NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1040676291|ref|XP_017208486|]
View 

WD repeat-containing protein 7 [Danio rerio]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234976)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 411-623 6.97e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 6.97e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  411 KVTASVYIPSQGRLVCGREDGSIIlvpatqtaIVQLLQGEHMlrrgwpphRTLRGHRHKVTCLLYPHqvspryDQRSLVS 490
Cdd:cd00200     11 GVTCVAFSPDGKLLATGSGDGTIK--------VWDLETGELL--------RTLKGHTGPVRDVAASA------DGTYLAS 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  491 GGVDFSVIIWDIFTGEMKHIFCVHGGEITQLIVPPENcstrvqHCVCSVASDHSVGLLSLRERKCIMLASRHLFPIQVIK 570
Cdd:cd00200     69 GSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVA 142

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  571 WRPCDDYLVVGCSDGSVYVWQMDTGaldRCV-------MGITAVEILNACDEVVPAALDS 623
Cdd:cd00200    143 FSPDGTFVASSSQDGTIKLWDLRTG---KCVatltghtGEVNSVAFSPDGEKLLSSSSDG 199
WD40 COG2319
WD40 repeat [General function prediction only];
1347-1409 3.37e-10

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 3.37e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1040676291 1347 RIAVGARQGSVALYDVRTGKCQH-IHGHKGPITAVSFAPDGRYLATYSnADSHISFWQMNTSLL 1409
Cdd:COG2319    218 LLASGSADGTVRLWDLATGKLLRtLTGHSGSVRSVAFSPDGRLLASGS-ADGTVRLWDLATGEL 280
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-102 5.99e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 55.80  E-value: 5.99e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291   19 THCISSLLVMEDLATIITGSHDGQICIWDMTPELEInprALLFGHTASVTCLskaSAGSEKQYLVSASESGEMCLWDVND 98
Cdd:cd00200    177 TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL---GTLRGHENGVNSV---AFSPDGYLLASGSEDGTIRVWDLRT 250


                   ....
gi 1040676291   99 GRCI 102
Cdd:cd00200    251 GECV 254
WD40 COG2319
WD40 repeat [General function prediction only];
33-189 5.08e-07

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.76  E-value: 5.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291   33 TIITGSHDGQICIWDMTPELEInprALLFGHTASVTCLSKASAGsekQYLVSASESGEMCLWDVNDGRCIEftklacAHT 112
Cdd:COG2319    260 LLASGSADGTVRLWDLATGELL---RTLTGHSGGVNSVAFSPDG---KLLASGSDDGTVRLWDLATGKLLR------TLT 327

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1040676291  113 GIQFYQFTIGTQREGRLLCHGHYPE-ILVMDATSLEVLYSLVSkiSPDWISSMSIIRSHRtqedTVVAVSVTGILKVW 189
Cdd:COG2319    328 GHTGAVRSVAFSPDGKTLASGSDDGtVRLWDLATGELLRTLTG--HTGAVTSVAFSPDGR----TLASGSADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 411-623 6.97e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 6.97e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  411 KVTASVYIPSQGRLVCGREDGSIIlvpatqtaIVQLLQGEHMlrrgwpphRTLRGHRHKVTCLLYPHqvspryDQRSLVS 490
Cdd:cd00200     11 GVTCVAFSPDGKLLATGSGDGTIK--------VWDLETGELL--------RTLKGHTGPVRDVAASA------DGTYLAS 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  491 GGVDFSVIIWDIFTGEMKHIFCVHGGEITQLIVPPENcstrvqHCVCSVASDHSVGLLSLRERKCIMLASRHLFPIQVIK 570
Cdd:cd00200     69 GSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVA 142

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  571 WRPCDDYLVVGCSDGSVYVWQMDTGaldRCV-------MGITAVEILNACDEVVPAALDS 623
Cdd:cd00200    143 FSPDGTFVASSSQDGTIKLWDLRTG---KCVatltghtGEVNSVAFSPDGEKLLSSSSDG 199
WD40 COG2319
WD40 repeat [General function prediction only];
399-607 8.24e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 8.24e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  399 QLSVLPGASEPikVTASVYIPSQGRLVCGREDGSIILVPATQTAIVqllqgehmlrrgwpphRTLRGHRHKVTCLLYphq 478
Cdd:COG2319    196 LLRTLTGHTGA--VRSVAFSPDGKLLASGSADGTVRLWDLATGKLL----------------RTLTGHSGSVRSVAF--- 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  479 vSPryDQRSLVSGGVDFSVIIWDIFTGEMKHIFCVHGGEITQLIVPPENcstrvQHcVCSVASDHSVGLLSLRERKCIML 558
Cdd:COG2319    255 -SP--DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG-----KL-LASGSDDGTVRLWDLATGKLLRT 325

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1040676291  559 ASRHLFPIQVIKWRPCDDYLVVGCSDGSVYVWQMDTGALDRCVMG----ITAV 607
Cdd:COG2319    326 LTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhtgaVTSV 378
WD40 COG2319
WD40 repeat [General function prediction only];
1347-1409 3.37e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 3.37e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1040676291 1347 RIAVGARQGSVALYDVRTGKCQH-IHGHKGPITAVSFAPDGRYLATYSnADSHISFWQMNTSLL 1409
Cdd:COG2319    218 LLASGSADGTVRLWDLATGKLLRtLTGHSGSVRSVAFSPDGRLLASGS-ADGTVRLWDLATGEL 280
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1337-1406 5.09e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 5.09e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1040676291 1337 YMVAYCERSYRIAVGARQGSVALYDVRTGKCQH-IHGHKGPITAVSFAPDGRYLATYSnADSHISFWQMNT 1406
Cdd:cd00200    181 NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGtLRGHENGVNSVAFSPDGYLLASGS-EDGTIRVWDLRT 250
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-102 5.99e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.80  E-value: 5.99e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291   19 THCISSLLVMEDLATIITGSHDGQICIWDMTPELEInprALLFGHTASVTCLskaSAGSEKQYLVSASESGEMCLWDVND 98
Cdd:cd00200    177 TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL---GTLRGHENGVNSV---AFSPDGYLLASGSEDGTIRVWDLRT 250


                   ....
gi 1040676291   99 GRCI 102
Cdd:cd00200    251 GECV 254
WD40 COG2319
WD40 repeat [General function prediction only];
33-102 1.30e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 1.30e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291   33 TIITGSHDGQICIWDMTPELEInprALLFGHTASVTCLSKASAGsekQYLVSASESGEMCLWDVNDGRCI 102
Cdd:COG2319    218 LLASGSADGTVRLWDLATGKLL---RTLTGHSGSVRSVAFSPDG---RLLASGSADGTVRLWDLATGELL 281
WD40 COG2319
WD40 repeat [General function prediction only];
33-189 5.08e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.76  E-value: 5.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291   33 TIITGSHDGQICIWDMTPELEInprALLFGHTASVTCLSKASAGsekQYLVSASESGEMCLWDVNDGRCIEftklacAHT 112
Cdd:COG2319    260 LLASGSADGTVRLWDLATGELL---RTLTGHSGGVNSVAFSPDG---KLLASGSDDGTVRLWDLATGKLLR------TLT 327

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1040676291  113 GIQFYQFTIGTQREGRLLCHGHYPE-ILVMDATSLEVLYSLVSkiSPDWISSMSIIRSHRtqedTVVAVSVTGILKVW 189
Cdd:COG2319    328 GHTGAVRSVAFSPDGKTLASGSDDGtVRLWDLATGELLRTLTG--HTGAVTSVAFSPDGR----TLASGSADGTVRLW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1364-1402 8.96e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 8.96e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1040676291  1364 TGKCQH-IHGHKGPITAVSFAPDGRYLATYSnADSHISFW 1402
Cdd:smart00320    1 SGELLKtLKGHTGPVTSVAFSPDGKYLASGS-DDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
1365-1402 1.44e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 1.44e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1040676291 1365 GKCQH-IHGHKGPITAVSFAPDGRYLATySNADSHISFW 1402
Cdd:pfam00400    1 GKLLKtLEGHTGSVTSLAFSPDGKLLAS-GSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 457-501 3.50e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 3.50e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1040676291   457 WPPHRTLRGHRHKVTCLlyphQVSPryDQRSLVSGGVDFSVIIWD 501
Cdd:smart00320    2 GELLKTLKGHTGPVTSV----AFSP--DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
457-501 1.12e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 1.12e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1040676291  457 WPPHRTLRGHRHKVTCLLYPHqvspryDQRSLVSGGVDFSVIIWD 501
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP------DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 411-623 6.97e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 6.97e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  411 KVTASVYIPSQGRLVCGREDGSIIlvpatqtaIVQLLQGEHMlrrgwpphRTLRGHRHKVTCLLYPHqvspryDQRSLVS 490
Cdd:cd00200     11 GVTCVAFSPDGKLLATGSGDGTIK--------VWDLETGELL--------RTLKGHTGPVRDVAASA------DGTYLAS 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  491 GGVDFSVIIWDIFTGEMKHIFCVHGGEITQLIVPPENcstrvqHCVCSVASDHSVGLLSLRERKCIMLASRHLFPIQVIK 570
Cdd:cd00200     69 GSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVA 142

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  571 WRPCDDYLVVGCSDGSVYVWQMDTGaldRCV-------MGITAVEILNACDEVVPAALDS 623
Cdd:cd00200    143 FSPDGTFVASSSQDGTIKLWDLRTG---KCVatltghtGEVNSVAFSPDGEKLLSSSSDG 199
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 398-597 2.95e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.15  E-value: 2.95e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  398 DQLSVLPGASEPikVTASVYIPSQGRLVCGREDGSIILVPATQTAIVqllqgehmlrrgwpphRTLRGHRHKVTCLLYph 477
Cdd:cd00200     42 ELLRTLKGHTGP--VRDVAASADGTYLASGSSDKTIRLWDLETGECV----------------RTLTGHTSYVSSVAF-- 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  478 qvSPryDQRSLVSGGVDFSVIIWDIFTGEMKHIFCVHGGEITQLIVPPENcstrvqHCVCSVASDHSVGLLSLRERKCIM 557
Cdd:cd00200    102 --SP--DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG------TFVASSSQDGTIKLWDLRTGKCVA 171

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1040676291  558 LASRHLFPIQVIKWRPCDDYLVVGCSDGSVYVWQMDTGAL 597
Cdd:cd00200    172 TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC 211
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 412-600 7.46e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.91  E-value: 7.46e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  412 VTASVYIPSQGRLVCGREDGSIIL--VPATQtaivqllqgehmlrrgwpPHRTLRGHRHKVTCLLYPHqvspryDQRSLV 489
Cdd:cd00200     96 VSSVAFSPDGRILSSSSRDKTIKVwdVETGK------------------CLTTLRGHTDWVNSVAFSP------DGTFVA 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  490 SGGVDFSVIIWDIFTGEMKHIFCVHGGEITQLIVPPENCStrvqhcVCSVASDHSVGLLSLRERKCIMLASRHLFPIQVI 569
Cdd:cd00200    152 SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEK------LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV 225

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1040676291  570 KWRPcDDYLVVGCS-DGSVYVWQMDTGALDRC 600
Cdd:cd00200    226 AFSP-DGYLLASGSeDGTIRVWDLRTGECVQT 256
WD40 COG2319
WD40 repeat [General function prediction only];
399-607 8.24e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 8.24e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  399 QLSVLPGASEPikVTASVYIPSQGRLVCGREDGSIILVPATQTAIVqllqgehmlrrgwpphRTLRGHRHKVTCLLYphq 478
Cdd:COG2319    196 LLRTLTGHTGA--VRSVAFSPDGKLLASGSADGTVRLWDLATGKLL----------------RTLTGHSGSVRSVAF--- 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  479 vSPryDQRSLVSGGVDFSVIIWDIFTGEMKHIFCVHGGEITQLIVPPENcstrvQHcVCSVASDHSVGLLSLRERKCIML 558
Cdd:COG2319    255 -SP--DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG-----KL-LASGSDDGTVRLWDLATGKLLRT 325

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1040676291  559 ASRHLFPIQVIKWRPCDDYLVVGCSDGSVYVWQMDTGALDRCVMG----ITAV 607
Cdd:COG2319    326 LTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhtgaVTSV 378
WD40 COG2319
WD40 repeat [General function prediction only];
346-597 9.17e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.78  E-value: 9.17e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  346 QGDSAGRLTVWSIPDASPPIQQLTSATELQVSVSISLQEAFDKLLPAPAGIIDQLSVLPGASEPIKVTASVYIPSQGRLV 425
Cdd:COG2319      9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  426 CGRedgsiILVPATQTAIVQLLQgehmlRRGWPPHRTLRGHRHKVTCLlyphQVSPryDQRSLVSGGVDFSVIIWDIFTG 505
Cdd:COG2319     89 DGR-----LLASASADGTVRLWD-----LATGLLLRTLTGHTGAVRSV----AFSP--DGKTLASGSADGTVRLWDLATG 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  506 EMKHIFCVHGGEIT--------QLIVppencstrvqhcvcSVASDHSVGLLSLRERKCIMLASRHLFPIQVIKWRPCDDY 577
Cdd:COG2319    153 KLLRTLTGHSGAVTsvafspdgKLLA--------------SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL 218

                          250       260
                   ....*....|....*....|
gi 1040676291  578 LVVGCSDGSVYVWQMDTGAL 597
Cdd:COG2319    219 LASGSADGTVRLWDLATGKL 238
WD40 COG2319
WD40 repeat [General function prediction only];
1347-1409 3.37e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 3.37e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1040676291 1347 RIAVGARQGSVALYDVRTGKCQH-IHGHKGPITAVSFAPDGRYLATYSnADSHISFWQMNTSLL 1409
Cdd:COG2319    218 LLASGSADGTVRLWDLATGKLLRtLTGHSGSVRSVAFSPDGRLLASGS-ADGTVRLWDLATGEL 280
WD40 COG2319
WD40 repeat [General function prediction only];
1347-1406 3.88e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 3.88e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1040676291 1347 RIAVGARQGSVALYDVRTGKCQH-IHGHKGPITAVSFAPDGRYLATYSnADSHISFWQMNT 1406
Cdd:COG2319    176 LLASGSDDGTVRLWDLATGKLLRtLTGHTGAVRSVAFSPDGKLLASGS-ADGTVRLWDLAT 235
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 399-591 3.90e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.74  E-value: 3.90e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  399 QLSVLPGASEPIKVTAsvYIPSQGRLVCGREDGSIILV-PATQTAIvqllqgehmlrrgwpphRTLRGHRHKVTCLlyph 477
Cdd:cd00200    127 CLTTLRGHTDWVNSVA--FSPDGTFVASSSQDGTIKLWdLRTGKCV-----------------ATLTGHTGEVNSV---- 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  478 QVSPryDQRSLVSGGVDFSVIIWDIFTGEMKHIFCVHGGEITQLIVPPENcstrvqHCVCSVASDHSVGLLSLRERKCIM 557
Cdd:cd00200    184 AFSP--DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG------YLLASGSEDGTIRVWDLRTGECVQ 255

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1040676291  558 LASRHLFPIQVIKWRPCDDYLVVGCSDGSVYVWQ 591
Cdd:cd00200    256 TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
1347-1406 4.06e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 4.06e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1040676291 1347 RIAVGARQGSVALYDVRTGKCQH-IHGHKGPITAVSFAPDGRYLATySNADSHISFWQMNT 1406
Cdd:COG2319    260 LLASGSADGTVRLWDLATGELLRtLTGHSGGVNSVAFSPDGKLLAS-GSDDGTVRLWDLAT 319
WD40 COG2319
WD40 repeat [General function prediction only];
1347-1406 7.57e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.01  E-value: 7.57e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1040676291 1347 RIAVGARQGSVALYDVRTGKCQH-IHGHKGPITAVSFAPDGRYLATySNADSHISFWQMNT 1406
Cdd:COG2319    134 TLASGSADGTVRLWDLATGKLLRtLTGHSGAVTSVAFSPDGKLLAS-GSDDGTVRLWDLAT 193
WD40 COG2319
WD40 repeat [General function prediction only];
1347-1406 1.35e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.85  E-value: 1.35e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1040676291 1347 RIAVGARQGSVALYDVRTGKCQH-IHGHKGPITAVSFAPDGRYLATYSnADSHISFWQMNT 1406
Cdd:COG2319    344 TLASGSDDGTVRLWDLATGELLRtLTGHTGAVTSVAFSPDGRTLASGS-ADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
1347-1409 2.23e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 2.23e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1040676291 1347 RIAVGARQGSVALYDVRTGKCQHIH-GHKGPITAVSFAPDGRYLATYSnADSHISFWQMNTSLL 1409
Cdd:COG2319    302 LLASGSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKTLASGS-DDGTVRLWDLATGEL 364
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1337-1406 5.09e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 5.09e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1040676291 1337 YMVAYCERSYRIAVGARQGSVALYDVRTGKCQH-IHGHKGPITAVSFAPDGRYLATYSnADSHISFWQMNT 1406
Cdd:cd00200    181 NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGtLRGHENGVNSVAFSPDGYLLASGS-EDGTIRVWDLRT 250
WD40 COG2319
WD40 repeat [General function prediction only];
1347-1406 2.60e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 2.60e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1040676291 1347 RIAVGARQGSVALYDVRTGKCQHI-HGHKGPITAVSFAPDGRYLATYSnADSHISFWQMNT 1406
Cdd:COG2319     92 LLASASADGTVRLWDLATGLLLRTlTGHTGAVRSVAFSPDGKTLASGS-ADGTVRLWDLAT 151
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1348-1406 5.27e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.19  E-value: 5.27e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291 1348 IAVGARQGSVALYDVRTGKCQH-IHGHKGPITAVSFAPDGRYLATYSNaDSHISFWQMNT 1406
Cdd:cd00200    108 LSSSSRDKTIKVWDVETGKCLTtLRGHTDWVNSVAFSPDGTFVASSSQ-DGTIKLWDLRT 166
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-102 5.99e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.80  E-value: 5.99e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291   19 THCISSLLVMEDLATIITGSHDGQICIWDMTPELEInprALLFGHTASVTCLskaSAGSEKQYLVSASESGEMCLWDVND 98
Cdd:cd00200    177 TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL---GTLRGHENGVNSV---AFSPDGYLLASGSEDGTIRVWDLRT 250


                   ....
gi 1040676291   99 GRCI 102
Cdd:cd00200    251 GECV 254
WD40 COG2319
WD40 repeat [General function prediction only];
33-102 1.30e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 1.30e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291   33 TIITGSHDGQICIWDMTPELEInprALLFGHTASVTCLSKASAGsekQYLVSASESGEMCLWDVNDGRCI 102
Cdd:COG2319    218 LLASGSADGTVRLWDLATGKLL---RTLTGHSGSVRSVAFSPDG---RLLASGSADGTVRLWDLATGELL 281
WD40 COG2319
WD40 repeat [General function prediction only];
453-599 1.35e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 1.35e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  453 LRRGWPPHRTLRGHRHKVTcllyphQVSPRYDQRSLVSGGVDFSVIIWDIFTGEMKHIFCVHGGEITQLIVPPeNCSTRV 532
Cdd:COG2319     64 DAAAGALLATLLGHTAAVL------SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLA 136

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1040676291  533 qhcvcSVASDHSVGLLSLRERKCIMLASRHLFPIQVIKWRPcD-DYLVVGCSDGSVYVWQMDTGALDR 599
Cdd:COG2319    137 -----SGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP-DgKLLASGSDDGTVRLWDLATGKLLR 198
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1339-1406 1.92e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.26  E-value: 1.92e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1040676291 1339 VAYCERSYRIAVGARQGSVALYDVRTGKCQH-IHGHKGPITAVSFAPDGRYLATySNADSHISFWQMNT 1406
Cdd:cd00200    141 VAFSPDGTFVASSSQDGTIKLWDLRTGKCVAtLTGHTGEVNSVAFSPDGEKLLS-SSSDGTIKLWDLST 208
WD40 COG2319
WD40 repeat [General function prediction only];
33-102 1.98e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 1.98e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291   33 TIITGSHDGQICIWDMTPELEInprALLFGHTASVTCLSKASAGsekQYLVSASESGEMCLWDVNDGRCI 102
Cdd:COG2319    176 LLASGSDDGTVRLWDLATGKLL---RTLTGHTGAVRSVAFSPDG---KLLASGSADGTVRLWDLATGKLL 239
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1339-1403 3.20e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 3.20e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1040676291 1339 VAYCERSYRIAVGARQGSVALYDVRTGKC-QHIHGHKGPITAVSFAPDGRYLATYSnADSHISFWQ 1403
Cdd:cd00200    225 VAFSPDGYLLASGSEDGTIRVWDLRTGECvQTLSGHTNSVTSLAWSPDGKRLASGS-ADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
33-189 5.08e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.76  E-value: 5.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291   33 TIITGSHDGQICIWDMTPELEInprALLFGHTASVTCLSKASAGsekQYLVSASESGEMCLWDVNDGRCIEftklacAHT 112
Cdd:COG2319    260 LLASGSADGTVRLWDLATGELL---RTLTGHSGGVNSVAFSPDG---KLLASGSDDGTVRLWDLATGKLLR------TLT 327

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1040676291  113 GIQFYQFTIGTQREGRLLCHGHYPE-ILVMDATSLEVLYSLVSkiSPDWISSMSIIRSHRtqedTVVAVSVTGILKVW 189
Cdd:COG2319    328 GHTGAVRSVAFSPDGKTLASGSDDGtVRLWDLATGELLRTLTG--HTGAVTSVAFSPDGR----TLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
33-102 6.54e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.38  E-value: 6.54e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1040676291   33 TIITGSHDGQICIWDM-TPELeinpRALLFGHTASVTCLSKASAGsekQYLVSASESGEMCLWDVNDGRCI 102
Cdd:COG2319    134 TLASGSADGTVRLWDLaTGKL----LRTLTGHSGAVTSVAFSPDG---KLLASGSDDGTVRLWDLATGKLL 197
WD40 COG2319
WD40 repeat [General function prediction only];
22-504 1.26e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.61  E-value: 1.26e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291   22 ISSLLVMEDLATIITGSHDGQICIWDMTPELeinPRALLFGHTASVTCLSKASAGsekQYLVSASESGEMCLWDVNDGRC 101
Cdd:COG2319     81 VLSVAFSPDGRLLASASADGTVRLWDLATGL---LLRTLTGHTGAVRSVAFSPDG---KTLASGSADGTVRLWDLATGKL 154

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  102 IeftklacahtgiqfyqftigtqregRLLcHGHYPEIlvmdatslevlYSLVskISPDwissmsiirshrtqEDTVVAVS 181
Cdd:COG2319    155 L-------------------------RTL-TGHSGAV-----------TSVA--FSPD--------------GKLLASGS 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  182 VTGILKVWiitaDVSRmQDLDPVFEEESKPIYcqgcqSISFctftqlS----LLVVCS--KYWRVFDAGDFSLLCSVSSE 255
Cdd:COG2319    182 DDGTVRLW----DLAT-GKLLRTLTGHTGAVR-----SVAF------SpdgkLLASGSadGTVRLWDLATGKLLRTLTGH 245

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  256 NNQSWA-----GGEFIAA---DKVI-IW-TEDGcsyiyklpaSCLPASEHFRSNvgkksegsipplVYSIADQADKQLLI 325
Cdd:COG2319    246 SGSVRSvafspDGRLLASgsaDGTVrLWdLATG---------ELLRTLTGHSGG------------VNSVAFSPDGKLLA 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  326 CppvtrfffgrrepfhkllmqGDSAGRLTVWSIPDASpPIQQLTSATELQVSVSISlqeafdkllpapagiidqlsvlpg 405
Cdd:COG2319    305 S--------------------GSDDGTVRLWDLATGK-LLRTLTGHTGAVRSVAFS------------------------ 339

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  406 asepikvtasvyiPSQGRLVCGREDGSIILVPAtqtaivqllqgehmlrRGWPPHRTLRGHRHKVTCLLYphqvSPryDQ 485
Cdd:COG2319    340 -------------PDGKTLASGSDDGTVRLWDL----------------ATGELLRTLTGHTGAVTSVAF----SP--DG 384

                          490
                   ....*....|....*....
gi 1040676291  486 RSLVSGGVDFSVIIWDIFT 504
Cdd:COG2319    385 RTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1339-1406 1.45e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.57  E-value: 1.45e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1040676291 1339 VAYCERSYRIAVGARQGSVALYDVRTGKCQH-IHGHKGPITAVSFAPDGRYLATySNADSHISFWQMNT 1406
Cdd:cd00200     57 VAASADGTYLASGSSDKTIRLWDLETGECVRtLTGHTSYVSSVAFSPDGRILSS-SSRDKTIKVWDVET 124
WD40 COG2319
WD40 repeat [General function prediction only];
11-98 1.60e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.22  E-value: 1.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291   11 VLWSRNAPTHCISSLLVMEDLATIITGSHDGQICIWDMTPELEINPralLFGHTASVTCLSKASAGsekQYLVSASESGE 90
Cdd:COG2319    322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT---LTGHTGAVTSVAFSPDG---RTLASGSADGT 395


                   ....*...
gi 1040676291   91 MCLWDVND 98
Cdd:COG2319    396 VRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-274 3.34e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 3.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291   19 THCISSLLVMEDLATIITGSHDGQICIWDMTPELEINPralLFGHTASVTCLSKASAGsekQYLVSASESGEMCLWDVND 98
Cdd:cd00200     51 TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT---LTGHTSYVSSVAFSPDG---RILSSSSRDKTIKVWDVET 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291   99 GRCIefTKLACaHTG----IQFyqftigtQREGRLLCHGHYP-EILVMDATSLEVLYSLvsKISPDWISSMSIIrshrTQ 173
Cdd:cd00200    125 GKCL--TTLRG-HTDwvnsVAF-------SPDGTFVASSSQDgTIKLWDLRTGKCVATL--TGHTGEVNSVAFS----PD 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  174 EDTVVAVSVTGILKVWiitaDVsRMQDLDPVFEEESKPIYCqgcqsisfCTFTQLSLLVVCSKYW---RVFDAGDFSLLC 250
Cdd:cd00200    189 GEKLLSSSSDGTIKLW----DL-STGKCLGTLRGHENGVNS--------VAFSPDGYLLASGSEDgtiRVWDLRTGECVQ 255

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1040676291  251 SVSSENNQSWA------GGEFIAA--DK-VIIW 274
Cdd:cd00200    256 TLSGHTNSVTSlawspdGKRLASGsaDGtIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1364-1402 8.96e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 8.96e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1040676291  1364 TGKCQH-IHGHKGPITAVSFAPDGRYLATYSnADSHISFW 1402
Cdd:smart00320    1 SGELLKtLKGHTGPVTSVAFSPDGKYLASGS-DDGTIKLW 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 33-287 1.02e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.26  E-value: 1.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291   33 TIITGSHDGQICIWDMTPELEInprALLFGHTASVTCLSkASAGSekQYLVSASESGEMCLWDVNDGRCI-EFTklacAH 111
Cdd:cd00200     23 LLATGSGDGTIKVWDLETGELL---RTLKGHTGPVRDVA-ASADG--TYLASGSSDKTIRLWDLETGECVrTLT----GH 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  112 TG----IQFYQftigtqrEGRLLCHGHY-PEILVMDATSLEVLYSLVSKisPDWISSMSIIRSHRtqedTVVAVSVTGIL 186
Cdd:cd00200     93 TSyvssVAFSP-------DGRILSSSSRdKTIKVWDVETGKCLTTLRGH--TDWVNSVAFSPDGT----FVASSSQDGTI 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040676291  187 KVWIITADVSRMqdldpVFEEESKPIYCqgcqsISFctFTQLSLLVVCS--KYWRVFDAGDFSLLCSVSSENNQSWA--- 261
Cdd:cd00200    160 KLWDLRTGKCVA-----TLTGHTGEVNS-----VAF--SPDGEKLLSSSsdGTIKLWDLSTGKCLGTLRGHENGVNSvaf 227

                          250       260       270
                   ....*....|....*....|....*....|..
gi 1040676291  262 --GGEFIAA---DKVI-IWTEDGCSYIYKLPA 287
Cdd:cd00200    228 spDGYLLASgseDGTIrVWDLRTGECVQTLSG 259
WD40 pfam00400
WD domain, G-beta repeat;
1365-1402 1.44e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 1.44e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1040676291 1365 GKCQH-IHGHKGPITAVSFAPDGRYLATySNADSHISFW 1402
Cdd:pfam00400    1 GKLLKtLEGHTGSVTSLAFSPDGKLLAS-GSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 457-501 3.50e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 3.50e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1040676291   457 WPPHRTLRGHRHKVTCLlyphQVSPryDQRSLVSGGVDFSVIIWD 501
Cdd:smart00320    2 GELLKTLKGHTGPVTSV----AFSP--DGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1347-1406 6.55e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.48  E-value: 6.55e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1040676291 1347 RIAVGARQGSVALYDVRTGKCQH-IHGHKGPITAVSFAPDGRYLATYSNaDSHISFWQMNT 1406
Cdd:cd00200     23 LLATGSGDGTIKVWDLETGELLRtLKGHTGPVRDVAASADGTYLASGSS-DKTIRLWDLET 82
WD40 pfam00400
WD domain, G-beta repeat;
457-501 1.12e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 1.12e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1040676291  457 WPPHRTLRGHRHKVTCLLYPHqvspryDQRSLVSGGVDFSVIIWD 501
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP------DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 553-590 2.00e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 2.00e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1040676291   553 RKCIMLASRHLFPIQVIKWRPCDDYLVVGCSDGSVYVW 590
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 562-603 6.00e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 6.00e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1040676291  562 HLFPIQVIKWRPCDDYLVVGCSDGSVYVWQMDTGALDRCVMG 603
Cdd:cd00200      8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH