Chain C, CREB-binding protein
Protein Classification
NCBD_CREBBP-p300_like domain-containing protein( domain architecture ID 10557169)
NCBD_CREBBP-p300_like domain-containing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Creb_binding | pfam09030 | Creb binding; The Creb binding domain assumes a structure comprising of three alpha-helices ... |
1-47 | 8.14e-21 | ||
Creb binding; The Creb binding domain assumes a structure comprising of three alpha-helices which pack in a bundle, exposing a hydrophobic groove between alpha-1 and alpha-3 within which complimentary domains found in the protein 'activator for thyroid hormone and retinoid receptors' (ACTR) can dock. Docking of these domains is required for the recruitment of RNA polymerase II and the basal transcription machinery. : Pssm-ID: 462659 [Multi-domain] Cd Length: 111 Bit Score: 77.18 E-value: 8.14e-21
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| Name | Accession | Description | Interval | E-value | ||
| Creb_binding | pfam09030 | Creb binding; The Creb binding domain assumes a structure comprising of three alpha-helices ... |
1-47 | 8.14e-21 | ||
Creb binding; The Creb binding domain assumes a structure comprising of three alpha-helices which pack in a bundle, exposing a hydrophobic groove between alpha-1 and alpha-3 within which complimentary domains found in the protein 'activator for thyroid hormone and retinoid receptors' (ACTR) can dock. Docking of these domains is required for the recruitment of RNA polymerase II and the basal transcription machinery. Pssm-ID: 462659 [Multi-domain] Cd Length: 111 Bit Score: 77.18 E-value: 8.14e-21
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| NCBD_CREBBP-p300_like | cd20910 | Nuclear Coactivator Binding Domain (NCBD) of CREB (cyclic AMP response element binding protein) ... |
2-44 | 1.00e-09 | ||
Nuclear Coactivator Binding Domain (NCBD) of CREB (cyclic AMP response element binding protein) binding protein (CREBBP, also known as CBP) and its paralog p300; CREBBP (also called CBP) and its paralog p300, generally referred to as CREBBP/p300, are universal transcriptional coactivators that interact with many important transcription factors and comodulators to activate transcription. The NCBD domain [nuclear coactivator binding domain, also known as IRF-3 binding domain (IBiD) or SRC1 interaction domain (SID)] of CREBBP/p300 behaves as an intrinsically disordered domain in isolation, but folds into helical structures with different topologies upon binding to different ligands such as nuclear receptor coactivator p160, CREBBP interaction domain (CID) from nuclear receptor coactivator 1 (NCOA1 or Src1), NCOA2 (Tif2), and NCOA3 (ACTR), or interferon regulatory factor 3 (IRF-3). In Drosophila, there is only one CREB-binding protein ortholog and it is called nejire, dCBP, CBP/p300, or CBP. Pssm-ID: 411021 [Multi-domain] Cd Length: 43 Bit Score: 47.26 E-value: 1.00e-09
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| Name | Accession | Description | Interval | E-value | ||
| Creb_binding | pfam09030 | Creb binding; The Creb binding domain assumes a structure comprising of three alpha-helices ... |
1-47 | 8.14e-21 | ||
Creb binding; The Creb binding domain assumes a structure comprising of three alpha-helices which pack in a bundle, exposing a hydrophobic groove between alpha-1 and alpha-3 within which complimentary domains found in the protein 'activator for thyroid hormone and retinoid receptors' (ACTR) can dock. Docking of these domains is required for the recruitment of RNA polymerase II and the basal transcription machinery. Pssm-ID: 462659 [Multi-domain] Cd Length: 111 Bit Score: 77.18 E-value: 8.14e-21
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| NCBD_CREBBP-p300_like | cd20910 | Nuclear Coactivator Binding Domain (NCBD) of CREB (cyclic AMP response element binding protein) ... |
2-44 | 1.00e-09 | ||
Nuclear Coactivator Binding Domain (NCBD) of CREB (cyclic AMP response element binding protein) binding protein (CREBBP, also known as CBP) and its paralog p300; CREBBP (also called CBP) and its paralog p300, generally referred to as CREBBP/p300, are universal transcriptional coactivators that interact with many important transcription factors and comodulators to activate transcription. The NCBD domain [nuclear coactivator binding domain, also known as IRF-3 binding domain (IBiD) or SRC1 interaction domain (SID)] of CREBBP/p300 behaves as an intrinsically disordered domain in isolation, but folds into helical structures with different topologies upon binding to different ligands such as nuclear receptor coactivator p160, CREBBP interaction domain (CID) from nuclear receptor coactivator 1 (NCOA1 or Src1), NCOA2 (Tif2), and NCOA3 (ACTR), or interferon regulatory factor 3 (IRF-3). In Drosophila, there is only one CREB-binding protein ortholog and it is called nejire, dCBP, CBP/p300, or CBP. Pssm-ID: 411021 [Multi-domain] Cd Length: 43 Bit Score: 47.26 E-value: 1.00e-09
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