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Conserved domains on  [gi|1036422517|gb|ANK14149|]
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dehydrogenase [Erythrobacter neustonensis]

Protein Classification

methanol/ethanol family PQQ-dependent dehydrogenase( domain architecture ID 10178893)

methanol/ethanol family PQQ-dependent dehydrogenase similar to Thauera butanivorans 1-butanol dehydrogenase (quinone) that catalyzes the oxidation of 1-butanol to 1-butanal and may function primarily in energy generation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PQQ_ADH_I cd10277
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); ...
 34-579 0e+00

Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); This bacterial family of homodimeric ethanol dehydrogenases utilize pyrroloquinoline quinone (PQQ) as a cofactor. It represents proteins whose expression may be induced by ethanol, and which are similar to quinoprotein methanol dehydrogenases, but have higher specificities for ethanol and other primary and secondary alcohols. Dehydrogenases with PQQ cofactors, such as ethanol, methanol, and membrane-bound glucose dehydrogenases, form an 8-bladed beta-propeller.


:

Pssm-ID: 199835 [Multi-domain]  Cd Length: 529  Bit Score: 885.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  34 LMNDAATTGDVLTYGIGPQQQRFSPLAAINTENVARMVPAFAASLGGeKQRGQESQPIVYDGVIYVTGSYSRLFAFDARN 113
Cdd:cd10277     1 LLNDAKETGNWLTYGRGYNGQRYSPLKQINTDNVKNLVPAWSFSFGG-KQRGQESQPIVNDGVMYVTTSYNRVFAIDAKT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 114 GEKLWEYNHRLPDGIMPCCDVVNRGAAIHGDKVIFATLDARLVALNRKTGKVIWNKMTADYKAGYSATAAPIIVKNLVIT 193
Cdd:cd10277    80 GKELWKYKHRLPEDIRPCCDVVNRGVALYGDKVYFGTLDAHLVALDAKTGKVVWKKKVADYKAGYSMTLAPLVVKGKVIV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 194 GNSGGEFGAVGEVQARNVDTGELVWTRPVIEGHMGTLNGKdngltgkinaTWQGDMWKTGGGATWLGGTYDPDTNLVFFG 273
Cdd:cd10277   160 GVSGGEFGVRGFIAALDAETGKEVWRTYTVPGPGEPGSTD----------TWPGDAWKTGGGATWLTGTYDPETNLLYWG 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 274 TGNPAPWNSHLRPGDNLYTASTVAIDPDTGVIKWHYQTTPNDGWDFDGVNEFIPFDGTFGGKKMKLGAKADRNGYFYVLD 353
Cdd:cd10277   230 VGNPAPWNGDLRPGDNLYTSSVLALDPDTGKIKWHYQYTPNDTWDYDGVNEPVLFDYTKNGKPVKALVHADRNGFFYVLD 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 354 RTNGRLLNATPFVMQPNWASkIDLKTGRPVYNAENRPGapgtaEKGKPVFATPSFLGGKNWMPMAYSPDTEMFYVPSNDW 433
Cdd:cd10277   310 RTNGKLIWATPFVKKITWAS-IDLKTGRPIYDEDKVPP-----KKGKTVDFCPSFLGGKNWPPMAYSPDTGLFYVPANHW 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 434 GMDIWNEPIAYKKGAAYLGAGFTIKPIAEDHIGALRAVDPKTGKIMWEYKNKAPLWGGVLTTRGNLVFTGTPEGYLKAFD 513
Cdd:cd10277   384 CMDLTGEPVSYKKGAAYLGAGFTIKPPFEDHIGELQAIDPTTGKKVWEHKTPLPLWGGVLTTAGGLVFTGTPDGYFRAFD 463

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1036422517 514 AKTGKELWKFQTGSGVVGSPVTWEQDGEQYVAVMSGWGGAVPLWGGEVAKTFKEISQGGSLWVFKL 579
Cdd:cd10277   464 AKTGKELWEFQTGSGIIGPPVTWEVDGKQYVAVLSGWGGAAPLWGGDMAKLLKNVPQGGSLWVFAL 529
 
Name Accession Description Interval E-value
PQQ_ADH_I cd10277
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); ...
 34-579 0e+00

Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); This bacterial family of homodimeric ethanol dehydrogenases utilize pyrroloquinoline quinone (PQQ) as a cofactor. It represents proteins whose expression may be induced by ethanol, and which are similar to quinoprotein methanol dehydrogenases, but have higher specificities for ethanol and other primary and secondary alcohols. Dehydrogenases with PQQ cofactors, such as ethanol, methanol, and membrane-bound glucose dehydrogenases, form an 8-bladed beta-propeller.


Pssm-ID: 199835 [Multi-domain]  Cd Length: 529  Bit Score: 885.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  34 LMNDAATTGDVLTYGIGPQQQRFSPLAAINTENVARMVPAFAASLGGeKQRGQESQPIVYDGVIYVTGSYSRLFAFDARN 113
Cdd:cd10277     1 LLNDAKETGNWLTYGRGYNGQRYSPLKQINTDNVKNLVPAWSFSFGG-KQRGQESQPIVNDGVMYVTTSYNRVFAIDAKT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 114 GEKLWEYNHRLPDGIMPCCDVVNRGAAIHGDKVIFATLDARLVALNRKTGKVIWNKMTADYKAGYSATAAPIIVKNLVIT 193
Cdd:cd10277    80 GKELWKYKHRLPEDIRPCCDVVNRGVALYGDKVYFGTLDAHLVALDAKTGKVVWKKKVADYKAGYSMTLAPLVVKGKVIV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 194 GNSGGEFGAVGEVQARNVDTGELVWTRPVIEGHMGTLNGKdngltgkinaTWQGDMWKTGGGATWLGGTYDPDTNLVFFG 273
Cdd:cd10277   160 GVSGGEFGVRGFIAALDAETGKEVWRTYTVPGPGEPGSTD----------TWPGDAWKTGGGATWLTGTYDPETNLLYWG 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 274 TGNPAPWNSHLRPGDNLYTASTVAIDPDTGVIKWHYQTTPNDGWDFDGVNEFIPFDGTFGGKKMKLGAKADRNGYFYVLD 353
Cdd:cd10277   230 VGNPAPWNGDLRPGDNLYTSSVLALDPDTGKIKWHYQYTPNDTWDYDGVNEPVLFDYTKNGKPVKALVHADRNGFFYVLD 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 354 RTNGRLLNATPFVMQPNWASkIDLKTGRPVYNAENRPGapgtaEKGKPVFATPSFLGGKNWMPMAYSPDTEMFYVPSNDW 433
Cdd:cd10277   310 RTNGKLIWATPFVKKITWAS-IDLKTGRPIYDEDKVPP-----KKGKTVDFCPSFLGGKNWPPMAYSPDTGLFYVPANHW 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 434 GMDIWNEPIAYKKGAAYLGAGFTIKPIAEDHIGALRAVDPKTGKIMWEYKNKAPLWGGVLTTRGNLVFTGTPEGYLKAFD 513
Cdd:cd10277   384 CMDLTGEPVSYKKGAAYLGAGFTIKPPFEDHIGELQAIDPTTGKKVWEHKTPLPLWGGVLTTAGGLVFTGTPDGYFRAFD 463

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1036422517 514 AKTGKELWKFQTGSGVVGSPVTWEQDGEQYVAVMSGWGGAVPLWGGEVAKTFKEISQGGSLWVFKL 579
Cdd:cd10277   464 AKTGKELWEFQTGSGIIGPPVTWEVDGKQYVAVLSGWGGAAPLWGGDMAKLLKNVPQGGSLWVFAL 529
PQQ_enz_alc_DH TIGR03075
PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic ...
 32-552 0e+00

PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Genes in this family often are found adjacent to the PQQ biosynthesis genes themselves. An unusual, strained disulfide bond between adjacent Cys residues contributes to PQQ-binding, as does a Trp residue that is part of a PQQ enzyme repeat (see pfam01011). Characterized members include the dehydrogenase subunit of a membrane-anchored, three subunit alcohol (ethanol) dehydrogenase of Gluconobacter suboxydans, a homodimeric ethanol dehydrogenase in Pseudomonas aeruginosa, and the large subunit of an alpha2/beta2 heterotetrameric methanol dehydrogenase in Methylobacterium extorquens.


Pssm-ID: 274419 [Multi-domain]  Cd Length: 527  Bit Score: 860.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  32 DQLMNDAATTGDVLTYGIGPQQQRFSPLAAINTENVARMVPAFAASLGgeKQRGQESQPIVYDGVIYVTGSYSRLFAFDA 111
Cdd:TIGR03075   9 EDLLNDAKDPSDWLTYGGGYAGQRYSPLDQINTDNVKKLQPAWTFSLG--KQRGQESQPLVVDGVMYVTTSYSRVYALDA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 112 RNGEKLWEYNHRLPDGIMP--CCDVVNRGAAIHGDKVIFATLDARLVALNRKTGKVIWNKMTADYKAGYSATAAPIIVKN 189
Cdd:TIGR03075  87 KTGKILWKYDPKLPDDIIPvmCCDVVNRGAALYDGKVFFGTLDARLVALDAKTGKVVWSKKNGDYKKGYTITAAPLVVKG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 190 LVITGNSGGEFGAVGEVQARNVDTGELVWTRPVIEGHMGTLNGKDNGLTGKINA-TWQGDMWKTGGGATWLGGTYDPDTN 268
Cdd:TIGR03075 167 KVITGISGGEFGVRGYVTAYDAKTGKLVWRRYTVPGDMGYLKKTGKPVGGDPGAkTWPGDAWKTGGGATWGTGSYDPETN 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 269 LVFFGTGNPAPWNSHLRPGDNLYTASTVAIDPDTGVIKWHYQTTPNDGWDFDGVNEFIPFDGTFGGKKMKLGAKADRNGY 348
Cdd:TIGR03075 247 LIYFGTGNPAPWNSHLRPGDNLYTSSIVARDPDTGKIKWHYQTTPHDEWDYDGVNEMILFDLKKDGKPRKLLAHADRNGF 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 349 FYVLDRTNGRLLNATPFVMQPNWASKIDLKTGRPVYNAENRPGAPgtaEKGKPVFATPSFLGGKNWMPMAYSPDTEMFYV 428
Cdd:TIGR03075 327 FYVLDRTNGKLLSAEPFVDKVNWATGVDLKTGRPIEVPEARSTDG---KKGKPVEVCPGFLGGKNWQPMAYSPKTGLFYV 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 429 PSNDWGMDIWNEPIAYKKGAAYLGAGFTIKPIAEDHIGALRAVDPKTGKIMWEYKNKAPLWGGVLTTRGNLVFTGTPEGY 508
Cdd:TIGR03075 404 PANHVCMDYWPEKVSYKKGAAYLGAGFTIKPPPDDHIGSLIAWDPITGKIVWEHKEDFPLWGGVLATAGDLVFTGTLEGY 483

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 1036422517 509 LKAFDAKTGKELWKFQTGSGVVGSPVTWEQDGEQYVAVMSGWGG 552
Cdd:TIGR03075 484 FKAFDAKTGEELWKFKTGSGIVGPPVTYEQDGKQYVAVLSGWGG 527
Gcd COG4993
Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];
40-580 0e+00

Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];


Pssm-ID: 444017 [Multi-domain]  Cd Length: 515  Bit Score: 740.82  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  40 TTGDVLTYGIGPQQQRFSPLAAINTENVARMVPAFAASLGGEKQRGQESQPIVYDGVIYVTGSYSRLFAFDARNGEKLWE 119
Cdd:COG4993     1 DPGDWLAYGGDYAGQRYSPLDQINPDNVKKLKVAWTFSTGDLPERGHEATPLVVDGVLYVCTPHNRVFALDAATGKELWR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 120 YNHRLPDGIMpCCDVVNRGAAIHGDKVIFATLDARLVALNRKTGKVIWNKMTADYKAGYSATAAPIIVKNLVITGNSGGE 199
Cdd:COG4993    81 YDPKLPDDAA-CCDVVNRGVAYYDGRIFLGTLDGRLVALDAKTGKVCWDVKVGDPKKGYTITSAPLVVKDKVIVGGSGGE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 200 FGAVGEVQARNVDTGELVWTRPVIEGHmgtlngkdnglTGKINATWQ-GDMWKTGGGATWLGGTYDPDTNLVFFGTGNPA 278
Cdd:COG4993   160 FGPRGVVRAYDARTGKLVWRFDTIPDP-----------GEPGAETWPpGDTWKRGGGNVWGTMSYDPELGLVYLPTGNPA 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 279 P-WNSHLRPGDNLYTASTVAIDPDTGVIKWHYQTTPNDGWDFDGVNEFIPFDGTFGGKKMKLGAKADRNGYFYVLDRTNG 357
Cdd:COG4993   229 PdWNGGQRPGDNLYSSSIVALDADTGELKWHYQTVPHDLWDYDGPNEPILVDLPVDGKTRKALVQATKNGFIYVLDRETG 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 358 RLLNATPFVMQPNWASKIDLKTGRPVYNAenrpgapgTAEKGKPVFATPSFLGGKNWMPMAYSPDTEMFYVPSNDWGMDI 437
Cdd:COG4993   309 EPLVTQPFVKPPNWATEIDMWGATPIQTP--------PSLDGKTTLICPGALGGKNWGPAAYDPETGLLYVPANELCMDY 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 438 WNEPIAYKKGAAYLGAGFTIKPIAEDHIGALRAVDPKTGKIMWEYKNKAPLWGGVLTTRGNLVFTGTPEGYLKAFDAKTG 517
Cdd:COG4993   381 ELVPREYQAGAPYLGATLTMYPCPAPPWGTLTAIDLNTGKIVWQVPLGFPNWGGPLATAGGLVFIGTLDGYLRAFDAKTG 460

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1036422517 518 KELWKFQTGSGVVGSPVTWEQDGEQYVAVMSGWGGAVPLWGGevaktfkeISQGGSLWVFKLP 580
Cdd:COG4993   461 KELWKFRLPSGGQATPMTYEVDGKQYVAVAAGGGGWLGLGLY--------TPQGDYLIAFALP 515
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 90-228 1.93e-16

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 78.98  E-value: 1.93e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  90 PIVYDGVIYVTGSYSRLFAFDARNGEKLWEYNHRLPDGIMpccdVVNRGAAIHGDKVIFATLDARLVALNRKTGKVIWN- 168
Cdd:pfam13360  69 PLVAGGRVFVVAGDGSLIALDAADGRRLWSYQRSGEPLAL----RSSGSPAVVGDTVVAGFSSGKLVALDPATGKVRWEa 144

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1036422517 169 -----KMTADYKAGYSATAAPIIVKNLVITGNSGGEFGAVgevqarNVDTGELVWTRPvIEGHMG 228
Cdd:pfam13360 145 plaapRGTNELERLVDITGTPVVAGGRVFASAYQGRLVAF------DAATGRRLWTRE-ISGPNG 202
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 90-307 2.39e-12

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 68.80  E-value: 2.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  90 PIVYDGVIYVTGSYSRLFAFDARNGEKLWEYNHRLPDGIMPccdvVNRGAAIHG------DKVIFATLDARLVALNRKTG 163
Cdd:PRK11138   65 PAVAYNKVYAADRAGLVKALDADTGKEIWSVDLSEKDGWFS----KNKSALLSGgvtvagGKVYIGSEKGQVYALNAEDG 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 164 KVIWNKmtadyKAGYSATAAPIIVKNLVI--TGNsggefgavGEVQARNVDTGELVWT--------------RPVIEGHm 227
Cdd:PRK11138  141 EVAWQT-----KVAGEALSRPVVSDGLVLvhTSN--------GMLQALNESDGAVKWTvnldvpsltlrgesAPATAFG- 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 228 GTLNGKDNgltGKINATW--QGDM-WK----TGGGATWLGGTYDPDTNLVFFgtgnpapwnshlrpGDNLYTAS----TV 296
Cdd:PRK11138  207 GAIVGGDN---GRVSAVLmeQGQLiWQqrisQPTGATEIDRLVDVDTTPVVV--------------GGVVYALAyngnLV 269

                         250
                  ....*....|.
gi 1036422517 297 AIDPDTGVIKW 307
Cdd:PRK11138  270 ALDLRSGQIVW 280
PQQ smart00564
beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline ...
 90-121 4.33e-04

beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline quinone (PQQ) as cofactor, in Ire1p-like Ser/Thr kinases, and in prokaryotic dehydrogenases.


Pssm-ID: 128836 [Multi-domain]  Cd Length: 33  Bit Score: 37.90  E-value: 4.33e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1036422517   90 PIVYDGVIYVTGSYSRLFAFDARNGEKLWEYN 121
Cdd:smart00564   2 VVLSDGTVYVGSTDGTLYALDAKTGEILWTYK 33
 
Name Accession Description Interval E-value
PQQ_ADH_I cd10277
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); ...
 34-579 0e+00

Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); This bacterial family of homodimeric ethanol dehydrogenases utilize pyrroloquinoline quinone (PQQ) as a cofactor. It represents proteins whose expression may be induced by ethanol, and which are similar to quinoprotein methanol dehydrogenases, but have higher specificities for ethanol and other primary and secondary alcohols. Dehydrogenases with PQQ cofactors, such as ethanol, methanol, and membrane-bound glucose dehydrogenases, form an 8-bladed beta-propeller.


Pssm-ID: 199835 [Multi-domain]  Cd Length: 529  Bit Score: 885.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  34 LMNDAATTGDVLTYGIGPQQQRFSPLAAINTENVARMVPAFAASLGGeKQRGQESQPIVYDGVIYVTGSYSRLFAFDARN 113
Cdd:cd10277     1 LLNDAKETGNWLTYGRGYNGQRYSPLKQINTDNVKNLVPAWSFSFGG-KQRGQESQPIVNDGVMYVTTSYNRVFAIDAKT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 114 GEKLWEYNHRLPDGIMPCCDVVNRGAAIHGDKVIFATLDARLVALNRKTGKVIWNKMTADYKAGYSATAAPIIVKNLVIT 193
Cdd:cd10277    80 GKELWKYKHRLPEDIRPCCDVVNRGVALYGDKVYFGTLDAHLVALDAKTGKVVWKKKVADYKAGYSMTLAPLVVKGKVIV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 194 GNSGGEFGAVGEVQARNVDTGELVWTRPVIEGHMGTLNGKdngltgkinaTWQGDMWKTGGGATWLGGTYDPDTNLVFFG 273
Cdd:cd10277   160 GVSGGEFGVRGFIAALDAETGKEVWRTYTVPGPGEPGSTD----------TWPGDAWKTGGGATWLTGTYDPETNLLYWG 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 274 TGNPAPWNSHLRPGDNLYTASTVAIDPDTGVIKWHYQTTPNDGWDFDGVNEFIPFDGTFGGKKMKLGAKADRNGYFYVLD 353
Cdd:cd10277   230 VGNPAPWNGDLRPGDNLYTSSVLALDPDTGKIKWHYQYTPNDTWDYDGVNEPVLFDYTKNGKPVKALVHADRNGFFYVLD 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 354 RTNGRLLNATPFVMQPNWASkIDLKTGRPVYNAENRPGapgtaEKGKPVFATPSFLGGKNWMPMAYSPDTEMFYVPSNDW 433
Cdd:cd10277   310 RTNGKLIWATPFVKKITWAS-IDLKTGRPIYDEDKVPP-----KKGKTVDFCPSFLGGKNWPPMAYSPDTGLFYVPANHW 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 434 GMDIWNEPIAYKKGAAYLGAGFTIKPIAEDHIGALRAVDPKTGKIMWEYKNKAPLWGGVLTTRGNLVFTGTPEGYLKAFD 513
Cdd:cd10277   384 CMDLTGEPVSYKKGAAYLGAGFTIKPPFEDHIGELQAIDPTTGKKVWEHKTPLPLWGGVLTTAGGLVFTGTPDGYFRAFD 463

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1036422517 514 AKTGKELWKFQTGSGVVGSPVTWEQDGEQYVAVMSGWGGAVPLWGGEVAKTFKEISQGGSLWVFKL 579
Cdd:cd10277   464 AKTGKELWEFQTGSGIIGPPVTWEVDGKQYVAVLSGWGGAAPLWGGDMAKLLKNVPQGGSLWVFAL 529
PQQ_enz_alc_DH TIGR03075
PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic ...
 32-552 0e+00

PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Genes in this family often are found adjacent to the PQQ biosynthesis genes themselves. An unusual, strained disulfide bond between adjacent Cys residues contributes to PQQ-binding, as does a Trp residue that is part of a PQQ enzyme repeat (see pfam01011). Characterized members include the dehydrogenase subunit of a membrane-anchored, three subunit alcohol (ethanol) dehydrogenase of Gluconobacter suboxydans, a homodimeric ethanol dehydrogenase in Pseudomonas aeruginosa, and the large subunit of an alpha2/beta2 heterotetrameric methanol dehydrogenase in Methylobacterium extorquens.


Pssm-ID: 274419 [Multi-domain]  Cd Length: 527  Bit Score: 860.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  32 DQLMNDAATTGDVLTYGIGPQQQRFSPLAAINTENVARMVPAFAASLGgeKQRGQESQPIVYDGVIYVTGSYSRLFAFDA 111
Cdd:TIGR03075   9 EDLLNDAKDPSDWLTYGGGYAGQRYSPLDQINTDNVKKLQPAWTFSLG--KQRGQESQPLVVDGVMYVTTSYSRVYALDA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 112 RNGEKLWEYNHRLPDGIMP--CCDVVNRGAAIHGDKVIFATLDARLVALNRKTGKVIWNKMTADYKAGYSATAAPIIVKN 189
Cdd:TIGR03075  87 KTGKILWKYDPKLPDDIIPvmCCDVVNRGAALYDGKVFFGTLDARLVALDAKTGKVVWSKKNGDYKKGYTITAAPLVVKG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 190 LVITGNSGGEFGAVGEVQARNVDTGELVWTRPVIEGHMGTLNGKDNGLTGKINA-TWQGDMWKTGGGATWLGGTYDPDTN 268
Cdd:TIGR03075 167 KVITGISGGEFGVRGYVTAYDAKTGKLVWRRYTVPGDMGYLKKTGKPVGGDPGAkTWPGDAWKTGGGATWGTGSYDPETN 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 269 LVFFGTGNPAPWNSHLRPGDNLYTASTVAIDPDTGVIKWHYQTTPNDGWDFDGVNEFIPFDGTFGGKKMKLGAKADRNGY 348
Cdd:TIGR03075 247 LIYFGTGNPAPWNSHLRPGDNLYTSSIVARDPDTGKIKWHYQTTPHDEWDYDGVNEMILFDLKKDGKPRKLLAHADRNGF 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 349 FYVLDRTNGRLLNATPFVMQPNWASKIDLKTGRPVYNAENRPGAPgtaEKGKPVFATPSFLGGKNWMPMAYSPDTEMFYV 428
Cdd:TIGR03075 327 FYVLDRTNGKLLSAEPFVDKVNWATGVDLKTGRPIEVPEARSTDG---KKGKPVEVCPGFLGGKNWQPMAYSPKTGLFYV 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 429 PSNDWGMDIWNEPIAYKKGAAYLGAGFTIKPIAEDHIGALRAVDPKTGKIMWEYKNKAPLWGGVLTTRGNLVFTGTPEGY 508
Cdd:TIGR03075 404 PANHVCMDYWPEKVSYKKGAAYLGAGFTIKPPPDDHIGSLIAWDPITGKIVWEHKEDFPLWGGVLATAGDLVFTGTLEGY 483

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 1036422517 509 LKAFDAKTGKELWKFQTGSGVVGSPVTWEQDGEQYVAVMSGWGG 552
Cdd:TIGR03075 484 FKAFDAKTGEELWKFKTGSGIVGPPVTYEQDGKQYVAVLSGWGG 527
Gcd COG4993
Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];
40-580 0e+00

Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];


Pssm-ID: 444017 [Multi-domain]  Cd Length: 515  Bit Score: 740.82  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  40 TTGDVLTYGIGPQQQRFSPLAAINTENVARMVPAFAASLGGEKQRGQESQPIVYDGVIYVTGSYSRLFAFDARNGEKLWE 119
Cdd:COG4993     1 DPGDWLAYGGDYAGQRYSPLDQINPDNVKKLKVAWTFSTGDLPERGHEATPLVVDGVLYVCTPHNRVFALDAATGKELWR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 120 YNHRLPDGIMpCCDVVNRGAAIHGDKVIFATLDARLVALNRKTGKVIWNKMTADYKAGYSATAAPIIVKNLVITGNSGGE 199
Cdd:COG4993    81 YDPKLPDDAA-CCDVVNRGVAYYDGRIFLGTLDGRLVALDAKTGKVCWDVKVGDPKKGYTITSAPLVVKDKVIVGGSGGE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 200 FGAVGEVQARNVDTGELVWTRPVIEGHmgtlngkdnglTGKINATWQ-GDMWKTGGGATWLGGTYDPDTNLVFFGTGNPA 278
Cdd:COG4993   160 FGPRGVVRAYDARTGKLVWRFDTIPDP-----------GEPGAETWPpGDTWKRGGGNVWGTMSYDPELGLVYLPTGNPA 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 279 P-WNSHLRPGDNLYTASTVAIDPDTGVIKWHYQTTPNDGWDFDGVNEFIPFDGTFGGKKMKLGAKADRNGYFYVLDRTNG 357
Cdd:COG4993   229 PdWNGGQRPGDNLYSSSIVALDADTGELKWHYQTVPHDLWDYDGPNEPILVDLPVDGKTRKALVQATKNGFIYVLDRETG 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 358 RLLNATPFVMQPNWASKIDLKTGRPVYNAenrpgapgTAEKGKPVFATPSFLGGKNWMPMAYSPDTEMFYVPSNDWGMDI 437
Cdd:COG4993   309 EPLVTQPFVKPPNWATEIDMWGATPIQTP--------PSLDGKTTLICPGALGGKNWGPAAYDPETGLLYVPANELCMDY 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 438 WNEPIAYKKGAAYLGAGFTIKPIAEDHIGALRAVDPKTGKIMWEYKNKAPLWGGVLTTRGNLVFTGTPEGYLKAFDAKTG 517
Cdd:COG4993   381 ELVPREYQAGAPYLGATLTMYPCPAPPWGTLTAIDLNTGKIVWQVPLGFPNWGGPLATAGGLVFIGTLDGYLRAFDAKTG 460

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1036422517 518 KELWKFQTGSGVVGSPVTWEQDGEQYVAVMSGWGGAVPLWGGevaktfkeISQGGSLWVFKLP 580
Cdd:COG4993   461 KELWKFRLPSGGQATPMTYEVDGKQYVAVAAGGGGWLGLGLY--------TPQGDYLIAFALP 515
PQQ_ADH_II cd10279
PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); This family of ...
 42-579 0e+00

PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); This family of monomeric and soluble type II alcohol dehydrogenases utilizes pyrroloquinoline quinone (PQQ) as a cofactor and is related to ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller.


Pssm-ID: 199837 [Multi-domain]  Cd Length: 549  Bit Score: 534.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  42 GDVLTYGIGPQQQRFSPLAAINTENVARMVPAFAASLGGEkqRGQESQPIVYDGVIYVTGSYSRLFAFDARNGEKLWEYN 121
Cdd:cd10279     1 GNWLSYGRDYDEQRFSPLTQINRSNVGQLGLAWYFDLDTN--RGQEATPLVVDGVMYVSGPWSVVYALDARTGKLLWQYD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 122 HRLPDGIM--PCCDVVNRGAAIHGDKVIFATLDARLVALNRKTGKVIWNKMTADYKAGYSATAAPIIVKNLVITGNSGGE 199
Cdd:cd10279    79 PEVDRESGrkACCDVVNRGVAVWDGKVFVGTLDGRLIALDAKTGKEVWSVDTIDPRKPYTITGAPRVAKGKVVIGNGGAE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 200 FGAVGEVQARNVDTGELVW---TRPvieghmGTLNGKDNGLTGKINA--TWQGDMWKTGGGAT-WLGGTYDPDTNLVFFG 273
Cdd:cd10279   159 FGVRGYVSAYDAETGKLVWrfyTVP------GNPAKPFEHASLEAAAatWWTGEWWRTGGGGTvWDSITYDPELDLLYIG 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 274 TGNPAPWNSHLRP---GDNLYTASTVAIDPDTGVIKWHYQTTPNDGWDFDGVNEFIPFDGTFGGKKMKLGAKADRNGYFY 350
Cdd:cd10279   233 TGNGSPWNRKVRSpggGDNLFLSSIVALDADTGRYKWHYQTTPGDTWDYTATQPIILADLEIDGKPRKVLMHAPKNGFFY 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 351 VLDRTNGRLLNATPFVMQpNWASKIDLKTGRPVYNAENRPGApgtaekgKPVFATPSFLGGKNWMPMAYSPDTEMFYVPS 430
Cdd:cd10279   313 VLDRATGKLLSAEPFVPV-NWATGIDLKTGRPIENPEARYTK-------GPKLVFPGPLGAHNWHPMSYNPDTGLVYIPA 384

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 431 NDWGMDIWNEPIAYKKGAAYLGAGFT----------IKPIAEDHIGALRAVDPKTGKIMWEYKNKAPLWGGVLTTRGNLV 500
Cdd:cd10279   385 QEIPAVYEDDPGDFGYNPLGWNTGITpdatpppaaaKRALRKATRGRLVAWDPVTQKAAWRVEHPGPWNGGVLATAGNLV 464

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1036422517 501 FTGTPEGYLKAFDAKTGKELWKFQTGSGVVGSPVTWEQDGEQYVAVMSGWGGAVPLWGGeVAKTFKEISQGGSLWVFKL 579
Cdd:cd10279   465 FQGTADGELAAYDARTGEKLWSFDTGSGIVAAPMTYSVDGEQYVAVLAGWGGAGALSGG-PPGAAGKVQNPGRLLVFKL 542
PQQ_MDH cd10278
Large subunit of methanol dehydrogenase (moxF); Methanol dehydrogenase is a key enzyme in the ...
 54-579 0e+00

Large subunit of methanol dehydrogenase (moxF); Methanol dehydrogenase is a key enzyme in the utilization of C1 compounds as a source of energy and carbon by bacteria. It catalyzes the oxidation of methanol to formaldehyde, transfering two electrons per methanol to cytochrome c(L) as the acceptor. Methanol dehydrogenase belongs to a family of dehydrogenases with pyrroloquinoline quinone (PQQ) as cofactor, which also includes dehydrogenases specific to other alcohols and membrane-bound glucose dehydrogenases. This alignment model for the large subunit contains an 8-bladed beta-propeller; the functional enzyme forms a heterotetramer composed of two large and two small subunits.


Pssm-ID: 199836 [Multi-domain]  Cd Length: 553  Bit Score: 522.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  54 QRFSPLAAINTENVARMVPAFAASLGgeKQRGQESQPIVYDGVIYVTGSY-SRLFAFD-ARNGEKLWEYNHRLPDGIMP- 130
Cdd:cd10278    11 TRYSPLAQINKDNVKNLKVAWTFSTG--VLRGHEGAPLVVGDTMYVVTPFpNNVYALDlNDPGKILWKYKPKQDPSAVAv 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 131 -CCDVVNRGAAIHGDKVIFATLDARLVALNRKTGKVIWNKMTADYKAGYSATAAPIIVKNLVITGNSGGEFGAVGEVQAR 209
Cdd:cd10278    89 aCCDVVNRGLAYADGKIFFNQLDGHLVALDAKTGKEVWKVKNGDPKVGETLTMAPLVVKDKVIVGISGGEFGVRGYVTAY 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 210 NVDTGELVWTR------------PVIEGHMGTLNGKDNGLTgkinaTWQGDMWKTGGGATWLGGTYDPDTNLVFFGTGNP 277
Cdd:cd10278   169 DLKTGKLVWRAystgpdkdvligPDFNPFNPHDGGKDLGLS-----TWPGDAWKIGGGTNWGWYSYDPKLNLVYYGTGNP 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 278 APWNSHLRPGDNLYTASTVAIDPDTGVIKWHYQTTPNDGWDFDGVNEFIPFDGTFGGKKMKLGAKADRNGYFYVLDRTNG 357
Cdd:cd10278   244 GPWNPTQRPGDNKWSMTIFARDPDTGEAKWAYQMTPHDEWDYDGVNEMILVDQTVDGKKRKLLVHFDRNGFVYTLDRTTG 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 358 RLLNATPFVMQpNWASKIDLKTGRPVYNAENRPGAPGTAEKgkpvfATPSFLGGKNWMPMAYSPDTEMFYVPSNDWGMDI 437
Cdd:cd10278   324 ELLSAEKFDPV-NNWKGVDLKTGRPVKDPEKSTHMDHNVTD-----ICPSAMGGKDQQPSSYSPKTGLFYVPTNHLCMDY 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 438 WNEPIAYKKGAAYLGAGFTIKPIAEDHIGALRAVDPKTGKIMWEYKNKAPLWGGVLTTRGNLVFTGTPEGYLKAFDAKTG 517
Cdd:cd10278   398 EPFEVNYTAGQPYVGATLAMYPGPGGHMGQFKAWDPVTGKTKWEIKERFPVWSGTLATAGGLVFYGTLDGWFKAVDAKTG 477

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1036422517 518 KELWKFQTGSGVVGSPVTWEQDGEQYVAVMSGWGG--AVPLWGGEVAKT--------FKEISQ----GGSLWVFKL 579
Cdd:cd10278   478 KLLWKFKLPSGIIGNPITYKHDGKQYVAVLSGVGGwaGVGVAAGLRDPTaglgavgaFKDLPNytqmGGTLYVFSL 553
PQQ_DH_like cd00216
PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases ...
 65-578 7.73e-160

PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases with pyrroloquinoline quinone (PQQ) as a cofactor, such as ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller, and the family also includes distantly related proteins which are not enzymatically active and do not bind PQQ.


Pssm-ID: 199833 [Multi-domain]  Cd Length: 434  Bit Score: 463.62  E-value: 7.73e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  65 ENVARMVPAFAASLGGEKQRGQESQPIVYDGVIYVTGSYSRLFAFDARNGEKLWEYNHRLPDG-IMPCCDVVNRGAAIHG 143
Cdd:cd00216     2 DNVFQLTPAWSFSTGDGGNRGSELTPIVVDGVMYATTSFSRVFALDADDGKEIWSYDPALKDGwFEACCDLVNRGVAVWG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 144 DKVIFATLDARLVALNRKTGKVIWNKMTADYKAGYSATAAPIIVKNLVITGNSGGEFGAVGEVQARNVDTGELVWTRPVI 223
Cdd:cd00216    82 GKVYIGVLDGRVYALNAETGKVAWKVKNADVLGGYTATSAPVVVDGLVIIGSSGDEFGVRGYLTAYDVATGEEKWRFYLV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 224 EGHMGTLNGKDNGLTGKINATWQGDMWKTGGGATWLGGTYDPDTNLVFFGTGNPAPWN--SHLRPGDNLYTASTVAIDPD 301
Cdd:cd00216   162 MPDPNLLPGKDSTVTDRNTPTGDEHTWTSGGGTGWSSAAYDAELNLIYVGGGNPTPWNwgGNRTPGDNLYTSSIVAVNAD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 302 TGVIKWHYQTTPNDGWDFDGVNEFIPFDGTFGGKKMKLGAKADRNGYFYVLDRTNGRLLNATPFVmqpnwaskidlktgr 381
Cdd:cd00216   242 TGEMKWQYQTTPHDAWDYDGDNTPVLADIKVKGKKVKVLFAPAKNGNFYVLDRRNGELVSARPLV--------------- 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 382 pvynaenrpgapgtaekgkpvfatpsflggknwmPMAYSPDTEMFYVPSNdwgmdiwnepiaykkgaaylgagftikpia 461
Cdd:cd00216   307 ----------------------------------PDSYDPDRELFYVPAN------------------------------ 322

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 462 edhiGALRAVDPKTGKIMWEYKNKAPLWGGVLTTRGNLVFTGTPEGYLKAFDAKTGKELWKFQTGSGVVGSPVTWEQDGE 541
Cdd:cd00216   323 ----GRIMALDPVTGVVVWEKSELHPLLGGPLSTAGNLVFVGTSDGYLKAYNADTGEKLWQQKVPSGFQAEPVTYEVDGE 398

                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 1036422517 542 QYVAVMSGWGGAVPLWGGeVAKTFKEISQGGSLWVFK 578
Cdd:cd00216   399 QYVLIQAGGGGAFPLWGG-MADLTRGTQMGGTVVVYK 434
PQQ_mGDH cd10280
Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes ...
 46-552 1.08e-80

Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes belongs to the dehydrogenase family with pyrroloquinoline quinone (PQQ) as cofactor, and is the only subfamily that is bound to the membrane. Glucose dehydrogenase converts D-glucose to D-glucono-1,5-lactone in a reaction that is coupled with the respiratory chain in the periplasmic oxidation of sugars and alcohols in gram-negative bacteria. Ubiquinone functions as the electron acceptor. The alignment model contains an 8-bladed beta-propeller.


Pssm-ID: 199838 [Multi-domain]  Cd Length: 616  Bit Score: 265.21  E-value: 1.08e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  46 TYGIGPQQQRFSPLAAINTENVARMVPAFAASLGGEKQRGQ-----ESQPIVYDGVIYVTGSYSRLFAFDARNGEKLWEY 120
Cdd:cd10280     3 AYGGDPGGTRYSPLDQITPDNVGKLKVAWTYHTGDLPGPDGnegtfEATPLKVGGTLYLCTPHNRVIALDAATGKELWRF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 121 N----HRLPDGIMPCcdvvnRGAAIHGDK---------VIFATLDARLVALNRKTGKVIW---NKMTADYKAG------- 177
Cdd:cd10280    83 DpkagADAAPGHQTC-----RGVSYWEDGaaaaacarrIFFGTGDARLIALDARTGKPCPdfgDNGVVDLREGlgrvkpg 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 178 -YSATAAPIIVKNLVITGNSGGEFGAVGE----VQARNVDTGELVWTRpviegHMGTLNGKDNGLTGkinatwqgDMWKT 252
Cdd:cd10280   158 fYSSTSPPTVYGDLVIVGSAVADNQAVDApsgvIRAFDVRTGKLVWAF-----DTIPPPGEAGPDTA--------GAWYT 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 253 GGGA-TWLGGTYDPDTNLVFFGTGNPAP--WNSHlRPGDNLYTASTVAIDPDTGVIKWHYQTTPNDGWDFDgvnefIP-- 327
Cdd:cd10280   225 RGGPnVWAGMSADEKLGLVYLPTGSATPdfYGGD-RPGDNLFANSLVALDAATGKRRWHFQTVHHDLWDYD-----LPaq 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 328 ---FDGTFGGKKMKLGAKADRNGYFYVLDRTNGRLL------------------NAT------PFVMQPNWASKIDLKTG 380
Cdd:cd10280   299 ptlVDVPRDGKTVPAVAQPTKQGFVFVLDRRTGKPLwpveerpvpqgdvpgertSPTqpfptlPPPFARQGLTEDDMWGA 378

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 381 RPV-----------YNAENR---PGAPGTaekgkpvFATPSFLGGKNWMPMAYSPDTEMFYVPSNDWGMDIW---NEPIA 443
Cdd:cd10280   379 TPFdqlacriqfrsLRYEGLftpPSLDGT-------LIFPGNDGGANWGGAAVDPERGILYVNSNRLPFVIQlvpRAPGD 451

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 444 YKKGAAYLGAGFTIKPIAEDHI-----------------------GALRAVDPKTGKIMW-----EYKNKAPL------- 488
Cdd:cd10280   452 PAGVAGGGEGGGGGGGPSPQAGtpygvgrgrflsplglpcqappwGTLTAIDLNTGKILWqvplgTVPDLGPKgiplpip 531

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 489 -----WGGVLTTRGNLVFTG-TPEGYLKAFDAKTGKELWKFQTGSGVVGSPVTWEQDGEQYVAVMSGWGG 552
Cdd:cd10280   532 tgtpnLGGPVVTAGGLVFIAaTQDNYLRAFDKATGKELWEARLPAGGQATPMTYEVDGKQYVVIAAGGHG 601
PQQ_membr_DH TIGR03074
membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; This protein ...
 47-549 5.16e-47

membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Members of this family have several predicted transmembrane helices in the N-terminal region, and include the quinoprotein glucose dehydrogenase (EC 1.1.5.2) of Escherichia coli and the quinate/shikimate dehydrogenase of Acinetobacter sp. ADP1 (EC 1.1.99.25). Sequences closely related except for the absense of the N-terminal hydrophobic region, scoring in the gray zone between the trusted and noise cutoffs, include PQQ-dependent glycerol (EC 1.1.99.22) and and other polyol (sugar alcohol) dehydrogenases.


Pssm-ID: 274418 [Multi-domain]  Cd Length: 764  Bit Score: 175.96  E-value: 5.16e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  47 YGIGPQQQRFSPLAAINTENVARMVPAFAASLGGEKQRGQ------ESQPIVYDGVIYVTGSYSRLFAFDARNGEKLWEY 120
Cdd:TIGR03074 141 YGRTQAGQRYSPLDQINPDNVGNLKVAWTYHTGDLKTPDDpgeatfQATPLKVGDTLYLCTPHNKVIALDAATGKEKWKF 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 121 NHRLPDGIMP----CcdvvnRGAAIHGD------------------KVIFATLDARLVALNRKTGKV---IWNKMTADYK 175
Cdd:TIGR03074 221 DPKLKTEADRqhqtC-----RGVSYYDApaaaagpagpaapadcarRIILPTSDARLIALDADTGKLcedFGNNGTVDLT 295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 176 AG--------YSATAAPIIVKNLVITGNSGGEFGAVGE----VQARNVDTGELVW---------TRPVIEGHMGTLNGKD 234
Cdd:TIGR03074 296 AGmgptppgyYYPTSPPLVAGTTVVIGGRVADNYSTDEpsgvIRAFDVNTGALVWawdpgnpdpTAPPAPGETYTRNSPN 375

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 235 ngltgkinatwqgdMWKTGggatwlggTYDPDTNLVFFGTGNPAP--WNSHLRPGDNLYTASTVAIDPDTGVIKWHYQTT 312
Cdd:TIGR03074 376 --------------SWSVA--------SYDEKLGLVYLPMGNQTPdqWGGDRTPADEKYSSSLVALDATTGKERWVFQTV 433

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 313 PNDGWDFD--GVNEFIPFDGTFGGKKMKL--GAKAdrnGYFYVLDRTNGRLLnaTPFVMQP--------NWASKI----D 376
Cdd:TIGR03074 434 HHDLWDMDvpAQPSLVDLPKADGTTVPALvaPTKQ---GQIYVLDRRTGEPI--VPVEEVPvpqgavpgERYSPTqpfsV 508

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 377 LKTGRPV-----------------------YNAENRPGAPGtaEKGKPVFatPSFLGGKNWMPMAYSPDTEMFYVPSNDW 433
Cdd:TIGR03074 509 LTFGPPTltesdmwgatpfdqlacriqfksLRYEGLYTPPS--EQGSLVF--PGNLGGFNWGGVAVDPTRQVMFVNPMRL 584

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 434 G-------MDIWNEP------------IAYKKGAAY-------LGAgFTIkPIAEDHIGALRAVDPKTGKIMWEYKN--- 484
Cdd:TIGR03074 585 PfvsqlvpRAPGDEApsgakgkgtemgLNPNKGTPYavnmnpfLSP-LGI-PCQAPPWGYMAAIDLKTGKVVWQHPNgtv 662

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 485 --------KAPL--------WGGVLTTRGNLVF-TGTPEGYLKAFDAKTGKELWKFQTGSGVVGSPVTW-EQDGEQYVAV 546
Cdd:TIGR03074 663 rdtgpmgiPMPLpipigvptLGGPLATAGGLVFiGATQDNYLRAYDLSTGKELWEARLPAGGQATPMTYmGKDGKQYVVI 742


                  ...
gi 1036422517 547 MSG 549
Cdd:TIGR03074 743 VAG 745
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 90-228 1.93e-16

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 78.98  E-value: 1.93e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  90 PIVYDGVIYVTGSYSRLFAFDARNGEKLWEYNHRLPDGIMpccdVVNRGAAIHGDKVIFATLDARLVALNRKTGKVIWN- 168
Cdd:pfam13360  69 PLVAGGRVFVVAGDGSLIALDAADGRRLWSYQRSGEPLAL----RSSGSPAVVGDTVVAGFSSGKLVALDPATGKVRWEa 144

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1036422517 169 -----KMTADYKAGYSATAAPIIVKNLVITGNSGGEFGAVgevqarNVDTGELVWTRPvIEGHMG 228
Cdd:pfam13360 145 plaapRGTNELERLVDITGTPVVAGGRVFASAYQGRLVAF------DAATGRRLWTRE-ISGPNG 202
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 57-222 1.82e-15

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 78.32  E-value: 1.82e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  57 SPLAAIntENVARMVPAFAASLGGEKQRGQES-QPIVYDGVIYVTGSYSRLFAFDARNGEKLWEYNHRLPdgimpccdvV 135
Cdd:COG1520    21 APLPEF--EPSVKVKQLWSASVGDGVGKGYSRlAPAVAGDRVYAADADGRVAALDAATGKELWRVDLGEP---------L 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 136 NRGAAIHGDKVIFATLDARLVALNRKTGKVIWNK-------------------MTADYK-AGYSA--------------- 180
Cdd:COG1520    90 SGGVGADGGLVVVGTEDGEVIALDADDGEELWRArlssevlaapavaggrvvvRTGDGRvYALDAatgerlwsyqrpvpa 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1036422517 181 -----TAAPIIVKNLVITGNSGGEFGAVgevqarNVDTGELVWTRPV 222
Cdd:COG1520   170 ltlrgTSSPVIVGGAVLVGFANGKLVAL------DLANGQPLWEQRV 210
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 88-222 3.13e-13

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 71.38  E-value: 3.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  88 SQPIVYDGVIYVTGSYSRLFAFDARNGEKLWEYNHRLPDGIMpccdvvnRGAA---IHGDKVIFATLDARLVALNRKTGK 164
Cdd:COG1520   131 AAPAVAGGRVVVRTGDGRVYALDAATGERLWSYQRPVPALTL-------RGTSspvIVGGAVLVGFANGKLVALDLANGQ 203

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 165 VIWNKMTA------------DykagysATAAPIIVKNLVITGNSGGEFGAVgevqarNVDTGELVWTRPV 222
Cdd:COG1520   204 PLWEQRVAqprgrtelerlvD------VDGTPVVDGGVVYAVAYQGRLAAL------DLRSGRVLWSRDL 261
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 76-307 6.19e-13

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 70.44  E-value: 6.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  76 ASLGGEKQRGQESQPIVYDGVIYVTGSYSRLFAFDARNGEKLWEYNhrLPDGIMpccdvVNRGAAIHGDKVIFATLDARL 155
Cdd:cd10276    20 KSVGNGGMAGIDLTPVVAGDMVYAADANGQVSAFNATTGKIIWETS--LSGKGF-----LGGTPAVGNGKIFVGTESGYL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 156 VALNRKTGKVIWNKMTADykagYSATAAPIIVKNLVITGNSGgefgavGEVQARNVDTGELVWTRPvieghmgtlngkdn 235
Cdd:cd10276    93 YALDAKDGSELWRTEVSD----SQLLSPPTYADGKIYVGTGD------GRLYYCNAETGKVVWNRT-------------- 148

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1036422517 236 gltgkiNATWQGDMWktgGGATWLGgtydpdTNLVFFGTGNpapwNSHLrpgdnlytastVAIDPDTGVIKW 307
Cdd:cd10276   149 ------STAPELSLR---GGAAPVG------AYDVVFVGDG----NGTV-----------VALNTGTGVDIW 190
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 92-307 6.58e-13

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 68.58  E-value: 6.58e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  92 VYDGVIYVTGSYSRLFAFDARNGEKLWEYNhrlpdgimpcCDVVNRGAAIHGDKVIFA-TLDARLVALNRKTGKVIWNKM 170
Cdd:pfam13360  31 VDGGRLFVATGGGQLVALDAATGKLLWRQT----------LSGEVLGAPLVAGGRVFVvAGDGSLIALDAADGRRLWSYQ 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 171 TADYKAGYSATAAPIIVKNLVITGNSGgefgavGEVQARNVDTGELVWTRPVIEGHMGTlngkDNGLTGKINAT---WQG 247
Cdd:pfam13360 101 RSGEPLALRSSGSPAVVGDTVVAGFSS------GKLVALDPATGKVRWEAPLAAPRGTN----ELERLVDITGTpvvAGG 170

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1036422517 248 DMWKTGGGATWlgGTYDPDTNLVFFgTGNPAPWNSHLRPGDNLYTAST----VAIDPDTGVIKW 307
Cdd:pfam13360 171 RVFASAYQGRL--VAFDAATGRRLW-TREISGPNGPILDGDLLYVVSDdgelYALDRATGAVVW 231
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 90-309 9.38e-13

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 69.67  E-value: 9.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  90 PIVYDGVIYVTGSYSRLFAFDARNGEKLWeyNHRLPDGImpccdvVNRGAAIHGDKVIFATLDARLVALNRKTGKVIWNK 169
Cdd:cd10276    76 PAVGNGKIFVGTESGYLYALDAKDGSELW--RTEVSDSQ------LLSPPTYADGKIYVGTGDGRLYYCNAETGKVVWNR 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 170 MTADYKAGYSATAAPIIVKNLVITGNSGgefgavGEVQARNVDTGELVWTRPVIEGH-MGTLNGKDngltgKINATW-QG 247
Cdd:cd10276   148 TSTAPELSLRGGAAPVGAYDVVFVGDGN------GTVVALNTGTGVDIWEFSVSEPRgRTELPRMI-----DSSVTYvVV 216

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1036422517 248 DMW---KTGGGATWlggTYDPDTNLVFF------GTGNPAPWNSHLRPGDNlyTASTVAIDPDTGVIKWHY 309
Cdd:cd10276   217 GGYlysTSYQGYLV---ALDFESGQFLWsrkasgGTSTSTDANGRVYVGDG--EGSLYCLDASTGDELWSQ 282
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 466-535 1.70e-12

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 69.19  E-value: 1.70e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 466 GALRAVDPKTGKIMWEYKNKAPLWGGVlTTRGNLVFTGTPEGYLKAFDAKTGKELWKFQTGSGVVGSPVT 535
Cdd:TIGR03300  75 GTVAALDAETGKRLWRVDLDERLSGGV-GADGGLVFVGTEKGEVIALDAEDGKELWRAKLSSEVLSPPLV 143
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 90-307 2.39e-12

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 68.80  E-value: 2.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  90 PIVYDGVIYVTGSYSRLFAFDARNGEKLWEYNHRLPDGIMPccdvVNRGAAIHG------DKVIFATLDARLVALNRKTG 163
Cdd:PRK11138   65 PAVAYNKVYAADRAGLVKALDADTGKEIWSVDLSEKDGWFS----KNKSALLSGgvtvagGKVYIGSEKGQVYALNAEDG 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 164 KVIWNKmtadyKAGYSATAAPIIVKNLVI--TGNsggefgavGEVQARNVDTGELVWT--------------RPVIEGHm 227
Cdd:PRK11138  141 EVAWQT-----KVAGEALSRPVVSDGLVLvhTSN--------GMLQALNESDGAVKWTvnldvpsltlrgesAPATAFG- 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 228 GTLNGKDNgltGKINATW--QGDM-WK----TGGGATWLGGTYDPDTNLVFFgtgnpapwnshlrpGDNLYTAS----TV 296
Cdd:PRK11138  207 GAIVGGDN---GRVSAVLmeQGQLiWQqrisQPTGATEIDRLVDVDTTPVVV--------------GGVVYALAyngnLV 269

                         250
                  ....*....|.
gi 1036422517 297 AIDPDTGVIKW 307
Cdd:PRK11138  270 ALDLRSGQIVW 280
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 57-229 1.23e-11

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 66.49  E-value: 1.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  57 SPLAAINTENVARMVpaFAASLG-GEKQRGQESQPIVYDGVIYVTGSYSRLFAFDARNGEKLWEYNHRLPdgimpccdvV 135
Cdd:TIGR03300  29 AELPEFQPTVKVDQV--WSASVGdGVGHYYLRLQPAVAGGKVYAADADGTVAALDAETGKRLWRVDLDER---------L 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 136 NRGAAIHGDKVIFATLDARLVALNRKTGKVIWNK-------------------MTADYK-AGYSA--------------- 180
Cdd:TIGR03300  98 SGGVGADGGLVFVGTEKGEVIALDAEDGKELWRAklssevlspplvanglvvvRTNDGRlTALDAatgerlwtysrvtpp 177

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1036422517 181 -----TAAPIIVKNLVITGNSGGEFGAVgevqarNVDTGELVWTRPVIEGHMGT 229
Cdd:TIGR03300 178 ltlrgSASPVIADGGVLVGFAGGKLVAL------DLQTGQPLWEQRVALPKGRT 225
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 437-549 3.03e-11

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 65.22  E-value: 3.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 437 IWNEPIaykkGAAYLGAGFTIKP-IAEDHI------GALRAVDPKTGKIMWEYKNKAPLWGGVlTTRGNLVFTGTPEGYL 509
Cdd:COG1520    35 LWSASV----GDGVGKGYSRLAPaVAGDRVyaadadGRVAALDAATGKELWRVDLGEPLSGGV-GADGGLVVVGTEDGEV 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1036422517 510 KAFDAKTGKELWKFQTGSGVVGSPVTweqdGEQYVAVMSG 549
Cdd:COG1520   110 IALDADDGEELWRARLSSEVLAAPAV----AGGRVVVRTG 145
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 88-222 3.24e-10

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 62.26  E-value: 3.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  88 SQPIVYDGVIYVTGSYSRLFAFDARNGEKLWEYNHRLPDGIMpccdvvnRGAA---IHGDKVIFATLDARLVALNRKTGK 164
Cdd:TIGR03300 139 SPPLVANGLVVVRTNDGRLTALDAATGERLWTYSRVTPPLTL-------RGSAspvIADGGVLVGFAGGKLVALDLQTGQ 211

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1036422517 165 VIWNKMTAdYKAGYSA-------TAAPIIVKNLVITGNSGGEFGAVgevqarNVDTGELVWTRPV 222
Cdd:TIGR03300 212 PLWEQRVA-LPKGRTElerlvdvDGDPVVDGGQVYAVSYQGRVAAL------DLRSGRVLWKRDA 269
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 88-219 1.18e-09

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 58.95  E-value: 1.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  88 SQPIVYDGVIYVTGSYSRLFAFDARNGEKLWEYNHRLPDGIMPCCDVVNRGAA--IHGDKVIFATLDARLVALNRKTGKV 165
Cdd:pfam13360 112 GSPAVVGDTVVAGFSSGKLVALDPATGKVRWEAPLAAPRGTNELERLVDITGTpvVAGGRVFASAYQGRLVAFDAATGRR 191

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1036422517 166 IWNKmtadykaGYSATAAPIIVKNLVITGNSGgefgavGEVQARNVDTGELVWT 219
Cdd:pfam13360 192 LWTR-------EISGPNGPILDGDLLYVVSDD------GELYALDRATGAVVWK 232
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 466-549 7.02e-09

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 56.64  E-value: 7.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 466 GALRAVDPKTGKIMWEYKNKAPLWGGVlTTRGNLVFTGTPEGYLKAFDAKTGKELWKFQTGSGVVGSPvtwEQDGEQYVA 545
Cdd:pfam13360   3 GVVTALDAATGAELWRVDLETGLGGGV-AVDGGRLFVATGGGQLVALDAATGKLLWRQTLSGEVLGAP---LVAGGRVFV 78


                  ....
gi 1036422517 546 VMSG 549
Cdd:pfam13360  79 VAGD 82
PQQ pfam01011
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller ...
 498-533 3.35e-08

PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller has been found in several enzymes which utilize pyrrolo-quinoline quinone as a prosthetic group.


Pssm-ID: 395799 [Multi-domain]  Cd Length: 36  Bit Score: 49.50  E-value: 3.35e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1036422517 498 NLVFTGTPEGYLKAFDAKTGKELWKFQTGSGVVGSP 533
Cdd:pfam01011   1 GTVYLGSDDGYLYALDAETGKVLWSFKTGGAVLSSP 36
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 466-535 1.20e-07

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 53.87  E-value: 1.20e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1036422517 466 GALRAVDPKTGKIMWEYK-NKAPLWGGVLTTRGNLVFTGTPEGYLKAFDAKTGKELWKFQTGSGVVGSPVT 535
Cdd:cd10276    48 GQVSAFNATTGKIIWETSlSGKGFLGGTPAVGNGKIFVGTESGYLYALDAKDGSELWRTEVSDSQLLSPPT 118
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 87-167 3.85e-07

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 51.25  E-value: 3.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  87 ESQPIVYDGVIYVTGSYSRLFAFDARNGEKLWEynhRLPDGIMpccdvvnrGAAIHGDKVIFATLDARLVALNRKTGKVI 166
Cdd:pfam13360 162 TGTPVVAGGRVFASAYQGRLVAFDAATGRRLWT---REISGPN--------GPILDGDLLYVVSDDGELYALDRATGAVV 230


                  .
gi 1036422517 167 W 167
Cdd:pfam13360 231 W 231
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 461-551 1.46e-06

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 50.70  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 461 AEDHIGALRAVDPKTGKIMWE----------YKNKAPLWGGVLTTRGNLVFTGTPEGYLKAFDAKTGKELWKFQTGSGVV 530
Cdd:PRK11138   74 AADRAGLVKALDADTGKEIWSvdlsekdgwfSKNKSALLSGGVTVAGGKVYIGSEKGQVYALNAEDGEVAWQTKVAGEAL 153

                          90       100
                  ....*....|....*....|.
gi 1036422517 531 GSPVTweqdGEQYVAVMSGWG 551
Cdd:PRK11138  154 SRPVV----SDGLVLVHTSNG 170
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 84-219 1.76e-06

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 50.20  E-value: 1.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  84 RGQeSQPIVYDGVIYVTGSYSRLFAFDARNGEKLWEYNHRLPDG------IMpccDVVNRgAAIHGDKVIFATLDARLVA 157
Cdd:COG1520   173 RGT-SSPVIVGGAVLVGFANGKLVALDLANGQPLWEQRVAQPRGrtelerLV---DVDGT-PVVDGGVVYAVAYQGRLAA 247

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1036422517 158 LNRKTGKVIWNKmtadykaGYSATAAPIIVKNLVITGNSGgefgavGEVQARNVDTGELVWT 219
Cdd:COG1520   248 LDLRSGRVLWSR-------DLSSYTGLAVDGNNLYVTDDD------GRVWALDRRNGAELWK 296
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 88-198 3.45e-06

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 49.55  E-value: 3.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  88 SQPIVYDGVIYVTGSYSRLFAFDARNGEKLWEYNHRlpdgimpccdvVNRGAAIHGDKVIFATLDARLVALNRKTGKVIW 167
Cdd:TIGR03300 235 GDPVVDGGQVYAVSYQGRVAALDLRSGRVLWKRDAS-----------SYQGPAVDDNRLYVTDADGVVVALDRRSGSELW 303

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1036422517 168 NkmTADYKagYSATAAPIIVKNLVITGNSGG 198
Cdd:TIGR03300 304 K--NDELK--YRQLTAPAVLGGYLVVGDFEG 330
PQQ COG1520
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ...
 466-521 4.67e-06

Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441129 [Multi-domain]  Cd Length: 370  Bit Score: 49.04  E-value: 4.67e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 466 GALRAVDPKTGKIMWEYKNKAP---LWG-GVLTTRGNLVFTGTPEGYLKAFDAKTGKELW 521
Cdd:COG1520   147 GRVYALDAATGERLWSYQRPVPaltLRGtSSPVIVGGAVLVGFANGKLVALDLANGQPLW 206
PQQ_2 pfam13360
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
 466-529 3.50e-05

PQQ-like domain; This domain contains several repeats of the PQQ repeat.


Pssm-ID: 433144 [Multi-domain]  Cd Length: 233  Bit Score: 45.47  E-value: 3.50e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1036422517 466 GALRAVDPKTGKIMWEYKNKAPLwGGVLTTRGNLVFTGTPEGYLKAFDAKTGKELWKFQTGSGV 529
Cdd:pfam13360  43 GQLVALDAATGKLLWRQTLSGEV-LGAPLVAGGRVFVVAGDGSLIALDAADGRRLWSYQRSGEP 105
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 88-220 7.70e-05

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 45.31  E-value: 7.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  88 SQPIVYDGVIYVTGSYSRLFAFDARNGEKLWEYNHRLPDGIMpccdvvnRG---AAIHGDKVIFATLDARLVALNRKTGK 164
Cdd:PRK11138  154 SRPVVSDGLVLVHTSNGMLQALNESDGAVKWTVNLDVPSLTL-------RGesaPATAFGGAIVGGDNGRVSAVLMEQGQ 226

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1036422517 165 VIWNKMTADYKAGYSAT------AAPIIVKNLVITgnsggeFGAVGEVQARNVDTGELVWTR 220
Cdd:PRK11138  227 LIWQQRISQPTGATEIDrlvdvdTTPVVVGGVVYA------LAYNGNLVALDLRSGQIVWKR 282
PQQ smart00564
beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline ...
 90-121 4.33e-04

beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline quinone (PQQ) as cofactor, in Ire1p-like Ser/Thr kinases, and in prokaryotic dehydrogenases.


Pssm-ID: 128836 [Multi-domain]  Cd Length: 33  Bit Score: 37.90  E-value: 4.33e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1036422517   90 PIVYDGVIYVTGSYSRLFAFDARNGEKLWEYN 121
Cdd:smart00564   2 VVLSDGTVYVGSTDGTLYALDAKTGEILWTYK 33
PQQ smart00564
beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline ...
 497-523 7.51e-04

beta-propeller repeat; Beta-propeller repeat occurring in enzymes with pyrrolo-quinoline quinone (PQQ) as cofactor, in Ire1p-like Ser/Thr kinases, and in prokaryotic dehydrogenases.


Pssm-ID: 128836 [Multi-domain]  Cd Length: 33  Bit Score: 37.13  E-value: 7.51e-04
                           10        20
                   ....*....|....*....|....*..
gi 1036422517  497 GNLVFTGTPEGYLKAFDAKTGKELWKF 523
Cdd:smart00564   6 DGTVYVGSTDGTLYALDAKTGEILWTY 32
WD40 COG2319
WD40 repeat [General function prediction only];
417-566 8.67e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 8.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 417 MAYSPDTEMFYVPSNDWGMDIWNepiaykkgaayLGAGFTIKPIaEDHIGALRAV---------------------DPKT 475
Cdd:COG2319   126 VAFSPDGKTLASGSADGTVRLWD-----------LATGKLLRTL-TGHSGAVTSVafspdgkllasgsddgtvrlwDLAT 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 476 GKIMWEYKN-KAPLWGGVLTTRGNLVFTGTPEGYLKAFDAKTGKELWKFQTGSGVVGSpVTWEQDGeQYVAVmSGWGGAV 554
Cdd:COG2319   194 GKLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRS-VAFSPDG-RLLAS-GSADGTV 270

                         170
                  ....*....|....*
gi 1036422517 555 PLW---GGEVAKTFK 566
Cdd:COG2319   271 RLWdlaTGELLRTLT 285
assembly_YfgL TIGR03300
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ...
 88-198 1.56e-03

outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274511 [Multi-domain]  Cd Length: 377  Bit Score: 41.07  E-value: 1.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  88 SQPIVYDGVIYVTGSYSRLFAFDARNGEKLWEyNHRLpdgimpccdvVNR---GAAIHGDKVIFATLDARLVALNRKTGK 164
Cdd:TIGR03300 273 QGPAVDDNRLYVTDADGVVVALDRRSGSELWK-NDEL----------KYRqltAPAVLGGYLVVGDFEGYLHWLDRDDGS 341

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1036422517 165 VIwnkmtADYKAGYSA-TAAPIIVKN-LVITGNSGG 198
Cdd:TIGR03300 342 FV-----ARLKTDGSGiASPPVVVGDgLLVQTRDGD 372
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 88-198 2.60e-03

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 40.39  E-value: 2.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517  88 SQPIVYDGVIYVTGSYSRLFAFDARNGEKLWEYnhrlpdgimpccDVVNRG-----AAIHGDKVIFATLDARLVALNRKT 162
Cdd:cd10276   250 STSTDANGRVYVGDGEGSLYCLDASTGDELWSQ------------TVLLGRvlsspAIYVGVYIYVTDNAEGYLYCLKDN 317

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1036422517 163 GKVIWNKMTADYKAGysATAAPIIVKNLVITGNSGG 198
Cdd:cd10276   318 DGLTVARVEVDYSQY--ILQGPAVSDGWLYYGTDDG 351
Luminal_IRE1 cd09769
The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, ...
 144-167 3.00e-03

The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1; The Luminal domain is a dimerization domain present in Inositol-requiring protein 1 (IRE1), a serine/threonine protein kinase (STK) and a type I transmembrane protein that is localized in the endoplasmic reticulum (ER). IRE1, also called Endoplasmic reticulum (ER)-to-nucleus signaling protein (or ERN), is a kinase receptor that also contains an endoribonuclease domain in the cytoplasmic side. It plays roles in the signaling of the unfolded protein response (UPR), which is activated when protein misfolding is detected in the ER in order to decrease the synthesis of new proteins and increase the capacity of the ER to cope with the stress. IRE1 acts as an ER stress sensor and is the oldest and most conserved component of the UPR in eukaryotes. During ER stress, IRE1 dimerizes through its luminal domain and forms oligomers, allowing the kinase domain to undergo trans-autophosphorylation. This leads to a conformational change that stimulates its endoribonuclease activity and results in the cleavage of its mRNA substrate, HAC1 in yeast and Xbp1 in metazoans, promoting a splicing event that enables translation into a transcription factor which activates the UPR. Mammals contain two IRE1 proteins, IRE1alpha (or ERN1) and IRE1beta (or ERN2). IRE1alpha is expressed in all cells and tissues while IRE1beta is found only in intestinal epithelial cells.


Pssm-ID: 188875 [Multi-domain]  Cd Length: 295  Bit Score: 39.99  E-value: 3.00e-03
                          10        20
                  ....*....|....*....|....
gi 1036422517 144 DKVIFATLDARLVALNRKTGKVIW 167
Cdd:cd09769     2 DLLLVSTVDGGLHAVDRKTGKILW 25
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 480-549 5.27e-03

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 39.24  E-value: 5.27e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1036422517 480 WEYKNKAPLWGGVLTT---RGNLVFTGTPEGYLKAFDAKTGKELWKFQT-GSGVVGSPVTWEqDGEQYVAVMSG 549
Cdd:cd10276    18 WSKSVGNGGMAGIDLTpvvAGDMVYAADANGQVSAFNATTGKIIWETSLsGKGFLGGTPAVG-NGKIFVGTESG 90
BamB_YfgL cd10276
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ...
 343-527 6.51e-03

Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.


Pssm-ID: 199834 [Multi-domain]  Cd Length: 358  Bit Score: 39.24  E-value: 6.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 343 ADRNGYFYVLDRTNGRLLnatpfvmqpnWASKIDLKTgrpvynaenRPGAPGTAEKGKpvfatpSFLGGKNWMPMAYSPD 422
Cdd:cd10276    44 ADANGQVSAFNATTGKII----------WETSLSGKG---------FLGGTPAVGNGK------IFVGTESGYLYALDAK 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036422517 423 TemfyvpsndwGMDIWNE---------PIAYKKGAAYLGagftikpiaeDHIGALRAVDPKTGKIMWEYKNKAP---LWG 490
Cdd:cd10276    99 D----------GSELWRTevsdsqllsPPTYADGKIYVG----------TGDGRLYYCNAETGKVVWNRTSTAPelsLRG 158

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1036422517 491 G--VLTTRGNlVFTGTPEGYLKAFDAKTGKELWKFQTGS 527
Cdd:cd10276   159 GaaPVGAYDV-VFVGDGNGTVVALNTGTGVDIWEFSVSE 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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