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Conserved domains on  [gi|1039728232|ref|XP_017175147|]
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hyccin 2 isoform X3 [Mus musculus]

Protein Classification

hyccin family protein( domain architecture ID 10561132)

hyccin family protein which may have a role in the beta-catenin-Tcf/Lef signaling pathway, as well as in the process of myelination of the central and peripheral nervous system; similar to human hycinn (also known as FAM126A) and FAM126B

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hyccin pfam09790
Hyccin; Members of this family of proteins may have a role in the beta-catenin-Tcf/Lef ...
 1-186 8.89e-86

Hyccin; Members of this family of proteins may have a role in the beta-catenin-Tcf/Lef signaling pathway, as well as in the process of myelination of the central and peripheral nervous system. Defects in Hyccin are the cause of hypomyelination with congenital cataracts [MIM:610532]. This disorder is characterized by congenital cataracts, progressive neurologic impairment, and diffuse myelin deficiency. Affected individuals experience progressive pyramidal and cerebellar dysfunction, muscle weakness and wasting prevailing in the lower limbs.


:

Pssm-ID: 462903  Cd Length: 323  Bit Score: 263.12  E-value: 8.89e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039728232   1 MALTEGAL--CQHDLIRVVYSDLHPQRETFTAQNRFEVLSFLMLCYNSAIVYMPASSYQSLCRMGSRVCVSGFPR----- 73
Cdd:pfam09790 125 SALTESALrrSEHGLTKTVKSGPHPQVETINAQNRFEVLTVLLFCYNEHISQMPKSSLLSLCRMTSRLCVCGFPRdtvfe 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039728232  74 ----QHEKQWKELCGRIVLDPEFMVQLLTGVYYAMYNGQWDLGQEVLDDIIYRAQLELFSQPLLVANAMKNSLPFDAPDS 149
Cdd:pfam09790 205 ssssQEVRGDSSISPRIPVSSEFLVELLRGLYFALYNGEWDLALQALDDIHYRAQYELYPEVLLVTNAIKNSLPLNAPGQ 284

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1039728232 150 SQEGQKVLKVEVTPTVPR--ISRTAITTASIRRHRWRRE 186
Cdd:pfam09790 285 SKEGPRGISVELTPTSSRtsISKSAITNASFRTKKLPDD 323
 
Name Accession Description Interval E-value
Hyccin pfam09790
Hyccin; Members of this family of proteins may have a role in the beta-catenin-Tcf/Lef ...
 1-186 8.89e-86

Hyccin; Members of this family of proteins may have a role in the beta-catenin-Tcf/Lef signaling pathway, as well as in the process of myelination of the central and peripheral nervous system. Defects in Hyccin are the cause of hypomyelination with congenital cataracts [MIM:610532]. This disorder is characterized by congenital cataracts, progressive neurologic impairment, and diffuse myelin deficiency. Affected individuals experience progressive pyramidal and cerebellar dysfunction, muscle weakness and wasting prevailing in the lower limbs.


Pssm-ID: 462903  Cd Length: 323  Bit Score: 263.12  E-value: 8.89e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039728232   1 MALTEGAL--CQHDLIRVVYSDLHPQRETFTAQNRFEVLSFLMLCYNSAIVYMPASSYQSLCRMGSRVCVSGFPR----- 73
Cdd:pfam09790 125 SALTESALrrSEHGLTKTVKSGPHPQVETINAQNRFEVLTVLLFCYNEHISQMPKSSLLSLCRMTSRLCVCGFPRdtvfe 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039728232  74 ----QHEKQWKELCGRIVLDPEFMVQLLTGVYYAMYNGQWDLGQEVLDDIIYRAQLELFSQPLLVANAMKNSLPFDAPDS 149
Cdd:pfam09790 205 ssssQEVRGDSSISPRIPVSSEFLVELLRGLYFALYNGEWDLALQALDDIHYRAQYELYPEVLLVTNAIKNSLPLNAPGQ 284

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1039728232 150 SQEGQKVLKVEVTPTVPR--ISRTAITTASIRRHRWRRE 186
Cdd:pfam09790 285 SKEGPRGISVELTPTSSRtsISKSAITNASFRTKKLPDD 323
 
Name Accession Description Interval E-value
Hyccin pfam09790
Hyccin; Members of this family of proteins may have a role in the beta-catenin-Tcf/Lef ...
 1-186 8.89e-86

Hyccin; Members of this family of proteins may have a role in the beta-catenin-Tcf/Lef signaling pathway, as well as in the process of myelination of the central and peripheral nervous system. Defects in Hyccin are the cause of hypomyelination with congenital cataracts [MIM:610532]. This disorder is characterized by congenital cataracts, progressive neurologic impairment, and diffuse myelin deficiency. Affected individuals experience progressive pyramidal and cerebellar dysfunction, muscle weakness and wasting prevailing in the lower limbs.


Pssm-ID: 462903  Cd Length: 323  Bit Score: 263.12  E-value: 8.89e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039728232   1 MALTEGAL--CQHDLIRVVYSDLHPQRETFTAQNRFEVLSFLMLCYNSAIVYMPASSYQSLCRMGSRVCVSGFPR----- 73
Cdd:pfam09790 125 SALTESALrrSEHGLTKTVKSGPHPQVETINAQNRFEVLTVLLFCYNEHISQMPKSSLLSLCRMTSRLCVCGFPRdtvfe 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039728232  74 ----QHEKQWKELCGRIVLDPEFMVQLLTGVYYAMYNGQWDLGQEVLDDIIYRAQLELFSQPLLVANAMKNSLPFDAPDS 149
Cdd:pfam09790 205 ssssQEVRGDSSISPRIPVSSEFLVELLRGLYFALYNGEWDLALQALDDIHYRAQYELYPEVLLVTNAIKNSLPLNAPGQ 284

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1039728232 150 SQEGQKVLKVEVTPTVPR--ISRTAITTASIRRHRWRRE 186
Cdd:pfam09790 285 SKEGPRGISVELTPTSSRtsISKSAITNASFRTKKLPDD 323
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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