|
Name |
Accession |
Description |
Interval |
E-value |
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
25-1250 |
0e+00 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 1737.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 25 CVWYGECGIATGDKRYNCKYSGPPKPLPKDGYDLVQELCpGLFFDNVS--LCCDIQQLQTLKSNLQLPLQFLSRCPSCFY 102
Cdd:TIGR00917 1 CAMYDICGARSDGKVLNCPYNIPSVKPPDLLSSLIQSLC-QYSHPTISgnVCCTETQFDTLRSNVQQAIPFIVRCPACLR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 103 NLMTLFCELTCSPHQSQFLNVTATEDyfdpktQENKTNVKELEYFVGQSFANAMYNACRDVEAPSSNEKALGLLCGRDAR 182
Cdd:TIGR00917 80 NFLNLFCELTCSPDQSLFINVTSTTK------VKTNSTVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGAKN 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 183 ACNATNWIEYMFNKDNGQAPFTIIPVFSDLSIL-GMEPMRNATKGCNESVDEVTGPCSCQDCSIVCGPKPQPPPPPMPWR 261
Cdd:TIGR00917 154 FKEWFNWIGQKAGVNLPGAPYGIAFLPTPCPVSsGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCKAKVPTQKKHSCSI 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 262 IWGLDAMYVIMWVTYVAFLFVFFG--ALLAVWCHR-RYFVSEYTPIDSNIAFSVNSSDKGEASCCDPLGAAFDDCLRRMF 338
Cdd:TIGR00917 234 KLGVKCVDFILAILYIVLVSVFLGggLLHPVRGKKkTSQMGTLSEADGEINSVNQQKDQNTPQRNWGQLSTVQGHLARFF 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 339 TKWGAFCVRNPTCIIFFSLAFITVCSSGLVFVQVTTNPVELWSAPHSQARLEKEYFDKHFGPFFRTEQLIIQAPNTSvhi 418
Cdd:TIGR00917 314 GKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIATVQTS--- 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 419 yepypagADVPFGPPLNKEILHQVLDLQIAIESITASYNNETVTLQDICVAPLSPYNknCTIMSVLNYFQNSHAVLDSQV 498
Cdd:TIGR00917 391 -------SHEKAPEILTDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKPNHPYN--CFIYSTCKKLQNMYSKLKPEN 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 499 GDDFYIyADYHTHFLYCVRAPAslndtsllhgPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTERLQR 578
Cdd:TIGR00917 462 YDDYGG-VDYVKYCFEHFTSPE----------SCLSAFGGPVDPTTVLGGFSGNNFSEASAFVVTFPVNNFVNKTNKTEK 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 579 AWAWEKEFISFVKNYKNPNL--TISFTAERSIEDELNRESNSDVFTVIISYVVMFLYISLALGHIQSCSRLLVDSKISLG 656
Cdd:TIGR00917 531 AVAWEKAFIQLAKDELLPMVqaTISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLGDSPRLKSLYVTSKVLLG 610
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 657 IAGILIVLSSVACSLGIFSYMGMPLTLIVIEVIPFLVLAVGVDNIFILVQTYQRDERLQ---------EETLDQQLGRIL 727
Cdd:TIGR00917 611 LSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYFYLEYFYrqvgvdneqELTLERRLSRAL 690
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 728 GEVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDIKRQEKNHLDILCCVRGADDGQ 807
Cdd:TIGR00917 691 MEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPCIKTSKSSI 770
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 808 G-----SHASESYLFRFFKNYFAPLLLKDWLRPIVVAVFVGVLSFSVAVVNKVDIGLDQSLSMPNDSYVIDYFKSLAQYL 882
Cdd:TIGR00917 771 SaekgsGQRKAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFASLTPLL 850
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 883 HSGPPVYFVLEEGYNYSSRKGQNMVCGGMGCDNDSLVQQifnaaeLDTYTRVGFAPSSWIDDYFDWVSPQSSCCRLYNVT 962
Cdd:TIGR00917 851 EVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVNV------FNNLSYIAKPASSWLDDYLVWLSPQASCCCRKFTN 924
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 963 HQFCNasVMDPTCVRCRPLTPEGKQRPQGKEFMKFLPMFLSDNPNPKCGKGGHAAYGSAVNIVGDDTYIGATYFMTYHTI 1042
Cdd:TIGR00917 925 GTFCN--GPDPQCFRCADLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVDLQGYATIIQASSFRTYHTP 1002
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 1043 LKTSADYTDAMKKARLIASNITEtmrskGSDYRVFPYSVFYVFYEQYLTIIDDTIFNLSVSLGSIFLVTLVVLGCELWSA 1122
Cdd:TIGR00917 1003 LNTQVDFINAMRAAQEFAAKVSR-----SSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQLNALSV 1077
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 1123 VIMCITIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTMSTKGSRVSRAEEALAHMGSSVFSGITL 1202
Cdd:TIGR00917 1078 VNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGITL 1157
|
1210 1220 1230 1240
....*....|....*....|....*....|....*....|....*...
gi 1039755706 1203 TKFGGIVVLAFAKSQIFEIFYFRMYLAMVLLGATHGLIFLPVLLSYIG 1250
Cdd:TIGR00917 1158 TKLVGVVVLGFSRSEIFVVYYFRMYLALVLLGFLHGLVFLPVLLSVLG 1205
|
|
| NPC1_N |
pfam16414 |
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. ... |
23-247 |
6.15e-92 |
|
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.
Pssm-ID: 465110 Cd Length: 239 Bit Score: 296.05 E-value: 6.15e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 23 QSCVWYGECGIAT-GDKRYNCKYSGPPKPLPKDGYDLVQELCPGLFFDNVSLCCDIQQLQTLKSNLQLPLQFLSRCPSCF 101
Cdd:pfam16414 1 GRCAWYGECGKKSlFGKDLPCPYNGPAKPLDDEVRDLLAELCPLLFADETPVCCDADQLNTLRSNLKLAEGLLSRCPACK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 102 YNLMTLFCELTCSPHQSQFLNVTATEdyfdpKTQENKTNVKELEYFVGQSFANAMYNACRDVEAPSSNEKALGLLCGrda 181
Cdd:pfam16414 81 KNFANLFCEFTCSPNQSTFLNVTKTK-----KSVDGKEYVTELDYYISEEYASGFYDSCKDVKFPATNGYAMDLICG--- 152
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039755706 182 RACNATNWIEYMFNKDNGQAPFTIIPVFSDLSI-LGMEPMRNATKGCNESVDEvTGPCSCQDCSIVC 247
Cdd:pfam16414 153 GACNYTRWLKFMGDKKNGGSPFQINFPDPPEEDpSGMVPLNPNTKDCNESYDA-SYACSCVDCPLSC 218
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
480-1247 |
5.44e-71 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 254.59 E-value: 5.44e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 480 IMSVLNYFQNSHAVldsQVGDDFYIYADYHTHFLYC---VRAPASLNDTSLLHG-------PCLGTFGGPVFPWLVLGG- 548
Cdd:pfam02460 67 IYQLNDYISTNVEI---QVDGIIISFKDLCSRYCDLncpVNKHYNGMLLSRRHNtridityPIMPVLGTPIYLGPHFGGv 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 549 --YDDQNYNNATALVITFPVNnyYNDTERLQRAWAWEKEFISFVKN-YKNPNLTISFTAERSIEDELNRESNSDVFTVII 625
Cdd:pfam02460 144 dfEPPGNISYAKAIVLWYFLK--FDEEEVEEDSKEWEDELSQLLHNkYASEHIQFTIFHDQILNDELVRNALTLTPFFVI 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 626 SYVVMFLYISLALGHIQSCSRLLVDSKISLGIAGILIVLSSVACSLGIFSYMGMPLTLIVIeVIPFLVLAVGVDNIFILV 705
Cdd:pfam02460 222 GFFLLLTFSIIVSVTLSSYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVC-VTPFLVLAIGVDDMFLMV 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 706 QTYQRDERlqEETLDQQLGRILGEVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLD 785
Cdd:pfam02460 301 AAWQRTTA--TLSVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAIC 378
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 786 IKRQ-EKNHLDILC-------CVRGADDGQGSHASESYLFRFFKNYFAPLLLKDWLRPIVVAVFVGVLSFSVAVVNKVDI 857
Cdd:pfam02460 379 AKPEaEGRHCLFVWatsspqrIDSEGSEPDKSHNIEQLKSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKE 458
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 858 GLDQSLSMPNDSYVIDYFKSLAQYL-HSGPPVYFVLEEGYNYS---SRKGQNmvcggmgcdndslvqQIFNAAELDTYTR 933
Cdd:pfam02460 459 GLEPDKLVLEDSPLVEYLSLREKHFwPEGLQIQVAVNNPPNLTipeSRDRMN---------------EMVDEFENTPYSL 523
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 934 VGFAPSSWIDDYFDWVSPQssccrlynvthqfcNASVMD----PTCVRCRPLTPEGKQRPQGKEFMKFlpmflsdnpnpk 1009
Cdd:pfam02460 524 GPNSTLFWLREYENFLSTL--------------NMEEEEdeekEWSYGNLPSFLKAPGNSHWAGDLVW------------ 577
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 1010 cgkgghaaygsavnivGDDTYIGATY-FMTYHTILKTSADYTDAMKKARLIAsnitetmrSKGSDYRVFPYSVFYVFYEQ 1088
Cdd:pfam02460 578 ----------------DDNTTMVTKFrFTLAGKGLSTWNDRTRALQEWRSIA--------DQYPEFNVTVFDEDAPFADQ 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 1089 YLTIIDDTIFNLSVSLGSIFLVTLVVLGcELWSAVIMCITIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSH 1168
Cdd:pfam02460 634 YLTILPSTIQNIVITLICMFIVCFLFIP-NPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAH 712
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039755706 1169 ITRAFTMSTKGSRVSRAEEALAHMGSSVFSGITLTkFGGIVVLAFAKSQIFEIFYFRMYLaMVLLGATHGLIFLPVLLS 1247
Cdd:pfam02460 713 IAYHFVRSRGDTPAERVVDALEALGWPVFQGGLST-ILGVLVLLFVPSYMVVVFFKTVFL-VVAIGLLHGLFILPIILS 789
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
648-802 |
3.32e-61 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 205.90 E-value: 3.32e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 648 LVDSKISLGIAGILIVLSSVACSLGIFSYMGMPLTLIVIEVIPFLVLAVGVDNIFILVQTYQRDERlqEETLDQQLGRIL 727
Cdd:pfam12349 1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPR--SLDVSERIAEAL 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039755706 728 GEVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDIKRQEKNHLDILCCVRG 802
Cdd:pfam12349 79 GEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIRV 153
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
581-1251 |
4.86e-59 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 222.83 E-value: 4.86e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 581 AWEKEFISFVKNY--KNPNLTISFTAERSIEDELNRESNSDVFTVIISYVVMFLYislalghiqSCSRLL----VDSKIS 654
Cdd:TIGR00918 358 AWQRNFSEEVQQSlpKNSSQKILVFSSTTLDDILKKFSDVSAIRIVSGYLLMLAY---------ACLTMLrwdcAKSQGS 428
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 655 LGIAGILIVLSSVACSLGIFSYMGMPLTLIVIEVIPFLVLAVGVDNIFILVQTYQrdERLQEETLDQQLGRILGEVAPTM 734
Cdd:TIGR00918 429 VGLAGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFS--ETGQNIPFEERTGECLKRTGASV 506
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 735 FLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDIKRQEKNHLDILCCV-------------- 800
Cdd:TIGR00918 507 VLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIFCCFfspcsarviqiepq 586
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 801 --------------------------RGAD-------------------------DGQGS-------------HASESYL 816
Cdd:TIGR00918 587 ayadgsappvysshmqstvqlrteydPGTQhyyttneprshlsvqpsdplscqspDIAGStrdllsqfedskaACLSLPC 666
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 817 FR-----FFKNYFAPLLLKDWLRPIVVAVFVGVLSFSVAVVNKVDIGLDQSLSMPNDSYVIDYFKSLAQYLhSGPPVYFV 891
Cdd:TIGR00918 667 ARwtlatFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTNEHDFLDAQFRYF-SFYNMYAV 745
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 892 LEEGYNYSSRKgqnmvcggmgcdndslvQQIFNAAelDTYTRV--------GFAPSSWIDDYFDWVSP-QSSCCRLYN-- 960
Cdd:TIGR00918 746 TQGNFDYPTQQ-----------------QLLYDLH--QSFSSVkyvlkednGQLPRMWLHYFRDWLQGlQKAFDEDWRdg 806
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 961 --VTHQFCNAS--------VMDPTCVRCRPLTPE--GKQRPQGKE-------FMKFLPMFLSDNPnpkcgkgghAAYG-S 1020
Cdd:TIGR00918 807 riTKENYRNGSddavlaykLLVQTGHRDKPVDKEqlTTQRLVNADgiinpnaFYIYLSAWVSNDP---------VAYAaS 877
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 1021 AVNI-------VGDDT-YIGATY------------FMTYHTILKTSADYTDAMKKARLIASNITetmrskGSDYRVFPYS 1080
Cdd:TIGR00918 878 QANIyphppewLHDKNdYDPENLripaaepleyaqFPFYLNGLRETSQFVEAIEHVRAICNNYE------GFGLPSYPSG 951
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 1081 VFYVFYEQYLTIIDDTIFNLSVSLGSIFLVTLVVLgCELWSAVIMCITIAMILVNMFGVMWLWGISLNAVSLVNLVMSCG 1160
Cdd:TIGR00918 952 YPFLFWEQYMGLRHWLLLSISVVLACTFLVCALLL-LNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIASVG 1030
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 1161 ISVEFCSHITRAFtMSTKGSRVSRAEEALAHMGSSVFSGITLTKFGgivVLAFAKSQI-FEIFYFRMYLAMV-LLGATHG 1238
Cdd:TIGR00918 1031 IGVEFTVHIALGF-LTAIGDRNRRAVLALEHMFAPVLDGALSTLLG---VLMLAGSEFdFIVRYFFAVLAVLtCLGVLNG 1106
|
810
....*....|...
gi 1039755706 1239 LIFLPVLLSYIGP 1251
Cdd:TIGR00918 1107 LVLLPVLLSMFGP 1119
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
335-1257 |
1.67e-34 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 142.69 E-value: 1.67e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 335 RRMFTKWGAFCVRNPTCIIFFSLAFITVCSSGLVFVQVTTNPVElWSAPHSQARLEKEYFDKHFGPffrTEQLIIqapnt 414
Cdd:COG1033 1 ERLMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFES-LLPEDDPSVQAYDEFEEEFGG---DDTVVV----- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 415 svhIYEPYPagaDVpfgppLNKEILHQVLDLQIAIESItasynnETVTlqdicvaplspynkncTIMSVLNyFQNSHAVL 494
Cdd:COG1033 72 ---AVEGKD---DI-----FTPETLEALRELTEELEEI------PGVD----------------SVTSLTN-VRATEGTE 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 495 DSQVGDDFyIYADYHThflycvrAPASLND--TSLLHGPclgtfggpvfpwlvlgGYDDQNYNN---ATALVITFPVNNY 569
Cdd:COG1033 118 DGLTVEPL-IPDELPA-------SPEELAElrEKVLSSP----------------LYVGRLVSPdgkATLIVVTLDPDPL 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 570 YNDTERLQRAwaweKEFISFVKNYKNPNLTISFTAERSIEDELNRESNSDVFTVI-ISYVVMFLYISLALGHIqscsrll 648
Cdd:COG1033 174 SSDLDRKEVV----AEIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFpLALLLILLLLFLFFRSL------- 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 649 vdskiSLGIAGILIVLSSVACSLGIFSYMGMPLTLIVIeVIPFLVLAVGVDNIFILVQTYqRDERLQEETLDQQLGRILG 728
Cdd:COG1033 243 -----RGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTI-LVPPLLLAIGIDYGIHLLNRY-REERRKGLDKREALREALR 315
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 729 EVAPTMFLSSFseTSAFFFGAL--SSMPAVHTFSLFAGMAVLIDFLLQITCFVSLL-GLDIKRqeknhldilccvrgadD 805
Cdd:COG1033 316 KLGPPVLLTSL--TTAIGFLSLlfSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLsLLPRPK----------------P 377
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 806 GQGSHASESYLFRFFKNyFAPLLLKdwLRPIVVAVFVGVLSFSVAVVNKVDIGLDQSLSMPNDSYVIDYFKSLAQYLHSG 885
Cdd:COG1033 378 KTRRLKKPPELGRLLAK-LARFVLR--RPKVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRQDLDFIEENFGGS 454
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 886 PPVYFVLEEGYNYssrkgqnmvcggmGCDNDSLVQQIFN-AAELDTYTRVGFAPSswIDDYFDWVSpqssccRLYNvthq 964
Cdd:COG1033 455 DPLEVVVDTGEPD-------------GLKDPEVLKEIDRlQDYLESLPEVGKVLS--LADLVKELN------QALN---- 509
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 965 fcnasvmdptcvrcrPLTPEGKQRPQGKEFMKFLPMFLSDNPnpkcgkgghaayGSAVN--IVGDDTYIGATYFMTYHti 1042
Cdd:COG1033 510 ---------------EGDPKYYALPESRELLAQLLLLLSSPP------------GDDLSrfVDEDYSAARVTVRLKDL-- 560
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 1043 lkTSADYTDAMKKARLIASNITETmrskgSDYRVFPYSVFYVFYEQYLTIIDDTIFNLSVSLGSIFLVTLVVLGcELWSA 1122
Cdd:COG1033 561 --DSEEIKALVEEVRAFLAENFPP-----DGVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAFR-SLRLG 632
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 1123 VIMCITIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFT--MSTKGSRVSRAEEALAHMGSSV-FSG 1199
Cdd:COG1033 633 LISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAIlFTS 712
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*....
gi 1039755706 1200 ITLtkFGGIVVLAFAKSQIfeIFYFRMYLAMVLLGATHG-LIFLPVLLSYIGPSVNKAK 1257
Cdd:COG1033 713 LTL--AAGFGVLLFSSFPP--LADFGLLLALGLLVALLAaLLLLPALLLLLDPRIAKKR 767
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
334-782 |
1.30e-12 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 72.59 E-value: 1.30e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 334 LRRMFTKWGAFCVRNPTCIIFFSLAFITVCSSGLVFVQVTTNPVElWSAPHSQARLEKEYFDKHFGPFfrteqliiqapn 413
Cdd:COG1033 388 LGRLLAKLARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFED-YLPEDSPIRQDLDFIEENFGGS------------ 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 414 TSVHIYepypagadVPFGPP---LNKEILHQVLDLQIAIESItasynnETVTlqdicvaplspynkncTIMSVLNYFQNS 490
Cdd:COG1033 455 DPLEVV--------VDTGEPdglKDPEVLKEIDRLQDYLESL------PEVG----------------KVLSLADLVKEL 504
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 491 HAVLDSQVGDDFYIyadyhthflycvraPASLNDTSLLHGPCLGTFGGpvfpwlVLGGYDDQNYNNAtalVITFPVNNyy 570
Cdd:COG1033 505 NQALNEGDPKYYAL--------------PESRELLAQLLLLLSSPPGD------DLSRFVDEDYSAA---RVTVRLKD-- 559
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 571 NDTERLQRAWAWEKEFISfvKNYKNPNLTISFTAERSIEDELNRE-SNSDVFTVIISYVVMFLYISLALGhiqscsrllv 649
Cdd:COG1033 560 LDSEEIKALVEEVRAFLA--ENFPPDGVEVTLTGSAVLFAAINESvIESQIRSLLLALLLIFLLLLLAFR---------- 627
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 650 dsKISLGIAGILIVLSSVACSLGIFSYMGMPLTLIVIEVIPfLVLAVGVDN-IFILvqTYQRDERLQEETLDQQLGRILG 728
Cdd:COG1033 628 --SLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVAS-IALGIGVDYtIHFL--SRYREERRKGGDLEEAIRRALR 702
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 1039755706 729 EVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVLIDFLLQITCFVSLL 782
Cdd:COG1033 703 TTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALL 756
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
1045-1261 |
3.01e-10 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 64.88 E-value: 3.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 1045 TSADYTDAMKKARliasNITETMRSKGSDYRVFpySVFYVFYEQYLTIIDDTIFNLSVSLGSIFLVTLVVLGCeLWSAVI 1124
Cdd:COG1033 175 SDLDRKEVVAEIR----AIIAKYEDPGVEVYLT--GFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRS-LRGVLL 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 1125 MCITIAMILVNMFGVMWLWGISLNAVS--LVNLVMscGISVEFCSHITRAFT--MSTKGSRVSRAEEALAHMGSSVFSGi 1200
Cdd:COG1033 248 PLLVVLLAVIWTLGLMGLLGIPLSPLTilVPPLLL--AIGIDYGIHLLNRYReeRRKGLDKREALREALRKLGPPVLLT- 324
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039755706 1201 TLTKFGGIVVLAFAKSQIFEIFYFRMYLAMVLLGATHgLIFLPVLLSYIGPSVNKAKRHTT 1261
Cdd:COG1033 325 SLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTS-LTLLPALLSLLPRPKPKTRRLKK 384
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
570-798 |
7.75e-08 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 56.77 E-value: 7.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 570 YNDTERlqrawawEKEFISFVKNYK---NPNLTISFTAERSIEDELNResnsdvfTVIISYVVMFLYIslalghiqscsr 646
Cdd:TIGR00921 157 YNDVER-------SLERTNPPSGKFldvTGSPAINYDIEREFGKDMGT-------TMAISGILVVLVL------------ 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 647 LLVDSKISLGIAGILIVLSSVACSLGIFSYMGMPLTLIVIEVIPfLVLAVGVDNIfILVQTYQRDERLQEETLDQQLGRI 726
Cdd:TIGR00921 211 LLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVP-MLIGVGIDYG-IQTLNRYEEERDIGRAKGEAIVTA 288
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039755706 727 LGEVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGL-DIKRQEKNHLDILC 798
Cdd:TIGR00921 289 VRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQSiDIGREKVKKEIIAI 361
|
|
| 2A060605 |
TIGR00920 |
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, ... |
610-791 |
1.15e-07 |
|
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273339 [Multi-domain] Cd Length: 886 Bit Score: 56.40 E-value: 1.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 610 DELNRESNS-DVFTVIISYVVMFLYIslalgHIQSCSRLLVDSKISLGIAGILIVLSSVACSLGIFSYMGMPLTLIViEV 688
Cdd:TIGR00920 51 PKFEEEYLSsDVIVMTITRCIAVLYI-----YYQFCNLRQLGSKYILGIAGLFTIFSSFVFSTAVIHFLGSELTGLN-EA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 689 IPFLVLAVGVDNIFILVQtYQRDERLQEETLDqQLGRILGEVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVL 768
Cdd:TIGR00920 125 LPFFLLLIDLSKASALAK-FALSSNSQDEVRD-NIARGMAILGPTITLDTVVETLVIGVGTMSGVRRLEVLCCFGCMSVL 202
|
170 180
....*....|....*....|....*.
gi 1039755706 769 IDFLLQITCF---VSLLgLDIKRQEK 791
Cdd:TIGR00920 203 ANYFVFMTFFpacLSLV-LELSRSGR 227
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
596-784 |
3.05e-07 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 54.84 E-value: 3.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 596 PNLTISFTAERSIEDELNRESNSDVFTVIISYVVMFLYISLAlghiqscsrllVDSKISLGIAGILIVLSSVACSLGIFS 675
Cdd:TIGR00921 545 PGVKVGVTGLPVAFAEMHELVNEGMRRMTIAGAILVLMILLA-----------VFRNPIKAVFPLIAIGSGILWAIGLMG 613
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 676 YMGMPLTLIVIEVIPfLVLAVGVDNIFILVQTY--QRDERLQEETLDQQLGRilgeVAPTMFLSSFseTSAFFFGAL--S 751
Cdd:TIGR00921 614 LRGIPSFLAMATTIS-IILGLGMDYSIHLAERYfeERKEHGPKEAITHTMER----TGPGILFSGL--TTAGGFLSLllS 686
|
170 180 190
....*....|....*....|....*....|...
gi 1039755706 752 SMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGL 784
Cdd:TIGR00921 687 HFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
1093-1276 |
5.89e-07 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 53.95 E-value: 5.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 1093 IDDTIFNLSVSLGSIFLVTLVVLGcELWSAVIMCITIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISV-------Ef 1165
Cdd:COG0841 330 IEEVVKTLLEAILLVVLVVFLFLR-SWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGIVVddaivvvE- 407
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 1166 csHITRafTMSTKGSRVSRAEEALAHMGSSVFSgITLTKfggIVV---LAFAKSQIFEIFYfrmYLAMVLLGAT-----H 1237
Cdd:COG0841 408 --NIER--HMEEGLSPLEAAIKGAREVAGAVIA-STLTL---VAVflpLAFMGGITGQLFR---QFALTVAIALlislfV 476
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1039755706 1238 GLIFLPVLLSYIGPSVNKAKRHTTYERY-RGTER-----ERLLNF 1276
Cdd:COG0841 477 ALTLTPALCARLLKPHPKGKKGRFFRAFnRGFDRltrgyGRLLRW 521
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
657-784 |
9.31e-07 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 52.29 E-value: 9.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 657 IAGILIVLS---SVACSLGI------FSYMGMPLTLIVIEVIpfLVLAVGVD-NIFiLVQTYqRDERLQEETLDQQLGRI 726
Cdd:pfam03176 167 VAALLPLLTvglSLGAAQGLvailahILGIGLSTFALNLLVV--LLIAVGTDyALF-LVSRY-REELRAGEDREEAVIRA 242
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 727 LGEVAPTMFLSSFseTSAFFFGAL--SSMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGL 784
Cdd:pfam03176 243 VRGTGKVVTAAGL--TVAIAMLALsfARLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
625-774 |
4.98e-05 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 47.92 E-value: 4.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 625 ISYVVMFLYISLALGhiqscsrllvdsKISLGIAGILIVLSSVACSLGIFSYMGMPLTLIVIeVIPFLVLAVGVD-NIFI 703
Cdd:COG4258 647 LALLLILLLLLLRLR------------SLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHL-IALLLVLGIGIDyALFF 713
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039755706 704 LVQTYQRDERLqeETLdqqlgrilgevaPTMFLSSFseTSAFFFG--ALSSMPAVHTFSLF----AGMAVLIDFLLQ 774
Cdd:COG4258 714 TEGLLDKGELA--RTL------------LSILLAAL--TTLLGFGllAFSSTPALRSFGLTvllgILLALLLAPLLA 774
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
1093-1213 |
5.01e-05 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 47.72 E-value: 5.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 1093 IDDTIFNLSVSL--GSIfLVTLVV---LGcELWSAVIMCITIAMILVNMFGVMWLWGISLNAVSLVNLVMSCG------- 1160
Cdd:COG3696 330 IDRAIHTVTKNLleGAL-LVILVLflfLG-NLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGLAIDFGiivdgav 407
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1039755706 1161 ISVEFC-SHITRAFTMSTKGSRVSRAEEALAHMGSSVFSGITltkfggIVVLAF 1213
Cdd:COG3696 408 VMVENIlRRLEENRAAGTPRERLEVVLEAAREVRRPIFFATL------IIILVF 455
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
1077-1249 |
5.12e-05 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 47.67 E-value: 5.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 1077 FPYSVFY-VFYEQYLTI---IDDTIFNLSVSLGSIFLVTLVVLGcELWSAVIMCITIAMILVNMFGVMWLWGISLNAVSL 1152
Cdd:pfam00873 310 FPQGVEIvVVYDTTPFIrasIEEVVKTLLEAIVLVILVMFLFLQ-NWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTL 388
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 1153 VNLVMSCGISV-------EFCSHITRAFTMSTKgsrvsraEEALAHMGSSVFSGItltkFGGIVVLAFaksqifeifyfr 1225
Cdd:pfam00873 389 GGLVLAIGLVVddaivvvENIERVLEENGLKPL-------EAAYKSMGEIGGALV----AIALVLSAV------------ 445
|
170 180
....*....|....*....|....
gi 1039755706 1226 mYLAMVLLGATHGLIFLPVLLSYI 1249
Cdd:pfam00873 446 -FLPILFLGGLTGRIFRQFAITIV 468
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
1085-1260 |
4.13e-04 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 44.84 E-value: 4.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 1085 FYEQYLtiiDDTIFNLSVSLGSIFLVTLVVLGcELWSAVIMCITIAMILVNMFGVMWLWGISLNAVSLVNLVMSCGISVE 1164
Cdd:COG4258 633 LFGRYR---NDALWLLLLALLLILLLLLLRLR-SLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGID 708
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 1165 FCSHITRAFTmstkgsrvsRAEEALAHMGSSVFSGI-TLTKFGgivVLAFAKSQIfeifyfrmyLA----MVLLGathgl 1239
Cdd:COG4258 709 YALFFTEGLL---------DKGELARTLLSILLAALtTLLGFG---LLAFSSTPA---------LRsfglTVLLG----- 762
|
170 180
....*....|....*....|.
gi 1039755706 1240 IFLPVLLSYIGPSVNKAKRHT 1260
Cdd:COG4258 763 ILLALLLAPLLAPRRRPRRAA 783
|
|
| RND_permease_2 |
NF033617 |
multidrug efflux RND transporter permease subunit; |
1084-1164 |
6.14e-04 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 411236 [Multi-domain] Cd Length: 1009 Bit Score: 44.24 E-value: 6.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 1084 VFYEQYLTI---IDDTIFNLSVSLGSIFLVTLVVLGcELWSAVIMCITIAMILVNMFGVMWLWGISLNAVSLVNLVMSCG 1160
Cdd:NF033617 317 VLYDRTRFIrasIDEVESTLLEAVALVILVVFLFLR-NLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIG 395
|
....
gi 1039755706 1161 ISVE 1164
Cdd:NF033617 396 LVVD 399
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
1098-1249 |
9.57e-04 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 43.67 E-value: 9.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755706 1098 FNLSVSLGSIFLVTLVVLGCELWSAVIMCITIAMILVNM-FGVMWLWGISLNAVSLVNLVMSCGISVEFCSHI-TRAFTM 1175
Cdd:TIGR00921 195 MGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWvLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTlNRYEEE 274
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039755706 1176 STKGSRVSRA-EEALAHMGSSVFSGITLTKFGgivVLAFAKSQIFEIFYFRMYLAM-VLLGATHGLIFLPVLLSYI 1249
Cdd:TIGR00921 275 RDIGRAKGEAiVTAVRRTGRAVLIALLTTSAG---FAALALSEFPMVSEFGLGLVAgLITAYLLTLLVLPALLQSI 347
|
|
| |
