Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an ...
602-761
3.14e-62
Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an adhesive function. Mutations in the meprin MAM domain affect noncovalent associations within meprin oligomers. In receptor tyrosine phosphatase mu-like molecules the MAM domain is important for homophilic cell-cell interactions.
:
Pssm-ID: 214533 [Multi-domain] Cd Length: 161 Bit Score: 207.20 E-value: 3.14e-62
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
:
Pssm-ID: 238014 [Multi-domain] Cd Length: 143 Bit Score: 183.32 E-value: 8.76e-54
C-terminal domain of neuropilin glycoprotein; This domain is found in eukaryotes at the ...
805-883
6.83e-47
C-terminal domain of neuropilin glycoprotein; This domain is found in eukaryotes at the C-terminus of neuropilins. It represents the transmembrane region of these transmembrane glycoproteins, that are predominantly co-receptors for another class of proteins known as semaphorins. The domain is found associated with pfam00754, pfam00431, pfam00629.
:
Pssm-ID: 403259 Cd Length: 82 Bit Score: 161.58 E-value: 6.83e-47
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
:
Pssm-ID: 238014 [Multi-domain] Cd Length: 143 Bit Score: 127.08 E-value: 6.60e-34
Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an ...
602-761
3.14e-62
Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an adhesive function. Mutations in the meprin MAM domain affect noncovalent associations within meprin oligomers. In receptor tyrosine phosphatase mu-like molecules the MAM domain is important for homophilic cell-cell interactions.
Pssm-ID: 214533 [Multi-domain] Cd Length: 161 Bit Score: 207.20 E-value: 3.14e-62
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
Pssm-ID: 238014 [Multi-domain] Cd Length: 143 Bit Score: 183.32 E-value: 8.76e-54
MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain ...
607-767
2.15e-53
MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain along with the associated Ig domain in type IIB receptor protein tyrosine phosphatases forms a structural unit (termed MIg) with a seamless interdomain interface. It plays a major role in homodimerization of the phosphatase ectoprotein and in cell adhesion. MAM is a beta-sandwich consisting of two five-stranded antiparallel beta-sheets rotated away from each other by approx 25 degrees, and plays a similar role in meprin metalloproteinases.
Pssm-ID: 459878 [Multi-domain] Cd Length: 159 Bit Score: 182.95 E-value: 2.15e-53
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular ...
607-760
3.27e-53
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members include: type IIB receptor protein tyrosine phosphatases (such as RPTPmu), meprins (plasma membrane metalloproteases), neuropilins (receptors of secreted semaphorins), and zonadhesins (sperm-specific membrane proteins which bind to the extracellular matrix of the egg). In meprin A and neuropilin-1 and -2, MAM is involved in homo-oligomerization. In RPTPmu, it has been associated with both homophilic adhesive (trans) interactions and lateral (cis) receptor oligomerization. In a GPI-anchored protein that is expressed in cells in the embryonic chicken spinal chord, MDGA1, the MAM domain has been linked to heterophilic interactions with axon-rich region.
Pssm-ID: 99706 Cd Length: 157 Bit Score: 182.19 E-value: 3.27e-53
C-terminal domain of neuropilin glycoprotein; This domain is found in eukaryotes at the ...
805-883
6.83e-47
C-terminal domain of neuropilin glycoprotein; This domain is found in eukaryotes at the C-terminus of neuropilins. It represents the transmembrane region of these transmembrane glycoproteins, that are predominantly co-receptors for another class of proteins known as semaphorins. The domain is found associated with pfam00754, pfam00431, pfam00629.
Pssm-ID: 403259 Cd Length: 82 Bit Score: 161.58 E-value: 6.83e-47
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
Pssm-ID: 214572 Cd Length: 139 Bit Score: 134.56 E-value: 1.11e-36
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
Pssm-ID: 238014 [Multi-domain] Cd Length: 143 Bit Score: 127.08 E-value: 6.60e-34
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
Pssm-ID: 214572 Cd Length: 139 Bit Score: 93.73 E-value: 2.36e-22
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
176-218
7.89e-07
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.
Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 48.16 E-value: 7.89e-07
Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an ...
602-761
3.14e-62
Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an adhesive function. Mutations in the meprin MAM domain affect noncovalent associations within meprin oligomers. In receptor tyrosine phosphatase mu-like molecules the MAM domain is important for homophilic cell-cell interactions.
Pssm-ID: 214533 [Multi-domain] Cd Length: 161 Bit Score: 207.20 E-value: 3.14e-62
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
Pssm-ID: 238014 [Multi-domain] Cd Length: 143 Bit Score: 183.32 E-value: 8.76e-54
MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain ...
607-767
2.15e-53
MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain along with the associated Ig domain in type IIB receptor protein tyrosine phosphatases forms a structural unit (termed MIg) with a seamless interdomain interface. It plays a major role in homodimerization of the phosphatase ectoprotein and in cell adhesion. MAM is a beta-sandwich consisting of two five-stranded antiparallel beta-sheets rotated away from each other by approx 25 degrees, and plays a similar role in meprin metalloproteinases.
Pssm-ID: 459878 [Multi-domain] Cd Length: 159 Bit Score: 182.95 E-value: 2.15e-53
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular ...
607-760
3.27e-53
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members include: type IIB receptor protein tyrosine phosphatases (such as RPTPmu), meprins (plasma membrane metalloproteases), neuropilins (receptors of secreted semaphorins), and zonadhesins (sperm-specific membrane proteins which bind to the extracellular matrix of the egg). In meprin A and neuropilin-1 and -2, MAM is involved in homo-oligomerization. In RPTPmu, it has been associated with both homophilic adhesive (trans) interactions and lateral (cis) receptor oligomerization. In a GPI-anchored protein that is expressed in cells in the embryonic chicken spinal chord, MDGA1, the MAM domain has been linked to heterophilic interactions with axon-rich region.
Pssm-ID: 99706 Cd Length: 157 Bit Score: 182.19 E-value: 3.27e-53
C-terminal domain of neuropilin glycoprotein; This domain is found in eukaryotes at the ...
805-883
6.83e-47
C-terminal domain of neuropilin glycoprotein; This domain is found in eukaryotes at the C-terminus of neuropilins. It represents the transmembrane region of these transmembrane glycoproteins, that are predominantly co-receptors for another class of proteins known as semaphorins. The domain is found associated with pfam00754, pfam00431, pfam00629.
Pssm-ID: 403259 Cd Length: 82 Bit Score: 161.58 E-value: 6.83e-47
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
Pssm-ID: 214572 Cd Length: 139 Bit Score: 134.56 E-value: 1.11e-36
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
Pssm-ID: 238014 [Multi-domain] Cd Length: 143 Bit Score: 127.08 E-value: 6.60e-34
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
Pssm-ID: 214572 Cd Length: 139 Bit Score: 93.73 E-value: 2.36e-22
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
176-218
7.89e-07
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.
Pssm-ID: 214483 [Multi-domain] Cd Length: 102 Bit Score: 48.16 E-value: 7.89e-07
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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