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Conserved domains on  [gi|1046313811|gb|ANV77399|]
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type 11 methyltransferase [Acetivibrio thermocellus DSM 2360]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 11454890)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

EC:  2.1.1.-
Gene Ontology:  GO:0032259|GO:0008168|GO:1904047
PubMed:  12504684|12826405

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 32-141 1.60e-26

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


:

Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 99.32  E-value: 1.60e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  32 PGGKILDVACGSGGYSVELAKEGYLVTAVDIEEEMVEKVKKKASEngLSINAFKCDMRELEKKiGERFDTIFCIgNSLVH 111
Cdd:COG2227    24 AGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAE--LNVDFVQGDLEDLPLE-DGSFDLVICS-EVLEH 99

                          90       100       110
                  ....*....|....*....|....*....|
gi 1046313811 112 LTSLKEitdVLGQMRRLLAEGGFLVLQIVN 141
Cdd:COG2227   100 LPDPAA---LLRELARLLKPGGLLLLSTPN 126
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 32-141 1.60e-26

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 99.32  E-value: 1.60e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  32 PGGKILDVACGSGGYSVELAKEGYLVTAVDIEEEMVEKVKKKASEngLSINAFKCDMRELEKKiGERFDTIFCIgNSLVH 111
Cdd:COG2227    24 AGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAE--LNVDFVQGDLEDLPLE-DGSFDLVICS-EVLEH 99

                          90       100       110
                  ....*....|....*....|....*....|
gi 1046313811 112 LTSLKEitdVLGQMRRLLAEGGFLVLQIVN 141
Cdd:COG2227   100 LPDPAA---LLRELARLLKPGGLLLLSTPN 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 36-133 4.14e-25

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 94.94  E-value: 4.14e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  36 ILDVACGSGGYSVELAKE-GYLVTAVDIEEEMVEKVKKKASENGLSINAFKCDMRELEKKiGERFDTIFCIGnSLVHLtS 114
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRgGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLPFP-DGSFDLVVSSG-VLHHL-P 77

                          90
                  ....*....|....*....
gi 1046313811 115 LKEITDVLGQMRRLLAEGG 133
Cdd:pfam13649  78 DPDLEAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 35-140 2.42e-17

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 74.77  E-value: 2.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  35 KILDVACGSGGYSVELAK-EGYLVTAVDIEEEMVEKVKKKASENGLS-INAFKCDMRELEKKIGERFDTIFCIGnslVHL 112
Cdd:cd02440     1 RVLDLGCGTGALALALASgPGARVTGVDISPVALELARKAAAALLADnVEVLKGDAEELPPEADESFDVIISDP---PLH 77

                          90       100
                  ....*....|....*....|....*...
gi 1046313811 113 TSLKEITDVLGQMRRLLAEGGFLVLQIV 140
Cdd:cd02440    78 HLVEDLARFLEEARRLLKPGGVLVLTLV 105
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 32-111 4.63e-13

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 66.40  E-value: 4.63e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  32 PGGKILDVACGSGGYSVELAKEGYLVTAVDIEEEMVEKVKKKASENGLS--INAFKCDmreLEKKIGeRFDTIFCIgNSL 109
Cdd:PRK07580   63 TGLRILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEARERAPEAGLAgnITFEVGD---LESLLG-RFDTVVCL-DVL 137


                  ..
gi 1046313811 110 VH 111
Cdd:PRK07580  138 IH 139
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 31-224 1.59e-06

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 47.64  E-value: 1.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  31 KPGGKILDVACGSGGYSVELAKEGYL---VTAVDIEEEMVEKVKKKaSENGLSINAFKCDMRELEKKIGErFDTI---FC 104
Cdd:TIGR01934  38 FKGQKVLDVACGTGDLAIELAKSAPDrgkVTGVDFSSEMLEVAKKK-SELPLNIEFIQADAEALPFEDNS-FDAVtiaFG 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811 105 IGNslvhltsLKEITDVLGQMRRLLAEGGFLVLqivnydriikynldglptitndeigLEFTRK--------YR-YKKes 175
Cdd:TIGR01934 116 LRN-------VTDIQKALREMYRVLKPGGRLVI-------------------------LEFSKPanallkkfYKfYLK-- 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1046313811 176 NIIEFNTSLKIKNGDCETEYNNSVELLPLKSgELAAALRNAGFSAFDFY 224
Cdd:TIGR01934 162 NVLPSIGGLISKNAEAYTYLPESIRAFPSQE-ELAAMLKEAGFEEVRYR 209
rADc smart00650
Ribosomal RNA adenine dimethylases;
24-78 1.64e-03

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 38.26  E-value: 1.64e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1046313811   24 FIKNCAGKPGGKILDVACGSGGYSVELAKEGYLVTAVDIEEEMVEKVKKKASENG 78
Cdd:smart00650   5 IVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKFAAAD 59
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 32-141 1.60e-26

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 99.32  E-value: 1.60e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  32 PGGKILDVACGSGGYSVELAKEGYLVTAVDIEEEMVEKVKKKASEngLSINAFKCDMRELEKKiGERFDTIFCIgNSLVH 111
Cdd:COG2227    24 AGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAE--LNVDFVQGDLEDLPLE-DGSFDLVICS-EVLEH 99

                          90       100       110
                  ....*....|....*....|....*....|
gi 1046313811 112 LTSLKEitdVLGQMRRLLAEGGFLVLQIVN 141
Cdd:COG2227   100 LPDPAA---LLRELARLLKPGGLLLLSTPN 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 36-133 4.14e-25

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 94.94  E-value: 4.14e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  36 ILDVACGSGGYSVELAKE-GYLVTAVDIEEEMVEKVKKKASENGLSINAFKCDMRELEKKiGERFDTIFCIGnSLVHLtS 114
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRgGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLPFP-DGSFDLVVSSG-VLHHL-P 77

                          90
                  ....*....|....*....
gi 1046313811 115 LKEITDVLGQMRRLLAEGG 133
Cdd:pfam13649  78 DPDLEAALREIARVLKPGG 96
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 4-137 2.97e-24

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 94.29  E-value: 2.97e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811   4 YREISKYYDYIFpvgenqlNFIKNCAGKPGGKILDVACGSGGYSVELAKEGYLVTAVDIEEEMVEKVKKKASENGLSINA 83
Cdd:COG2226     1 FDRVAARYDGRE-------ALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGLNVEF 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1046313811  84 FKCDMRELEKKiGERFDTIFCIgNSLVHLTSLKEitdVLGQMRRLLAEGGFLVL 137
Cdd:COG2226    74 VVGDAEDLPFP-DGSFDLVISS-FVLHHLPDPER---ALAEIARVLKPGGRLVV 122
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 31-139 1.82e-23

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 92.69  E-value: 1.82e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  31 KPGGKILDVACGSGGYSVELAKE-GYLVTAVDIEEEMVEKVKKKASENGLS--INAFKCDMRELEKkiGERFDTIFCIGn 107
Cdd:COG2230    50 KPGMRVLDIGCGWGGLALYLARRyGVRVTGVTLSPEQLEYARERAAEAGLAdrVEVRLADYRDLPA--DGQFDAIVSIG- 126

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1046313811 108 SLVHLtSLKEITDVLGQMRRLLAEGGFLVLQI 139
Cdd:COG2230   127 MFEHV-GPENYPAYFAKVARLLKPGGRLLLHT 157
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 8-181 1.12e-21

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 88.82  E-value: 1.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811   8 SKYYDYIfpVGENQLNFIKNCAG-KPGGKILDVACGSGGYSVELAKE-GYLVTAVDIEEEMVEKVKKKASENGLSINAFK 85
Cdd:COG0500     3 DSYYSDE--LLPGLAALLALLERlPKGGRVLDLGCGTGRNLLALAARfGGRVIGIDLSPEAIALARARAAKAGLGNVEFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  86 -CDMRELEKKIGERFDTIFCIGnsLVHLTSLKEITDVLGQMRRLLAEGGFLVLQIVNYDRIIKYNLDGLPTITNDEIGLE 164
Cdd:COG0500    81 vADLAELDPLPAESFDLVVAFG--VLHHLPPEEREALLRELARALKPGGVLLLSASDAAAALSLARLLLLATASLLELLL 158

                         170
                  ....*....|....*..
gi 1046313811 165 FTRKYRYKKESNIIEFN 181
Cdd:COG0500   159 LLRLLALELYLRALLAA 175
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
4-137 2.55e-19

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 82.35  E-value: 2.55e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811   4 YREISKYYD--------YIFPvGENQLNFIKNCAGKPGGKILDVACGSGGYSVELAKEGYLVTAVDIEEEMVEKVKKKas 75
Cdd:COG4976    11 FDQYADSYDaalvedlgYEAP-ALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREK-- 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046313811  76 enGLSINAFKCDMRELEkKIGERFDTIFCIGnSLVHLTSLKEitdVLGQMRRLLAEGGFLVL 137
Cdd:COG4976    88 --GVYDRLLVADLADLA-EPDGRFDLIVAAD-VLTYLGDLAA---VFAGVARALKPGGLFIF 142
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 35-140 2.42e-17

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 74.77  E-value: 2.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  35 KILDVACGSGGYSVELAK-EGYLVTAVDIEEEMVEKVKKKASENGLS-INAFKCDMRELEKKIGERFDTIFCIGnslVHL 112
Cdd:cd02440     1 RVLDLGCGTGALALALASgPGARVTGVDISPVALELARKAAAALLADnVEVLKGDAEELPPEADESFDVIISDP---PLH 77

                          90       100
                  ....*....|....*....|....*...
gi 1046313811 113 TSLKEITDVLGQMRRLLAEGGFLVLQIV 140
Cdd:cd02440    78 HLVEDLARFLEEARRLLKPGGVLVLTLV 105
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
32-138 1.27e-15

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 70.24  E-value: 1.27e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  32 PGGKILDVACGSGGYSVELAKE--GYLVTAVDIEEEMVEKVKKKASEnglsINAFKCDMRELEkkIGERFDTIFCiGNSL 109
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERfpGARVTGVDLSPEMLARARARLPN----VRFVVADLRDLD--PPEPFDLVVS-NAAL 73

                          90       100
                  ....*....|....*....|....*....
gi 1046313811 110 VHltsLKEITDVLGQMRRLLAEGGFLVLQ 138
Cdd:COG4106    74 HW---LPDHAALLARLAAALAPGGVLAVQ 99
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 37-137 2.90e-14

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 66.15  E-value: 2.90e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  37 LDVACGSGGYSVELAKEGYLVTAVDIEEEMVEKVKKKASENGLSInaFKCDMRELEKKiGERFDTIFCIgNSLVHltsLK 116
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLTF--VVGDAEDLPFP-DNSFDLVLSS-EVLHH---VE 73

                          90       100
                  ....*....|....*....|.
gi 1046313811 117 EITDVLGQMRRLLAEGGFLVL 137
Cdd:pfam08241  74 DPERALREIARVLKPGGILII 94
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 32-111 4.63e-13

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 66.40  E-value: 4.63e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  32 PGGKILDVACGSGGYSVELAKEGYLVTAVDIEEEMVEKVKKKASENGLS--INAFKCDmreLEKKIGeRFDTIFCIgNSL 109
Cdd:PRK07580   63 TGLRILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEARERAPEAGLAgnITFEVGD---LESLLG-RFDTVVCL-DVL 137


                  ..
gi 1046313811 110 VH 111
Cdd:PRK07580  138 IH 139
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 31-138 6.61e-13

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 64.36  E-value: 6.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  31 KPGGKILDVACGSGGYSVELAKEGYL---VTAVDIEEEMVEKVKKKASENGLS-INAFKCDMRELEKKIG-ERFDTIFCi 105
Cdd:pfam13847   2 DKGMRVLDLGCGTGHLSFELAEELGPnaeVVGIDISEEAIEKARENAQKLGFDnVEFEQGDIEELPELLEdDKFDVVIS- 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1046313811 106 gNSLVHLTSLKEitDVLGQMRRLLAEGGFLVLQ 138
Cdd:pfam13847  81 -NCVLNHIPDPD--KVLQEILRVLKPGGRLIIS 110
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 31-143 7.62e-12

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 61.68  E-value: 7.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  31 KPGGKILDVACGSGGYSVELAKEGYLVTAVDIEEEMVEKVKKKasenglsiNAFKCDMRELEKKIGERFDTIfcignSLV 110
Cdd:pfam13489  21 PSPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERALLN--------VRFDQFDEQEAAVPAGKFDVI-----VAR 87

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1046313811 111 HLT-SLKEITDVLGQMRRLLAEGGFLVLQIVNYD 143
Cdd:pfam13489  88 EVLeHVPDPPALLRQIAALLKPGGLLLLSTPLAS 121
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 37-135 1.64e-11

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 58.92  E-value: 1.64e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  37 LDVACGSGGYSVELAKE--GYLVTAVDIEEEMVEKVKKKASENGLS----INAFKCDMRELEkkiGERFDTIFCIgNSLV 110
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAlpGLEYTGLDISPAALEAARERLAALGLLnavrVELFQLDLGELD---PGSFDVVVAS-NVLH 76

                          90       100
                  ....*....|....*....|....*
gi 1046313811 111 HLtslKEITDVLGQMRRLLAEGGFL 135
Cdd:pfam08242  77 HL---ADPRAVLRNIRRLLKPGGVL 98
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 27-137 1.12e-09

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 55.73  E-value: 1.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  27 NCAG-KPGGKILDVACGSGGYSVELAKEGYLVTAVDIEEEMVEKVKKKASENGL-SINAFKCDMRELEKKiGERFDTIFC 104
Cdd:COG1041    20 NLAGaKEGDTVLDPFCGTGTILIEAGLLGRRVIGSDIDPKMVEGARENLEHYGYeDADVIRGDARDLPLA-DESVDAIVT 98

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1046313811 105 ---IGNSL-VHLTSLKEI-TDVLGQMRRLLAEGGFLVL 137
Cdd:COG1041    99 dppYGRSSkISGEELLELyEKALEEAARVLKPGGRVVI 136
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 24-137 1.25e-08

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 53.62  E-value: 1.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  24 FIKNCAGKPGGKILDVACGSGGYSVELAKEGYL---VTAVDIEEEMVEKVKKKASENGLSINafkcdmreLEKKIG---- 96
Cdd:PRK00216   43 TIKWLGVRPGDKVLDLACGTGDLAIALAKAVGKtgeVVGLDFSEGMLAVGREKLRDLGLSGN--------VEFVQGdaea 114

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1046313811  97 -----ERFD--TI-FCIGNslvhltsLKEITDVLGQMRRLLAEGG-FLVL 137
Cdd:PRK00216  115 lpfpdNSFDavTIaFGLRN-------VPDIDKALREMYRVLKPGGrLVIL 157
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 31-137 3.04e-08

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 52.84  E-value: 3.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  31 KPGGKILDVACGSGGYSVELAK--EGYLVTAVDIEEEMVEKVKKKASENGLS--INAFKCDMRELEKKIG-ERFDTIFC- 104
Cdd:COG4123    36 KKGGRVLDLGTGTGVIALMLAQrsPGARITGVEIQPEAAELARRNVALNGLEdrITVIHGDLKEFAAELPpGSFDLVVSn 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1046313811 105 -----IGNSLVHLTSLKEI---------TDVLGQMRRLLAEGGFLVL 137
Cdd:COG4123   116 ppyfkAGSGRKSPDEARAIarhedaltlEDLIRAAARLLKPGGRFAL 162
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 24-139 4.19e-08

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 51.73  E-value: 4.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  24 FIKNCAGKPGGKILDVACGSGGYSVELAKEGYL--VTAVDIEEEMVEKVKKKASENGLS-INAFKCDMRELEKkiGERFD 100
Cdd:COG2813    41 LLEHLPEPLGGRVLDLGCGYGVIGLALAKRNPEarVTLVDVNARAVELARANAAANGLEnVEVLWSDGLSGVP--DGSFD 118

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1046313811 101 TIFCigNSLVHlTSLKEITDVLGQM----RRLLAEGGFLVLQI 139
Cdd:COG2813   119 LILS--NPPFH-AGRAVDKEVAHALiadaARHLRPGGELWLVA 158
PLN02585 PLN02585
magnesium protoporphyrin IX methyltransferase
 19-117 4.28e-08

magnesium protoporphyrin IX methyltransferase


Pssm-ID: 215319 [Multi-domain]  Cd Length: 315  Bit Score: 52.94  E-value: 4.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  19 ENQLNFIKNCAGKPGGKILDVACGSGGYSVELAKEGYLVTAVDIEEEMVEKVKKKASENGLS---INAFKCDMRELEKKI 95
Cdd:PLN02585  131 EKVLLWLAEDGSLAGVTVCDAGCGTGSLAIPLALEGAIVSASDISAAMVAEAERRAKEALAAlppEVLPKFEANDLESLS 210

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1046313811  96 GeRFDTIFCI-----------GNSLVHLTSLKE 117
Cdd:PLN02585  211 G-KYDTVTCLdvlihypqdkaDGMIAHLASLAE 242
PRK12335 PRK12335
tellurite resistance protein TehB; Provisional
 34-134 5.01e-08

tellurite resistance protein TehB; Provisional


Pssm-ID: 183450 [Multi-domain]  Cd Length: 287  Bit Score: 52.25  E-value: 5.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  34 GKILDVACGSGGYSVELAKEGYLVTAVDIEEEMVEKVKKKASENGLSINAFKCDMRelEKKIGERFDTIFcignSLVHLT 113
Cdd:PRK12335  122 GKALDLGCGQGRNSLYLALLGFDVTAVDINQQSLENLQEIAEKENLNIRTGLYDIN--SASIQEEYDFIL----STVVLM 195

                          90       100
                  ....*....|....*....|...
gi 1046313811 114 SLK--EITDVLGQMRRLLAEGGF 134
Cdd:PRK12335  196 FLNreRIPAIIKNMQEHTNPGGY 218
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 33-140 8.22e-08

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 50.95  E-value: 8.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  33 GGKILDVACGSGGYSVE---LAKEGYLVTAVDIEEEMVEKVKKKASENGLSINA--FKCDMRELEKKIGERFDTIFCIGN 107
Cdd:PRK00377   41 GDMILDIGCGTGSVTVEaslLVGETGKVYAVDKDEKAINLTRRNAEKFGVLNNIvlIKGEAPEILFTINEKFDRIFIGGG 120

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1046313811 108 SLvhltslkEITDVLGQMRRLLAEGGFLVLQIV 140
Cdd:PRK00377  121 SE-------KLKEIISASWEIIKKGGRIVIDAI 146
PRK14968 PRK14968
putative methyltransferase; Provisional
 25-102 8.22e-08

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 50.67  E-value: 8.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  25 IKNCAGKPGGKILDVACGSGGYSVELAKEGYLVTAVDIEEEMVEKVKKKASENGLS---INAFKCDMreLEKKIGERFDT 101
Cdd:PRK14968   16 AENAVDKKGDRVLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRnngVEVIRSDL--FEPFRGDKFDV 93


                  .
gi 1046313811 102 I 102
Cdd:PRK14968   94 I 94
PRK08317 PRK08317
hypothetical protein; Provisional
 29-137 4.69e-07

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 49.16  E-value: 4.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  29 AGKPGGKILDVACGSGGYSVELAKE---GYLVTAVDIEEEMVEKVKKKASENGLSINAFKCDMRELEKKiGERFDTIfCI 105
Cdd:PRK08317   16 AVQPGDRVLDVGCGPGNDARELARRvgpEGRVVGIDRSEAMLALAKERAAGLGPNVEFVRGDADGLPFP-DGSFDAV-RS 93

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1046313811 106 GNSLVHltsLKEITDVLGQMRRLLAEGGFLVL 137
Cdd:PRK08317   94 DRVLQH---LEDPARALAEIARVLRPGGRVVV 122
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
24-136 4.77e-07

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 48.97  E-value: 4.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  24 FIKNC-AGKPGGKILDVACGSGGYSVELAK---EGYLVTAVDIEEEMVEKVKKKASENGLSINAFKCDMRELEKKIGERF 99
Cdd:pfam01209  33 FTMKCmGVKRGNKFLDVAGGTGDWTFGLSDsagSSGKVVGLDINENMLKEGEKKAKEEGKYNIEFLQGNAEELPFEDDSF 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1046313811 100 DTI---FCIGNSLVHLTSLKEitdvlgqMRRLLAEGGFLV 136
Cdd:pfam01209 113 DIVtisFGLRNFPDYLKVLKE-------AFRVLKPGGRVV 145
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
29-151 6.75e-07

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 48.88  E-value: 6.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  29 AGKPGGKILDVACGSGGYSVELAKEGYL-VTAVDIEEEMVEKVKKKASENGLS--INAFKCDMRELEkkIGERFDTIFC- 104
Cdd:COG4076    32 VVKPGDVVLDIGTGSGLLSMLAARAGAKkVYAVEVNPDIAAVARRIIAANGLSdrITVINADATDLD--LPEKADVIISe 109

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1046313811 105 -IGNSLvhltsLKE--ITDVLGQMRRLLAEGG-FLVLQIVNYDRIIKYNLD 151
Cdd:COG4076   110 mLDTAL-----LDEgqVPILNHARKRLLKPGGrIIPERITNAAQPVESPVD 155
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 31-224 1.59e-06

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 47.64  E-value: 1.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  31 KPGGKILDVACGSGGYSVELAKEGYL---VTAVDIEEEMVEKVKKKaSENGLSINAFKCDMRELEKKIGErFDTI---FC 104
Cdd:TIGR01934  38 FKGQKVLDVACGTGDLAIELAKSAPDrgkVTGVDFSSEMLEVAKKK-SELPLNIEFIQADAEALPFEDNS-FDAVtiaFG 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811 105 IGNslvhltsLKEITDVLGQMRRLLAEGGFLVLqivnydriikynldglptitndeigLEFTRK--------YR-YKKes 175
Cdd:TIGR01934 116 LRN-------VTDIQKALREMYRVLKPGGRLVI-------------------------LEFSKPanallkkfYKfYLK-- 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1046313811 176 NIIEFNTSLKIKNGDCETEYNNSVELLPLKSgELAAALRNAGFSAFDFY 224
Cdd:TIGR01934 162 NVLPSIGGLISKNAEAYTYLPESIRAFPSQE-ELAAMLKEAGFEEVRYR 209
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 17-137 6.09e-06

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 46.13  E-value: 6.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  17 VGENQLNFIKNCAGKPGGKILDVACGSGGYSVELAKEGYLV--TAVDIEEEMVEKVKKKASENglsiNAFKC-DMRELeK 93
Cdd:TIGR02072  19 MAKRLLALLKEKGIFIPASVLDIGCGTGYLTRALLKRFPQAefIALDISAGMLAQAKTKLSEN----VQFICgDAEKL-P 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1046313811  94 KIGERFDTIFCigNSLVH-LTSLKEitdVLGQMRRLLAEGGFLVL 137
Cdd:TIGR02072  94 LEDSSFDLIVS--NLALQwCDDLSQ---ALSELARVLKPGGLLAF 133
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
31-137 6.29e-06

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 46.32  E-value: 6.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  31 KPGGKILDVACGSG---------GysvelAKEgylVTAVDIEEEMVEKVKKKASENGLSiNAFKCDMRELEKkiGERFDT 101
Cdd:COG2264   147 KPGKTVLDVGCGSGilaiaaaklG-----AKR---VLAVDIDPVAVEAARENAELNGVE-DRIEVVLGDLLE--DGPYDL 215

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1046313811 102 IFC--IGNSLVHLtslkeitdvLGQMRRLLAEGGFLVL 137
Cdd:COG2264   216 VVAniLANPLIEL---------APDLAALLKPGGYLIL 244
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 32-147 1.36e-05

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 44.12  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  32 PGGKILDVACGSGGYSVELAKEG--YLVTAVDIEEEMVEKVKKKASENGL-SINAFKCDMRE-LEKKigeRFDTIFCigN 107
Cdd:pfam05175  31 LSGKVLDLGCGAGVLGAALAKESpdAELTMVDINARALESARENLAANGLeNGEVVASDVYSgVEDG---KFDLIIS--N 105

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1046313811 108 SLVHlTSLKEITDVLGQM----RRLLAEGGflVLQIV-----NYDRIIK 147
Cdd:pfam05175 106 PPFH-AGLATTYNVAQRFiadaKRHLRPGG--ELWIVanrflGYPPLLE 151
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 35-139 1.79e-05

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 44.65  E-value: 1.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  35 KILDVACGSGGYSVELAKE--GYLVTAVDIEEEMVEKVKKKASENGLSINAFKCDMRELEKKIGERFDTIfcIGN----- 107
Cdd:TIGR00536 117 HILDLGTGSGCIALALAYEfpNAEVIAVDISPDALAVAEENAEKNQLEHRVEFIQSNLFEPLAGQKIDII--VSNppyid 194

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1046313811 108 --------------SLVHLTS----LKEITDVLGQMRRLLAEGGFLVLQI 139
Cdd:TIGR00536 195 eedladlpnvvrfePLLALVGgddgLNILRQIIELAPDYLKPNGFLVCEI 244
PRK11705 PRK11705
cyclopropane fatty acyl phospholipid synthase;
31-106 2.30e-05

cyclopropane fatty acyl phospholipid synthase;


Pssm-ID: 183282  Cd Length: 383  Bit Score: 44.84  E-value: 2.30e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1046313811  31 KPGGKILDVACGSGGYSVELAKE-GYLVTAVDIEEEMVEKVKKKAseNGLSINAFKCDMRELEkkigERFDTIFCIG 106
Cdd:PRK11705  166 KPGMRVLDIGCGWGGLARYAAEHyGVSVVGVTISAEQQKLAQERC--AGLPVEIRLQDYRDLN----GQFDRIVSVG 236
PRK11036 PRK11036
tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;
36-150 2.63e-05

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;


Pssm-ID: 182918  Cd Length: 255  Bit Score: 44.18  E-value: 2.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  36 ILDVACGSGGYSVELAKEGYLVTAVDIEEEMVEKVKKKASENGLSINA--FKCDMRELEKKIGERFDTIfcignsLVH-- 111
Cdd:PRK11036   48 VLDAGGGEGQTAIKLAELGHQVILCDLSAEMIQRAKQAAEAKGVSDNMqfIHCAAQDIAQHLETPVDLI------LFHav 121

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1046313811 112 ---LTSLKEITDVLGQMrrlLAEGGFLVLQIVNYDRIIKYNL 150
Cdd:PRK11036  122 lewVADPKSVLQTLWSV---LRPGGALSLMFYNANGLLMHNM 160
adh_short pfam00106
short chain dehydrogenase; This family contains a wide variety of dehydrogenases.
 42-153 2.71e-05

short chain dehydrogenase; This family contains a wide variety of dehydrogenases.


Pssm-ID: 395056 [Multi-domain]  Cd Length: 195  Bit Score: 43.76  E-value: 2.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  42 GSGG----YSVELAKEGYLVTAVDIEEEMVEKVKKKASENGLSINAFKCDMRELE------KKIGERFDTIfcignslvh 111
Cdd:pfam00106   8 ASSGigraIAKRLAKEGAKVVLVDRSEEKLEAVAKELGALGGKALFIQGDVTDRAqvkalvEQAVERLGRL--------- 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1046313811 112 ltslkeitDVL----GQMRRllaeGGFLVLQIVNYDRIIKYNLDGL 153
Cdd:pfam00106  79 --------DILvnnaGITGL----GPFSELSDEDWERVIDVNLTGV 112
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 31-137 3.53e-05

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 43.11  E-value: 3.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  31 KPGGKILDVACGSGGYSVELAKEG-------------YLVTAVDIEEEMVEKVKKKASENGL--SINAFKCDMRELEKKI 95
Cdd:pfam01170  27 KPGDPLLDPMCGSGTILIEAALMGaniapgkfdarvrAPLYGSDIDRRMVQGARLNAENAGVgdLIEFVQADAADLPLLE 106

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1046313811  96 GErFDTIFC---IGNSLVHLTSLKEITDVLGQ-MRRLLAEGGFLVL 137
Cdd:pfam01170 107 GS-VDVIVTnppYGIRLGSKGALEALYPEFLReAKRVLRGGGWLVL 151
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 31-103 3.68e-05

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 44.01  E-value: 3.68e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046313811  31 KPGGKILDVACGSGGYSVELAKEGYLVTAVDIEEEMVEKVKKKASENGLS-INAFKCDMREL--EKKIGERFDTIF 103
Cdd:COG2265   232 TGGERVLDLYCGVGTFALPLARRAKKVIGVEIVPEAVEDARENARLNGLKnVEFVAGDLEEVlpELLWGGRPDVVV 307
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 28-137 4.96e-05

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 43.63  E-value: 4.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  28 CAGKpggKILDVACGSGGYSVELAKEG-YLVTAVDIEEEMVEKVKKKASENGLSI-------NAFKcDMRELEKKiGERF 99
Cdd:COG1092   215 AKGK---RVLNLFSYTGGFSVHAAAGGaKSVTSVDLSATALEWAKENAALNGLDDrhefvqaDAFD-WLRELARE-GERF 289

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1046313811 100 DTIFC-----IgnslvhlTSLKEITDVL-GQMR------RLLAEGGFLVL 137
Cdd:COG1092   290 DLIILdppafA-------KSKKDLFDAQrDYKDlnrlalKLLAPGGILVT 332
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 31-137 1.53e-04

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 41.87  E-value: 1.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  31 KPGGKILDVACGSGGYSVELAKEGY-LVTAVDIEEEMVEKVKKKASENGLSINAFKCDMRELEKkigERFDTIFC--IGN 107
Cdd:pfam06325 160 KPGESVLDVGCGSGILAIAALKLGAkKVVGVDIDPVAVRAAKENAELNGVEARLEVYLPGDLPK---EKADVVVAniLAD 236

                          90       100       110
                  ....*....|....*....|....*....|
gi 1046313811 108 SLVHLTSlkeitdvlgQMRRLLAEGGFLVL 137
Cdd:pfam06325 237 PLIELAP---------DIYALVKPGGYLIL 257
PRK11207 PRK11207
tellurite resistance methyltransferase TehB;
32-134 3.29e-04

tellurite resistance methyltransferase TehB;


Pssm-ID: 183040  Cd Length: 197  Bit Score: 40.49  E-value: 3.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  32 PGGKILDVACGSGGYSVELAKEGYLVTAVDIEE---EMVEKVkkKASENGLSINAFKCDMRELekKIGERFDTIFCigNS 108
Cdd:PRK11207   30 KPGKTLDLGCGNGRNSLYLAANGFDVTAWDKNPmsiANLERI--KAAENLDNLHTAVVDLNNL--TFDGEYDFILS--TV 103

                          90       100
                  ....*....|....*....|....*.
gi 1046313811 109 LVHLTSLKEITDVLGQMRRLLAEGGF 134
Cdd:PRK11207  104 VLMFLEAKTIPGLIANMQRCTKPGGY 129
PRK06202 PRK06202
hypothetical protein; Provisional
 36-128 4.14e-04

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 40.37  E-value: 4.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  36 ILDVACGSGGYSVELA----KEGY--LVTAVDIEEEMVEKVKKKASENGLSINAFKCDmrELEKKiGERFDTIFCigNSL 109
Cdd:PRK06202   64 LLDIGCGGGDLAIDLArwarRDGLrlEVTAIDPDPRAVAFARANPRRPGVTFRQAVSD--ELVAE-GERFDVVTS--NHF 138

                          90
                  ....*....|....*....
gi 1046313811 110 VHLTSLKEITDVLGQMRRL 128
Cdd:PRK06202  139 LHHLDDAEVVRLLADSAAL 157
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
31-168 4.93e-04

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 40.14  E-value: 4.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  31 KPGGKILDVACGSG---------GysvelAKEgylVTAVDIEEEMVEKVKKKASENGLSINAFKcdmreleKKIGERFDT 101
Cdd:PRK00517  118 LPGKTVLDVGCGSGilaiaaaklG-----AKK---VLAVDIDPQAVEAARENAELNGVELNVYL-------PQGDLKADV 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811 102 IFC-IgnslvhltsLKEITDVLG-QMRRLLAEGGFLVL------QIvnyDRIIK----YNLDGLPTITNDE-IGLEFTRK 168
Cdd:PRK00517  183 IVAnI---------LANPLLELApDLARLLKPGGRLILsgileeQA---DEVLEayeeAGFTLDEVLERGEwVALVGKKK 250
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 25-139 6.57e-04

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 40.15  E-value: 6.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  25 IKNCAGKPGGKILDVACGSGGYSVELAKE--GYLVTAVDIEEEMVEkVKKK--ASENGLSINAFKCDMreLEKKIGERFD 100
Cdd:PRK09328  101 LEALLLKEPLRVLDLGTGSGAIALALAKErpDAEVTAVDISPEALA-VARRnaKHGLGARVEFLQGDW--FEPLPGGRFD 177

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1046313811 101 TIFC----IGNSLVHLTS---------------------LKEITDvlgQMRRLLAEGGFLVLQI 139
Cdd:PRK09328  178 LIVSnppyIPEADIHLLQpevrdhephlalfggedgldfYRRIIE---QAPRYLKPGGWLLLEI 238
rumA PRK13168
23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;
31-80 1.16e-03

23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;


Pssm-ID: 237291 [Multi-domain]  Cd Length: 443  Bit Score: 39.75  E-value: 1.16e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1046313811  31 KPGGKILDVACGSGGYSVELAKEGYLVTAVDIEEEMVEKVKKKASENGLS 80
Cdd:PRK13168  296 QPGDRVLDLFCGLGNFTLPLARQAAEVVGVEGVEAMVERARENARRNGLD 345
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
34-140 1.49e-03

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 39.15  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  34 GKILDVACGSGGYSVELAK--EGYLVTAVDIEEEMVEKVKKKASENGLSINAFKCDmreLEKKIGERFDTIfcIGNSLVH 111
Cdd:PRK09489  198 GKVLDVGCGAGVLSAVLARhsPKIRLTLSDVSAAALESSRATLAANGLEGEVFASN---VFSDIKGRFDMI--ISNPPFH 272

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1046313811 112 ---LTSLKEITDVLGQMRRLLAEGGflVLQIV 140
Cdd:PRK09489  273 dgiQTSLDAAQTLIRGAVRHLNSGG--ELRIV 302
TehB pfam03848
Tellurite resistance protein TehB;
34-134 1.59e-03

Tellurite resistance protein TehB;


Pssm-ID: 397776  Cd Length: 193  Bit Score: 38.29  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  34 GKILDVACGSGGYSVELAKEGYLVTAVDIEEEMVEKVKK-KASENGLSINAFKCDMRELekKIGERFDtiFCIGNSLVHL 112
Cdd:pfam03848  32 GKVLDLGCGQGRNSLYLSLLGYDVTAWDKNENSIANLQRiKEKENLDNIHTALYDINNA--TIDENYD--FILSTVVLMF 107

                          90       100
                  ....*....|....*....|..
gi 1046313811 113 TSLKEITDVLGQMRRLLAEGGF 134
Cdd:pfam03848 108 LEPERIPGIIANMQECTNPGGY 129
rADc smart00650
Ribosomal RNA adenine dimethylases;
24-78 1.64e-03

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 38.26  E-value: 1.64e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1046313811   24 FIKNCAGKPGGKILDVACGSGGYSVELAKEGYLVTAVDIEEEMVEKVKKKASENG 78
Cdd:smart00650   5 IVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKFAAAD 59
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
32-103 1.74e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 38.35  E-value: 1.74e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1046313811  32 PGGKILDVACGSG--GYSVELAkEGYLVTAVDIEEEMVEKVKKKASENGLSINAFKCDMRELEkkIGERFDTIF 103
Cdd:COG2263    45 EGKTVLDLGCGTGmlAIGAALL-GAKKVVGVDIDPEALEIARENAERLGVRVDFIRADVTRIP--LGGSVDTVV 115
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 31-136 2.05e-03

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 38.60  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046313811  31 KPGGKILDVACGSGGYSVELAK----EGYLVTaVDIEEEMVEKVKKKASENGLSINA-FKCdmRELEKKIGER-FDTIFc 104
Cdd:COG2519    90 FPGARVLEAGTGSGALTLALARavgpEGKVYS-YERREDFAEIARKNLERFGLPDNVeLKL--GDIREGIDEGdVDAVF- 165

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1046313811 105 ignslvhlTSLKEITDVLGQMRRLLAEGGFLV 136
Cdd:COG2519   166 --------LDMPDPWEALEAVAKALKPGGVLV 189
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 31-102 2.53e-03

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 38.30  E-value: 2.53e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1046313811  31 KPGGKILDVACGSGGYSVELAK-EGYLVTAVDIEEEMVEKVKKKASENGLS--INAFKCDMRELEKKIGERFDTI 102
Cdd:COG2520   179 KPGERVLDMFAGVGPFSIPIAKrSGAKVVAIDINPDAVEYLKENIRLNKVEdrVTPILGDAREVAPELEGKADRI 253
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 31-106 2.70e-03

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 38.08  E-value: 2.70e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046313811  31 KPGGKILDVACGSGGYSVELAKE-GYLVTAVDIEEEMVEKVKKKASENGL--SINAFKCDMRELEkkigERFDTIFCIG 106
Cdd:pfam02353  60 KPGMTLLDIGCGWGGLMRRAAERyDVNVVGLTLSKNQYKLARKRVAAEGLarKVEVLLQDYRDFD----EPFDRIVSVG 134
PRK14967 PRK14967
putative methyltransferase; Provisional
 32-104 3.54e-03

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 37.72  E-value: 3.54e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1046313811  32 PGGKILDVACGSGGYSVELAKEGYL-VTAVDIEEEMVEKVKKKASENGLSINAFKCDM-RELEkkiGERFDTIFC 104
Cdd:PRK14967   36 PGRRVLDLCTGSGALAVAAAAAGAGsVTAVDISRRAVRSARLNALLAGVDVDVRRGDWaRAVE---FRPFDVVVS 107
Methyltransf_15 pfam09445
RNA cap guanine-N2 methyltransferase; RNA cap guanine-N2 methyltransferases such as ...
 33-104 5.19e-03

RNA cap guanine-N2 methyltransferase; RNA cap guanine-N2 methyltransferases such as Schizosaccharomyces pombe Tgs1 and Giardia lamblia Tgs2 catalyze methylation of the exocyclic N2 amine of 7-methylguanosine.


Pssm-ID: 370496  Cd Length: 165  Bit Score: 36.54  E-value: 5.19e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1046313811  33 GGKILDVACGSGGYSVELAKEGYLVTAVDIEEEMVEKVKKKASENGLSINAF--KCDMRELEKKIGER---FDTIFC 104
Cdd:pfam09445   1 ATRILDVFCGGGGNTIQFANVFDSVISIDINLEHLACAQHNAEVYGVSDRIWliHGDWFELLAKLKFEkikYDCVFA 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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