NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|10434458|dbj|BAB14265|]
View 

unnamed protein product [Homo sapiens]

Protein Classification

mitochondrial import receptor subunit TOM40 family protein( domain architecture ID 10163980)

mitochondrial import receptor subunit TOM40 family protein is a porin similar to translocase of outer mitochondrial membrane 40 (Tom40) which forms channels in the mitochondrial outer membrane and functions as a transport channel for unfolded protein chains

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Porin3_Tom40 cd07305
Translocase of outer mitochondrial membrane 40 (Tom40); Tom40 forms a channel in the ...
 3-190 1.48e-80

Translocase of outer mitochondrial membrane 40 (Tom40); Tom40 forms a channel in the mitochondrial outer membrane with a pore about 1.5 to 2.5 nanometers wide. It functions as a transport channel for unfolded protein chains and forms a complex with Tom5, Tom6, Tom7, and Tom22. The primary receptors Tom20 and Tom70 recruit the unfolded precursor protein from the mitochondrial-import stimulating factor (MSF) or cytosolic Hsc70. The precursor passes through the Tom40 channel and through another channel in the inner membrane, formed by Tim23, to be finally translocated into the mitochondrial matrix. The process depends on a proton motive force across the inner membrane and requires a contact site where the outer and inner membranes come close. Tom40 is also involved in inserting outer membrane proteins into the membrane, most likely not via a lateral opening in the pore, but by transfering precursor proteins to an outer membrane sorting and assembly machinery.


:

Pssm-ID: 132766 [Multi-domain]  Cd Length: 279  Bit Score: 240.57  E-value: 1.48e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10434458   3 CTVYAKTQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESVIMVAHFLQSLTHRLVLGGELVYHRRPGEEGAILTLAGK 82
Cdd:cd07305  94 SKLQAQLQDSKFNMSQLELDYRGDDFTASLKLANPDILNETGIYVASYLQSVTPKLALGGELVYQRVPGNGISVLSYAAR 173

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10434458  83 YSAVHWVATLNVGS-GGAHASYYHRANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQAnmVFRGLVDSNWCVGAVLEKKM 161
Cdd:cd07305 174 YTAGNWIASGQLGAqGGLHLSYYRKLSDKLQLGVELELNLRTRESTATLGYQYDFRQS--RFRGSIDSNGKVSAVLEKRL 251

                       170       180
                ....*....|....*....|....*....
gi 10434458 162 PPlPVTLALGAFLNHWRNRFHCGFSITVG 190
Cdd:cd07305 252 PL-PLSLLLSGELNHVKNDYKFGFGLTIG 279
 
Name Accession Description Interval E-value
Porin3_Tom40 cd07305
Translocase of outer mitochondrial membrane 40 (Tom40); Tom40 forms a channel in the ...
 3-190 1.48e-80

Translocase of outer mitochondrial membrane 40 (Tom40); Tom40 forms a channel in the mitochondrial outer membrane with a pore about 1.5 to 2.5 nanometers wide. It functions as a transport channel for unfolded protein chains and forms a complex with Tom5, Tom6, Tom7, and Tom22. The primary receptors Tom20 and Tom70 recruit the unfolded precursor protein from the mitochondrial-import stimulating factor (MSF) or cytosolic Hsc70. The precursor passes through the Tom40 channel and through another channel in the inner membrane, formed by Tim23, to be finally translocated into the mitochondrial matrix. The process depends on a proton motive force across the inner membrane and requires a contact site where the outer and inner membranes come close. Tom40 is also involved in inserting outer membrane proteins into the membrane, most likely not via a lateral opening in the pore, but by transfering precursor proteins to an outer membrane sorting and assembly machinery.


Pssm-ID: 132766 [Multi-domain]  Cd Length: 279  Bit Score: 240.57  E-value: 1.48e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10434458   3 CTVYAKTQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESVIMVAHFLQSLTHRLVLGGELVYHRRPGEEGAILTLAGK 82
Cdd:cd07305  94 SKLQAQLQDSKFNMSQLELDYRGDDFTASLKLANPDILNETGIYVASYLQSVTPKLALGGELVYQRVPGNGISVLSYAAR 173

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10434458  83 YSAVHWVATLNVGS-GGAHASYYHRANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQAnmVFRGLVDSNWCVGAVLEKKM 161
Cdd:cd07305 174 YTAGNWIASGQLGAqGGLHLSYYRKLSDKLQLGVELELNLRTRESTATLGYQYDFRQS--RFRGSIDSNGKVSAVLEKRL 251

                       170       180
                ....*....|....*....|....*....
gi 10434458 162 PPlPVTLALGAFLNHWRNRFHCGFSITVG 190
Cdd:cd07305 252 PL-PLSLLLSGELNHVKNDYKFGFGLTIG 279
Porin_3 pfam01459
Eukaryotic porin;
7-179 2.48e-41

Eukaryotic porin;


Pssm-ID: 460220 [Multi-domain]  Cd Length: 269  Bit Score: 140.04  E-value: 2.48e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10434458     7 AKTQQAKFlTWQFDGEYRGDDYTATLTLGNpdliGESVIMVAHFLQSLTHrLVLGGELVYHRRPGEEGAIlTLAGKYSAV 86
Cdd:pfam01459  97 TQFVPGKK-SGKLELDYKGDDFTASLKVGL----LAGPVVVGSYLQGVTG-LALGAEASYDTASGKLTKY-NAALGYTAR 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10434458    87 HWVATLNVGS--GGAHASYYHRANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQANMVfRGLVDSNWCVGAVLEKKMPPl 164
Cdd:pfam01459 170 DYIASLTLVNngGVLTASYYHKVSEKLEVGAELTLNFSSNENTVTIGYKYDLDKSTTV-KAKVNSNGKVGLLYEQKLRP- 247

                         170
                  ....*....|....*
gi 10434458   165 PVTLALGAFLNHWRN 179
Cdd:pfam01459 248 GVTLTLSAEVDHKKL 262
3a0801s07tom40 TIGR00989
mitochondrial import receptor subunit Tom40; The mitochondrial protein translocase (MPT) ...
 18-66 2.98e-04

mitochondrial import receptor subunit Tom40; The mitochondrial protein translocase (MPT) family, which brings nuclearly encoded preproteins into mitochondria, is very complex with 19 currently identified protein constituents.These proteins include several chaperone proteins, four proteins of the outer membrane translocase (Tom) import receptor, five proteins of the Tom channel complex, five proteins of the inner membrane translocase (Tim) and three "motor" proteins. This family is specific for the Tom40 proteins. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130062  Cd Length: 161  Bit Score: 39.49  E-value: 2.98e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 10434458    18 QFDGEYRGDDYTATLTLGNPDLI--GESVIMVAHFLQSLTHRLVLGGELVY 66
Cdd:TIGR00989 110 QFEHDHLGDDFSASLKAINPSFLekGLTGIFVGSYLQSVTPRLGLGLEALW 160
 
Name Accession Description Interval E-value
Porin3_Tom40 cd07305
Translocase of outer mitochondrial membrane 40 (Tom40); Tom40 forms a channel in the ...
 3-190 1.48e-80

Translocase of outer mitochondrial membrane 40 (Tom40); Tom40 forms a channel in the mitochondrial outer membrane with a pore about 1.5 to 2.5 nanometers wide. It functions as a transport channel for unfolded protein chains and forms a complex with Tom5, Tom6, Tom7, and Tom22. The primary receptors Tom20 and Tom70 recruit the unfolded precursor protein from the mitochondrial-import stimulating factor (MSF) or cytosolic Hsc70. The precursor passes through the Tom40 channel and through another channel in the inner membrane, formed by Tim23, to be finally translocated into the mitochondrial matrix. The process depends on a proton motive force across the inner membrane and requires a contact site where the outer and inner membranes come close. Tom40 is also involved in inserting outer membrane proteins into the membrane, most likely not via a lateral opening in the pore, but by transfering precursor proteins to an outer membrane sorting and assembly machinery.


Pssm-ID: 132766 [Multi-domain]  Cd Length: 279  Bit Score: 240.57  E-value: 1.48e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10434458   3 CTVYAKTQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESVIMVAHFLQSLTHRLVLGGELVYHRRPGEEGAILTLAGK 82
Cdd:cd07305  94 SKLQAQLQDSKFNMSQLELDYRGDDFTASLKLANPDILNETGIYVASYLQSVTPKLALGGELVYQRVPGNGISVLSYAAR 173

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10434458  83 YSAVHWVATLNVGS-GGAHASYYHRANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQAnmVFRGLVDSNWCVGAVLEKKM 161
Cdd:cd07305 174 YTAGNWIASGQLGAqGGLHLSYYRKLSDKLQLGVELELNLRTRESTATLGYQYDFRQS--RFRGSIDSNGKVSAVLEKRL 251

                       170       180
                ....*....|....*....|....*....
gi 10434458 162 PPlPVTLALGAFLNHWRNRFHCGFSITVG 190
Cdd:cd07305 252 PL-PLSLLLSGELNHVKNDYKFGFGLTIG 279
Porin3 cd07303
Eukaryotic porin family that forms channels in the mitochondrial outer membrane; The porin ...
 10-190 1.30e-45

Eukaryotic porin family that forms channels in the mitochondrial outer membrane; The porin family 3 contains two sub-families that play vital roles in the mitochondrial outer membrane, a translocase for unfolded pre-proteins (Tom40) and the voltage-dependent anion channel (VDAC) that regulates the flux of mostly anionic metabolites through the outer mitochondrial membrane.


Pssm-ID: 132765 [Multi-domain]  Cd Length: 274  Bit Score: 151.27  E-value: 1.30e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10434458  10 QQAKFLTWQFDGEYRGDDYTATLTLGNpdligeSVIMVAHFLQSLTHRLVLGGELVYHR--RPGEEGAILTLAGKYSavH 87
Cdd:cd07303 101 PNTGKKNAKIKTGYKRINLGCDVDFDI------AGPLIRGALVLGYEGWLAGYQMVFETvsRVTQSNFAVGYKTDYN--E 172

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10434458  88 WVATLNVGSG-GAHASYYHRANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQaNMVFRGLVDSNWCVGAVLEKKMPPlPV 166
Cdd:cd07303 173 FQAHTNVNDGtEFGGSIYHKVNDKLEVGVNLAATAGNSNTRFGIAAKYQVDP-DACFSASVNNSSLVGLGYTQTLKP-GI 250

                       170       180
                ....*....|....*....|....
gi 10434458 167 TLALGAFLNHWRNRFHCGFSITVG 190
Cdd:cd07303 251 KLTLSALLDHKAGGHKLGLGLEFQ 274
Porin_3 pfam01459
Eukaryotic porin;
7-179 2.48e-41

Eukaryotic porin;


Pssm-ID: 460220 [Multi-domain]  Cd Length: 269  Bit Score: 140.04  E-value: 2.48e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10434458     7 AKTQQAKFlTWQFDGEYRGDDYTATLTLGNpdliGESVIMVAHFLQSLTHrLVLGGELVYHRRPGEEGAIlTLAGKYSAV 86
Cdd:pfam01459  97 TQFVPGKK-SGKLELDYKGDDFTASLKVGL----LAGPVVVGSYLQGVTG-LALGAEASYDTASGKLTKY-NAALGYTAR 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10434458    87 HWVATLNVGS--GGAHASYYHRANEQVQVGVEFEANTRLQDTTFSFGYHLTLPQANMVfRGLVDSNWCVGAVLEKKMPPl 164
Cdd:pfam01459 170 DYIASLTLVNngGVLTASYYHKVSEKLEVGAELTLNFSSNENTVTIGYKYDLDKSTTV-KAKVNSNGKVGLLYEQKLRP- 247

                         170
                  ....*....|....*
gi 10434458   165 PVTLALGAFLNHWRN 179
Cdd:pfam01459 248 GVTLTLSAEVDHKKL 262
3a0801s07tom40 TIGR00989
mitochondrial import receptor subunit Tom40; The mitochondrial protein translocase (MPT) ...
 18-66 2.98e-04

mitochondrial import receptor subunit Tom40; The mitochondrial protein translocase (MPT) family, which brings nuclearly encoded preproteins into mitochondria, is very complex with 19 currently identified protein constituents.These proteins include several chaperone proteins, four proteins of the outer membrane translocase (Tom) import receptor, five proteins of the Tom channel complex, five proteins of the inner membrane translocase (Tim) and three "motor" proteins. This family is specific for the Tom40 proteins. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130062  Cd Length: 161  Bit Score: 39.49  E-value: 2.98e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 10434458    18 QFDGEYRGDDYTATLTLGNPDLI--GESVIMVAHFLQSLTHRLVLGGELVY 66
Cdd:TIGR00989 110 QFEHDHLGDDFSASLKAINPSFLekGLTGIFVGSYLQSVTPRLGLGLEALW 160
Porin3_VDAC cd07306
Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent ...
 101-175 3.85e-03

Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent anion channel (VDAC) regulates the flux of mostly anionic metabolites through the outer mitochondrial membrane, which is highly permeable to small molecules. VDAC is the most abundant protein in the outer membrane, and membrane potentials can toggle VDAC between open or high-conducting and closed or low-conducting forms. VDAC binds to and is regulated in part by hexokinase, an interaction that renders mitochondria less susceptible to pro-apoptotic signals, most likely by intefering with VDAC's capability to respond to Bcl-2 family proteins. While VDAC appears to play a key role in mitochondrially induced cell death, a proposed involvement in forming the mitochondrial permeability transition pore, which is characteristic for damaged mitochondria and apoptosis, has been challenged by more recent studies.


Pssm-ID: 132767 [Multi-domain]  Cd Length: 276  Bit Score: 36.80  E-value: 3.85e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 10434458 101 ASYYHRANEQVQVGVEFEANTRLQDTTFSFG--YHLtlpQANMVFRGLVDSNWCVGAVLEKKMPPLpVTLALGAFLN 175
Cdd:cd07306 186 GSYFHKVSPRLAVGAKVTWYSGTNETTFAVGgqYAL---DPDALVKAKVNNDGQLGLSYQHKLRPG-VTLTLSAGFD 258
Porin3_VDAC cd07306
Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent ...
 4-136 8.95e-03

Voltage-dependent anion channel of the outer mitochondrial membrane; The voltage-dependent anion channel (VDAC) regulates the flux of mostly anionic metabolites through the outer mitochondrial membrane, which is highly permeable to small molecules. VDAC is the most abundant protein in the outer membrane, and membrane potentials can toggle VDAC between open or high-conducting and closed or low-conducting forms. VDAC binds to and is regulated in part by hexokinase, an interaction that renders mitochondria less susceptible to pro-apoptotic signals, most likely by intefering with VDAC's capability to respond to Bcl-2 family proteins. While VDAC appears to play a key role in mitochondrially induced cell death, a proposed involvement in forming the mitochondrial permeability transition pore, which is characteristic for damaged mitochondria and apoptosis, has been challenged by more recent studies.


Pssm-ID: 132767 [Multi-domain]  Cd Length: 276  Bit Score: 36.03  E-value: 8.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10434458   4 TVYaKTQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESvimvahFLQSLTHRLVLGGELvyHRRPGEEGAILTLAGKY 83
Cdd:cd07306 149 VVY-DTAKSKFTKYNFALGYTNGDFELSLKLNNGKTLRGS------YFHKVSPRLAVGAKV--TWYSGTNETTFAVGGQY 219

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 10434458  84 sAVHWVATLNV---GSGGAHASYYHRANEQVQVGVEFEANTR-LQDTTFSFGYHLTL 136
Cdd:cd07306 220 -ALDPDALVKAkvnNDGQLGLSYQHKLRPGVTLTLSAGFDAKnLNQGGHKFGLSLSL 275
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH