NCBI Conserved Domain Search

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

293-548

2.23e-58

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 196.92 E-value: 2.23e-58

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 293 LFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFD----SVDYFNSVKRFDPVKKTWHQ 368
Cdd:COG3055    25 VYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAQDGKLYVFGGFTganpSSTPLNDVYVYDPATNTWTK 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 369 VAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLY-GKVYICGGFNGnecl 447
Cdd:COG3055   105 LAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPdGKILVIGGRNG---- 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 448 ftaevyNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANrlRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDD 527
Cdd:COG3055   181 ------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFS--DEVEAYDPATNTWTALGELPTPRHGHAAVLTDG 252

                         250       260
                  ....*....|....*....|....*
gi 1044873428 528 LLFVVGGFN----GFTTTFNVECYD 548
Cdd:COG3055   253 KVYVIGGETkpgvRTPLVTSAEVYD 277

BACK

smart00875

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...

141-242

1.94e-36

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

Pssm-ID: 197943 [Multi-domain] Cd Length: 101 Bit Score: 131.31 E-value: 1.94e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  141 CIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQ 220
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSS-SEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRRE 79

                           90       100
                   ....*....|....*....|..
gi 1044873428  221 HISILLPKVRLALMHAEYFMNN 242
Cdd:smart00875  80 HLPELLEHVRLPLLSPDYLLEV 101

BACK

pfam07707

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...

141-244

1.51e-35

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).

Pssm-ID: 462237 [Multi-domain] Cd Length: 103 Bit Score: 129.20 E-value: 1.51e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 141 CIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQ 220
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAK-SEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKK 79

                          90       100
                  ....*....|....*....|....
gi 1044873428 221 HISILLPKVRLALMHAEYFMNNVK 244
Cdd:pfam07707  80 HLPELLSAVRLPLLSPQYLLNLVE 103

mutarot_permut

TIGR03548

cyclically-permuted mutarotase family protein; Members of this protein family show essentially ...

379-536

1.48e-04

cyclically-permuted mutarotase family protein; Members of this protein family show essentially full-length homology, cyclically permuted, to YjhT from Escherichia coli. YjhT was shown to act as a mutarotase for sialic acid, and by this ability to be able to act as a virulence factor. Members of the YjhT family (TIGR03547) and this cyclically-permuted family have multiple repeats of the beta-propeller-forming Kelch repeat.

Pssm-ID: 274642 [Multi-domain] Cd Length: 331 Bit Score: 44.40 E-value: 1.48e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 379 VSVTVlGNFIYAMGGFDGYVRLNTAERYEPETNQWTLI----APMHEQRSDASATTLYGKVYICGG-FNGNEclfTAEVY 453
Cdd:TIGR03548  68 ASVST-PYGIYYVGGSPSSESFSDVLLLSLDDTKEALIietlPSLPVAFDNGSATYKDGKIYVGGGnANGKP---SNKFY 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 454 ----NTESNQWTVIA--PMRSRRSGIGVIAYGEhVYAVGGFDGAnrlRSAE------AYSPVANTWRTIPTMF----NPR 517
Cdd:TIGR03548 144 cldlSNDTSGWEELPefPGEARVQPVCQALHGK-LYVFGGFQLG---GDAIiytdgyAYSPKTNTWQTVADPVlsdgEPI 219

                         170       180
                  ....*....|....*....|..
gi 1044873428 518 SNFG---IEVVDDLLFVVGGFN 536
Cdd:TIGR03548 220 TLLGgnsVKLGDSLMLVIGGVN 241

Name

Accession

Description

Interval

E-value

PHA03098

kelch-like protein; Provisional

36-572

3.03e-85

kelch-like protein; Provisional

Pssm-ID: 222983 [Multi-domain] Cd Length: 534 Bit Score: 275.88 E-value: 3.03e-85

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  36 GKLCD--VVIKVNGFEFSAHKNILCSCSSYFRALFTSgwNNTEKKVyNIPgISPDMMKLIIEYAYTRTVPITPDNVEKLL 113
Cdd:PHA03098    7 QKFCDesIIIVNGGGIIKVHKIILSSSSEYFKKMFKN--NFKENEI-NLN-IDYDSFNEVIKYIYTGKINITSNNVKDIL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 114 AAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKD 193
Cdd:PHA03098   83 SIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYN-DPDFIYLSKNELIKILSDD 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 194 ELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFmnnVKMNDYVkdSEECKPVII---NALKAMYDLN 270
Cdd:PHA03098  162 KLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGI---KKLKRWK--LRIKKKKIVfnkRCIKIIYSKK 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 271 MNgpSNSDFTNPLTRPRLPYAILFAIGGWsggsptNAIEAYDARADRWVNVTceEESPRAYHGAAYLKGYVYIIGGFDSV 350
Cdd:PHA03098  237 YN--LNKILPRSSTFGSIIYIHITMSIFT------YNYITNYSPLSEINTII--DIHYVYCFGSVVLNNVIYFIGGMNKN 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 351 DYF-NSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASAT 429
Cdd:PHA03098  307 NLSvNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVV 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 430 TLYGKVYICGGFNGN-ECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGF---DGANRLRSAEAYSPVAN 505
Cdd:PHA03098  387 NVNNLIYVIGGISKNdELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIsyiDNIKVYNIVESYNPVTN 466

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1044873428 506 TWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVV 572
Cdd:PHA03098  467 KWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCKFPKVIGSLEKNIF 533

BTB_POZ_KLHL10

cd18240

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

22-141

1.50e-80

Pssm-ID: 349549 [Multi-domain] Cd Length: 120 Bit Score: 249.17 E-value: 1.50e-80

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  22 SAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRT 101
Cdd:cd18240     1 SAMACNVFNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1044873428 102 VPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNC 141
Cdd:cd18240    81 VPITAENVEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

293-548

2.23e-58

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 196.92 E-value: 2.23e-58

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 293 LFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFD----SVDYFNSVKRFDPVKKTWHQ 368
Cdd:COG3055    25 VYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAQDGKLYVFGGFTganpSSTPLNDVYVYDPATNTWTK 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 369 VAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLY-GKVYICGGFNGnecl 447
Cdd:COG3055   105 LAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPdGKILVIGGRNG---- 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 448 ftaevyNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANrlRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDD 527
Cdd:COG3055   181 ------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFS--DEVEAYDPATNTWTALGELPTPRHGHAAVLTDG 252

                         250       260
                  ....*....|....*....|....*
gi 1044873428 528 LLFVVGGFN----GFTTTFNVECYD 548
Cdd:COG3055   253 KVYVIGGETkpgvRTPLVTSAEVYD 277

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

328-574

1.33e-53

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 184.20 E-value: 1.33e-53

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 328 PRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPM-HSRRCYVSVTVLGNFIYAMGGFDGYVR----LNT 402
Cdd:COG3055    12 PRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGANPsstpLND 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 403 AERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGI-GVIAYGEH 481
Cdd:COG3055    92 VYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLaAAVLPDGK 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 482 VYAVGGFDGanrlrsaeaySPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTtfNVECYDEKTDEWYDAHDMS 561
Cdd:COG3055   172 ILVIGGRNG----------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSD--EVEAYDPATNTWTALGELP 239

                         250
                  ....*....|...
gi 1044873428 562 IYRSALSCCVVPG 574
Cdd:COG3055   240 TPRHGHAAVLTDG 252

BACK_KLHL10

cd18450

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...

136-215

2.57e-45

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.

Pssm-ID: 350525 [Multi-domain] Cd Length: 80 Bit Score: 155.08 E-value: 2.57e-45

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 136 LCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDP 215
Cdd:cd18450     1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKDSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHDP 80

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

365-581

6.39e-42

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 152.62 E-value: 6.39e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 365 TWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLY-GKVYICGGFNG 443
Cdd:COG3055     2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRHHAAAVAQdGKLYVFGGFTG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 444 N----ECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSN 519
Cdd:COG3055    82 AnpssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDH 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1044873428 520 F-GIEVVDDLLFVVGGFNGFTttfnvecydeKTDEWYDAHDMSIYRSALSCCVVPG-----------LANVEEY 581
Cdd:COG3055   162 LaAAVLPDGKILVIGGRNGSG----------FSNTWTTLAPLPTARAGHAAAVLGGkilvfggesgfSDEVEAY 225

BACK

smart00875

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...

141-242

1.94e-36

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

Pssm-ID: 197943 [Multi-domain] Cd Length: 101 Bit Score: 131.31 E-value: 1.94e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  141 CIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQ 220
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSS-SEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRRE 79

                           90       100
                   ....*....|....*....|..
gi 1044873428  221 HISILLPKVRLALMHAEYFMNN 242
Cdd:smart00875  80 HLPELLEHVRLPLLSPDYLLEV 101

BACK

pfam07707

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...

141-244

1.51e-35

Pssm-ID: 462237 [Multi-domain] Cd Length: 103 Bit Score: 129.20 E-value: 1.51e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 141 CIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQ 220
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAK-SEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKK 79

                          90       100
                  ....*....|....*....|....
gi 1044873428 221 HISILLPKVRLALMHAEYFMNNVK 244
Cdd:pfam07707  80 HLPELLSAVRLPLLSPQYLLNLVE 103

BTB_POZ_KLHL27_IPP

cd18256

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-143

2.61e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349565 [Multi-domain] Cd Length: 125 Bit Score: 120.97 E-value: 2.61e-32

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNV 109
Cdd:cd18256    12 NKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEVTVSNV 91

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1044873428 110 EKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIG 143
Cdd:cd18256    92 QELLVAADMLQLTEVVEICCEFLKGQLHPSNCIG 125

BTB_POZ_ZBTB_KLHL-like

cd18186

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

38-119

7.84e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349497 [Multi-domain] Cd Length: 82 Bit Score: 118.04 E-value: 7.84e-32

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  38 LCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAAD 117
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80


                  ..
gi 1044873428 118 QF 119
Cdd:cd18186    81 KL 82

BTB_POZ_KLHL12_C3IP1_DKIR

cd18242

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-141

9.22e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349551 [Multi-domain] Cd Length: 124 Bit Score: 119.47 E-value: 9.22e-32

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNV 109
Cdd:cd18242    13 NSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTETVHVTVENV 92

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1044873428 110 EKLLAAADQFNIMGIVRGCCEFLKSELCLDNC 141
Cdd:cd18242    93 QELLPAACLLQLKGVKQACCEFLESQLDPSNC 124

BTB

pfam00651

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...

29-134

1.54e-31

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

Pssm-ID: 395526 [Multi-domain] Cd Length: 107 Bit Score: 118.13 E-value: 1.54e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVpITPDN 108
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*.
gi 1044873428 109 VEKLLAAADQFNIMGIVRGCCEFLKS 134
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIK 105

BTB_POZ_KLHL7

cd18237

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

17-143

4.52e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349546 [Multi-domain] Cd Length: 126 Bit Score: 114.51 E-value: 4.52e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  17 MERKMSAMACeiFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSgwNNTEKKVYNIP--GISPDMMKLII 94
Cdd:cd18237     2 AKLLADFMGV--MNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTS--NMTESKSSEVElkDAEPDIIELLV 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1044873428  95 EYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIG 143
Cdd:cd18237    78 EFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCLG 126

BTB_POZ_KLHL19_KEAP1

cd18248

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

25-136

6.11e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349557 [Multi-domain] Cd Length: 124 Bit Score: 114.01 E-value: 6.11e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  25 ACEIFNELRLEGKLCDVVIKVNGF----EFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTR 100
Cdd:cd18248     8 AFQIMNELRLSQQLCDVTLKVKYQdpkeEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIEFAYTA 87

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1044873428 101 TVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSEL 136
Cdd:cd18248    88 SISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQL 123

BTB_POZ_KLHL8

cd18238

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-143

1.04e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349547 [Multi-domain] Cd Length: 120 Bit Score: 113.54 E-value: 1.04e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  27 EIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITP 106
Cdd:cd18238     4 KVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTLTV 83

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1044873428 107 DNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIG 143
Cdd:cd18238    84 DNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120

BACK_KLHL2_like

cd18445

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...

140-250

9.21e-29

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.

Pssm-ID: 350520 [Multi-domain] Cd Length: 114 Bit Score: 110.40 E-value: 9.21e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18445     5 NCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVK-GEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPENRK 83

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1044873428 220 QHISILLPKVRLALMHAEYFMNNVKMNDYVK 250
Cdd:cd18445    84 EHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114

BTB_POZ_KLHL26

cd18255

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-141

9.82e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349564 [Multi-domain] Cd Length: 121 Bit Score: 110.56 E-value: 9.82e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNV 109
Cdd:cd18255    10 NALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSELTLDLDCI 89

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1044873428 110 EKLLAAADQFNIMGIVRGCCEFLKSELCLDNC 141
Cdd:cd18255    90 QDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121

BTB_POZ_KLHL28_BTBD5

cd18257

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-136

1.19e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349566 [Multi-domain] Cd Length: 118 Bit Score: 110.32 E-value: 1.19e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNV 109
Cdd:cd18257    10 NLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQATV 89

                          90       100
                  ....*....|....*....|....*..
gi 1044873428 110 EKLLAAADQFNIMGIVRGCCEFLKSEL 136
Cdd:cd18257    90 ESLLPAANLLQIKLVLKECCDFLESQL 116

BTB

smart00225

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...

40-136

1.06e-27

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

Pssm-ID: 197585 [Multi-domain] Cd Length: 97 Bit Score: 107.01 E-value: 1.06e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428   40 DVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQF 119
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 1044873428  120 NIMGIVRGCCEFLKSEL 136
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

BTB_POZ_KLHL18

cd18247

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

20-134

3.37e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349556 [Multi-domain] Cd Length: 116 Bit Score: 106.21 E-value: 3.37e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  20 KMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYT 99
Cdd:cd18247     1 DLPSSGFPVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYS 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1044873428 100 RTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKS 134
Cdd:cd18247    81 GRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKE 115

BTB_POZ_KBTBD8

cd18274

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

25-144

1.98e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349583 [Multi-domain] Cd Length: 129 Bit Score: 104.68 E-value: 1.98e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  25 ACEIFNELRL---EGKLCDVVIKVN-GFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTR 100
Cdd:cd18274     6 ACSILQQLKAmydEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYTS 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1044873428 101 TVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGI 144
Cdd:cd18274    86 RVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129

BACK_KLHL12

cd18452

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...

140-264

2.84e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.

Pssm-ID: 350527 [Multi-domain] Cd Length: 136 Bit Score: 104.40 E-value: 2.84e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18452     5 NCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQ-HEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKEERE 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1044873428 220 QHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALK 264
Cdd:cd18452    84 DYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKK 128

BACK_KLHL2_Mayven

cd18512

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...

140-264

4.97e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.

Pssm-ID: 350587 [Multi-domain] Cd Length: 130 Bit Score: 103.57 E-value: 4.97e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEMVkVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18512     5 NCLGIRAFADMHACTELLNQANTYAEQHFSDVV-LSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKEVRQ 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1044873428 220 QHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALK 264
Cdd:cd18512    84 EHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMK 128

BTB_POZ_KLHL24_KRIP6

cd18253

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-141

6.18e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349562 [Multi-domain] Cd Length: 121 Bit Score: 102.61 E-value: 6.18e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  27 EIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITP 106
Cdd:cd18253     7 QVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTGKVKITT 86

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1044873428 107 DNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNC 141
Cdd:cd18253    87 ENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121

BACK_KLHL18

cd18457

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...

140-243

9.42e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.

Pssm-ID: 350532 [Multi-domain] Cd Length: 107 Bit Score: 101.62 E-value: 9.42e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEmVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18457     5 NCLGIRQFAETMMCSSLVDAANKYIQQHFIE-VSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRENRE 83

                          90       100
                  ....*....|....*....|....
gi 1044873428 220 QHISILLPKVRLALMHAEYFMNNV 243
Cdd:cd18457    84 EYLPELLSKVRLPLLRPQFLTDRV 107

BTB_POZ_KLHL2-like

cd18235

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-136

1.09e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349544 [Multi-domain] Cd Length: 121 Bit Score: 102.12 E-value: 1.09e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  13 HQPHMERkmsamACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKL 92
Cdd:cd18235     1 NPQHTQK-----AFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLL 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1044873428  93 IIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSEL 136
Cdd:cd18235    76 LIDYVYTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQL 119

BTB_POZ_KLHL21

cd18250

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-141

1.10e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349559 [Multi-domain] Cd Length: 124 Bit Score: 102.15 E-value: 1.10e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNV 109
Cdd:cd18250    13 SELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTGRVTVTQDNV 92

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1044873428 110 EKLLAAADQFNIMGIVRGCCEFLKSELCLDNC 141
Cdd:cd18250    93 EALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124

BACK_KLHL16_gigaxonin

cd18455

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...

140-232

1.27e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.

Pssm-ID: 350530 [Multi-domain] Cd Length: 97 Bit Score: 100.85 E-value: 1.27e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEmVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18455     4 NCIGIRDFAERFSCPHVHYVATEYLETHFRD-VSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEERK 82

                          90
                  ....*....|...
gi 1044873428 220 QHISILLPKVRLA 232
Cdd:cd18455    83 VHLKDLMSSCWRS 95

BACK_KLHL3

cd18513

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...

140-264

5.24e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.

Pssm-ID: 350588 [Multi-domain] Cd Length: 130 Bit Score: 100.53 E-value: 5.24e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEmVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18513     5 NCLGIRAFADVHTCTELLQQANAYAEQHFPE-VMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKEARL 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1044873428 220 QHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALK 264
Cdd:cd18513    84 EHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMK 128

BTB_POZ_KLHL40_KBTBD5

cd18340

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

36-144

3.34e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349649 [Multi-domain] Cd Length: 134 Bit Score: 98.37 E-value: 3.34e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  36 GKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAA 115
Cdd:cd18340    25 NKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFAA 104

                          90       100
                  ....*....|....*....|....*....
gi 1044873428 116 ADQFNIMGIVRGCCEFLKSELCLDNCIGI 144
Cdd:cd18340   105 ANMFQIPSIFTVCVSFLQKRLCLSNCLAI 133

BTB_POZ_KBTBD6_7

cd18273

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-146

3.82e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349582 [Multi-domain] Cd Length: 142 Bit Score: 98.36 E-value: 3.82e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  32 LRLEGKLCDVVIKVNGFE--------FSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVP 103
Cdd:cd18273    20 FYDARLLTDVTIEVNGPGsgpgsgrlFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSESMALIIDYCYTGRVT 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1044873428 104 ITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICK 146
Cdd:cd18273   100 LSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGILK 142

BTB_POZ_KLHL6

cd18236

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-143

4.04e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349545 [Multi-domain] Cd Length: 129 Bit Score: 98.00 E-value: 4.04e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  32 LRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEK 111
Cdd:cd18236    18 LRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVLITKQNVQR 97

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1044873428 112 LLAAADQFNIMGIVRGCCEFLKSELCLDNCIG 143
Cdd:cd18236    98 VLEAASLFQFLRMVDACASFLTEALHPENCVG 129

BACK_KLHL29_KBTBD9

cd18468

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...

140-238

6.76e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.

Pssm-ID: 350543 [Multi-domain] Cd Length: 102 Bit Score: 96.33 E-value: 6.76e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEmVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18468     4 NCLGIWALAEALQCTELHNMAKAYALQNFPD-VARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKNRK 82

                          90
                  ....*....|....*....
gi 1044873428 220 QHISILLPKVRLALMHAEY 238
Cdd:cd18468    83 QHIAELLAVVRLPFIHPSY 101

BTB_POZ_KLHL35

cd18265

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-143

2.34e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349574 [Multi-domain] Cd Length: 128 Bit Score: 95.61 E-value: 2.34e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  27 EIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITP 106
Cdd:cd18265    12 QVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRIQE 91

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1044873428 107 DNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIG 143
Cdd:cd18265    92 DNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128

BACK_KLHL20

cd18459

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...

140-234

2.57e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.

Pssm-ID: 350534 [Multi-domain] Cd Length: 100 Bit Score: 94.42 E-value: 2.57e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEmVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18459     6 NCLGIRAFADTHACRELLRIADKFTQHNFQE-VMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNIQERR 84

                          90
                  ....*....|....*
gi 1044873428 220 QHISILLPKVRLALM 234
Cdd:cd18459    85 PHLPQVLQHVRLPLL 99

BTB_POZ_ZBTB7A

cd18326

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-132

2.88e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349635 [Multi-domain] Cd Length: 120 Bit Score: 95.00 E-value: 2.88e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDN 108
Cdd:cd18326    16 LNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALLDFAYTATLTVSTSN 95

                          90       100
                  ....*....|....*....|....
gi 1044873428 109 VEKLLAAADQFNIMGIVRGCCEFL 132
Cdd:cd18326    96 VGDILSAARLLEIPAVSHVCADLL 119

BTB_POZ_KLHL16_gigaxonin

cd18245

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-133

4.05e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349554 [Multi-domain] Cd Length: 111 Bit Score: 94.33 E-value: 4.05e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVY--NIPGISPDMMKLIIEYAYTRTVPITPD 107
Cdd:cd18245     6 NSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYkiELEGISVEVMEEILDYIYTGQIKLSED 85

                          90       100
                  ....*....|....*....|....*.
gi 1044873428 108 NVEKLLAAADQFNIMGIVRGCCEFLK 133
Cdd:cd18245    86 NIQDIVQAADLLLMTDLKDLCCEFLE 111

BTB_POZ_KLHL20_KLEIP

cd18249

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-143

4.20e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349558 [Multi-domain] Cd Length: 128 Bit Score: 94.83 E-value: 4.20e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  27 EIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITP 106
Cdd:cd18249    12 EAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYTSQITVEE 91

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1044873428 107 DNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIG 143
Cdd:cd18249    92 GNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCLG 128

BTB_POZ_KLHL2_Mayven

cd18338

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

16-136

5.54e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349647 [Multi-domain] Cd Length: 121 Bit Score: 94.37 E-value: 5.54e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  16 HMERkmsamACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIE 95
Cdd:cd18338     4 HMKK-----AFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLID 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1044873428  96 YAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSEL 136
Cdd:cd18338    79 YVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQL 119

BACK_KLHL19_KEAP1

cd18458

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...

140-226

5.57e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.

Pssm-ID: 350533 [Multi-domain] Cd Length: 91 Bit Score: 93.13 E-value: 5.57e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18458     6 NCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQ-SEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDEENRR 84


                  ....*..
gi 1044873428 220 QHISILL 226
Cdd:cd18458    85 QYLEALL 91

BACK_KLHL1_like

cd18444

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...

140-241

6.04e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.

Pssm-ID: 350519 [Multi-domain] Cd Length: 106 Bit Score: 93.55 E-value: 6.04e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18444     6 NCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQ-NQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLPERK 84

                          90       100
                  ....*....|....*....|..
gi 1044873428 220 QHISILLPKVRLALMHAEYFMN 241
Cdd:cd18444    85 KHLAKLLALIRLPLLTPQFLAD 106

BTB_POZ_ZBTB7C_ZBTB36

cd18328

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-132

7.25e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349637 [Multi-domain] Cd Length: 120 Bit Score: 94.18 E-value: 7.25e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDN 108
Cdd:cd18328    16 LNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSAILEFAYTSTLTITTSN 95

                          90       100
                  ....*....|....*....|....
gi 1044873428 109 VEKLLAAADQFNIMGIVRGCCEFL 132
Cdd:cd18328    96 VKHILNAAQMLEIQCIINVCLEIM 119

BTB_POZ_ZBTB7

cd18198

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-133

8.15e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349507 [Multi-domain] Cd Length: 120 Bit Score: 93.78 E-value: 8.15e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNV 109
Cdd:cd18198    17 NEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTALLEFAYTATLTVSTANV 96

                          90       100
                  ....*....|....*....|....
gi 1044873428 110 EKLLAAADQFNIMGIVRGCCEFLK 133
Cdd:cd18198    97 GDILSAARLLEIPCVSHVCAEILD 120

BTB_POZ_KLHL40-like

cd18269

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-144

1.26e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349578 [Multi-domain] Cd Length: 133 Bit Score: 93.62 E-value: 1.26e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  31 ELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVE 110
Cdd:cd18269    20 DLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQ 99

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1044873428 111 KLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGI 144
Cdd:cd18269   100 DIFALASRFQIPSIFTVCVSYLQKRLSLSNCLAI 133

BTB_POZ_KLHL23

cd18252

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-143

1.58e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349561 [Multi-domain] Cd Length: 127 Bit Score: 93.35 E-value: 1.58e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  27 EIFNELRLEGKLCDVVIK-VNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPIT 105
Cdd:cd18252    10 DAFRTFYLDGLFTDITLQcASGQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYTSQICIT 89

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1044873428 106 PDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIG 143
Cdd:cd18252    90 ERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCLG 127

BTB_POZ_KLHL3

cd18339

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

16-136

1.88e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349648 [Multi-domain] Cd Length: 121 Bit Score: 92.86 E-value: 1.88e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  16 HMERkmsamACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIE 95
Cdd:cd18339     4 HMKK-----AFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLID 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1044873428  96 YAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSEL 136
Cdd:cd18339    79 YIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQL 119

BACK_KLHL28_BTBD5

cd18467

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...

140-234

2.67e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.

Pssm-ID: 350542 [Multi-domain] Cd Length: 99 Bit Score: 91.55 E-value: 2.67e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18467     5 NCIGISRFAETYGCHDLYLAANKYICQNFEDVCQ-TEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQERQ 83

                          90
                  ....*....|....*
gi 1044873428 220 QHISILLPKVRLALM 234
Cdd:cd18467    84 KYLAQLLHCVRLPLL 98

BTB_POZ_KLHL34

cd18264

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-142

3.82e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349573 [Multi-domain] Cd Length: 136 Bit Score: 92.55 E-value: 3.82e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDN 108
Cdd:cd18264    19 YQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLDFIYTSWLSLSLDT 98

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1044873428 109 VEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCI 142
Cdd:cd18264    99 LEDTLEAASYLQVTEAIGLCSQYLINNLAPENCC 132

BTB_POZ_KLHL9_13

cd18239

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

22-141

4.32e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349548 [Multi-domain] Cd Length: 128 Bit Score: 92.18 E-value: 4.32e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  22 SAMACEIFNELRLEGKLCDVV-IKVNGFE-FSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYT 99
Cdd:cd18239     7 SSVVLQGFDQLRGEGLLCDVTlVPGDGDEtFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNIIDFIYT 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1044873428 100 RTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNC 141
Cdd:cd18239    87 AKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128

BTB_POZ_KLHL38

cd18268

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-144

2.49e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349577 [Multi-domain] Cd Length: 129 Bit Score: 89.84 E-value: 2.49e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNV 109
Cdd:cd18268    15 NSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTGEILITRDNV 94

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1044873428 110 EKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGI 144
Cdd:cd18268    95 LPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129

BACK_KLHL38

cd18476

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...

139-235

2.65e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.

Pssm-ID: 350551 [Multi-domain] Cd Length: 99 Bit Score: 88.64 E-value: 2.65e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 139 DNCIGICKFTDYYYCPELRQKAYMFILHNFEEmVKVSAEFLELSVTELKDIIEKDELnVKQEDAVFEAILKWISHDPQNR 218
Cdd:cd18476     4 SNCLSMIRLSEILNCETLKKKAKDMALQCFPD-VAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPKAR 81

                          90
                  ....*....|....*..
gi 1044873428 219 KQHISILLPKVRLALMH 235
Cdd:cd18476    82 KGYIHDLFKKVRLQYVH 98

BACK_KBTBD3

cd18480

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

138-218

2.88e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.

Pssm-ID: 350555 [Multi-domain] Cd Length: 82 Bit Score: 88.15 E-value: 2.88e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 138 LDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQN 217
Cdd:cd18480     3 LSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQ-SQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLEA 81


                  .
gi 1044873428 218 R 218
Cdd:cd18480    82 R 82

PHA02790

Kelch-like protein; Provisional

42-554

4.46e-21

Kelch-like protein; Provisional

Pssm-ID: 165153 [Multi-domain] Cd Length: 480 Bit Score: 96.65 E-value: 4.46e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  42 VIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIpGISPDMMKL--IIEYAYTRTVPITPDNVEKLLAAADQF 119
Cdd:PHA02790   25 IIEAIGGNIIVNSTILKKLSPYFRTHLRQKYTKNKDPVTRV-CLDLDIHSLtsIVIYSYTGKVYIDSHNVVNLLRASILT 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 120 NIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVK-VSAEFLELSvteLKDIIEKDELNVK 198
Cdd:PHA02790  104 SVEFIIYTCINFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLELEDdIIDNFDYLS---MKLILESDELNVP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 199 QEDAVFEAILKWIshdpQNRKQHISILLpkvrlalmhaeYFMNNVKMNDYVKdseeckPVIINALKAMYDLnmngpsnSD 278
Cdd:PHA02790  181 DEDYVVDFVIKWY----MKRRNRLGNLL-----------LLIKNVIRSNYLS------PRGINNVKWILDC-------TK 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 279 FTNPLTRPRLPYAILFaiggwsggsptnaIEaYDARADRWVNVtceeespraYH--GAAYLKGYVYIIGGFDSVDYFNSV 356
Cdd:PHA02790  233 IFHCDKQPRKSYKYPF-------------IE-YPMNMDQIIDI---------FHmcTSTHVGEVVYLIGGWMNNEIHNNA 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 357 KRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGyvrLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVY 436
Cdd:PHA02790  290 IAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGLPN---PTSVERWFHGDAAWVNMPSLLKPRCNPAVASINNVIY 366

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 437 ICGGFNGNEClfTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGgfdganrlRSAEAYSPVANTWRTIPTMFNP 516
Cdd:PHA02790  367 VIGGHSETDT--TTEYLLPNHDQWQFGPSTYYPHYKSCALVFGRRLFLVG--------RNAEFYCESSNTWTLIDDPIYP 436

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1044873428 517 RSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEW 554
Cdd:PHA02790  437 RDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSW 474

BACK_KLHL30

cd18469

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...

140-238

4.96e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.

Pssm-ID: 350544 [Multi-domain] Cd Length: 104 Bit Score: 88.27 E-value: 4.96e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEmVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18469     7 NCLGICEFGETHGCPEVAAKAWSFLLENFEA-VSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHDPQARA 85

                          90
                  ....*....|....*....
gi 1044873428 220 QHISILLPKVRLALMHAEY 238
Cdd:cd18469    86 AHLPELLSLVHLSLLTDQY 104

BTB_POZ_NS1BP

cd18306

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

19-144

8.32e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349615 [Multi-domain] Cd Length: 124 Bit Score: 88.09 E-value: 8.32e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  19 RKMSAMACeiFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAY 98
Cdd:cd18306     1 HPESVLAK--LNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAY 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1044873428  99 TRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGI 144
Cdd:cd18306    79 TSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124

BACK_KLHL8

cd18448

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...

140-232

1.43e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.

Pssm-ID: 350523 [Multi-domain] Cd Length: 97 Bit Score: 86.59 E-value: 1.43e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSaEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18448     6 NCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECE-EFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDPQHRK 84

                          90
                  ....*....|...
gi 1044873428 220 QHISILLPKVRLA 232
Cdd:cd18448    85 RHLDDLLSQVRLP 97

BTB_POZ_KLHL1-like

cd18234

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

38-142

2.49e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349543 [Multi-domain] Cd Length: 105 Bit Score: 86.27 E-value: 2.49e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  38 LCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAAD 117
Cdd:cd18234     1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATAC 80

                          90       100
                  ....*....|....*....|....*
gi 1044873428 118 QFNIMGIVRGCCEFLKSELCLDNCI 142
Cdd:cd18234    81 LLQLSEVVEACCGFLMKQLHPSNCL 105

BACK_KLHL23

cd18462

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...

136-233

2.38e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.

Pssm-ID: 350537 [Multi-domain] Cd Length: 102 Bit Score: 83.24 E-value: 2.38e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 136 LCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDP 215
Cdd:cd18462     1 LDIDNCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQ-QEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDV 79

                          90
                  ....*....|....*...
gi 1044873428 216 QNRKQHISILLPKVRLAL 233
Cdd:cd18462    80 EKRIECAYDLLSSIKLDL 97

BTB_POZ_KLHL17_actinfilin

cd18246

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-136

2.41e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349555 [Multi-domain] Cd Length: 139 Bit Score: 84.70 E-value: 2.41e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNV 109
Cdd:cd18246    31 NRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYAYTAEIVVGEGNV 110

                          90       100
                  ....*....|....*....|....*..
gi 1044873428 110 EKLLAAADQFNIMGIVRGCCEFLKSEL 136
Cdd:cd18246   111 QTLLPAASLLQLNGVRDACCKFLLSQL 137

BTB_POZ_KLHL4

cd18336

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

35-144

8.50e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349645 [Multi-domain] Cd Length: 126 Bit Score: 82.79 E-value: 8.50e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  35 EGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLA 114
Cdd:cd18336    16 HKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYTGVLELKEDTIESLLA 95

                          90       100       110
                  ....*....|....*....|....*....|
gi 1044873428 115 AADQFNIMGIVRGCCEFLKSELCLDNCIGI 144
Cdd:cd18336    96 AACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125

BTB_POZ_KLHL31_KBTBD1

cd18260

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-142

1.42e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349569 [Multi-domain] Cd Length: 120 Bit Score: 81.78 E-value: 1.42e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  27 EIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTsgwNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITP 106
Cdd:cd18260     7 EGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILK---KDPSLQRVELNDISPLGLATVITYAYTGKLTLSL 83

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1044873428 107 DNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCI 142
Cdd:cd18260    84 YTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119

BACK_KLHL6

cd18446

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...

139-244

1.47e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.

Pssm-ID: 350521 [Multi-domain] Cd Length: 108 Bit Score: 81.36 E-value: 1.47e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 139 DNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNR 218
Cdd:cd18446     4 ENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLN-HEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKESER 82

                          90       100
                  ....*....|....*....|....*.
gi 1044873428 219 KQHISILLPKVRLALMHAEYFMNNVK 244
Cdd:cd18446    83 LPLLPRVLENVRLPLLDPWYFVETVE 108

BACK_KLHL40_KBTBD5

cd18516

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...

136-234

2.02e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.

Pssm-ID: 350591 [Multi-domain] Cd Length: 99 Bit Score: 80.57 E-value: 2.02e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 136 LCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEeMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDP 215
Cdd:cd18516     1 LCLSNCLAIFRLGLLLDCPRLAVAARDFICDRFQ-LIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQ 79

                          90
                  ....*....|....*....
gi 1044873428 216 QNRKQHISILLPKVRLALM 234
Cdd:cd18516    80 EERTKALPVLLESIRFRLM 98

BACK_KLHL4

cd18510

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...

140-234

2.94e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

Pssm-ID: 350585 [Multi-domain] Cd Length: 106 Bit Score: 80.35 E-value: 2.94e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18510     6 NCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIK-NQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDLQNRQ 84

                          90
                  ....*....|....*
gi 1044873428 220 QHISILLPKVRLALM 234
Cdd:cd18510    85 KDLGMLLSYIRLPLL 99

BTB_POZ_KLHL37_ENC1

cd18267

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-144

3.38e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349576 [Multi-domain] Cd Length: 147 Bit Score: 81.57 E-value: 3.38e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNI-PGISPDMMKLIIEYAYTRTVPITPD 107
Cdd:cd18267    31 LNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFhDSIHPEVLELLLDYAYSSRVIINEE 110

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1044873428 108 NVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGI 144
Cdd:cd18267   111 NAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147

BTB_POZ_KLHL11

cd18241

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-141

5.07e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349550 [Multi-domain] Cd Length: 135 Bit Score: 80.67 E-value: 5.07e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIKV---NGFEFSAHKNILCSCSSYFRALFTSGWNNTE------KKVYNIPGISPDMMKLIIEYAYTR 100
Cdd:cd18241    15 NEQRKQGLFCDITLAFggaGGREFRAHRSVLAAATEYFTPLLSGQFSESRsgrvemRKWSSEPGPDPDTVEAVIQYMYTG 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1044873428 101 TVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNC 141
Cdd:cd18241    95 RIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135

BACK_KLHL24

cd18463

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...

140-213

5.82e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.

Pssm-ID: 350538 [Multi-domain] Cd Length: 78 Bit Score: 78.59 E-value: 5.82e-18

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEmVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISH 213
Cdd:cd18463     6 NCLGIQKFADTHSLKQLFEKCKKFALENFVE-VSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78

BTB_POZ_KLHL29_KBTBD9

cd18258

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-143

6.42e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349567 [Multi-domain] Cd Length: 125 Bit Score: 80.02 E-value: 6.42e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALF---TSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPIT 105
Cdd:cd18258     8 LNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIkrsSRDSGGGEKLELTMSNINADVLELLLEFVYTGSLIID 87

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1044873428 106 PDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIG 143
Cdd:cd18258    88 SANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125

BTB_POZ_KBTBD2_BKLHD1

cd18270

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-142

1.02e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349579 [Multi-domain] Cd Length: 133 Bit Score: 79.66 E-value: 1.02e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  27 EIFNELRLegkLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITP 106
Cdd:cd18270    18 KFFYEQQL---LTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAIND 94

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1044873428 107 DNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCI 142
Cdd:cd18270    95 STVEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130

BACK_KEL_like

cd18508

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...

140-214

1.22e-17

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.

Pssm-ID: 350583 [Multi-domain] Cd Length: 77 Bit Score: 77.45 E-value: 1.22e-17

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHD 214
Cdd:cd18508     4 NCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQ-GEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77

BTB_POZ_ZBTB44

cd18228

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-136

1.64e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349537 [Multi-domain] Cd Length: 126 Bit Score: 79.13 E-value: 1.64e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVY------------NIPGISPdmmklIIEYA 97
Cdd:cd18228    11 NSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLVSpagkcvldlhhvTVTGFAP-----LLEYA 85

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1044873428  98 YTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSEL 136
Cdd:cd18228    86 YTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124

BACK_KLHL40_like

cd18477

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...

136-234

1.96e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.

Pssm-ID: 350552 [Multi-domain] Cd Length: 99 Bit Score: 77.96 E-value: 1.96e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 136 LCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDP 215
Cdd:cd18477     1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAK-DEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAK 79

                          90
                  ....*....|....*....
gi 1044873428 216 QNRKQHISILLPKVRLALM 234
Cdd:cd18477    80 ENRQKALPTVFESIRFRLL 98

BACK_KLHL17

cd18456

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...

140-238

2.34e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.

Pssm-ID: 350531 [Multi-domain] Cd Length: 102 Bit Score: 77.73 E-value: 2.34e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18456     5 NCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSK-TEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVDGRR 83

                          90
                  ....*....|....*....
gi 1044873428 220 QHISILLPKVRLALMHAEY 238
Cdd:cd18456    84 QHVPRLMKCVRLPLLSRDF 102

BTB_POZ_KLHL36

cd18266

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-156

2.40e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349575 [Multi-domain] Cd Length: 135 Bit Score: 78.78 E-value: 2.40e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDN 108
Cdd:cd18266    16 LNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAVIDFLYSSELPLDGGN 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1044873428 109 VEKLLAAADQFNIMGIVRGCCEFLKSELCLDNcigickftdYYYCPEL 156
Cdd:cd18266    96 IDYVLETAHLLQIWKVVDFCCEYLENEVSEEN---------YLYLQEL 134

BTB_POZ_KLHL22

cd18251

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-140

3.12e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349560 [Multi-domain] Cd Length: 125 Bit Score: 77.94 E-value: 3.12e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  32 LRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEK 111
Cdd:cd18251    17 LRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYTSELELSLDNVQE 96

                          90       100
                  ....*....|....*....|....*....
gi 1044873428 112 LLAAADQFNIMGIVRGCCEFLKSELCLDN 140
Cdd:cd18251    97 TLTAACQLQIPEVIGFCCDFLMSWVDNEN 125

BACK_KLHL7

cd18447

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...

140-233

3.33e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.

Pssm-ID: 350522 [Multi-domain] Cd Length: 98 Bit Score: 77.01 E-value: 3.33e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSaEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18447     6 NCLGISVLAECLDCPELKATADDFIHQHFTEVYKTD-EFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQ 84

                          90
                  ....*....|....
gi 1044873428 220 QHISILLPKVRLAL 233
Cdd:cd18447    85 PYMVDILAKVRFPL 98

BACK_KLHL5

cd18511

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...

140-241

4.66e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.

Pssm-ID: 350586 [Multi-domain] Cd Length: 106 Bit Score: 77.03 E-value: 4.66e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18511     6 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR-NQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDVEQRR 84

                          90       100
                  ....*....|....*....|..
gi 1044873428 220 QHISILLPKVRLALMHAEYFMN 241
Cdd:cd18511    85 KDLSKLLAYIRLPLLAPQFLAD 106

BTB_POZ_KLHL30

cd18259

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-143

4.77e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349568 [Multi-domain] Cd Length: 137 Bit Score: 77.95 E-value: 4.77e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  32 LRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEK 111
Cdd:cd18259    26 LRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYTGKLTINQGNVEA 105

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1044873428 112 LLAAADQFNIMGIVRGCCEFLKSELCLDNCIG 143
Cdd:cd18259   106 LIRTSNRLQFPTVRKVCSRYLQQQIDATNCLG 137

BACK_KLHL1

cd18509

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...

140-237

7.30e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

Pssm-ID: 350584 [Multi-domain] Cd Length: 106 Bit Score: 76.60 E-value: 7.30e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18509     6 NCLGIRAFADAQGCIELMKVAHSYTMENIMEVIR-NQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRC 84

                          90
                  ....*....|....*...
gi 1044873428 220 QHISILLPKVRLALMHAE 237
Cdd:cd18509    85 SDLSMLLAYIRLPLLPPQ 102

BTB_POZ_KLHL5

cd18337

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

16-144

2.16e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349646 [Multi-domain] Cd Length: 130 Bit Score: 75.87 E-value: 2.16e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  16 HMERKMSAMAceifNELRlEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIE 95
Cdd:cd18337     6 HAEQTFKKME----NYLR-HKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQ 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1044873428  96 YAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGI 144
Cdd:cd18337    81 YAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129

BTB_POZ_KLHL1

cd18335

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

37-144

2.98e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349644 [Multi-domain] Cd Length: 126 Bit Score: 75.47 E-value: 2.98e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  37 KLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAA 116
Cdd:cd18335    18 QLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAA 97

                          90       100
                  ....*....|....*....|....*...
gi 1044873428 117 DQFNIMGIVRGCCEFLKSELCLDNCIGI 144
Cdd:cd18335    98 CLLQLSQVVEVCCHFLMKLLHPSNCLGI 125

BTB_POZ_KLHL41_KBTBD10

cd18341

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-144

3.01e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349650 [Multi-domain] Cd Length: 133 Bit Score: 75.65 E-value: 3.01e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  31 ELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVE 110
Cdd:cd18341    20 ELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYSAEIDLNDGNVQ 99

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1044873428 111 KLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGI 144
Cdd:cd18341   100 DIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133

BTB_POZ_ARIA_plant

cd18352

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

38-140

3.04e-16

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349661 [Multi-domain] Cd Length: 116 Bit Score: 74.82 E-value: 3.04e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  38 LCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAAD 117
Cdd:cd18352    13 LSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAAD 92

                          90       100
                  ....*....|....*....|...
gi 1044873428 118 QFNIMGIVRGCCEFLKSELCLDN 140
Cdd:cd18352    93 QYLLEGLKRLCEYTIAQDLTLEN 115

BTB_POZ_ZBTB7B_ZBTB15

cd18327

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-133

3.31e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349636 [Multi-domain] Cd Length: 127 Bit Score: 75.27 E-value: 3.31e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSG-------WNNTEKKVYNIPGISPDMMKLIIEYAYTRTV 102
Cdd:cd18327    17 NEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGgggsgdlGAGGGQDVCELDFVGPEALGALLEFAYTATL 96

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1044873428 103 PITPDNVEKLLAAADQFNIMGIVRGCCEFLK 133
Cdd:cd18327    97 TISSSNMREVLRAARLLEIPCVADACADILQ 127

BTB_POZ_ZBTB17_MIZ1

cd18206

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

22-131

3.34e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349515 [Multi-domain] Cd Length: 112 Bit Score: 74.58 E-value: 3.34e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  22 SAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPdmmklIIEYAYTRT 101
Cdd:cd18206     6 SQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVDQKDVVHLDISNAAGLGQ-----VLEFMYTAK 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1044873428 102 VPITPDNVEKLLAAADQFNIMGIVRGCCEF 131
Cdd:cd18206    81 LSLSPENVDDVLAVATFLQMQDIVTACHAL 110

BACK_KLHL25_like

cd18464

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...

140-234

3.92e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.

Pssm-ID: 350539 [Multi-domain] Cd Length: 98 Bit Score: 74.07 E-value: 3.92e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18464     4 NCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRK-TEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRRH 82

                          90
                  ....*....|....*
gi 1044873428 220 QHISILLPKVRLALM 234
Cdd:cd18464    83 EVLPELLRSVRLALL 97

BACK_KLHL25_ENC2

cd18514

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...

140-234

4.16e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).

Pssm-ID: 350589 [Multi-domain] Cd Length: 99 Bit Score: 74.11 E-value: 4.16e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEeMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18514     5 NCLGMMLLSDAHQCRRLYELSWRMCLVHFE-TVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLEKRK 83

                          90
                  ....*....|....*
gi 1044873428 220 QHISILLPKVRLALM 234
Cdd:cd18514    84 DYLPELLRNVRLALL 98

BACK_KBTBD2

cd18479

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

139-231

4.43e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.

Pssm-ID: 350554 [Multi-domain] Cd Length: 96 Bit Score: 73.94 E-value: 4.43e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 139 DNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAeFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNR 218
Cdd:cd18479     4 ENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEA-FMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESR 82

                          90
                  ....*....|...
gi 1044873428 219 KQHISILLPKVRL 231
Cdd:cd18479    83 SQYLSSVLSQIRI 95

BTB_POZ_KLHL15

cd18244

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-144

8.22e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349553 [Multi-domain] Cd Length: 137 Bit Score: 74.61 E-value: 8.22e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDN 108
Cdd:cd18244    21 FRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMLT 100

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1044873428 109 VEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGI 144
Cdd:cd18244   101 VHEILQAAMYVQLTEVVKFCCSFLLAKICLDNCAEI 136

BTB_POZ_KLHL25

cd18254

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-143

8.72e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349563 [Multi-domain] Cd Length: 128 Bit Score: 74.28 E-value: 8.72e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNI-PGISPDMMKLIIEYAYTRTVPITPD 107
Cdd:cd18254    13 LNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFhDSLHPEVLELLLDFAYSSRIIINEE 92

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1044873428 108 NVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIG 143
Cdd:cd18254    93 NAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 128

BTB_POZ_calicin

cd18307

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

39-131

1.52e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349616 [Multi-domain] Cd Length: 97 Bit Score: 72.53 E-value: 1.52e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  39 CDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKV---YNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAA 115
Cdd:cd18307     2 CDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATDELsitIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLLKG 81

                          90
                  ....*....|....*.
gi 1044873428 116 ADQFNIMGIVRGCCEF 131
Cdd:cd18307    82 AKYFNIPRLKDHCVDF 97

PHA02713

hypothetical protein; Provisional

38-440

1.75e-15

hypothetical protein; Provisional

Pssm-ID: 165086 [Multi-domain] Cd Length: 557 Bit Score: 79.67 E-value: 1.75e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  38 LCDVVIKV-NGFEFSAHKNILCSCSSYFRALFTSGW--NNTEKKVyNIPGISPDMMKLIIEYAYTRTvpITPDNVEKLLA 114
Cdd:PHA02713   25 LCDVIITIgDGEEIKAHKTILAAGSKYFRTLFTTPMiiRDLVTRV-NLQMFDKDAVKNIVQYLYNRH--ISSMNVIDVLK 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 115 AADQFNIMGIVRGCCEFLKSELCLDNCIGIC-KFTDYYYCPELRQKAYMfILHNFEEMVKVSAeFLELSVTELKDIIE-K 192
Cdd:PHA02713  102 CADYLLIDDLVTDCESYIKDYTNHDTCIYMYhRLYEMSHIPIVKYIKRM-LMSNIPTLITTDA-FKKTVFEILFDIIStN 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 193 DELNVKQEDAVFEAILKWISHDPQNRKQHISIL-------LPKVRLALMHAEYFMNNV-KMNDYVKDSEECKPVIINALK 264
Cdd:PHA02713  180 DNVYLYREGYKVTILLKWLEYNYITEEQLLCILscidiqnLDKKSRLLLYSNKTINMYpSCIQFLLDNKQNRNIIPRQLC 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 265 AMYDlnmngPSNSDFTNP----LTRPRLPYAILFAIggwsggsPTNAIEaydaradrwvnvtceeesprayHGAAYLKGY 340
Cdd:PHA02713  260 LVCH-----DTKYNVCNPcilvYNINTMEYSVISTI-------PNHIIN----------------------YASAIVDNE 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 341 VYIIGGFDSVD-YFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPM 419
Cdd:PHA02713  306 IIIAGGYNFNNpSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDM 385

                         410       420
                  ....*....|....*....|.
gi 1044873428 420 HEQRSDASATTLYGKVYICGG 440
Cdd:PHA02713  386 PIALSSYGMCVLDQYIYIIGG 406

BTB_POZ_BAB-like

cd18315

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

38-123

2.07e-15

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349624 [Multi-domain] Cd Length: 85 Bit Score: 71.43 E-value: 2.07e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  38 LCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSgWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAAD 117
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKE-TPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79


                  ....*.
gi 1044873428 118 QFNIMG 123
Cdd:cd18315    80 LLQIKG 85

BACK_KLHL41_KBTBD10

cd18517

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...

136-234

2.16e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.

Pssm-ID: 350592 [Multi-domain] Cd Length: 99 Bit Score: 72.11 E-value: 2.16e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 136 LCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDP 215
Cdd:cd18517     1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISK-EEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDK 79

                          90
                  ....*....|....*....
gi 1044873428 216 QNRKQHISILLPKVRLALM 234
Cdd:cd18517    80 ENRVKSLGEIFDCIRFRLM 98

BTB2_POZ_ABTB1_BPOZ1

cd18296

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

27-137

3.21e-15

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349605 [Multi-domain] Cd Length: 121 Bit Score: 72.33 E-value: 3.21e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  27 EIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFT-----SGWNNTEKKVYNIPGISPDMMKLIIEYAYTRT 101
Cdd:cd18296     6 ELPFPPEQELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRdhfaeSEENNGSIPVVTLHDVSPEVFAIVLYYIYTDD 85

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1044873428 102 VPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELC 137
Cdd:cd18296    86 TDLPPENAYDVLYVADMYLLPGLKRLCGTVLAQSLD 121

BTB_POZ_ZBTB28_BCL6B

cd18332

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-133

3.63e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349641 [Multi-domain] Cd Length: 114 Bit Score: 71.81 E-value: 3.63e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFtSGWNNTEKKVYNIP-GISPDMMKLIIEYAYTRTVPITPDN 108
Cdd:cd18332    11 NELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIF-SGRVGEGVSVLTLPsGLEARGFQLLLDFMYTSRLPLTPRT 89

                          90       100
                  ....*....|....*....|....*
gi 1044873428 109 VEKLLAAADQFNIMGIVRGCCEFLK 133
Cdd:cd18332    90 VPAVLAAATYLQMEHVVETCRRFIQ 114

BTB2_POZ_KLHL33

cd18263

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

31-139

7.32e-15

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349572 [Multi-domain] Cd Length: 118 Bit Score: 71.00 E-value: 7.32e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  31 ELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVE 110
Cdd:cd18263     6 GLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLSWENLF 85

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1044873428 111 KLLAAADQFNIMGIVRGCCEFLKSEL----CLD 139
Cdd:cd18263    86 EATCTALQLQISGALALCLDFLQREIsparCLD 118

BTB_POZ_KLHL32

cd18261

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-136

9.23e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349570 [Multi-domain] Cd Length: 133 Bit Score: 71.15 E-value: 9.23e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDN 108
Cdd:cd18261    19 LNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFAYTGQILLEPGV 98

                          90       100
                  ....*....|....*....|....*...
gi 1044873428 109 VEKLLAAADQFNIMGIVRGCCEFLKSEL 136
Cdd:cd18261    99 IQDVLAAGSHLQLLELLSLCSHYLIQEL 126

BTB_POZ_ABTB2-like

cd18297

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

38-140

1.19e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349606 [Multi-domain] Cd Length: 117 Bit Score: 70.38 E-value: 1.19e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  38 LCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEK---LLA 114
Cdd:cd18297    12 MSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVESLDVAQDDaleLLR 91

                          90       100
                  ....*....|....*....|....*.
gi 1044873428 115 AADQFNIMGIVRGCCEFLKSELCLDN 140
Cdd:cd18297    92 AASFFQLDGLKRHCEILLSQQIDLDN 117

BACK_KBTBD8

cd18483

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

140-228

1.30e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.

Pssm-ID: 350558 [Multi-domain] Cd Length: 97 Bit Score: 69.89 E-value: 1.30e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18483     5 NSIGVFIFADHYGHQELKERSQDYIRKKFLSVTK-EQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQSKRE 83


                  ....*....
gi 1044873428 220 QHISILLPK 228
Cdd:cd18483    84 MHLPEIFAK 92

BTB_POZ_ZBTB46

cd18230

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-136

1.56e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349539 [Multi-domain] Cd Length: 125 Bit Score: 70.47 E-value: 1.56e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEK-KVYNIPGISPDMMKLIIEYAYTRTVPITPD 107
Cdd:cd18230    12 LNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQaTVTHLDIVTAQGFKAIIDFMYSAHLALTSK 91

                          90       100
                  ....*....|....*....|....*....
gi 1044873428 108 NVEKLLAAADQFNIMGIVRGCCEFLKSEL 136
Cdd:cd18230    92 NVIEVMSAASYLQMTDIVQACHNFIKAAL 120

BTB_POZ_trishanku-like

cd18314

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

40-121

1.62e-14

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349623 [Multi-domain] Cd Length: 96 Bit Score: 69.30 E-value: 1.62e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  40 DVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQF 119
Cdd:cd18314     8 DVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLASKY 87


                  ..
gi 1044873428 120 NI 121
Cdd:cd18314    88 QV 89

BTB2_POZ_BTBD8

cd18286

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

31-137

2.55e-14

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349595 [Multi-domain] Cd Length: 121 Bit Score: 69.60 E-value: 2.55e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  31 ELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPItPDNVE 110
Cdd:cd18286    10 QLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDL-PDDVN 88

                          90       100
                  ....*....|....*....|....*....
gi 1044873428 111 --KLLAAADQFNIMGIVRGCCEFLKSELC 137
Cdd:cd18286    89 lgELLSLADMYGLDGLKDVVAYTLRRDYC 117

BACK_KBTBD12

cd18485

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

140-233

3.59e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.

Pssm-ID: 350560 [Multi-domain] Cd Length: 100 Bit Score: 68.60 E-value: 3.59e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEmVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18485     5 NCLGIYYFAKQIGAEDLSDRARKYLYQHFTE-VCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRKSRV 83

                          90
                  ....*....|....
gi 1044873428 220 QHISILLPKVRLAL 233
Cdd:cd18485    84 QHLVELLKQVRLEL 97

Kelch

Kelch domain;

434-480

4.87e-14

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 66.43 E-value: 4.87e-14

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1044873428  434 KVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGE 480
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB_POZ_ZBTB27-like

cd18215

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-141

1.04e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349524 [Multi-domain] Cd Length: 113 Bit Score: 67.59 E-value: 1.04e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDN 108
Cdd:cd18215    10 LNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDPEIEPEGFRILLDFMYTSRLNLREGN 89

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1044873428 109 VEKLLAAAdqfnimgivrgccEFLKSELCLDNC 141
Cdd:cd18215    90 IMAVMATA-------------MYLQMEHVVDTC 109

BACK

cd14733

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...

137-191

1.12e-13

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.

Pssm-ID: 350515 [Multi-domain] Cd Length: 55 Bit Score: 65.76 E-value: 1.12e-13

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1044873428 137 CLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIE 191
Cdd:cd14733     1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSK-SEEFLELSVELLLELLS 54

BACK_KBTBD6_7

cd18482

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...

136-218

1.19e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.

Pssm-ID: 350557 [Multi-domain] Cd Length: 99 Bit Score: 67.14 E-value: 1.19e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 136 LCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDP 215
Cdd:cd18482     1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFQQLLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANL 80


                  ...
gi 1044873428 216 QNR 218
Cdd:cd18482    81 KER 83

BTB_POZ_ZBTB38_CIBZ

cd18223

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-121

1.47e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349532 [Multi-domain] Cd Length: 114 Bit Score: 67.12 E-value: 1.47e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  28 IFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPIT-P 106
Cdd:cd18223     8 CLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQEIWISSHVLELPDLKAEVFAEILNFIYSSKVVVKrQ 87

                          90
                  ....*....|....*
gi 1044873428 107 DNVEKLLAAADQFNI 121
Cdd:cd18223    88 ETVTDLVAAGKKLGI 102

BTB_POZ_GCL

cd18305

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-133

1.59e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349614 [Multi-domain] Cd Length: 115 Bit Score: 67.31 E-value: 1.59e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  28 IFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSsYFRALFTSGWNNTEKKVYNI----PGISPDMMKLIIEYAYTRTVP 103
Cdd:cd18305     5 IYQTLFLNGENSDITICALGREWKLHKIYLCQSG-YFASMFSGSWKESKETVINLeipdDNITVEALNVVFGSLYRDEIE 83

                          90       100       110
                  ....*....|....*....|....*....|
gi 1044873428 104 ITPDNVEKLLAAADQFNIMGIVRGCCEFLK 133
Cdd:cd18305    84 IKPSRVVSILAAATLLQLDGLIQQCSEVMK 113

Kelch

Kelch domain;

481-527

2.56e-13

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 64.50 E-value: 2.56e-13

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1044873428  481 HVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDD 527
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB_POZ_ZBTB49

cd18233

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-133

3.56e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349542 [Multi-domain] Cd Length: 112 Bit Score: 66.07 E-value: 3.56e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALF--TSGWNNT--EKKVYNIPGISPdmmklIIEYAYTRTVPI 104
Cdd:cd18233     9 LHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFqnSSSQKNDvfHLDIKNVGGIGQ-----ILDFMYTSHLDL 83

                          90       100
                  ....*....|....*....|....*....
gi 1044873428 105 TPDNVEKLLAAADQFNIMGIVRGCCEFLK 133
Cdd:cd18233    84 NQDNVQVMLDIAQCLQVQNVLNMCYTFLK 112

BTB_POZ

cd01165

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

41-116

4.33e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

Pssm-ID: 349496 [Multi-domain] Cd Length: 79 Bit Score: 64.61 E-value: 4.33e-13

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1044873428  41 VVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAA 116
Cdd:cd01165     1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAA 76

BTB_POZ_BTBD19

cd18294

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

37-132

6.11e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349603 [Multi-domain] Cd Length: 111 Bit Score: 65.34 E-value: 6.11e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  37 KLCDVVIKV--NGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYN-IPGISPDMMKLIIEYAYTRTVPITPDNVEKLL 113
Cdd:cd18294    13 EFSDVKFLVgpERQEIFAHKCILAARCEVFRAMFLTGPQKESTQSPLvLSDIEPEVFRAVLEFIYTNCVTLSNHTVIEVL 92

                          90
                  ....*....|....*....
gi 1044873428 114 AAADQFNIMGIVRGCCEFL 132
Cdd:cd18294    93 AAAVEYGLDELRKLCERFI 111

Kelch

Kelch domain;

341-386

7.43e-13

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 62.96 E-value: 7.43e-13

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1044873428  341 VYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGN 386
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BACK_KLHL21

cd18460

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...

136-231

7.75e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.

Pssm-ID: 350535 [Multi-domain] Cd Length: 101 Bit Score: 64.82 E-value: 7.75e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 136 LCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDP 215
Cdd:cd18460     1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAK-GEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADP 79

                          90
                  ....*....|....*.
gi 1044873428 216 QNRKQHISILLPKVRL 231
Cdd:cd18460    80 KHRQHFWPELLQHVRL 95

BACK_KLHL37_ENC1

cd18515

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...

140-234

9.00e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.

Pssm-ID: 350590 [Multi-domain] Cd Length: 98 Bit Score: 64.61 E-value: 9.00e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18515     4 NCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICK-TEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKRH 82

                          90
                  ....*....|....*
gi 1044873428 220 QHISILLPKVRLALM 234
Cdd:cd18515    83 CYLSELLQTVRLALL 97

BTB_POZ_ZBTB48_TZAP_KR3

cd18232

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-131

1.18e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349541 [Multi-domain] Cd Length: 108 Bit Score: 64.39 E-value: 1.18e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTekkvYNIPGISPDMMKLIIEYAYTRTVPITPDNV 109
Cdd:cd18232    10 NKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGS----VVLPESFAEVFGLLLDFFYTGELALTRENR 85

                          90       100
                  ....*....|....*....|..
gi 1044873428 110 EKLLAAADQFNIMGIVRGCCEF 131
Cdd:cd18232    86 DRVLLAAKELRVPEAVELCQRF 107

BTB_POZ_ZBTB32_FAZF_TZFP

cd18218

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-133

1.23e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349527 [Multi-domain] Cd Length: 110 Bit Score: 64.57 E-value: 1.23e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  31 ELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTsgwNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVE 110
Cdd:cd18218    11 RLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLT---NPNPGQWCLGEGISPSTFKQLLDFVYGESVEVQPGELR 87

                          90       100
                  ....*....|....*....|...
gi 1044873428 111 KLLAAADQFNIMGIVRGCCEFLK 133
Cdd:cd18218    88 PLLEAARALEVESLEEACWRALG 110

BACK_KLHL27_IPP

cd18466

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...

140-234

1.30e-12

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.

Pssm-ID: 350541 [Multi-domain] Cd Length: 103 Bit Score: 64.04 E-value: 1.30e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEmVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRK 219
Cdd:cd18466     5 NCIGIFQFSEQIACHDLLEFTENYIHVHFLE-VQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKRK 83

                          90
                  ....*....|....*
gi 1044873428 220 QHISILLPKVRLALM 234
Cdd:cd18466    84 KHVVEVLEPVRFPLL 98

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

375-419

1.33e-12

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 62.24 E-value: 1.33e-12

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1044873428 375 RRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPM 419
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45

BTB_POZ_ZBTB5

cd18196

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-134

1.47e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349505 [Multi-domain] Cd Length: 126 Bit Score: 64.68 E-value: 1.47e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  27 EIFNEL---RLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPG--ISPDMMKLIIEYAYTRT 101
Cdd:cd18196     7 QIFQQLnyqRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTVAEGDQTMNMIQLDSevVTAEAFAALIDMMYTST 86

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1044873428 102 VPITPDNVEKLLAAADQFNIMGIVRGCCEFLKS 134
Cdd:cd18196    87 LMLGESNVMDVLLAASHLHLNSVVKACKHYLTT 119

BTB_POZ_KLHL14_printor

cd18243

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

39-140

1.77e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349552 [Multi-domain] Cd Length: 130 Bit Score: 64.68 E-value: 1.77e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  39 CDVVIKVNGFEFSAHKNILCSCSSYFRALFTSgwNNTEKKVYNIPGIspdmmKLIIEYAYTRTVPITPDNVEKLLAAADQ 118
Cdd:cd18243    33 CDVTLTAQGQQFHCHKAVLASCSQYFRSLFSI--NNLVLQGCSSIGL-----RLVLEYLYTANVTLSLDTVEEVLSVSKI 105

                          90       100
                  ....*....|....*....|..
gi 1044873428 119 FNIMGIVRGCCEFLKSELCLDN 140
Cdd:cd18243   106 LHIPQVTKLCVQFLNDQISVQN 127

BTB_POZ_BTBD14B_NAC1

cd18290

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-131

1.81e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349599 [Multi-domain] Cd Length: 123 Bit Score: 64.29 E-value: 1.81e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  27 EIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFtsgwNNTEKKVYNIPG-ISPDMMKLIIEYAYTRTVPIT 105
Cdd:cd18290    16 ECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLF----NSSRSAVVELPAaVQPQSFQQILSFCYTGRLSMN 91

                          90       100
                  ....*....|....*....|....*.
gi 1044873428 106 PDNVEKLLAAADQFNIMGIVRGCCEF 131
Cdd:cd18290    92 VGDQFLLMYTAGFLQIQEIMEKGTEF 117

BTB_POZ_ZBTB16_PLZF

cd18205

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-132

1.89e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349514 [Multi-domain] Cd Length: 107 Bit Score: 63.90 E-value: 1.89e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFtsgwnNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNV 109
Cdd:cd18205    10 NQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILF-----HRNSQHYTLDFLSPKTFQQILEYAYTATLQAKVEDL 84

                          90       100
                  ....*....|....*....|...
gi 1044873428 110 EKLLAAADQFNIMGIVRGCCEFL 132
Cdd:cd18205    85 DDLLYAAEILEIEYLEEQCLKIL 107

BTB_POZ_BTBD9

cd18287

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-132

2.54e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349596 [Multi-domain] Cd Length: 119 Bit Score: 63.79 E-value: 2.54e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPIT--- 105
Cdd:cd18287    13 IGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYTGRLTLTdlk 92

                          90       100
                  ....*....|....*....|....*..
gi 1044873428 106 PDNVEKLLAAADQFNIMGIVRGCCEFL 132
Cdd:cd18287    93 EDVLLDVLGLAHQYGFEELEAAISDYL 119

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

423-467

2.59e-12

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 61.47 E-value: 2.59e-12

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1044873428 423 RSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMR 467
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_KBTBD4

cd18272

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

35-144

3.30e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349581 [Multi-domain] Cd Length: 140 Bit Score: 64.15 E-value: 3.30e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  35 EGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLA 114
Cdd:cd18272    29 DGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRVEELQETYE 108

                          90       100       110
                  ....*....|....*....|....*....|
gi 1044873428 115 AADQFNIMGIVRGCCEFLKSELCLDNCIGI 144
Cdd:cd18272   109 VADMYQLTALFEECSRFLARTVQVRNCLQV 138

BTB_POZ_BTBD17

cd18292

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

26-131

3.62e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349601 [Multi-domain] Cd Length: 114 Bit Score: 63.46 E-value: 3.62e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  26 CEIFNElrleGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTS-GWNNTEKKV--YNIPGISPDMMKLIIEYAYTRTV 102
Cdd:cd18292     9 AQLYNN----EELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNdWWSESKQSEieLVEDPECAAVFEKFLRYLYTGQI 84

                          90       100
                  ....*....|....*....|....*....
gi 1044873428 103 PITPDNVEKLLAAADQFNIMGIVRGCCEF 131
Cdd:cd18292    85 SVNLETALPLLMLADKYNVTDLKQLCVDF 113

BTB_POZ_ZBTB10

cd18201

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-136

3.73e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349510 [Multi-domain] Cd Length: 122 Bit Score: 63.44 E-value: 3.73e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRAL--FTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITP 106
Cdd:cd18201    12 LNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLycFTNKESCDQTTVTHLDVVAVQGFSVILDFMYSGNLVLTS 91

                          90       100       110
                  ....*....|....*....|....*....|
gi 1044873428 107 DNVEKLLAAADQFNIMGIVRGCCEFLKSEL 136
Cdd:cd18201    92 QNAIEVMSVASYLQMTEVVQSCRNFIKDAL 121

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

328-372

4.84e-12

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 60.70 E-value: 4.84e-12

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1044873428 328 PRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPM 372
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

469-513

8.20e-12

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 59.93 E-value: 8.20e-12

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1044873428 469 RRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTM 513
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45

Kelch

Kelch domain;

388-433

8.88e-12

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 59.88 E-value: 8.88e-12

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1044873428  388 IYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYG 433
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB_POZ_ZBTB21_ZNF295

cd18209

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-102

9.64e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349518 [Multi-domain] Cd Length: 112 Bit Score: 62.20 E-value: 9.64e-12

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGwNNTEKKVYNIPGISPDMMKLIIEYAYTRTV 102
Cdd:cd18209     9 LNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEK-ENESQSVFQLDFCEPDAFENVLNYIYSSSL 81

BTB_POZ_KBTBD11

cd18275

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

40-141

9.87e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349584 [Multi-domain] Cd Length: 104 Bit Score: 61.73 E-value: 9.87e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  40 DVVIKVNGFEFSAHKNILCSCSSYFRAlftsgwnNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQF 119
Cdd:cd18275     6 DLVIEVSGQRIRAHKSVLAAKSDYFRA-------RLSRDILKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFL 78

                          90       100
                  ....*....|....*....|..
gi 1044873428 120 NIMGIVRGCCEFLKSELCLDNC 141
Cdd:cd18275    79 QMPCAAQCAVDAVRAQLCLGNC 100

PLN02193

nitrile-specifier protein

376-554

1.33e-11

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 66.90 E-value: 1.33e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 376 RCYVSVTVLGNFIYAMGG-------FDGYVRLntaerYEPETNQWTlIAPM-----HEQRSDASATTLYGKVYICGGFNG 443
Cdd:PLN02193  166 RCSHGIAQVGNKIYSFGGeftpnqpIDKHLYV-----FDLETRTWS-ISPAtgdvpHLSCLGVRMVSIGSTLYVFGGRDA 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 444 NECLFTAEVYNTESNQWTVIAPMR---SRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPT---MFNPR 517
Cdd:PLN02193  240 SRQYNGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHCSTpgdSFSIR 319

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1044873428 518 SNFGIEVVDDLLFVVGGFNGFTTTfNVECYDEKTDEW 554
Cdd:PLN02193  320 GGAGLEVVQGKVWVVYGFNGCEVD-DVHYYDPVQDKW 355

BTB_POZ_KBTBD3_BKLHD3

cd18271

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

28-144

1.84e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349580 [Multi-domain] Cd Length: 130 Bit Score: 61.77 E-value: 1.84e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  28 IFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPD 107
Cdd:cd18271    14 VLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKAEITDD 93

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1044873428 108 NVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGI 144
Cdd:cd18271    94 NVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCLQL 130

BTB_POZ_BPM_plant

cd18280

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

39-137

2.45e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349589 [Multi-domain] Cd Length: 121 Bit Score: 61.19 E-value: 2.45e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  39 CDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVP-----------ITPD 107
Cdd:cd18280    15 ADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYKDELPddvepagsdssSLDT 94

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1044873428 108 NV-EKLLAAADQFNIMGIvRGCCEflkSELC 137
Cdd:cd18280    95 TMaQHLLAAADRYALERL-RLLCE---SRLC 121

BTB_POZ_KBTBD12

cd18276

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-144

2.45e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349585 [Multi-domain] Cd Length: 127 Bit Score: 61.36 E-value: 2.45e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGW---NNTEKKVYNIPGISpdmMKLIIEYAYTRTVPITP 106
Cdd:cd18276    13 NRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLmecSQREVVLHDITAES---VSIILNYMYSSDLHLTN 89

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1044873428 107 DNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGI 144
Cdd:cd18276    90 SNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127

PLN02193

nitrile-specifier protein

317-534

2.96e-11

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 65.75 E-value: 2.96e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 317 RWVNVTCEEESP--RAYHGAAYLKGYVYIIGG----FDSVDYFNSVkrFDPVKKTWhQVAPM-----HSRRCYVSVTVLG 385
Cdd:PLN02193  152 KWIKVEQKGEGPglRCSHGIAQVGNKIYSFGGeftpNQPIDKHLYV--FDLETRTW-SISPAtgdvpHLSCLGVRMVSIG 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 386 NFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHE---QRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQW-- 460
Cdd:PLN02193  229 STLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEgptPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWfh 308

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1044873428 461 -TVIAPMRSRRSGIGVIAYGEHVYAVGGFDGAnRLRSAEAYSPVANTWRTIPTMF---NPRSNFGIEVVDDLLFVVGG 534
Cdd:PLN02193  309 cSTPGDSFSIRGGAGLEVVQGKVWVVYGFNGC-EVDDVHYYDPVQDKWTQVETFGvrpSERSVFASAAVGKHIVIFGG 385

BTB_POZ_ZBTB34

cd18220

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-134

3.93e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349529 [Multi-domain] Cd Length: 120 Bit Score: 60.42 E-value: 3.93e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFR---ALFT-SGWNNTEKKvynipgiSPDMMKLIIEYAYTRTVPI 104
Cdd:cd18220    16 LNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRdhsALSTmSGLSISVIK-------NPNVFEQLLSFCYTGRMSL 88

                          90       100       110
                  ....*....|....*....|....*....|
gi 1044873428 105 TPDNVEKLLAAADQFNIMGIVRGCCEFLKS 134
Cdd:cd18220    89 QLKDVVSFLTAASFLQMQCVIDKCTQILES 118

BTB_POZ_ZBTB14

cd18204

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-124

5.51e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349513 [Multi-domain] Cd Length: 114 Bit Score: 60.05 E-value: 5.51e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  27 EIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEkKVYNIPGISPDMMKLIIEYAYTRTVPITP 106
Cdd:cd18204     7 KTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSS-SVIEIDFLRSDIFEEVLNYMYTAKISVKK 85

                          90
                  ....*....|....*...
gi 1044873428 107 DNVEKLLAAAdqfNIMGI 124
Cdd:cd18204    86 EDVNLMMSSG---QILGI 100

BTB_POZ_ZBTB19_PATZ1

cd18207

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

36-133

6.22e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349516 [Multi-domain] Cd Length: 128 Bit Score: 60.36 E-value: 6.22e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  36 GKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTS-GWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLA 114
Cdd:cd18207    25 GRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAqEGDGGTPRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMT 104

                          90
                  ....*....|....*....
gi 1044873428 115 AADQFNIMGIVRGCCEFLK 133
Cdd:cd18207   105 AAKFLLMRSVIDICQEVIK 123

BTB_POZ_BTBD18

cd18293

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

36-130

8.04e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349602 [Multi-domain] Cd Length: 120 Bit Score: 59.80 E-value: 8.04e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  36 GKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWN-NTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLA 114
Cdd:cd18293    13 GVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPpAGQKVVLELQGLKAHTLLKLVDFLYTSELEVSSEEAQDVLA 92

                          90
                  ....*....|....*.
gi 1044873428 115 AADQFNIMGIVRGCCE 130
Cdd:cd18293    93 AARRLQISELESLCLE 108

BTB2_POZ_IBtk

cd18302

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

38-136

1.21e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349611 [Multi-domain] Cd Length: 113 Bit Score: 58.91 E-value: 1.21e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  38 LCDVVIK-VNGFEFSAHKNILCSCSSYFRALFTSGW-NNTEKKVYNIPgISPDMMKLIIEYAYTRTVPITPD--NVEKL- 112
Cdd:cd18302     5 LYDVTIVsEDGKEFPCHKCVLVARLEYFHSMLSSSWiEASSCSALTMP-IPSDILEIILDYLYTDEASAVKEsqNVEFLc 83

                          90       100
                  ....*....|....*....|....*.
gi 1044873428 113 --LAAADQFNIMGIVRgCCEFLKSEL 136
Cdd:cd18302    84 nvLVIADQLLITRLKE-ICEVALVEL 108

BTB_POZ_BACH1

cd18277

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-132

1.24e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349586 [Multi-domain] Cd Length: 120 Bit Score: 59.31 E-value: 1.24e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFT----SGWNNTEKKVYNIPGISPdmmklIIEYAYTRTVPI 104
Cdd:cd18277    18 LNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVgqadAELNITLPEEVTVKGFEP-----LIQFAYTAKLIL 92

                          90       100
                  ....*....|....*....|....*...
gi 1044873428 105 TPDNVEKLLAAADQFNIMGIVRGCCEFL 132
Cdd:cd18277    93 SKDNVDEVCKCVEFLSVHNIEESCFQFL 120

BTB2_POZ_RhoBTB

cd18300

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

35-136

1.41e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349609 [Multi-domain] Cd Length: 108 Bit Score: 58.40 E-value: 1.41e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  35 EGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDN-VEKLL 113
Cdd:cd18300     6 KGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPILEDGdCVGLI 85

                          90       100
                  ....*....|....*....|...
gi 1044873428 114 AAADQFNIMGIVRGCCEFLKSEL 136
Cdd:cd18300    86 VLANRLCLPRLVALCEQYIVKEL 108

BTB_POZ_SPOP-like

cd18279

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

37-140

1.85e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349588 [Multi-domain] Cd Length: 120 Bit Score: 58.69 E-value: 1.85e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  37 KLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAA 116
Cdd:cd18279    17 RFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADDLLAAA 96

                          90       100
                  ....*....|....*....|....
gi 1044873428 117 DQFNIMGIVRGCCEFLKSELCLDN 140
Cdd:cd18279    97 DKYALERLKVMCEDALCSNLSVEN 120

BTB_POZ_SPOPL

cd18343

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

37-140

1.87e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349652 [Multi-domain] Cd Length: 123 Bit Score: 58.86 E-value: 1.87e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  37 KLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAA 116
Cdd:cd18343    20 RFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADNLLAAA 99

                          90       100
                  ....*....|....*....|....
gi 1044873428 117 DQFNIMGIVRGCCEFLKSELCLDN 140
Cdd:cd18343   100 DKYALERLKVMCEEALCNNLSVEN 123

BACK_KLHL35

cd18474

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...

140-215

2.05e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.

Pssm-ID: 350549 [Multi-domain] Cd Length: 79 Bit Score: 57.13 E-value: 2.05e-10

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDP 215
Cdd:cd18474     5 NCLALLAAADALHCAPLQEHCIRVLLRDFAQAAR-HPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDADP 79

Kelch

Kelch domain;

528-574

2.80e-10

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 55.64 E-value: 2.80e-10

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1044873428  528 LLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPG 574
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB_POZ_ZBTB8A_BOZF1

cd18329

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

13-132

2.99e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349638 [Multi-domain] Cd Length: 116 Bit Score: 57.91 E-value: 2.99e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  13 HQPHMERKMsamaceifNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNT-EKKVYNIPGISPDMMK 91
Cdd:cd18329     4 HQSRLLQQL--------DEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETgQPTVATFDVFSPDTFT 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1044873428  92 LIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFL 132
Cdd:cd18329    76 IILDFVYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116

BTB1_POZ_IBtk

cd18301

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

40-101

3.55e-10

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349610 [Multi-domain] Cd Length: 99 Bit Score: 57.30 E-value: 3.55e-10

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1044873428  40 DVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKV----YNIPGISPDMMKLIIEYAYTRT 101
Cdd:cd18301    20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTSEDAVgcdvVHIEKVPPEIFEQLLQFIYTDT 85

BTB_POZ_ZBTB1

cd18192

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-115

4.42e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349501 [Multi-domain] Cd Length: 114 Bit Score: 57.52 E-value: 4.42e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNV 109
Cdd:cd18192    13 NNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSNMKISAECFDLILQFMYLGKIMTAPSDF 92


                  ....*.
gi 1044873428 110 EKLLAA 115
Cdd:cd18192    93 EQLKVA 98

BTB_POZ_ZBTB27_BCL6

cd18331

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-132

4.80e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349640 [Multi-domain] Cd Length: 118 Bit Score: 57.56 E-value: 4.80e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDN 108
Cdd:cd18331    15 LNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFNILLDFMYTSRLNLREGN 94

                          90       100
                  ....*....|....*....|....
gi 1044873428 109 VEKLLAAADQFNIMGIVRGCCEFL 132
Cdd:cd18331    95 IMAVMATAMYLQMEHVVDTCRKFI 118

BTB_POZ_BTBD14A_NAC2

cd18289

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-122

5.01e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349598 [Multi-domain] Cd Length: 131 Bit Score: 57.73 E-value: 5.01e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFtsgwNNTEKKVYNIPG-ISPDMMKLIIEYAYTRTVPitpd 107
Cdd:cd18289    20 LNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLF----SGNSKSAFELPAtVPPACFQQILSFCYTGKLT---- 91

                          90
                  ....*....|....*
gi 1044873428 108 nveklLAAADQFNIM 122
Cdd:cd18289    92 -----MAASEQLVVM 101

BTB_POZ_ZBTB29_HIC1

cd18333

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-133

5.78e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349642 [Multi-domain] Cd Length: 121 Bit Score: 57.22 E-value: 5.78e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFtsgwnnTEKKVYNIPG--ISPDMMKLIIEYAYTRTV---- 102
Cdd:cd18333    12 LNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLV------VHDNLINLDHemVSPGIFRLILDYIYTGRLsegd 85

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1044873428 103 PITPDNVEKLLAAADQFNIMGIVRGCCEFLK 133
Cdd:cd18333    86 PGSEQNLGAVLAAASYLQIPDLVALCKKKLK 116

BTB_POZ_ZBTB33_KAISO

cd18219

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-121

7.18e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349528 [Multi-domain] Cd Length: 106 Bit Score: 56.38 E-value: 7.18e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTsgwnnTEKKVYNIPGISPDMMKLIIEYAYT-RTVPITPDN 108
Cdd:cd18219    13 NEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFS-----VAGQVVELNFIRADIFAEILNYIYSsKIVRVRSDL 87

                          90
                  ....*....|...
gi 1044873428 109 VEKLLAAADQFNI 121
Cdd:cd18219    88 LEELIKSGQLLGV 100

BTB_POZ_ZBTB40

cd18225

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

32-134

7.75e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349534 [Multi-domain] Cd Length: 116 Bit Score: 56.76 E-value: 7.75e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  32 LRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFtsgwNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEK 111
Cdd:cd18225    17 LRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLL----DSTDTISIDASVVSPEEFALLLEMVYTGKLPPGKHNFTK 92

                          90       100
                  ....*....|....*....|...
gi 1044873428 112 LLAAADQFNIMGIVRGCCEFLKS 134
Cdd:cd18225    93 IISVADSLQMFDVAVSCKNLLTS 115

BTB_POZ_BTBD1_2

cd18281

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

52-140

8.78e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349590 [Multi-domain] Cd Length: 127 Bit Score: 57.06 E-value: 8.78e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  52 AHKNILCSCSSYFRALFTSGWNNTEKKVyNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEF 131
Cdd:cd18281    40 AHKFVLSIGSAVFDAMFNGGMATTSAEI-ELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEF 118


                  ....*....
gi 1044873428 132 LKSELCLDN 140
Cdd:cd18281   119 LKKNLSSDN 127

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

516-561

1.13e-09

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 54.16 E-value: 1.13e-09

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1044873428 516 PRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMS 561
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_ZBTB37

cd18222

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-133

1.20e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349531 [Multi-domain] Cd Length: 123 Bit Score: 56.59 E-value: 1.20e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGwnntEKKVYNIPGI-SPDMMKLIIEYAYTRTVPITPD 107
Cdd:cd18222    16 LNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLN----EMSTVSISVIkNPTVFEQLLSFCYTGRICLQLA 91

                          90       100
                  ....*....|....*....|....*.
gi 1044873428 108 NVEKLLAAADQFNIMGIVRGCCEFLK 133
Cdd:cd18222    92 DIISYLTAASFLQMQHIIDKCTQILE 117

BTB_POZ_ZBTB11

cd18202

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-99

1.25e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349511 [Multi-domain] Cd Length: 118 Bit Score: 56.01 E-value: 1.25e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1044873428  30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTS-GWNNTEKKVYNIPGISPDMMKLIIEYAYT 99
Cdd:cd18202    11 NQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEkGAVSSHEAVVDLSGFCKSSFLPLLEFAYT 81

BTB_POZ_ZBTB31_myoneurin

cd18217

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-128

1.30e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349526 [Multi-domain] Cd Length: 111 Bit Score: 55.92 E-value: 1.30e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  27 EIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTekKVYNIPGISPDMMKLIIEYAYTRTVPITP 106
Cdd:cd18217     7 ERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNI--VFLDQSQVSADGFQKLLEFIYTGNLNLDS 84

                          90       100
                  ....*....|....*....|..
gi 1044873428 107 DNVEKLLAAADQFNIMGIVRGC 128
Cdd:cd18217    85 WNVAEIHQAASYLGMEEVVAKC 106

BACK_KLHL34

cd18473

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...

136-237

1.32e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.

Pssm-ID: 350548 Cd Length: 106 Bit Score: 55.90 E-value: 1.32e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 136 LCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKV---SAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWIS 212
Cdd:cd18473     1 LSPENCCFSANIAARFGLPDALKAAEKYIISNLWRLLASdadDAGLLELNLESLQAVLEADDIPRVKESRLLTLVLEWLN 80

                          90       100
                  ....*....|....*....|....*
gi 1044873428 213 HDPQnRKQHISILLPKVRLALMHAE 237
Cdd:cd18473    81 QDES-RLAYANALLSRIRYGLVPVE 104

BTB_POZ_ZBTB8

cd18199

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-132

2.61e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349508 [Multi-domain] Cd Length: 113 Bit Score: 55.12 E-value: 2.61e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEK-KVYNIPGISPDMMKLIIEYAYTRTVPITPDN 108
Cdd:cd18199    10 NEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRpSTASFDVFSSDAFSIILDFVYSGKLSLTSQN 89

                          90       100
                  ....*....|....*....|....
gi 1044873428 109 VEKLLAAADQFNIMGIVRGCCEFL 132
Cdd:cd18199    90 VIEVMSAASYLQMTDVINVCKTFI 113

BTB_POZ_ZBTB18_2-like

cd18325

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-140

3.23e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349634 [Multi-domain] Cd Length: 128 Bit Score: 55.43 E-value: 3.23e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  27 EIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITP 106
Cdd:cd18325    12 QCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQLDKRDIVHLNSDIVTAPAFSLLLEFMYEGKLEFSS 91

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1044873428 107 DNVEKLLAAADQFNIMGIVRGCCEFLK-SELCLDN 140
Cdd:cd18325    92 LPVEDVLAAASYLHMYDIVKVCKGKLKdKELCSEE 126

BTB_POZ_RCBTB1_2

cd18298

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

40-133

3.62e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349607 [Multi-domain] Cd Length: 108 Bit Score: 54.57 E-value: 3.62e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  40 DVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQF 119
Cdd:cd18298    14 DLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPPEDAIGLLDLANSY 93

                          90
                  ....*....|....
gi 1044873428 120 NIMGIVRGCCEFLK 133
Cdd:cd18298    94 CEERLKKLCEDIIK 107

BTB_POZ_BTBD3_6

cd18282

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

52-136

3.95e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349591 [Multi-domain] Cd Length: 108 Bit Score: 54.32 E-value: 3.95e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  52 AHKNILCSCSSYFRALFTSGWNNTEKKVYnIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEF 131
Cdd:cd18282    25 AHKYVLATGSSVFYAMFYGGLAENKNEIE-IPDVEPAAFLNLLRYLYCDEIDLEPDTVLATLYAAKKYLVPHLARACVQF 103


                  ....*
gi 1044873428 132 LKSEL 136
Cdd:cd18282   104 LETSL 108

BTB_POZ_ZBTB18_RP58

cd18324

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-135

4.03e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349633 [Multi-domain] Cd Length: 147 Bit Score: 55.43 E-value: 4.03e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  27 EIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITP 106
Cdd:cd18324    12 QCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLEFMYEGKLQFKD 91

                          90       100
                  ....*....|....*....|....*....
gi 1044873428 107 DNVEKLLAAADQFNIMGIVRGCCEFLKSE 135
Cdd:cd18324    92 LPIEDVLAAASYLHMYDIVKVCKKKLKEK 120

BTB_POZ_roadkill-like

cd18345

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

37-140

4.14e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349654 [Multi-domain] Cd Length: 121 Bit Score: 54.85 E-value: 4.14e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  37 KLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAA 116
Cdd:cd18345    17 AFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGKAPNLDKMADDLLAAA 96

                          90       100
                  ....*....|....*....|....
gi 1044873428 117 DQFNIMGIVRGCCEFLKSELCLDN 140
Cdd:cd18345    97 DKYALERLKVMCEEALCSNLSVEN 120

BTB_POZ_BACH

cd18955

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

38-132

5.54e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349736 [Multi-domain] Cd Length: 94 Bit Score: 53.63 E-value: 5.54e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  38 LCDVVIKVNGFEFSAHKNILCSCSSYFRAlfTSGWNNTEKKVYNIP------GISPdmmklIIEYAYTRTVPITPDNVEK 111
Cdd:cd18955     1 LCDVTIVVEDQRFRAHRAVLAACSDYFLS--RVVGQTDGDLVITLPeevtvkGFEP-----LLQFAYTAKLLLSKENVLE 73

                          90       100
                  ....*....|....*....|.
gi 1044873428 112 LLAAADQFNIMGIVRGCCEFL 132
Cdd:cd18955    74 VCRCAEFLGVHNIEKACFDFL 94

BTB_POZ_ZBTB24_ZNF450

cd18212

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-126

6.31e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349521 [Multi-domain] Cd Length: 118 Bit Score: 54.03 E-value: 6.31e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGwNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDN 108
Cdd:cd18212    14 FEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADE-GEVGQSIYMLEGMVAETFGALLEFIYTGCLQVGEKS 92

                          90
                  ....*....|....*...
gi 1044873428 109 VEKLLAAADQFNIMGIVR 126
Cdd:cd18212    93 LEQILATAQFLKVNDLVK 110

BTB_POZ_BACH2

cd18278

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-132

1.01e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349587 [Multi-domain] Cd Length: 124 Bit Score: 53.80 E-value: 1.01e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEkkVYNIP------GISPdmmklIIEYAYTRTV 102
Cdd:cd18278    22 LNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENDL--VVSLPeevtarGFGP-----LLQFAYTAKL 94

                          90       100       110
                  ....*....|....*....|....*....|
gi 1044873428 103 PITPDNVEKLLAAADQFNIMGIVRGCCEFL 132
Cdd:cd18278    95 LLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124

BTB_POZ_ZBTB22_BING1

cd18210

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-132

1.04e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349519 [Multi-domain] Cd Length: 112 Bit Score: 53.31 E-value: 1.04e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  27 EIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYF--RALFtsgwNNTEKKVynIPGI-SPDMMKLIIEYAYTRTVP 103
Cdd:cd18210    10 ESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFhdQVLL----KNMSSIS--LPGVmDPGAFESVLASAYTGKLT 83

                          90       100
                  ....*....|....*....|....*....
gi 1044873428 104 ITPDNVEKLLAAADQFNIMGIVRGCCEFL 132
Cdd:cd18210    84 MLADEIVNYLTVGSVLQMWHIVDKCTELL 112

BACK_KLHL11

cd18451

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...

136-221

1.09e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.

Pssm-ID: 350526 [Multi-domain] Cd Length: 88 Bit Score: 52.66 E-value: 1.09e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 136 LCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDP 215
Cdd:cd18451     1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQ-DEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNA 79


                  ....*.
gi 1044873428 216 QNRKQH 221
Cdd:cd18451    80 EERERY 85

BACK_KLHL33

cd18472

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...

139-210

1.57e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.

Pssm-ID: 350547 [Multi-domain] Cd Length: 75 Bit Score: 51.62 E-value: 1.57e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1044873428 139 DNCIGICKFTDYYYCPELRQKAYMFILHNFEEmVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKW 210
Cdd:cd18472     4 ANCLELWAFADAATLPRLAAAARAFALKHFAE-VAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRW 74

BACK_KLHL15

cd18454

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a ...

136-234

1.69e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for Cullin3 E3 ubiquitin-protein ligase complex that target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation.

Pssm-ID: 350529 Cd Length: 108 Bit Score: 52.59 E-value: 1.69e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 136 LCLDNCIGICKFTDYYYC--PELRQKAYMFILHNFEEMVKvSAEFLE-LSVTELKDIIEKDELNVKQEDAVFEAILKWIS 212
Cdd:cd18454     1 ICLDNCAEIMRLLDDFSVniEGVREKLDSFLLENFVPLMS-RPDFLSyLSFEKLMSYLDNDHLSRFPEIELYEAVQAWLR 79

                          90       100
                  ....*....|....*....|..
gi 1044873428 213 HDpQNRKQHISILLPKVRLALM 234
Cdd:cd18454    80 HD-RRRWRHTDTIIQNIRFCLM 100

BTB1_POZ_ABTB1_BPOZ1

cd18295

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

36-118

2.01e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349604 [Multi-domain] Cd Length: 119 Bit Score: 52.64 E-value: 2.01e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  36 GKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNteKKVYNI--PGISPDMMKLIIEYAYTRTVPITPDNVEKLL 113
Cdd:cd18295    17 GSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKD--KREINLkhPLVNPDAFRALLQYLYTGRLEIHVDDVEDCK 94


                  ....*
gi 1044873428 114 AAADQ 118
Cdd:cd18295    95 RLAKQ 99

BTB_POZ_NPY3-like

cd18312

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

33-117

2.06e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349621 [Multi-domain] Cd Length: 105 Bit Score: 52.33 E-value: 2.06e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  33 RLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRAL--FTSGWNNTEKKVYNIPGiSPDMMKLIIEYAYTRTVPITPDNVE 110
Cdd:cd18312     4 RDTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLasSSSESDPSEIELNDFPG-GAEAFELVAKFCYGMPINLTATNVV 82


                  ....*..
gi 1044873428 111 KLLAAAD 117
Cdd:cd18312    83 GLRCAAE 89

BACK_calicin

cd18503

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...

136-213

2.34e-08

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.

Pssm-ID: 350578 [Multi-domain] Cd Length: 78 Bit Score: 51.19 E-value: 2.34e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1044873428 136 LCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEmVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISH 213
Cdd:cd18503     1 LDRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFD-VSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77

BTB_POZ_ZBTB4

cd18195

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-116

2.43e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349504 [Multi-domain] Cd Length: 124 Bit Score: 52.59 E-value: 2.43e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTS-------------GWNNTEKKVYNIPGISPDMMKLIIEY 96
Cdd:cd18195    10 NEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSplplgaaavaaapGATQSPERVLELPGVKAGVFSDVLNF 89

                          90       100
                  ....*....|....*....|
gi 1044873428  97 AYTRTVPITPDNVEKLLAAA 116
Cdd:cd18195    90 IYSSRVALPGSAAAKELGAA 109

BTB_POZ_ZBTB8B

cd18330

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-128

3.08e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349639 [Multi-domain] Cd Length: 113 Bit Score: 52.24 E-value: 3.08e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEK-KVYNIPGISPDMMKLIIEYAYTRTVPITPD 107
Cdd:cd18330     9 LNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRhSTASLDIVTSEAFSIILDFLYSGKLDLCSE 88

                          90       100
                  ....*....|....*....|.
gi 1044873428 108 NVEKLLAAADQFNIMGIVRGC 128
Cdd:cd18330    89 NVIEVMSAASYLQMTDVVNFC 109

BTB_POZ_ZBTB9

cd18200

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

22-133

3.09e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349509 [Multi-domain] Cd Length: 111 Bit Score: 52.16 E-value: 3.09e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  22 SAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTsgWNNTEKKVynIPG-ISPDMMKLIIEYAYTR 100
Cdd:cd18200     2 SSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDKLL--LNDTNCLV--LPSvIEAAAFENLLQLIYSG 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1044873428 101 TVPITPDNVEKLLAAADQFNIMGIVRGCCEFLK 133
Cdd:cd18200    78 RLTLCMDALPSHLLVASGLQMWQVVDRCSELLK 110

BTB_POZ_ZBTB3

cd18323

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-128

4.83e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349632 [Multi-domain] Cd Length: 128 Bit Score: 51.75 E-value: 4.83e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  31 ELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVE 110
Cdd:cd18323    16 EQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFHMFYKEQLDKRDLVCINNEIVTAPAFSLLLEFMYEGRLSFNDTPVE 95

                          90
                  ....*....|....*...
gi 1044873428 111 KLLAAADQFNIMGIVRGC 128
Cdd:cd18323    96 DVLAAASYLHMNDIVKVC 113

BTB_POZ_ZBTB23_GZF1

cd18211

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

17-136

5.44e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349520 [Multi-domain] Cd Length: 128 Bit Score: 51.78 E-value: 5.44e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  17 MERKMSAMacEIFNE---LRLEGKLCDVVIKVN----GFEFSAHKNILCSCSSYFRALF-TSGWNNTEKKVYNIPGISPD 88
Cdd:cd18211     3 LESKSAPS--NLLNEmhkLRLLGHLCDVTVQVEhqgsKEEFSAHKAVLAASSKYFKEVFlNEKISDGKNTNVMLNEIYTA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1044873428  89 MMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRgCCEFLKSEL 136
Cdd:cd18211    81 DFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDLSE-TCFQLKKQM 127

BTB1_POZ_RhoBTB

cd18299

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

34-121

5.60e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349608 [Multi-domain] Cd Length: 103 Bit Score: 51.06 E-value: 5.60e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  34 LEGKLC-DVVIKVNGFE-FSAHKNILCSCSSYFRALFtsgwnNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEK 111
Cdd:cd18299     7 LHSPSCaDVVFILQGGVrIFAHRIVLAAASSVFADLF-----LMMTVVTLDSDITPEAFRRVLEFLYTGVLDENEDDLKE 81

                          90
                  ....*....|
gi 1044873428 112 LLAAADQFNI 121
Cdd:cd18299    82 LKDAAELLEL 91

BTB_POZ_ZBTB35_ZNF131

cd18221

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-104

7.36e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349530 [Multi-domain] Cd Length: 113 Bit Score: 51.16 E-value: 7.36e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTsgwNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPI 104
Cdd:cd18221     9 LNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQ---DFTQEPLVEIEGVSNMAFRHLIEFTYTAKLMV 81

BTB_POZ_ZBTB6

cd18197

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-132

9.25e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349506 [Multi-domain] Cd Length: 116 Bit Score: 50.64 E-value: 9.25e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSgwnNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNV 109
Cdd:cd18197    17 NLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFLL---NQSKQVRITILQSAEVGRKLLLSCYTGALEVKKKEL 93

                          90       100
                  ....*....|....*....|...
gi 1044873428 110 EKLLAAADQFNIMGIVRGCCEFL 132
Cdd:cd18197    94 LKYLTAASYLQMVHIVEKCTEAL 116

Kelch_6

Kelch motif;

376-423

1.11e-07

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 48.49 E-value: 1.11e-07

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1044873428 376 RCYVSVTVLGNFIYAMGGF-DGYVRLNTAERYEPETNQWTLIAPMHEQR 423
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50

BTB_POZ_SPOP

cd18342

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

37-140

1.13e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349651 [Multi-domain] Cd Length: 125 Bit Score: 50.87 E-value: 1.13e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  37 KLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAA 116
Cdd:cd18342    21 RFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAA 100

                          90       100
                  ....*....|....*....|....
gi 1044873428 117 DQFNIMGIVRGCCEFLKSELCLDN 140
Cdd:cd18342   101 DKYALERLKVMCEDALCSNLSVEN 124

BTB_POZ_Rank-5

cd18303

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

37-142

1.38e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349612 [Multi-domain] Cd Length: 120 Bit Score: 50.40 E-value: 1.38e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  37 KLCDVVIKVNGFEFSAHKNILCSCSSYFRALftsgwNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVE--KLLA 114
Cdd:cd18303    17 LYSDITIKLADKSIPAHKFVLAARSEKWSNE-----NLASTNELDLSDISYEVVLALLRWLYTDELDLTLDDEFllELMK 91

                          90       100
                  ....*....|....*....|....*...
gi 1044873428 115 AADQFNIMGIVRGCCEFLKSELCLDNCI 142
Cdd:cd18303    92 AAKRFQLTDLVERCERALMSSVNVDNCI 119

BTB_POZ_BTBD6

cd18349

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

52-136

1.71e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349658 [Multi-domain] Cd Length: 109 Bit Score: 49.98 E-value: 1.71e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  52 AHKNILCSCSSYFRALFTSGWNNTEKKVYnIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEF 131
Cdd:cd18349    26 AHKYVLAVGSSVFYAMFYGDLAEVKSEIH-IPDVEPAAFLILLKYMYSDEIDLEADTVLATLYAAKKYIVPALAKACVNF 104


                  ....*
gi 1044873428 132 LKSEL 136
Cdd:cd18349   105 LETSL 109

BTB_POZ_ZBTB29-like

cd18216

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-133

1.73e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349525 [Multi-domain] Cd Length: 118 Bit Score: 50.22 E-value: 1.73e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTsgwnnTEKKVYNIP-GISPDMMKLIIEYAYT-RTVPITPD 107
Cdd:cd18216    12 NNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVL-----HDNLIHLDQdMVSPTVFQQILDFIYTgKLLDSLFE 86

                          90       100
                  ....*....|....*....|....*...
gi 1044873428 108 --NVEKLLAAADQFNIMGIVRGCCEFLK 133
Cdd:cd18216    87 epNLSEVLAAANYLQLPDLAALCRSKLK 114

PLN02193

nitrile-specifier protein

293-440

2.33e-07

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 53.42 E-value: 2.33e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 293 LFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEE--SPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTW-HQV 369
Cdd:PLN02193  231 LYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEgpTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWfHCS 310

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1044873428 370 APMHS--RRCYVSVTVLGNFIYAMGGFDGyVRLNTAERYEPETNQWTLIAPMHEQRSDAS--ATTLYGK-VYICGG 440
Cdd:PLN02193  311 TPGDSfsIRGGAGLEVVQGKVWVVYGFNG-CEVDDVHYYDPVQDKWTQVETFGVRPSERSvfASAAVGKhIVIFGG 385

BACK_KLHL9_13

cd18449

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...

136-232

2.58e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.

Pssm-ID: 350524 [Multi-domain] Cd Length: 95 Bit Score: 48.96 E-value: 2.58e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 136 LCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSaEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDP 215
Cdd:cd18449     1 VSLENCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTG-DFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHED 79

                          90
                  ....*....|....*..
gi 1044873428 216 qNRKQHISILLPKVRLA 232
Cdd:cd18449    80 -DRMQFAAKLMENIRFP 95

Kelch_6

Kelch motif;

328-376

3.42e-07

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 46.94 E-value: 3.42e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1044873428 328 PRAYHGAAYLKGYVYIIGGF-DSVDYFNSVKRFDPVKKTWHQVAPMHSRR 376
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50

BTB_POZ_ZBTB30_HIC2

cd18334

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-133

4.17e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349643 [Multi-domain] Cd Length: 120 Bit Score: 49.20 E-value: 4.17e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFtsgwnnTEKKVYNIPG--ISPDMMKLIIEYAYTRTVpITP 106
Cdd:cd18334    12 LNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLV------LHDNLINLDTdmVNPTVFRQILDFIYTGKL-LTS 84

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1044873428 107 D-----NVEKLLAAADQFNIMGIVRGCCEFLK 133
Cdd:cd18334    85 DqpgeqNFNALLTAASYLQLHDLAALCRKKLK 116

BTB_POZ_TDPOZ

cd18344

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

40-140

5.05e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349653 [Multi-domain] Cd Length: 128 Bit Score: 49.18 E-value: 5.05e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  40 DVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDN--VEKLLAAAD 117
Cdd:cd18344    25 DCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTGKAPHLHSHsmACDVLAAAD 104

                          90       100
                  ....*....|....*....|...
gi 1044873428 118 QFNIMGIVRGCCEFLKSELCLDN 140
Cdd:cd18344   105 KYGLEGLKVLCEDALCRNLSVEN 127

BTB_POZ_ZBTB47_ZNF651

cd18231

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-135

7.23e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349540 [Multi-domain] Cd Length: 115 Bit Score: 48.38 E-value: 7.23e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRL-EGKLCDV--VIKVNGFEFSAHKNILCSCSSYFRALFTSgwNNTEKKV-YNIPGISPDMMKLIIEYAYTRTVPI 104
Cdd:cd18231     4 LNEQRLfQPDLCDVdiVLVRQRSTFPAHKGVLAAYSQFFHSLFTQ--NKQLQRVeLSLEALTSQGLQQILNFIYTSKLLV 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1044873428 105 TPDNVEKLLAAADQFNIMGIVRGCCEFLKSE 135
Cdd:cd18231    82 NSCNVQDVLNAAAVLQMNDIAASCQELIDSR 112

BTB_POZ_ABTB2_BPOZ2

cd18350

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

38-142

7.27e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349659 [Multi-domain] Cd Length: 134 Bit Score: 48.69 E-value: 7.27e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  38 LCDVVIKVNGFEFSAHKNILCSCSSYFRALFT--SGWNNTEKKVYNIPGISPDMMKLIIEYAY---TRTVPITPDNVEKL 112
Cdd:cd18350    24 MSDVTFLVEGKLFYAHKVLLVTASNRFKSLLTnkSEQESQGSKTIEISDIKYHIFQMLMQYLYyggTESMEIPIADVLEL 103

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1044873428 113 LAAADQFNIMGIVRGcCEFLKSE-LCLDNCI 142
Cdd:cd18350   104 LSAASLFQLDALQRH-CEILCSQtINLENAV 133

BTB_POZ_ZBTB39

cd18224

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-128

8.58e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349533 [Multi-domain] Cd Length: 123 Bit Score: 48.29 E-value: 8.58e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTeKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNV 109
Cdd:cd18224    18 NKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTELDV-ARTYVVDFITPANFEKVLSFIYTSELFTDLINV 96

                          90
                  ....*....|....*....
gi 1044873428 110 EKLLAAADQFNIMGIVRGC 128
Cdd:cd18224    97 GVIYEVAEKLGMEDLLKAC 115

PLN02153

epithiospecifier protein

328-534

8.71e-07

epithiospecifier protein

Pssm-ID: 177814 [Multi-domain] Cd Length: 341 Bit Score: 51.14 E-value: 8.71e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 328 PRAYHGAAYLKGYVYIIGG----FDSVDyfNSVKRFDPVKKTWhQVAPMHSR----RCY-VSVTVLGNFIYAMGGFDGYV 398
Cdd:PLN02153   22 PRCSHGIAVVGDKLYSFGGelkpNEHID--KDLYVFDFNTHTW-SIAPANGDvpriSCLgVRMVAVGTKLYIFGGRDEKR 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 399 RLNTAERYEPETNQWTLIAPM-----------HEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIA-PM 466
Cdd:PLN02153   99 EFSDFYSYDTVKNEWTFLTKLdeeggpeartfHSMASDENHVYVFGGVSKGGLMKTPERFRTIEAYNIADGKWVQLPdPG 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 467 RS--RRSGIGVIAYGEHVYAVGGF------DGANRLRS--AEAYSPVANTWRTIPTMF---NPRSNFGIEVVDDLLFVVG 533
Cdd:PLN02153  179 ENfeKRGGAGFAVVQGKIWVVYGFatsilpGGKSDYESnaVQFFDPASGKWTEVETTGakpSARSVFAHAVVGKYIIIFG 258


                  .
gi 1044873428 534 G 534
Cdd:PLN02153  259 G 259

BTB_POZ_CP190-like

cd18311

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

30-122

9.25e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349620 [Multi-domain] Cd Length: 110 Bit Score: 47.58 E-value: 9.25e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRLEGKLCDVVIK-VNGFEFSAHKNILCSCSSYFRALftSGWNNTEKKVYNIPG-ISPDMMKLIIEYAYTRTVPITPD 107
Cdd:cd18311     6 QNLFNKTEYCDLTLQfRDNEQLKVHRLVLSACTDYFNVL--EQTCEIVDDTLIMPNeLQADAVVPVINFMYTGQLEFEEK 83

                          90
                  ....*....|....*
gi 1044873428 108 NVEKLLAAADQFNIM 122
Cdd:cd18311    84 SYGKLLRTAKELNMT 98

Kelch

Kelch domain;

293-339

9.59e-07

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 45.63 E-value: 9.59e-07

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1044873428  293 LFAIGGWSGGSPTNAIEAYDARADRWVNVTcEEESPRAYHGAAYLKG 339
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLP-SMPTPRSGHGVAVING 47

Kelch_3

Galactose oxidase, central domain;

338-384

1.10e-06

Galactose oxidase, central domain;

Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 45.74 E-value: 1.10e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1044873428 338 KGYVYIIGG--FDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVL 384
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49

BTB_POZ_BTBD1

cd18346

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

52-140

1.10e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349655 [Multi-domain] Cd Length: 133 Bit Score: 48.13 E-value: 1.10e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  52 AHKNILCSCSSYFRALFTSGWNNTEKKVyNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEF 131
Cdd:cd18346    46 AHRFVLAAGSAVFDAMFNGGMATTSAEI-ELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEF 124


                  ....*....
gi 1044873428 132 LKSELCLDN 140
Cdd:cd18346   125 LTKHLRADN 133

BTB_POZ_ZBTB3-like

cd18194

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

31-128

1.18e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349503 [Multi-domain] Cd Length: 128 Bit Score: 47.89 E-value: 1.18e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  31 ELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVE 110
Cdd:cd18194    16 EQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRLDKRDLVRLNSDIVTAPAFGLLLDFMYEGRLALRDLPVE 95

                          90
                  ....*....|....*...
gi 1044873428 111 KLLAAADQFNIMGIVRGC 128
Cdd:cd18194    96 DVLAAASYLHMYDIVKVC 113

BTB_POZ_ZBTB20_DPZF

cd18208

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-128

1.34e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349517 [Multi-domain] Cd Length: 117 Bit Score: 47.37 E-value: 1.34e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  27 EIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEkkvynIPG-ISPDMMKLIIEYAYTRTVPIT 105
Cdd:cd18208    14 ETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIE-----IPSvVSVQSVQKLIDFMYSGVLRVS 88

                          90       100
                  ....*....|....*....|...
gi 1044873428 106 PDNVEKLLAAADQFNIMGIVRGC 128
Cdd:cd18208    89 QSEALQILTAASILQIKTVIDEC 111

BACK_BTBD9

cd14822

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...

151-234

1.34e-06

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.

Pssm-ID: 350518 [Multi-domain] Cd Length: 101 Bit Score: 46.84 E-value: 1.34e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 151 YYCPELRQKAYMFILHNFEEmVKVSAEFLELSVTELKDIIEKDELNVKQEDaVFEAILKWISHDPqNRKQHISILLPKVR 230
Cdd:cd14822    16 YSLDDLCQTCCQFMDRNAQE-VLSSEGFLTLSKSALKELLSRDSFCAPEVD-IFNAVRRWCEHNP-DSKEDAKEILEAVR 92


                  ....
gi 1044873428 231 LALM 234
Cdd:cd14822    93 LPLM 96

BTB_POZ_RCBTB1_CLLD7

cd18353

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

40-137

1.54e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349662 [Multi-domain] Cd Length: 117 Bit Score: 47.25 E-value: 1.54e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  40 DVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQF 119
Cdd:cd18353    22 DLKFRVDGKYIHVHKAVLKIRCEHFRTMFQSHWNEDMKEVIEIDQFSYPVYRAFLEYLYTDSVDLPPEDAIGLLDLATSY 101

                          90
                  ....*....|....*...
gi 1044873428 120 nimgivrgcCEFLKSELC 137
Cdd:cd18353   102 ---------CENRLKKLC 110

BTB_POZ_ZBTB43

cd18227

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-133

2.43e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349536 [Multi-domain] Cd Length: 121 Bit Score: 46.86 E-value: 2.43e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYF--RALFtsgwNNTEKKVynIPGI-SPDMMKLIIEYAYTRTVPIT 105
Cdd:cd18227    16 LNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFcdQVLL----KNSRRIV--LPDVmNPRVFENILLSCYTGRLVLP 89

                          90       100
                  ....*....|....*....|....*...
gi 1044873428 106 PDNVEKLLAAADQFNIMGIVRGCCEFLK 133
Cdd:cd18227    90 APEIVSYLTAASFLQMWHVVDKCTELLE 117

Kelch_6

Kelch motif;

470-517

3.30e-06

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 44.25 E-value: 3.30e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1044873428 470 RSGIGVIAYGEHVYAVGGF-DGANRLRSAEAYSPVANTWRTIPTMFNPR 517
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50

BTB1_POZ_BTBD7

cd18283

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

40-119

3.45e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349592 [Multi-domain] Cd Length: 92 Bit Score: 45.40 E-value: 3.45e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  40 DVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIP--GISPDMMKLIIEYAYT---RTVPITPDNVEKLLA 114
Cdd:cd18283     4 DVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPtaGIDVPMFSALLRYLYTgefGSEDSRSQNLDVLIQ 83


                  ....*
gi 1044873428 115 AADQF 119
Cdd:cd18283    84 LSEEF 88

BTB_POZ_BTBD2

cd18347

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

52-140

3.56e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349656 [Multi-domain] Cd Length: 127 Bit Score: 46.61 E-value: 3.56e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  52 AHKNILCSCSSYFRALFTSGWNNTEKKVyNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEF 131
Cdd:cd18347    40 AHRFVLAVGSAVFDAMFNGGMATTSTEI-ELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEF 118


                  ....*....
gi 1044873428 132 LKSELCLDN 140
Cdd:cd18347   119 LKKNLRADN 127

PHA02713

hypothetical protein; Provisional

437-572

3.57e-06

hypothetical protein; Provisional

Pssm-ID: 165086 [Multi-domain] Cd Length: 557 Bit Score: 50.01 E-value: 3.57e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 437 ICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGAN-RLRSAEAYSPVANTWRTIPTMFN 515
Cdd:PHA02713  261 VCHDTKYNVCNPCILVYNINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYNFNNpSLNKVYKINIENKIHVELPPMIK 340

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1044873428 516 PRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVV 572
Cdd:PHA02713  341 NRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVL 397

BTB_POZ_ZBTB41

cd18226

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

30-126

3.81e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349535 [Multi-domain] Cd Length: 114 Bit Score: 45.95 E-value: 3.81e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  30 NELRL-EGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSgwnNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDN 108
Cdd:cd18226    13 NDDRQkQSSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLSK---NPNTDAVTLDHVSYSVFQHLLEFLYTSEFFVYENE 89

                          90
                  ....*....|....*...
gi 1044873428 109 VEKLLAAADQFNIMGIVR 126
Cdd:cd18226    90 IPLVLEAAKFLDIIDAVK 107

BACK_BTBD17

cd18493

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...

155-211

4.08e-06

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.

Pssm-ID: 350568 Cd Length: 74 Bit Score: 44.88 E-value: 4.08e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1044873428 155 ELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWI 211
Cdd:cd18493    19 ELAEACLEFIAWNFEKVLK-SPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74

BTB_POZ_BTBD11

cd18351

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

37-142

6.69e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349660 [Multi-domain] Cd Length: 131 Bit Score: 45.74 E-value: 6.69e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  37 KLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNtEKKVYNIPGISPDMMKLIIEYAY---TRTVPITPDNVEKLL 113
Cdd:cd18351    23 EMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNKPSA-ENTCIEISYVKYHIFQLVMQYLYcggTESLLIKNNEIMELL 101

                          90       100
                  ....*....|....*....|....*....
gi 1044873428 114 AAADQFNIMGIVRGCCEFLKSELCLDNCI 142
Cdd:cd18351   102 SAAKFFQLEALQRHCEIICAKSINTENCV 130

BTB1_POZ_KLHL33

cd18262

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

31-117

1.95e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349571 [Multi-domain] Cd Length: 101 Bit Score: 43.74 E-value: 1.95e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  31 ELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRA--LFTSGWnntekKVYNIPGISPDMMKLIIEYAYTRTVPITPDN 108
Cdd:cd18262    11 RLREQRLLLDETVSVGGRSYGVHSVILAAVSSLFRErlLGSNGP-----LPPLSLEVTPVGWEAVLTFAYTGVLGRNPAT 85


                  ....*....
gi 1044873428 109 VEKLLAAAD 117
Cdd:cd18262    86 VGDILVAAE 94

BACK_NS1BP_IVNS1ABP

cd18502

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...

136-211

2.06e-05

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.

Pssm-ID: 350577 Cd Length: 99 Bit Score: 43.38 E-value: 2.06e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1044873428 136 LCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELkDII--EKDELNVKQEDAVFEAILKWI 211
Cdd:cd18502     1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAE-SKEFLKLPRLQI-EVIleSNQELESINERKLCQLVLEWV 76

BACK_KLHL31_KBTBD1

cd18470

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...

138-231

2.98e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).

Pssm-ID: 350545 Cd Length: 98 Bit Score: 42.94 E-value: 2.98e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 138 LDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDpQN 217
Cdd:cd18470     3 VENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSE-TDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-QK 80

                          90
                  ....*....|....
gi 1044873428 218 RKQHISILLPKVRL 231
Cdd:cd18470    81 RVKYAADLLSNIRF 94

Kelch_4

pfam13418

Galactose oxidase, central domain;

328-372

3.19e-05

Galactose oxidase, central domain;

Pssm-ID: 433191 [Multi-domain] Cd Length: 49 Bit Score: 41.44 E-value: 3.19e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1044873428 328 PRAYHGAAYL-KGYVYIIGGF-DSVDYFNSVKRFDPVKKTWHQVAPM 372
Cdd:pfam13418   1 PRAYHTSTSIpDDTIYLFGGEgEDGTLLSDLWVFDLSTNEWTRLGSL 47

BTB_POZ_ZBTB45

cd18229

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

27-132

4.90e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349538 [Multi-domain] Cd Length: 112 Bit Score: 42.92 E-value: 4.90e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  27 EIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKvyniPGISPDMMKLIIEYAYTRTVPITP 106
Cdd:cd18229     7 ETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLGHSEIEVP----PVVPAQTVRQLVEFMYSGSLVVAQ 82

                          90       100
                  ....*....|....*....|....*.
gi 1044873428 107 DNVEKLLAAADQFNIMGIVRGCCEFL 132
Cdd:cd18229    83 SEALQILTAASILQIKTVIDECTQII 108

BACK_KLHL14

cd18453

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...

165-247

7.10e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.

Pssm-ID: 350528 Cd Length: 102 Bit Score: 42.31 E-value: 7.10e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 165 LHNFEEMVKVSAEF-----LELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYF 239
Cdd:cd18453    15 LHGLEETKKLANKYlvedvLLLNFEEMRAMLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPEL 94


                  ....*...
gi 1044873428 240 MNNVKMND 247
Cdd:cd18453    95 VERVQSVD 102

PRK14131

N-acetylneuraminate epimerase;

334-413

9.28e-05

N-acetylneuraminate epimerase;

Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 45.01 E-value: 9.28e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 334 AAYLKGYVYIIGGFD------SVDYFNSVKRFDPVKKTWHQVaPMHSRRCYV---SVTVLGNFIYAMGG-----FDGYVR 399
Cdd:PRK14131   80 AAFIDGKLYVFGGIGktnsegSPQVFDDVYKYDPKTNSWQKL-DTRSPVGLAghvAVSLHNGKAYITGGvnkniFDGYFE 158

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1044873428 400 -LNTAER----------------------------YEPETNQW 413
Cdd:PRK14131  159 dLAAAGKdktpkdkindayfdkkpedyffnkevlsYDPSTNQW 201

BTB2_POZ_RHOBTB1

cd18358

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

35-119

1.23e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349667 [Multi-domain] Cd Length: 126 Bit Score: 42.26 E-value: 1.23e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  35 EGKLCDVVIKVNGFEFSAHKNIL-CSCSsYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPD-NVEKL 112
Cdd:cd18358    17 KGTFSDVTFKLDDGTINAHKPLLiCSCE-WMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQLSPTADlDPLEL 95


                  ....*..
gi 1044873428 113 LAAADQF 119
Cdd:cd18358    96 IALANRF 102

mutarot_permut

TIGR03548

cyclically-permuted mutarotase family protein; Members of this protein family show essentially ...

379-536

1.48e-04

Pssm-ID: 274642 [Multi-domain] Cd Length: 331 Bit Score: 44.40 E-value: 1.48e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 379 VSVTVlGNFIYAMGGFDGYVRLNTAERYEPETNQWTLI----APMHEQRSDASATTLYGKVYICGG-FNGNEclfTAEVY 453
Cdd:TIGR03548  68 ASVST-PYGIYYVGGSPSSESFSDVLLLSLDDTKEALIietlPSLPVAFDNGSATYKDGKIYVGGGnANGKP---SNKFY 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 454 ----NTESNQWTVIA--PMRSRRSGIGVIAYGEhVYAVGGFDGAnrlRSAE------AYSPVANTWRTIPTMF----NPR 517
Cdd:TIGR03548 144 cldlSNDTSGWEELPefPGEARVQPVCQALHGK-LYVFGGFQLG---GDAIiytdgyAYSPKTNTWQTVADPVlsdgEPI 219

                         170       180
                  ....*....|....*....|..
gi 1044873428 518 SNFG---IEVVDDLLFVVGGFN 536
Cdd:TIGR03548 220 TLLGgnsVKLGDSLMLVIGGVN 241

Kelch_3

Galactose oxidase, central domain;

479-522

1.49e-04

Galactose oxidase, central domain;

Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 39.58 E-value: 1.49e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1044873428 479 GEHVYAVGG--FDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGI 522
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSA 46

PRK14131

N-acetylneuraminate epimerase;

387-490

1.97e-04

N-acetylneuraminate epimerase;

Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 43.85 E-value: 1.97e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 387 FIYAMGGFDG---YVRLNTAER--YEPETN----QWTLIA--PMHEqRSDASATTLYGKVYICGGF-----NGNECLF-T 449
Cdd:PRK14131   29 FKNGTGAIDNntvYVGLGSAGTswYKLDLNapskGWTKIAafPGGP-REQAVAAFIDGKLYVFGGIgktnsEGSPQVFdD 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1044873428 450 AEVYNTESNQWTVIaPMRSRRS---GIGVIAYGEHVYAVGG-----FDG 490
Cdd:PRK14131  108 VYKYDPKTNSWQKL-DTRSPVGlagHVAVSLHNGKAYITGGvnkniFDG 155

BTB_POZ_ZBTB12

cd18203

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

11-68

2.17e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349512 [Multi-domain] Cd Length: 122 Bit Score: 41.40 E-value: 2.17e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1044873428  11 RFHQPHMErkmsAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALF 68
Cdd:cd18203     2 RFQLPGHE----AATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQF 55

Kelch_2

pfam07646

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

423-466

2.29e-04

Pssm-ID: 462220 [Multi-domain] Cd Length: 47 Bit Score: 39.24 E-value: 2.29e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1044873428 423 RSDASATTLYGKVYICGGF--NGNECLFTAEVYNTESNQWTVIAPM 466
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSdgLGDLSSSDVLVYDPETNVWTEVPRL 47

BACK_BTBD19

cd18494

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); ...

155-210

2.46e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.

Pssm-ID: 350569 Cd Length: 73 Bit Score: 39.60 E-value: 2.46e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1044873428 155 ELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKQEDaVFEAILKW 210
Cdd:cd18494    19 ELKERCLAFIEEHTEEVFK-TKGFHELSDEALSVILRSDKLRIDELD-ILKAVREW 72

BTB_POZ_BTBD3

cd18348

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

52-140

3.23e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349657 [Multi-domain] Cd Length: 131 Bit Score: 41.16 E-value: 3.23e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  52 AHKNILCSCSSYFRALFTsGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEF 131
Cdd:cd18348    39 GHKYVLAVGSSVFHAMFY-GELAEDKDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNF 117


                  ....*....
gi 1044873428 132 LKSELCLDN 140
Cdd:cd18348   118 LETSLSAKN 126

BACK_KLHL32_BKLHD5

cd18471

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...

140-234

4.74e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.

Pssm-ID: 350546 [Multi-domain] Cd Length: 98 Bit Score: 39.89 E-value: 4.74e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 140 NCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSA-EFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDpqNR 218
Cdd:cd18471     5 NYLDLYKLADLFNLTLLEEAVVDFLVKHLSELLKSHPeEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHN--CR 82

                          90
                  ....*....|....*.
gi 1044873428 219 KQHISILLPKVRLALM 234
Cdd:cd18471    83 YQYMDELLQYVRFGLM 98

BACK_BTBD3_like

cd18488

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and ...

154-220

4.90e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This subfamily includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.

Pssm-ID: 350563 Cd Length: 95 Bit Score: 39.66 E-value: 4.90e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1044873428 154 PELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKqEDAVFEAILKW---------ISHDPQNRKQ 220
Cdd:cd18488    19 PELMQRCWEVIDAQAELALK-SEGFTEIDYKTLESILRRETLNAK-ESVVFEAALRWaeaecqrrgLEPTPENKRK 92

Kelch_2

pfam07646

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

328-372

5.29e-04

Pssm-ID: 462220 [Multi-domain] Cd Length: 47 Bit Score: 38.09 E-value: 5.29e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1044873428 328 PRAYHGAAYLKGYVYIIGGFDS--VDYFNSVKRFDPVKKTWHQVAPM 372
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGlgDLSSSDVLVYDPETNVWTEVPRL 47

Kelch_3

Galactose oxidase, central domain;

433-478

5.85e-04

Galactose oxidase, central domain;

Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 38.04 E-value: 5.85e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1044873428 433 GKVYICGGFN--GNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAY 478
Cdd:pfam13415   2 DKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49

Kelch_3

Galactose oxidase, central domain;

385-429

6.52e-04

Galactose oxidase, central domain;

Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 37.65 E-value: 6.52e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1044873428 385 GNFIYAMGG--FDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASAT 429
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSAT 47

BTB_POZ_ZBTB2

cd18193

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

29-99

7.51e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349502 [Multi-domain] Cd Length: 115 Bit Score: 39.59 E-value: 7.51e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1044873428  29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTsgwNNTEKKVYNIPG-ISPDMMKLIIEYAYT 99
Cdd:cd18193    12 LNAQREFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLFV---HQTSECVRLKPTdIQPDIFSYLLHLMYT 80

BTB_POZ_ETO1-like

cd18190

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

40-119

9.37e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349499 [Multi-domain] Cd Length: 83 Bit Score: 38.27 E-value: 9.37e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  40 DVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIP--GISPDMMKLIIEYAYTRTVPITP-DNVEKLLAAA 116
Cdd:cd18190     1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEenGISIEAMRAVIDFSVTGRLDLFSvENVHEVLELA 80


                  ...
gi 1044873428 117 DQF 119
Cdd:cd18190    81 SKF 83

BTB2_POZ_RHOBTB2

cd18359

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

35-107

1.31e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349668 [Multi-domain] Cd Length: 124 Bit Score: 39.22 E-value: 1.31e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1044873428  35 EGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPD 107
Cdd:cd18359    17 KGTFSDVTFMLDDGTISAHKPLLISSCDWMAAMFGGPFVESSTTEVVFPYTSRSSMRAVLEYLYTGQFSSSPD 89

Kelch_6

Kelch motif;

423-470

1.38e-03

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 36.93 E-value: 1.38e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1044873428 423 RSDASATTLYGKVYICGGFNGNECLF-TAEVYNTESNQWTVIAPMRSRR 470
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNASPALnKLEVYNPLTKSWEELPPLPTPR 50

BACK_BTBD6

cd18525

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6); ...

154-210

1.39e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also called lens BTB domain protein, is a BTB-domain-containing Kelch-like protein that is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.

Pssm-ID: 350600 Cd Length: 95 Bit Score: 38.14 E-value: 1.39e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1044873428 154 PELRQKAYMFILHNFEEMVKvSAEFLELSVTELKDIIEKDELNVKqEDAVFEAILKW 210
Cdd:cd18525    19 PELTQRCWEVIDAQAELALK-SEGFCEIDQQTLEIILTRETLNTK-EVVVFEAVLNW 73

BTB_POZ_ZBTB42

cd18956

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

33-128

1.75e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349737 [Multi-domain] Cd Length: 129 Bit Score: 39.03 E-value: 1.75e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428  33 RLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALF---TSGWNNTEKKVYNIpgISPDMMKLIIEYAYTRTVPITPDNV 109
Cdd:cd18956    18 RELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYrdrPAGGRDTVRLNGDI--VTAPAFGRLLDFMYEGRLDLRSLPV 95

                          90
                  ....*....|....*....
gi 1044873428 110 EKLLAAADQFNIMGIVRGC 128
Cdd:cd18956    96 EDVLAAASYLHMYDIVKVC 114

Kelch_4

pfam13418

Galactose oxidase, central domain;

375-419

2.84e-03

Galactose oxidase, central domain;

Pssm-ID: 433191 [Multi-domain] Cd Length: 49 Bit Score: 36.05 E-value: 2.84e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1044873428 375 RRCYVSVTVLGNFIYAMGGFDG-YVRLNTAERYEPETNQWTLIAPM 419
Cdd:pfam13418   2 RAYHTSTSIPDDTIYLFGGEGEdGTLLSDLWVFDLSTNEWTRLGSL 47

BACK_KLHL36

cd18475

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...

149-234

3.56e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Pssm-ID: 350550 Cd Length: 100 Bit Score: 37.13 E-value: 3.56e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044873428 149 DYYYCPEL-------RQKAYM--FILHNFEEMvKVSAEFLE-LSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQnR 218
Cdd:cd18475     5 NYLYLQELasiysleRLDSFIdsFILQNFGTL-SFTPDFLQnVSMQKLCQYLSSNQVQHECEHDLLQAALQWLTQSPE-R 82

                          90
                  ....*....|....*.
gi 1044873428 219 KQHISILLPKVRLALM 234
Cdd:cd18475    83 ENEAYQVLSNIHFPLI 98

Kelch_1