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Conserved domains on  [gi|1042791390|gb|ANQ51957|]
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TonB-dependent receptor [Flammeovirga sp. MY04]

Protein Classification

SusC/RagA family TonB-linked outer membrane protein( domain architecture ID 11499350)

SusC/RagA family TonB-linked outer membrane protein might act as a TonB-dependent receptor similar to Bacteroides thetaiotaomicron starch-utilization system protein C (SusC), which mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation

CATH:  1.25.40.390
Gene Ontology:  GO:0009279|GO:0016020
PubMed:  15111112|28077872|11717282|17965357

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 29-1035 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


:

Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 887.71  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390   29 RTITGTIHDENNEPLIGANILIEGTTNGTIADFDGKYHLEVPEGtNNIVVSFVGYLSQTIAIGTRSVIDVVLEADAEQLE 108
Cdd:TIGR04056    1 ITVTGVVVDETGEPLIGASVVVKGTTNGTITDIDGNFSLKVPPG-AVLVFSYIGYKTQEVKVKGQKNLNITLKEDTQELD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  109 EVIVVGYGTQEKVNVTGSVAQVDSEVLSAVPTPDAIGALQGRIAGVTVNPGQG-PGATPTIRVRGVTSMSGSNDPLIVID 187
Cdd:TIGR04056   80 EVVVVGYGTQKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGePGGDAEIWIRGISSFGGNNSPLYVID 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  188 GIPSTvENFATLANSDIETISVLKDAASASIYGARAAAGVILVTTKRGKTGEPTVTYDGYVAMQSMTTTPNYMNSLQYME 267
Cdd:TIGR04056  160 GVPRD-NGLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGKEGKPKISYNAEFGFSTPTRLPEMLNAYEYAE 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  268 AVNRGFTAQG--GNEFYTEQHFETVRNGGD-HLMGQFDWWDAVYRDNAPQQSHYVNVTGGTEKTKYLASVGYMDQQGFYQ 344
Cdd:TIGR04056  239 LYNEALLNRGssPPDIYTDEEIEAYRNGLDpDLYPNTDWQDEIFKRTAFNQRHNLSVSGGTEKARYYVSLGYYNEEGILK 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  345 TENYfKRYNTRLNITTELSKRLKATAQMNFTRQEQQ----DTGDSWRAtqALAMVPLNPI----YNQDGTYNITRPVDNT 416
Cdd:TIGR04056  319 NSDY-KRYNFRANIDAKLTKTLKLSLNVSGSLSKYNnpggSTSNIWGA--LMLFPRGTPYstppVYSDGYYPAYNSGNTS 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  417 RFeNTLAHMKLSDYIRKVNQLQSFLSLDYEIAKNLTVTGRTSMNFRSFEQNHfqqgYQFVHSHNNAVGLNLQSAAAEDWN 496
Cdd:TIGR04056  396 LQ-NPYALLNRGYNENERNRLNGNASLEQKITKGLKLKGTFSYDYSNYKNKK----YYKNPYYYNATGGANNGYYSESNS 470

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  497 NSMRVVNDLVMNYHVDFGKHHIGALVGIAEEFFRYDRLYGRRVNFANnqlrkiIAGGQAGQIAESNAYDWALQSQFARIN 576
Cdd:TIGR04056  471 RSRNYYLEATLNYNRTFGKHNVSALLGYSQQENKSSSYGGLLDDLPS------LDAGTSDASVSGSDSEYRLQSLFGRAT 544

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  577 YDYDKKYLLEVNVRRDVSSRFHKDNRAGVFPSVSVGWRIAEEDFFKDNvsENFISDIKFRGSVGSLGNQNINNsavsnlY 656
Cdd:TIGR04056  545 YSYKDRYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEEKFMKKL--KKWLSFLKLRASYGIVGNDNIGD------R 616

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  657 YPYMGVISAADYPYNNELVMGK-----AQNEMPVPGLKWETTVTYNAGIDIDFLDGKLGTSFDYFKKITSDMLLPLPMSA 731
Cdd:TIGR04056  617 YPYLSLYNLGDGGYNFGTNNGTsvtgiTESRYGNPNLKWEKTKKWNLGLDLGFFNNRLSLTVDYYYKKTKDILQSRSLPS 696

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  732 VGGLGNPWENAATLENTGWEFDIRYSNTTKSGFTYGIGANISHFTNVLTDLAGG---FSEYSNQFREGDPIGTIYGYRTK 808
Cdd:TIGR04056  697 VTGYSSPYANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILELDEGaylPVKYPYISKEGGPIGQIYGYIAD 776

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  809 GIYRDQAHVDADNAkladaslkngvaqtrNVMLGDLIYEDINGDGIINHEDMVAIGNT-LPKYQFGITFDFAYKNFDLSM 887
Cdd:TIGR04056  777 GLFKDDDSPKQTFG---------------NVRPGDIKYKDVNGDGKIDDDDRVPIGYSnTPDLTYGFGNSFSYKGFDLSA 841

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  888 FWQGAAD----IDGYVGYNVFAGNKDSNLRDFYTDAYHPDlNPNGAYPRFSPDE--NSQNHEVNDFWVQSASYLRLKNLQ 961
Cdd:TIGR04056  842 LFQGSGGgdvfNDGRGFYPFNGGDWGNVLKIVADNRWTPE-NPNADYPRLSYGDsnNSNNYQASTRWLEDGSYLRLKNLT 920

                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1042791390  962 IGYSLPKTVTDQMKIGKARVYLSGQNLLTITNFDeGFDPEMVApmnqdgsfqvgdVRPSFMPTVRVVSAGLQVT 1035
Cdd:TIGR04056  921 LGYTLPKKWLKKIGISNLRVYFSGQNLFTFSKYK-GWDPELQG------------NDGGAYPLQRTFSFGVNLT 981
 
Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 29-1035 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 887.71  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390   29 RTITGTIHDENNEPLIGANILIEGTTNGTIADFDGKYHLEVPEGtNNIVVSFVGYLSQTIAIGTRSVIDVVLEADAEQLE 108
Cdd:TIGR04056    1 ITVTGVVVDETGEPLIGASVVVKGTTNGTITDIDGNFSLKVPPG-AVLVFSYIGYKTQEVKVKGQKNLNITLKEDTQELD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  109 EVIVVGYGTQEKVNVTGSVAQVDSEVLSAVPTPDAIGALQGRIAGVTVNPGQG-PGATPTIRVRGVTSMSGSNDPLIVID 187
Cdd:TIGR04056   80 EVVVVGYGTQKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGePGGDAEIWIRGISSFGGNNSPLYVID 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  188 GIPSTvENFATLANSDIETISVLKDAASASIYGARAAAGVILVTTKRGKTGEPTVTYDGYVAMQSMTTTPNYMNSLQYME 267
Cdd:TIGR04056  160 GVPRD-NGLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGKEGKPKISYNAEFGFSTPTRLPEMLNAYEYAE 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  268 AVNRGFTAQG--GNEFYTEQHFETVRNGGD-HLMGQFDWWDAVYRDNAPQQSHYVNVTGGTEKTKYLASVGYMDQQGFYQ 344
Cdd:TIGR04056  239 LYNEALLNRGssPPDIYTDEEIEAYRNGLDpDLYPNTDWQDEIFKRTAFNQRHNLSVSGGTEKARYYVSLGYYNEEGILK 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  345 TENYfKRYNTRLNITTELSKRLKATAQMNFTRQEQQ----DTGDSWRAtqALAMVPLNPI----YNQDGTYNITRPVDNT 416
Cdd:TIGR04056  319 NSDY-KRYNFRANIDAKLTKTLKLSLNVSGSLSKYNnpggSTSNIWGA--LMLFPRGTPYstppVYSDGYYPAYNSGNTS 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  417 RFeNTLAHMKLSDYIRKVNQLQSFLSLDYEIAKNLTVTGRTSMNFRSFEQNHfqqgYQFVHSHNNAVGLNLQSAAAEDWN 496
Cdd:TIGR04056  396 LQ-NPYALLNRGYNENERNRLNGNASLEQKITKGLKLKGTFSYDYSNYKNKK----YYKNPYYYNATGGANNGYYSESNS 470

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  497 NSMRVVNDLVMNYHVDFGKHHIGALVGIAEEFFRYDRLYGRRVNFANnqlrkiIAGGQAGQIAESNAYDWALQSQFARIN 576
Cdd:TIGR04056  471 RSRNYYLEATLNYNRTFGKHNVSALLGYSQQENKSSSYGGLLDDLPS------LDAGTSDASVSGSDSEYRLQSLFGRAT 544

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  577 YDYDKKYLLEVNVRRDVSSRFHKDNRAGVFPSVSVGWRIAEEDFFKDNvsENFISDIKFRGSVGSLGNQNINNsavsnlY 656
Cdd:TIGR04056  545 YSYKDRYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEEKFMKKL--KKWLSFLKLRASYGIVGNDNIGD------R 616

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  657 YPYMGVISAADYPYNNELVMGK-----AQNEMPVPGLKWETTVTYNAGIDIDFLDGKLGTSFDYFKKITSDMLLPLPMSA 731
Cdd:TIGR04056  617 YPYLSLYNLGDGGYNFGTNNGTsvtgiTESRYGNPNLKWEKTKKWNLGLDLGFFNNRLSLTVDYYYKKTKDILQSRSLPS 696

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  732 VGGLGNPWENAATLENTGWEFDIRYSNTTKSGFTYGIGANISHFTNVLTDLAGG---FSEYSNQFREGDPIGTIYGYRTK 808
Cdd:TIGR04056  697 VTGYSSPYANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILELDEGaylPVKYPYISKEGGPIGQIYGYIAD 776

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  809 GIYRDQAHVDADNAkladaslkngvaqtrNVMLGDLIYEDINGDGIINHEDMVAIGNT-LPKYQFGITFDFAYKNFDLSM 887
Cdd:TIGR04056  777 GLFKDDDSPKQTFG---------------NVRPGDIKYKDVNGDGKIDDDDRVPIGYSnTPDLTYGFGNSFSYKGFDLSA 841

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  888 FWQGAAD----IDGYVGYNVFAGNKDSNLRDFYTDAYHPDlNPNGAYPRFSPDE--NSQNHEVNDFWVQSASYLRLKNLQ 961
Cdd:TIGR04056  842 LFQGSGGgdvfNDGRGFYPFNGGDWGNVLKIVADNRWTPE-NPNADYPRLSYGDsnNSNNYQASTRWLEDGSYLRLKNLT 920

                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1042791390  962 IGYSLPKTVTDQMKIGKARVYLSGQNLLTITNFDeGFDPEMVApmnqdgsfqvgdVRPSFMPTVRVVSAGLQVT 1035
Cdd:TIGR04056  921 LGYTLPKKWLKKIGISNLRVYFSGQNLFTFSKYK-GWDPELQG------------NDGGAYPLQRTFSFGVNLT 981
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
107-805 1.26e-45

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 175.02  E-value: 1.26e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  107 LEEVIVVGYGTQEKV-NVTGSVAQVDSEVLSAVPTPDAIGALQgRIAGVTVNPGQGPGATPTIRvrGVTSmsGSNDPLIV 185
Cdd:COG1629      1 LEEVVVTATRTDESLqDVPGSVSVISREQLEDQPATDLGDLLR-RVPGVSVTSAGGGAGQISIR--GFGG--GGNRVLVL 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  186 IDGIPST-----VENFATLANSDIETISVLKDAASAsIYGARAAAGVILVTTKRGKTGeptvtydgyvamqsmtttpnym 260
Cdd:COG1629     76 VDGVPLNdpsggDGGLSYIDPEDIERVEVLRGPSSA-LYGSGALGGVINIVTKKPKDG---------------------- 132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  261 nslqymeavnRGFTAQGGnefyteqhfetvrnggdhlMGQFDWwdavyrdnapqQSHYVNVTGGTEKTKYLASVGYMDQQ 340
Cdd:COG1629    133 ----------KGGEVSAS-------------------YGSYGT-----------YRASLSLSGGNGKLAYRLSASYRDSD 172

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  341 GFYQTENYfKRYNTRLNITTELSKRLKATAQMNFTRQEQQDTGDSWRATqalamvpLNPIYNQDGTYNitrpvdntrfen 420
Cdd:COG1629    173 GYRDNSDS-DRYNLRAKLGYQLGDDTRLTLSASYSDSDQDSPGYLTLAA-------LRPRGAMDDGTN------------ 232

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  421 tlahmKLSDYIRKVNQLQSFLSLDYE-IAKNLTVTGRTSmnFRSFEQNHFQQGYQFVHSHNNavglnlqsaAAEDWNNSM 499
Cdd:COG1629    233 -----PYSNDTDDNTRDRYSLSLEYEhLGDGLKLSASAY--YRYDDTDLDSDFTPTPADGGT---------LEQTDFDNR 296

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  500 RVVNDLVMNYHVDFGKHHIGaLVGIaeEFFRYDrlyGRRVNFANNQLRKIIAGGQAGQIAESNAYDWALqsqFARINYDY 579
Cdd:COG1629    297 TYGLELRLTYDLGFGGKHTL-LVGL--DYQRQD---LDGSGYPLDLGSGSLPTLTSGADDDGTTTSLAL---YAQDTYKL 367

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  580 DKKYLLEVNVRRDVSSRFHKDNRAG------------VFPSVSVGWRIAEEDFFKDNVSENFISdikfrGSVGSLGNQNI 647
Cdd:COG1629    368 TDKLTLTAGLRYDYVSYDVDDTVTGtdsasgsrsysaFSPSLGLTYQLSPNLSLYASYSRGFRA-----PTFGELYANGT 442

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  648 NNSAVSNlyypymgvisaadypynnelvmgkaqnempvPGLKWETTVTYNAGIDIDFLDGKLGTSFDYFKKITSDMLLPL 727
Cdd:COG1629    443 DPYSVGN-------------------------------PDLKPETSTNYELGLRYRLLDGRLSLSLALFYSDVDNEILSV 491

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1042791390  728 PMSAVGGLGNPWENAATLENTGWEFDIRYSNTtkSGFTygIGANISHFTNVLTDLAGGFSEYSNQFREGDPIGTIYGY 805
Cdd:COG1629    492 PLPNDSGFSTYYTNAGKARSYGVELELSYQLT--PGLS--LNASYSYTDAKFDDDTDGSADLDGNRLPGVPPLTANLG 565
CarbopepD_reg_2 pfam13715
CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, ...
 31-112 2.02e-20

CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.


Pssm-ID: 433425 [Multi-domain]  Cd Length: 88  Bit Score: 86.49  E-value: 2.02e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390   31 ITGTIHDEN-NEPLIGANILIEGTTNGTIADFDGKYHLE-VPEGTNNIVVSFVGY--LSQTIAIGTRSVIDV--VLEADA 104
Cdd:pfam13715    1 ISGTVVDENtGEPLPGATVYVKGTTKGTVTDADGNFELKnLPAGTYTLVVSFVGYktQEKKVTVSNDNTLDVnfLLKEDA 80


                   ....*...
gi 1042791390  105 EQLEEVIV 112
Cdd:pfam13715   81 LLLDEVVV 88
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 144-494 1.06e-10

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 65.55  E-value: 1.06e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  144 IGALQGRIAGVTVNPGQGPGATpTIRVRGVtsmsGSNDPLIVIDGIPSTVENFATLANSD------IETISVLKDAASAs 217
Cdd:cd01347     18 LADLLRRIPGVSVTRGGGGGGS-TISIRGF----GPDRTLVLVDGLPLASSNYGRGVDLNtippelIERVEVLKGPSSA- 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  218 IYGARAAAGVILVTTKRGKT---GEPTVTYDGYVAMQSMTTTPNYMNSLQYMEAVNRGFTAQGGNEFYTEQHFeTVRNGG 294
Cdd:cd01347     92 LYGSGAIGGVVNIITKRPTDefgGSVTAGYGSDNSGSSGGGGFDVSGALADDGAFGARLYGAYRDGDGTIDGD-GQADDS 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  295 DH----LMGQFDWWdavyrdnaPQQSHYVNVTGGTEKTKYLASVGYMDQQGFYQTENYFKRYNTRLNITTELSKRlkaTA 370
Cdd:cd01347    171 DEerynVAGKLDWR--------PDDDTRLTLDAGYQDQDADGPGGTLPANGTGSSLGGGPSSNTNGDRDWDYRDR---YR 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  371 QMNFTRQEQQDTGDSWRATQALAmvplnpiYNQ-DGTYNITRPVDNTRFENTLAHMKLSDYIRKVNQlqsflsldyeiak 449
Cdd:cd01347    240 KRASLGLEHDLNDTGWTLRANLS-------YSYtDNDGDPLILNGGNNAAGGDLGRSGYSSERDTTQ------------- 299

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1042791390  450 nLTVTGRTSMNFRSFEQNH-FQQGYQFVHSHNNAvglNLQSAAAED 494
Cdd:cd01347    300 -LGFDAGLNAPFGTGPVAHtLTLGVEYRREELDE---KQTALYAQD 341
PRK13484 PRK13484
IreA family TonB-dependent siderophore receptor;
80-250 2.28e-05

IreA family TonB-dependent siderophore receptor;


Pssm-ID: 139605 [Multi-domain]  Cd Length: 682  Bit Score: 48.46  E-value: 2.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390   80 FVGYLSQTIAIGTRSVIDVVLEADAEQLEEVIVVGYG-TQEKVNVTGSVAQVDSEVLSAVPTPDAIGALQGrIAGVTVNp 158
Cdd:PRK13484     3 NKYIIAPGIAVMCSAVISSGYASSDKKEDTLVVTASGfTQQLRNAPASVSVITSEQLQKKPVSDLVDAVKD-VEGISIT- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  159 gqGPGATPTIRVRGvtsMSGSNDpLIVIDGI-PSTVEN-----------FATLANSdIETISVLKDAASaSIYGARAAAG 226
Cdd:PRK13484    81 --GGNEKPDISIRG---LSGDYT-LILVDGRrQSGRESrpngsggfeagFIPPVEA-IERIEVIRGPMS-SLYGSDAIGG 152

                          170       180
                   ....*....|....*....|....*.
gi 1042791390  227 VILVTTKrgktgePTV--TYDGYVAM 250
Cdd:PRK13484   153 VINIITK------PVNnqTWDGVLGL 172
 
Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 29-1035 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 887.71  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390   29 RTITGTIHDENNEPLIGANILIEGTTNGTIADFDGKYHLEVPEGtNNIVVSFVGYLSQTIAIGTRSVIDVVLEADAEQLE 108
Cdd:TIGR04056    1 ITVTGVVVDETGEPLIGASVVVKGTTNGTITDIDGNFSLKVPPG-AVLVFSYIGYKTQEVKVKGQKNLNITLKEDTQELD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  109 EVIVVGYGTQEKVNVTGSVAQVDSEVLSAVPTPDAIGALQGRIAGVTVNPGQG-PGATPTIRVRGVTSMSGSNDPLIVID 187
Cdd:TIGR04056   80 EVVVVGYGTQKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGePGGDAEIWIRGISSFGGNNSPLYVID 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  188 GIPSTvENFATLANSDIETISVLKDAASASIYGARAAAGVILVTTKRGKTGEPTVTYDGYVAMQSMTTTPNYMNSLQYME 267
Cdd:TIGR04056  160 GVPRD-NGLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGKEGKPKISYNAEFGFSTPTRLPEMLNAYEYAE 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  268 AVNRGFTAQG--GNEFYTEQHFETVRNGGD-HLMGQFDWWDAVYRDNAPQQSHYVNVTGGTEKTKYLASVGYMDQQGFYQ 344
Cdd:TIGR04056  239 LYNEALLNRGssPPDIYTDEEIEAYRNGLDpDLYPNTDWQDEIFKRTAFNQRHNLSVSGGTEKARYYVSLGYYNEEGILK 318

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  345 TENYfKRYNTRLNITTELSKRLKATAQMNFTRQEQQ----DTGDSWRAtqALAMVPLNPI----YNQDGTYNITRPVDNT 416
Cdd:TIGR04056  319 NSDY-KRYNFRANIDAKLTKTLKLSLNVSGSLSKYNnpggSTSNIWGA--LMLFPRGTPYstppVYSDGYYPAYNSGNTS 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  417 RFeNTLAHMKLSDYIRKVNQLQSFLSLDYEIAKNLTVTGRTSMNFRSFEQNHfqqgYQFVHSHNNAVGLNLQSAAAEDWN 496
Cdd:TIGR04056  396 LQ-NPYALLNRGYNENERNRLNGNASLEQKITKGLKLKGTFSYDYSNYKNKK----YYKNPYYYNATGGANNGYYSESNS 470

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  497 NSMRVVNDLVMNYHVDFGKHHIGALVGIAEEFFRYDRLYGRRVNFANnqlrkiIAGGQAGQIAESNAYDWALQSQFARIN 576
Cdd:TIGR04056  471 RSRNYYLEATLNYNRTFGKHNVSALLGYSQQENKSSSYGGLLDDLPS------LDAGTSDASVSGSDSEYRLQSLFGRAT 544

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  577 YDYDKKYLLEVNVRRDVSSRFHKDNRAGVFPSVSVGWRIAEEDFFKDNvsENFISDIKFRGSVGSLGNQNINNsavsnlY 656
Cdd:TIGR04056  545 YSYKDRYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEEKFMKKL--KKWLSFLKLRASYGIVGNDNIGD------R 616

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  657 YPYMGVISAADYPYNNELVMGK-----AQNEMPVPGLKWETTVTYNAGIDIDFLDGKLGTSFDYFKKITSDMLLPLPMSA 731
Cdd:TIGR04056  617 YPYLSLYNLGDGGYNFGTNNGTsvtgiTESRYGNPNLKWEKTKKWNLGLDLGFFNNRLSLTVDYYYKKTKDILQSRSLPS 696

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  732 VGGLGNPWENAATLENTGWEFDIRYSNTTKSGFTYGIGANISHFTNVLTDLAGG---FSEYSNQFREGDPIGTIYGYRTK 808
Cdd:TIGR04056  697 VTGYSSPYANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILELDEGaylPVKYPYISKEGGPIGQIYGYIAD 776

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  809 GIYRDQAHVDADNAkladaslkngvaqtrNVMLGDLIYEDINGDGIINHEDMVAIGNT-LPKYQFGITFDFAYKNFDLSM 887
Cdd:TIGR04056  777 GLFKDDDSPKQTFG---------------NVRPGDIKYKDVNGDGKIDDDDRVPIGYSnTPDLTYGFGNSFSYKGFDLSA 841

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  888 FWQGAAD----IDGYVGYNVFAGNKDSNLRDFYTDAYHPDlNPNGAYPRFSPDE--NSQNHEVNDFWVQSASYLRLKNLQ 961
Cdd:TIGR04056  842 LFQGSGGgdvfNDGRGFYPFNGGDWGNVLKIVADNRWTPE-NPNADYPRLSYGDsnNSNNYQASTRWLEDGSYLRLKNLT 920

                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1042791390  962 IGYSLPKTVTDQMKIGKARVYLSGQNLLTITNFDeGFDPEMVApmnqdgsfqvgdVRPSFMPTVRVVSAGLQVT 1035
Cdd:TIGR04056  921 LGYTLPKKWLKKIGISNLRVYFSGQNLFTFSKYK-GWDPELQG------------NDGGAYPLQRTFSFGVNLT 981
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
107-805 1.26e-45

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 175.02  E-value: 1.26e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  107 LEEVIVVGYGTQEKV-NVTGSVAQVDSEVLSAVPTPDAIGALQgRIAGVTVNPGQGPGATPTIRvrGVTSmsGSNDPLIV 185
Cdd:COG1629      1 LEEVVVTATRTDESLqDVPGSVSVISREQLEDQPATDLGDLLR-RVPGVSVTSAGGGAGQISIR--GFGG--GGNRVLVL 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  186 IDGIPST-----VENFATLANSDIETISVLKDAASAsIYGARAAAGVILVTTKRGKTGeptvtydgyvamqsmtttpnym 260
Cdd:COG1629     76 VDGVPLNdpsggDGGLSYIDPEDIERVEVLRGPSSA-LYGSGALGGVINIVTKKPKDG---------------------- 132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  261 nslqymeavnRGFTAQGGnefyteqhfetvrnggdhlMGQFDWwdavyrdnapqQSHYVNVTGGTEKTKYLASVGYMDQQ 340
Cdd:COG1629    133 ----------KGGEVSAS-------------------YGSYGT-----------YRASLSLSGGNGKLAYRLSASYRDSD 172

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  341 GFYQTENYfKRYNTRLNITTELSKRLKATAQMNFTRQEQQDTGDSWRATqalamvpLNPIYNQDGTYNitrpvdntrfen 420
Cdd:COG1629    173 GYRDNSDS-DRYNLRAKLGYQLGDDTRLTLSASYSDSDQDSPGYLTLAA-------LRPRGAMDDGTN------------ 232

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  421 tlahmKLSDYIRKVNQLQSFLSLDYE-IAKNLTVTGRTSmnFRSFEQNHFQQGYQFVHSHNNavglnlqsaAAEDWNNSM 499
Cdd:COG1629    233 -----PYSNDTDDNTRDRYSLSLEYEhLGDGLKLSASAY--YRYDDTDLDSDFTPTPADGGT---------LEQTDFDNR 296

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  500 RVVNDLVMNYHVDFGKHHIGaLVGIaeEFFRYDrlyGRRVNFANNQLRKIIAGGQAGQIAESNAYDWALqsqFARINYDY 579
Cdd:COG1629    297 TYGLELRLTYDLGFGGKHTL-LVGL--DYQRQD---LDGSGYPLDLGSGSLPTLTSGADDDGTTTSLAL---YAQDTYKL 367

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  580 DKKYLLEVNVRRDVSSRFHKDNRAG------------VFPSVSVGWRIAEEDFFKDNVSENFISdikfrGSVGSLGNQNI 647
Cdd:COG1629    368 TDKLTLTAGLRYDYVSYDVDDTVTGtdsasgsrsysaFSPSLGLTYQLSPNLSLYASYSRGFRA-----PTFGELYANGT 442

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  648 NNSAVSNlyypymgvisaadypynnelvmgkaqnempvPGLKWETTVTYNAGIDIDFLDGKLGTSFDYFKKITSDMLLPL 727
Cdd:COG1629    443 DPYSVGN-------------------------------PDLKPETSTNYELGLRYRLLDGRLSLSLALFYSDVDNEILSV 491

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1042791390  728 PMSAVGGLGNPWENAATLENTGWEFDIRYSNTtkSGFTygIGANISHFTNVLTDLAGGFSEYSNQFREGDPIGTIYGY 805
Cdd:COG1629    492 PLPNDSGFSTYYTNAGKARSYGVELELSYQLT--PGLS--LNASYSYTDAKFDDDTDGSADLDGNRLPGVPPLTANLG 565
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 97-756 2.75e-38

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 152.32  E-value: 2.75e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390   97 DVVLEADAEQLEEVIVVGYGTQEKV-NVTGSVAQVDSEVLSAVPTPDAIGALQgRIAGVTVNPGQGPGATPTIRVRGVts 175
Cdd:COG4771     17 ADALAEDATELEEVVVTATRTEQSLsDAPASVSVITAEEIEKLGATDLADALR-LLPGVSVTRSGGRGGSSGISIRGL-- 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  176 msGSNDPLIVIDGIP------STVENFATLANSDIETISVLKDAASAsIYGARAAAGVILVTTKRG-KTGEPTVTYDGYV 248
Cdd:COG4771     94 --GGDRVLVLIDGVPvnnpalGGGGDLSYIPPDDIERIEVIRGPASA-LYGSDAIGGVINIITKKPtDELEGSVSLGYGS 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  249 amqsmtttpnymnslqymeavnrgftaqggnefyteqhfetvrnggdhlmgqfdwwdavyrDNAPQQSHYVNVTGGTEKT 328
Cdd:COG4771    171 -------------------------------------------------------------NGNGTYSGSLSLGGPGDKL 189

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  329 KYLASVGYMDQQGFY-------QTENYFKRYNTRLNITTELSKRLKATAQMNFTRQEQQDTGDswratqalamvplnPIY 401
Cdd:COG4771    190 SFLLSGSYRDRDGYLdyrnggfVGNSGYERYNLNAKLGYRLSDNHRLSLSGGYSRQDRDGGPP--------------TLG 255

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  402 NQDGTYNITRPVDNTRFENTLAhmklsdyirkvnqlqsfLSLDYEIAKNLTVT-GRTSMNFRSFEQNHFQQGYQFVHSHN 480
Cdd:COG4771    256 DTEISSDNAGDRDTTTDRGNYS-----------------LRYNGDLGDNLDLSlYYSRTDRDSTNGSLGGSTGSFSDSDD 318

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  481 NAVGLNLQsaaaedwnnsmrvvndlvmnYHVDFGKHHIgALVGIAeefFRYDRLYGRRVNFANNQLRKIIAGgqagqiae 560
Cdd:COG4771    319 TTYGLELD--------------------LTYPLGGNHT-LTLGAE---YRYDDLDSSSFLGGADASRDTYGL-------- 366

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  561 snaydwalqsqFARINYDYDKKYLLEVNVRRDVSSRFHKDNRAGVFPSVSVGWRIAEedffkdnvsenfisDIKFRGSVG 640
Cdd:COG4771    367 -----------FAQDEWKLTDKLTLTAGLRYDYYSTFGASNYTAFSPRLGLRYDLSD--------------NLTLRASYG 421

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  641 SlGNQNINNSAVSNLYYPYMGVISAADypynnelvmgkaqnempvPGLKWETTVTYNAGIDIDFLDGKLGTSFDYFKKIT 720
Cdd:COG4771    422 R-GFRAPSLAELYGSGTGTPGRYVLGN------------------PDLKPETSDNYELGLEYRLGNGGLSLSLTGFYTDI 482

                          650       660       670
                   ....*....|....*....|....*....|....*.
gi 1042791390  721 SDMLLPLPMSAVGGLGNPWENAATLENTGWEFDIRY 756
Cdd:COG4771    483 KDLIVLVPVGPGPGDVLQYENVGKARTYGLELELKY 518
BtuB COG4206
Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];
110-385 8.56e-31

Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];


Pssm-ID: 443355 [Multi-domain]  Cd Length: 276  Bit Score: 122.67  E-value: 8.56e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  110 VIVVGYG-TQEKVNVTGSVAQVDSEVLSAVPTPDAIGALQgRIAGVTVNPGQGPGATPTIRVRGVtsmsGSNDPLIVIDG 188
Cdd:COG4206      1 VVVTATRlEQSKSDLTGSVTVIDAEELERSGATSLADALR-RVPGVQVSSSGGPGSAASISIRGL----GSNQTLVLIDG 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  189 IP-----STVENFATLANSDIETISVLKDAASAsIYGARAAAGVILVTTKRGKTG-EPTVTYdgyvamqSMTTTPNYMNS 262
Cdd:COG4206     76 VPlndpsLGGVDLSLIPPDDIERIEVLKGAASA-LYGSDAIGGVINITTKKGKKGfKGSVSA-------SYGSFGTRRLS 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  263 LQYMEAVNRGFTAQGGNEFYTEqhfetvrnggdhlmgQFDWWDAVYRDNAPQQSHYVNVTGG---TEKTKYLASVGYMD- 338
Cdd:COG4206    148 ASLSGGAGKFSYSLSASYRRSD---------------GYRYNDPDLRNNDGYENTSLNARLGyklGDNGSLSLSGGYSDs 212

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1042791390  339 QQGFYQTENYFKRYNTRLNITTELSKRLKATAQMNFTRQEQQDTGDS 385
Cdd:COG4206    213 ERGYPGAVGSDRNLRLSLSLEYKLSDGWSLLLLAYYYYDRDYEDGGG 259
CarbopepD_reg_2 pfam13715
CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, ...
 31-112 2.02e-20

CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.


Pssm-ID: 433425 [Multi-domain]  Cd Length: 88  Bit Score: 86.49  E-value: 2.02e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390   31 ITGTIHDEN-NEPLIGANILIEGTTNGTIADFDGKYHLE-VPEGTNNIVVSFVGY--LSQTIAIGTRSVIDV--VLEADA 104
Cdd:pfam13715    1 ISGTVVDENtGEPLPGATVYVKGTTKGTVTDADGNFELKnLPAGTYTLVVSFVGYktQEKKVTVSNDNTLDVnfLLKEDA 80


                   ....*...
gi 1042791390  105 EQLEEVIV 112
Cdd:pfam13715   81 LLLDEVVV 88
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 119-227 4.30e-16

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 75.00  E-value: 4.30e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  119 EKVNVTGSVAQVDSEVLSAVPTPDAIGALQgRIAGVTVNpGQGPGATPTIRVRGVtsmsGSNDPLIVIDGIP-----STV 193
Cdd:pfam07715    1 DLRDTPGSVSVVTAEDIEDQGATNLADALR-GVPGVSVS-SGGGGGGSSISIRGF----GSNRVLVLVDGVPlnsggGGS 74

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1042791390  194 ENFATLANSDIETISVLKDAASAsIYGARAAAGV 227
Cdd:pfam07715   75 VDLNSIDPEDIERVEVLKGPASA-LYGSGAIGGV 107
SusC_RagA_signa TIGR04057
TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; This model ...
 203-233 8.18e-12

TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; This model describes a 31-residue signature region of the SusC/RagA family of outer membrane proteins from the Bacteriodetes. While many TonB-dependent outer membrane receptors are associated with siderophore import, this family seems to include generalized nutrient receptors that may convey fairly large oligomers of protein or carbohydrate. This family occurs in high copy numbers in the most abundant species of the human gut microbiome.


Pssm-ID: 274949 [Multi-domain]  Cd Length: 31  Bit Score: 60.29  E-value: 8.18e-12
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1042791390  203 DIETISVLKDAASASIYGARAAAGVILVTTK 233
Cdd:TIGR04057    1 DIESISVLKDASAAAIYGSRGANGVILITTK 31
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 144-494 1.06e-10

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 65.55  E-value: 1.06e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  144 IGALQGRIAGVTVNPGQGPGATpTIRVRGVtsmsGSNDPLIVIDGIPSTVENFATLANSD------IETISVLKDAASAs 217
Cdd:cd01347     18 LADLLRRIPGVSVTRGGGGGGS-TISIRGF----GPDRTLVLVDGLPLASSNYGRGVDLNtippelIERVEVLKGPSSA- 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  218 IYGARAAAGVILVTTKRGKT---GEPTVTYDGYVAMQSMTTTPNYMNSLQYMEAVNRGFTAQGGNEFYTEQHFeTVRNGG 294
Cdd:cd01347     92 LYGSGAIGGVVNIITKRPTDefgGSVTAGYGSDNSGSSGGGGFDVSGALADDGAFGARLYGAYRDGDGTIDGD-GQADDS 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  295 DH----LMGQFDWWdavyrdnaPQQSHYVNVTGGTEKTKYLASVGYMDQQGFYQTENYFKRYNTRLNITTELSKRlkaTA 370
Cdd:cd01347    171 DEerynVAGKLDWR--------PDDDTRLTLDAGYQDQDADGPGGTLPANGTGSSLGGGPSSNTNGDRDWDYRDR---YR 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  371 QMNFTRQEQQDTGDSWRATQALAmvplnpiYNQ-DGTYNITRPVDNTRFENTLAHMKLSDYIRKVNQlqsflsldyeiak 449
Cdd:cd01347    240 KRASLGLEHDLNDTGWTLRANLS-------YSYtDNDGDPLILNGGNNAAGGDLGRSGYSSERDTTQ------------- 299

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1042791390  450 nLTVTGRTSMNFRSFEQNH-FQQGYQFVHSHNNAvglNLQSAAAED 494
Cdd:cd01347    300 -LGFDAGLNAPFGTGPVAHtLTLGVEYRREELDE---KQTALYAQD 341
CarboxypepD_reg pfam13620
Carboxypeptidase regulatory-like domain;
30-100 5.05e-10

Carboxypeptidase regulatory-like domain;


Pssm-ID: 433354 [Multi-domain]  Cd Length: 81  Bit Score: 56.90  E-value: 5.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390   30 TITGTIHDENNEPLIGANILIE----GTTNGTIADFDGKYHLE-VPEGTNNIVVSFVGYLSQ-----TIAIGTRSVIDVV 99
Cdd:pfam13620    1 TISGTVTDPSGAPVPGATVTVTntdtGTVRTTTTDADGRYRFPgLPPGTYTVTVSAPGFKTAtrtgvTVTAGQTTTLDVT 80


                   .
gi 1042791390  100 L 100
Cdd:pfam13620   81 L 81
TonB_dep_Rec pfam00593
TonB dependent receptor; This model now only covers the conserved part of the barrel structure.
 428-766 1.06e-08

TonB dependent receptor; This model now only covers the conserved part of the barrel structure.


Pssm-ID: 395474 [Multi-domain]  Cd Length: 475  Bit Score: 59.01  E-value: 1.06e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  428 SDYIRKVNQLQSFLSLDYEIAKNLTVTGRTSMNFRsfeqnhfqqgYQFVHSHNNAVGLNLQSAAAEDWNNSMRVVNDLVM 507
Cdd:pfam00593   52 GRDYSDTDRKRLSLGYDYDLGDGLSWLSTLRLGLR----------YSSLDGDYTSNSSGLSGAGDYLSDDRLYGLYGLDG 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  508 NYHVDFGKHHiGALVGIAEEFFRYDrlYGRRVNFANNQLRKIIAGGQAGQIAESNAYdwalqSQFARINYDYDKKYLLEV 587
Cdd:pfam00593  122 DLELSLDLSH-DLLLGVELRTAGLD--YRRLDDDAYDPYDPANPSSSSYSDTTTDSY-----GLYLQDNIKLTDRLTLTL 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  588 NVRRDVSSRFHKDNRAG----------VFPSVSVGWRIAEedffkdnvsenfisDIKFRGSVGslgnQNINNSAVSNLYY 657
Cdd:pfam00593  194 GLRYDHYSTDGDDGNGGgdnfsrsysaFSPRLGLVYKPTD--------------NLSLYASYS----RGFRAPSLGELYG 255

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  658 PYMGVISAADYPYNnelvmgkaqnempvPGLKWETTVTYNAGidIDFLDGKLGTSFDYFKKITSDMLLPLP-MSAVGGLG 736
Cdd:pfam00593  256 SGSGGGGGAVAGGN--------------PDLKPETSDNYELG--LKYDDGRLSLSLALFYIDIKNLITSDPdGPGLGGTV 319

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1042791390  737 NPWENAATLENTGWEFDIRYS----NTTKSGFTY 766
Cdd:pfam00593  320 YTYTNVGKARIRGVELELSGRlwglGLSGGGYTY 353
FecA COG4772
Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];
101-629 9.89e-08

Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];


Pssm-ID: 443804 [Multi-domain]  Cd Length: 681  Bit Score: 56.09  E-value: 9.89e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  101 EADAEQLEEVIVVGYGTQEKV--NVTGSVAQVDSEVLSAVPTPDAIGALQgRIAGVTVNPGQGPGATPTIRVRGVTS--M 176
Cdd:COG4772     17 AEAATTLETVVVTGSRAAEARlkDVPGSVSVVDREELENQAATSLREVLR-RVPGVNVQEEDGFGLRPNIGIRGLGPrrS 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  177 SGSNdplIVIDGIPSTV--------ENFATLANsdIETISVLKDAASAsIYGARAAAGVILVTTKRGKTgeptvtydgyv 248
Cdd:COG4772     96 RGIT---LLEDGIPIAPapygdpaaYYFPDLER--MERIEVLRGAAAL-RYGPQTVGGAINFVTRTIPT----------- 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  249 amqsmtttpnymnslqymeavnrGFTAQGGNEFyteqhfetvrnggdhlmGQFDWWDAvyrdnapqqshYVNVTGGTEKT 328
Cdd:COG4772    159 -----------------------AFGGELRVTG-----------------GSFGYRRT-----------HASVGGTVGNF 187

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  329 KYLASVGYMDQQGFyQTENYFKRYNTRLNITTELSKRLKATAQMNFTRQEQQDTGDSwraTQALamvplnpiYNQDGTYN 408
Cdd:COG4772    188 GYLVEYSRKRGDGF-RDNSGFDINDFNAKLGYRLSDRQELTLKFQYYDEDANTPGGL---TDAQ--------FDADPRQS 255

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  409 iTRPVDNtrfentlahmklsdyiRKVNQLQSFLSLDYEIAKNLTVtgrTSMNFRSfeQNHFQQGYQFVHSHNNAVGLNLQ 488
Cdd:COG4772    256 -YRPADQ----------------FDTRRTQLSLRYEHQLSDNTTL---TTTAYYN--DFSRNWYIRQNTADPNTPGLGLR 313

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  489 SAAAEDWNNSMrvvnDLVMNYHVDFGKHHIGALVGiaeefFRYDRLYGRRVNFANNQLRKII-AGGQAGQIAESNAYDWA 567
Cdd:COG4772    314 GNPRGYRSYGI----EPRLTHRFELGGVPHTLEVG-----LRYHREEEDRKQYVNTYGQGRSgAGLRRDRRFSADALAAY 384

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1042791390  568 LQSQFA--------------RINYDYDKKYLLEVNVRRDVSSRFHKdnragVFPSVSVGWRIAEEDFFKDNVSENF 629
Cdd:COG4772    385 AQNRFEltgrltltpglryeHIRRDRTDRYSTRTGGDDSGSNSYSE-----FLPGLGLLYQLTDNLQLYANVSRGF 455
TonB-siderophor TIGR01783
TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of ...
 122-254 9.81e-06

TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273805 [Multi-domain]  Cd Length: 651  Bit Score: 49.72  E-value: 9.81e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  122 NVTGSVAQVDSEVLSAVPTPDAIGALQgRIAGVTVNPGQGPGATPTIRVRGVTSMSGSNDplIVIDGIPSTVE-NFATLA 200
Cdd:TIGR01783    1 DIPQSVSVITRQELEDQQAGSLSEALQ-RVPGVVVGGSGGTTQFGNITIRGFGLEVDIDN--VYLDGVPLLSRgNLAIVD 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1042791390  201 NSDIETISVLKDAASAsIYGARAAAGVILVTTKRGkTGEPTvtydGYVAMQSMT 254
Cdd:TIGR01783   78 PAMVERVEVLRGPASL-LYGGSAPGGVINIVTKRP-QDEPK----GSVTFGAGT 125
PRK13484 PRK13484
IreA family TonB-dependent siderophore receptor;
80-250 2.28e-05

IreA family TonB-dependent siderophore receptor;


Pssm-ID: 139605 [Multi-domain]  Cd Length: 682  Bit Score: 48.46  E-value: 2.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390   80 FVGYLSQTIAIGTRSVIDVVLEADAEQLEEVIVVGYG-TQEKVNVTGSVAQVDSEVLSAVPTPDAIGALQGrIAGVTVNp 158
Cdd:PRK13484     3 NKYIIAPGIAVMCSAVISSGYASSDKKEDTLVVTASGfTQQLRNAPASVSVITSEQLQKKPVSDLVDAVKD-VEGISIT- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  159 gqGPGATPTIRVRGvtsMSGSNDpLIVIDGI-PSTVEN-----------FATLANSdIETISVLKDAASaSIYGARAAAG 226
Cdd:PRK13484    81 --GGNEKPDISIRG---LSGDYT-LILVDGRrQSGRESrpngsggfeagFIPPVEA-IERIEVIRGPMS-SLYGSDAIGG 152

                          170       180
                   ....*....|....*....|....*.
gi 1042791390  227 VILVTTKrgktgePTV--TYDGYVAM 250
Cdd:PRK13484   153 VINIITK------PVNnqTWDGVLGL 172
Fiu COG4774
Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];
152-543 3.52e-05

Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];


Pssm-ID: 443806 [Multi-domain]  Cd Length: 639  Bit Score: 47.95  E-value: 3.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  152 AGVTVNPGQGpGATPTIRVRGvtsMSGSNDplIVIDGIPSTVENFATLANsdIETISVLKDAASAsIYGARAAAGVILVT 231
Cdd:COG4774     37 PGVTFGAGEG-GNGDSFSIRG---FSASGD--IYVDGLRDPGQYRRDTFN--LERVEVLKGPASV-LYGRGSPGGVINLV 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  232 TKRgktgePTvtydgyvamqsmtttpnymnslqyMEAVNRgFTAQGGNefyteqhfetvrngGDHLMGQFDwwdavyrdn 311
Cdd:COG4774    108 TKR-----PT------------------------DEPFTE-VTLTYGS--------------DGQRRATLD--------- 134

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  312 apqqshyvnVTGG-TEKTKYLASVGYMDQQGFYQtENYFKRYNTRLNITTELSKRLKATAQMNFTRQEQQ-DTGDSWRAT 389
Cdd:COG4774    135 ---------VNGPlGDDLAYRLNGMYRDSDSYRD-GVDNDRWGIAPSLTWRLGDRTRLTLDYEYQDDDRTpDYGVPAVAN 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  390 QALAMVPLNPIYNQDGTYNitrpvdntrfentlahmklsdyirKVNQLQSFLSLDYEIAKNLTVTGRTSMnfrsfeqNHF 469
Cdd:COG4774    205 GRPVDVDRSTFYGQPDDYS------------------------DSETDSATLRLEHDFNDNWTLRNALRY-------SDY 253

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1042791390  470 QQGYQFVHSHNNAVGLNLQSAAAEDWNNSMRVVNDLVMNYHVDFG--KHHIgaLVGIaeEFFRYDRLYGRRVNFAN 543
Cdd:COG4774    254 DRDYRNTYPTGGNATGTVTRSAYRRDQDNDTLSNQTDLTGKFDTGgvKHTL--LAGV--EYSREDSDNARYSGGGT 325
FhuE COG4773
Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion ...
 76-234 5.49e-04

Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism];


Pssm-ID: 443805 [Multi-domain]  Cd Length: 692  Bit Score: 44.12  E-value: 5.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390   76 IVVSFVGYLSQTIAIGTrsviDVVLEADAEQLEEVIVVG-------YGTQEKVNVTG----------SVAQVDSEVLsav 138
Cdd:COG4773      5 LAGSGLAAAAAGALAQA----AAAAAAEATTLPEVTVTGtaegtggYTAKSSSTATKldtplretpqSVSVVTRQLI--- 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  139 ptpDAIGALQ-----GRIAGVTVNPGQGPGATpTIRVRGvtsMSGSNdplIVIDGIPSTVENFATLANSDIETISVLKDA 213
Cdd:COG4773     78 ---EDQGATTlddalRNVPGVTVSSYDGGGRD-SFSIRG---FSIDN---YLRDGLPLGGFGGGQPDTANLERVEVLKGP 147

                          170       180
                   ....*....|....*....|.
gi 1042791390  214 ASAsIYGARAAAGVILVTTKR 234
Cdd:COG4773    148 AGL-LYGAGSPGGLVNLVTKR 167
PRK13513 PRK13513
ligand-gated channel protein;
78-238 1.02e-03

ligand-gated channel protein;


Pssm-ID: 184104 [Multi-domain]  Cd Length: 659  Bit Score: 43.22  E-value: 1.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390   78 VSFVGYLSQTIAIGTRSVIDV-----VLEADAEQLEEVIVVGYGTQEKV-NVTGSVAQVDSEVLSAVPTPDAIGALQGrI 151
Cdd:PRK13513     1 VNQRFRKTHKAALVIAAAISSqayaaEKTNTATPTDTMVVTASGFQQRIqDAPASISVVTREQLENKAYRDVTDALKD-V 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  152 AGVTVNPGqgpGATPTIRVRGvtsMSgSNDPLIVIDGipSTVENFATLANSD--------------IETISVLKDAASaS 217
Cdd:PRK13513    80 PGVVVTGG---GSTSDISIRG---MA-AKYTLILVDG--KRVDTRSTRPNSDgsgieqgwlpplaaIERIEVVRGPMS-S 149

                          170       180
                   ....*....|....*....|.
gi 1042791390  218 IYGARAAAGVILVTTKRGKTG 238
Cdd:PRK13513   150 LYGSDAMGGVINIITRKVQKE 170
PRK13483 PRK13483
ligand-gated channel protein;
101-234 1.17e-03

ligand-gated channel protein;


Pssm-ID: 184080 [Multi-domain]  Cd Length: 660  Bit Score: 42.84  E-value: 1.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  101 EADAEQLEEVIVVGYG-TQEKVNVTGSVAQVDSEVLSAVPTPDAIGALQgRIAGVTVNPGqgpGATPTIRVRGVtsmsGS 179
Cdd:PRK13483    27 AAPDKTMETVVVTASGyEQQIRDAPASISVITREDLENRFYRDLTDALL-DVPGVVVTGG---GDRTDISLRGM----GS 98

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  180 NDPLIVIDGI-PSTVEnfaTLANSD--------------IETISVLKDAASaSIYGARAAAGVILVTTKR 234
Cdd:PRK13483    99 QYTLILVDGKrQSSRE---TRPNSDgpgveqawtpplaaIERIEVIRGPMS-SLYGSDAIGGVINIITRK 164
PRK13486 PRK13486
TonB-dependent receptor;
108-234 3.56e-03

TonB-dependent receptor;


Pssm-ID: 139606 [Multi-domain]  Cd Length: 696  Bit Score: 41.16  E-value: 3.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042791390  108 EEVIVVGYGTQEK--VNVTGSVAQVDSEVLSAVPTPDAIGALQGrIAGVTVNPGQGPGATPTIRVRGvtsMSGSNDpLIV 185
Cdd:PRK13486    25 EDVMIVSASGYEKklTNAAASVSVISQEELQSSQYHDLAEALRS-VEGVDVESGTGKTGGLEISIRG---MPASYT-LIL 99

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1042791390  186 IDGIPS------TVENFATLAN------SDIETISVLKDAASaSIYGARAAAGVILVTTKR 234
Cdd:PRK13486   100 IDGVRQggssdvTPNGFSAMNTgfmpplAAIERIEVIRGPMS-TLYGSDAMGGVVNIITRK 159
Peptidase_M14NE-CP-C_like cd11308
Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, ...
 31-87 9.87e-03

Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; This domain is found C-terminal to the M14 carboxypeptidase (CP) N/E subfamily containing zinc-binding enzymes that hydrolyze single C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. The N/E subfamily includes enzymatically active members (carboxypeptidase N, E, M, D, and Z), as well as non-active members (carboxypeptidase-like protein 1, -2, aortic CP-like protein, and adipocyte enhancer binding protein-1) which lack the critical active site and substrate-binding residues considered necessary for activity. The active N/E enzymes fulfill a variety of cellular functions, including prohormone processing, regulation of peptide hormone activity, alteration of protein-protein or protein-cell interactions and transcriptional regulation. For M14 CPs, it has been suggested that this domain may assist in folding of the CP domain, regulate enzyme activity, or be involved in interactions with other proteins or with membranes; for carboxypeptidase M, it may interact with the bradykinin 1 receptor at the cell surface. This domain may also be found in other peptidase families.


Pssm-ID: 200604 [Multi-domain]  Cd Length: 76  Bit Score: 35.96  E-value: 9.87e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1042791390   31 ITGTIHDENNEPLIGANILIEGTTNGTIADFDGKYHLEVPEGTNNIVVSFVGYLSQT 87
Cdd:cd11308      2 IKGFVTDATGNPIANATISVEGINHDVTTAKDGDYWRLLLPGTYNVTASAPGYQPVT 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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