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Conserved domains on  [gi|1044556434|ref|XP_017414365|]
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uncharacterized protein LOC108325798 isoform X1 [Vigna angularis]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 10446569)

SANT/Myb domain-containing protein binds DNA and may function as a transcription factor

CATH:  1.10.10.60
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  1631139|8882580

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 994-1032 2.35e-08

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 51.35  E-value: 2.35e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1044556434  994 WTDDEKAAFLQAVSSFGKDFAKIARCVGTRSQEQCKVFF 1032
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRW 42
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 777-820 8.06e-08

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 49.81  E-value: 8.06e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1044556434  777 NPWTPQEREIFLEKFAVFGKNFRKIASFLDHKTTADCVEFYYKN 820
Cdd:pfam00249    2 GPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNY 45
RSC8 super family cl34960
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / ...
 994-1086 5.71e-04

RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription];


The actual alignment was detected with superfamily member COG5259:

Pssm-ID: 227584 [Multi-domain]  Cd Length: 531  Bit Score: 44.49  E-value: 5.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044556434  994 WTDDEKAAFLQAVSSFGKDFAKIARCVGTRSQEQCKVFFskgrkclgldLMRPIPEN-----VGSPVNDdaNGGES-DTD 1067
Cdd:COG5259    282 WSRQELLLLLEGIEMYGDDWDKVARHVGTKTKEQCILHF----------LQLPIEDNylskgDGKGDNS--KGRLPfDGS 349

                           90       100
                   ....*....|....*....|....*..
gi 1044556434 1068 DACVVETGSM--------VETEKSGTK 1086
Cdd:COG5259    350 ENPVLSTISFlagivnprVQSEKQRAI 376
 
Name Accession Description Interval E-value
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 994-1032 2.35e-08

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 51.35  E-value: 2.35e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1044556434  994 WTDDEKAAFLQAVSSFGKDFAKIARCVGTRSQEQCKVFF 1032
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRW 42
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 994-1032 7.06e-08

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 50.27  E-value: 7.06e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1044556434  994 WTDDEKAAFLQAVSSFG-KDFAKIARCVGTRSQEQCKVFF 1032
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERW 41
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 777-820 8.06e-08

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 49.81  E-value: 8.06e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1044556434  777 NPWTPQEREIFLEKFAVFGKNFRKIASFLDHKTTADCVEFYYKN 820
Cdd:pfam00249    2 GPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNY 45
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 779-818 9.08e-08

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 49.92  E-value: 9.08e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1044556434  779 WTPQEREIFLEKFAVFGKNFRKI-ASFLDHKTTADCVEFYY 818
Cdd:cd11661      2 WSESEAKLFEEGLRKYGKDFHDIrQDFLPWKSVGELVEFYY 42
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
777-823 2.54e-07

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 48.76  E-value: 2.54e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 1044556434   777 NPWTPQEREIFLEKFAVFG-KNFRKIASFLDHKTTADCVEFYYKNHKS 823
Cdd:smart00717    2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
992-1032 2.85e-07

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 48.37  E-value: 2.85e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1044556434   992 TDWTDDEKAAFLQAVSSFG-KDFAKIARCVGTRSQEQCKVFF 1032
Cdd:smart00717    2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERW 43
RSC8 COG5259
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / ...
 994-1086 5.71e-04

RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227584 [Multi-domain]  Cd Length: 531  Bit Score: 44.49  E-value: 5.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044556434  994 WTDDEKAAFLQAVSSFGKDFAKIARCVGTRSQEQCKVFFskgrkclgldLMRPIPEN-----VGSPVNDdaNGGES-DTD 1067
Cdd:COG5259    282 WSRQELLLLLEGIEMYGDDWDKVARHVGTKTKEQCILHF----------LQLPIEDNylskgDGKGDNS--KGRLPfDGS 349

                           90       100
                   ....*....|....*....|....*..
gi 1044556434 1068 DACVVETGSM--------VETEKSGTK 1086
Cdd:COG5259    350 ENPVLSTISFlagivnprVQSEKQRAI 376
 
Name Accession Description Interval E-value
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 994-1032 2.35e-08

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 51.35  E-value: 2.35e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1044556434  994 WTDDEKAAFLQAVSSFGKDFAKIARCVGTRSQEQCKVFF 1032
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRW 42
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 994-1032 7.06e-08

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 50.27  E-value: 7.06e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1044556434  994 WTDDEKAAFLQAVSSFG-KDFAKIARCVGTRSQEQCKVFF 1032
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERW 41
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 777-820 8.06e-08

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 49.81  E-value: 8.06e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1044556434  777 NPWTPQEREIFLEKFAVFGKNFRKIASFLDHKTTADCVEFYYKN 820
Cdd:pfam00249    2 GPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNY 45
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 779-818 9.08e-08

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 49.92  E-value: 9.08e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1044556434  779 WTPQEREIFLEKFAVFGKNFRKI-ASFLDHKTTADCVEFYY 818
Cdd:cd11661      2 WSESEAKLFEEGLRKYGKDFHDIrQDFLPWKSVGELVEFYY 42
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
777-823 2.54e-07

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 48.76  E-value: 2.54e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 1044556434   777 NPWTPQEREIFLEKFAVFG-KNFRKIASFLDHKTTADCVEFYYKNHKS 823
Cdd:smart00717    2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
992-1032 2.85e-07

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 48.37  E-value: 2.85e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1044556434   992 TDWTDDEKAAFLQAVSSFG-KDFAKIARCVGTRSQEQCKVFF 1032
Cdd:smart00717    2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERW 43
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 778-820 4.91e-07

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 47.57  E-value: 4.91e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1044556434  778 PWTPQEREIFLEKFAVFG-KNFRKIASFLDHKTTADCVEFYYKN 820
Cdd:cd00167      1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNL 44
RSC8 COG5259
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / ...
 994-1086 5.71e-04

RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227584 [Multi-domain]  Cd Length: 531  Bit Score: 44.49  E-value: 5.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1044556434  994 WTDDEKAAFLQAVSSFGKDFAKIARCVGTRSQEQCKVFFskgrkclgldLMRPIPEN-----VGSPVNDdaNGGES-DTD 1067
Cdd:COG5259    282 WSRQELLLLLEGIEMYGDDWDKVARHVGTKTKEQCILHF----------LQLPIEDNylskgDGKGDNS--KGRLPfDGS 349

                           90       100
                   ....*....|....*....|....*..
gi 1044556434 1068 DACVVETGSM--------VETEKSGTK 1086
Cdd:COG5259    350 ENPVLSTISFlagivnprVQSEKQRAI 376
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 779-825 7.64e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 39.22  E-value: 7.64e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1044556434  779 WTPQEREIFLEKFAVFGKNFRKIASFLDHKTTADCVEFYYKNHKSDC 825
Cdd:pfam13921    1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRKLNPKI 47
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 994-1029 1.43e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 38.45  E-value: 1.43e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1044556434  994 WTDDEKAAFLQAVSSFGKDFAKIARCVGTRSQEQCK 1029
Cdd:pfam13921    1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCF 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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