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Conserved domains on  [gi|1043377927|ref|YP_009266272|]
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NADH dehydrogenase subunit 2 (mitochondrion) [Yunnanacris yunnaneus]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475933)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-339 3.37e-87

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 265.53  E-value: 3.37e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927   1 MTNNSTKLLFLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNTMMNESSIKYFIVQAMASTMLLFSILLIQM 80
Cdd:MTH00160    1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  81 KYPMSWEmelIPSMMVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYCIQlSTFMFVIIILSIII 160
Cdd:MTH00160   81 NLMLFNN---ISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLIN-NNFIIIIIILSAII 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 161 GALGGLNQTSLRQLLAYSSISHLGWMISSLMVSENVWELYFIIYSLLSMILVLLFKQMNLFFLNQIYSSTNMKTEIKFMM 240
Cdd:MTH00160  157 GAIGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 241 FLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTMMVMLTMITLYYYMRISFSALILSYSENSWSMINMLKKPSFTLT 320
Cdd:MTH00160  237 FLNLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILN 316

                         330
                  ....*....|....*....
gi 1043377927 321 MMVMISTLGLMSTSMLVYL 339
Cdd:MTH00160  317 FLSFISLFGLILSSLLFLL 335
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-339 3.37e-87

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 265.53  E-value: 3.37e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927   1 MTNNSTKLLFLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNTMMNESSIKYFIVQAMASTMLLFSILLIQM 80
Cdd:MTH00160    1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  81 KYPMSWEmelIPSMMVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYCIQlSTFMFVIIILSIII 160
Cdd:MTH00160   81 NLMLFNN---ISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLIN-NNFIIIIIILSAII 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 161 GALGGLNQTSLRQLLAYSSISHLGWMISSLMVSENVWELYFIIYSLLSMILVLLFKQMNLFFLNQIYSSTNMKTEIKFMM 240
Cdd:MTH00160  157 GAIGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 241 FLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTMMVMLTMITLYYYMRISFSALILSYSENSWSMINMLKKPSFTLT 320
Cdd:MTH00160  237 FLNLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILN 316

                         330
                  ....*....|....*....
gi 1043377927 321 MMVMISTLGLMSTSMLVYL 339
Cdd:MTH00160  317 FLSFISLFGLILSSLLFLL 335
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 24-270 1.85e-19

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 86.98  E-value: 1.85e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  24 SNSWFGVWMGLEINLLSFIPMLA-NNKNTMMNESSIKYFIVQAMASTMLLFSILLI--------------QMKYPMSWEM 88
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGyWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMynytgtlsfdelskALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  89 ELIPSMMVSSSLLLKIGAAPFHFWFPEV-MGTSTWINCLMLMTWQKIAPMMVL-------SYCIQLSTFMFVIIILSIII 160
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAyEGAPTPVSALLAATLVKAGGYGLIrrsllylPSSPFIQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 161 GALGGLNQTSLRQLLAYSSISHLGWMISSLMV----SENVWELYFIIYSLLSMILVLLF-----KQMNLFFLNQIYSSTN 231
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAgtiyGIQAAIFHLLTHGLFSAGLFLCAgsviyRRVHTRNIRDYGGLAK 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1043377927 232 MKTEIKFMMFLSLLSLGGLPPFLGFLPKWIVMQSLVENN 270
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAAS 279
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 8-292 3.40e-12

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 66.90  E-value: 3.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927   8 LLFLSTLmmGTILSISSNSWFGVWMGLEI-NLLSFIPMLANNKNTMMNESSIKYFIVQAMASTMLLFSILLI-------- 78
Cdd:TIGR01770 107 LLLFALL--GIFLLVSSNDLLSIYLGLELqSLCFYVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIygftgsln 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  79 --QMKYPMSWEMELIPSM-----MVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIA---PMMVLSYCIQ--- 145
Cdd:TIGR01770 185 feDLLLFLSNGMLNISLLllgivLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAifaVFLRLFLYILfgf 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 146 ---LSTFMFVIIILSIIIGALGGLNQTSLRQLLAYSSISHLGWMISSLMVSENVWE----LYFIIYSLLSMILVLLFKQM 218
Cdd:TIGR01770 265 seaWQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEGIkavlFYIFIYALMSLGAFGVLSLL 344

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 219 NLFFLNQIYSSTNMKTEIK------FMMFLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTMMVMLTMITLYYYMRI 292
Cdd:TIGR01770 345 RSYKDEWIEYISDFAGLFKtnpilaILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRV 424
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 8-292 6.01e-10

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 60.13  E-value: 6.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927   8 LLFLSTLmmGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNTMM-NESSIKYFIVQAMASTMLLFSILLI-------- 78
Cdd:COG1007   107 LLLFATL--GMMLMASANDLLTLFLGLELLSLSLYVLVAFRRDDRRsSEAALKYFLLGALSSGFLLYGISLLygatgsln 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  79 ------QMKYPMSWEMELIPSM-MVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVL---------SY 142
Cdd:COG1007   185 lagiaaALAAGGANSPLLLLGLvLVLAGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALlrllveafpGL 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 143 CIQLSTFMFVIIILSIIIGALGGLNQTSLRQLLAYSSISHLGWMISSLMV-SENVWE---LYFIIYSLlsmilvllfkqM 218
Cdd:COG1007   265 AADWQLLLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAgTPLGVSaalFYLLAYLF-----------M 333

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 219 NL---FFLNQIYSSTNMKTEIK-------------FMMFLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTMMVMLT 282
Cdd:COG1007   334 NLgafAVILLLSRKGGEAEEIEdlaglarrspllaLAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNS 413

                         330
                  ....*....|
gi 1043377927 283 MITLYYYMRI 292
Cdd:COG1007   414 VISAYYYLRV 423
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-339 3.37e-87

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 265.53  E-value: 3.37e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927   1 MTNNSTKLLFLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNTMMNESSIKYFIVQAMASTMLLFSILLIQM 80
Cdd:MTH00160    1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  81 KYPMSWEmelIPSMMVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYCIQlSTFMFVIIILSIII 160
Cdd:MTH00160   81 NLMLFNN---ISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYLIN-NNFIIIIIILSAII 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 161 GALGGLNQTSLRQLLAYSSISHLGWMISSLMVSENVWELYFIIYSLLSMILVLLFKQMNLFFLNQIYSSTNMKTEIKFMM 240
Cdd:MTH00160  157 GAIGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 241 FLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTMMVMLTMITLYYYMRISFSALILSYSENSWSMINMLKKPSFTLT 320
Cdd:MTH00160  237 FLNLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILN 316

                         330
                  ....*....|....*....
gi 1043377927 321 MMVMISTLGLMSTSMLVYL 339
Cdd:MTH00160  317 FLSFISLFGLILSSLLFLL 335
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 3-340 6.36e-51

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 172.42  E-value: 6.36e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927   3 NNSTKLLFLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNTMMNESSIKYFIVQAMASTMLLFSILlIQMKY 82
Cdd:MTH00041    2 NRNVLIFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGAL-IQAWL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  83 PMSW----EMELIPSMMVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYCIQL--STFMFVIIIL 156
Cdd:MTH00041   81 SGSWsingPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISNLlnSNILILCGIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 157 SIIIGALGGLNQTSLRQLLAYSSISHLGWMISSLMVSENVWELYFIIYSLLSMILVLLFKQMNLFFLNQIYSSTNMKTEI 236
Cdd:MTH00041  161 SVLVGGWGGLNQTQTRKILAFSSIAHLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLNKLSQLNPIS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 237 KFMMFLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTMMVMLTMITLYYYMRISFSALILSYSENSWSMINMLKKPS 316
Cdd:MTH00041  241 AFLFILSILSLGGLPPLTGFLNKFISLYCLIQNNSILISIILIIGSLLSLFFYLRISFNTSLTLFPQHSISLFSWRNSGN 320

                         330       340
                  ....*....|....*....|....*....
gi 1043377927 317 FT-----LTMMVMISTLGLMSTSMLVYLY 340
Cdd:MTH00041  321 ITvygviLSILSSISILGLLLIPLFLSFL 349
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 6-336 3.45e-49

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 168.08  E-value: 3.45e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927   6 TKLLFLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNTMMNESSIKYFIVQAMASTMLLFSIlLIQMKYPMS 85
Cdd:MTH00112    5 AKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSS-TTNAWNTGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  86 WEMEL----IPSMMVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYCIQL--STFMFVIIILSII 159
Cdd:MTH00112   84 WDITQltnpTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLLMTSNSlnPTLLLTLAILSTL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 160 IGALGGLNQTSLRQLLAYSSISHLGWMISSLMVSENVWELYFIIYSLLSMILVLLFKQMNLFFLNQIYSSTNMKTEIKFM 239
Cdd:MTH00112  164 IGGWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSPTLNTT 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 240 MFLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTMMVMLTMITLYYYMRISFSALILSysenSWSMINMLKKPSFTL 319
Cdd:MTH00112  244 LMLTLLSLAGLPPLTGFMPKWLILQELTKQNMTPTATIMAMLSLLSLFFYLRLTYISTITL----PPNTTNMMMKWRTKP 319

                         330
                  ....*....|....*..
gi 1043377927 320 TMMVMISTLGLMSTSML 336
Cdd:MTH00112  320 KKNTLTATLTTLSTLLL 336
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 8-340 5.89e-48

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 164.63  E-value: 5.89e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927   8 LLFLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNTMMNESSIKYFIVQAMASTMLLFSIlLIQMKYPMSWE 87
Cdd:MTH00105    7 IIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAI-IINLMYSGQWT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  88 MELIP----SMMVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLsYCIQLS---TFMFVIIILSIII 160
Cdd:MTH00105   86 ITKLTnptaSTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSIL-YQISPSinpNLLLTLAILSILI 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 161 GALGGLNQTSLRQLLAYSSISHLGWMISSLMVSENVWELYFIIYSLLSMILVLLFKQMNLFFLNQIYSSTNMKTEIKFMM 240
Cdd:MTH00105  165 GGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLMTSLI 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 241 FLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTMMVMLTMITLYYYMRISFS-ALILSYSENSWSMINMLK--KPSF 317
Cdd:MTH00105  245 LLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYStSLTMFPSTNNMKMKWQFEntKPMT 324

                         330       340
                  ....*....|....*....|...
gi 1043377927 318 TLTMMVMISTLGLMSTSMLVYLY 340
Cdd:MTH00105  325 LLPTLIILSTMLLPLTPMLSILE 347
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 10-340 3.80e-46

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 160.09  E-value: 3.80e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  10 FLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNTMMNESSIKYFIVQAMASTMLLFSILlIQMKYPMSWEM- 88
Cdd:MTH00070    9 LLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSST-INAWFTGEWTIm 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  89 ---ELIPSMMVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYCIQL--STFMFVIIILSIIIGAL 163
Cdd:MTH00070   88 nmqTPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALLIQISHLlnSNLLIIMGLLSTLIGGW 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 164 GGLNQTSLRQLLAYSSISHLGWMISSLMVSENVWELYFIIYSLLSMILVLLFKQMNLFFLNQIYSSTNMKTEIKFMMFLS 243
Cdd:MTH00070  168 GGLNQTQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSKNPTLTSMMMLT 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 244 LLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTMMVMLTMITLYYYMRISFsALILSYS---ENSWSMINMLKKPSFTLT 320
Cdd:MTH00070  248 LLSLGGLPPTTGFIPKWLILQELTKQNLTTLATLMALSALLSLFFYLRLSY-AMSLTTSpntSNSKLYWRFKNKTNNLLS 326

                         330       340
                  ....*....|....*....|
gi 1043377927 321 MMVMISTLGLMSTSMLVYLY 340
Cdd:MTH00070  327 LTIILSLMLLPITPTILNLF 346
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 9-328 2.92e-44

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 154.44  E-value: 2.92e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927   9 LFLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNTMMNESSIKYFIVQAMASTMLLFSILLIQMKYPMSwem 88
Cdd:MTH00197    2 LFLFIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSLSFSNLYLS--- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  89 eLIPSMMVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYCIQLSTFMFVIIILSIIIGALGGLNQ 168
Cdd:MTH00197   79 -LLSVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNSSSFMGLLICSVLSSLIGGIGGMNQ 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 169 TSLRQLLAYSSISHLGWMISSLMVSENVWELYFIIYSLLSMILVLLFKQMNLFFLNQIYSSTNMKTEIKFMMFLSLLSLG 248
Cdd:MTH00197  158 SNIRQLLAYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQQYSNPESMSSNLVFLGLSFLSLG 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 249 GLPPFLGFLPKWIVMQSLVENNMTIMMTMMVMLTMITLYYYMRISFSALILSYSENSWSMINMLKKPSFTLTMMVMISTL 328
Cdd:MTH00197  238 GLPPLSGFFLKWLILTSLLSSNISLITFMLILSTCFSLYYYLSLAYKSLILSNWMINFLMKINLLYSGLFILLMMMLPLL 317
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 6-339 9.27e-44

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 153.59  E-value: 9.27e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927   6 TKLLFLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNTMMNESSIKYFIVQAMASTMLLFSILLIQM---KY 82
Cdd:MTH00200    5 ILPLFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWtsgQW 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  83 PMSWEMELIPSMMVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLS--YCIQLSTFMFVIIILSIII 160
Cdd:MTH00200   85 GISEMLGPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIqlAPALNSNILLLLGLLSVLV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 161 GALGGLNQTSLRQLLAYSSISHLGWMISSLMVSENVWELYFIIYSLLSMILVLLFKQMNLFFLNQIYSSTNMKTEIKFMM 240
Cdd:MTH00200  165 GGWGGLNQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNPILSMLL 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 241 FLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTMMVMLTMITLYYYMRISFSALILSYSENSWSMINMLKK--PSFT 318
Cdd:MTH00200  245 GLTLLSLGGLPPLTGFFPKWLILQELSKQGLFIYATILLLGSLLSLFFYLRLSYLTLLTLSPNQINMMSSWRTKsnSNLL 324

                         330       340
                  ....*....|....*....|.
gi 1043377927 319 LTMMVMISTLGLMSTSMLVYL 339
Cdd:MTH00200  325 VGLLLLLSILGLPLTPQLLFL 345
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 7-322 3.88e-42

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 148.88  E-value: 3.88e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927   7 KLLFLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNTMMNESSIKYFIVQAMASTMLLFSIlLIQMKYPMSW 86
Cdd:MTH00144    6 NLLFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGS-LIMYNLSFSW 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  87 EMelipSMMVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYCI---QLSTFMFVIIILSIIIGAL 163
Cdd:MTH00144   85 FS----MSLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLdlyWLAYLLCVISVLSALVGSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 164 GGLNQTSLRQLLAYSSISHLGWMISSLMVSENVWELYFIIYSLLSMILVLLFKQMNLFFLNQIYSSTNMKTEIKFMMFlS 243
Cdd:MTH00144  161 GGLNQTQVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGSLKPSYKTGLSIIS-L 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1043377927 244 LLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTMMVMLTMITLYYYMRISFSALILSYSENSWSMINMLKKPSFTLTMM 322
Cdd:MTH00144  240 LLSLGGLPPFLGFCSKLLVLISSMESSPLLLILLLLLGSLISLFFYLSVFFSSFLSSSKSKKSNSSKVLNSSIISLNLL 318
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 6-300 4.94e-40

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 143.38  E-value: 4.94e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927   6 TKLLFLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNTMMNESSIKYFIVQAMASTMLLFSIlliQMKYPMS 85
Cdd:MTH00011    7 TMFLFSSTMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGM---TMMWSFP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  86 WEMELIPSMMVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYC--IQLSTFMFVIIILSIIIGAL 163
Cdd:MTH00011   84 SLLKNITALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFtsHNILPMMTSMAAMSALAGGL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 164 GGLNQTSLRQLLAYSSISHLGWMISSLMVSENVWELYFIIYSLLSMILVLLFKQMNLFFLNQIYSSTNMKTEIKFMMFLS 243
Cdd:MTH00011  164 GGMNQTQLRPLLAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSMSQTTSMSLFIM 243

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1043377927 244 LLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTMMVMLTMITLYYYMRISFSALILS 300
Cdd:MTH00011  244 LLSLGGLPPFTGFMPKLMAIETLTSNSMILILLVLIVGSLMNLFYYLNLIFNFMYLS 300
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 9-336 2.15e-39

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 142.25  E-value: 2.15e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927   9 LFLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNTMMNESSIKYFIVQAMASTMLLFSIL----------LI 78
Cdd:MTH00135    8 ILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTtnawltgqwdIQ 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  79 QMKYPmswemelIPSMMVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLsycIQL----STFMFVII 154
Cdd:MTH00135   88 QMSHP-------LPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALI---LQIaptnPTLLITLG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 155 ILSIIIGALGGLNQTSLRQLLAYSSISHLGWMISSLMVSENVWELYFIIYSLLSMILVLLFKQMNLFFLNQIYSSTNMKT 234
Cdd:MTH00135  158 LTSTLVGGWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAP 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 235 EIKFMMFLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTMMVMLTMITLYYYMRISFsALILSYSENSWSMINMLKK 314
Cdd:MTH00135  238 ALTALTPLILLSLGGLPPLTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRLSY-AMTLTISPNTLNGTTPWRL 316

                         330       340
                  ....*....|....*....|..
gi 1043377927 315 PSFTLTMMVMISTlgLMSTSML 336
Cdd:MTH00135  317 PSTQLTLPLAIST--TATLMLL 336
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 24-270 1.85e-19

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 86.98  E-value: 1.85e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  24 SNSWFGVWMGLEINLLSFIPMLA-NNKNTMMNESSIKYFIVQAMASTMLLFSILLI--------------QMKYPMSWEM 88
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGyWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMynytgtlsfdelskALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  89 ELIPSMMVSSSLLLKIGAAPFHFWFPEV-MGTSTWINCLMLMTWQKIAPMMVL-------SYCIQLSTFMFVIIILSIII 160
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAyEGAPTPVSALLAATLVKAGGYGLIrrsllylPSSPFIQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 161 GALGGLNQTSLRQLLAYSSISHLGWMISSLMV----SENVWELYFIIYSLLSMILVLLF-----KQMNLFFLNQIYSSTN 231
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAgtiyGIQAAIFHLLTHGLFSAGLFLCAgsviyRRVHTRNIRDYGGLAK 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1043377927 232 MKTEIKFMMFLSLLSLGGLPPFLGFLPKWIVMQSLVENN 270
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAAS 279
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 16-319 7.30e-18

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 83.54  E-value: 7.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  16 MGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNTMMN-ESSIKYFIVQAMASTMLLFSI----------------LLI 78
Cdd:MTH00196    4 LGILCLISSSNWLSVYLAIELQTLSLFILIAQNRGSGYSaEAGLKYFVLGALSSGLFLFGCallcgttgglhlsyinLVL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  79 QMKYPMSWEMELIPSMMVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYCIQLSTFMFVIIILSI 158
Cdd:MTH00196   84 NSGQSFSSVSVPIGYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGLNVNILLIGGLFSL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 159 IIGALGGLNQTSLRQLLAYSSISHLGWMISSLMV----SENVWELYFIIYSLLS----MILVLLFKQMNLFFLNQIYSST 230
Cdd:MTH00196  164 FVGAIGALNQTKIKRLLAYSGIGHMGFVLWGIEIgsfeSIQASLVYLFIYIIMSicvfSIILALNVYKNLIIEFSGLSRR 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 231 NMKTEIKFMMflSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTMMVMLTMITLYYYMRIsfsALILSYSENSWSMI- 309
Cdd:MTH00196  244 LPILAITLAL--TFLSIAGIPPLVGFLGKWLILLSGVVYQYYLIFLLAVFCSVIAGVYYVRI---VKILFFQANSFLLIs 318

                         330
                  ....*....|.
gi 1043377927 310 -NMLKKPSFTL 319
Cdd:MTH00196  319 tKILKKENKIN 329
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 16-220 5.77e-15

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 75.44  E-value: 5.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  16 MGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNTMMN-ESSIKYFIVQAMASTMLLFSILLIqmkYPMSWEMEL---- 90
Cdd:MTH00199  108 LGSLLLVSSINWLSIYLAIELQTLTLFILVALKRDSAYStEAGLKYFVLGAVSSGLFLFGCALL---YGLTGETSIqgin 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  91 ------IPSMMVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYCIQLSTFMFVIIILSIIIGALG 164
Cdd:MTH00199  185 siltgdVGKILITISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSILVQIGPVTNVVLICAVLSIIYGAIG 264

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 165 GLNQTSLRQLLAYSSISHLGWMISSLMVSEN----VWELYFIIYSLLSMILVLLFKQMNL 220
Cdd:MTH00199  265 ALNQTKIKRLLAYSGIGHMGFILFGVAIGSFesiqASLIYMIIYVIMSICSFSIILSLKL 324
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
8-187 7.81e-13

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 69.08  E-value: 7.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927   8 LLFLSTLmmGTILSISSNSWFGVWMGLEINLLSFIPMLA-NNKNTMMNESSIKYFIVQAMASTMLLFSILLI-------- 78
Cdd:PRK05777  108 LVLFALL--GMMVMVSANDLLTLFLGLELLSLPLYALAAlRRDRRRSLEAAIKYFVLGALASGFLLYGMSLLygatgsls 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  79 ------QMKYPMSWEMELIPSM-MVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVL---------SY 142
Cdd:PRK05777  186 fagiakALADGSGNSLLLLFGLvFLLVGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAVLlrllvvafgGL 265

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1043377927 143 CIQLSTFMFVIIILSIIIGALGGLNQTSLRQLLAYSSISHLGWMI 187
Cdd:PRK05777  266 SEDWQQVLAIIAIASMLVGNLAALSQTNIKRLLAYSSIAHAGYLL 310
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 8-292 3.40e-12

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 66.90  E-value: 3.40e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927   8 LLFLSTLmmGTILSISSNSWFGVWMGLEI-NLLSFIPMLANNKNTMMNESSIKYFIVQAMASTMLLFSILLI-------- 78
Cdd:TIGR01770 107 LLLFALL--GIFLLVSSNDLLSIYLGLELqSLCFYVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGISLIygftgsln 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  79 --QMKYPMSWEMELIPSM-----MVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIA---PMMVLSYCIQ--- 145
Cdd:TIGR01770 185 feDLLLFLSNGMLNISLLllgivLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAifaVFLRLFLYILfgf 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 146 ---LSTFMFVIIILSIIIGALGGLNQTSLRQLLAYSSISHLGWMISSLMVSENVWE----LYFIIYSLLSMILVLLFKQM 218
Cdd:TIGR01770 265 seaWQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEGIkavlFYIFIYALMSLGAFGVLSLL 344

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 219 NLFFLNQIYSSTNMKTEIK------FMMFLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTMMVMLTMITLYYYMRI 292
Cdd:TIGR01770 345 RSYKDEWIEYISDFAGLFKtnpilaILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRV 424
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 8-292 6.01e-10

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 60.13  E-value: 6.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927   8 LLFLSTLmmGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNTMM-NESSIKYFIVQAMASTMLLFSILLI-------- 78
Cdd:COG1007   107 LLLFATL--GMMLMASANDLLTLFLGLELLSLSLYVLVAFRRDDRRsSEAALKYFLLGALSSGFLLYGISLLygatgsln 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  79 ------QMKYPMSWEMELIPSM-MVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVL---------SY 142
Cdd:COG1007   185 lagiaaALAAGGANSPLLLLGLvLVLAGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALlrllveafpGL 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 143 CIQLSTFMFVIIILSIIIGALGGLNQTSLRQLLAYSSISHLGWMISSLMV-SENVWE---LYFIIYSLlsmilvllfkqM 218
Cdd:COG1007   265 AADWQLLLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAgTPLGVSaalFYLLAYLF-----------M 333

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 219 NL---FFLNQIYSSTNMKTEIK-------------FMMFLSLLSLGGLPPFLGFLPKWIVMQSLVENNMTIMMTMMVMLT 282
Cdd:COG1007   334 NLgafAVILLLSRKGGEAEEIEdlaglarrspllaLAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNS 413

                         330
                  ....*....|
gi 1043377927 283 MITLYYYMRI 292
Cdd:COG1007   414 VISAYYYLRV 423
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 16-187 1.84e-09

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 58.72  E-value: 1.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  16 MGTILSISSNSWFGVWMGLEINLLSFIPM---------LANNKNTMMNESSIKYFIVQAMASTMLLFSILL--------- 77
Cdd:MTH00198  199 LGGLLLIESANWLTIYLALEFQTLALFILagegsqpgsHFPSPGNTPPESGLKYWILGAMSSGFYLFGCALyfgftgneg 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  78 ----IQMKYPMSWEMEL----IPSMMVSSSLLLKIGAAPFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLSYCIQLSTF 149
Cdd:MTH00198  279 mlgtILSATLETTNIELrqgsLGYLFITVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYILLTSLVITSKL 358

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1043377927 150 MFVIIILSIIIGALGGLNQTSLRQLLAYSSISHLGWMI 187
Cdd:MTH00198  359 LLSVAIISLVVGAFGALNQTRIKRLLAYSGIGHIGFIL 396
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 10-187 4.32e-07

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 51.30  E-value: 4.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  10 FLSTLMMGTILSISSNSWFGVWMGLEINLLSFIPMLANNKNTMMNESSIKYFIVQAMASTMLLFSILLIQMKY------P 83
Cdd:COG0651   112 LFLLLLAGMNGAFLTGDLFNLFVFFEVMLLASYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVGLLYGATgtlnmaD 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  84 MSWEMELIPSMMVSSSLLL-------KIGAAPFHFWFPEVMGT-STWINCLM--LMTwqKIAPMMVL---------SYCI 144
Cdd:COG0651   192 LAARLAELDPGLLLAAFALllvgfgiKAALFPLHFWLPDAYPAaPSPVSALLsgLLT--KVGVYAILrvltllfgaDPAL 269

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1043377927 145 QLSTFMFVIIILSIIIGALGGLNQTSLRQLLAYSSISHLGWMI 187
Cdd:COG0651   270 FLGTLLLVLGLLTMLVGALGALAQRDLKRLLAYSSVSQIGYIL 312
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 55-193 5.27e-05

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 44.70  E-value: 5.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  55 ESSIKYFIVQAMASTMLLFSILLIQMKYPmSWEMELIPSMMVSS--------------SLLLKIGAAPFHFWFPEVMGTS 120
Cdd:PRK08376  172 EAGIKYMFVGSLASSMVLLGIALLYGQYG-TLNMAYLAVKMSENptvvakialalfiaGLAMKSGAVPVHMWLPDAYPAA 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 121 -TWINCLMLMTWQ-KIAPMMVLSYCIQLSTF--------MFVIIILSIIIGALGGLNQTSLRQLLAYSSISHLGWMISSL 190
Cdd:PRK08376  251 pSSISAMLLVIKQaGLYALARVLFSIYGPAInlatvgwvIIILGCLTMFVGVAMAVVQKDVKRLLAYHSVSQIGYMLLGL 330


                  ...
gi 1043377927 191 MVS 193
Cdd:PRK08376  331 GVG 333
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 8-187 8.89e-04

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 41.08  E-value: 8.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927   8 LLFLSTLMMGTILSISSNSWFGVWmglEINLLSFIPMLANNKNTMMNESSIKYFIVQAMASTMLLFSILLIQMKYPMSW- 86
Cdd:TIGR01972 112 LLLLEAGVIGVFLALDLFLFYVFW---EAMLIPMYLLIGVWGGPNRIYAAMKFFLYTLAGSLLMLLAILGLYFLGGGTFd 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  87 ---EMELIPSMMVSSSLLLKIGAA--------PFHFWFPEVMGTSTWINCLMLM-TWQKIAPMMVLSYCIQL-------- 146
Cdd:TIGR01972 189 lleLLNLPLPFGVQTWLFLAFFIAfavkvplfPLHTWLPDAHVEAPTAGSVILAgVLLKMGTYGFLRFNLPLfpdaslyf 268

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1043377927 147 STFMFVIIILSIIIGALGGLNQTSLRQLLAYSSISHLGWMI 187
Cdd:TIGR01972 269 APVLAALGVIAIIYGALIALAQTDIKRLIAYSSISHMGFVL 309
PRK12650 PRK12650
DUF4040 family protein;
108-192 1.69e-03

DUF4040 family protein;


Pssm-ID: 237158 [Multi-domain]  Cd Length: 962  Bit Score: 40.41  E-value: 1.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 108 PFHFWFPEVMGTSTWINCLMLMTWQKIAPMMVLsycIQLSTFM----------FVIIILSIIIGALGGLNQTSLRQLLAY 177
Cdd:PRK12650  226 PFHFWLPEAMAAITPVSAFLHAAAVVKAGIYLL---LRFSPVFhdvavwnwllIIVGMITALMGAVFAVQKTDLKKLTAY 302

                          90
                  ....*....|....*
gi 1043377927 178 SSISHLGWMISSLMV 192
Cdd:PRK12650  303 STVSQLGWIVATIGV 317
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 34-187 4.57e-03

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 38.71  E-value: 4.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927  34 LEINLLSFIPMLANNKNTMMNESSIKYFIVQAMASTMLLFSILLIqmkYPM--SWEMELIPSM------------MVSSS 99
Cdd:PRK08375  135 LEIMSLSSYALVAMGGDRRALAAARKYLIVGLIGSTFLLIGVGLL---YGVtgTLNMADLAGAlaenptvvtafgFVLLA 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1043377927 100 LLLKIGAAPFHFWFPEVM-GTSTWINCL---------------MLMTWQKIAPMMVLSYCIQLSTFMFViiilSIIIGAL 163
Cdd:PRK08375  212 LALKAAVFPLHTWLPRAYpAAPPVVTALlsglvtkvavyalirIYFTVFGGDFRFALGLGWLLAVLALL----SMLVGSL 287

                         170       180
                  ....*....|....*....|....
gi 1043377927 164 GGLNQTSLRQLLAYSSISHLGWMI 187
Cdd:PRK08375  288 AALGQDDVKRVLAYSTVSQMGYIL 311
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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