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Conserved domains on  [gi|1042779809|ref|NP_001316155|]
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low-density lipoprotein receptor-related protein 10 isoform 2 precursor [Homo sapiens]

Protein Classification

CUB and LDLa domain-containing protein( domain architecture ID 10035864)

CUB and LDLa (low-density lipoprotein receptor class A) domain-containing protein similar to Homo sapiens low-density lipoprotein receptor-related protein 12 which may be involved in the internalization of lipophilic molecules and/or signal transduction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 399-433 2.68e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.37  E-value: 2.68e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1042779809 399 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 192-302 4.28e-11

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 60.12  E-value: 4.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042779809 192 CNVTL-EDFYGVFSSPGYTHlaSVSHPQSCHWLLDPHDGRRLAVRFTALDLGFG-----DAVHVYDGPGppESSRLLRSL 265
Cdd:cd00041     1 CGGTLtASTSGTISSPNYPN--NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPS--TSSPLLGRF 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1042779809 266 THFSNGKavTVETLSGQAVVSYHTVAWSNGRGFNATY 302
Cdd:cd00041    77 CGSTLPP--PIISSGNSLTVRFRSDSSVTGRGFKATY 111
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 140-174 5.70e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.52  E-value: 5.70e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1042779809 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 34-134 6.86e-07

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 48.18  E-value: 6.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042779809  34 VLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHL----ACGSERLTLR----SPLQPLISLC-EAPPSP 104
Cdd:cd00041     5 LTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLesspNCSYDYLEIYdgpsTSSPLLGRFCgSTLPPP 84

                          90       100       110
                  ....*....|....*....|....*....|
gi 1042779809 105 LQLPGGNVTITYSYAGARApmGQGFLLSYS 134
Cdd:cd00041    85 IISSGNSLTVRFRSDSSVT--GRGFKATYS 112
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 330-353 2.74e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 38.34  E-value: 2.74e-04
                          10        20
                  ....*....|....*....|....
gi 1042779809 330 RCYSEAQRCDGSWDCADGTDEEDC 353
Cdd:cd00112    12 RCIPSSWVCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 399-433 2.68e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.37  E-value: 2.68e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1042779809 399 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 192-302 4.28e-11

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 60.12  E-value: 4.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042779809 192 CNVTL-EDFYGVFSSPGYTHlaSVSHPQSCHWLLDPHDGRRLAVRFTALDLGFG-----DAVHVYDGPGppESSRLLRSL 265
Cdd:cd00041     1 CGGTLtASTSGTISSPNYPN--NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPS--TSSPLLGRF 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1042779809 266 THFSNGKavTVETLSGQAVVSYHTVAWSNGRGFNATY 302
Cdd:cd00041    77 CGSTLPP--PIISSGNSLTVRFRSDSSVTGRGFKATY 111
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 140-174 5.70e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.52  E-value: 5.70e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1042779809 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 399-430 8.98e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.79  E-value: 8.98e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1042779809  399 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
399-433 3.76e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.25  E-value: 3.76e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1042779809 399 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 140-171 2.62e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.55  E-value: 2.62e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1042779809  140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDE 171
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 34-134 6.86e-07

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 48.18  E-value: 6.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042779809  34 VLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHL----ACGSERLTLR----SPLQPLISLC-EAPPSP 104
Cdd:cd00041     5 LTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLesspNCSYDYLEIYdgpsTSSPLLGRFCgSTLPPP 84

                          90       100       110
                  ....*....|....*....|....*....|
gi 1042779809 105 LQLPGGNVTITYSYAGARApmGQGFLLSYS 134
Cdd:cd00041    85 IISSGNSLTVRFRSDSSVT--GRGFKATYS 112
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 201-302 9.96e-07

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 47.38  E-value: 9.96e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042779809  201 GVFSSPGYthLASVSHPQSCHWLLDPHDGRRLAVRFTALDL-----GFGDAVHVYDGPGppESSRLLRSLTHfSNGKAVT 275
Cdd:smart00042   1 GTITSPNY--PQSYPNNLDCVWTIRAPPGYRIELQFTDFDLessdnCEYDYVEIYDGPS--ASSPLLGRFCG-SEAPPPV 75

                           90       100
                   ....*....|....*....|....*..
gi 1042779809  276 VETLSGQAVVSYHTVAWSNGRGFNATY 302
Cdd:smart00042  76 ISSSSNSLTLTFVSDSSVQKRGFSARY 102
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
140-174 2.19e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.55  E-value: 2.19e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1042779809 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
CUB pfam00431
CUB domain;
192-302 3.99e-06

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 45.75  E-value: 3.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042779809 192 CNVTLEDFYGVFSSPGYTHlasvSHPQS--CHWLLDPHDGRRLAVRFTALDL-----GFGDAVHVYDGPgpPESSRLLRS 264
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPN----PYPPNkdCVWLIRAPPGFRVKLTFQDFELedhdeCGYDYVEIRDGP--SASSPLLGR 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1042779809 265 LTHFsnGKAVTVETLSGQAVVSYHTVAWSNGRGFNATY 302
Cdd:pfam00431  75 FCGS--GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 330-353 2.74e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 38.34  E-value: 2.74e-04
                          10        20
                  ....*....|....*....|....
gi 1042779809 330 RCYSEAQRCDGSWDCADGTDEEDC 353
Cdd:cd00112    12 RCIPSSWVCDGEDDCGDGSDEENC 35
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 40-133 2.94e-03

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 37.37  E-value: 2.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042779809   40 GTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHL----ACGSERLTLR------SPLqpLISLC--EAPPSPLQL 107
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLessdNCEYDYVEIYdgpsasSPL--LGRFCgsEAPPPVISS 78

                           90       100
                   ....*....|....*....|....*.
gi 1042779809  108 PGGNVTITYSYAGARApmGQGFLLSY 133
Cdd:smart00042  79 SSNSLTLTFVSDSSVQ--KRGFSARY 102
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 330-350 5.35e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 34.53  E-value: 5.35e-03
                           10        20
                   ....*....|....*....|.
gi 1042779809  330 RCYSEAQRCDGSWDCADGTDE 350
Cdd:smart00192  13 RCIPSSWVCDGVDDCGDGSDE 33
 
Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 399-433 2.68e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.37  E-value: 2.68e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1042779809 399 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 192-302 4.28e-11

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 60.12  E-value: 4.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042779809 192 CNVTL-EDFYGVFSSPGYTHlaSVSHPQSCHWLLDPHDGRRLAVRFTALDLGFG-----DAVHVYDGPGppESSRLLRSL 265
Cdd:cd00041     1 CGGTLtASTSGTISSPNYPN--NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDGPS--TSSPLLGRF 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1042779809 266 THFSNGKavTVETLSGQAVVSYHTVAWSNGRGFNATY 302
Cdd:cd00041    77 CGSTLPP--PIISSGNSLTVRFRSDSSVTGRGFKATY 111
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 140-174 5.70e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.52  E-value: 5.70e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1042779809 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 399-430 8.98e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.79  E-value: 8.98e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1042779809  399 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
399-433 3.76e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 52.25  E-value: 3.76e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1042779809 399 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 140-171 2.62e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.55  E-value: 2.62e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1042779809  140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDE 171
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 34-134 6.86e-07

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 48.18  E-value: 6.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042779809  34 VLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHL----ACGSERLTLR----SPLQPLISLC-EAPPSP 104
Cdd:cd00041     5 LTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLesspNCSYDYLEIYdgpsTSSPLLGRFCgSTLPPP 84

                          90       100       110
                  ....*....|....*....|....*....|
gi 1042779809 105 LQLPGGNVTITYSYAGARApmGQGFLLSYS 134
Cdd:cd00041    85 IISSGNSLTVRFRSDSSVT--GRGFKATYS 112
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 201-302 9.96e-07

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 47.38  E-value: 9.96e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042779809  201 GVFSSPGYthLASVSHPQSCHWLLDPHDGRRLAVRFTALDL-----GFGDAVHVYDGPGppESSRLLRSLTHfSNGKAVT 275
Cdd:smart00042   1 GTITSPNY--PQSYPNNLDCVWTIRAPPGYRIELQFTDFDLessdnCEYDYVEIYDGPS--ASSPLLGRFCG-SEAPPPV 75

                           90       100
                   ....*....|....*....|....*..
gi 1042779809  276 VETLSGQAVVSYHTVAWSNGRGFNATY 302
Cdd:smart00042  76 ISSSSNSLTLTFVSDSSVQKRGFSARY 102
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
140-174 2.19e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 44.55  E-value: 2.19e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1042779809 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
CUB pfam00431
CUB domain;
192-302 3.99e-06

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 45.75  E-value: 3.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042779809 192 CNVTLEDFYGVFSSPGYTHlasvSHPQS--CHWLLDPHDGRRLAVRFTALDL-----GFGDAVHVYDGPgpPESSRLLRS 264
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPN----PYPPNkdCVWLIRAPPGFRVKLTFQDFELedhdeCGYDYVEIRDGP--SASSPLLGR 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1042779809 265 LTHFsnGKAVTVETLSGQAVVSYHTVAWSNGRGFNATY 302
Cdd:pfam00431  75 FCGS--GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 330-353 2.74e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 38.34  E-value: 2.74e-04
                          10        20
                  ....*....|....*....|....
gi 1042779809 330 RCYSEAQRCDGSWDCADGTDEEDC 353
Cdd:cd00112    12 RCIPSSWVCDGEDDCGDGSDEENC 35
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 40-133 2.94e-03

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 37.37  E-value: 2.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1042779809   40 GTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHL----ACGSERLTLR------SPLqpLISLC--EAPPSPLQL 107
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLessdNCEYDYVEIYdgpsasSPL--LGRFCgsEAPPPVISS 78

                           90       100
                   ....*....|....*....|....*.
gi 1042779809  108 PGGNVTITYSYAGARApmGQGFLLSY 133
Cdd:smart00042  79 SSNSLTLTFVSDSSVQ--KRGFSARY 102
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 330-350 5.35e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 34.53  E-value: 5.35e-03
                           10        20
                   ....*....|....*....|.
gi 1042779809  330 RCYSEAQRCDGSWDCADGTDE 350
Cdd:smart00192  13 RCIPSSWVCDGVDDCGDGSDE 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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