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Conserved domains on  [gi|1035661761|ref|NP_056052|]
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BTB/POZ domain-containing protein 8 isoform 2 [Homo sapiens]

Protein Classification

APache family protein( domain architecture ID 10634040)

APache family protein is a DUF4596 domain-containing protein similar to Homo sapiens AP2-interacting clathrin-endocytosis protein (APache, also known as KIAA1107) that is involved in clathrin-mediated endocytosis at the synapse

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4596 pfam15363
Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is ...
 1236-1279 4.67e-18

Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is approximately 50 amino acids in length. There is a conserved ELET sequence motif. There are two completely conserved residues (S and E) that may be functionally important.


:

Pssm-ID: 464673  Cd Length: 46  Bit Score: 78.81  E-value: 4.67e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1035661761 1236 DTLNRWSELTSPLD-SSASITMASFSSEDC-SPQGEWTILELETQH 1279
Cdd:pfam15363    1 DTWSRWSELSSPLDdSSASITVTSFSPEDGcSPQGEWTILELETQH 46
 
Name Accession Description Interval E-value
DUF4596 pfam15363
Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is ...
 1236-1279 4.67e-18

Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is approximately 50 amino acids in length. There is a conserved ELET sequence motif. There are two completely conserved residues (S and E) that may be functionally important.


Pssm-ID: 464673  Cd Length: 46  Bit Score: 78.81  E-value: 4.67e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1035661761 1236 DTLNRWSELTSPLD-SSASITMASFSSEDC-SPQGEWTILELETQH 1279
Cdd:pfam15363    1 DTWSRWSELSSPLDdSSASITVTSFSPEDGcSPQGEWTILELETQH 46
 
Name Accession Description Interval E-value
DUF4596 pfam15363
Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is ...
 1236-1279 4.67e-18

Domain of unknown function (DUF4596); This domain family is found in eukaryotes, and is approximately 50 amino acids in length. There is a conserved ELET sequence motif. There are two completely conserved residues (S and E) that may be functionally important.


Pssm-ID: 464673  Cd Length: 46  Bit Score: 78.81  E-value: 4.67e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1035661761 1236 DTLNRWSELTSPLD-SSASITMASFSSEDC-SPQGEWTILELETQH 1279
Cdd:pfam15363    1 DTWSRWSELSSPLDdSSASITVTSFSPEDGcSPQGEWTILELETQH 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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