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Conserved domains on  [gi|1041818010|ref|NP_001316073|]
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tumor protein 63 isoform 7 [Homo sapiens]

Protein Classification

P53 and P53_tetramer domain-containing protein( domain architecture ID 10170140)

P53 and P53_tetramer domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P53 cd08367
P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of ...
 177-358 1.74e-97

P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes.


:

Pssm-ID: 176262  Cd Length: 179  Bit Score: 292.25  E-value: 1.74e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041818010 177 FDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEg 256
Cdd:cd08367     1 FEVTLDESGVAKSSTWTYSPKLNKLFVKMAKTCPIQFKVNPSPPPGLYVRAMLVYKDPEHVKEPVERCPNHRQGDDGHT- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041818010 257 qiAPPSHLIRVEgNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLG 336
Cdd:cd08367    80 --APNSHVIRCE-NPQAEYVGDAFTGRLSVVVPLEPPQVGSEYVTVLLQFMCQNSCPGGINRRPIQLVFTLEDENGNVLG 156

                         170       180
                  ....*....|....*....|..
gi 1041818010 337 RRCFEARICACPGRDRKADEDS 358
Cdd:cd08367   157 RRVIEVRVCACPGRDRKNEEKA 178
P53_tetramer pfam07710
P53 tetramerization motif;
391-431 8.95e-18

P53 tetramerization motif;


:

Pssm-ID: 462238  Cd Length: 42  Bit Score: 76.55  E-value: 8.95e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1041818010 391 KKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHT 431
Cdd:pfam07710   2 KRPLSSDEEEFTLPVRGRENYEMLKKIKESLELLDMVPQSQ 42
 
Name Accession Description Interval E-value
P53 cd08367
P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of ...
 177-358 1.74e-97

P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes.


Pssm-ID: 176262  Cd Length: 179  Bit Score: 292.25  E-value: 1.74e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041818010 177 FDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEg 256
Cdd:cd08367     1 FEVTLDESGVAKSSTWTYSPKLNKLFVKMAKTCPIQFKVNPSPPPGLYVRAMLVYKDPEHVKEPVERCPNHRQGDDGHT- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041818010 257 qiAPPSHLIRVEgNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLG 336
Cdd:cd08367    80 --APNSHVIRCE-NPQAEYVGDAFTGRLSVVVPLEPPQVGSEYVTVLLQFMCQNSCPGGINRRPIQLVFTLEDENGNVLG 156

                         170       180
                  ....*....|....*....|..
gi 1041818010 337 RRCFEARICACPGRDRKADEDS 358
Cdd:cd08367   157 RRVIEVRVCACPGRDRKNEEKA 178
P53 pfam00870
P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). ...
 167-358 3.19e-91

P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.


Pssm-ID: 459972 [Multi-domain]  Cd Length: 191  Bit Score: 276.47  E-value: 3.19e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041818010 167 SNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPN 246
Cdd:pfam00870   1 SEEDYPGSLNFNVLLDESKEAKKSSWTYSPKLNKLFVKMNKSCPFNFKTDPPPPPGLYIRAMLVYSKSEHANDPVERCPN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041818010 247 HELSREFNEGQIAPpsHLIRVEgNSHAQYV-EDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIV 325
Cdd:pfam00870  81 HRAKDDGNNDPIRE--HVIRCE-NPDAEYVgTDEGDERLSVVVPLEHPQAGSESVTLLLKFMCKSSCPGGINRRPTALVF 157

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1041818010 326 TLETRDGQVLGRRCFEARICACPGRDRKADEDS 358
Cdd:pfam00870 158 TLEDPDGQVLGRQSISVKVCSCPKRDRRKEEKA 190
P53_tetramer pfam07710
P53 tetramerization motif;
391-431 8.95e-18

P53 tetramerization motif;


Pssm-ID: 462238  Cd Length: 42  Bit Score: 76.55  E-value: 8.95e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1041818010 391 KKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHT 431
Cdd:pfam07710   2 KRPLSSDEEEFTLPVRGRENYEMLKKIKESLELLDMVPQSQ 42
 
Name Accession Description Interval E-value
P53 cd08367
P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of ...
 177-358 1.74e-97

P53 DNA-binding domain; P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes.


Pssm-ID: 176262  Cd Length: 179  Bit Score: 292.25  E-value: 1.74e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041818010 177 FDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEg 256
Cdd:cd08367     1 FEVTLDESGVAKSSTWTYSPKLNKLFVKMAKTCPIQFKVNPSPPPGLYVRAMLVYKDPEHVKEPVERCPNHRQGDDGHT- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041818010 257 qiAPPSHLIRVEgNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLG 336
Cdd:cd08367    80 --APNSHVIRCE-NPQAEYVGDAFTGRLSVVVPLEPPQVGSEYVTVLLQFMCQNSCPGGINRRPIQLVFTLEDENGNVLG 156

                         170       180
                  ....*....|....*....|..
gi 1041818010 337 RRCFEARICACPGRDRKADEDS 358
Cdd:cd08367   157 RRVIEVRVCACPGRDRKNEEKA 178
P53 pfam00870
P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). ...
 167-358 3.19e-91

P53 DNA-binding domain; This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.


Pssm-ID: 459972 [Multi-domain]  Cd Length: 191  Bit Score: 276.47  E-value: 3.19e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041818010 167 SNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPN 246
Cdd:pfam00870   1 SEEDYPGSLNFNVLLDESKEAKKSSWTYSPKLNKLFVKMNKSCPFNFKTDPPPPPGLYIRAMLVYSKSEHANDPVERCPN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1041818010 247 HELSREFNEGQIAPpsHLIRVEgNSHAQYV-EDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIV 325
Cdd:pfam00870  81 HRAKDDGNNDPIRE--HVIRCE-NPDAEYVgTDEGDERLSVVVPLEHPQAGSESVTLLLKFMCKSSCPGGINRRPTALVF 157

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1041818010 326 TLETRDGQVLGRRCFEARICACPGRDRKADEDS 358
Cdd:pfam00870 158 TLEDPDGQVLGRQSISVKVCSCPKRDRRKEEKA 190
P53_tetramer pfam07710
P53 tetramerization motif;
391-431 8.95e-18

P53 tetramerization motif;


Pssm-ID: 462238  Cd Length: 42  Bit Score: 76.55  E-value: 8.95e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1041818010 391 KKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHT 431
Cdd:pfam07710   2 KRPLSSDEEEFTLPVRGRENYEMLKKIKESLELLDMVPQSQ 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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