second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751665 311 IGTSLIQDMKAYLEGAGSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLRY 390
Cdd:cd18309     1 IGTTLEQDMEAFLESVGGDFCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMVPSRQAFDSLLRY 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1039751665 391 IYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQN 436
Cdd:cd18309    81 IYYGDVTMPPEDSLYLFSAPYFYGFTNNRLQAYCKQNLEMNVSFEN 126

first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a Golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039751665 239 DLQNVLVVCESAARLQLGQLKEHCLNFIVKESHFNQVIMMKEFERLSSPLIVEIVRRKQ 297
Cdd:cd18505     1 NVRNVLVALENASKLNLDQLKEHCLNFIVKESNYNQIVMSKEFEHLDQPLMVEIVRRRQ 59

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751665 311 IGTSLIQDMKAYLEGAGSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLRY 390
Cdd:cd18309     1 IGTTLEQDMEAFLESVGGDFCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMVPSRQAFDSLLRY 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1039751665 391 IYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQN 436
Cdd:cd18309    81 IYYGDVTMPPEDSLYLFSAPYFYGFTNNRLQAYCKQNLEMNVSFEN 126

first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a Golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039751665 239 DLQNVLVVCESAARLQLGQLKEHCLNFIVKESHFNQVIMMKEFERLSSPLIVEIVRRKQ 297
Cdd:cd18505     1 NVRNVLVALENASKLNLDQLKEHCLNFIVKESNYNQIVMSKEFEHLDQPLMVEIVRRRQ 59

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751665 329 EFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrqAFESMLRYIYYGEVnMPPEDSLYLFA 408
Cdd:pfam00651   9 ELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPE--DFEALLEFMYTGKL-ISEENVDDLLA 85

                          90       100
                  ....*....|....*....|
gi 1039751665 409 APYYYGFYnnRLQAYCKQNL 428
Cdd:pfam00651  86 AADKLQIP--SLVDKCEEFL 103

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751665  97 YGRLWEGRQFCDVEFVLGEKEecVQGHVAIVTARSRWLRRKivqaqewLAQKLEEDgalapkeapgpavgrarpPLLRVA 176
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKE--FRAHKAVLAACSPYFKAL-------FSGQESES------------------SVSEIT 53

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039751665 177 IREAEARPFEVLMQFLYTDKIKYPRKghvedvllIMDVYKLALSFQLCRLEQLCRQYIEAS 237
Cdd:pfam00651  54 LDDVSPEDFEALLEFMYTGKLISEEN--------VDDLLAAADKLQIPSLVDKCEEFLIKS 106

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751665 311 IGTSLIQDMKAYLEGAGSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLRY 390
Cdd:cd18309     1 IGTTLEQDMEAFLESVGGDFCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMVPSRQAFDSLLRY 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1039751665 391 IYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQN 436
Cdd:cd18309    81 IYYGDVTMPPEDSLYLFSAPYFYGFTNNRLQAYCKQNLEMNVSFEN 126

first BACK (BTB and C-terminal Kelch) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a Golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039751665 239 DLQNVLVVCESAARLQLGQLKEHCLNFIVKESHFNQVIMMKEFERLSSPLIVEIVRRKQ 297
Cdd:cd18505     1 NVRNVLVALENASKLNLDQLKEHCLNFIVKESNYNQIVMSKEFEHLDQPLMVEIVRRRQ 59

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751665 330 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEVNMPPEDSLYLFAA 409
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDV--SPEAFEALLDYIYTGELELSEENVEELLAA 78

                  ....
gi 1039751665 410 PYYY 413
Cdd:cd18186    79 ADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751665 309 VDIGTSLIQDMKAYLEGagSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEmvPSRQAFESML 388
Cdd:cd18287     3 IDHVHFLSEDIGALFLN--EEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKD--TNAEAFKALL 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1039751665 389 RYIYYGEVNM--PPEDSL--YLFAApYYYGFY 416
Cdd:cd18287    79 KYIYTGRLTLtdLKEDVLldVLGLA-HQYGFE 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751665 315 LIQDMKAYLEGagSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPsrQAFESMLRYIYYG 394
Cdd:cd18343     8 LAEDLGNLWEN--SRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDP--EVFKEMMRFIYTG 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1039751665 395 EVnmPPEDSLY--LFAAPYYYGFynNRLQAYCKQNLEMNVTVQN 436
Cdd:cd18343    84 KA--PNLDKMAdnLLAAADKYAL--ERLKVMCEEALCNNLSVEN 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751665 315 LIQDMKAYLEGagSEFCDITLLL--DGQPRPAHKAILAARSSYFEAMFRS-FMPEDGQVNISIGEMVPsrQAFESMLRYI 391
Cdd:cd18294     1 FAADMKSLINN--PEFSDVKFLVgpERQEIFAHKCILAARCEVFRAMFLTgPQKESTQSPLVLSDIEP--EVFRAVLEFI 76

                          90       100
                  ....*....|....*....|...
gi 1039751665 392 YYGEVNMPPEDSLYLFAAPYYYG 414
Cdd:cd18294    77 YTNCVTLSNHTVIEVLAAAVEYG 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751665 328 SEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEV---NMPPEDSL 404
Cdd:cd18297    10 PEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDI--RYDIFQLMMQYLYTGGVeslDVAQDDAL 87

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1039751665 405 YLFAAPYYYGFynNRLQAYCKQNLEMNVTVQN 436
Cdd:cd18297    88 ELLRAASFFQL--DGLKRHCEILLSQQIDLDN 117

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039751665 330 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVnISIGEmVPSRqAFESMLRYIYYGEVNMPPED 402
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEHPV-IILPD-VPYS-ELKALLDFIYTGEVNVSQEQ 70

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039751665 330 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLRYIYYGEVNMPPE 401
Cdd:cd18245    14 LCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQIKLSED 85

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751665 329 EFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEVNMPPE-DSLYLF 407
Cdd:cd18300     8 LFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGV--SKETFLALLEYLYTDQAPILEDgDCVGLI 85

                          90
                  ....*....|....*....
gi 1039751665 408 AAPYYYGFynNRLQAYCKQ 426
Cdd:cd18300    86 VLANRLCL--PRLVALCEQ 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039751665 331 CDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrqAFESMLRYIYYGEVNM 398
Cdd:cd18247    20 CDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPS--ALEALINFAYSGRIAI 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751665 330 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEVNMPPEDSLYLFAA 409
Cdd:cd18265    23 FTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKV--SAAAMEVLLDYMYGGGLRIQEDNVESVLEA 100

                          90       100
                  ....*....|....*....|....*....
gi 1039751665 410 PYYYGFynNRLQAYCKQNLEMNVTVQNVL 438
Cdd:cd18265   101 SDLLQV--SKLREACVRFLEGQLHPCNCL 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751665 314 SLIQDMKAYLegAGSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVN-ISIGEMVPSRQAFESMLRYIY 392
Cdd:cd18292     3 EFLQDIAQLY--NNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSeIELVEDPECAAVFEKFLRYLY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039751665 393 YGEVnmppedslylfaapyyygfynnrlqayckqnlemNVTVQNVLQILEAADKTQALDMKRHC 456
Cdd:cd18292    81 TGQI----------------------------------SVNLETALPLLMLADKYNVTDLKQLC 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751665 312 GTSLIQDMKAYLegAGSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYI 391
Cdd:cd18255     2 SVTLLQGLNALR--AKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGV--SAKGLKHILDFA 77

                  ....*
gi 1039751665 392 YYGEV 396
Cdd:cd18255    78 YTSEL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751665 328 SEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrqAFESMLRYIYYGEVNMPPEDSLYLF 407
Cdd:cd18342    20 SRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPE--VFKEMMCFIYTGKAPNLDKMADDLL 97

                          90       100
                  ....*....|....*....|....*....
gi 1039751665 408 AAPYYYGFynNRLQAYCKQNLEMNVTVQN 436
Cdd:cd18342    98 AAADKYAL--ERLKVMCEDALCSNLSVEN 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039751665 332 DITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEVNMPPEDSLYLF 407
Cdd:cd18298    14 DLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQY--SYPVYYAFLRYLYTDQVDLPPEDAIGLL 87

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751665 328 SEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPsrQAFESMLRYIYYGEVNMPPEDSLYLF 407
Cdd:cd18314     4 SEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEP--EIFETVLKYMYTGQVTLSEENVLDLL 81

                  ....*...
gi 1039751665 408 AAPYYYGF 415
Cdd:cd18314    82 MLASKYQV 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751665 329 EFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrqAFESMLRYIYYGEVNMPPEDSLYLFA 408
Cdd:cd18306    17 QFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPD--AVEVLVNYAYTSRLEVPADLVKSVYS 94

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1039751665 409 APYYYGFynNRLQAYCKQNLEMNVTVQNVLQI 440
Cdd:cd18306    95 AAKKLKM--DRVKKACGDFLLEKLTPQNCIGI 124

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039751665 328 SEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISiGEMVpSRQAFESMLRYIYYGEVNMPPED 402
Cdd:cd18295    17 GSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLK-HPLV-NPDAFRALLQYLYTGRLEIHVDD 89

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751665 332 DITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMvpSRQAFESMLRYIYYGEVNMPPEDSLYLFAAPY 411
Cdd:cd18352    15 DVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNI--RWEVFELMMRFIYTGSVDITNDIAKDLLRAAD 92

                          90       100
                  ....*....|....*....|....*.
gi 1039751665 412 YYGFYNnrLQAYCKQNLEMNVTVQNV 437
Cdd:cd18352    93 QYLLEG--LKRLCEYTIAQDLTLENI 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751665 329 EFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSrqAFESMLRYIYYGEVNMPPEDSLYLFA 408
Cdd:cd18237    20 TLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPD--IIELLVEFAYTARISVNSNNVQSLLD 97

                  ....*..
gi 1039751665 409 APYYYGF 415
Cdd:cd18237    98 AANQYQI 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751665  89 PKCTLHEDYGRLWEGRQFCDVEFVLGEKEecVQGHVAIVTARSrwlrrKIVQAQewLAQKLEEdgalAPKEapgpavgra 168
Cdd:cd18343     4 PECRLAEDLGNLWENSRFTDCSLFVGGQE--FKAHKSILAARS-----PVFNAM--FEHEMEE----SKKN--------- 61

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039751665 169 rppllRVAIREAEARPFEVLMQFLYTDKIkyPRKGHVEDVLLimdvyKLALSFQLCRLEQLCRQYIEASVDLQN 242
Cdd:cd18343    62 -----RVEINDVDPEVFKEMMRFIYTGKA--PNLDKMADNLL-----AAADKYALERLKVMCEEALCNNLSVEN 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751665 331 CDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIgeMVPSRQAFESMLRYIYYGEVNMPP---EDSLYlf 407
Cdd:cd18264    29 CDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHL--PVVSAAGLQRVLDFIYTSWLSLSLdtlEDTLE-- 104

                          90       100
                  ....*....|....*....|....*....
gi 1039751665 408 AAPYYYGFYNNRLqayCKQNLEMNVTVQN 436
Cdd:cd18264   105 AASYLQVTEAIGL---CSQYLINNLAPEN 130

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751665 330 FCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIgemvpSRQAFESMLRYIYYGEVNMPPEDSLYLFaa 409
Cdd:cd18290    27 YCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAV-----QPQSFQQILSFCYTGRLSMNVGDQFLLM-- 99