVVEVMGRHCGWLGLMSGIATGADYIFIPERPPS 431
Cdd:PRK14071 135 --VGIPKTIDNDVGATEVSIGFDTAVNIATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYT 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 432 etnwkddLKKVC--LRHR-EKGRRKTTVIVAEGAIDDQLNPIT-----------------SEEVKDvlvEIGLDTRITRL 491
Cdd:PRK14071 213 -------LENVCkkIRERqEEGKNFCLVVVSEAVRTEEGEQVTktqalgedryggigqylAEQIAE---RTGAETRVTVL 282
|
330 340
....*....|....*....|....*
gi 1051425808 492 GHVQRGGAPCAFDRFLATVQGVDAV 516
Cdd:PRK14071 283 GHIQRGGIPSPRDRLLASAFGVAAV 307
|
|
| Pfk_N |
pfam18468 |
Phosphofructokinase N-terminal domain yeast; This is a phosphofructokinase (Pfk) N-terminal ... |
7-112 |
6.93e-50 |
|
Phosphofructokinase N-terminal domain yeast; This is a phosphofructokinase (Pfk) N-terminal domain found in yeast ATP-dependent 6-phosphofructokinase subunit alpha. ATP-dependent 6-phosphofructokinases (Pfks, EC 2.7.1.11) catalyze the phosphorylation of fructose 6-phosphate (F-6-P) to fructose 1,6-bisphosphate, a key control step of glycolysis in most organizms. The N-terminal domain contains the active site and is related to glyoxalase I (E.C. 4.4.1.5).
Pssm-ID: 408261 Cd Length: 98 Bit Score: 171.17 E-value: 6.93e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 7 SALSFTSFVTNDDKLFEETFNFYTKLGFHATRSYVKDNRSDFELTGISTDSIKEIWLESFPLSEVveTSAGRelRKPLQE 86
Cdd:pfam18468 1 SGLSFISFVTNDPDKFEATIKFYTKLGFSATKSYSKDTNNDFELIGVSTDSIKEIWLESFPLSEV--DSHGF--RIPWQE 76
|
90 100
....*....|....*....|....*.
gi 1051425808 87 SVGYQSeallGYSPYQSDGVVIKLRL 112
Cdd:pfam18468 77 SPGYQG----DYSPKLSDGVVIKLRL 98
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
193-516 |
9.85e-49 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 186.18 E-value: 9.85e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 193 EVRSQESIVE-QVKSEEGKKKIAIITSGGDAPGMNAAVRAVTRAGIFYGCKVYACYEGYTGLVKGGdmLKELQWQDVRGL 271
Cdd:cd00764 371 NLYKLLAIELpQPLPEKTNLNIAIVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQ--IVELGWIDVGGW 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 272 LSIGGTIIGTARSKEfRERWGrlQACYNMVSNGIDALVVCGGDGSLTGadlfrnewpelIKELLgEGkitKEQYETHrNL 351
Cdd:cd00764 449 TGRGGSELGTKRTLP-KKDLE--TIAYNFQKYGIDGLIIVGGFEAYKG-----------LLQLR-EA---REQYEEF-CI 509
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 352 TIVGLVGSIDNDMCGTDSTIGAYSSLERIIELVDYIDATAAS-HSRAFVVEVMGRHCGWLGLMSGIATGADYIFIPERPP 430
Cdd:cd00764 510 PMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGtKRRVFIVETMGGYCGYLATMTGLAVGADAAYVFEEPF 589
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 431 SETNWKDDLKKVC--LRHREK-GRRKTTVIVAEGAIDDQLNPITSEEVKDVlveigLDTRITRLGHVQRGGAPCAFDRFL 507
Cdd:cd00764 590 NIRDLQENVEHLTekMKTTIGrGLVLRNEKCNENYTTVFTYELYSEEGKGV-----FDCRTNVLGHVQQGGAPSPFDRNF 664
|
....*....
gi 1051425808 508 ATVQGVDAV 516
Cdd:cd00764 665 GTKFAVKAM 673
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
600-892 |
3.67e-46 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 169.49 E-value: 3.67e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 600 NIAIIHVGAPTSALNPATRVATLNSLAKGHRVFAIRNGFAGLIrHGAVRELNWIDVEDWHNTGGSEIGTNRSLPS---DD 676
Cdd:COG0205 3 RIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLL-EGDIIDLTREDVSGILQRGGTILGSSRSKPFkteEG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 677 MGTVAYYFQQYKFDGLIIIGGFEAFTALYQLdaarAQYpiFNIPMCCLPATVSNNVPGTEYSLGSDTCLNTLSGYCDAVK 756
Cdd:COG0205 82 REKALENLKKLGIDALVVIGGDGSLDGAAKL----AEE--YGIPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 757 QSAsASRRRTFVVEVQGGYSGYLASYAGLITGALAVYTPENPINLQTVQEDIElltRTYEEddGKNRS------------ 824
Cdd:COG0205 156 DTA-ASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKLLEKLK---ERRKR--GKGYSiivvaegagded 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1051425808 825 GKIFIHNEKASKVY-----TTDLIAAIIGEagKGRFESRTAVPGHVQQGKSPSSIDRVNACRLAIKCCNFIED 892
Cdd:COG0205 230 GEAVLEADTDAFGHvrlggIGEYLAKEIEE--RTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLE 300
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
613-897 |
2.14e-38 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 145.99 E-value: 2.14e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 613 LNPATRVATLNSLAKGHRVFAIRNGFAGLIrHGAVRELNWIDVEDWHNTGGSEIGTNRSLPSDDMGTVAYYFQQYK---F 689
Cdd:PRK03202 16 MNAAIRAVVRTAISEGLEVYGIYDGYAGLL-EGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEEGRAKAIENLKklgI 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 690 DGLIIIGGFEAFTALYQLDAaraqypiFNIPMCCLPATVSNNVPGTEYSLGSDTCLNTLSgycDAVKQ--SASASRRRTF 767
Cdd:PRK03202 95 DALVVIGGDGSYMGAKRLTE-------HGIPVIGLPGTIDNDIAGTDYTIGFDTALNTAV---EAIDRlrDTASSHERVF 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 768 VVEVQGGYSGYLASYAGLITGALAVYTPENPINLQTVQEDIELLTRTyeeddGKnRSGKIFIhnekASKVYTTDLIAAII 847
Cdd:PRK03202 165 IVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEELCAKIKKGRER-----GK-KHAIIVV----AEGVMPAEELAKEI 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1051425808 848 GEAGKgrFESRTAVPGHVQQGKSPSSIDRVNACRLAIKCCNFIEDANFQV 897
Cdd:PRK03202 235 EERTG--LETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGR 282
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
599-890 |
5.34e-38 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 145.52 E-value: 5.34e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 599 LNIAIIHVGAPTSALNPATRVATLNSLAKGHRVFAIRNGFAGLIRhGAVRELNWIDVEDWHNTGGSEIGTNRS-LPSDDM 677
Cdd:cd00363 1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVE-GDIKELDWESVSDIINRGGTIIGSARCkEFRTEE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 678 GTVAYYFQQYKF--DGLIIIGGFEAFTALYQLdAARAQYPIFNIPMCCLPATVSNNVPGTEYSLGSDTCLNTLSGYCDAV 755
Cdd:cd00363 80 GRAKAAENLKKHgiDALVVIGGDGSYTGADLL-TEEWPSKYQGFNVIGLPGTIDNDIKGTDYTIGFDTALKTIVEAIDRI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 756 KQSASaSRRRTFVVEVQGGYSGYLASYAGLITGALAVYTPENPINLQTVQEDIELLTRTYEEddGKnRSGKIFIHN---E 832
Cdd:cd00363 159 RDTAS-SHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEWEEEMVDVIKKRRER--GK-RHGIVIVAEgaiD 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1051425808 833 KASKVYTTDLIAAIIGEAGKgrFESRTAVPGHVQQGKSPSSIDRVNACRLAIKCCNFI 890
Cdd:cd00363 235 FIPKPITEKLLAKLVEERLG--FDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELL 290
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
601-883 |
3.25e-36 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 139.85 E-value: 3.25e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 601 IAIIHVGAPTSALNPATRVATLNSLAKGHRVFAIRNGFAGLIrHGAVRELNWIDVEDWHNTGGSEIGTNRsLP--SDDMG 678
Cdd:cd00763 3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLI-AGDIVPLDRYSVSDIINRGGTFLGSAR-FPefKDEEG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 679 TVAYYFQQYKF--DGLIIIGGFEAFTALYQLDAaraqypiFNIPMCCLPATVSNNVPGTEYSLGSDTCLNTLSGYCDAVK 756
Cdd:cd00763 81 QAKAIEQLKKHgiDALVVIGGDGSYMGAMRLTE-------HGFPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 757 QSASaSRRRTFVVEVQGGYSGYLASYAGLITGALAVYTPENPINLQTVQEDIELLTRTyeeddGKnRSGKIFIhnekASK 836
Cdd:cd00763 154 DTSS-SHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIER-----GK-KHAIVVV----AEG 222
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1051425808 837 VYTTDLIAAIIGEAGKgrFESRTAVPGHVQQGKSPSSIDRVNACRLA 883
Cdd:cd00763 223 VYDVDELAKEIEEATG--FETRATVLGHIQRGGSPTAFDRILASRMG 267
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
212-467 |
1.59e-26 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 114.37 E-value: 1.59e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 212 KIAIITSGGDAPGMNAAVRAVTRAGIF-YGCK-VYACYEGYTGLVKGGDMlkELQWQDVRGLLSIGGTIIGTARSKEFRE 289
Cdd:PTZ00286 89 KAGIVTCGGLCPGLNVVIRELVMNLINnYGVKtIYGAKYGYKGLYKEDWI--KLDPKDVKTIHRLGGTILGSSRGGFDPK 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 290 RWGRlqacyNMVSNGIDALVVCGGDGSLTGADlfrnewpelikellgegKITKEQYETHRNLTIVGLVGSIDNDMCGTDS 369
Cdd:PTZ00286 167 VMVD-----TLIRHGINILFTLGGDGTHRGAL-----------------AIYKELRRRKLNISVVGIPKTIDNDIPIIDE 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 370 TIGAYSSLERIIELVD--YIDATAASHSRAfVVEVMGRHCGWLGLMSGIATG-ADYIFIPERPPsetnwkdDLKKVC--L 444
Cdd:PTZ00286 225 SFGFQTAVEEAQNAIRaaYVEAKSAKNGVG-IVKLMGRDSGFIALHASVASAdVNVCLIPEFDI-------PLEGVLeyI 296
|
250 260
....*....|....*....|...
gi 1051425808 445 RHREKGRRKTTVIVAEGAIDDQL 467
Cdd:PTZ00286 297 EQRLQKKGHCVIVVAEGAGQSLK 319
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
601-895 |
1.55e-22 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 100.53 E-value: 1.55e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 601 IAIIHVGAPTSALNPATRVATLNSLAK-GHRVFAIRNGFAGLI-RHGAVRELNWIDVEDWHNTGGSEIGT-NRSLP---- 673
Cdd:PRK14071 7 IGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMaRPPQYIELDLDQVDDLLRMGGTILGTtNKGDPfafp 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 674 ---------SDDMGTVayyFQQYKFDGLIIIGGFEAFTALYQLdaarAQypIFNIPMCCLPATVSNNVPGTEYSLGSDTC 744
Cdd:PRK14071 87 mpdgslrdrSQEIIDG---YHSLGLDALIGIGGDGSLAILRRL----AQ--QGGINLVGIPKTIDNDVGATEVSIGFDTA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 745 LNTLSGYCDAVKQSAsASRRRTFVVEVQGGYSGYLASYAGLITGALAVYTPENPINLQTVQEDIELLTR----------- 813
Cdd:PRK14071 158 VNIATEALDRLHFTA-ASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYTLENVCKKIRERQEegknfclvvvs 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 814 -----------TYEEDDGKNRSGKIfihnekasKVYTTDLIAAIIGEagkgrfESRTAVPGHVQQGKSPSSIDRVNACRL 882
Cdd:PRK14071 237 eavrteegeqvTKTQALGEDRYGGI--------GQYLAEQIAERTGA------ETRVTVLGHIQRGGIPSPRDRLLASAF 302
|
330
....*....|...
gi 1051425808 883 AIKCCNFIEDANF 895
Cdd:PRK14071 303 GVAAVDLIAQGKF 315
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
202-553 |
7.43e-18 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 87.17 E-value: 7.43e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 202 EQVKSEEGKKKIAIITSGGDAPGMNAAVRAVTRAGIFYGCK-VYACYEGYTGLVKGGDMLKELQWQDVRGLLSIGGTIIG 280
Cdd:PLN02884 45 KKIYFEPEEVKAAIVTCGGLCPGLNDVIRQIVFTLEIYGVKnIVGIPFGYRGFFEKGLSEMPLSRKVVQNIHLSGGSLLG 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 281 TAR-SKEFRERWGRLQAcynmvsNGIDALVVCGGDGSLTGADLFRNE-WPELIKellgegkitkeqyethrnLTIVGLVG 358
Cdd:PLN02884 125 VSRgGAKTSDIVDSIEA------RGINMLFVLGGNGTHAGANAIHNEcRKRKMK------------------VSVVGVPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 359 SIDNDMCGTDSTIGAYSSLERIIELVD--YIDATAASHSRAfVVEVMGRHCGWLGLMSGIATG-ADYIFIPERPpsetnW 435
Cdd:PLN02884 181 TIDNDILLMDKTFGFDTAVEEAQRAINsaYIEAHSAYHGIG-LVKLMGRSSGFIAMHASLASGqVDICLIPEVP-----F 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 436 KDDLKKVCLRHRE-----KGRrkTTVIVAEGAIDDQL----------NPITS-------EEVKDVLVEIGL--DTRITRL 491
Cdd:PLN02884 255 TLDGPNGVLRHLEhlietKGS--AVVCVAEGAGQDLLqktnatdasgNPVLGdigvhlqQEIKKHFKDIGVpaDVKYIDP 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1051425808 492 GHVQRGGAPCAFDRFLATVQGVDAVRAVLESTPAIpspVISILENKIVRQPLVESVAQTKTV 553
Cdd:PLN02884 333 TYMIRACRANASDAILCTVLGQNAVHGAFAGFSGI---TVGICNTHYVYLPIPEVIAYPRRV 391
|
|
| PRK14072 |
PRK14072 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; |
210-499 |
1.29e-16 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase;
Pssm-ID: 237600 [Multi-domain] Cd Length: 416 Bit Score: 83.37 E-value: 1.29e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 210 KKKIAIITSGGDAPGMNAAVRAVTRAGIFYGC--KVYACYEGYTGLVKGG--DMLKELQwQDVRGLLSIGGTIIGTARSK 285
Cdd:PRK14072 3 KGNALYAQSGGPTAVINASAAGVIEEARKHKKigKVYGARNGIIGILDEDliDLSKESD-EALAALAHTPSGALGSCRYK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 286 -----EFRERWGRLqaCYNMVSNGIDALVVCGGDGSLTGADlfrnewpelikellgegKITKEQYETHRNLTIVGLVGSI 360
Cdd:PRK14072 82 lksleEDRAEYERL--LEVFKAHDIGYFFYNGGNDSMDTAL-----------------KVSQLAKKMGYPIRCIGIPKTI 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 361 DNDMCGTDSTIGaYSSLERIIE---LVDYIDATA-ASHSRAFVVEVMGRHCGWLGLMSGIAT-----GADYIFIPERPPS 431
Cdd:PRK14072 143 DNDLPGTDHCPG-FGSAAKYIAtsvLEAALDVAAmANTSKVFILEVMGRHAGWLAAAAALAKqnpddAPHLIYLPERPFD 221
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1051425808 432 ETNWKDDLKKVclrHREKGRrkTTVIVAEGAIDDQLNPIT-SEEVKDVlveigldtritrLGHVQRGGA 499
Cdd:PRK14072 222 EEKFLADVRAI---VKRYGY--CVVVVSEGIRDADGKFIAeAGLAEDA------------FGHAQLGGV 273
|
|
| PRK06830 |
PRK06830 |
ATP-dependent 6-phosphofructokinase; |
210-489 |
1.76e-14 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235869 Cd Length: 443 Bit Score: 76.83 E-value: 1.76e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 210 KKKIAIITSGGDAPGMNAAVRAVTR-AGIFYGCK-VYACYEGYTGLVK--GGDMLkELQWQDVRGLLSIGGTIIGTARSK 285
Cdd:PRK06830 80 KVKAAIVTCGGLCPGLNDVIRAIVLeLHHHYGVRrILGIRYGYQGLIPryGHDPV-ELTPEVVADIHEFGGTILGSSRGP 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 286 efrerwgrlQACYNMVS----NGIDALVVCGGDGSLTGAdlfrnewpelikellgeGKITKEQyeTHRNLTI--VGLVGS 359
Cdd:PRK06830 159 ---------QDPEEIVDtlerMNINILFVIGGDGTLRGA-----------------SAIAEEI--ERRGLKIsvIGIPKT 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 360 IDNDMCGTDSTIGAYSSLERIIElvdyidATAASHSRAF-------VVEVMGRHCGWLGLMSGIATG-ADYIFIPERP-- 429
Cdd:PRK06830 211 IDNDINFIQKSFGFETAVEKATE------AIRCAHVEANgapngigLVKLMGRHSGFIAAYAALASKdVNFVLIPEVPfd 284
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1051425808 430 -PSETNWKDDLKKvclrhREKGRRKTTVIVAEGAIDDQLNpitSEEVKD-----VLVEIG--LDTRIT 489
Cdd:PRK06830 285 lEGPNGLLAALEK-----RLAERGHAVIVVAEGAGQELFD---DTGETDasgnpKLGDIGlfLKDRIK 344
|
|
| PRK06555 |
PRK06555 |
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated |
210-410 |
6.08e-14 |
|
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
Pssm-ID: 180620 [Multi-domain] Cd Length: 403 Bit Score: 75.04 E-value: 6.08e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 210 KKKIAIITSGGDAPGMNAAVRAVTRAgifygckvYA---------CYE-GYTGLVKGgDMLKELQwqDVRG----LLSIG 275
Cdd:PRK06555 3 VKKVALLTAGGLAPCLSSAVGGLIER--------YTeiapeveiiAYRsGYQGLLLG-DSIEITP--AVRAnaglLHRYG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 276 GTIIGTARSKE-----------FRERWGRLQ-ACYNMVSNGIDALVVCGGDGS-LTGADLFRnewpelikeLLGEgkitk 342
Cdd:PRK06555 72 GSPIGNSRVKLtnvadcvkrglVKEGENPLKvAAERLAADGVDILHTIGGDDTnTTAADLAA---------YLAE----- 137
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1051425808 343 EQYEthrnLTIVGLVGSIDNDMCGTDSTIGAYSSLERIIELVDYIDATAASHSRAFVV-EVMGRHCGWL 410
Cdd:PRK06555 138 NGYD----LTVVGLPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVINEHSANPRMLIIhEVMGRNCGWL 202
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
601-809 |
6.21e-13 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 72.00 E-value: 6.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 601 IAIIHVGAPTSALNPATR--VATLNSLAKGHRVFAIRNGFAGLIRHGAVrELNWIDVEDWHNTGGSEIGTNRSlpSDDMG 678
Cdd:PTZ00286 90 AGIVTCGGLCPGLNVVIRelVMNLINNYGVKTIYGAKYGYKGLYKEDWI-KLDPKDVKTIHRLGGTILGSSRG--GFDPK 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 679 TVAYYFQQYKFDGLIIIGG---FEAFTALYQlDAARAQYpifNIPMCCLPATVSNNVPGTEYSLGSDTCLNTLSGYCDAV 755
Cdd:PTZ00286 167 VMVDTLIRHGINILFTLGGdgtHRGALAIYK-ELRRRKL---NISVVGIPKTIDNDIPIIDESFGFQTAVEEAQNAIRAA 242
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1051425808 756 KQSASASRRRTFVVEVQGGYSGYLASYAGLITG-ALAVYTPENPINLQTVQEDIE 809
Cdd:PTZ00286 243 YVEAKSAKNGVGIVKLMGRDSGFIALHASVASAdVNVCLIPEFDIPLEGVLEYIE 297
|
|
| PTZ00468 |
PTZ00468 |
phosphofructokinase family protein; Provisional |
211-464 |
1.38e-06 |
|
phosphofructokinase family protein; Provisional
Pssm-ID: 185647 [Multi-domain] Cd Length: 1328 Bit Score: 52.67 E-value: 1.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 211 KKIAIITSGGDAPGMNAAVravtrAGIFYGCKVyaCYE-----GYTGLVKG--GDMLKELQWQDVRGLLSIGG-TIIGTA 282
Cdd:PTZ00468 103 RRIGVVLSGGQASGGHNVI-----AGLMSYIKL--CNQssqlfGFLGGPEGvySERYRELTEDDINGILNQGGfNIICSG 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 283 RSKEFRERWGR--LQACYNMVSNGidaLVVCGGDGSLTGADLFrnewPELIKEllgEGKitkeqyethrNLTIVGLVGSI 360
Cdd:PTZ00468 176 RHKIETEEQMRasLEICEKLKLHG---LVVIGGDDSNTNAAVL----AEYFKR---NSS----------STVVVGCPKTI 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 361 DNDM--------CGTDSTIGAYSSleriiELVDYIDATAASHSRAFVVEVMGRHCGWLGLMSGIATGADYIFIPERPPSE 432
Cdd:PTZ00468 236 DGDLknevietsFGYDTAVKTYSE-----QIGSIMDAIKTEGYGYYFVRLMGRSASHITLECGLQTRANMILIGEEIKEE 310
|
250 260 270
....*....|....*....|....*....|....*.
gi 1051425808 433 T----NWKDDLKKVCLRHREKGRRKTTVIVAEGAID 464
Cdd:PTZ00468 311 NrslmSIVDEIVEMILKRDSLGKKHGIVLLPEGLIE 346
|
|
| PTZ00287 |
PTZ00287 |
6-phosphofructokinase; Provisional |
212-464 |
1.74e-06 |
|
6-phosphofructokinase; Provisional
Pssm-ID: 240345 [Multi-domain] Cd Length: 1419 Bit Score: 52.35 E-value: 1.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 212 KIAIITSGGDAPGMNAAVravtrAGIFYGCKVYACYEGYTGLVKGGDMLKELQWQDVRGLL-----SIGG-TIIGTARSK 285
Cdd:PTZ00287 179 KIGIILSGGPAPGGHNVI-----SGIYDYAKRYNEQSQVIGFLGGIDGLYSKNYVTITDSLmnrfrNLGGfNMLWSGRGK 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 286 eFRERwGRLQACYNMVSN-GIDALVVCGGDGSLTGAdlfrnewpELIKELLGEGKITkeqyethrnLTIVGLVGSIDNDM 364
Cdd:PTZ00287 254 -VRNK-DDLIAIENIVAKlKLNGLVIIGGDGSNSNA--------ALISEYFAERQIP---------ISIIGIPKTIDGDL 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 365 --------CGTDSTIGAYSSLeriieLVDYIDATAASHSRAFVVEVMGRHCGWLGLMSGIATGADYIFIPERPPSET-NW 435
Cdd:PTZ00287 315 kseaieisFGFDTATKTYSEV-----IGNLCTDVKTGHNVYHVVRVMGRSASHVVLECALQTRPNIVLIGEEVEKENlSL 389
|
250 260 270
....*....|....*....|....*....|..
gi 1051425808 436 KDDLKKVC---LRHREKGRRKTTVIVAEGAID 464
Cdd:PTZ00287 390 KDIVSNIVntiLKRRSLNKNYGVILIPEGLIE 421
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
205-484 |
1.86e-06 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 51.67 E-value: 1.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 205 KSEEgkKKIAIITSGGDAPGMNAAVRAVTrAGIF--YGCK-VYACYEGYTGLVKGGDMlkELQWQDVRGLLSIGGTIIGT 281
Cdd:PLN02564 84 ESDE--VRACIVTCGGLCPGLNTVIREIV-CGLSymYGVTrILGIDGGYRGFYSRNTI--PLTPKVVNDIHKRGGTILGT 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 282 ARSKEFRERwgrlqACYNMVSNGIDALVVCGGDGSLTGADLfrnewpelikellgegkITKEQYETHRNLTIVGLVGSID 361
Cdd:PLN02564 159 SRGGHDTSK-----IVDSIQDRGINQVYIIGGDGTQKGASV-----------------IYEEIRRRGLKVAVAGIPKTID 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 362 NDMCGTDSTIGAYSSLE---RIIELVdYIDATAAsHSRAFVVEVMGRHCGWLGLMSGIAT-GADYIFIPErPPSETNWKD 437
Cdd:PLN02564 217 NDIPVIDKSFGFDTAVEeaqRAINAA-HVEAESV-ENGIGLVKLMGRYSGFIAMYATLASrDVDCCLIPE-SPFYLEGKG 293
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1051425808 438 DLKKVcLRHREKGRRKTTVIVAEGAIDDQL-NPITSEEVKD-----VLVEIGL 484
Cdd:PLN02564 294 GLFEF-IEKRLKENGHMVIVVAEGAGQDLIaESMESSDLQDasgnkLLLDVGL 345
|
|
| Pyrophosphate_PFK |
cd00765 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
202-487 |
2.26e-06 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include pyrophosphate-dependent phosphofructokinases. These are found in bacteria as well as plants. These may be dimeric nonallosteric enzymes as in bacteria or allosteric heterotetramers as in plants.
Pssm-ID: 238390 Cd Length: 550 Bit Score: 51.41 E-value: 2.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 202 EQVKSEEGKKKIAIITSGGDAPGMNAAVravtrAGIFYGCK-------VYACYEGYTGLVKGGDMlkELQWQDVRGLLSI 274
Cdd:cd00765 64 QDAPSSAPKLKIGIVLSGGQAPGGHNVI-----SGLFDYLKerakgstLYGFKGGPAGILKCDYI--ELNAEYIQPYRNT 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 275 GG-TIIGTARSK-EFRERWGrlQACYNMVSNGIDALVVCGGDGSLTGADLfrnewpeLIKELLGEGKITKeqyethrnlt 352
Cdd:cd00765 137 GGfDMICSGRTKiETEDQFK--QAEETAKKLDLDALVVIGGDDSNTNAAL-------LAENFRSKGLKTR---------- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 353 IVGLVGSIDNDM--------CGTDSTIGAYSslERIIELVdyIDATAASHSRAFvVEVMGRHCGWLGLMSGIATGADYIF 424
Cdd:cd00765 198 VIGVPKTIDGDLknkeietsFGFDTATKIYS--ELIGNVM--RDARSTGKYWHF-VKLMGRSASHIALECALKTHPNICI 272
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1051425808 425 IPERPPSE----TNWKDDLKKVCLRHREKGRRKTTVIVAEGAID---------DQLNPITSEEVKDvlvEIGLDTR 487
Cdd:cd00765 273 ISEEVSAQkqtlKNITDYMVDVICKRAELGYNFGVVLVPEGLIEfipevkeliAELNEILANEVVE---FNGLWKK 345
|
|
| PRK07085 |
PRK07085 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional |
199-320 |
7.39e-04 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
Pssm-ID: 235930 Cd Length: 555 Bit Score: 43.37 E-value: 7.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1051425808 199 SIVEQVKSEEGKKKIAIITSGGDAPGMNAAVravtrAGIFYGCKV-------YACYEGYTGLVKGgdMLKELQWQDVRGL 271
Cdd:PRK07085 59 TFVKGSESSSKPLKVGVILSGGQAPGGHNVI-----AGLFDGLKKlnpdsklFGFIGGPLGLLNG--KYIEITEEVIDEY 131
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1051425808 272 LSIGG-TIIGTARSK-EFRERwgrLQACYNMV-SNGIDALVVCGGDGSLTGA 320
Cdd:PRK07085 132 RNTGGfDMIGSGRTKiETEEQ---KEACLETVkKLKLDGLVIIGGDDSNTNA 180
|
|
| |
