NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1039752013|ref|XP_017172664|]
View 

mediator of RNA polymerase II transcription subunit 15 isoform X13 [Mus musculus]

Protein Classification

mediator complex subunit 15 domain-containing protein( domain architecture ID 707846)

mediator complex subunit 15 (MED15) domain-containing protein may be involved in bridging enhancers and promoters and most of the proteins bearing these domains are transcriptional coactivators

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Med15 super family cl26621
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 343-631 2.68e-118

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


The actual alignment was detected with superfamily member pfam09606:

Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 368.95  E-value: 2.68e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039752013 343 RTPQNFSvPSpGPLNTPVNpSSVMSPAGSSqaEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTD 422
Cdd:pfam09606 441 RTIGQDS-PG-GSLNTPGQ-SAVNSPLNPQ--EEQLYREKYRQLTKYIEPLKRMIAKMENDPGDIDKMNKMKRLLEILSN 515

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039752013 423 PSKRCPLKTLQKCEIALEklkNDMAVPtpppppvlptKQQDLCQPLLDAVLANIRSPVFNHSLYRTFVPAMMAIHGPPIV 502
Cdd:pfam09606 516 PSSRIPLETLQKCEAALE---NQMGTP----------REPPLNNPLLEAVLSNLQSPTGNHTLYRTFRPTLEALFGPDIK 582

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039752013 503 SPVVCSRKRRFEEDE---RQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQ 579
Cdd:pfam09606 583 GLPIPAKQPRLELDDttgRQEIPHILQGEIARLDQKFKVSLDPCAQSNNKTIKLICKLDDKNLPSVPPVAVSIPEDYPDQ 662

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1039752013 580 SPMWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQAC 631
Cdd:pfam09606 663 SPSCSLDEQEYNATPFLITVQKSLHARISKLPGLFSLSHLLDTWEMSVRQAC 714
Med15 super family cl26621
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 17-78 6.54e-19

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


The actual alignment was detected with superfamily member pfam09606:

Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 91.22  E-value: 6.54e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039752013  17 QKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASV 78
Cdd:pfam09606   1 QSVVNKIEEALQQNGQTSTKNAREMENHVFAKARTKDEYLGTVARLILHVRDMSKKAAQQQQ 62
 
Name Accession Description Interval E-value
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 343-631 2.68e-118

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 368.95  E-value: 2.68e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039752013 343 RTPQNFSvPSpGPLNTPVNpSSVMSPAGSSqaEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTD 422
Cdd:pfam09606 441 RTIGQDS-PG-GSLNTPGQ-SAVNSPLNPQ--EEQLYREKYRQLTKYIEPLKRMIAKMENDPGDIDKMNKMKRLLEILSN 515

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039752013 423 PSKRCPLKTLQKCEIALEklkNDMAVPtpppppvlptKQQDLCQPLLDAVLANIRSPVFNHSLYRTFVPAMMAIHGPPIV 502
Cdd:pfam09606 516 PSSRIPLETLQKCEAALE---NQMGTP----------REPPLNNPLLEAVLSNLQSPTGNHTLYRTFRPTLEALFGPDIK 582

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039752013 503 SPVVCSRKRRFEEDE---RQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQ 579
Cdd:pfam09606 583 GLPIPAKQPRLELDDttgRQEIPHILQGEIARLDQKFKVSLDPCAQSNNKTIKLICKLDDKNLPSVPPVAVSIPEDYPDQ 662

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1039752013 580 SPMWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQAC 631
Cdd:pfam09606 663 SPSCSLDEQEYNATPFLITVQKSLHARISKLPGLFSLSHLLDTWEMSVRQAC 714
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 17-78 6.54e-19

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 91.22  E-value: 6.54e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039752013  17 QKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASV 78
Cdd:pfam09606   1 QSVVNKIEEALQQNGQTSTKNAREMENHVFAKARTKDEYLGTVARLILHVRDMSKKAAQQQQ 62
 
Name Accession Description Interval E-value
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 343-631 2.68e-118

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 368.95  E-value: 2.68e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039752013 343 RTPQNFSvPSpGPLNTPVNpSSVMSPAGSSqaEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTD 422
Cdd:pfam09606 441 RTIGQDS-PG-GSLNTPGQ-SAVNSPLNPQ--EEQLYREKYRQLTKYIEPLKRMIAKMENDPGDIDKMNKMKRLLEILSN 515

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039752013 423 PSKRCPLKTLQKCEIALEklkNDMAVPtpppppvlptKQQDLCQPLLDAVLANIRSPVFNHSLYRTFVPAMMAIHGPPIV 502
Cdd:pfam09606 516 PSSRIPLETLQKCEAALE---NQMGTP----------REPPLNNPLLEAVLSNLQSPTGNHTLYRTFRPTLEALFGPDIK 582

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039752013 503 SPVVCSRKRRFEEDE---RQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQ 579
Cdd:pfam09606 583 GLPIPAKQPRLELDDttgRQEIPHILQGEIARLDQKFKVSLDPCAQSNNKTIKLICKLDDKNLPSVPPVAVSIPEDYPDQ 662

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1039752013 580 SPMWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQAC 631
Cdd:pfam09606 663 SPSCSLDEQEYNATPFLITVQKSLHARISKLPGLFSLSHLLDTWEMSVRQAC 714
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 17-78 6.54e-19

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 91.22  E-value: 6.54e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039752013  17 QKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASV 78
Cdd:pfam09606   1 QSVVNKIEEALQQNGQTSTKNAREMENHVFAKARTKDEYLGTVARLILHVRDMSKKAAQQQQ 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH