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Conserved domains on  [gi|1039001841|emb|SBT28078|]
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transcriptional activator [Saccharomyces uvarum x Saccharomyces eubayanus]

Protein Classification

Zn(II)2Cys6 transcription factor( domain architecture ID 11086767)

Zn(II)2Cys6 transcription factor domain-containing proteins form a subclass of zinc finger proteins found exclusively in fungi

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 235-647 2.12e-49

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


:

Pssm-ID: 213391  Cd Length: 410  Bit Score: 180.33  E-value: 2.12e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039001841 235 SRSTTSRFIQSYLDNFHPYCPIVHSQTLMMLYNNQIEIASKD--QWQILFNSVLSIGAWCVEGESTDIDL------FYYQ 306
Cdd:cd12148     2 PREVADRLLDLYFENVHPLFPILHRPTFLRDLESLYSDPSSLspASLALLLAVLALAALSLPDSELRGESrrslaeRYYE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039001841 307 NAKSHLTSKVFEAGSITLVIALHLLSRYTQWRQRPNTSYSYHGFSMRMAISLGLNKDLPSSFNDTSI-LEQRRRIWWSLY 385
Cdd:cd12148    82 AARQLLDLALFLPPSLETLQALLLLALYLLGTGDPSSAWLLLGLAIRLAQSLGLHRDPSSLPGLSPFeRELRRRLWWSLY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039001841 386 NWEFHLTLLYGRSMQFSASSTqnSISLPSSVDD--------MQRTTTHPTIYHGTIETARLLQNFTKICELDKTTTTTKS 457
Cdd:cd12148   162 ILDRLLSLSLGRPPSISDEDI--DVPLPSNEDDelspssspPPPPSEEPTSLSFFIALIRLARILGRILRLLYSPRASSP 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039001841 458 PISAKRCLIICNEIEDVSRQIPKFLQMDISSTaltnllnEHPWLSFTRFQLRWKQLSLIIYVLRGFFAnlnsqqESRSRQ 537
Cdd:cd12148   240 EDSLETILELDAELEEWRASLPPELRLDSSSL-------ESPSLLPQRLLLHLLYHLLLILLHRPFLL------RSLSSL 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039001841 538 DQNHHSSYEVERCsillHDAAqRTIMSINNYMDNHTLTPYFASICVFYLFSAALVpvttLLSNTGSNSNSSDTSQSIQQI 617
Cdd:cd12148   307 SPSSSSAESRRAC----LEAA-REILELLRLLLSSSLLLLLWWFLLYYLFSAALV----LLLALLLRPSSSELEEARSLL 377

                         410       420       430
                  ....*....|....*....|....*....|
gi 1039001841 618 STALLLLKNLITFKIPTCEKYIQVLEQVCA 647
Cdd:cd12148   378 ERALELLERLSERWPRLARRALRLLERLLA 407
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
9-47 1.04e-15

Fungal Zn(2)-Cys(6) binuclear cluster domain;


:

Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 71.56  E-value: 1.04e-15
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1039001841   9 QACDICRLKKLKCSKEKPKCSKCLKNNWECCYSPKTKRS 47
Cdd:pfam00172   1 TACDNCRKRKVKCDGKKPACSRCIKNGLECTYSRKSKKS 39
ZIP_Gal4 cd14654
Leucine zipper Dimerization domain of transcription factor Gal4 and similar fungal proteins; ...
 50-85 3.74e-11

Leucine zipper Dimerization domain of transcription factor Gal4 and similar fungal proteins; Gal4p is one of several GAL proteins required for the growth of yeast on galactose; GAL proteins are responsible for the transport of galactose into the cell and for its metabolism through the glycolytic pathway. Gal4p functions in the induction of GAL genes in the presence of galactose through an upstream activating sequence (UAS) present in their promoters. The Gal4p family of transcriptional activators contain an N-terminal DNA binding domain with a Zn2Cys6 binuclear cluster that interact with CCG triplets and a leucine zipper-like heptad repeat that dimerizes. Dimerization allows binding of targets which contain two CCG motifs oriented in an inverted (CGG-CCG), direct (CCG-CCG), or everted (CCG-CGG) manner.


:

Pssm-ID: 271238  Cd Length: 47  Bit Score: 58.77  E-value: 3.74e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1039001841  50 TRVHLTEVESRLEKLEQLFLLMFPRENLDHVLKMDS 85
Cdd:cd14654     1 TRAHLTEVENRLEKLEALLRQLLPGVDIDELLESPS 36
 
Name Accession Description Interval E-value
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 235-647 2.12e-49

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


Pssm-ID: 213391  Cd Length: 410  Bit Score: 180.33  E-value: 2.12e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039001841 235 SRSTTSRFIQSYLDNFHPYCPIVHSQTLMMLYNNQIEIASKD--QWQILFNSVLSIGAWCVEGESTDIDL------FYYQ 306
Cdd:cd12148     2 PREVADRLLDLYFENVHPLFPILHRPTFLRDLESLYSDPSSLspASLALLLAVLALAALSLPDSELRGESrrslaeRYYE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039001841 307 NAKSHLTSKVFEAGSITLVIALHLLSRYTQWRQRPNTSYSYHGFSMRMAISLGLNKDLPSSFNDTSI-LEQRRRIWWSLY 385
Cdd:cd12148    82 AARQLLDLALFLPPSLETLQALLLLALYLLGTGDPSSAWLLLGLAIRLAQSLGLHRDPSSLPGLSPFeRELRRRLWWSLY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039001841 386 NWEFHLTLLYGRSMQFSASSTqnSISLPSSVDD--------MQRTTTHPTIYHGTIETARLLQNFTKICELDKTTTTTKS 457
Cdd:cd12148   162 ILDRLLSLSLGRPPSISDEDI--DVPLPSNEDDelspssspPPPPSEEPTSLSFFIALIRLARILGRILRLLYSPRASSP 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039001841 458 PISAKRCLIICNEIEDVSRQIPKFLQMDISSTaltnllnEHPWLSFTRFQLRWKQLSLIIYVLRGFFAnlnsqqESRSRQ 537
Cdd:cd12148   240 EDSLETILELDAELEEWRASLPPELRLDSSSL-------ESPSLLPQRLLLHLLYHLLLILLHRPFLL------RSLSSL 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039001841 538 DQNHHSSYEVERCsillHDAAqRTIMSINNYMDNHTLTPYFASICVFYLFSAALVpvttLLSNTGSNSNSSDTSQSIQQI 617
Cdd:cd12148   307 SPSSSSAESRRAC----LEAA-REILELLRLLLSSSLLLLLWWFLLYYLFSAALV----LLLALLLRPSSSELEEARSLL 377

                         410       420       430
                  ....*....|....*....|....*....|
gi 1039001841 618 STALLLLKNLITFKIPTCEKYIQVLEQVCA 647
Cdd:cd12148   378 ERALELLERLSERWPRLARRALRLLERLLA 407
Fungal_trans pfam04082
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 243-420 1.28e-18

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and nicotinate catabolism cluster-specific transcription factor HxnR.


Pssm-ID: 397964  Cd Length: 262  Bit Score: 86.78  E-value: 1.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039001841 243 IQSYLDNFHPYCPIVHSQTLMMLYNNQIEIASKDQWQILFNSVLSIGA--------WCVEGESTDIDLFYYQNAKSH--- 311
Cdd:pfam04082   1 LDLFFKNFHPQFPILHRPSFLRDYFELFSSPSNYASPLLLLAILALGAlfsesptaRSSSSLTDEAADGIHFFLRALili 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039001841 312 LTSKVFEAGSITLVIALHLLSRYTQWRQRPNTSYSYHGFSMRMAISLGLNKDlPSSFNDTSIL-----EQRRRIWWSLYN 386
Cdd:pfam04082  81 HEDFSSPSSSLWILQALLLLELYELGTGDRKLHWRYHGLAIRLARSLGLHRD-PSYVSPSWKLwieeaELRRRLFWACFY 159

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1039001841 387 WEFHLTLLYGRSMQFSASSTQnsISLPSSVDDMQ 420
Cdd:pfam04082 160 LDRLISLILGRPPLLSDSDID--LPLPCDDDDLW 191
Fungal_trans smart00906
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 321-418 7.23e-16

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and other transcription proteins regulating a variety of cellular and metabolic processes.


Pssm-ID: 214903 [Multi-domain]  Cd Length: 93  Bit Score: 73.64  E-value: 7.23e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039001841  321 SITLVIALhLLSRYTQWRQRPNTSYSYHGFSMRMAISLGLNKDlpSSFNDTSILEQRRRIWWSLYNWEFHLTLLYGRSMQ 400
Cdd:smart00906   1 SLETVQAL-LLALLSLYLGGRDAAWMLLGLAIRLAQALGLHRD--PSNSDLEERERRRRRFWWLYILDRLLSLSLGRPPL 77

                           90
                   ....*....|....*...
gi 1039001841  401 FSASSTqnSISLPSSVDD 418
Cdd:smart00906  78 IDDDDI--DVPLPSDLDD 93
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
9-47 1.04e-15

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 71.56  E-value: 1.04e-15
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1039001841   9 QACDICRLKKLKCSKEKPKCSKCLKNNWECCYSPKTKRS 47
Cdd:pfam00172   1 TACDNCRKRKVKCDGKKPACSRCIKNGLECTYSRKSKKS 39
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 9-47 4.67e-14

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 67.00  E-value: 4.67e-14
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1039001841    9 QACDICRLKKLKCSKEKPKCSKCLKNNWECCYSPKTKRS 47
Cdd:smart00066   5 KACDRCRKRKIKCDGKKPPCSNCIKLGLECTYSDSKKRK 43
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 9-41 3.27e-12

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 61.53  E-value: 3.27e-12
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1039001841   9 QACDICRLKKLKCSKEKPKCSKCLKNNWECCYS 41
Cdd:cd00067     4 RACDRCRRRKIKCDGEKPPCSNCIKLGLECTYS 36
ZIP_Gal4 cd14654
Leucine zipper Dimerization domain of transcription factor Gal4 and similar fungal proteins; ...
 50-85 3.74e-11

Leucine zipper Dimerization domain of transcription factor Gal4 and similar fungal proteins; Gal4p is one of several GAL proteins required for the growth of yeast on galactose; GAL proteins are responsible for the transport of galactose into the cell and for its metabolism through the glycolytic pathway. Gal4p functions in the induction of GAL genes in the presence of galactose through an upstream activating sequence (UAS) present in their promoters. The Gal4p family of transcriptional activators contain an N-terminal DNA binding domain with a Zn2Cys6 binuclear cluster that interact with CCG triplets and a leucine zipper-like heptad repeat that dimerizes. Dimerization allows binding of targets which contain two CCG motifs oriented in an inverted (CGG-CCG), direct (CCG-CCG), or everted (CCG-CGG) manner.


Pssm-ID: 271238  Cd Length: 47  Bit Score: 58.77  E-value: 3.74e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1039001841  50 TRVHLTEVESRLEKLEQLFLLMFPRENLDHVLKMDS 85
Cdd:cd14654     1 TRAHLTEVENRLEKLEALLRQLLPGVDIDELLESPS 36
Gal4_dimer pfam03902
Gal4-like dimerization domain;
50-82 8.12e-06

Gal4-like dimerization domain;


Pssm-ID: 397816  Cd Length: 44  Bit Score: 43.59  E-value: 8.12e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1039001841  50 TRVHLTEVESRLEKLEQLFLLMFPRENLDHVLK 82
Cdd:pfam03902   1 TRAHLTEVENRVTQLEQILRRLLPDEDIDNLLE 33
 
Name Accession Description Interval E-value
fungal_TF_MHR cd12148
fungal transcription factor regulatory middle homology region; This domain is present in the ...
 235-647 2.12e-49

fungal transcription factor regulatory middle homology region; This domain is present in the large family of fungal zinc cluster transcription factors that contain an N-terminal GAL4-like C6 zinc binuclear cluster DNA-binding domain. Examples of members of this large fungal group are the following Saccharomyces cerevisiae transcription factors, GAL4, STB5, DAL81, CAT8, RDR1, HAL9, PUT3, PPR1, ASG1, RSF2, PIP2, as well as the C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3. It has been suggested that this region plays a regulatory role.


Pssm-ID: 213391  Cd Length: 410  Bit Score: 180.33  E-value: 2.12e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039001841 235 SRSTTSRFIQSYLDNFHPYCPIVHSQTLMMLYNNQIEIASKD--QWQILFNSVLSIGAWCVEGESTDIDL------FYYQ 306
Cdd:cd12148     2 PREVADRLLDLYFENVHPLFPILHRPTFLRDLESLYSDPSSLspASLALLLAVLALAALSLPDSELRGESrrslaeRYYE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039001841 307 NAKSHLTSKVFEAGSITLVIALHLLSRYTQWRQRPNTSYSYHGFSMRMAISLGLNKDLPSSFNDTSI-LEQRRRIWWSLY 385
Cdd:cd12148    82 AARQLLDLALFLPPSLETLQALLLLALYLLGTGDPSSAWLLLGLAIRLAQSLGLHRDPSSLPGLSPFeRELRRRLWWSLY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039001841 386 NWEFHLTLLYGRSMQFSASSTqnSISLPSSVDD--------MQRTTTHPTIYHGTIETARLLQNFTKICELDKTTTTTKS 457
Cdd:cd12148   162 ILDRLLSLSLGRPPSISDEDI--DVPLPSNEDDelspssspPPPPSEEPTSLSFFIALIRLARILGRILRLLYSPRASSP 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039001841 458 PISAKRCLIICNEIEDVSRQIPKFLQMDISSTaltnllnEHPWLSFTRFQLRWKQLSLIIYVLRGFFAnlnsqqESRSRQ 537
Cdd:cd12148   240 EDSLETILELDAELEEWRASLPPELRLDSSSL-------ESPSLLPQRLLLHLLYHLLLILLHRPFLL------RSLSSL 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039001841 538 DQNHHSSYEVERCsillHDAAqRTIMSINNYMDNHTLTPYFASICVFYLFSAALVpvttLLSNTGSNSNSSDTSQSIQQI 617
Cdd:cd12148   307 SPSSSSAESRRAC----LEAA-REILELLRLLLSSSLLLLLWWFLLYYLFSAALV----LLLALLLRPSSSELEEARSLL 377

                         410       420       430
                  ....*....|....*....|....*....|
gi 1039001841 618 STALLLLKNLITFKIPTCEKYIQVLEQVCA 647
Cdd:cd12148   378 ERALELLERLSERWPRLARRALRLLERLLA 407
Fungal_trans pfam04082
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 243-420 1.28e-18

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and nicotinate catabolism cluster-specific transcription factor HxnR.


Pssm-ID: 397964  Cd Length: 262  Bit Score: 86.78  E-value: 1.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039001841 243 IQSYLDNFHPYCPIVHSQTLMMLYNNQIEIASKDQWQILFNSVLSIGA--------WCVEGESTDIDLFYYQNAKSH--- 311
Cdd:pfam04082   1 LDLFFKNFHPQFPILHRPSFLRDYFELFSSPSNYASPLLLLAILALGAlfsesptaRSSSSLTDEAADGIHFFLRALili 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039001841 312 LTSKVFEAGSITLVIALHLLSRYTQWRQRPNTSYSYHGFSMRMAISLGLNKDlPSSFNDTSIL-----EQRRRIWWSLYN 386
Cdd:pfam04082  81 HEDFSSPSSSLWILQALLLLELYELGTGDRKLHWRYHGLAIRLARSLGLHRD-PSYVSPSWKLwieeaELRRRLFWACFY 159

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1039001841 387 WEFHLTLLYGRSMQFSASSTQnsISLPSSVDDMQ 420
Cdd:pfam04082 160 LDRLISLILGRPPLLSDSDID--LPLPCDDDDLW 191
Fungal_trans smart00906
Fungal specific transcription factor domain; This domain is found in a number of fungal ...
 321-418 7.23e-16

Fungal specific transcription factor domain; This domain is found in a number of fungal transcription factors including transcriptional activator xlnR, yeast regulatory protein GAL4, and other transcription proteins regulating a variety of cellular and metabolic processes.


Pssm-ID: 214903 [Multi-domain]  Cd Length: 93  Bit Score: 73.64  E-value: 7.23e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039001841  321 SITLVIALhLLSRYTQWRQRPNTSYSYHGFSMRMAISLGLNKDlpSSFNDTSILEQRRRIWWSLYNWEFHLTLLYGRSMQ 400
Cdd:smart00906   1 SLETVQAL-LLALLSLYLGGRDAAWMLLGLAIRLAQALGLHRD--PSNSDLEERERRRRRFWWLYILDRLLSLSLGRPPL 77

                           90
                   ....*....|....*...
gi 1039001841  401 FSASSTqnSISLPSSVDD 418
Cdd:smart00906  78 IDDDDI--DVPLPSDLDD 93
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
9-47 1.04e-15

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 71.56  E-value: 1.04e-15
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1039001841   9 QACDICRLKKLKCSKEKPKCSKCLKNNWECCYSPKTKRS 47
Cdd:pfam00172   1 TACDNCRKRKVKCDGKKPACSRCIKNGLECTYSRKSKKS 39
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 9-47 4.67e-14

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 67.00  E-value: 4.67e-14
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1039001841    9 QACDICRLKKLKCSKEKPKCSKCLKNNWECCYSPKTKRS 47
Cdd:smart00066   5 KACDRCRKRKIKCDGKKPPCSNCIKLGLECTYSDSKKRK 43
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 9-41 3.27e-12

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 61.53  E-value: 3.27e-12
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1039001841   9 QACDICRLKKLKCSKEKPKCSKCLKNNWECCYS 41
Cdd:cd00067     4 RACDRCRRRKIKCDGEKPPCSNCIKLGLECTYS 36
ZIP_Gal4 cd14654
Leucine zipper Dimerization domain of transcription factor Gal4 and similar fungal proteins; ...
 50-85 3.74e-11

Leucine zipper Dimerization domain of transcription factor Gal4 and similar fungal proteins; Gal4p is one of several GAL proteins required for the growth of yeast on galactose; GAL proteins are responsible for the transport of galactose into the cell and for its metabolism through the glycolytic pathway. Gal4p functions in the induction of GAL genes in the presence of galactose through an upstream activating sequence (UAS) present in their promoters. The Gal4p family of transcriptional activators contain an N-terminal DNA binding domain with a Zn2Cys6 binuclear cluster that interact with CCG triplets and a leucine zipper-like heptad repeat that dimerizes. Dimerization allows binding of targets which contain two CCG motifs oriented in an inverted (CGG-CCG), direct (CCG-CCG), or everted (CCG-CGG) manner.


Pssm-ID: 271238  Cd Length: 47  Bit Score: 58.77  E-value: 3.74e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1039001841  50 TRVHLTEVESRLEKLEQLFLLMFPRENLDHVLKMDS 85
Cdd:cd14654     1 TRAHLTEVENRLEKLEALLRQLLPGVDIDELLESPS 36
Gal4_dimer pfam03902
Gal4-like dimerization domain;
50-82 8.12e-06

Gal4-like dimerization domain;


Pssm-ID: 397816  Cd Length: 44  Bit Score: 43.59  E-value: 8.12e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1039001841  50 TRVHLTEVESRLEKLEQLFLLMFPRENLDHVLK 82
Cdd:pfam03902   1 TRAHLTEVENRVTQLEQILRRLLPDEDIDNLLE 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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