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Conserved domains on  [gi|1034662293|ref|XP_016869596|]
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RB1-inducible coiled-coil protein 1 isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ubl_RB1CC1 cd17060
ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) ...
2-76 4.07e-40

ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) and similar proteins; RB1CC1, also termed FAK family kinase-interacting protein of 200 kDa (FIP200), is the mammalian counterpart of the yeast Atg17 gene and functions as a component of the ULK1/Atg13/RB1CC1/Atg101 complex essential for induction of autophagy. RB1CC1 is a key signaling node to regulate cellular proliferation and differentiation. As a DNA-binding transcription factor, RB1CC1 has been implicated in the regulation of retinoblastoma 1 (RB1) expression. RB1CC1 contains a conserved ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, as well as a nuclear localization signal (KPRK), a leucine zipper motif and a coiled-coil structure.


:

Pssm-ID: 340580  Cd Length: 75  Bit Score: 142.70  E-value: 4.07e-40
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034662293    2 KLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNK 76
Cdd:cd17060      1 MLYVFLVNTGTMLTFDMSLAVQSVSDLKEAIEEKTKIPVEKQVLLVSGGESLDPDKRVSSYSAGTDTNPIFLFNK 75
ATG11 pfam10377
Autophagy-related protein 11; The function of this family is conflicting. In the fission yeast, ...
1439-1585 6.24e-28

Autophagy-related protein 11; The function of this family is conflicting. In the fission yeast, Schizosaccharomyces pombe, this protein has been shown to interact with the telomere cap complex and it is also required for dimerization and kinase activation of Atg1. However, in budding yeast, Saccharomyces cerevisiae, this protein is called ATG11 and is shown to be involved in autophagy.


:

Pssm-ID: 463063  Cd Length: 130  Bit Score: 110.00  E-value: 6.24e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1439 ETSMMSVQENIHMLS-----EEKQRIMLLERTLQLKEEenkrlnqrlmsqsmssvssrhseKIAIRDFQVGDLVLIILDE 1513
Cdd:pfam10377    1 ESAVIKRFKDVETLAkkltkENKSKREKLEKLQSEAHE-----------------------KITLKNFKVGDLALFLPTR 57
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1514 RHDN-----YVLFTVSPTLYFLHSESLPALdlkpasgaSRRPWVLGKVMEKEYCQAK---KAQNRFKVPLGTKFYRVKAV 1585
Cdd:pfam10377   58 RHNDlstppWAAFNVGAPHYFLKADSLLAL--------KSREWFVGRITSIEERVVDlsdKDSNPFKLSKGTVWYLVTAE 129
Mplasa_alph_rch super family cl37461
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
871-1375 6.64e-19

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


The actual alignment was detected with superfamily member TIGR04523:

Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 93.16  E-value: 6.64e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  871 KNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAvicLQNEKDQKLLEMENIMHsqncEIKE 950
Cdd:TIGR04523  119 KNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEE---LENELNLLEKEKLNIQK----NIDK 191
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  951 LKQSR---EIVLEDLKKLhvenDEKLQLLRAELQSLEQ--SHLKELEDTLQVRhIQEFEKVMTDHRVSLEELKKENQQII 1025
Cdd:TIGR04523  192 IKNKLlklELLLSNLKKK----IQKNKSLESQISELKKqnNQLKDNIEKKQQE-INEKTTEISNTQTQLNQLKDEQNKIK 266
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1026 NQIQESHAEI------IQEKEKQLQELKLKVSDLSdtrcklevelalKEAETDEIKILLEESRAQQKetlkslleqETEN 1099
Cdd:TIGR04523  267 KQLSEKQKELeqnnkkIKELEKQLNQLKSEISDLN------------NQKEQDWNKELKSELKNQEK---------KLEE 325
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1100 LRTEISKLNQKIQDNNEnyqvglaelrTLMTIEKDqcISELISRHEEESNILKAELNKVTSLHNQ---AFEIEKNLKEQI 1176
Cdd:TIGR04523  326 IQNQISQNNKIISQLNE----------QISQLKKE--LTNSESENSEKQRELEEKQNEIEKLKKEnqsYKQEIKNLESQI 393
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1177 IELQSKLDsELSALERQKDEKITQQEEKYEAI---IQNLEKDRQKLVS------SQEQDREQLIQKLNCEKDEaIQTALK 1247
Cdd:TIGR04523  394 NDLESKIQ-NQEKLNQQKDEQIKKLQQEKELLekeIERLKETIIKNNSeikdltNQDSVKELIIKNLDNTRES-LETQLK 471
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1248 EFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKfLEQLEEQEKRKNEEMQNVRTSLIAE 1327
Cdd:TIGR04523  472 VLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEK-IEKLESEKKEKESKISDLEDELNKD 550
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*...
gi 1034662293 1328 QQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDR 1375
Cdd:TIGR04523  551 DFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEK 598
ATG17_like super family cl27196
Autophagy protein ATG17-like domain; This domain is found in the autophagy-related proteins ...
404-538 1.44e-03

Autophagy protein ATG17-like domain; This domain is found in the autophagy-related proteins ATG17 and ATG11, conserved across eukaryotes. ATG17 forms a complex with ATG29 and ATG31, critical for both PAS (preautophagosomal structure) formation and autophagy. Together with ATG13, it is required for ATG1 kinase activation. ATG11 is a scaffold protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway during starvation and to recruit ATG proteins to the pre-autophagosome. It is also required for ATG1 kinase activation. In many eukaryotes, ATG11 (the orthologue in mammals is RB1-inducible coiled-coil protein 1 (RB1CC1) and in S. pombe is Taz1-interacting factor 1 (taf1)) is essential for bulk autophagy, except in S.cerevisiae. ATG17 and ATG11 are large similar proteins, both predicted to be almost entirely helical, containing conserved coiled-coil regions and lack obvious functional motifs.


The actual alignment was detected with superfamily member pfam04108:

Pssm-ID: 427715 [Multi-domain]  Cd Length: 360  Bit Score: 42.76  E-value: 1.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  404 KDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANNLHV------RLKWCCFVMLHADQDGEKLQALLRLVI 477
Cdd:pfam04108  214 NDARELDDVVPELQDRLDEMENNYERLQKLLEQKNSLIDELLSALQLiaeiqsRLPEYLAALKEFEERWEEEKETIEDYL 293
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034662293  478 ELLERVkiVEALSTVPQMYCLAVVEVVRRKMFIKHYREWAGALVKDGKRLYEAEKSKRESF 538
Cdd:pfam04108  294 SELEDL--REFYEGFPSAYGSLLLEVERRREWAEKMKKILRKLAEELDRLQEEERKRREKF 352
 
Name Accession Description Interval E-value
Ubl_RB1CC1 cd17060
ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) ...
2-76 4.07e-40

ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) and similar proteins; RB1CC1, also termed FAK family kinase-interacting protein of 200 kDa (FIP200), is the mammalian counterpart of the yeast Atg17 gene and functions as a component of the ULK1/Atg13/RB1CC1/Atg101 complex essential for induction of autophagy. RB1CC1 is a key signaling node to regulate cellular proliferation and differentiation. As a DNA-binding transcription factor, RB1CC1 has been implicated in the regulation of retinoblastoma 1 (RB1) expression. RB1CC1 contains a conserved ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, as well as a nuclear localization signal (KPRK), a leucine zipper motif and a coiled-coil structure.


Pssm-ID: 340580  Cd Length: 75  Bit Score: 142.70  E-value: 4.07e-40
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034662293    2 KLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNK 76
Cdd:cd17060      1 MLYVFLVNTGTMLTFDMSLAVQSVSDLKEAIEEKTKIPVEKQVLLVSGGESLDPDKRVSSYSAGTDTNPIFLFNK 75
ATG11 pfam10377
Autophagy-related protein 11; The function of this family is conflicting. In the fission yeast, ...
1439-1585 6.24e-28

Autophagy-related protein 11; The function of this family is conflicting. In the fission yeast, Schizosaccharomyces pombe, this protein has been shown to interact with the telomere cap complex and it is also required for dimerization and kinase activation of Atg1. However, in budding yeast, Saccharomyces cerevisiae, this protein is called ATG11 and is shown to be involved in autophagy.


Pssm-ID: 463063  Cd Length: 130  Bit Score: 110.00  E-value: 6.24e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1439 ETSMMSVQENIHMLS-----EEKQRIMLLERTLQLKEEenkrlnqrlmsqsmssvssrhseKIAIRDFQVGDLVLIILDE 1513
Cdd:pfam10377    1 ESAVIKRFKDVETLAkkltkENKSKREKLEKLQSEAHE-----------------------KITLKNFKVGDLALFLPTR 57
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1514 RHDN-----YVLFTVSPTLYFLHSESLPALdlkpasgaSRRPWVLGKVMEKEYCQAK---KAQNRFKVPLGTKFYRVKAV 1585
Cdd:pfam10377   58 RHNDlstppWAAFNVGAPHYFLKADSLLAL--------KSREWFVGRITSIEERVVDlsdKDSNPFKLSKGTVWYLVTAE 129
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
871-1375 6.64e-19

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 93.16  E-value: 6.64e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  871 KNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAvicLQNEKDQKLLEMENIMHsqncEIKE 950
Cdd:TIGR04523  119 KNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEE---LENELNLLEKEKLNIQK----NIDK 191
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  951 LKQSR---EIVLEDLKKLhvenDEKLQLLRAELQSLEQ--SHLKELEDTLQVRhIQEFEKVMTDHRVSLEELKKENQQII 1025
Cdd:TIGR04523  192 IKNKLlklELLLSNLKKK----IQKNKSLESQISELKKqnNQLKDNIEKKQQE-INEKTTEISNTQTQLNQLKDEQNKIK 266
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1026 NQIQESHAEI------IQEKEKQLQELKLKVSDLSdtrcklevelalKEAETDEIKILLEESRAQQKetlkslleqETEN 1099
Cdd:TIGR04523  267 KQLSEKQKELeqnnkkIKELEKQLNQLKSEISDLN------------NQKEQDWNKELKSELKNQEK---------KLEE 325
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1100 LRTEISKLNQKIQDNNEnyqvglaelrTLMTIEKDqcISELISRHEEESNILKAELNKVTSLHNQ---AFEIEKNLKEQI 1176
Cdd:TIGR04523  326 IQNQISQNNKIISQLNE----------QISQLKKE--LTNSESENSEKQRELEEKQNEIEKLKKEnqsYKQEIKNLESQI 393
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1177 IELQSKLDsELSALERQKDEKITQQEEKYEAI---IQNLEKDRQKLVS------SQEQDREQLIQKLNCEKDEaIQTALK 1247
Cdd:TIGR04523  394 NDLESKIQ-NQEKLNQQKDEQIKKLQQEKELLekeIERLKETIIKNNSeikdltNQDSVKELIIKNLDNTRES-LETQLK 471
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1248 EFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKfLEQLEEQEKRKNEEMQNVRTSLIAE 1327
Cdd:TIGR04523  472 VLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEK-IEKLESEKKEKESKISDLEDELNKD 550
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*...
gi 1034662293 1328 QQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDR 1375
Cdd:TIGR04523  551 DFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEK 598
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
855-1376 1.11e-13

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 76.51  E-value: 1.11e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  855 LEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKL 934
Cdd:COG1196    218 LKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAEL 297
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  935 LEMENimhsqncEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSL 1014
Cdd:COG1196    298 ARLEQ-------DIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEA 370
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1015 EELKKENQQIINQIQESHAEIIQ---EKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKS 1091
Cdd:COG1196    371 EAELAEAEEELEELAEELLEALRaaaELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEE 450
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1092 LLEQETEN---------LRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKD---------------------QCISELI 1141
Cdd:COG1196    451 EAELEEEEeallellaeLLEEAALLEAALAELLEELAEAAARLLLLLEAEADyegflegvkaalllaglrglaGAVAVLI 530
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1142 SRHEEESNILKAELNKVtsLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVS 1221
Cdd:COG1196    531 GVEAAYEAALEAALAAA--LQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDL 608
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1222 SQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAK 1301
Cdd:COG1196    609 READARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERL 688
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034662293 1302 FLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRA 1376
Cdd:COG1196    689 AEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLE 763
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
859-1377 3.57e-13

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 74.77  E-value: 3.57e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  859 LKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVIC-LQNE-------K 930
Cdd:pfam15921  261 LLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSqLRSElreakrmY 340
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  931 DQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLhvenDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDH 1010
Cdd:pfam15921  341 EDKIEELEKQLVLANSELTEARTERDQFSQESGNL----DDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDH 416
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1011 -RVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDL---SDTRCKLEVELALKEAETDEI---KILLEESRA 1083
Cdd:pfam15921  417 lRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKNESLekvSSLTAQLESTKEMLRKVVEELtakKMTLESSER 496
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1084 QQKETLKSLLEQE--TENLRTEISKLNQKI-------------QDNNENYQVGLAELRTLMTiEKDQCISELISRHEEES 1148
Cdd:pfam15921  497 TVSDLTASLQEKEraIEATNAEITKLRSRVdlklqelqhlkneGDHLRNVQTECEALKLQMA-EKDKVIEILRQQIENMT 575
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1149 NILKAELNKVTSLHNQAFEIEKNLKEQIIELQskldsELSALERQKDEKITQQEEKyeaiIQNLEKDRQKLVSSQ----- 1223
Cdd:pfam15921  576 QLVGQHGRTAGAMQVEKAQLEKEINDRRLELQ-----EFKILKDKKDAKIRELEAR----VSDLELEKVKLVNAGserlr 646
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1224 -----EQDREQLIQKL-NCEKD--------EAIQTALKEFKLEREVVEKELLEKVKHLENQIAKS----PAIDSTRGDSS 1285
Cdd:pfam15921  647 avkdiKQERDQLLNEVkTSRNElnslsedyEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTrntlKSMEGSDGHAM 726
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1286 SLVAELQEKLQ---------EEKAKFLEQ-----------LEEQEKRKNEEMQNVRTSLiAEQQTNFNTVLTREKMRKEN 1345
Cdd:pfam15921  727 KVAMGMQKQITakrgqidalQSKIQFLEEamtnankekhfLKEEKNKLSQELSTVATEK-NKMAGELEVLRSQERRLKEK 805
                          570       580       590
                   ....*....|....*....|....*....|..
gi 1034662293 1346 IINDLSDKLKSTMQQQERdKDLIESLSEDRAR 1377
Cdd:pfam15921  806 VANMEVALDKASLQFAEC-QDIIQRQEQESVR 836
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
843-1377 1.22e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 73.17  E-value: 1.22e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  843 EIRNIIEK-------VKCSLEITLKEKHQKELLSLKNEYEGKLDGL---IKETEENENKIKKLKGELVCLEEVLQNKDNE 912
Cdd:PRK03918   136 EIDAILESdesrekvVRQILGLDDYENAYKNLGEVIKEIKRRIERLekfIKRTENIEELIKEKEKELEEVLREINEISSE 215
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  913 FALVKHEKEAViclqnekDQKLLEMENIMHsqncEIKELKQSREIVLEDLKKLhvenDEKLQLLRAELQSLEqSHLKELE 992
Cdd:PRK03918   216 LPELREELEKL-------EKEVKELEELKE----EIEELEKELESLEGSKRKL----EEKIRELEERIEELK-KEIEELE 279
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  993 DtlQVRHIQEFEKVMTDHRvSLEELKKENQQIINQIQ---ESHAEIIQEKEKQLQELKLKVSDLSDTRCKLE------VE 1063
Cdd:PRK03918   280 E--KVKELKELKEKAEEYI-KLSEFYEEYLDELREIEkrlSRLEEEINGIEERIKELEEKEERLEELKKKLKelekrlEE 356
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1064 LALKEAETDEIKILLEESRAQQK-----------------ETLKSLLEQETENLRTEISKLNQKIQDNNENyqvgLAELR 1126
Cdd:PRK03918   357 LEERHELYEEAKAKKEELERLKKrltgltpeklekeleelEKAKEEIEEEISKITARIGELKKEIKELKKA----IEELK 432
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1127 TlMTIEKDQCISELISRHEEE-SNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKL--DSELSALeRQKDEKITQQEE 1203
Cdd:PRK03918   433 K-AKGKCPVCGRELTEEHRKElLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLkkESELIKL-KELAEQLKELEE 510
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1204 KYEAIiqNLEKDRQKlvssqEQDREQLIQKLNCEKDEaIQTALKEFKLEREVVEK--ELLEKVKHLENQIAKSPAIDSTR 1281
Cdd:PRK03918   511 KLKKY--NLEELEKK-----AEEYEKLKEKLIKLKGE-IKSLKKELEKLEELKKKlaELEKKLDELEEELAELLKELEEL 582
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1282 GDSSslVAELQEKLQEEKAKFLEQLE----EQEKRKNEEMQNVRTSLIAEQQTNFNTVLTR-EKMRKEniINDLsdKLKS 1356
Cdd:PRK03918   583 GFES--VEELEERLKELEPFYNEYLElkdaEKELEREEKELKKLEEELDKAFEELAETEKRlEELRKE--LEEL--EKKY 656
                          570       580
                   ....*....|....*....|.
gi 1034662293 1357 TMQQQERDKDLIESLSEDRAR 1377
Cdd:PRK03918   657 SEEEYEELREEYLELSRELAG 677
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
886-1059 2.44e-04

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 44.36  E-value: 2.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  886 EENENKIKKLKGelvcLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKL 965
Cdd:cd00176     33 ESVEALLKKHEA----LEAELAAHEERVEALNELGEQLIEEGHPDAEEIQERLEELNQRWEELRELAEERRQRLEEALDL 108
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  966 HVENDEKLQLL----RAELQSLEQSHLKELED-TLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKE 1040
Cdd:cd00176    109 QQFFRDADDLEqwleEKEAALASEDLGKDLESvEELLKKHKELEEELEAHEPRLKSLNELAEELLEEGHPDADEEIEEKL 188
                          170
                   ....*....|....*....
gi 1034662293 1041 KQLQELKLKVSDLSDTRCK 1059
Cdd:cd00176    189 EELNERWEELLELAEERQK 207
OmpH smart00935
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
1186-1273 8.88e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 214922 [Multi-domain]  Cd Length: 140  Bit Score: 41.03  E-value: 8.88e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  1186 ELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVK 1265
Cdd:smart00935   22 QLEKEFKKRQAELEKLEKELQKLKEKLQKDAATLSEAAREKKEKELQKKVQEFQRKQQKLQQDLQKRQQEELQKILDKIN 101

                    ....*...
gi 1034662293  1266 HLENQIAK 1273
Cdd:smart00935  102 KAIKEVAK 109
ATG17_like pfam04108
Autophagy protein ATG17-like domain; This domain is found in the autophagy-related proteins ...
404-538 1.44e-03

Autophagy protein ATG17-like domain; This domain is found in the autophagy-related proteins ATG17 and ATG11, conserved across eukaryotes. ATG17 forms a complex with ATG29 and ATG31, critical for both PAS (preautophagosomal structure) formation and autophagy. Together with ATG13, it is required for ATG1 kinase activation. ATG11 is a scaffold protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway during starvation and to recruit ATG proteins to the pre-autophagosome. It is also required for ATG1 kinase activation. In many eukaryotes, ATG11 (the orthologue in mammals is RB1-inducible coiled-coil protein 1 (RB1CC1) and in S. pombe is Taz1-interacting factor 1 (taf1)) is essential for bulk autophagy, except in S.cerevisiae. ATG17 and ATG11 are large similar proteins, both predicted to be almost entirely helical, containing conserved coiled-coil regions and lack obvious functional motifs.


Pssm-ID: 427715 [Multi-domain]  Cd Length: 360  Bit Score: 42.76  E-value: 1.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  404 KDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANNLHV------RLKWCCFVMLHADQDGEKLQALLRLVI 477
Cdd:pfam04108  214 NDARELDDVVPELQDRLDEMENNYERLQKLLEQKNSLIDELLSALQLiaeiqsRLPEYLAALKEFEERWEEEKETIEDYL 293
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034662293  478 ELLERVkiVEALSTVPQMYCLAVVEVVRRKMFIKHYREWAGALVKDGKRLYEAEKSKRESF 538
Cdd:pfam04108  294 SELEDL--REFYEGFPSAYGSLLLEVERRREWAEKMKKILRKLAEELDRLQEEERKRREKF 352
 
Name Accession Description Interval E-value
Ubl_RB1CC1 cd17060
ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) ...
2-76 4.07e-40

ubiquitin-like (Ubl) domain found in retinoblastoma 1-inducible coiled-coil protein 1 (RB1CC1) and similar proteins; RB1CC1, also termed FAK family kinase-interacting protein of 200 kDa (FIP200), is the mammalian counterpart of the yeast Atg17 gene and functions as a component of the ULK1/Atg13/RB1CC1/Atg101 complex essential for induction of autophagy. RB1CC1 is a key signaling node to regulate cellular proliferation and differentiation. As a DNA-binding transcription factor, RB1CC1 has been implicated in the regulation of retinoblastoma 1 (RB1) expression. RB1CC1 contains a conserved ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, as well as a nuclear localization signal (KPRK), a leucine zipper motif and a coiled-coil structure.


Pssm-ID: 340580  Cd Length: 75  Bit Score: 142.70  E-value: 4.07e-40
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034662293    2 KLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNK 76
Cdd:cd17060      1 MLYVFLVNTGTMLTFDMSLAVQSVSDLKEAIEEKTKIPVEKQVLLVSGGESLDPDKRVSSYSAGTDTNPIFLFNK 75
ATG11 pfam10377
Autophagy-related protein 11; The function of this family is conflicting. In the fission yeast, ...
1439-1585 6.24e-28

Autophagy-related protein 11; The function of this family is conflicting. In the fission yeast, Schizosaccharomyces pombe, this protein has been shown to interact with the telomere cap complex and it is also required for dimerization and kinase activation of Atg1. However, in budding yeast, Saccharomyces cerevisiae, this protein is called ATG11 and is shown to be involved in autophagy.


Pssm-ID: 463063  Cd Length: 130  Bit Score: 110.00  E-value: 6.24e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1439 ETSMMSVQENIHMLS-----EEKQRIMLLERTLQLKEEenkrlnqrlmsqsmssvssrhseKIAIRDFQVGDLVLIILDE 1513
Cdd:pfam10377    1 ESAVIKRFKDVETLAkkltkENKSKREKLEKLQSEAHE-----------------------KITLKNFKVGDLALFLPTR 57
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1514 RHDN-----YVLFTVSPTLYFLHSESLPALdlkpasgaSRRPWVLGKVMEKEYCQAK---KAQNRFKVPLGTKFYRVKAV 1585
Cdd:pfam10377   58 RHNDlstppWAAFNVGAPHYFLKADSLLAL--------KSREWFVGRITSIEERVVDlsdKDSNPFKLSKGTVWYLVTAE 129
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
871-1375 6.64e-19

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 93.16  E-value: 6.64e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  871 KNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAvicLQNEKDQKLLEMENIMHsqncEIKE 950
Cdd:TIGR04523  119 KNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEE---LENELNLLEKEKLNIQK----NIDK 191
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  951 LKQSR---EIVLEDLKKLhvenDEKLQLLRAELQSLEQ--SHLKELEDTLQVRhIQEFEKVMTDHRVSLEELKKENQQII 1025
Cdd:TIGR04523  192 IKNKLlklELLLSNLKKK----IQKNKSLESQISELKKqnNQLKDNIEKKQQE-INEKTTEISNTQTQLNQLKDEQNKIK 266
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1026 NQIQESHAEI------IQEKEKQLQELKLKVSDLSdtrcklevelalKEAETDEIKILLEESRAQQKetlkslleqETEN 1099
Cdd:TIGR04523  267 KQLSEKQKELeqnnkkIKELEKQLNQLKSEISDLN------------NQKEQDWNKELKSELKNQEK---------KLEE 325
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1100 LRTEISKLNQKIQDNNEnyqvglaelrTLMTIEKDqcISELISRHEEESNILKAELNKVTSLHNQ---AFEIEKNLKEQI 1176
Cdd:TIGR04523  326 IQNQISQNNKIISQLNE----------QISQLKKE--LTNSESENSEKQRELEEKQNEIEKLKKEnqsYKQEIKNLESQI 393
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1177 IELQSKLDsELSALERQKDEKITQQEEKYEAI---IQNLEKDRQKLVS------SQEQDREQLIQKLNCEKDEaIQTALK 1247
Cdd:TIGR04523  394 NDLESKIQ-NQEKLNQQKDEQIKKLQQEKELLekeIERLKETIIKNNSeikdltNQDSVKELIIKNLDNTRES-LETQLK 471
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1248 EFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKfLEQLEEQEKRKNEEMQNVRTSLIAE 1327
Cdd:TIGR04523  472 VLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEK-IEKLESEKKEKESKISDLEDELNKD 550
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*...
gi 1034662293 1328 QQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDR 1375
Cdd:TIGR04523  551 DFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEK 598
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
856-1363 2.27e-14

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 78.94  E-value: 2.27e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  856 EITLKEKHQKELLSLKNEYEGKLDGLIKETEENE--NKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQK 933
Cdd:TIGR00606  492 KNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEqlNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYFPN 571
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  934 LLEMENIMHSQNCEIKELKQSreivLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVS 1013
Cdd:TIGR00606  572 KKQLEDWLHSKSKEINQTRDR----LAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVCGSQDEESDLERLKEE 647
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1014 LEELKKEN----------QQIINQIQESHA------EIIQEKEKQLQE----LKLKVSDLSDTRCKLEVELALKEAETDE 1073
Cdd:TIGR00606  648 IEKSSKQRamlagatavySQFITQLTDENQsccpvcQRVFQTEAELQEfisdLQSKLRLAPDKLKSTESELKKKEKRRDE 727
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1074 IKILLEesraqQKETLKSLLEQETENLRTEISKLNQKIQDNNENyqvglaelrtlmtIEKDQCISELISRHEEESNILKA 1153
Cdd:TIGR00606  728 MLGLAP-----GRQSIIDLKEKEIPELRNKLQKVNRDIQRLKND-------------IEEQETLLGTIMPEEESAKVCLT 789
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1154 ELNKVTSLHNQAFEIEKNLKEQIIELQSkldSELSALERQKDEKITQQEEKYEAIIQNLEKDRqKLVSSQEQDREQLIQK 1233
Cdd:TIGR00606  790 DVTIMERFQMELKDVERKIAQQAAKLQG---SDLDRTVQQVNQEKQEKQHELDTVVSKIELNR-KLIQDQQEQIQHLKSK 865
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1234 LNCEKDEAIQtaLKEFKLEREVVEKELLEKVKHLENQIAkspAIDSTRGDSSSLvAELQEKLQEEKAKFLEQLEEQEKRK 1313
Cdd:TIGR00606  866 TNELKSEKLQ--IGTNLQRRQQFEEQLVELSTEVQSLIR---EIKDAKEQDSPL-ETFLEKDQQEKEELISSKETSNKKA 939
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034662293 1314 NEEMQNVRTSL---IAEQQTNFNTV---LTREKMRKENIINDLSDKLKSTMQQQER 1363
Cdd:TIGR00606  940 QDKVNDIKEKVkniHGYMKDIENKIqdgKDDYLKQKETELNTVNAQLEECEKHQEK 995
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
855-1376 1.11e-13

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 76.51  E-value: 1.11e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  855 LEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKL 934
Cdd:COG1196    218 LKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAEL 297
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  935 LEMENimhsqncEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSL 1014
Cdd:COG1196    298 ARLEQ-------DIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEA 370
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1015 EELKKENQQIINQIQESHAEIIQ---EKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKS 1091
Cdd:COG1196    371 EAELAEAEEELEELAEELLEALRaaaELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEE 450
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1092 LLEQETEN---------LRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKD---------------------QCISELI 1141
Cdd:COG1196    451 EAELEEEEeallellaeLLEEAALLEAALAELLEELAEAAARLLLLLEAEADyegflegvkaalllaglrglaGAVAVLI 530
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1142 SRHEEESNILKAELNKVtsLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVS 1221
Cdd:COG1196    531 GVEAAYEAALEAALAAA--LQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDL 608
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1222 SQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAK 1301
Cdd:COG1196    609 READARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERL 688
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034662293 1302 FLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRA 1376
Cdd:COG1196    689 AEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLE 763
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1035-1362 1.52e-13

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 76.13  E-value: 1.52e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1035 IIQEKEKQLQELK------LKVSDLSDTRCKLEVELAL-------KEAETDEIKILLEESRAQQKETLKSLLEQETENLR 1101
Cdd:COG1196    194 ILGELERQLEPLErqaekaERYRELKEELKELEAELLLlklreleAELEELEAELEELEAELEELEAELAELEAELEELR 273
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1102 TEISKLNQKIQDNNENYQVGLAElrtlmtiekdqciselISRHEEESNILKAELnkvtslhnqafeieKNLKEQIIELQS 1181
Cdd:COG1196    274 LELEELELELEEAQAEEYELLAE----------------LARLEQDIARLEERR--------------RELEERLEELEE 323
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1182 KLDSELSALERQKDEKITQQEEK--YEAIIQNLEKDRQKLVSSQEQDREQLIQKLncEKDEAIQTALKEFKLEREVVEKE 1259
Cdd:COG1196    324 ELAELEEELEELEEELEELEEELeeAEEELEEAEAELAEAEEALLEAEAELAEAE--EELEELAEELLEALRAAAELAAQ 401
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1260 LLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTRE 1339
Cdd:COG1196    402 LEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAE 481
                          330       340
                   ....*....|....*....|...
gi 1034662293 1340 KMRKENIINDLSDKLKSTMQQQE 1362
Cdd:COG1196    482 LLEELAEAAARLLLLLEAEADYE 504
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
859-1377 3.57e-13

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 74.77  E-value: 3.57e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  859 LKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVIC-LQNE-------K 930
Cdd:pfam15921  261 LLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSqLRSElreakrmY 340
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  931 DQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLhvenDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDH 1010
Cdd:pfam15921  341 EDKIEELEKQLVLANSELTEARTERDQFSQESGNL----DDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDH 416
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1011 -RVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDL---SDTRCKLEVELALKEAETDEI---KILLEESRA 1083
Cdd:pfam15921  417 lRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKNESLekvSSLTAQLESTKEMLRKVVEELtakKMTLESSER 496
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1084 QQKETLKSLLEQE--TENLRTEISKLNQKI-------------QDNNENYQVGLAELRTLMTiEKDQCISELISRHEEES 1148
Cdd:pfam15921  497 TVSDLTASLQEKEraIEATNAEITKLRSRVdlklqelqhlkneGDHLRNVQTECEALKLQMA-EKDKVIEILRQQIENMT 575
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1149 NILKAELNKVTSLHNQAFEIEKNLKEQIIELQskldsELSALERQKDEKITQQEEKyeaiIQNLEKDRQKLVSSQ----- 1223
Cdd:pfam15921  576 QLVGQHGRTAGAMQVEKAQLEKEINDRRLELQ-----EFKILKDKKDAKIRELEAR----VSDLELEKVKLVNAGserlr 646
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1224 -----EQDREQLIQKL-NCEKD--------EAIQTALKEFKLEREVVEKELLEKVKHLENQIAKS----PAIDSTRGDSS 1285
Cdd:pfam15921  647 avkdiKQERDQLLNEVkTSRNElnslsedyEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTrntlKSMEGSDGHAM 726
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1286 SLVAELQEKLQ---------EEKAKFLEQ-----------LEEQEKRKNEEMQNVRTSLiAEQQTNFNTVLTREKMRKEN 1345
Cdd:pfam15921  727 KVAMGMQKQITakrgqidalQSKIQFLEEamtnankekhfLKEEKNKLSQELSTVATEK-NKMAGELEVLRSQERRLKEK 805
                          570       580       590
                   ....*....|....*....|....*....|..
gi 1034662293 1346 IINDLSDKLKSTMQQQERdKDLIESLSEDRAR 1377
Cdd:pfam15921  806 VANMEVALDKASLQFAEC-QDIIQRQEQESVR 836
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
926-1315 6.83e-13

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 73.95  E-value: 6.83e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  926 LQNEKD---QKLLEMENIMHSQNCEIKELKQS---REIVLEDLKKLHVENDEKLQLLRAELQSLEQ--SHLKELEDTLQV 997
Cdd:TIGR02169  686 LKRELSslqSELRRIENRLDELSQELSDASRKigeIEKEIEQLEQEEEKLKERLEELEEDLSSLEQeiENVKSELKELEA 765
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  998 RhIQEFEKVMTDHRVSLEELK-KENQQIINQIQEShaeiIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKI 1076
Cdd:TIGR02169  766 R-IEELEEDLHKLEEALNDLEaRLSHSRIPEIQAE----LSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQE 840
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1077 LLEESRAQQKEtlkslLEQETENLRTEISKLNQKIqdnnENYQVGLAELRT-LMTIEKDqciselISRHEEEsniLKAEL 1155
Cdd:TIGR02169  841 QRIDLKEQIKS-----IEKEIENLNGKKEELEEEL----EELEAALRDLESrLGDLKKE------RDELEAQ---LRELE 902
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1156 NKVTSLHNQAFEIEKNLKEQIIELQSKLDsELSALERQKDEKITQQEEkyEAIIQNLEKDRQKLvssqeqdrEQLIQKLN 1235
Cdd:TIGR02169  903 RKIEELEAQIEKKRKRLSELKAKLEALEE-ELSEIEDPKGEDEEIPEE--ELSLEDVQAELQRV--------EEEIRALE 971
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1236 CEKDEAIQtalkefklEREVVEKELLEkvkhlenqiakspaidstrgdssslVAELQEKLQEEKAKFLEQLEEQEKRKNE 1315
Cdd:TIGR02169  972 PVNMLAIQ--------EYEEVLKRLDE-------------------------LKEKRAKLEEERKAILERIEEYEKKKRE 1018
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
953-1272 6.98e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 73.94  E-value: 6.98e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  953 QSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSH--LKELEDTLQVRhIQEFEKVMTDHRVSLEELKKENQQIINQIQE 1030
Cdd:TIGR02168  673 LERRREIEELEEKIEELEEKIAELEKALAELRKELeeLEEELEQLRKE-LEELSRQISALRKDLARLEAEVEQLEERIAQ 751
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1031 SHAEiIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKEtlkslLEQETENLRTEISKLNQK 1110
Cdd:TIGR02168  752 LSKE-LTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDE-----LRAELTLLNEEAANLRER 825
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1111 IQDNnenyqvglaELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSL---HNQAFEIEKNLKEQIIELQSKLDSEL 1187
Cdd:TIGR02168  826 LESL---------ERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELieeLESELEALLNERASLEEALALLRSEL 896
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1188 SALERQKDEKitqqEEKYEAIIQNLEKDRQKLVSSQ------EQDREQLIQKLNcEKDEAIQTALKEFKLEREVVEKELL 1261
Cdd:TIGR02168  897 EELSEELREL----ESKRSELRRELEELREKLAQLElrleglEVRIDNLQERLS-EEYSLTLEEAEALENKIEDDEEEAR 971
                          330
                   ....*....|.
gi 1034662293 1262 EKVKHLENQIA 1272
Cdd:TIGR02168  972 RRLKRLENKIK 982
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
843-1377 1.22e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 73.17  E-value: 1.22e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  843 EIRNIIEK-------VKCSLEITLKEKHQKELLSLKNEYEGKLDGL---IKETEENENKIKKLKGELVCLEEVLQNKDNE 912
Cdd:PRK03918   136 EIDAILESdesrekvVRQILGLDDYENAYKNLGEVIKEIKRRIERLekfIKRTENIEELIKEKEKELEEVLREINEISSE 215
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  913 FALVKHEKEAViclqnekDQKLLEMENIMHsqncEIKELKQSREIVLEDLKKLhvenDEKLQLLRAELQSLEqSHLKELE 992
Cdd:PRK03918   216 LPELREELEKL-------EKEVKELEELKE----EIEELEKELESLEGSKRKL----EEKIRELEERIEELK-KEIEELE 279
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  993 DtlQVRHIQEFEKVMTDHRvSLEELKKENQQIINQIQ---ESHAEIIQEKEKQLQELKLKVSDLSDTRCKLE------VE 1063
Cdd:PRK03918   280 E--KVKELKELKEKAEEYI-KLSEFYEEYLDELREIEkrlSRLEEEINGIEERIKELEEKEERLEELKKKLKelekrlEE 356
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1064 LALKEAETDEIKILLEESRAQQK-----------------ETLKSLLEQETENLRTEISKLNQKIQDNNENyqvgLAELR 1126
Cdd:PRK03918   357 LEERHELYEEAKAKKEELERLKKrltgltpeklekeleelEKAKEEIEEEISKITARIGELKKEIKELKKA----IEELK 432
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1127 TlMTIEKDQCISELISRHEEE-SNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKL--DSELSALeRQKDEKITQQEE 1203
Cdd:PRK03918   433 K-AKGKCPVCGRELTEEHRKElLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLkkESELIKL-KELAEQLKELEE 510
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1204 KYEAIiqNLEKDRQKlvssqEQDREQLIQKLNCEKDEaIQTALKEFKLEREVVEK--ELLEKVKHLENQIAKSPAIDSTR 1281
Cdd:PRK03918   511 KLKKY--NLEELEKK-----AEEYEKLKEKLIKLKGE-IKSLKKELEKLEELKKKlaELEKKLDELEEELAELLKELEEL 582
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1282 GDSSslVAELQEKLQEEKAKFLEQLE----EQEKRKNEEMQNVRTSLIAEQQTNFNTVLTR-EKMRKEniINDLsdKLKS 1356
Cdd:PRK03918   583 GFES--VEELEERLKELEPFYNEYLElkdaEKELEREEKELKKLEEELDKAFEELAETEKRlEELRKE--LEEL--EKKY 656
                          570       580
                   ....*....|....*....|.
gi 1034662293 1357 TMQQQERDKDLIESLSEDRAR 1377
Cdd:PRK03918   657 SEEEYEELREEYLELSRELAG 677
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
949-1234 1.31e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 73.05  E-value: 1.31e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  949 KELKQSREIVLEDLKKLHVEN-DEKLQLLRAELQSLEQsHLKELEDTLQVR--HIQEFEKVMTDHRVSLEELKKENQQII 1025
Cdd:COG1196    216 RELKEELKELEAELLLLKLRElEAELEELEAELEELEA-ELEELEAELAELeaELEELRLELEELELELEEAQAEEYELL 294
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1026 NQIQESHAEIIQEKEkQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKEtLKSLLEQETENLRTEIS 1105
Cdd:COG1196    295 AELARLEQDIARLEE-RRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEE-AEAELAEAEEALLEAEA 372
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1106 KLNQKIQDNNENYQVGLAELRTLMTIEKDqcISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDS 1185
Cdd:COG1196    373 ELAEAEEELEELAEELLEALRAAAELAAQ--LEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEE 450
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 1034662293 1186 ELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKL 1234
Cdd:COG1196    451 EAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEA 499
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
862-1374 3.55e-12

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 71.31  E-value: 3.55e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  862 KHQKELLSLKNEYEGKLDGLIKETEEN---ENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEME 938
Cdd:pfam05557   24 EHKRARIELEKKASALKRQLDRESDRNqelQKRIRLLEKREAEAEEALREQAELNRLKKKYLEALNKKLNEKESQLADAR 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  939 NIMHSQNCEIKELKQSREIvledlkklhveNDEKLQLLRAELQSLEQSHlkeledTLQVRHIQEFEKVMTDHRVSLEELK 1018
Cdd:pfam05557  104 EVISCLKNELSELRRQIQR-----------AELELQSTNSELEELQERL------DLLKAKASEAEQLRQNLEKQQSSLA 166
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1019 KENQQII-----NQIQESHAEIIqekeKQLQELKLKVSDLSDTRCKLEVELAlKEAETDEIKILLEEsraqQKETLKSLL 1093
Cdd:pfam05557  167 EAEQRIKelefeIQSQEQDSEIV----KNSKSELARIPELEKELERLREHNK-HLNENIENKLLLKE----EVEDLKRKL 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1094 EQETE------NLRTEISKLNQKIQDNNENYQVGLAELRTLMTiekdqcISELISRHEEESNILKAElnkVTSLHNQAFE 1167
Cdd:pfam05557  238 EREEKyreeaaTLELEKEKLEQELQSWVKLAQDTGLNLRSPED------LSRRIEQLQQREIVLKEE---NSSLTSSARQ 308
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1168 IEKNLKEQIIEL---QSKLDSELSALERQKDEK---------ITQQEEKYEAIIQNLEKDRQKLVSSQEQDR-----EQL 1230
Cdd:pfam05557  309 LEKARRELEQELaqyLKKIEDLNKKLKRHKALVrrlqrrvllLTKERDGYRAILESYDKELTMSNYSPQLLErieeaEDM 388
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1231 IQKLNCeKDEAIQTALKefKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAkfleQLEEQE 1310
Cdd:pfam05557  389 TQKMQA-HNEEMEAQLS--VAEEELGGYKQQAQTLERELQALRQQESLADPSYSKEEVDSLRRKLETLEL----ERQRLR 461
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034662293 1311 KRKNE-EMQNVRTSLiaeqQTNFNTVLTREKMRKENIINDLSDKLKSTMQQ----QERDKDLIESLSED 1374
Cdd:pfam05557  462 EQKNElEMELERRCL----QGDYDPKKTKVLHLSMNPAAEAYQQRKNQLEKlqaeIERLKRLLKKLEDD 526
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
888-1371 4.25e-12

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 71.20  E-value: 4.25e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  888 NENKIKKLKGELVCLEEVLQNKDNEFALVkhekeaviclqnekDQKLLEMENIMHSQNCEIKELKQSreivLEDLKKLHV 967
Cdd:TIGR04523   31 QDTEEKQLEKKLKTIKNELKNKEKELKNL--------------DKNLNKDEEKINNSNNKIKILEQQ----IKDLNDKLK 92
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  968 ENDEKLQLLRAELQSLEqshlKELEDTLQVRHIQEFEKvmtdhrVSLEELKKENQQIINQIQEShaeiIQEKEKQLQELK 1047
Cdd:TIGR04523   93 KNKDKINKLNSDLSKIN----SEIKNDKEQKNKLEVEL------NKLEKQKKENKKNIDKFLTE----IKKKEKELEKLN 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1048 LKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQ--QKETLKSLLE---QETENLRTEISKLNQK---IQDNNENYQ 1119
Cdd:TIGR04523  159 NKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKllKLELLLSNLKkkiQKNKSLESQISELKKQnnqLKDNIEKKQ 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1120 VGLAELRTLMTIEKDQcISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEqiielqskLDSELSALERQKDEKIT 1199
Cdd:TIGR04523  239 QEINEKTTEISNTQTQ-LNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQ--------LKSEISDLNNQKEQDWN 309
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1200 QqeeKYEAIIQNLEKDRQKLvSSQEQDREQLIQKLNcEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQI----AKSP 1275
Cdd:TIGR04523  310 K---ELKSELKNQEKKLEEI-QNQISQNNKIISQLN-EQISQLKKELTNSESENSEKQRELEEKQNEIEKLKkenqSYKQ 384
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1276 AIDSTRGDSSSLVAEL--QEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNtvLTREKMRKENIINDLSDK 1353
Cdd:TIGR04523  385 EIKNLESQINDLESKIqnQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKD--LTNQDSVKELIIKNLDNT 462
                          490
                   ....*....|....*...
gi 1034662293 1354 LKSTMQQQERDKDLIESL 1371
Cdd:TIGR04523  463 RESLETQLKVLSRSINKI 480
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
830-1296 6.48e-12

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 70.87  E-value: 6.48e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  830 QCDFSNSLKCTAVEIRNIIEKvkcsleitlkekhqkellslkneyegkldglIKETEENENKIKKLKGElvcLEEVLQNK 909
Cdd:TIGR02169  141 QGDVTDFISMSPVERRKIIDE-------------------------------IAGVAEFDRKKEKALEE---LEEVEENI 186
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  910 DnefalvkhEKEAVIclqnekdqkllemenimhsqnceikelkqsrEIVLEDLKKLHVENDEKL--QLLRAELQSLEQS- 986
Cdd:TIGR02169  187 E--------RLDLII-------------------------------DEKRQQLERLRREREKAEryQALLKEKREYEGYe 227
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  987 HLKELEDTlqVRHIQEFEKvmtdhrvSLEELKKENQQIINQIQESHAEiIQEKEKQLQELKLKVSDLSDTRC-------- 1058
Cdd:TIGR02169  228 LLKEKEAL--ERQKEAIER-------QLASLEEELEKLTEEISELEKR-LEEIEQLLEELNKKIKDLGEEEQlrvkekig 297
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1059 KLEVELALKEAETDEIKILLEESRAQQKEtlkslLEQETENLRTEISKLNQKIQDNNenyqvglaelrtlmtIEKDQCIS 1138
Cdd:TIGR02169  298 ELEAEIASLERSIAEKERELEDAEERLAK-----LEAEIDKLLAEIEELEREIEEER---------------KRRDKLTE 357
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1139 ELISRhEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDS------ELSALERQKDEKITQQEEKYEAIIQNL 1212
Cdd:TIGR02169  358 EYAEL-KEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINElkreldRLQEELQRLSEELADLNAAIAGIEAKI 436
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1213 E------KDRQKLVSSQEQDREQLIQKLNCEKDEaiqtaLKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSS 1286
Cdd:TIGR02169  437 NeleeekEDKALEIKKQEWKLEQLAADLSKYEQE-----LYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRA 511
                          490
                   ....*....|
gi 1034662293 1287 LVAELQEKLQ 1296
Cdd:TIGR02169  512 VEEVLKASIQ 521
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
883-1219 1.73e-11

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 69.32  E-value: 1.73e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  883 KETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEaviclqnEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDL 962
Cdd:TIGR02168  677 REIEELEEKIEELEEKIAELEKALAELRKELEELEEELE-------QLRKELEELSRQISALRKDLARLEAEVEQLEERI 749
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  963 KKLHVENDEKLQLLRAELQSLEQSHLKELEdtlqvrhiqefekvmtdhrvsLEELKKENQQIINQIQESHA---EIIQEK 1039
Cdd:TIGR02168  750 AQLSKELTELEAEIEELEERLEEAEEELAE---------------------AEAEIEELEAQIEQLKEELKalrEALDEL 808
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1040 EKQLQELKLKVSDLSDTRCKLEVELALKEAETDEikilLEESRAQQKETLKSlLEQETENLRTEISKLNQKIQDNNENY- 1118
Cdd:TIGR02168  809 RAELTLLNEEAANLRERLESLERRIAATERRLED----LEEQIEELSEDIES-LAAEIEELEELIEELESELEALLNERa 883
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1119 --QVGLAELRTLMTIEKDQciselISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALER---Q 1193
Cdd:TIGR02168  884 slEEALALLRSELEELSEE-----LRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEeaeA 958
                          330       340
                   ....*....|....*....|....*.
gi 1034662293 1194 KDEKITQQEEKYEAIIQNLEKDRQKL 1219
Cdd:TIGR02168  959 LENKIEDDEEEARRRLKRLENKIKEL 984
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1019-1316 2.04e-11

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 69.32  E-value: 2.04e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1019 KENQQIINQIQEshaeiIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSL--LEQE 1096
Cdd:TIGR02168  667 KTNSSILERRRE-----IEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLarLEAE 741
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1097 TENLRTEISKLNQKIQDNNENYQVGLAELrtlmtiekdQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQI 1176
Cdd:TIGR02168  742 VEQLEERIAQLSKELTELEAEIEELEERL---------EEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAEL 812
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1177 IELQSKLD---SELSALERQKDEKITQQEEKYEAIIQNLEkDRQKLVSSQEQDREQLiqklncekdEAIQTALKEFKLER 1253
Cdd:TIGR02168  813 TLLNEEAAnlrERLESLERRIAATERRLEDLEEQIEELSE-DIESLAAEIEELEELI---------EELESELEALLNER 882
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034662293 1254 EVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKL---QEEKAKFLEQLEEQEKRKNEE 1316
Cdd:TIGR02168  883 ASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLaqlELRLEGLEVRIDNLQERLSEE 948
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
843-1321 2.13e-11

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 68.94  E-value: 2.13e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  843 EIRNIIEKVKcsLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKG------ELVCLEEVLQNKDNEFALV 916
Cdd:PRK03918   235 ELKEEIEELE--KELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKElkekaeEYIKLSEFYEEYLDELREI 312
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  917 KHEKEAVICLQNEKDQKLLEMENiMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQL------LRAELQSLEQSHLKE 990
Cdd:PRK03918   313 EKRLSRLEEEINGIEERIKELEE-KEERLEELKKKLKELEKRLEELEERHELYEEAKAKkeelerLKKRLTGLTPEKLEK 391
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  991 LEDTLQVR--HIQEFEKVMTDHRVSLEELKKENQQIINQIQESH-------AEIIQEKEKQL-QELKLKVSDLSDTRCKL 1060
Cdd:PRK03918   392 ELEELEKAkeEIEEEISKITARIGELKKEIKELKKAIEELKKAKgkcpvcgRELTEEHRKELlEEYTAELKRIEKELKEI 471
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1061 EVELALKEAETDEIKILLEESRAQQKetLKSLLEQeTENLRTEISKLN-QKIQDNNENYQVGLAELRTL----MTIEKDq 1135
Cdd:PRK03918   472 EEKERKLRKELRELEKVLKKESELIK--LKELAEQ-LKELEEKLKKYNlEELEKKAEEYEKLKEKLIKLkgeiKSLKKE- 547
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1136 ciselISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEaiIQNLEKD 1215
Cdd:PRK03918   548 -----LEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYNEYLELKDAEKE--LEREEKE 620
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1216 RQKLVSSQEQDREQLIQKLNC--EKDEAIQTALKEFKLER-EVVEKELLEKVKHLENQIAKSPAIDSTRGDssslVAELQ 1292
Cdd:PRK03918   621 LKKLEEELDKAFEELAETEKRleELRKELEELEKKYSEEEyEELREEYLELSRELAGLRAELEELEKRREE----IKKTL 696
                          490       500       510
                   ....*....|....*....|....*....|.
gi 1034662293 1293 EKLQEEKAKFLEQLEEQEK--RKNEEMQNVR 1321
Cdd:PRK03918   697 EKLKEELEEREKAKKELEKleKALERVEELR 727
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
855-1365 6.38e-11

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 67.37  E-value: 6.38e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  855 LEITLKEKHQKELLSLKNEYEGKL---DGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAvicLQNEKD 931
Cdd:PRK02224   192 LKAQIEEKEEKDLHERLNGLESELaelDEEIERYEEQREQARETRDEADEVLEEHEERREELETLEAEIED---LRETIA 268
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  932 QKLLEMENIMHsqncEIKELKQSREIVLEDLKKLhvendeklqLLRAELQSLEQSHLKELEDTLQVRhIQEFEKVMTDHR 1011
Cdd:PRK02224   269 ETEREREELAE----EVRDLRERLEELEEERDDL---------LAEAGLDDADAEAVEARREELEDR-DEELRDRLEECR 334
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1012 VSLEELKKEnqqiinqiQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQ------- 1084
Cdd:PRK02224   335 VAAQAHNEE--------AESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERfgdapvd 406
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1085 --QKETLKSLLEQETENLRTEISKLNQKIQDNNENyqvgLAELRTLM-------------------TIEKDQcisELISR 1143
Cdd:PRK02224   407 lgNAEDFLEELREERDELREREAELEATLRTARER----VEEAEALLeagkcpecgqpvegsphveTIEEDR---ERVEE 479
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1144 HEEESNILKAELNKVTSLHNQAfeieKNLKEQIIELQsKLDSELSALERQKDEKITQQEEKYEAiIQNLEKDRQKLVSSQ 1223
Cdd:PRK02224   480 LEAELEDLEEEVEEVEERLERA----EDLVEAEDRIE-RLEERREDLEELIAERRETIEEKRER-AEELRERAAELEAEA 553
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1224 EQDREQlIQKLNCEKDEAIQTaLKEFKLEREVVEKELlekvkhleNQIAKSPAIDSTRGDSSSLVAELQEKLQEekakfL 1303
Cdd:PRK02224   554 EEKREA-AAEAEEEAEEAREE-VAELNSKLAELKERI--------ESLERIRTLLAAIADAEDEIERLREKREA-----L 618
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034662293 1304 EQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTmqQQERDK 1365
Cdd:PRK02224   619 AELNDERRERLAEKRERKRELEAEFDEARIEEAREDKERAEEYLEQVEEKLDEL--REERDD 678
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
835-1220 1.13e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 66.63  E-value: 1.13e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  835 NSLKCTAVEIRNIIEKVK--------CSLEITlkEKHQKELLslkNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVL 906
Cdd:PRK03918   415 GELKKEIKELKKAIEELKkakgkcpvCGRELT--EEHRKELL---EEYTAELKRIEKELKEIEEKERKLRKELRELEKVL 489
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  907 qnkdnefalvkhekeaviclqnEKDQKLLEMENIMHsqncEIKELKQS-REIVLEDLKKlhveNDEKLQLLRAELQSLEq 985
Cdd:PRK03918   490 ----------------------KKESELIKLKELAE----QLKELEEKlKKYNLEELEK----KAEEYEKLKEKLIKLK- 538
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  986 SHLKELEDTLQvrHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELK--------LKVS-----D 1052
Cdd:PRK03918   539 GEIKSLKKELE--KLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEpfyneyleLKDAekeleR 616
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1053 LSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQvGLAELR--TLMT 1130
Cdd:PRK03918   617 EEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAELE-ELEKRReeIKKT 695
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1131 IEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSalerqkdEKITqqEEKYEAIIQ 1210
Cdd:PRK03918   696 LEKLKEELEEREKAKKELEKLEKALERVEELREKVKKYKALLKERALSKVGEIASEIF-------EELT--EGKYSGVRV 766
                          410
                   ....*....|
gi 1034662293 1211 NLEKDRQKLV 1220
Cdd:PRK03918   767 KAEENKVKLF 776
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1014-1373 1.40e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 66.62  E-value: 1.40e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1014 LEELKKENQQIinQIQESHAEIIQEKEKQLQELKLKVSDLSDTRckLEVELALKEAETDEIKILLEESRAQQKEtlkslL 1093
Cdd:TIGR02168  195 LNELERQLKSL--ERQAEKAERYKELKAELRELELALLVLRLEE--LREELEELQEELKEAEEELEELTAELQE-----L 265
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1094 EQETENLRTEISKLNQKIQDNNENYQVglaelrtlmtiekdqcISELISRHEEESNILKAELNkvtSLHNQAFEIEknlk 1173
Cdd:TIGR02168  266 EEKLEELRLEVSELEEEIEELQKELYA----------------LANEISRLEQQKQILRERLA---NLERQLEELE---- 322
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1174 EQIIELQSKLDsELSALERQKDEKITQQEEKYEAI---IQNLEKDRQKLVSSQEQDREQL-------IQKLNCEKDEAIQ 1243
Cdd:TIGR02168  323 AQLEELESKLD-ELAEELAELEEKLEELKEELESLeaeLEELEAELEELESRLEELEEQLetlrskvAQLELQIASLNNE 401
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1244 TALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELqEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTS 1323
Cdd:TIGR02168  402 IERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEEL-EELQEELERLEEALEELREELEEAEQALDAA 480
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1324 LIAEQQTNFNTVLTREKMRKeniINDLSDKLKSTMQQQERDKDLIESLSE 1373
Cdd:TIGR02168  481 ERELAQLQARLDSLERLQEN---LEGFSEGVKALLKNQSGLSGILGVLSE 527
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
864-1241 3.95e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 65.09  E-value: 3.95e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  864 QKELLSLKNEyegkLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENimhs 943
Cdd:TIGR02169  680 RERLEGLKRE----LSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQ---- 751
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  944 qncEIKELKQSreivLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQvRHIQEFEKVMTDHRVSLEELKKEnqq 1023
Cdd:TIGR02169  752 ---EIENVKSE----LKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQ-AELSKLEEEVSRIEARLREIEQK--- 820
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1024 iinqIQESHAEIIQEkEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSL--LEQETENLR 1101
Cdd:TIGR02169  821 ----LNRLTLEKEYL-EKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLgdLKKERDELE 895
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1102 TEISKLNQKIQDNNENYQvgLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLhnqafeieknlkEQIIELQS 1181
Cdd:TIGR02169  896 AQLRELERKIEELEAQIE--KKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSL------------EDVQAELQ 961
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1182 KLDSELSALERQKDEKItQQEEKYEAIIQNLEKDRQKLVSSQEQDREqLIQKLNCEKDEA 1241
Cdd:TIGR02169  962 RVEEEIRALEPVNMLAI-QEYEEVLKRLDELKEKRAKLEEERKAILE-RIEEYEKKKREV 1019
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1016-1286 7.93e-10

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 62.86  E-value: 7.93e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1016 ELKKENQQIINQIQEShaeiIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAEtdeikilLEESRAQQKEtlkslLEQ 1095
Cdd:COG4942     20 DAAAEAEAELEQLQQE----IAELEKELAALKKEEKALLKQLAALERRIAALARR-------IRALEQELAA-----LEA 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1096 ETENLRTEISKLNQKIQDNNENYQvglAELRTLMTIEKDQCISELISRHEEESNILKAELNKvtslhnqafEIEKNLKEQ 1175
Cdd:COG4942     84 ELAELEKEIAELRAELEAQKEELA---ELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLK---------YLAPARREQ 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1176 IIELQSKLDselsALERQKDEKITQQEEKyEAIIQNLEKDRQKLvSSQEQDREQLIQKLNCEKdEAIQTALKEFKLErev 1255
Cdd:COG4942    152 AEELRADLA----ELAALRAELEAERAEL-EALLAELEEERAAL-EALKAERQKLLARLEKEL-AELAAELAELQQE--- 221
                          250       260       270
                   ....*....|....*....|....*....|.
gi 1034662293 1256 vEKELLEKVKHLENQIAKSPAIDSTRGDSSS 1286
Cdd:COG4942    222 -AEELEALIARLEAEAAAAAERTPAAGFAAL 251
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
846-1353 1.03e-09

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 63.92  E-value: 1.03e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  846 NIIEKVKCSLEITLKEKHQkellSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKD-----NEFALVKHEK 920
Cdd:TIGR01612  533 NIKAKLYKEIEAGLKESYE----LAKNWKKLIHEIKKELEEENEDSIHLEKEIKDLFDKYLEIDDeiiyiNKLKLELKEK 608
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  921 EAVICLQNEKDQKLLEMENIMHSQNCEIKEL-KQSREIVLEdlkklHVENDEKL-QLLRAELQSLEQSHLKELEDTLQvR 998
Cdd:TIGR01612  609 IKNISDKNEYIKKAIDLKKIIENNNAYIDELaKISPYQVPE-----HLKNKDKIySTIKSELSKIYEDDIDALYNELS-S 682
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  999 HIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIqekEKQLQELKLKVSDLSDTrcKLEVELALKEAETDEIKILL 1078
Cdd:TIGR01612  683 IVKENAIDNTEDKAKLDDLKSKIDKEYDKIQNMETATV---ELHLSNIENKKNELLDI--IVEIKKHIHGEINKDLNKIL 757
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1079 EESRAQQKETLKSLLEQETEN-----LRTEISKL-----------NQKIQDNNENYQVGLAELRTLmTIEKDQcISELIS 1142
Cdd:TIGR01612  758 EDFKNKEKELSNKINDYAKEKdelnkYKSKISEIknhyndqinidNIKDEDAKQNYDKSKEYIKTI-SIKEDE-IFKIIN 835
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1143 RHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSalerqkDEKITQQEEKYeaiiqnleKDRQKLVSS 1222
Cdd:TIGR01612  836 EMKFMKDDFLNKVDKFINFENNCKEKIDSEHEQFAELTNKIKAEIS------DDKLNDYEKKF--------NDSKSLINE 901
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1223 QEQDREQLIQKLNCEKD--------EAIQTALKEFKLEREVVEKELLEKVKHLENqiakSPAIDSTRGDssSLVAELQEK 1294
Cdd:TIGR01612  902 INKSIEEEYQNINTLKKvdeyikicENTKESIEKFHNKQNILKEILNKNIDTIKE----SNLIEKSYKD--KFDNTLIDK 975
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1295 LQEEKAKFLE-QLEEQEKRKNEEMQNVrTSLIAEQQTNFNTVLTREKMRKENIINDLSDK 1353
Cdd:TIGR01612  976 INELDKAFKDaSLNDYEAKNNELIKYF-NDLKANLGKNKENMLYHQFDEKEKATNDIEQK 1034
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
798-1476 1.66e-09

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 63.14  E-value: 1.66e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  798 LERCRVVAQDSHFSIQTIKEDLCHFRTFVQKeqcdfsnslkctAVEIRNiiekvkcslEITLKEKHQKELLSLKNEYEGK 877
Cdd:TIGR00606  188 LETLRQVRQTQGQKVQEHQMELKYLKQYKEK------------ACEIRD---------QITSKEAQLESSREIVKSYENE 246
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  878 LDGL---IKETEENENKIKKLKGELVCL------------------EEVLQNKDNEFALVKHEKEAVIclqNEKDQKLLE 936
Cdd:TIGR00606  247 LDPLknrLKEIEHNLSKIMKLDNEIKALksrkkqmekdnselelkmEKVFQGTDEQLNDLYHNHQRTV---REKERELVD 323
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  937 MENIMHSQNCEIKELKQSREIVLEDLKKLHVEND-----------EKLQL-LRAELQSLEQSHLKELE----DTLQVRHI 1000
Cdd:TIGR00606  324 CQRELEKLNKERRLLNQEKTELLVEQGRLQLQADrhqehirardsLIQSLaTRLELDGFERGPFSERQiknfHTLVIERQ 403
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1001 QEFEKVMTDHRVSLEELKKENQQIINQIQE---SHAEIIQEK----EKQLQELKLKVSDLSDTRCK----LEVELALKEA 1069
Cdd:TIGR00606  404 EDEAKTAAQLCADLQSKERLKQEQADEIRDekkGLGRTIELKkeilEKKQEELKFVIKELQQLEGSsdriLELDQELRKA 483
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1070 ETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESN 1149
Cdd:TIGR00606  484 ERELSKAEKNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELT 563
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1150 ILKAELNKVTSLhNQAFEIEKNLKEQIIELQSKLDSELSALE------RQKDEKITQQEEKYEAII------QNLEKDRQ 1217
Cdd:TIGR00606  564 SLLGYFPNKKQL-EDWLHSKSKEINQTRDRLAKLNKELASLEqnknhiNNELESKEEQLSSYEDKLfdvcgsQDEESDLE 642
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1218 KLVSSQEQDREQL-------------IQKLNCEKDEAIQTALKEFKlerevVEKELLEKVKHLENQIAKSP-AIDST--- 1280
Cdd:TIGR00606  643 RLKEEIEKSSKQRamlagatavysqfITQLTDENQSCCPVCQRVFQ-----TEAELQEFISDLQSKLRLAPdKLKSTese 717
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1281 ------RGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSlIAEQQTNFNTVLTREKMRKE-----NIIND 1349
Cdd:TIGR00606  718 lkkkekRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKND-IEEQETLLGTIMPEEESAKVcltdvTIMER 796
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1350 LSDKLKSTMQQQER------DKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACApELPGESDR 1423
Cdd:TIGR00606  797 FQMELKDVERKIAQqaaklqGSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTN-ELKSEKLQ 875
                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034662293 1424 SAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRL 1476
Cdd:TIGR00606  876 IGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEEL 928
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
854-1242 1.92e-09

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 62.35  E-value: 1.92e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  854 SLEITLKEKhQKELLSLKNEYEGKLD---GLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEK 930
Cdd:TIGR04523  360 EKQRELEEK-QNEIEKLKKENQSYKQeikNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKN 438
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  931 DQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVEndeklqlLRAELQSLEQSHlKELEDtlQVRHIQEFEKVMTDH 1010
Cdd:TIGR04523  439 NSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRS-------INKIKQNLEQKQ-KELKS--KEKELKKLNEEKKEL 508
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1011 RVSLEELKKENQQIINQIQESHAEiIQEKEKQLQELKLKVSDLSD--TRCKLEVELALKEAETDEIKILLEESRAQQKET 1088
Cdd:TIGR04523  509 EEKVKDLTKKISSLKEKIEKLESE-KKEKESKISDLEDELNKDDFelKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEK 587
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1089 LKSL--LEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDqcISELISRHEEESNILKAELNKVTSLHNQAF 1166
Cdd:TIGR04523  588 QELIdqKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKN--IKSKKNKLKQEVKQIKETIKEIRNKWPEII 665
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1167 EIEKNLKE---QIIELQSKLDSELSA------LERQKDEKITQQEEKYEAIIQNLEKdrqklVSSQEQDREQLIQKLNCE 1237
Cdd:TIGR04523  666 KKIKESKTkidDIIELMKDWLKELSLhykkyiTRMIRIKDLPKLEEKYKEIEKELKK-----LDEFSKELENIIKNFNKK 740

                   ....*
gi 1034662293 1238 KDEAI 1242
Cdd:TIGR04523  741 FDDAF 745
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
877-1219 2.24e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 62.38  E-value: 2.24e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  877 KLDGLIKETEENenkIKKLKGELVCLEEVLQNKDNEFALvkhEKEAVICLQNEKDQKLLEMENIMHSQNCEIKEL---KQ 953
Cdd:TIGR02168  190 RLEDILNELERQ---LKSLERQAEKAERYKELKAELREL---ELALLVLRLEELREELEELQEELKEAEEELEELtaeLQ 263
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  954 SREIVLEDLKKLHVENDEKLQLLRAELQSLeQSHLKELEDTLQVrhiqefekvmtdHRVSLEELKKENQQIinqiqeshA 1033
Cdd:TIGR02168  264 ELEEKLEELRLEVSELEEEIEELQKELYAL-ANEISRLEQQKQI------------LRERLANLERQLEEL--------E 322
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1034 EIIQEKEKQLQELKLKVSDLsdtrcklEVELALKEAETDEIKILLEESRAQQK--ETLKSLLEQETENLRTEISKLNQKI 1111
Cdd:TIGR02168  323 AQLEELESKLDELAEELAEL-------EEKLEELKEELESLEAELEELEAELEelESRLEELEEQLETLRSKVAQLELQI 395
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1112 QDNNenyqvglAELRTLmtiekDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIElqsKLDSELSALE 1191
Cdd:TIGR02168  396 ASLN-------NEIERL-----EARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELE---ELQEELERLE 460
                          330       340
                   ....*....|....*....|....*...
gi 1034662293 1192 RQKdEKITQQEEKYEAIIQNLEKDRQKL 1219
Cdd:TIGR02168  461 EAL-EELREELEEAEQALDAAERELAQL 487
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1036-1245 2.87e-09

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 61.00  E-value: 2.87e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1036 IQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKEtlkslLEQETENLRTEISKLNQKIQDNN 1115
Cdd:COG3883     18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDK-----LQAEIAEAEAEIEERREELGERA 92
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1116 ENYQVGLAELRTLMTIEKDQCISELISRheeesniLKAeLNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKD 1195
Cdd:COG3883     93 RALYRSGGSVSYLDVLLGSESFSDFLDR-------LSA-LSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKA 164
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034662293 1196 EKITQQEEkyeaiIQNLEKDRQKLV---SSQEQDREQLIQKLNCEKDEAIQTA 1245
Cdd:COG3883    165 ELEAAKAE-----LEAQQAEQEALLaqlSAEEAAAEAQLAELEAELAAAEAAA 212
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
856-1371 4.09e-09

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 61.28  E-value: 4.09e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  856 EITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVL-QNKDNEFALVKHEKEAVICLQNE-KDQK 933
Cdd:pfam05483  234 EINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLkELIEKKDHLTKELEDIKMSLQRSmSTQK 313
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  934 LLEMENIMHSQNceIKELKQSREIVLEDLKKLHVENDEKL-----------QLLRAELQSLE--QSHLKELEDTLQVR-- 998
Cdd:pfam05483  314 ALEEDLQIATKT--ICQLTEEKEAQMEELNKAKAAHSFVVtefeattcsleELLRTEQQRLEknEDQLKIITMELQKKss 391
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  999 HIQEFEKVMTDHRVSLEELKK---ENQQIINQIQ--ESHAEIIQEKEKQLQE-LKLKVSDLSDtrckLEVEL-ALKEAET 1071
Cdd:pfam05483  392 ELEEMTKFKNNKEVELEELKKilaEDEKLLDEKKqfEKIAEELKGKEQELIFlLQAREKEIHD----LEIQLtAIKTSEE 467
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1072 DEIKILLEESRAQQKETLKSL-LEQETENLRTEISKLNQKIQDnnenyqvglaelrtlMTIEKDQCISELISRHEEESNI 1150
Cdd:pfam05483  468 HYLKEVEDLKTELEKEKLKNIeLTAHCDKLLLENKELTQEASD---------------MTLELKKHQEDIINCKKQEERM 532
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1151 LKAELN---KVTSLHNQAFEIEKNLKEQIIELQSKLD--SELSALERQKDEKITQQEEKYEAIIQNLEK---DRQKLVSS 1222
Cdd:pfam05483  533 LKQIENleeKEMNLRDELESVREEFIQKGDEVKCKLDksEENARSIEYEVLKKEKQMKILENKCNNLKKqieNKNKNIEE 612
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1223 QEQDREQLIQKLNCEKDEAIQTALKEFKLEREVV-------------EKELLEKVKHLENQIAKSPAIDSTRGDSSSLVA 1289
Cdd:pfam05483  613 LHQENKALKKKGSAENKQLNAYEIKVNKLELELAsakqkfeeiidnyQKEIEDKKISEEKLLEEVEKAKAIADEAVKLQK 692
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1290 ELQEKLQEEKAKFLEQLEEQEKRKNEemqnvrtsLIAEQQTNFNTVLTRE------KMRKENIINDLSDKLKSTMQQQER 1363
Cdd:pfam05483  693 EIDKRCQHKIAEMVALMEKHKHQYDK--------IIEERDSELGLYKNKEqeqssaKAALEIELSNIKAELLSLKKQLEI 764

                   ....*...
gi 1034662293 1364 DKDLIESL 1371
Cdd:pfam05483  765 EKEEKEKL 772
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
903-1377 4.16e-09

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 61.73  E-value: 4.16e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  903 EEVLQNKDNEFALVKHEKEAVICLQNE---KDQKLLEMENIMHSQNCEIKEL--------------KQSREIVLEDLKKL 965
Cdd:pfam01576    4 EEEMQAKEEELQKVKERQQKAESELKElekKHQQLCEEKNALQEQLQAETELcaeaeemrarlaarKQELEEILHELESR 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  966 HVENDEKLQLLRAELQSLEQsHLKELEDTLQ----VRHIQEFEKVMTDHRV-SLEE-----------LKKENQQIINQIQ 1029
Cdd:pfam01576   84 LEEEEERSQQLQNEKKKMQQ-HIQDLEEQLDeeeaARQKLQLEKVTTEAKIkKLEEdillledqnskLSKERKLLEERIS 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1030 E--SHAEIIQEKEKQLQELKLK----VSDLSD-------TRCKLEVELALKEAETDEIKILLEESRAQQKEtLKSLLEQE 1096
Cdd:pfam01576  163 EftSNLAEEEEKAKSLSKLKNKheamISDLEErlkkeekGRQELEKAKRKLEGESTDLQEQIAELQAQIAE-LRAQLAKK 241
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1097 TENLRTEISKLNQKIQDNNE------NYQVGLAELRTLMTIEKDQ-CISELISRH-EEESNILKAELNKVTSLHNQAFEI 1168
Cdd:pfam01576  242 EEELQAALARLEEETAQKNNalkkirELEAQISELQEDLESERAArNKAEKQRRDlGEELEALKTELEDTLDTTAAQQEL 321
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1169 EKNLKEQIIELQSKLDSELSALE------RQKD----EKITQQEEKYEAIIQNLEKDRQ-------------KLVSSQEQ 1225
Cdd:pfam01576  322 RSKREQEVTELKKALEEETRSHEaqlqemRQKHtqalEELTEQLEQAKRNKANLEKAKQalesenaelqaelRTLQQAKQ 401
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1226 DREQLIQKLNCEKDEaIQTALKEFKLEREvvekELLEKVKHLENQIAK-SPAIDSTRGDSSSL---VAELQEKLQEEKak 1301
Cdd:pfam01576  402 DSEHKRKKLEGQLQE-LQARLSESERQRA----ELAEKLSKLQSELESvSSLLNEAEGKNIKLskdVSSLESQLQDTQ-- 474
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034662293 1302 flEQLEEQEKRKNEEMQNVRTslIAEQQTNFNTVLTREKMRKENI---INDLSDKLKSTMQQQERDKDLIESLSEDRAR 1377
Cdd:pfam01576  475 --ELLQEETRQKLNLSTRLRQ--LEDERNSLQEQLEEEEEAKRNVerqLSTLQAQLSDMKKKLEEDAGTLEALEEGKKR 549
CCDC73 pfam15818
Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil ...
1012-1347 5.23e-09

Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil containing proteins. The function is not known. The alternative name is sarcoma antigen NY-SAR-79.


Pssm-ID: 464893 [Multi-domain]  Cd Length: 1048  Bit Score: 61.12  E-value: 5.23e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1012 VSLEELKKENQQIINQ---IQESHAEIIQEKEKQLQelkLKVSDLSDTRCKLEVELALKEAETDEIKilleesraqqkET 1088
Cdd:pfam15818   35 VETQELKWQKETLQNQketLAKQHKEAMAVFKKQLQ---MKMCALEEEKGKYQLATEIKEKEIEGLK-----------ET 100
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1089 LKSLlEQETENLRTEISKLNQKIQDN---NENYQVGLAELRTLMT-----------------------IEKDQCISELIS 1142
Cdd:pfam15818  101 LKAL-QVSKYSLQKKVSEMEQKLQLHllaKEDHHKQLNEIEKYYAtitgqfglvkenhgkleqnvqeaIQLNKRLSALNK 179
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1143 RHEEESNILKAELNKVTS---------LHNQAFE-IEKNLKEQII-ELQSKLDSELsALERQKDEKITQ-QEEKYEAIIQ 1210
Cdd:pfam15818  180 KQESEICSLKKELKKVTSdlikskvtcQYKMGEEnINLTIKEQKFqELQERLNMEL-ELNKKINEEITHiQEEKQDIIIS 258
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1211 NleKDRQKLVSSQEQDREQLIQKLNCEKdEAIQTALKEFKLEREVVeKELLEKVKHLENQIAK------------SPAID 1278
Cdd:pfam15818  259 F--QHMQQLLQQQTQANTEMEAELKALK-ENNQTLERDNELQREKV-KENEEKFLNLQNEHEKalgtwkkhveelNGEIN 334
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034662293 1279 STRGDSSSLvAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVrtsliaeqqTNFNTVLTREKMrkENII 1347
Cdd:pfam15818  335 EIKNELSSL-KETHIKLQEHYNKLCNQKKFEEDKKFQNVPEV---------NNENSEMSTEKS--ENLI 391
CCDC73 pfam15818
Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil ...
886-1315 5.55e-09

Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil containing proteins. The function is not known. The alternative name is sarcoma antigen NY-SAR-79.


Pssm-ID: 464893 [Multi-domain]  Cd Length: 1048  Bit Score: 61.12  E-value: 5.55e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  886 EENENKIKKLKGELVCLEEVLQNKDNefALVKHEKEAVICLQNEKDQKL--LEMENIMHSQNCEIKElkqsREIvlEDLK 963
Cdd:pfam15818   27 EEQIGKIIVETQELKWQKETLQNQKE--TLAKQHKEAMAVFKKQLQMKMcaLEEEKGKYQLATEIKE----KEI--EGLK 98
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  964 klhvendEKLQLLRAELQSLeQSHLKELEDTLQVRHIQEfekvmTDHRVSLEELKKENQQIINQ---IQESHAEIIQEKE 1040
Cdd:pfam15818   99 -------ETLKALQVSKYSL-QKKVSEMEQKLQLHLLAK-----EDHHKQLNEIEKYYATITGQfglVKENHGKLEQNVQ 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1041 KQLQeLKLKVSDLSDTR----CKLEVElaLKEAETDEIKILLEESRAQQKETLK-SLLEQETENLRTEIS---KLNQKIQ 1112
Cdd:pfam15818  166 EAIQ-LNKRLSALNKKQeseiCSLKKE--LKKVTSDLIKSKVTCQYKMGEENINlTIKEQKFQELQERLNmelELNKKIN 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1113 DNNENYQVGLAELrtlmtIEKDQCISELISRHEEESNILKAELnKVTSLHNQAFEieknlkeqiielqskLDSELsaler 1192
Cdd:pfam15818  243 EEITHIQEEKQDI-----IISFQHMQQLLQQQTQANTEMEAEL-KALKENNQTLE---------------RDNEL----- 296
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1193 qKDEKITQQEEKYeaiiQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLER---EVVEKELLEKVKHLEN 1269
Cdd:pfam15818  297 -QREKVKENEEKF----LNLQNEHEKALGTWKKHVEELNGEINEIKNELSSLKETHIKLQEhynKLCNQKKFEEDKKFQN 371
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1034662293 1270 -QIAKSPAIDSTRGDSSSLVAE----LQEKLQEEKAKFLEQLEEQEKRKNE 1315
Cdd:pfam15818  372 vPEVNNENSEMSTEKSENLIIQkynsEQEIREENTKSFCSDTEYRETEKKK 422
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
929-1478 6.71e-09

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 60.76  E-value: 6.71e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  929 EKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEdtlqvRHIQEFEKVMT 1008
Cdd:pfam02463  173 EALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNE-----ERIDLLQELLR 247
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1009 DHRVSLEELKKENQQIINQIQESHAEIIQE-KEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKE 1087
Cdd:pfam02463  248 DEQEEIESSKQEIEKEEEKLAQVLKENKEEeKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAE 327
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1088 tlKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSlhnqafe 1167
Cdd:pfam02463  328 --KELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELE------- 398
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1168 iEKNLKEQIIELQSKL-DSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTAL 1246
Cdd:pfam02463  399 -LKSEEEKEAQLLLELaRQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKET 477
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1247 KEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNE---EMQNVRTS 1323
Cdd:pfam02463  478 QLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAIStavIVEVSATA 557
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1324 LIAEQQTNFNTVLTREK--MRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSP 1401
Cdd:pfam02463  558 DEVEERQKLVRALTELPlgARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKL 637
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1402 YVATAPELYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLS---EEKQRIMLLERTLQLKEEENKRLNQ 1478
Cdd:pfam02463  638 KESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELakeEILRRQLEIKKKEQREKEELKKLKL 717
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
870-1377 6.95e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 60.55  E-value: 6.95e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  870 LKNEYEGKLDGLIKET----EENENKIKKLKGELvcleEVLQNKDNEFALVKHEKEaviclqnEKDQKLLEMENimhsqn 945
Cdd:COG4717     47 LLERLEKEADELFKPQgrkpELNLKELKELEEEL----KEAEEKEEEYAELQEELE-------ELEEELEELEA------ 109
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  946 cEIKELKQSREiVLEDLKKLHvENDEKLQLLRAELQSLEQsHLKELEDtlQVRHIQEFEKVMTDHRVSLEELKKENQQII 1025
Cdd:COG4717    110 -ELEELREELE-KLEKLLQLL-PLYQELEALEAELAELPE-RLEELEE--RLEELRELEEELEELEAELAELQEELEELL 183
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1026 NQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQK-ETLKSLLEQETenLRTEI 1104
Cdd:COG4717    184 EQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERlKEARLLLLIAA--ALLAL 261
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1105 SKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAElnkvtslhnqafEIEKNLKEQIIELQSKLD 1184
Cdd:COG4717    262 LGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALP------------ALEELEEEELEELLAALG 329
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1185 SELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLERevvekELLEKV 1264
Cdd:COG4717    330 LPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQ-----ELKEEL 404
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1265 KHLENQIAKSPaidstrGDSSSLVAELQEKLQEEKakfLEQLEEQEKRKNEEMQNvrtsliaeqqtnfntvLTREKMRKE 1344
Cdd:COG4717    405 EELEEQLEELL------GELEELLEALDEEELEEE---LEELEEELEELEEELEE----------------LREELAELE 459
                          490       500       510
                   ....*....|....*....|....*....|....*
gi 1034662293 1345 NIINDL--SDKLKSTMQQQERDKDLIESLSEDRAR 1377
Cdd:COG4717    460 AELEQLeeDGELAELLQELEELKAELRELAEEWAA 494
PRK11281 PRK11281
mechanosensitive channel MscK;
926-1297 7.19e-09

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 60.70  E-value: 7.19e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  926 LQNEKDQKLLEMENIMHSQNCE--------IKELKQSreivLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQV 997
Cdd:PRK11281    45 LDALNKQKLLEAEDKLVQQDLEqtlalldkIDRQKEE----TEQLKQQLAQAPAKLRQAQAELEALKDDNDEETRETLST 120
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  998 RHIQEFEKVMTDHRVSLEELKKE----NQQIIN---QIQESHAEI------IQEKEKQLQELKLKVSDLSDT-RCKLEVE 1063
Cdd:PRK11281   121 LSLRQLESRLAQTLDQLQNAQNDlaeyNSQLVSlqtQPERAQAALyansqrLQQIRNLLKGGKVGGKALRPSqRVLLQAE 200
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1064 LALKEAETDEIKILLEESraqqkETLKSLLEQETENLRTEISKLNQKIQD-----NNENYQVGLAELRTLMTIEKDQCIS 1138
Cdd:PRK11281   201 QALLNAQNDLQRKSLEGN-----TQLQDLLQKQRDYLTARIQRLEHQLQLlqeaiNSKRLTLSEKTVQEAQSQDEAARIQ 275
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1139 E--LISRhEEESN------ILKA--ELNKVT----SLHNQ---AFEIEKNLKEQIIELQ------------------SKL 1183
Cdd:PRK11281   276 AnpLVAQ-ELEINlqlsqrLLKAteKLNTLTqqnlRVKNWldrLTQSERNIKEQISVLKgslllsrilyqqqqalpsADL 354
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1184 DSELS---ALERQKDEKITQQEEKY---EAIIQNLEKDRQKLVSSQEqdREQLIQKLNcekdeaiqtalkefklEREvve 1257
Cdd:PRK11281   355 IEGLAdriADLRLEQFEINQQRDALfqpDAYIDKLEAGHKSEVTDEV--RDALLQLLD----------------ERR--- 413
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|.
gi 1034662293 1258 kELLEKV-KHLENQIAKSPAIDSTRGDSSSLVAELQEKLQE 1297
Cdd:PRK11281   414 -ELLDQLnKQLNNQLNLAINLQLNQQQLLSVSDSLQSTLTQ 453
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
863-1368 1.32e-08

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 59.77  E-value: 1.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  863 HQKELLSLKNEYEGKLDGLIKETEENENKIKKLK----GELVCLEEVLQNKD---NEFALVKHEKEAVICL-QNEKDQKL 934
Cdd:pfam07111  149 HQEQLSSLTQAHEEALSSLTSKAEGLEKSLNSLEtkraGEAKQLAEAQKEAEllrKQLSKTQEELEAQVTLvESLRKYVG 228
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  935 LEMENIMHSQNCEIKelkqsREIVLEDLKKLHVENDE---KLQLLRAELQSLeqSHLKELEDTLQVRHIQ-------EFE 1004
Cdd:pfam07111  229 EQVPPEVHSQTWELE-----RQELLDTMQHLQEDRADlqaTVELLQVRVQSL--THMLALQEEELTRKIQpsdslepEFP 301
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1005 K----VMTDHR-------VSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVE------LALK 1067
Cdd:pfam07111  302 KkcrsLLNRWRekvfalmVQLKAQDLEHRDSVKQLRGQVAELQEQVTSQSQEQAILQRALQDKAAEVEVErmsakgLQME 381
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1068 EAETDEIKILLEESRAQQKETLK---SLLEQETENLRTEISKLNQKIQdnnenyQVGLAELRTLMTIEKDQCISELISRh 1144
Cdd:pfam07111  382 LSRAQEARRRQQQQTASAEEQLKfvvNAMSSTQIWLETTMTRVEQAVA------RIPSLSNRLSYAVRKVHTIKGLMAR- 454
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1145 eeesNILKAELNKVTS-LHNQAFEIEKNLK---EQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLV 1220
Cdd:pfam07111  455 ----KVALAQLRQESCpPPPPAPPVDADLSlelEQLREERNRLDAELQLSAHLIQQEVGRAREQGEAERQQLSEVAQQLE 530
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1221 SSQEQDREQLIQkLNCEKDEAIQTalkefklerevvEKELLEKVKHLENQIAKSPAIDSTrgdssslvaELQEKLQEEKA 1300
Cdd:pfam07111  531 QELQRAQESLAS-VGQQLEVARQG------------QQESTEEAASLRQELTQQQEIYGQ---------ALQEKVAEVET 588
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034662293 1301 KFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTvlTREKMR-------KENIINDLSDKLKSTMQQQERDKDLI 1368
Cdd:pfam07111  589 RLREQLSDTKRRLNEARREQAKAVVSLRQIQHRA--TQEKERnqelrrlQDEARKEEGQRLARRVQELERDKNLM 661
PTZ00121 PTZ00121
MAEBL; Provisional
841-1374 2.43e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 59.38  E-value: 2.43e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  841 AVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELvclEEvlQNKDNEFALVKHEK 920
Cdd:PTZ00121  1280 ADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKA---EE--AKKAAEAAKAEAEA 1354
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  921 EAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKL-QLLRAELQSLEQSHLKELEDtlQVRH 999
Cdd:PTZ00121  1355 AADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKAdELKKAAAAKKKADEAKKKAE--EKKK 1432
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1000 IQEFEKVMTDHRVSlEELKKENQQiinQIQESHAEIIQEKEKQLQELKLKVSDlsdtrcKLEVELALKEAETDEIKILLE 1079
Cdd:PTZ00121  1433 ADEAKKKAEEAKKA-DEAKKKAEE---AKKAEEAKKKAEEAKKADEAKKKAEE------AKKADEAKKKAEEAKKKADEA 1502
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1080 ESRAQQKETLKSLLEQETENLRTEISKLNQKiqdnnenyqvglaelrtlmtiekdqciselisRHEEESNilKAELNKVT 1159
Cdd:PTZ00121  1503 KKAAEAKKKADEAKKAEEAKKADEAKKAEEA--------------------------------KKADEAK--KAEEKKKA 1548
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1160 SLHNQAFEIEKNLKEQIIElQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQ-EQDREQLIQKLNCEK 1238
Cdd:PTZ00121  1549 DELKKAEELKKAEEKKKAE-EAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEaKKAEEAKIKAEELKK 1627
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1239 DEAIQTALKEFKlEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQL--EEQEKRKNEE 1316
Cdd:PTZ00121  1628 AEEEKKKVEQLK-KKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALkkEAEEAKKAEE 1706
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034662293 1317 MQNVRtsliAEQqtnfntVLTREKMRKENIINDLsdKLKSTMQQQERDKDLIESLSED 1374
Cdd:PTZ00121  1707 LKKKE----AEE------KKKAEELKKAEEENKI--KAEEAKKEAEEDKKKAEEAKKD 1752
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
866-1356 2.69e-08

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 59.07  E-value: 2.69e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  866 ELLSLKNEYEGKLdgliketEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQN--EKDQKLLEMENIMHS 943
Cdd:PTZ00440   440 EIIEIKKKYDEKI-------NELKKSINQLKTLISIMKSFYDLIISEKDSMDSKEKKESSDSNyqEKVDELLQIINSIKE 512
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  944 QNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTL---QVRHIQEFEKVMTDHRVSLEELKKE 1020
Cdd:PTZ00440   513 KNNIVNNNFKNIEDYYITIEGLKNEIEGLIELIKYYLQSIETLIKDEKLKRSmknDIKNKIKYIEENVDHIKDIISLNDE 592
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1021 NQQIINQIQESHAEIIQEKEK---QLQELKLKVSDLSDTRCKLEvelaLKEAETDEIKILLEESRAQQKETLKSLLEQET 1097
Cdd:PTZ00440   593 IDNIIQQIEELINEALFNKEKfinEKNDLQEKVKYILNKFYKGD----LQELLDELSHFLDDHKYLYHEAKSKEDLQTLL 668
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1098 ENLRTEISKLNQKIQDNNENYQVGL-AELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEK------ 1170
Cdd:PTZ00440   669 NTSKNEYEKLEFMKSDNIDNIIKNLkKELQNLLSLKENIIKKQLNNIEQDISNSLNQYTIKYNDLKSSIEEYKEeeekle 748
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1171 NLKEQIIELQSKLDSELsaleRQKDEKITQQEEKYEAIIQNLE----------------KDRQKLVSSQEQDREQLIQKL 1234
Cdd:PTZ00440   749 VYKHQIINRKNEFILHL----YENDKDLPDGKNTYEEFLQYKDtilnkenkisndinilKENKKNNQDLLNSYNILIQKL 824
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1235 NC---EKDEAIQTALKEFKLEREVV-----EKELLEKVKHLENQIAK--------------SPAIDSTRGDSSSL----- 1287
Cdd:PTZ00440   825 EAhteKNDEELKQLLQKFPTEDENLnlkelEKEFNENNQIVDNIIKDienmnkniniiktlNIAINRSNSNKQLVehlln 904
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1288 -VAELQEKL--------------QEEKAKFLEQLEEQEKRKNEEMQNvrtSLIAEQQTNFNTVLTREKMRKENIINDLSD 1352
Cdd:PTZ00440   905 nKIDLKNKLeqhmkiintdniiqKNEKLNLLNNLNKEKEKIEKQLSD---TKINNLKMQIEKTLEYYDKSKENINGNDGT 981

                   ....
gi 1034662293 1353 KLKS 1356
Cdd:PTZ00440   982 HLEK 985
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
843-1373 2.83e-08

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 58.58  E-value: 2.83e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  843 EIRNIIEKVKCSLEITLKEKHQKeLLSLKNEY-------EGKLDGLIKETEENENKIKklkgELVCLEEVLQNKDNEFal 915
Cdd:pfam05483  201 ELRVQAENARLEMHFKLKEDHEK-IQHLEEEYkkeindkEKQVSLLLIQITEKENKMK----DLTFLLEESRDKANQL-- 273
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  916 vkhekEAVICLQNEKDQKLLEMEnimHSQNCEIKELKQSREIVLEDLKKLhvenDEKLQLLRAELQSLEQSHLKELEDTL 995
Cdd:pfam05483  274 -----EEKTKLQDENLKELIEKK---DHLTKELEDIKMSLQRSMSTQKAL----EEDLQIATKTICQLTEEKEAQMEELN 341
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  996 QVRHIQEFekVMTDHRV---SLEELKKENQQIINQIQESHAEIIQEKEKQLQELKlKVSDLSDTrcklevelalKEAETD 1072
Cdd:pfam05483  342 KAKAAHSF--VVTEFEAttcSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELE-EMTKFKNN----------KEVELE 408
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1073 EIKILLEESRAQQKEtlKSLLEQETENLRTEISKLNQKIQDNNEnyQVGLAELRTLMTIEKDQCISELISRHEEESNILK 1152
Cdd:pfam05483  409 ELKKILAEDEKLLDE--KKQFEKIAEELKGKEQELIFLLQAREK--EIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEK 484
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1153 AELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKdekitQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQ 1232
Cdd:pfam05483  485 LKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCK-----KQEERMLKQIENLEEKEMNLRDELESVREEFIQ 559
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1233 -----KLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIA-KSPAIDSTRGDSSSL-----VAELQEKLQEEKAK 1301
Cdd:pfam05483  560 kgdevKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIEnKNKNIEELHQENKALkkkgsAENKQLNAYEIKVN 639
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034662293 1302 FLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLtrEKMRKENIINDLSDKLkstmqQQERDKDLIESLSE 1373
Cdd:pfam05483  640 KLELELASAKQKFEEIIDNYQKEIEDKKISEEKLL--EEVEKAKAIADEAVKL-----QKEIDKRCQHKIAE 704
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
917-1276 3.08e-08

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 58.60  E-value: 3.08e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  917 KHEKEAVICLQNEKDQKLLEME---NIMHSQNCEIKELKQSREIVLEDlKKLHVENDEKLQLLRAELQSLEQSHLKELED 993
Cdd:pfam17380  292 KFEKMEQERLRQEKEEKAREVErrrKLEEAEKARQAEMDRQAAIYAEQ-ERMAMERERELERIRQEERKRELERIRQEEI 370
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  994 TLQVRHIQEFEkvmtdhRVSLEELKKeNQQIINQIQESHAEIIQEKEKQlQELKLKVSDLSDTRCKLEvelalkEAETDE 1073
Cdd:pfam17380  371 AMEISRMRELE------RLQMERQQK-NERVRQELEAARKVKILEEERQ-RKIQQQKVEMEQIRAEQE------EARQRE 436
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1074 IKILlEESRAQQKETLKslleQETENLRTEISKLNQKIQDNNenyqvglaelRTLMTIEKDQCISELIsrHEEESNILKA 1153
Cdd:pfam17380  437 VRRL-EEERAREMERVR----LEEQERQQQVERLRQQEEERK----------RKKLELEKEKRDRKRA--EEQRRKILEK 499
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1154 ELNKvtslhNQAFEIEKNLKEQIIELQSKldselsalERQKdeKITQQEEKYEAiiqnlEKDRQKLVSSQEQDREQliqk 1233
Cdd:pfam17380  500 ELEE-----RKQAMIEEERKRKLLEKEME--------ERQK--AIYEEERRREA-----EEERRKQQEMEERRRIQ---- 555
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 1034662293 1234 lncekdEAIQTALKE-FKLEREVVEKELLEKVKHLENQIAKSPA 1276
Cdd:pfam17380  556 ------EQMRKATEErSRLEAMEREREMMRQIVESEKARAEYEA 593
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
843-1395 3.51e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 58.54  E-value: 3.51e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  843 EIRNIIEKVKCSLEITLKEKHQKE----LLSLKNEYEGKLdgLIKETEENENKIKKLKGELVCLEEVLQNKD---NEFAL 915
Cdd:TIGR02169  188 RLDLIIDEKRQQLERLRREREKAEryqaLLKEKREYEGYE--LLKEKEALERQKEAIERQLASLEEELEKLTeeiSELEK 265
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  916 VKHEKEAVICLQNEKDQKLLEMENI-----MHSQNCEIKELKQS---REIVLEDLKKLHVENDEKLQLLRAELQSLE--- 984
Cdd:TIGR02169  266 RLEEIEQLLEELNKKIKDLGEEEQLrvkekIGELEAEIASLERSiaeKERELEDAEERLAKLEAEIDKLLAEIEELErei 345
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  985 ----------QSHLKELEDTLQVRhIQEFEKVMTDHRVSLEELKKEnQQIINQIQESHAEIIQEKEKQLQELKLKVSDLS 1054
Cdd:TIGR02169  346 eeerkrrdklTEEYAELKEELEDL-RAELEEVDKEFAETRDELKDY-REKLEKLKREINELKRELDRLQEELQRLSEELA 423
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1055 DTRCKLEV---ELALKEAETDEIKILLEESRAQQKETLKSL--LEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLM 1129
Cdd:TIGR02169  424 DLNAAIAGieaKINELEEEKEDKALEIKKQEWKLEQLAADLskYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASE 503
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1130 TIEKD-QCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSElSALERQKDEKITQQ------- 1201
Cdd:TIGR02169  504 ERVRGgRAVEEVLKASIQGVHGTVAQLGSVGERYATAIEVAAGNRLNNVVVEDDAVAK-EAIELLKRRKAGRAtflplnk 582
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1202 --------------------------EEKYEAIIQNLEKDrQKLVSSQEQDREQLIQ----KLN---CEKDEAI------ 1242
Cdd:TIGR02169  583 mrderrdlsilsedgvigfavdlvefDPKYEPAFKYVFGD-TLVVEDIEAARRLMGKyrmvTLEgelFEKSGAMtggsra 661
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1243 QTALKEFKLEREVVEKELLEKVKHLENQ----IAKSPAIDSTRGDSSSLVAELQEKLqEEKAKFLEQLEEQEKRKNEEMQ 1318
Cdd:TIGR02169  662 PRGGILFSRSEPAELQRLRERLEGLKRElsslQSELRRIENRLDELSQELSDASRKI-GEIEKEIEQLEQEEEKLKERLE 740
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034662293 1319 NVRTSLIAEQQTnfntvLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKL-EEEVSKLRSS 1395
Cdd:TIGR02169  741 ELEEDLSSLEQE-----IENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKlEEEVSRIEAR 813
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
854-1375 5.13e-08

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 57.91  E-value: 5.13e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  854 SLEITLKEKhQKELLSLKNEYEGKLDGLIK--ETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEaVICLQNEKD 931
Cdd:pfam10174  196 HLEVLLDQK-EKENIHLREELHRRNQLQPDpaKTKALQTVIEMKDTKISSLERNIRDLEDEVQMLKTNGL-LHTEDREEE 273
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  932 QKLLEMENiMHSQ--NCEIKELKQ-----SREIV-----LEDLKKLHVENDEKLQLLRAELQSLEQ--SHLKELEDTLQV 997
Cdd:pfam10174  274 IKQMEVYK-SHSKfmKNKIDQLKQelskkESELLalqtkLETLTNQNSDCKQHIEVLKESLTAKEQraAILQTEVDALRL 352
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  998 RhIQEFEKVMTDHRVSLEELKKE-----------------NQQIINQIQ---ESHAEIIQEKEKQLQELKLKVSDLSDTR 1057
Cdd:pfam10174  353 R-LEEKESFLNKKTKQLQDLTEEkstlageirdlkdmldvKERKINVLQkkiENLQEQLRDKDKQLAGLKERVKSLQTDS 431
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1058 CKLEVELA-LKEAETDEIKILleESRAQQKETLKSLLEQETENLRTEISKLNQKiqdnnenyqvgLAELRTLMTiEKDQC 1136
Cdd:pfam10174  432 SNTDTALTtLEEALSEKERII--ERLKEQREREDRERLEELESLKKENKDLKEK-----------VSALQPELT-EKESS 497
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1137 ISELisrheeesnilkaeLNKVTSLHNQAFEIEKNLKEQIIELQSKLDsELSALERQ--KDEKITQQEEKYEAI---IQN 1211
Cdd:pfam10174  498 LIDL--------------KEHASSLASSGLKKDSKLKSLEIAVEQKKE-ECSKLENQlkKAHNAEEAVRTNPEIndrIRL 562
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1212 LEKD--RQKLVSSQEQ-DREQLIQklncekdeaiqtALKEFKLEREVVEKELLEKVKHLENQIaKSPAIDstrgdssslV 1288
Cdd:pfam10174  563 LEQEvaRYKEESGKAQaEVERLLG------------ILREVENEKNDKDKKIAELESLTLRQM-KEQNKK---------V 620
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1289 AELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEqqtnfnTVLTREKMRKEniINDLSDKLKSTMQQ-QERDKDL 1367
Cdd:pfam10174  621 ANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQLQLEE------LMGALEKTRQE--LDATKARLSSTQQSlAEKDGHL 692

                   ....*...
gi 1034662293 1368 iESLSEDR 1375
Cdd:pfam10174  693 -TNLRAER 699
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
861-1362 5.13e-08

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 58.06  E-value: 5.13e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  861 EKHQKELLSLKNEYEGKLDGLIKETEENENKiKKLKGELVCLEEVLQNKDNEFALVKHEKEavicLQNEKDQKLLEMENI 940
Cdd:TIGR00618  228 LKHLREALQQTQQSHAYLTQKREAQEEQLKK-QQLLKQLRARIEELRAQEAVLEETQERIN----RARKAAPLAAHIKAV 302
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  941 MH------SQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDhrvsL 1014
Cdd:TIGR00618  303 TQieqqaqRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTL----T 378
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1015 EELKKENQQIINQIQEShaEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLE 1094
Cdd:TIGR00618  379 QHIHTLQQQKTTLTQKL--QSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKL 456
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1095 QETE------NLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSL------- 1161
Cdd:TIGR00618  457 EKIHlqesaqSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRmqrgeqt 536
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1162 HNQAFEIEKNLKEQIIEL--QSKLDSELSALERQKDEKITQQEEKYEAII---QNLEKDRQKLVSSQEQDREQLIQKLNC 1236
Cdd:TIGR00618  537 YAQLETSEEDVYHQLTSErkQRASLKEQMQEIQQSFSILTQCDNRSKEDIpnlQNITVRLQDLTEKLSEAEDMLACEQHA 616
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1237 EKDEA-IQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNE 1315
Cdd:TIGR00618  617 LLRKLqPEQDLQDVRLHLQQCSQELALKLTALHALQLTLTQERVREHALSIRVLPKELLASRQLALQKMQSEKEQLTYWK 696
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*..
gi 1034662293 1316 EMQNVRTSLIAEQQTnfnTVLTREKMRKEniINDLSDKLKSTMQQQE 1362
Cdd:TIGR00618  697 EMLAQCQTLLRELET---HIEEYDREFNE--IENASSSLGSDLAARE 738
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
840-1316 5.90e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 57.75  E-value: 5.90e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  840 TAVEIRNIIEKVKCSLEITLKEkhQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHE 919
Cdd:TIGR00606  689 TEAELQEFISDLQSKLRLAPDK--LKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKND 766
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  920 KEaviclqneKDQKLLEMENimhsQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQShlkeledtlqvRH 999
Cdd:TIGR00606  767 IE--------EQETLLGTIM----PEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGSDLD-----------RT 823
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1000 IQEFEKVMTDhrvsleelKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELAlkeaetdeikille 1079
Cdd:TIGR00606  824 VQQVNQEKQE--------KQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQ-------------- 881
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1080 esRAQQketlkslLEQETENLRTEISKLNQKIQDNNENyqvglaELRTLMTIEKDQC-ISELISRHEEESNILKAELN-- 1156
Cdd:TIGR00606  882 --RRQQ-------FEEQLVELSTEVQSLIREIKDAKEQ------DSPLETFLEKDQQeKEELISSKETSNKKAQDKVNdi 946
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1157 --KVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEkitqQEEKYEAIIQNLEKDRQKLVSSQEQDReQLIQKL 1234
Cdd:TIGR00606  947 keKVKNIHGYMKDIENKIQDGKDDYLKQKETELNTVNAQLEE----CEKHQEKINEDMRLMRQDIDTQKIQER-WLQDNL 1021
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1235 NCEKdeaIQTALKEFKLEREVVEKELLE-KVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRK 1313
Cdd:TIGR00606 1022 TLRK---RENELKEVEEELKQHLKEMGQmQVLQMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELREPQFRD 1098

                   ...
gi 1034662293 1314 NEE 1316
Cdd:TIGR00606 1099 AEE 1101
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
861-1273 5.98e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 57.64  E-value: 5.98e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  861 EKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENI 940
Cdd:COG1196    315 EERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRA 394
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  941 MHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKE 1020
Cdd:COG1196    395 AAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAAL 474
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1021 NQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTR--------------------CKLEVELALKEA----------E 1070
Cdd:COG1196    475 LEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKaalllaglrglagavavligVEAAYEAALEAAlaaalqnivvE 554
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1071 TDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQK--------------IQDNNENYQVGLAELRTLMTIEKDQC 1136
Cdd:COG1196    555 DDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARgaigaavdlvasdlREADARYYVLGDTLLGRTLVAARLEA 634
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1137 ISELISRHEEESNILKAELNKVTSLHNQAFEIEKNL-------KEQIIELQSKLDSELSALERQKDEKITQQEEKYEAII 1209
Cdd:COG1196    635 ALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELlaalleaEAELEELAERLAEEELELEEALLAEEEEERELAEAEE 714
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034662293 1210 QNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAK 1273
Cdd:COG1196    715 ERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEA 778
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
815-1394 6.23e-08

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 58.14  E-value: 6.23e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  815 IKEDLCH--FRTFVQKEQCDFSNSLKCTAVEIRNIIEKVkcsleitlkEKHQKELLSLKNEyegkldgliketeeNENKI 892
Cdd:TIGR01612 1089 IKEKLKHynFDDFGKEENIKYADEINKIKDDIKNLDQKI---------DHHIKALEEIKKK--------------SENYI 1145
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  893 KKLKGELVCLEEVLQNK-DNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVL-------EDLKK 964
Cdd:TIGR01612 1146 DEIKAQINDLEDVADKAiSNDDPEEIEKKIENIVTKIDKKKNIYDEIKKLLNEIAEIEKDKTSLEEVKginlsygKNLGK 1225
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  965 LHVEN-DEKLQLLRAELQSLEqSHLKELEDTL-QVRHIQEFEKVMTDHRVSLEEL-----KKENQQIINQIQESHAEIIQ 1037
Cdd:TIGR01612 1226 LFLEKiDEEKKKSEHMIKAME-AYIEDLDEIKeKSPEIENEMGIEMDIKAEMETFnishdDDKDHHIISKKHDENISDIR 1304
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1038 EKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESraqqkETLKSLLE-QETENLRTEISKLNQKIQDNNE 1116
Cdd:TIGR01612 1305 EKSLKIIEDFSEESDINDIKKELQKNLLDAQKHNSDINLYLNEI-----ANIYNILKlNKIKKIIDEVKEYTKEIEENNK 1379
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1117 NYQVGLAELRTLM-TIEKDQCISELISRHE------------------------EESNI-----LKAELNKVTSLHNQAF 1166
Cdd:TIGR01612 1380 NIKDELDKSEKLIkKIKDDINLEECKSKIEstlddkdidecikkikelknhilsEESNIdtyfkNADENNENVLLLFKNI 1459
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1167 EIEKNLKEQIIELQ-----SKLDSELSALERQKD---------EKITQQEEKYEAIIQNLEKDRQKL------------V 1220
Cdd:TIGR01612 1460 EMADNKSQHILKIKkdnatNDHDFNINELKEHIDkskgckdeaDKNAKAIEKNKELFEQYKKDVTELlnkysalaiknkF 1539
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1221 SSQEQDREQLIQKlncekdeaIQTALKEFKLEREVVEKELlEKVKH----LENQIAKSpaidstrGDSSSLVAELQEKLQ 1296
Cdd:TIGR01612 1540 AKTKKDSEIIIKE--------IKDAHKKFILEAEKSEQKI-KEIKKekfrIEDDAAKN-------DKSNKAAIDIQLSLE 1603
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1297 EEKAKFLeQLEEQEKRKNEEMQnvRTSLIAEQQTNFNtvltrekmrkeniINDLSDKLKSTMQQQERDKDLIESLSEDRA 1376
Cdd:TIGR01612 1604 NFENKFL-KISDIKKKINDCLK--ETESIEKKISSFS-------------IDSQDTELKENGDNLNSLQEFLESLKDQKK 1667
                          650
                   ....*....|....*...
gi 1034662293 1377 RLLEEKKKLEEEVSKLRS 1394
Cdd:TIGR01612 1668 NIEDKKKELDELDSEIEK 1685
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1068-1397 7.53e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 57.37  E-value: 7.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1068 EAETDEIKILLEES------RAQQKETLKSLLEQET-----ENLRTEISKLNQKIQDnnenyQVGLAE-LRTLMTIEKDQ 1135
Cdd:TIGR02168  151 EAKPEERRAIFEEAagiskyKERRKETERKLERTREnldrlEDILNELERQLKSLER-----QAEKAErYKELKAELREL 225
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1136 CISELISRHEEesniLKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLdSELSALERQKDEKITQQEEKYEAI---IQNL 1212
Cdd:TIGR02168  226 ELALLVLRLEE----LREELEELQEELKEAEEELEELTAELQELEEKL-EELRLEVSELEEEIEELQKELYALaneISRL 300
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1213 EKDRQKLVSSQEQDREQLIQK-LNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAidsTRGDSSSLVAEL 1291
Cdd:TIGR02168  301 EQQKQILRERLANLERQLEELeAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEA---ELEELESRLEEL 377
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1292 QEKLQEEKAKFLeQLEEQEKRKNEEMQNVRTSL--IAEQQTNFNTVLT-----REKMRKENIINDLSDKLKSTMQQQERD 1364
Cdd:TIGR02168  378 EEQLETLRSKVA-QLELQIASLNNEIERLEARLerLEDRRERLQQEIEellkkLEEAELKELQAELEELEEELEELQEEL 456
                          330       340       350
                   ....*....|....*....|....*....|...
gi 1034662293 1365 KDLIESLSEDRARLLEEKKKLEEEVSKLRSSSF 1397
Cdd:TIGR02168  457 ERLEEALEELREELEEAEQALDAAERELAQLQA 489
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1080-1330 8.14e-08

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 56.38  E-value: 8.14e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1080 ESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLmtiekdqciselisrhEEESNILKAELNKVT 1159
Cdd:COG3883     15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEAL----------------QAEIDKLQAEIAEAE 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1160 SLHNQAFEIeknLKEQIIELQ--SKLDSELSALERQKD--EKITQQEekyeaIIQNLEKDRQKLVSSQEQDREQLiqkln 1235
Cdd:COG3883     79 AEIEERREE---LGERARALYrsGGSVSYLDVLLGSESfsDFLDRLS-----ALSKIADADADLLEELKADKAEL----- 145
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1236 cekdEAIQTALKEFKLEREVVEKELLEKVKHLENQIAkspaidstrgDSSSLVAEL---QEKLQEEKAKFLEQLEEQEKR 1312
Cdd:COG3883    146 ----EAKKAELEAKLAELEALKAELEAAKAELEAQQA----------EQEALLAQLsaeEAAAEAQLAELEAELAAAEAA 211
                          250
                   ....*....|....*...
gi 1034662293 1313 KNEEMQNVRTSLIAEQQT 1330
Cdd:COG3883    212 AAAAAAAAAAAAAAAAAA 229
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1034-1375 8.60e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 57.39  E-value: 8.60e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1034 EIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEaETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQD 1113
Cdd:TIGR02169  177 EELEEVEENIERLDLIIDEKRQQLERLRREREKAE-RYQALLKEKREYEGYELLKEKEALERQKEAIERQLASLEEELEK 255
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1114 nnenyqvglaelrtlmtiekdqcISELISRHEEESNILKAELNKVTSlhnqafEIEKNLKEQIIELQSKLDS---ELSAL 1190
Cdd:TIGR02169  256 -----------------------LTEEISELEKRLEEIEQLLEELNK------KIKDLGEEEQLRVKEKIGEleaEIASL 306
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1191 ERQKDEKITQQEEkyeaiiqnLEKDRQKLVSSQEQDREQLiqklncekdEAIQTALKEFKLEREVVEKELLEKVKHLEnq 1270
Cdd:TIGR02169  307 ERSIAEKERELED--------AEERLAKLEAEIDKLLAEI---------EELEREIEEERKRRDKLTEEYAELKEELE-- 367
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1271 iakspaidstrgdssSLVAELQEKLQEEKAKFLEQLEEQEKRknEEMQNVRTSLIAEQQTNFNTvLTREKMRKENIINDL 1350
Cdd:TIGR02169  368 ---------------DLRAELEEVDKEFAETRDELKDYREKL--EKLKREINELKRELDRLQEE-LQRLSEELADLNAAI 429
                          330       340
                   ....*....|....*....|....*
gi 1034662293 1351 SDKLKSTMQQQERDKDLIESLSEDR 1375
Cdd:TIGR02169  430 AGIEAKINELEEEKEDKALEIKKQE 454
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
834-1254 1.82e-07

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 55.73  E-value: 1.82e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  834 SNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGK-LDGLIKETEENENKIKKLKG-ELVCLEEVLQNKDN 911
Cdd:COG5185    139 KVEKLDEIADIEASYGEVETGIIKDIFGKLTQELNQNLKKLEIFgLTLGLLKGISELKKAEPSGTvNSIKESETGNLGSE 218
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  912 EFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKE-LKQSREIVLEDLKKlHVENDEKLQLLRAELQSLEQSHLKE 990
Cdd:COG5185    219 STLLEKAKEIINIEEALKGFQDPESELEDLAQTSDKLEKlVEQNTDLRLEKLGE-NAESSKRLNENANNLIKQFENTKEK 297
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  991 LEDTLQ----VRHIQEFEKVM--TDHRVSLEELKKENQQIINQIQEshaEIIQEKEKQLQELKLKVSDLSdtRCKLEVEL 1064
Cdd:COG5185    298 IAEYTKsidiKKATESLEEQLaaAEAEQELEESKRETETGIQNLTA---EIEQGQESLTENLEAIKEEIE--NIVGEVEL 372
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1065 ALKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEISklNQKIQDNNenyqvgLAELRTlmtiekdqCISELISRH 1144
Cdd:COG5185    373 SKSSEELDSFKDTIESTKESLDEIPQNQRGYAQEILATLED--TLKAADRQ------IEELQR--------QIEQATSSN 436
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1145 EEESNILKAELNkvtSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQE 1224
Cdd:COG5185    437 EEVSKLLNELIS---ELNKVMREADEESQSRLEEAYDEINRSVRSKKEDLNEELTQIESRVSTLKATLEKLRAKLERQLE 513
                          410       420       430
                   ....*....|....*....|....*....|
gi 1034662293 1225 QDREQLIQKLNCEKDEAIQTALKEFKLERE 1254
Cdd:COG5185    514 GVRSKLDQVAESLKDFMRARGYAHILALEN 543
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
947-1375 1.83e-07

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 56.20  E-value: 1.83e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  947 EIKELKQSREIV---LEDLKKLHVENDEKlqllRAELQSLEQShLKELEDTLQ--VRHIQEFEKVMTDHRVSLEELKKEN 1021
Cdd:PRK02224   221 EIERYEEQREQAretRDEADEVLEEHEER----REELETLEAE-IEDLRETIAetEREREELAEEVRDLRERLEELEEER 295
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1022 QQIINQIQESHAEIiQEKEKQLQELKLKVSDLSDT--RCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETEN 1099
Cdd:PRK02224   296 DDLLAEAGLDDADA-EAVEARREELEDRDEELRDRleECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEE 374
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1100 LRTEISKLNQKIQDNNEnyqvglaELRTLmtiekdqciselisrhEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIEL 1179
Cdd:PRK02224   375 AREAVEDRREEIEELEE-------EIEEL----------------RERFGDAPVDLGNAEDFLEELREERDELREREAEL 431
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1180 QSKLDSELSALErqKDEKITQ--------QEEKYEAIIQNLEKDRQKlVSSQEQDREQLIQKLNcEKDEAIQTALKEFKL 1251
Cdd:PRK02224   432 EATLRTARERVE--EAEALLEagkcpecgQPVEGSPHVETIEEDRER-VEELEAELEDLEEEVE-EVEERLERAEDLVEA 507
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1252 EREVveKELLEKVKHLENQIA--------KSPAIDSTRGDSSSLVAELQEK------LQEEKAKFLEQLEEQEKRKN--- 1314
Cdd:PRK02224   508 EDRI--ERLEERREDLEELIAerretieeKRERAEELRERAAELEAEAEEKreaaaeAEEEAEEAREEVAELNSKLAelk 585
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034662293 1315 ---EEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLS-DKLKStmqQQERDKDLIESLSEDR 1375
Cdd:PRK02224   586 eriESLERIRTLLAAIADAEDEIERLREKREALAELNDERrERLAE---KRERKRELEAEFDEAR 647
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
1123-1265 4.87e-07

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 54.83  E-value: 4.87e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1123 AELRTLMTIEKDQcISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQE 1202
Cdd:PRK00409   505 EEAKKLIGEDKEK-LNELIASLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEAEKEAQQAIKEAK 583
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034662293 1203 EKYEAIIQNLEKDRQKLVSSQ-EQDREQLIQKLNcekdEAIQTALKEFKLEREVVEK-ELLEKVK 1265
Cdd:PRK00409   584 KEADEIIKELRQLQKGGYASVkAHELIEARKRLN----KANEKKEKKKKKQKEKQEElKVGDEVK 644
EzrA COG4477
Septation ring formation regulator EzrA [Cell cycle control, cell division, chromosome ...
928-1306 6.18e-07

Septation ring formation regulator EzrA [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443574 [Multi-domain]  Cd Length: 567  Bit Score: 54.08  E-value: 6.18e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  928 NEKDQKLLEMENIMHSQNCEIKELKQSreivLEDLKKLHVENDEKLQLLRAELqsLEQSH-----LKELEDTLQV--RHI 1000
Cdd:COG4477    107 DEIEQLLDEIEEEIEEILEELEELLES----EEKNREEIEELKEKYRELRKTL--LAHRHsfgpaAEELEKQLEElePEF 180
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1001 QEFEKVMT--DH---RVSLEELKKEN---QQIINQIQESHAEIIQEKEKQLQELK---------------LKV-SDLSDT 1056
Cdd:COG4477    181 EEFEELTEsgDYleaREILEQLEEELnalEELMEEIPPLLKELQTELPDQLEELKsgyremkeqgyvlehLNIeKEIEQL 260
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1057 RCKL-EVELALKEAETDEIKILLEESrAQQKETLKSLLEQE------TENLRTEISKLNQKIQDNNENYQVGLAELRTLM 1129
Cdd:COG4477    261 EEQLkEALELLEELDLDEAEEELEEI-EEEIDELYDLLEKEveakkyVDKNQEELEEYLEHLKEQNRELKEEIDRVQQSY 339
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1130 TIekdqciselisrHEEESNILKAELNKVTSLHNQAFEIEKNLKEQII---ELQSKLDSElsalerqkDEKITQQEEKYE 1206
Cdd:COG4477    340 RL------------NENELEKVRNLEKQIEELEKRYDEIDERIEEEKVaysELQEELEEI--------EEQLEEIEEEQE 399
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1207 AI---IQNLEKD----RQKLVSSQEQDRE--QLIQKLNcekdeaIQTALKEFKLEREVVEkellEKVKHLENQIAKSP-- 1275
Cdd:COG4477    400 EFsekLKSLRKDeleaREKLDELKKKLREikRRLEKSN------LPGLPEEYLEMFEEAS----DEIEELSEELNEVPln 469
                          410       420       430
                   ....*....|....*....|....*....|....*
gi 1034662293 1276 --AIDSTRGDSSSLVAELQEKLQE--EKAKFLEQL 1306
Cdd:COG4477    470 mdEVNRLLEEAEEDIETLEEKTEElvENATLTERL 504
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
947-1374 6.28e-07

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 54.59  E-value: 6.28e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  947 EIKELKQSREIVLEDLKKlHVENDEKLQLLRAELQSLEQsHLKELEDTLqvrhiqefekvmTDHRVSLEELKKENQQIIN 1026
Cdd:TIGR00618  171 NLFPLDQYTQLALMEFAK-KKSLHGKAELLTLRSQLLTL-CTPCMPDTY------------HERKQVLEKELKHLREALQ 236
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1027 QIQESHAEIIQEKEKQLQELKLKvSDLSDTRCKLEvELALKEAETDEikilLEESRAQQKETLKSLLEQEtenlrtEISK 1106
Cdd:TIGR00618  237 QTQQSHAYLTQKREAQEEQLKKQ-QLLKQLRARIE-ELRAQEAVLEE----TQERINRARKAAPLAAHIK------AVTQ 304
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1107 LNQKIQDNNENYQVGLAEL-RTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQA------FEIEKNLKEQIIEL 1179
Cdd:TIGR00618  305 IEQQAQRIHTELQSKMRSRaKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVAtsireiSCQQHTLTQHIHTL 384
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1180 QSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKD--RQKLVSSQEQdrEQLIQKLNCEKDEAIQTALKEFKLeREVVE 1257
Cdd:TIGR00618  385 QQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRdlQGQLAHAKKQ--QELQQRYAELCAAAITCTAQCEKL-EKIHL 461
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1258 KELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAkfleQLEEQEKRKNEEMQNvrtSLIAEQQTNFNTVLT 1337
Cdd:TIGR00618  462 QESAQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPC----PLCGSCIHPNPARQD---IDNPGPLTRRMQRGE 534
                          410       420       430
                   ....*....|....*....|....*....|....*..
gi 1034662293 1338 REKMRKENIINDLSDKLKSTMQQQERDKDLIESLSED 1374
Cdd:TIGR00618  535 QTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQS 571
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
845-1262 6.62e-07

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 54.67  E-value: 6.62e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  845 RNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGliKETEENENKIKKLKGELVCLEevlQNKDNEFALVKHEKEAV- 923
Cdd:TIGR01612 1379 KNIKDELDKSEKLIKKIKDDINLEECKSKIESTLDD--KDIDECIKKIKELKNHILSEE---SNIDTYFKNADENNENVl 1453
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  924 -----ICLQNEKDQKLLEME--NIMHSQNCEIKELKQSREivleDLKKLHVENDEKLQLLRAELQSLEQsHLKELEDTLQ 996
Cdd:TIGR01612 1454 llfknIEMADNKSQHILKIKkdNATNDHDFNINELKEHID----KSKGCKDEADKNAKAIEKNKELFEQ-YKKDVTELLN 1528
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  997 VRHIQEFEKvmtdhrvSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKlkvsdlsdtrcklevelalkeaETDEIKI 1076
Cdd:TIGR01612 1529 KYSALAIKN-------KFAKTKKDSEIIIKEIKDAHKKFILEAEKSEQKIK----------------------EIKKEKF 1579
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1077 LLEESRAQQKETLKSLLEQET--ENLRT---EISKLNQKIQDNnenyqvglaeLRTLMTIEKDqcISEL-ISRHEEESNI 1150
Cdd:TIGR01612 1580 RIEDDAAKNDKSNKAAIDIQLslENFENkflKISDIKKKINDC----------LKETESIEKK--ISSFsIDSQDTELKE 1647
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1151 LKAELNKVT----SLHNQafeiEKNLKEQIIELqSKLDSELSALERQKDekitQQEEKYE-AIIQNLEK----DRQKLVS 1221
Cdd:TIGR01612 1648 NGDNLNSLQefleSLKDQ----KKNIEDKKKEL-DELDSEIEKIEIDVD----QHKKNYEiGIIEKIKEiaiaNKEEIES 1718
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*.
gi 1034662293 1222 SQEQDR---EQLIQKLNCEKDEAIQT--ALKEFKLEREVVEKELLE 1262
Cdd:TIGR01612 1719 IKELIEptiENLISSFNTNDLEGIDPneKLEEYNTEIGDIYEEFIE 1764
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
1081-1377 7.55e-07

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 53.97  E-value: 7.55e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1081 SRAQQKETLKSLleqETENLRTEISKLNQKIQDNNEnyqvgLAELRTLMTIEKDQcISELISRHEEESNILKAELNKVtS 1160
Cdd:pfam17380  285 SERQQQEKFEKM---EQERLRQEKEEKAREVERRRK-----LEEAEKARQAEMDR-QAAIYAEQERMAMERERELERI-R 354
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1161 LHNQAFEIEKNLKEQI-IELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKD 1239
Cdd:pfam17380  355 QEERKRELERIRQEEIaMEISRMRELERLQMERQQKNERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQ 434
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1240 EAIQTALKEFKLEREVVEKELLEKVKHLEnQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQN 1319
Cdd:pfam17380  435 REVRRLEEERAREMERVRLEEQERQQQVE-RLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEER 513
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034662293 1320 VRTSLIAEQQTNFNTVLTREKMRKEniinDLSDKLKSTMQQQERDKDLIESLSEDRAR 1377
Cdd:pfam17380  514 KRKLLEKEMEERQKAIYEEERRREA----EEERRKQQEMEERRRIQEQMRKATEERSR 567
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
1001-1367 7.80e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 53.97  E-value: 7.80e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1001 QEFEKVMTDHRVSLEELKKEnqqiINQIQESHaeiiqekEKQLQELKLKVSDLSDTRCKLEVElalKEAETDeikilLEE 1080
Cdd:pfam15921   74 EHIERVLEEYSHQVKDLQRR----LNESNELH-------EKQKFYLRQSVIDLQTKLQEMQME---RDAMAD-----IRR 134
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1081 SRAQQKETLKSLLEQETENLrtEISKLNQKIQDNNENYQVglAELRTLMTIEKD--QCISELISRHEEESNILKAELNKV 1158
Cdd:pfam15921  135 RESQSQEDLRNQLQNTVHEL--EAAKCLKEDMLEDSNTQI--EQLRKMMLSHEGvlQEIRSILVDFEEASGKKIYEHDSM 210
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1159 TSLHNqafeieKNLKEQIIELQSKLDSELSALErqkdEKITQQEEKYEAIiQNLEKDRQKLVSSQEQDR-EQLIQKLN-- 1235
Cdd:pfam15921  211 STMHF------RSLGSAISKILRELDTEISYLK----GRIFPVEDQLEAL-KSESQNKIELLLQQHQDRiEQLISEHEve 279
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1236 ----CEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAkspaidstrgDSSSLVAELQEKLQEEKAKFLEQLEEQEK 1311
Cdd:pfam15921  280 itglTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLS----------DLESTVSQLRSELREAKRMYEDKIEELEK 349
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034662293 1312 R---KNEEMQNVRTS--LIAEQQTNFNTVLtrekmrkENIINDLSDKLKSTMQQQERDKDL 1367
Cdd:pfam15921  350 QlvlANSELTEARTErdQFSQESGNLDDQL-------QKLLADLHKREKELSLEKEQNKRL 403
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
927-1113 1.43e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.46  E-value: 1.43e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  927 QNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLhvenDEKLQLLRAELQSLEQShLKELEDTlqvrhIQEFEKV 1006
Cdd:COG4942     22 AAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAAL----ERRIAALARRIRALEQE-LAALEAE-----LAELEKE 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1007 MTDHRVSLEELKKENQQIINQIQES------------------------HAEIIQEKEKQLQELKLKVSDLSDTRCKLEV 1062
Cdd:COG4942     92 IAELRAELEAQKEELAELLRALYRLgrqpplalllspedfldavrrlqyLKYLAPARREQAEELRADLAELAALRAELEA 171
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1034662293 1063 ELALKEAETDEIKIL---LEESRAQQKETLKSlLEQETENLRTEISKLNQKIQD 1113
Cdd:COG4942    172 ERAELEALLAELEEEraaLEALKAERQKLLAR-LEKELAELAAELAELQQEAEE 224
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
854-1354 3.68e-06

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 51.98  E-value: 3.68e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  854 SLEITLKEKHQKelLSLKNEYEGKLDGLIKETEENENKIKKL-KGELVCLEEVLQNKDNEFALVKHEKEAVicLQNEKDQ 932
Cdd:TIGR01612  600 KLKLELKEKIKN--ISDKNEYIKKAIDLKKIIENNNAYIDELaKISPYQVPEHLKNKDKIYSTIKSELSKI--YEDDIDA 675
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  933 KLLEMENIMHSQNCEIKELKQSreivLEDLKKLHVENDEKLQLLRAELQSLEQSHLK----ELEDTLQVRHIQEFEKVMT 1008
Cdd:TIGR01612  676 LYNELSSIVKENAIDNTEDKAK----LDDLKSKIDKEYDKIQNMETATVELHLSNIEnkknELLDIIVEIKKHIHGEINK 751
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1009 DHRVSLEELKKENQQIINQIQESHAEiiqekEKQLQELKLKVSDL-------------SDTRCKLEVE--------LALK 1067
Cdd:TIGR01612  752 DLNKILEDFKNKEKELSNKINDYAKE-----KDELNKYKSKISEIknhyndqinidniKDEDAKQNYDkskeyiktISIK 826
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1068 EAET----DEIKILLEESRAQ----------QKETLKSLLEQETE---NLRTEISKLNQKIQDNNENYQVGL-------- 1122
Cdd:TIGR01612  827 EDEIfkiiNEMKFMKDDFLNKvdkfinfennCKEKIDSEHEQFAEltnKIKAEISDDKLNDYEKKFNDSKSLineinksi 906
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1123 -AELRTLMTIEK-DQCI------SELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQiieLQSKLDSELSALERQ- 1193
Cdd:TIGR01612  907 eEEYQNINTLKKvDEYIkicentKESIEKFHNKQNILKEILNKNIDTIKESNLIEKSYKDK---FDNTLIDKINELDKAf 983
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1194 KDEKITQQEEKYEAIIQ-------NLEKDRQKLVSSQEQDREQ----LIQKL-NCEK-----DEAIQTALKEFKLErevV 1256
Cdd:TIGR01612  984 KDASLNDYEAKNNELIKyfndlkaNLGKNKENMLYHQFDEKEKatndIEQKIeDANKnipniEIAIHTSIYNIIDE---I 1060
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1257 EKELLEKVKHLENQIAKSPAIDSTRGDssslvaELQEKLQEekAKFLEQLEEQEKRKNEEMQNVRTSL-IAEQQTNFN-T 1334
Cdd:TIGR01612 1061 EKEIGKNIELLNKEILEEAEINITNFN------EIKEKLKH--YNFDDFGKEENIKYADEINKIKDDIkNLDQKIDHHiK 1132
                          570       580
                   ....*....|....*....|
gi 1034662293 1335 VLTREKMRKENIINDLSDKL 1354
Cdd:TIGR01612 1133 ALEEIKKKSENYIDEIKAQI 1152
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
776-1257 3.71e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 51.65  E-value: 3.71e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  776 RMQDTNVCGKEDFGDHtsLNVQLERCRVVAQDSHFSIQTIKEDL-CHFRTFVQ-----KEQCDFSNSLKCTAVEIRNIIE 849
Cdd:pfam05483  278 KLQDENLKELIEKKDH--LTKELEDIKMSLQRSMSTQKALEEDLqIATKTICQlteekEAQMEELNKAKAAHSFVVTEFE 355
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  850 KVKCSLEITLKEKHQK-----------------------ELLSLKNEYEGKLD----------GLIKETEENENKIKKLK 896
Cdd:pfam05483  356 ATTCSLEELLRTEQQRleknedqlkiitmelqkksseleEMTKFKNNKEVELEelkkilaedeKLLDEKKQFEKIAEELK 435
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  897 GELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLL 976
Cdd:pfam05483  436 GKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLEL 515
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  977 RAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSL-EELKKENQQI---INQIQESHAEIIQEKEKQLQELKLKVSD 1052
Cdd:pfam05483  516 KKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVrEEFIQKGDEVkckLDKSEENARSIEYEVLKKEKQMKILENK 595
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1053 LSDTRCKLEVELALKEAETDEIKILLEESRAQQKETlkSLLEQETENLRTEISKLNQKIQDNNENYQvglaelrtlmtie 1132
Cdd:pfam05483  596 CNNLKKQIENKNKNIEELHQENKALKKKGSAENKQL--NAYEIKVNKLELELASAKQKFEEIIDNYQ------------- 660
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1133 kdqciSELISRHEEESNILKaELNKVTSLHNQAFEIEKNLKEQIielQSKLDSELSALERQKDE--KITQQEEKYEAIIQ 1210
Cdd:pfam05483  661 -----KEIEDKKISEEKLLE-EVEKAKAIADEAVKLQKEIDKRC---QHKIAEMVALMEKHKHQydKIIEERDSELGLYK 731
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*...
gi 1034662293 1211 NLEKDRQKLVSSQEQDREQLIQKL-NCEKDEAIQTALKEfKLEREVVE 1257
Cdd:pfam05483  732 NKEQEQSSAKAALEIELSNIKAELlSLKKQLEIEKEEKE-KLKMEAKE 778
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
951-1216 4.93e-06

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 51.08  E-value: 4.93e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  951 LKQSREIVLEDLKKL---HVEN------DEKLQLLRAELQSLEQsHLKELEDTLQVRHIqEFEKVMTDHRVSLEELKKEN 1021
Cdd:PRK05771    14 LKSYKDEVLEALHELgvvHIEDlkeelsNERLRKLRSLLTKLSE-ALDKLRSYLPKLNP-LREEKKKVSVKSLEELIKDV 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1022 QQIINQIQEShaeiIQEKEKQLQELKLKVSDLSDTRCKLE----VELALKEAETDE-IKILLEESRAQQKETLKSLLEQE 1096
Cdd:PRK05771    92 EEELEKIEKE----IKELEEEISELENEIKELEQEIERLEpwgnFDLDLSLLLGFKyVSVFVGTVPEDKLEELKLESDVE 167
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1097 TEnlrTEISKLNQK----IQDNNENYQVGLAELRTL----MTIEKDQCISELISRHEEESNILKAELNKvtslhnqafei 1168
Cdd:PRK05771   168 NV---EYISTDKGYvyvvVVVLKELSDEVEEELKKLgferLELEEEGTPSELIREIKEELEEIEKERES----------- 233
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 1034662293 1169 eknLKEQIIELQSKLDSELSALErqkdEKITQQEEKYEAIIQNLEKDR 1216
Cdd:PRK05771   234 ---LLEELKELAKKYLEELLALY----EYLEIELERAEALSKFLKTDK 274
PLN02939 PLN02939
transferase, transferring glycosyl groups
949-1316 6.24e-06

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 51.06  E-value: 6.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  949 KELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKEL--EDTLQVRHIQEFEKVMTDHRVSLEELKKENQqiIN 1026
Cdd:PLN02939    49 KRGKNIAPKQRSSNSKLQSNTDENGQLENTSLRTVMELPQKSTssDDDHNRASMQRDEAIAAIDNEQQTNSKDGEQ--LS 126
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1027 QIQ-ESHAEIIQEKEKQLQEL-KLKVSDLSDtrckLEVELALKEAETDEIKIL---LEESRAQQKETLK-----SLLEQE 1096
Cdd:PLN02939   127 DFQlEDLVGMIQNAEKNILLLnQARLQALED----LEKILTEKEALQGKINILemrLSETDARIKLAAQekihvEILEEQ 202
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1097 TENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDqciselisrheeESNILKAELNKVTSLHNQAFEIEKN---LK 1173
Cdd:PLN02939   203 LEKLRNELLIRGATEGLCVHSLSKELDVLKEENMLLKD------------DIQFLKAELIEVAETEERVFKLEKErslLD 270
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1174 EQIIELQSKL---DSELSALERQKDE--------------KITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNC 1236
Cdd:PLN02939   271 ASLRELESKFivaQEDVSKLSPLQYDcwwekvenlqdlldRATNQVEKAALVLDQNQDLRDKVDKLEASLKEANVSKFSS 350
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1237 EKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIakspaidstrgdssslvAELQEKLQEEKakfleqlEEQEKRKNEE 1316
Cdd:PLN02939   351 YKVELLQQKLKLLEERLQASDHEIHSYIQLYQESI-----------------KEFQDTLSKLK-------EESKKRSLEH 406
PRK01156 PRK01156
chromosome segregation protein; Provisional
870-1116 6.74e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 51.06  E-value: 6.74e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  870 LKNEYEGKLDGLIKETEENENKIKKLKgelvclEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNcEIK 949
Cdd:PRK01156   470 IINHYNEKKSRLEEKIREIEIEVKDID------EKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKIN-ELK 542
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  950 ELKQSREIVLEDLKKLHVE-----NDEKLQLLrAELQSLE-----------QSHLKELEDTLQvRHIQEFEKVMTDHRVS 1013
Cdd:PRK01156   543 DKHDKYEEIKNRYKSLKLEdldskRTSWLNAL-AVISLIDietnrsrsneiKKQLNDLESRLQ-EIEIGFPDDKSYIDKS 620
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1014 LEELKKENQQIINQIQEshaeiIQEKEKQLQELKLKVSDLSDTRCKL-EVELALKE--AETDEIKILLEESRAQQKETLK 1090
Cdd:PRK01156   621 IREIENEANNLNNKYNE-----IQENKILIEKLRGKIDNYKKQIAEIdSIIPDLKEitSRINDIEDNLKKSRKALDDAKA 695
                          250       260
                   ....*....|....*....|....*...
gi 1034662293 1091 SLLEQET--ENLRTEISKLNQKIQDNNE 1116
Cdd:PRK01156   696 NRARLEStiEILRTRINELSDRINDINE 723
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
838-1318 8.71e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 50.74  E-value: 8.71e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  838 KCTAVEIRNIIEKVKCSLEITL-KEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALV 916
Cdd:TIGR00618  371 SCQQHTLTQHIHTLQQQKTTLTqKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCT 450
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  917 KHEKEAVICLQNEKDQKLLEMENIMHSQNC---EIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSL-----EQSHL 988
Cdd:TIGR00618  451 AQCEKLEKIHLQESAQSLKEREQQLQTKEQihlQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIdnpgpLTRRM 530
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  989 KELEDTLQvRHIQEFEKV------MTDHRVSLEE----LKKENQQIINQIQESHAEI--IQEKEKQLQELKLKVSDLSDT 1056
Cdd:TIGR00618  531 QRGEQTYA-QLETSEEDVyhqltsERKQRASLKEqmqeIQQSFSILTQCDNRSKEDIpnLQNITVRLQDLTEKLSEAEDM 609
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1057 -RCKLEVELALKEAETDEIKILLEESRAQQKETLKSL-LEQETENL---RTEISKLNQKIQDNNENYQVGLAELRTLMTI 1131
Cdd:TIGR00618  610 lACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTaLHALQLTLtqeRVREHALSIRVLPKELLASRQLALQKMQSEK 689
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1132 EKDQCISELISRHEEesnILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDS---ELSALERQKDEKITQQEEKYEAI 1208
Cdd:TIGR00618  690 EQLTYWKEMLAQCQT---LLRELETHIEEYDREFNEIENASSSLGSDLAAREDAlnqSLKELMHQARTVLKARTEAHFNN 766
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1209 IQNLEKDRQKLvsSQEQDREQLIQKLNcEKDEAIQTALKEfklerevVEKELLEKVKHLENqiAKSPAIDSTRGDSSSLV 1288
Cdd:TIGR00618  767 NEEVTAALQTG--AELSHLAAEIQFFN-RLREEDTHLLKT-------LEAEIGQEIPSDED--ILNLQCETLVQEEEQFL 834
                          490       500       510
                   ....*....|....*....|....*....|..
gi 1034662293 1289 AELQEK--LQEEKAKFLEQLEEQEKRKNEEMQ 1318
Cdd:TIGR00618  835 SRLEEKsaTLGEITHQLLKYEECSKQLAQLTQ 866
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
1004-1207 9.33e-06

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 50.41  E-value: 9.33e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1004 EKVMTDHRVSLEELKKENQQIINQIQEShaeiIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEikilLEESRA 1083
Cdd:pfam05667  316 TSSPPTKVETEEELQQQREEELEELQEQ----LEDLESSIQELEKEIKKLESSIKQVEEELEELKEQNEE----LEKQYK 387
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1084 QQKETLKsLLEQETENlrteISKLNQKIQDNNENyqvgLAELRTLMtiEKDQciSELISRHEEesniLKAELNkvtslhN 1163
Cdd:pfam05667  388 VKKKTLD-LLPDAEEN----IAKLQALVDASAQR----LVELAGQW--EKHR--VPLIEEYRA----LKEAKS------N 444
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1034662293 1164 QAFEIEKNLkEQIIELQSKLdSELSALERQKDEKITQQEEKYEA 1207
Cdd:pfam05667  445 KEDESQRKL-EEIKELREKI-KEVAEEAKQKEELYKQLVAEYER 486
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
927-1110 1.30e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 49.44  E-value: 1.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  927 QNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVEND---EKLQLLRAELQSLEQShLKELEDTL--QVRHIQ 1001
Cdd:COG3883     18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEalqAEIDKLQAEIAEAEAE-IEERREELgeRARALY 96
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1002 EFEKVMTDHRV-----SLEELKkENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRckleVELALKEAETDEIKI 1076
Cdd:COG3883     97 RSGGSVSYLDVllgseSFSDFL-DRLSALSKIADADADLLEELKADKAELEAKKAELEAKL----AELEALKAELEAAKA 171
                          170       180       190
                   ....*....|....*....|....*....|....
gi 1034662293 1077 LLEESRAQQKETLKSLLEQETENLRTEISKLNQK 1110
Cdd:COG3883    172 ELEAQQAEQEALLAQLSAEEAAAEAQLAELEAEL 205
PTZ00121 PTZ00121
MAEBL; Provisional
849-1475 1.33e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.14  E-value: 1.33e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  849 EKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKEteENENKIKKLKGelvcLEEVlqNKDNEFALvKHEKEAviclQN 928
Cdd:PTZ00121  1185 EEVRKAEELRKAEDARKAEAARKAEEERKAEEARKA--EDAKKAEAVKK----AEEA--KKDAEEAK-KAEEER----NN 1251
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  929 EKDQKLLEMENIMHSQNCEIKELKQSREIvlEDLKKlhVENDEKLQLLRAELQSLEQSHLKELEDtlQVRHIQEFEKVMT 1008
Cdd:PTZ00121  1252 EEIRKFEEARMAHFARRQAAIKAEEARKA--DELKK--AEEKKKADEAKKAEEKKKADEAKKKAE--EAKKADEAKKKAE 1325
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1009 DHRVSLEELKK--ENQQIINQIQESHAEIIQEKEKQLQElKLKVSDLSDTRCKLEVELALKEAE----TDEIKILLEESR 1082
Cdd:PTZ00121  1326 EAKKKADAAKKkaEEAKKAAEAAKAEAEAAADEAEAAEE-KAEAAEKKKEEAKKKADAAKKKAEekkkADEAKKKAEEDK 1404
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1083 AQQKETLKSLLEQ----ETENLRTEISKLNQKIQDNNENYQVGLAELRTlmtiEKDQCISELISRHEEESNILKA----- 1153
Cdd:PTZ00121  1405 KKADELKKAAAAKkkadEAKKKAEEKKKADEAKKKAEEAKKADEAKKKA----EEAKKAEEAKKKAEEAKKADEAkkkae 1480
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1154 ELNKVTSLHNQAFEIEKNLKE--QIIELQSKLDSELSALERQKDEKITQQEEKYEAiiQNLEKDRQKLVSSQEQDREQLI 1231
Cdd:PTZ00121  1481 EAKKADEAKKKAEEAKKKADEakKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKA--DEAKKAEEKKKADELKKAEELK 1558
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1232 QKLNCEK-------DEAIQTALKEFKLEREVvEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKF-- 1302
Cdd:PTZ00121  1559 KAEEKKKaeeakkaEEDKNMALRKAEEAKKA-EEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVeq 1637
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1303 LEQLEEQEKRKNEEMQNvrtsliAEQQtnfNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEK 1382
Cdd:PTZ00121  1638 LKKKEAEEKKKAEELKK------AEEE---NKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELK 1708
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1383 KKLEEEVSKlrsssfvpSPYVATAPELYGACAPELPGESDRSAvETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLL 1462
Cdd:PTZ00121  1709 KKEAEEKKK--------AEELKKAEEENKIKAEEAKKEAEEDK-KKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEA 1779
                          650
                   ....*....|...
gi 1034662293 1463 ERTLQLKEEENKR 1475
Cdd:PTZ00121  1780 VIEEELDEEDEKR 1792
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
1184-1475 1.47e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 49.74  E-value: 1.47e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1184 DSELSALERQKD-EKITQQEEKYEaiiqnLEKDRQKLVSsQEQDREQLIQKLNCEKDEAIQTALKEFKLEREV--VEKEL 1260
Cdd:pfam17380  338 EQERMAMERERElERIRQEERKRE-----LERIRQEEIA-MEISRMRELERLQMERQQKNERVRQELEAARKVkiLEEER 411
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1261 LEKVKHLENQIAKspaidsTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSliAEQQTNFNTVLTREK 1340
Cdd:pfam17380  412 QRKIQQQKVEMEQ------IRAEQEEARQREVRRLEEERAREMERVRLEEQERQQQVERLRQQ--EEERKRKKLELEKEK 483
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1341 mRKENIINDLSDKL--------KSTMQQQERDKDLIESLSEDRARlleekkkleeevsklrsssfvpspyvATAPElyga 1412
Cdd:pfam17380  484 -RDRKRAEEQRRKIlekeleerKQAMIEEERKRKLLEKEMEERQK--------------------------AIYEE---- 532
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034662293 1413 capelpgESDRSAVEtadEGRVDSAMEtSMMSVQENIHMLSEEKQRIMLLER----TLQLKEEENKR 1475
Cdd:pfam17380  533 -------ERRREAEE---ERRKQQEME-ERRRIQEQMRKATEERSRLEAMEReremMRQIVESEKAR 588
PTZ00121 PTZ00121
MAEBL; Provisional
947-1478 2.30e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.37  E-value: 2.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  947 EIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQ---------VRHIQEFEKVMTDHRVSLEEL 1017
Cdd:PTZ00121  1080 DFDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKaeearkaedARKAEEARKAEDAKRVEIARK 1159
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1018 KKENQQIINQIQESHAEIIQEKEKQLQELK-LKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQE 1096
Cdd:PTZ00121  1160 AEDARKAEEARKAEDAKKAEAARKAEEVRKaEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDA 1239
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1097 TENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELiSRHEEESNILKA----ELNKVTSLHNQAFEIEK-- 1170
Cdd:PTZ00121  1240 EEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADEL-KKAEEKKKADEAkkaeEKKKADEAKKKAEEAKKad 1318
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1171 NLKEQIIELQSKLDS-ELSALERQKDEKITQQEEKYEAiiQNLEKDRQK-----LVSSQEQDREQLIQKLNCEKDEAIQT 1244
Cdd:PTZ00121  1319 EAKKKAEEAKKKADAaKKKAEEAKKAAEAAKAEAEAAA--DEAEAAEEKaeaaeKKKEEAKKKADAAKKKAEEKKKADEA 1396
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1245 ALK--EFKLEREVVEKELLEKVKHLEnqiAKSPAIDSTRGDSSSLVAELQEKLQEEKAKfleqleEQEKRKNEEMQNVrt 1322
Cdd:PTZ00121  1397 KKKaeEDKKKADELKKAAAAKKKADE---AKKKAEEKKKADEAKKKAEEAKKADEAKKK------AEEAKKAEEAKKK-- 1465
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1323 sliAEQQTNFNTVLTREKMRKEniindlSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLeeevSKLRSSSFVPSPY 1402
Cdd:PTZ00121  1466 ---AEEAKKADEAKKKAEEAKK------ADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAE----EAKKADEAKKAEE 1532
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034662293 1403 VATAPELYGAcapelpgESDRSAVETADEGRVDSAMEtsmmsVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQ 1478
Cdd:PTZ00121  1533 AKKADEAKKA-------EEKKKADELKKAEELKKAEE-----KKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEE 1596
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
861-1071 2.56e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 2.56e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  861 EKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAvicLQNEKDQKLLEMENI 940
Cdd:COG4942     33 QQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAE---LRAELEAQKEELAEL 109
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  941 -----MHSQNCEIKELKQSREIV-----LEDLKKLHVENDEKLQLLRAELQSLEQShLKELEDtlQVRHIQEFEKVMTDH 1010
Cdd:COG4942    110 lralyRLGRQPPLALLLSPEDFLdavrrLQYLKYLAPARREQAEELRADLAELAAL-RAELEA--ERAELEALLAELEEE 186
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034662293 1011 RVSLEELKKENQQIINQIQEShaeiIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAET 1071
Cdd:COG4942    187 RAALEALKAERQKLLARLEKE----LAELAAELAELQQEAEELEALIARLEAEAAAAAERT 243
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
840-1099 2.98e-05

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 48.77  E-value: 2.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  840 TAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLeEVLQNKDNEFALVKHE 919
Cdd:PRK05771    64 SYLPKLNPLREEKKKVSVKSLEELIKDVEEELEKIEKEIKELEEEISELENEIKELEQEIERL-EPWGNFDLDLSLLLGF 142
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  920 KEAVI---CLQNEKDQKLLEMENIMHSQncEIKELKQSREIVLEDLKKLHVENDEKLQllRAELQSLEQSHLKELEDTLq 996
Cdd:PRK05771   143 KYVSVfvgTVPEDKLEELKLESDVENVE--YISTDKGYVYVVVVVLKELSDEVEEELK--KLGFERLELEEEGTPSELI- 217
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  997 vRHIQEfekvmtdhrvSLEELKKENQQIINQiqeshaeiIQEKEKQLQELKLKVSDLSDTRcKLEVELALKEAETDEIKI 1076
Cdd:PRK05771   218 -REIKE----------ELEEIEKERESLLEE--------LKELAKKYLEELLALYEYLEIE-LERAEALSKFLKTDKTFA 277
                          250       260
                   ....*....|....*....|....*.
gi 1034662293 1077 L---LEESRAqqkETLKSLLEQETEN 1099
Cdd:PRK05771   278 IegwVPEDRV---KKLKELIDKATGG 300
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
888-1316 3.45e-05

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 48.89  E-value: 3.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  888 NENKIKKLKgelvCLEEVLQnkdnEFALVKHEkeaviCLQNEKDQKLLEMEN-----------IMHSQNCEIKELKQSRE 956
Cdd:PTZ00108   968 ENGKIKKYS----DALDILK----EFYLVRLD-----LYKKRKEYLLGKLERelarlsnkvrfIKHVINGELVITNAKKK 1034
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  957 IVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDH----RVSLEELKKENqqiINQIQESH 1032
Cdd:PTZ00108  1035 DLVKELKKLGYVRFKDIIKKKSEKITAEEEEGAEEDDEADDEDDEEELGAAVSYdyllSMPIWSLTKEK---VEKLNAEL 1111
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1033 AeiiqEKEKQLQELK------LKVSDLSdtrcklEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETEnLRTEISK 1106
Cdd:PTZ00108  1112 E----KKEKELEKLKnttpkdMWLEDLD------KFEEALEEQEEVEEKEIAKEQRLKSKTKGKASKLRKPK-LKKKEKK 1180
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1107 LNQKIQDNnenyqvglaeLRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLD-- 1184
Cdd:PTZ00108  1181 KKKSSADK----------SKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNns 1250
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1185 SELSALERQKDEKITQQEEKYEAIIQNLEKDR-QKLVSSQEQDREQLIQ-------KLNCEKDEAIQTALKEFKLERevv 1256
Cdd:PTZ00108  1251 SKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQySPPPPSKRPDGESNGGskpssptKKKVKKRLEGSLAALKKKKKS--- 1327
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1257 EKELLEKVKhLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEE 1316
Cdd:PTZ00108  1328 EKKTARKKK-SKTRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSEVDDSEDEDDEDDED 1386
COG5022 COG5022
Myosin heavy chain [General function prediction only];
864-1375 3.55e-05

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 48.92  E-value: 3.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  864 QKELLSLKNEYEGKLdglIKETEENENKIKKLKgelvcleEVLQNKDNEfalvkhekeavicLQNEKDQKLLEMENIMHS 943
Cdd:COG5022    905 ESEIIELKKSLSSDL---IENLEFKTELIARLK-------KLLNNIDLE-------------EGPSIEYVKLPELNKLHE 961
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  944 QNCEIKELKQSREIVLEDLKKLHVE---NDEKLQLLRAELQSLE------QSHLKELEDTLQ--VRHIQEFEKVMTDH-- 1010
Cdd:COG5022    962 VESKLKETSEEYEDLLKKSTILVREgnkANSELKNFKKELAELSkqygalQESTKQLKELPVevAELQSASKIISSESte 1041
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1011 ---RVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSdtrckleVELALKEAETDEIKILLEESRAQQKE 1087
Cdd:COG5022   1042 lsiLKPLQKLKGLLLLENNQLQARYKALKLRRENSLLDDKQLYQLES-------TENLLKTINVKDLEVTNRNLVKPANV 1114
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1088 TLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEK----------------------------DQCISE 1139
Cdd:COG5022   1115 LQFIVAQMIKLNLLQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFweanlealpspppfaalsekrlyqsalyDEKSKL 1194
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1140 LISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIieLQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKL 1219
Cdd:COG5022   1195 SSSEVNDLKNELIALFSKIFSGWPRGDKLKKLISEGW--VPTEYSTSLKGFNNLNKKFDTPASMSNEKLLSLLNSIDNLL 1272
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1220 VSSQEQDRE------QLIQKLNCEKDEAIqtALKEFKLEREVVE------KELLEKVKHLENQIAKS------PAIDSTR 1281
Cdd:COG5022   1273 SSYKLEEEVlpatinSLLQYINVGLFNAL--RTKASSLRWKSATevnynsEELDDWCREFEISDVDEeleeliQAVKVLQ 1350
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1282 GDSSSL--VAELQEKLQEEKAKFLEQLEEQEKR-------KNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSD 1352
Cdd:COG5022   1351 LLKDDLnkLDELLDACYSLNPAEIQNLKSRYDPadkennlPKEILKKIEALLIKQELQLSLEGKDETEVHLSEIFSEEKS 1430
                          570       580
                   ....*....|....*....|....*.
gi 1034662293 1353 KL---KSTMQQQERDKDLIESLSEDR 1375
Cdd:COG5022   1431 LIsldRNSIYKEEVLSSLSALLTKEK 1456
mukB PRK04863
chromosome partition protein MukB;
948-1232 3.68e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 48.80  E-value: 3.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  948 IKELKQSREIVLEDLKKLHvENDEKLQLLRAELQSLEQSHL---------KELEDTLQ-----VRHIQEFEKVMTDHRVS 1013
Cdd:PRK04863   788 IEQLRAEREELAERYATLS-FDVQKLQRLHQAFSRFIGSHLavafeadpeAELRQLNRrrvelERALADHESQEQQQRSQ 866
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1014 LEELKkENQQIINQIQ--------ESHAEIIQEKEKQLQEL---KLKVSDLSDTRCKLEVELALKEAETDEIKIL---LE 1079
Cdd:PRK04863   867 LEQAK-EGLSALNRLLprlnlladETLADRVEEIREQLDEAeeaKRFVQQHGNALAQLEPIVSVLQSDPEQFEQLkqdYQ 945
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1080 ESRAQQKET------LKSLLE-------QETENLRTEISKLNQKIQDNNENYQVGLAELRTLMT------IEKDQCISEL 1140
Cdd:PRK04863   946 QAQQTQRDAkqqafaLTEVVQrrahfsyEDAAEMLAKNSDLNEKLRQRLEQAEQERTRAREQLRqaqaqlAQYNQVLASL 1025
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1141 ISRHEEESNILKAELNkvtSLHNQAFEIEKNLKEQIIELQSKLDSELSAlERQKDEKITQQEEKYEAIIQNLEKDRQKLV 1220
Cdd:PRK04863  1026 KSSYDAKRQMLQELKQ---ELQDLGVPADSGAEERARARRDELHARLSA-NRSRRNQLEKQLTFCEAEMDNLTKKLRKLE 1101
                          330
                   ....*....|..
gi 1034662293 1221 SSQEQDREQLIQ 1232
Cdd:PRK04863  1102 RDYHEMREQVVN 1113
COG5022 COG5022
Myosin heavy chain [General function prediction only];
929-1375 5.93e-05

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 48.15  E-value: 5.93e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  929 EKDQKLLEMENIMHSQNCEIKELKQSREivledlkKLHVENDEKLQLLRAELQSLEQSH---LKELEDTLQVRHIQEFEK 1005
Cdd:COG5022    807 GSRKEYRSYLACIIKLQKTIKREKKLRE-------TEEVEFSLKAEVLIQKFGRSLKAKkrfSLLKKETIYLQSAQRVEL 879
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1006 VMTdhrvSLEELKKENQQIinqiqESHAEIIQEKEKQLQELKLKVSdlSDTRCKLEvelaLKEAETDEIKILLEESRAQQ 1085
Cdd:COG5022    880 AER----QLQELKIDVKSI-----SSLKLVNLELESEIIELKKSLS--SDLIENLE----FKTELIARLKKLLNNIDLEE 944
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1086 KETLKSLLEQETENLRTEISKLNQKIQD-NNENYQvglaelrtlMTIEKDQCISElisrhEEESNILKAELNKVTSLHNQ 1164
Cdd:COG5022    945 GPSIEYVKLPELNKLHEVESKLKETSEEyEDLLKK---------STILVREGNKA-----NSELKNFKKELAELSKQYGA 1010
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1165 AFEIEKNLKEQIIELQSKldselsalerQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQT 1244
Cdd:COG5022   1011 LQESTKQLKELPVEVAEL----------QSASKIISSESTELSILKPLQKLKGLLLLENNQLQARYKALKLRRENSLLDD 1080
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1245 ALKEFKLEREVVEKELLEKVKHLENQIAKSPA--IDSTRGDSSSLVAELQ-EKLQEEKAKFLEQLEEQEKRKNEEMQNVR 1321
Cdd:COG5022   1081 KQLYQLESTENLLKTINVKDLEVTNRNLVKPAnvLQFIVAQMIKLNLLQEiSKFLSQLVNTLEPVFQKLSVLQLELDGLF 1160
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1034662293 1322 TSLIAEQQTNFNT-VLTREKMRKENIINDLSDKLKSTmQQQERDKDLIESLSEDR 1375
Cdd:COG5022   1161 WEANLEALPSPPPfAALSEKRLYQSALYDEKSKLSSS-EVNDLKNELIALFSKIF 1214
PRK01156 PRK01156
chromosome segregation protein; Provisional
874-1374 6.05e-05

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 47.97  E-value: 6.05e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  874 YEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENI------MHSQNCE 947
Cdd:PRK01156   195 SNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMKNRYESEIKTAesdlsmELEKNNY 274
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  948 IKELKQ------------SREIVLE--DLKKLHVENDEKLQLLRAELQSLEQSHlKELEDtLQVRHIQ--EFEKVMTDHR 1011
Cdd:PRK01156   275 YKELEErhmkiindpvykNRNYINDyfKYKNDIENKKQILSNIDAEINKYHAII-KKLSV-LQKDYNDyiKKKSRYDDLN 352
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1012 VSLEELKKENQQIINQIQEshaeiIQEKEKQLQELKLKVSDLSDTRCKLeveLALKEAETDEIKILLEESRAQQKEtlks 1091
Cdd:PRK01156   353 NQILELEGYEMDYNSYLKS-----IESLKKKIEEYSKNIERMSAFISEI---LKIQEIDPDAIKKELNEINVKLQD---- 420
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1092 lleqetenLRTEISKLNQKIQDNNENyqvgLAELRTLMTIEKDQCISELISRH--EEESN-ILKAELNKVTSLHNQAFEI 1168
Cdd:PRK01156   421 --------ISSKVSSLNQRIRALREN----LDELSRNMEMLNGQSVCPVCGTTlgEEKSNhIINHYNEKKSRLEEKIREI 488
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1169 EKNLKEqIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKL--VSSQEQDREQLIQKLNCEKDEAIQTAL 1246
Cdd:PRK01156   489 EIEVKD-IDEKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKIneLKDKHDKYEEIKNRYKSLKLEDLDSKR 567
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1247 KEF--------KLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQE--KRKNEE 1316
Cdd:PRK01156   568 TSWlnalavisLIDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANNLNNKYNEIQenKILIEK 647
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034662293 1317 MQNV------RTSLIAEQQTNFNTVlTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSED 1374
Cdd:PRK01156   648 LRGKidnykkQIAEIDSIIPDLKEI-TSRINDIEDNLKKSRKALDDAKANRARLESTIEILRTR 710
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1007-1197 6.60e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.07  E-value: 6.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1007 MTDHRVSLEELKKENQQI--INQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQ 1084
Cdd:COG1579      2 MPEDLRALLDLQELDSELdrLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1085 QKETLKS----LLEQETENLRTEISKLNQKIQDNN---ENYQVGLAELRTLMTIEKDQcISELISRHEEESNILKAELNK 1157
Cdd:COG1579     82 LGNVRNNkeyeALQKEIESLKRRISDLEDEILELMeriEELEEELAELEAELAELEAE-LEEKKAELDEELAELEAELEE 160
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1034662293 1158 vtslhnqafeieknLKEQIIELQSKLDSELSAL-ERQKDEK 1197
Cdd:COG1579    161 --------------LEAEREELAAKIPPELLALyERIRKRK 187
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1093-1327 7.10e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 47.60  E-value: 7.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1093 LEQETENLRTEISKLnQKIQDNNENYQVGLAELRTLmtiekDQCISEL-ISRHEEESNILKAELNKVTSLHNQAFEIEKN 1171
Cdd:COG4913    240 AHEALEDAREQIELL-EPIRELAERYAAARERLAEL-----EYLRAALrLWFAQRRLELLEAELEELRAELARLEAELER 313
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1172 LKEQIIELQSKLDselsALERQKDEKITQQEEKYEAIIQNLEKDRQKlvssQEQDREQLiqklncekdeaiQTALKEFKL 1251
Cdd:COG4913    314 LEARLDALREELD----ELEAQIRGNGGDRLEQLEREIERLERELEE----RERRRARL------------EALLAALGL 373
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1252 EREVVEKELLEKVKHLENQIAKSPAI-DSTRGDSSSLVAELQEkLQEEKAKFLEQLEEQEKRKN---EEMQNVRTSLIAE 1327
Cdd:COG4913    374 PLPASAEEFAALRAEAAALLEALEEElEALEEALAEAEAALRD-LRRELRELEAEIASLERRKSnipARLLALRDALAEA 452
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
1015-1324 1.33e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 46.76  E-value: 1.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1015 EELKKENQQIINQIQESHaEIIQEKEKQLQELKLKVSDLSdtrckLEVELA---LKEAETDEIKILLE---ESRA--QQK 1086
Cdd:pfam12128  600 EELRERLDKAEEALQSAR-EKQAAAEEQLVQANGELEKAS-----REETFArtaLKNARLDLRRLFDEkqsEKDKknKAL 673
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1087 ETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTlmtiEKDQCISELISRHEEESNILKAELNKVtslhnqaf 1166
Cdd:pfam12128  674 AERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQKREART----EKQAYWQVVEGALDAQLALLKAAIAAR-------- 741
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1167 eiEKNLKEQIIELQSKLDSELSAL--ERQKDEKITQQEEKYEAIIQNLEKDRQKLVS---------SQEQDR-------- 1227
Cdd:pfam12128  742 --RSGAKAELKALETWYKRDLASLgvDPDVIAKLKREIRTLERKIERIAVRRQEVLRyfdwyqetwLQRRPRlatqlsni 819
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1228 EQLIQKLNCE---KDEAIQTALKEFKLEREVVEK------ELLEKVKHLENQIAKSpAIDSTRGDSSSLVAELQEKLQEE 1298
Cdd:pfam12128  820 ERAISELQQQlarLIADTKLRRAKLEMERKASEKqqvrlsENLRGLRCEMSKLATL-KEDANSEQAQGSIGERLAQLEDL 898
                          330       340
                   ....*....|....*....|....*.
gi 1034662293 1299 KAKfLEQLEEQEKRKNEEMQNVRTSL 1324
Cdd:pfam12128  899 KLK-RDYLSESVKKYVEHFKNVIADH 923
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
1022-1369 1.49e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 46.49  E-value: 1.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1022 QQIINQIQESHAEIIQEKEKQLQELKLKVSD--LSDTRCKLEVELALKEAETDEIKIlleESRAQQKETLKSLLEQETEN 1099
Cdd:COG5185    189 LKGISELKKAEPSGTVNSIKESETGNLGSEStlLEKAKEIINIEEALKGFQDPESEL---EDLAQTSDKLEKLVEQNTDL 265
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1100 LRTEISKLNQKIQDNNENYQVGLAELRTLmtiekdqciSELISRHEEESNILKAELNKVTSLhnQAFEIEKNLKEQIIEL 1179
Cdd:COG5185    266 RLEKLGENAESSKRLNENANNLIKQFENT---------KEKIAEYTKSIDIKKATESLEEQL--AAAEAEQELEESKRET 334
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1180 QSKLDselsalerQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQdrEQLIQKLNcekdeaiqtalkEFKLEREVVEKE 1259
Cdd:COG5185    335 ETGIQ--------NLTAEIEQGQESLTENLEAIKEEIENIVGEVEL--SKSSEELD------------SFKDTIESTKES 392
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1260 LLEKVKHLENQIAK-SPAIDSTRGDSSSLVAELQEKLQ------EEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNF 1332
Cdd:COG5185    393 LDEIPQNQRGYAQEiLATLEDTLKAADRQIEELQRQIEqatssnEEVSKLLNELISELNKVMREADEESQSRLEEAYDEI 472
                          330       340       350
                   ....*....|....*....|....*....|....*..
gi 1034662293 1333 NTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIE 1369
Cdd:COG5185    473 NRSVRSKKEDLNEELTQIESRVSTLKATLEKLRAKLE 509
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
956-1366 1.53e-04

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 46.35  E-value: 1.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  956 EIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQII------NQIQ 1029
Cdd:pfam10174  143 ELRIETQKQTLGARDESIKKLLEMLQSKGLPKKSGEEDWERTRRIAEAEMQLGHLEVLLDQKEKENIHLReelhrrNQLQ 222
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1030 ESHAE------IIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQK------ETLKSLL---E 1094
Cdd:pfam10174  223 PDPAKtkalqtVIEMKDTKISSLERNIRDLEDEVQMLKTNGLLHTEDREEEIKQMEVYKSHSKfmknkiDQLKQELskkE 302
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1095 QETENLRTEISKLNQKIQDNNENYQVglaelrtlmtiekdqcISELISRHEEESNILKAElnkVTSLHNQAFEIEKNLKE 1174
Cdd:pfam10174  303 SELLALQTKLETLTNQNSDCKQHIEV----------------LKESLTAKEQRAAILQTE---VDALRLRLEEKESFLNK 363
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1175 ---QIIELQ---SKLDSELSALERQ---KDEKITQQEEKYEAIIQNLeKDRQKLVSSQeQDREQLIQKLNCEKDEAIQT- 1244
Cdd:pfam10174  364 ktkQLQDLTeekSTLAGEIRDLKDMldvKERKINVLQKKIENLQEQL-RDKDKQLAGL-KERVKSLQTDSSNTDTALTTl 441
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1245 --ALKE-------FKLEREVVEKELLEKVKHL--ENQIAKSpAIDSTRGD---SSSLVAELQEKLQE------EKAKFLE 1304
Cdd:pfam10174  442 eeALSEkeriierLKEQREREDRERLEELESLkkENKDLKE-KVSALQPElteKESSLIDLKEHASSlassglKKDSKLK 520
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034662293 1305 QLEEQEKRKNEEMQNVRTSLIAEQQTNFNtvltrekmrkENIINDLSDKLKSTMQQQERDKD 1366
Cdd:pfam10174  521 SLEIAVEQKKEECSKLENQLKKAHNAEEA----------VRTNPEINDRIRLLEQEVARYKE 572
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
928-1263 1.83e-04

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 45.98  E-value: 1.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  928 NEKDQKLLEMENIMHSQNCEIKELKQS----REIVLEDLkklhvendEKLQLLRAELqsLEQSH-----LKELEDTLQ-- 996
Cdd:PRK04778   108 NEIESLLDLIEEDIEQILEELQELLESeeknREEVEQLK--------DLYRELRKSL--LANRFsfgpaLDELEKQLEnl 177
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  997 VRHIQEFEKVMT--DH---RVSLEELKKEN---QQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLevelalke 1068
Cdd:PRK04778   178 EEEFSQFVELTEsgDYveaREILDQLEEELaalEQIMEEIPELLKELQTELPDQLQELKAGYRELVEEGYHL-------- 249
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1069 aetDEIKIL--LEESRAQQKETLKSLLEQETENLRTEISKLNQKIqdnNENYQVGLAELRTLMTIEKDQ-CISELISRHE 1145
Cdd:PRK04778   250 ---DHLDIEkeIQDLKEQIDENLALLEELDLDEAEEKNEEIQERI---DQLYDILEREVKARKYVEKNSdTLPDFLEHAK 323
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1146 EESNILKAELNKVtslhNQAFEieknLKEQIIELQSKLDSELSALERQKD---EKITQQEEKYEAIIQNLEKDRQKLVSS 1222
Cdd:PRK04778   324 EQNKELKEEIDRV----KQSYT----LNESELESVRQLEKQLESLEKQYDeitERIAEQEIAYSELQEELEEILKQLEEI 395
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 1034662293 1223 QEQdREQLIQKL-NCEKDEAI-QTALKEFKLEREVVeKELLEK 1263
Cdd:PRK04778   396 EKE-QEKLSEMLqGLRKDELEaREKLERYRNKLHEI-KRYLEK 436
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
961-1348 1.90e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 46.58  E-value: 1.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  961 DLKKLHVENDEKLQLLRAELQsleqsHLKELEDTLQVRHIQEFEKVMTDHRVSLE---ELKKEN-QQIINQIQESHaEII 1036
Cdd:TIGR01612  480 DIKKDIDENSKQDNTVKLILM-----RMKDFKDIIDFMELYKPDEVPSKNIIGFDidqNIKAKLyKEIEAGLKESY-ELA 553
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1037 QEKEKQLQELKLKVSDLSDTRCKLEVE---LALKEAETDEIKILLEESRAQQKETLKSLLEQeTENLRTEISKlnQKIQD 1113
Cdd:TIGR01612  554 KNWKKLIHEIKKELEEENEDSIHLEKEikdLFDKYLEIDDEIIYINKLKLELKEKIKNISDK-NEYIKKAIDL--KKIIE 630
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1114 NNENYQVGLAELRTLMTIE----KDQCISELISrheEESNILKAELNKvtsLHNQAFEIEKNLKEQIIELQSKLDSELSA 1189
Cdd:TIGR01612  631 NNNAYIDELAKISPYQVPEhlknKDKIYSTIKS---ELSKIYEDDIDA---LYNELSSIVKENAIDNTEDKAKLDDLKSK 704
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1190 LERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEkdeaIQTALKEFKlerevvekellEKVKHLEN 1269
Cdd:TIGR01612  705 IDKEYDKIQNMETATVELHLSNIENKKNELLDIIVEIKKHIHGEINKD----LNKILEDFK-----------NKEKELSN 769
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034662293 1270 QIAKSPAIDSTRGDSSSLVAELQEKLQEEKAkfLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIIN 1348
Cdd:TIGR01612  770 KINDYAKEKDELNKYKSKISEIKNHYNDQIN--IDNIKDEDAKQNYDKSKEYIKTISIKEDEIFKIINEMKFMKDDFLN 846
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
947-1234 2.02e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 45.29  E-value: 2.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  947 EIKELKQSREIVLEDLKKLhvenDEKLQLLRAELQSLeqshlKELEDTLQVRHIQEFEKvmtdhrvsLEELKKENQQIIN 1026
Cdd:COG1340      9 SLEELEEKIEELREEIEEL----KEKRDELNEELKEL-----AEKRDELNAQVKELREE--------AQELREKRDELNE 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1027 QIQEsHAEIIQEKEKQLQELKLKVSDLSdtrcKLEVELALKEAETDEIKILLEESRAQQkETLKSLLEQETEnLRTEISK 1106
Cdd:COG1340     72 KVKE-LKEERDELNEKLNELREELDELR----KELAELNKAGGSIDKLRKEIERLEWRQ-QTEVLSPEEEKE-LVEKIKE 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1107 LNQKIQ------DNNENYQVGLAELRTLMTIEKDqcISELISRHEEESNILKAELnkvTSLHNQAFEIEKN---LKEQII 1177
Cdd:COG1340    145 LEKELEkakkalEKNEKLKELRAELKELRKEAEE--IHKKIKELAEEAQELHEEM---IELYKEADELRKEadeLHKEIV 219
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034662293 1178 ELQSKLDsELSALERQKDEKITQQEEKYEAIIQNLEKD-RQKLVSSQEQDREQLIQKL 1234
Cdd:COG1340    220 EAQEKAD-ELHEEIIELQKELRELRKELKKLRKKQRALkREKEKEELEEKAEEIFEKL 276
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1019-1315 2.07e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 45.66  E-value: 2.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1019 KENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSL--LEQE 1096
Cdd:COG4372      9 GKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELeeLNEQ 88
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1097 TENLRTEISKLNQKIQDNNENYQVGLAELRTLmtiekdqciselisrhEEESNILKAELNKVTSLHNQAFEIEKNLKEQI 1176
Cdd:COG4372     89 LQAAQAELAQAQEELESLQEEAEELQEELEEL----------------QKERQDLEQQRKQLEAQIAELQSEIAEREEEL 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1177 IELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVV 1256
Cdd:COG4372    153 KELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLG 232
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034662293 1257 EKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNE 1315
Cdd:COG4372    233 LALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEA 291
46 PHA02562
endonuclease subunit; Provisional
953-1215 2.40e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 45.78  E-value: 2.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  953 QSREIVlEDLKKLHVendeklqllRAELQSLEQSHLKELED-----TLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQ 1027
Cdd:PHA02562   151 ARRKLV-EDLLDISV---------LSEMDKLNKDKIRELNQqiqtlDMKIDHIQQQIKTYNKNIEEQRKKNGENIARKQN 220
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1028 IQESHAEIIQEKEKQLQELKLKVSDLsdTRCKLEVELALKEAETDEIKIlleesrAQQKETLKSLLEQETEN-------- 1099
Cdd:PHA02562   221 KYDELVEEAKTIKAEIEELTDELLNL--VMDIEDPSAALNKLNTAAAKI------KSKIEQFQKVIKMYEKGgvcptctq 292
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1100 -LRTEISKLnQKIQDNNENYQVGLAELRTlmTIEKDQCISELISRHEEESNILKAELNK----VTSLHNQAFEIEKnlke 1174
Cdd:PHA02562   293 qISEGPDRI-TKIKDKLKELQHSLEKLDT--AIDELEEIMDEFNEQSKKLLELKNKISTnkqsLITLVDKAKKVKA---- 365
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 1034662293 1175 QIIELQSKL---DSELSALERQKDEKITQQ----EEKYE-AIIQNLEKD 1215
Cdd:PHA02562   366 AIEELQAEFvdnAEELAKLQDELDKIVKTKselvKEKYHrGIVTDLLKD 414
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1161-1324 2.42e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.53  E-value: 2.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1161 LHNQAFEIEKNLKEQIIELQsKLDSELSALERQKdEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNcEKD- 1239
Cdd:COG1579     15 LDSELDRLEHRLKELPAELA-ELEDELAALEARL-EAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRN-NKEy 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1240 EAIQTALKEFKLEREVVEKELLEKVKHLEnqiAKSPAIDSTRGDSSSLVAELQEKlQEEKAKFLEQLEEQEKRKNEEMQN 1319
Cdd:COG1579     92 EALQKEIESLKRRISDLEDEILELMERIE---ELEEELAELEAELAELEAELEEK-KAELDEELAELEAELEELEAEREE 167

                   ....*
gi 1034662293 1320 VRTSL 1324
Cdd:COG1579    168 LAAKI 172
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
886-1059 2.44e-04

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 44.36  E-value: 2.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  886 EENENKIKKLKGelvcLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKL 965
Cdd:cd00176     33 ESVEALLKKHEA----LEAELAAHEERVEALNELGEQLIEEGHPDAEEIQERLEELNQRWEELRELAEERRQRLEEALDL 108
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  966 HVENDEKLQLL----RAELQSLEQSHLKELED-TLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKE 1040
Cdd:cd00176    109 QQFFRDADDLEqwleEKEAALASEDLGKDLESvEELLKKHKELEEELEAHEPRLKSLNELAEELLEEGHPDADEEIEEKL 188
                          170
                   ....*....|....*....
gi 1034662293 1041 KQLQELKLKVSDLSDTRCK 1059
Cdd:cd00176    189 EELNERWEELLELAEERQK 207
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
975-1333 2.45e-04

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 45.90  E-value: 2.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  975 LLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELK------------KENQQIINQIQESHAE---IIQEK 1039
Cdd:pfam09731   47 VLYALGEDPPLAPKPKTFRPLQPSVVSAVTGESKEPKEEKKQVKiprqsgvssevaEEEKEATKDAAEAKAQlpkSEQEK 126
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1040 EKQLQELKLKVSDLSDtrcklEVELALKEAETDEIKILLEE-------------SRAQQKETLKSLLEQETENLRTEISK 1106
Cdd:pfam09731  127 EKALEEVLKEAISKAE-----SATAVAKEAKDDAIQAVKAHtdslkeasdtaeiSREKATDSALQKAEALAEKLKEVINL 201
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1107 LNQ-----------KIQDNNENYQVGLAELRTLMTIEKDQ--CISELISRHEEESNILKAELNKVTSlhnqafEIEKNLK 1173
Cdd:pfam09731  202 AKQseeeaapplldAAPETPPKLPEHLDNVEEKVEKAQSLakLVDQYKELVASERIVFQQELVSIFP------DIIPVLK 275
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1174 EQIIELQSKLDS-------ELSALERQKDEKITQQEEKYEAIIQNLEKDrqklvssQEQDREQLIQKLNCEKDEAIQTAL 1246
Cdd:pfam09731  276 EDNLLSNDDLNSliahahrEIDQLSKKLAELKKREEKHIERALEKQKEE-------LDKLAEELSARLEEVRAADEAQLR 348
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1247 KEFKLEREVVEKELLEKvkhLENQIAKSPAIDSTRgdsssLVAELQEKLQEEKAKFLEQLEEqekrKNEEMQNVRTSLIA 1326
Cdd:pfam09731  349 LEFEREREEIRESYEEK---LRTELERQAEAHEEH-----LKDVLVEQEIELQREFLQDIKE----KVEEERAGRLLKLN 416

                   ....*..
gi 1034662293 1327 EQQTNFN 1333
Cdd:pfam09731  417 ELLANLK 423
HlpA COG2825
Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope ...
1182-1274 2.59e-04

Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442073 [Multi-domain]  Cd Length: 171  Bit Score: 43.29  E-value: 2.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1182 KLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELL 1261
Cdd:COG2825     43 AAQKKLEKEFKKRQAELQKLEKELQALQEKLQKEAATLSEEERQKKERELQKKQQELQRKQQEAQQDLQKRQQELLQPIL 122
                           90
                   ....*....|...
gi 1034662293 1262 EKVKHLENQIAKS 1274
Cdd:COG2825    123 EKIQKAIKEVAKE 135
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
959-1290 2.78e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 45.28  E-value: 2.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  959 LEDLKKLHVENDEKLQLLRAELQSlEQSHLKELEDTLQVRHiQEFEKVMTDHRVSLEELKKENQQIINQIQEshaeiIQE 1038
Cdd:COG4372     47 LEQLREELEQAREELEQLEEELEQ-ARSELEQLEEELEELN-EQLQAAQAELAQAQEELESLQEEAEELQEE-----LEE 119
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1039 KEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENY 1118
Cdd:COG4372    120 LQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKE 199
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1119 QVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKI 1198
Cdd:COG4372    200 EELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELE 279
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1199 TQQEEKYEAIIQNLEKDRQKLVSSQEqdreqlIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAID 1278
Cdd:COG4372    280 IAALELEALEEAALELKLLALLLNLA------ALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLVGLLDN 353
                          330
                   ....*....|..
gi 1034662293 1279 STRGDSSSLVAE 1290
Cdd:COG4372    354 DVLELLSKGAEA 365
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
959-1360 3.02e-04

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 45.23  E-value: 3.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  959 LEDLKKLHVEND--EKLQLLRAELQSLEQSHLKELEDtlqvrHIQEFEKVMTDHRVsleelkKENQQIINQIQEshaeII 1036
Cdd:pfam06160   31 LSKVKKLNLTGEtqEKFEEWRKKWDDIVTKSLPDIEE-----LLFEAEELNDKYRF------KKAKKALDEIEE----LL 95
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1037 QEKEKQLQELKLKVSDL--SDTRCKLEVElALKEaETDEIKILLEESRAQQKETLKSLLEQ--ETENLRTEISKLNQKiQ 1112
Cdd:pfam06160   96 DDIEEDIKQILEELDELleSEEKNREEVE-ELKD-KYRELRKTLLANRFSYGPAIDELEKQlaEIEEEFSQFEELTES-G 172
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1113 DNNENYQVgLAELRTlMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQ------AFEiEKNLKEQIIELQSKLDSE 1186
Cdd:pfam06160  173 DYLEAREV-LEKLEE-ETDALEELMEDIPPLYEELKTELPDQLEELKEGYREmeeegyALE-HLNVDKEIQQLEEQLEEN 249
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1187 LSALERQKDEKITQQEEKYEAIIQNL------EKDRQKLVSSQEQDREQLIQKLNCEKDEaIQTALKEFKLEREVVEKEL 1260
Cdd:pfam06160  250 LALLENLELDEAEEALEEIEERIDQLydllekEVDAKKYVEKNLPEIEDYLEHAEEQNKE-LKEELERVQQSYTLNENEL 328
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1261 lEKVKHLENQIAK--------SPAIDSTRGDSSSLVAELQ---------EKLQEEKAKFLEQLEEQEKRKNEEMQNVRTS 1323
Cdd:pfam06160  329 -ERVRGLEKQLEElekrydeiVERLEEKEVAYSELQEELEeileqleeiEEEQEEFKESLQSLRKDELEAREKLDEFKLE 407
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*..
gi 1034662293 1324 LIAeqqtnfntvlTREKMRKENI----------INDLSDKLKSTMQQ 1360
Cdd:pfam06160  408 LRE----------IKRLVEKSNLpglpesyldyFFDVSDEIEDLADE 444
PLN03229 PLN03229
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional
1038-1333 5.23e-04

acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional


Pssm-ID: 178768 [Multi-domain]  Cd Length: 762  Bit Score: 44.85  E-value: 5.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1038 EKEKQLQELKLKVSDLSDTRCKLeVELALKEAetdeIKILLEESRAQQKETLKSL-LEQETENLRTEISKLNQKIQDNNE 1116
Cdd:PLN03229   433 ELEGEVEKLKEQILKAKESSSKP-SELALNEM----IEKLKKEIDLEYTEAVIAMgLQERLENLREEFSKANSQDQLMHP 507
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1117 NYqvglaelrtlmtIEK-DQCISELISRHEEESNI--LKAELNKVTSLHNQAFEIEKNLKEQiiELQSKLDSELSALERQ 1193
Cdd:PLN03229   508 VL------------MEKiEKLKDEFNKRLSRAPNYlsLKYKLDMLNEFSRAKALSEKKSKAE--KLKAEINKKFKEVMDR 573
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1194 KDEKitqqeEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEK------------ELL 1261
Cdd:PLN03229   574 PEIK-----EKMEALKAEVASSGASSGDELDDDLKEKVEKMKKEIELELAGVLKSMGLEVIGVTKknkdtaeqtpppNLQ 648
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034662293 1262 EKVKHLENQIAK-------SPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNvrTSLIAEQQTNFN 1333
Cdd:PLN03229   649 EKIESLNEEINKkiervirSSDLKSKIELLKLEVAKASKTPDVTEKEKIEALEQQIKQKIAEALN--SSELKEKFEELE 725
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
877-1377 5.61e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 44.83  E-value: 5.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  877 KLDGLIKETEENENKIKKLKGELVCLEevlqnkdnefALVKHEKEAVICLQNEKDQKLLEMEnimhsqnceiKELKQSRE 956
Cdd:pfam12128  245 KLQQEFNTLESAELRLSHLHFGYKSDE----------TLIASRQEERQETSAELNQLLRTLD----------DQWKEKRD 304
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  957 IVLEDLKKLhvenDEKLQLLRAELQSLEQSHLKELEDTLQVRHiQEFEKvMTDHRVSLEELKKENQQIINQIQESHAEII 1036
Cdd:pfam12128  305 ELNGELSAA----DAAVAKDRSELEALEDQHGAFLDADIETAA-ADQEQ-LPSWQSELENLEERLKALTGKHQDVTAKYN 378
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1037 QEKEKQLQELKLKVSDLSDtrcklevelalkeaETDEIKilleESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNE 1116
Cdd:pfam12128  379 RRRSKIKEQNNRDIAGIKD--------------KLAKIR----EARDRQLAVAEDDLQALESELREQLEAGKLEFNEEEY 440
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1117 NYQVGLAELRTLmtIEKDQCISELISRHEeesnILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALeRQKDE 1196
Cdd:pfam12128  441 RLKSRLGELKLR--LNQATATPELLLQLE----NFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEAL-RQASR 513
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1197 KITQQEEKYEAIIQNLEKDRQKLV---SSQEQDREQLIQKLncekdeaIQTA-LKEFKLEREVVEKEL------------ 1260
Cdd:pfam12128  514 RLEERQSALDELELQLFPQAGTLLhflRKEAPDWEQSIGKV-------ISPElLHRTDLDPEVWDGSVggelnlygvkld 586
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1261 LEKVKH-----LENQI-AKSPAIDSTRGDSSSLVAELQEKLQEEKAKfLEQLEEQEKRKNEEMQNVRTSLI------AEQ 1328
Cdd:pfam12128  587 LKRIDVpewaaSEEELrERLDKAEEALQSAREKQAAAEEQLVQANGE-LEKASREETFARTALKNARLDLRrlfdekQSE 665
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034662293 1329 QTNFNTVLTREKMRKENIINDLS-------------------DKLKSTMQQQERDKDLIESLSEDRAR 1377
Cdd:pfam12128  666 KDKKNKALAERKDSANERLNSLEaqlkqldkkhqawleeqkeQKREARTEKQAYWQVVEGALDAQLAL 733
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1151-1363 7.77e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.60  E-value: 7.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1151 LKAELNKVTSLHNQAFEIEKNLKEQIIELQS---KLDSELSALERQKDEkITQQEEKYEAIIQNLEKDRQKLVSSQEQDR 1227
Cdd:COG4942     25 AEAELEQLQQEIAELEKELAALKKEEKALLKqlaALERRIAALARRIRA-LEQELAALEAELAELEKEIAELRAELEAQK 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1228 EQLIQKLN----CEKDEAIQTALKEFKLEREVVEKELLEKV-KHLENQIAkspAIDSTRGDSSSLVAELQEKlQEEKAKF 1302
Cdd:COG4942    104 EELAELLRalyrLGRQPPLALLLSPEDFLDAVRRLQYLKYLaPARREQAE---ELRADLAELAALRAELEAE-RAELEAL 179
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034662293 1303 LEQLEEQEKRKNEEMQNvRTSLIAEQQTNFNTVLTR--EKMRKENIINDLSDKLKSTMQQQER 1363
Cdd:COG4942    180 LAELEEERAALEALKAE-RQKLLARLEKELAELAAElaELQQEAEELEALIARLEAEAAAAAE 241
OmpH smart00935
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
1186-1273 8.88e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 214922 [Multi-domain]  Cd Length: 140  Bit Score: 41.03  E-value: 8.88e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  1186 ELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVK 1265
Cdd:smart00935   22 QLEKEFKKRQAELEKLEKELQKLKEKLQKDAATLSEAAREKKEKELQKKVQEFQRKQQKLQQDLQKRQQEELQKILDKIN 101

                    ....*...
gi 1034662293  1266 HLENQIAK 1273
Cdd:smart00935  102 KAIKEVAK 109
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
888-1127 1.07e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.75  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  888 NENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAvicLQNEKD--QKLLEMenimhsqnceikelkQSREIvleDLKKL 965
Cdd:COG4913    608 NRAKLAALEAELAELEEELAEAEERLEALEAELDA---LQERREalQRLAEY---------------SWDEI---DVASA 666
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  966 HvendEKLQLLRAELQSLEQSH--LKELEDTLQvrhiqefekvmtDHRVSLEELKKENQQIINQIQESHAEiIQEKEKQL 1043
Cdd:COG4913    667 E----REIAELEAELERLDASSddLAALEEQLE------------ELEAELEELEEELDELKGEIGRLEKE-LEQAEEEL 729
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1044 QELKLKVSDLSDTRCKLEVELALKEAETdeikILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLA 1123
Cdd:COG4913    730 DELQDRLEAAEDLARLELRALLEERFAA----ALGDAVERELRENLEERIDALRARLNRAEEELERAMRAFNREWPAETA 805

                   ....
gi 1034662293 1124 ELRT 1127
Cdd:COG4913    806 DLDA 809
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1174-1395 1.10e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.21  E-value: 1.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1174 EQIIELQSKLDsELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVssqeqDREQLIQKLNcEKDEAIQTALKEFKLER 1253
Cdd:COG4942     20 DAAAEAEAELE-QLQQEIAELEKELAALKKEEKALLKQLAALERRIA-----ALARRIRALE-QELAALEAELAELEKEI 92
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1254 EVVEKELLEKVKHLENQIAKspAIDSTRGDSSSLVAELQEKLQEEK-AKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTnf 1332
Cdd:COG4942     93 AELRAELEAQKEELAELLRA--LYRLGRQPPLALLLSPEDFLDAVRrLQYLKYLAPARREQAEELRADLAELAALRAE-- 168
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034662293 1333 ntvLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEekkkleeEVSKLRSS 1395
Cdd:COG4942    169 ---LEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAA-------ELAELQQE 221
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
824-1108 1.11e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 43.80  E-value: 1.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  824 TFVQKEQCDfsNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLS----LKNEYEGKLDGLIKETEENENKIKKLKGEL 899
Cdd:TIGR00618  571 SFSILTQCD--NRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQhallRKLQPEQDLQDVRLHLQQCSQELALKLTAL 648
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  900 VCLEEVL-QNKDNEFALVKHEKEAVIC---------LQNEKDQKLLEMENIMHSQ---NCEIKELKQSREIVLEDLKKLH 966
Cdd:TIGR00618  649 HALQLTLtQERVREHALSIRVLPKELLasrqlalqkMQSEKEQLTYWKEMLAQCQtllRELETHIEEYDREFNEIENASS 728
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  967 VE------NDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRvsLEELKKENQQIINQIQES-------HA 1033
Cdd:TIGR00618  729 SLgsdlaaREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAE--LSHLAAEIQFFNRLREEDthllktlEA 806
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034662293 1034 EIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLE--ESRAQQKETLKslleQETENLRTEISKLN 1108
Cdd:TIGR00618  807 EIGQEIPSDEDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLkyEECSKQLAQLT----QEQAKIIQLSDKLN 879
Golgin_A5 pfam09787
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ...
1013-1208 1.26e-03

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.


Pssm-ID: 462900 [Multi-domain]  Cd Length: 305  Bit Score: 42.82  E-value: 1.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1013 SLEELKKEnqqiINQIQESHAEIIQEKEKQLQELKlKVSDLSDTRCKLEVELALKEaetdeikilLEESRAQQKETLKSL 1092
Cdd:pfam09787    1 NLESAKQE----LADYKQKAARILQSKEKLIASLK-EGSGVEGLDSSTALTLELEE---------LRQERDLLREEIQKL 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1093 lEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKD--QCISELISRHEEESNILKAELNK-----VTSLHNQA 1165
Cdd:pfam09787   67 -RGQIQQLRTELQELEAQQQEEAESSREQLQELEEQLATERSarREAEAELERLQEELRYLEEELRRskatlQSRIKDRE 145
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1034662293 1166 FEIEKnLKEQII--ELQSKLDSELSALERQKDEKITQQEEKYEAI 1208
Cdd:pfam09787  146 AEIEK-LRNQLTskSQSSSSQSELENRLHQLTETLIQKQTMLEAL 189
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
969-1130 1.31e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.75  E-value: 1.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  969 NDEKLQLLRAELQSLEQSH---------LKELEDTLQVRH-----IQEFEKVMTDHRVSLEELKkENQQIINQIQESHAE 1034
Cdd:COG4913    608 NRAKLAALEAELAELEEELaeaeerleaLEAELDALQERRealqrLAEYSWDEIDVASAEREIA-ELEAELERLDASSDD 686
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1035 I------IQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQE-----TENLRTE 1103
Cdd:COG4913    687 LaaleeqLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERfaaalGDAVERE 766
                          170       180
                   ....*....|....*....|....*...
gi 1034662293 1104 ISK-LNQKIQDNNENYQVGLAELRTLMT 1130
Cdd:COG4913    767 LREnLEERIDALRARLNRAEEELERAMR 794
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
948-1322 1.44e-03

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 43.62  E-value: 1.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  948 IKELKQSREivlEDLKKLHVENDEKLQLLRAELQSLEQ--SHLKELED-TLQVRHIQEFEKVMTdhrVSLEELKKENQQI 1024
Cdd:PTZ00341   771 AKKLEQRSK---ANKEELANENNKLMNILKEYFGNNEQinSITYNFENiNLNEDNENGSKKILD---LNHKDQKEIFEEI 844
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1025 INQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKIL--LEESRAQQKETlKSLleqeTENLRT 1102
Cdd:PTZ00341   845 ISYIVDISLSDIENTAKNAAEQILSDEGLDEKKLKKRAESLKKLANAIEKYAGggKKDKKAKKKDA-KDL----SGNIAH 919
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1103 EISKLNQKIQDNNENYQVGLAElRTLMTIEKDqcISELISRHEEESNILKAELNKVTSLHNQAFE-IEKNLKEQIIElqs 1181
Cdd:PTZ00341   920 EINLINKELKNQNENVPEHLKE-HAEANIEED--AEENVEEDAEENVEENVEENVEENVEENVEEnVEENVEENVEE--- 993
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1182 kldselsALERQKDEKITQQEEkyEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLE--REVVEKE 1259
Cdd:PTZ00341   994 -------NVEENVEENIEENVE--ENVEENIEENVEEYDEENVEEVEENVEEYDEENVEEIEENAEENVEEniEENIEEY 1064
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034662293 1260 LLEKVKHLENQIAKSPAiDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRT 1322
Cdd:PTZ00341  1065 DEENVEEIEENIEENIE-ENVEENVEENVEEIEENVEENVEENAEENAEENAEENAEEYDDEN 1126
ATG17_like pfam04108
Autophagy protein ATG17-like domain; This domain is found in the autophagy-related proteins ...
404-538 1.44e-03

Autophagy protein ATG17-like domain; This domain is found in the autophagy-related proteins ATG17 and ATG11, conserved across eukaryotes. ATG17 forms a complex with ATG29 and ATG31, critical for both PAS (preautophagosomal structure) formation and autophagy. Together with ATG13, it is required for ATG1 kinase activation. ATG11 is a scaffold protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway during starvation and to recruit ATG proteins to the pre-autophagosome. It is also required for ATG1 kinase activation. In many eukaryotes, ATG11 (the orthologue in mammals is RB1-inducible coiled-coil protein 1 (RB1CC1) and in S. pombe is Taz1-interacting factor 1 (taf1)) is essential for bulk autophagy, except in S.cerevisiae. ATG17 and ATG11 are large similar proteins, both predicted to be almost entirely helical, containing conserved coiled-coil regions and lack obvious functional motifs.


Pssm-ID: 427715 [Multi-domain]  Cd Length: 360  Bit Score: 42.76  E-value: 1.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  404 KDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANNLHV------RLKWCCFVMLHADQDGEKLQALLRLVI 477
Cdd:pfam04108  214 NDARELDDVVPELQDRLDEMENNYERLQKLLEQKNSLIDELLSALQLiaeiqsRLPEYLAALKEFEERWEEEKETIEDYL 293
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034662293  478 ELLERVkiVEALSTVPQMYCLAVVEVVRRKMFIKHYREWAGALVKDGKRLYEAEKSKRESF 538
Cdd:pfam04108  294 SELEDL--REFYEGFPSAYGSLLLEVERRREWAEKMKKILRKLAEELDRLQEEERKRREKF 352
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
947-1128 1.50e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.37  E-value: 1.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  947 EIKELKQSREIVLEDLKKLHVENDE-KLQLLRAELQSLEQShLKELEDtlqvrHIQEFEKVMTDHRVSLEELKkenqqii 1025
Cdd:COG4913    263 RYAAARERLAELEYLRAALRLWFAQrRLELLEAELEELRAE-LARLEA-----ELERLEARLDALREELDELE------- 329
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1026 NQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELA-LKEAETDEIKILLEesRAQQKETLKSLLEQETENLRTEI 1104
Cdd:COG4913    330 AQIRGNGGDRLEQLEREIERLERELEERERRRARLEALLAaLGLPLPASAEEFAA--LRAEAAALLEALEEELEALEEAL 407
                          170       180
                   ....*....|....*....|....
gi 1034662293 1105 SKLNQKIQDNNENYQVGLAELRTL 1128
Cdd:COG4913    408 AEAEAALRDLRRELRELEAEIASL 431
Caldesmon pfam02029
Caldesmon;
828-1113 1.57e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 42.93  E-value: 1.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  828 KEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGliKETEENENKIKKLKGELVCLEEVLQ 907
Cdd:pfam02029   80 QEALERQKEFDPTIADEKESVAERKENNEEEENSSWEKEEKRDSRLGRYKEEE--TEIREKEYQENKWSTEVRQAEEEGE 157
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  908 NKDNEFALVKHEKEAVICLQNEKDQKLlemenimhsqnceIKELKQSREI-VLEDLKKLHVEndEKLQLLRAELQSLEQS 986
Cdd:pfam02029  158 EEEDKSEEAEEVPTENFAKEEVKDEKI-------------KKEKKVKYESkVFLDQKRGHPE--VKSQNGEEEVTKLKVT 222
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  987 HLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKvsdLSDTRCKLEVELAL 1066
Cdd:pfam02029  223 TKRRQGGLSQSQEREEEAEVFLEAEQKLEELRRRRQEKESEEFEKLRQKQQEAELELEELKKK---REERRKLLEEEEQR 299
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1034662293 1067 KEAETDEIKILLEESRAQQKEtlkslleqETENLRTEISKLNQKIQD 1113
Cdd:pfam02029  300 RKQEEAERKLREEEEKRRMKE--------EIERRRAEAAEKRQKLPE 338
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
857-1365 1.61e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 43.50  E-value: 1.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  857 ITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNefaLVKHEKEAVICLQNEKDQKLLE 936
Cdd:TIGR01612 2172 ITSAAKFSKDFFEFIEDISDSLNDDIDALQIKYNLNQTKKHMISILADATKDHNN---LIEKEKEATKIINNLTELFTID 2248
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  937 MEN----IMHSQNCEI----KELKQSREIVLEDLKKLHVEN-------DEKLQLLRAELQSLEQSHLKELEDTLQvrHIQ 1001
Cdd:TIGR01612 2249 FNNadadILHNNKIQIiyfnSELHKSIESIKKLYKKINAFKllnishiNEKYFDISKEFDNIIQLQKHKLTENLN--DLK 2326
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1002 EFEKVMTDH-RVSLEELKKENQQIINQIQESHAEIIQeKEKQLQELKlKVSDlsdtrcklevelalKEAE-----TDEIK 1075
Cdd:TIGR01612 2327 EIDQYISDKkNIFLHALNENTNFNFNALKEIYDDIIN-RENKADEIE-NINN--------------KENEnimqyIDTIT 2390
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1076 ILLEESraqqKETLKSLLEQETENlrteiSKLNQKIQDNNENYQVGLAE--LRTLMTIEKDQC-ISELISRHEEESNI-- 1150
Cdd:TIGR01612 2391 KLTEKI----QDILIFVTTYENDN-----NIIKQHIQDNDENDVSKIKDnlKKTIQSFQEILNkIDEIKAQFYGGNNInn 2461
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1151 ----LKAELNKVTSLHNQAFEIEKNLkeqiIELQSKLDSELSALERQKDEKITQQeekYEAIIQNLEKDRQKLVSSQEQD 1226
Cdd:TIGR01612 2462 iiitISQNANDVKNHFSKDLTIENEL----IQIQKRLEDIKNAAHEIRSEQITKY---TNAIHNHIEEQFKKIENNSNKD 2534
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1227 REQLIQKLncekDEAIQTaLKEFKLEREV-------VEKELLEKVKHLENQIAkspAIDSTRGDSSSLVAELQEKLQEEK 1299
Cdd:TIGR01612 2535 EVYKINEI----DNIIEK-IINYNKEPEVklhaiidNKNEFASIIPDIKNLIA---LIESEYGNNNNISYKVAIKHEEDA 2606
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034662293 1300 AKFLEQLEEQekrkneemQNVRTSLIAEQQTNFNTVltreKMRKENIINDlsDKLKSTMQQQERDK 1365
Cdd:TIGR01612 2607 NNIILDLNKS--------QNILNHLIHKNKKIIEDL----GNIKHGIHNN--NNLHTINKHEEISK 2658
PLN03229 PLN03229
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional
859-1115 1.70e-03

acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional


Pssm-ID: 178768 [Multi-domain]  Cd Length: 762  Bit Score: 42.92  E-value: 1.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  859 LKEKHQKELLSLKNEYEgKLDGLIKETEENENK---------IKKLKGEL----------VCLEEVLQNKDNEFALVKHE 919
Cdd:PLN03229   423 KREAVKTPVRELEGEVE-KLKEQILKAKESSSKpselalnemIEKLKKEIdleyteaviaMGLQERLENLREEFSKANSQ 501
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  920 --------KEAVICLQNEKDQKL------------LEMENIMHSQNCEIKELKQSREIVLEDLKKLHVEND-----EKLQ 974
Cdd:PLN03229   502 dqlmhpvlMEKIEKLKDEFNKRLsrapnylslkykLDMLNEFSRAKALSEKKSKAEKLKAEINKKFKEVMDrpeikEKME 581
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  975 LLRAELQSLEQSHLKELEDTL-----QVRHIQEFE--KVMTDHRVSLEELKKENQQIINQI-----QESHAEIIQEKEKQ 1042
Cdd:PLN03229   582 ALKAEVASSGASSGDELDDDLkekveKMKKEIELElaGVLKSMGLEVIGVTKKNKDTAEQTpppnlQEKIESLNEEINKK 661
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034662293 1043 LQELkLKVSDLSDTRCKLEVELA-----LKEAETDEIKILLEESRAQQKETLKSL-LEQETENLRTEISKLNQKIQDNN 1115
Cdd:PLN03229   662 IERV-IRSSDLKSKIELLKLEVAkasktPDVTEKEKIEALEQQIKQKIAEALNSSeLKEKFEELEAELAAARETAAESN 739
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
864-1229 1.82e-03

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 43.28  E-value: 1.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  864 QKELLSLKNEYEGKLDGL-----------IKETEENENKIKKLKGELVCLEEVlqnKDNEFALVKHEKEAVICLQNEKDQ 932
Cdd:PTZ00440  2257 KNKINNIKDKINDKEKELinvdssftlesIKTFNEIYDDIKSNIGDLYKLEDT---NNDELKKVKLYIENITHLLNRINT 2333
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  933 KLLEMENIMHSQNCEIKELKQSREIVlEDLKKLhvenDEKLQLLRAELQSLeqshLKELEDTLQVRHIQEFEKVMTDHRV 1012
Cdd:PTZ00440  2334 LINDLDNYQDENYGKDKNIELNNENN-SYIIKT----KEKINNLKEEFSKL----LKNIKRNNTLCNNNNIKDFISNIGK 2404
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1013 SLEELKKENQQIINQiqeshaeiiQEKEKQLQELKLKVSDL-SDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKS 1091
Cdd:PTZ00440  2405 SVETIKQRFSSNLPE---------KEKLHQIEENLNEIKNImNETKRISNVDAFTNKILQDIDNEKNKENNNMNAEKIDD 2475
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1092 LLEQETENLRTEISKLNQ------KIQDNNENYQVGLAELrTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQA 1165
Cdd:PTZ00440  2476 LIENVTSHNEKIKSELLIindalrRVKEKKDEMNKLFNSL-TENNNNNNNSAKNIVDNSTYIINELESHVSKLNELLSYI 2554
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034662293 1166 FEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRqkLVSSQEQDREQ 1229
Cdd:PTZ00440  2555 DNEIKELENEKLKLLEKAKIEESRKERERIESETQEDNTDEEQINRQQQER--LQKEEEQKAYS 2616
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
859-1240 2.16e-03

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 42.85  E-value: 2.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  859 LKEKHQKELLSLKNEyEGKLDGLIKETEENENKIKKLKGELvclEEVLQNKDNEfalvkHEKEAVICLQNEKDQKLLEmE 938
Cdd:PTZ00341   774 LEQRSKANKEELANE-NNKLMNILKEYFGNNEQINSITYNF---ENINLNEDNE-----NGSKKILDLNHKDQKEIFE-E 843
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  939 NIMHSQNCEIKELKQSREIVLEDLkkLHVEN-DEKLqlLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTD-------H 1010
Cdd:PTZ00341   844 IISYIVDISLSDIENTAKNAAEQI--LSDEGlDEKK--LKKRAESLKKLANAIEKYAGGGKKDKKAKKKDAKdlsgniaH 919
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1011 RVSL--EELKKENQQIINQIQE-SHAEIIQEKEKQLQE-LKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQK 1086
Cdd:PTZ00341   920 EINLinKELKNQNENVPEHLKEhAEANIEEDAEENVEEdAEENVEENVEENVEENVEENVEENVEENVEENVEENVEENV 999
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1087 EtlksllEQETENLRTEISklnQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAF 1166
Cdd:PTZ00341  1000 E------ENIEENVEENVE---ENIEENVEEYDEENVEEVEENVEEYDEENVEEIEENAEENVEENIEENIEEYDEENVE 1070
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034662293 1167 EIEKNLKEQIIE-LQSKLDSELSALERQKDEKITQQEEkyEAIIQNLEKDrqklvssQEQDREQLIQKLNCEKDE 1240
Cdd:PTZ00341  1071 EIEENIEENIEEnVEENVEENVEEIEENVEENVEENAE--ENAEENAEEN-------AEEYDDENPEEHNEEYDE 1136
Ubl_TBK1_like cd12219
ubiquitin-like (Ubl) domain found in non-canonical Inhibitor of kappa B kinases IKKepsilon and ...
3-76 2.61e-03

ubiquitin-like (Ubl) domain found in non-canonical Inhibitor of kappa B kinases IKKepsilon and TBK1, and similar proteins; IKKepsilon and TBK1 (TRAF family member-associated NF-kappaB activator-binding kinase 1) are non-canonical members of IKK family. They have been characterized as activators of nuclear factor-kappaB (NF-kappaB), but they are not essential for NF-kappaB activation. They play critical roles in antiviral response via phosphorylation and activation of transcription factors IRF3, IRF7, STAT1 and STAT3. They are also involved in the survival, tumorigenesis and development of various cancers. Both IKKepsilon and TBK1 contain an N-terminal protein kinase domain followed a ubiquitin-like (Ubl) domain. The Ubl domain acts as a protein-protein interaction domain, and has been implicated in regulating kinase activity, which modulates interactions in the interferon pathway.


Pssm-ID: 340518  Cd Length: 77  Bit Score: 38.37  E-value: 2.61e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034662293    3 LYVFLVNTGTTLTF---DTEltvqTVADLKHAIQSKYKIAIQHQVLVVNGGE-CMAADRRVCTYSAGTDTNPIFLFNK 76
Cdd:cd12219      4 IHVFSVSTCELLKIyldPTE----TLAEFQELIAEQTEIPAKNQLLLFEGQLlEEEVTLPVSDYPKTTEENPIILFNK 77
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
1149-1329 2.88e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 41.72  E-value: 2.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1149 NILKAELNKvtsLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKdEKITQQEEKYEAIIQnlEKDRQKlvsSQEQDRE 1228
Cdd:pfam15905  155 SSLSMELMK---LRNKLEAKMKEVMAKQEGMEGKLQVTQKNLEHSK-GKVAQLEEKLVSTEK--EKIEEK---SETEKLL 225
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1229 QLIQKLNCEKDEAIQTALKEFKLErevvekELLEKvKHLENQIAKSpAIDSTRGDSSSLVAELQEK---LQEEKAKFLEQ 1305
Cdd:pfam15905  226 EYITELSCVSEQVEKYKLDIAQLE------ELLKE-KNDEIESLKQ-SLEEKEQELSKQIKDLNEKcklLESEKEELLRE 297
                          170       180
                   ....*....|....*....|....
gi 1034662293 1306 LEEQEKRKNEEMQNVRTSLIAEQQ 1329
Cdd:pfam15905  298 YEEKEQTLNAELEELKEKLTLEEQ 321
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
950-1371 2.92e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 42.50  E-value: 2.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  950 ELKQSREIVLEDLKKLHVENdEKLQLLRAELQSLeQSHLKELEDTLqvRHIQEFEKVMTDHRVSLEELKKENQQIINQIQ 1029
Cdd:pfam10174   40 ELKKERALRKEEAARISVLK-EQYRVTQEENQHL-QLTIQALQDEL--RAQRDLNQLLQQDFTTSPVDGEDKFSTPELTE 115
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1030 ESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLE-------------------------ESRAQ 1084
Cdd:pfam10174  116 ENFRRLQSEHERQAKELFLLRKTLEEMELRIETQKQTLGARDESIKKLLEmlqskglpkksgeedwertrriaeaEMQLG 195
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1085 QKETLKSLLEQETENLRTEISKLNQKIQDNnenyqvglAELRTLMTI--EKDQCISEL---ISRHEEESNILKAELNKVT 1159
Cdd:pfam10174  196 HLEVLLDQKEKENIHLREELHRRNQLQPDP--------AKTKALQTVieMKDTKISSLernIRDLEDEVQMLKTNGLLHT 267
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1160 SLHNQ---AFEIEKN----LKEQIIELQSKL---DSELSALeRQKDEKITQQ-----------------EEKYEAIIQ-- 1210
Cdd:pfam10174  268 EDREEeikQMEVYKShskfMKNKIDQLKQELskkESELLAL-QTKLETLTNQnsdckqhievlkesltaKEQRAAILQte 346
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1211 ------NLEKDRQKLVSSQEQdreqlIQKLNCEKDeAIQTALKEFKLEREVVEKE----------LLEKVKHLENQIA-- 1272
Cdd:pfam10174  347 vdalrlRLEEKESFLNKKTKQ-----LQDLTEEKS-TLAGEIRDLKDMLDVKERKinvlqkkienLQEQLRDKDKQLAgl 420
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1273 ----KSPAIDSTRGDSSslVAELQEKLQeEKAKFLEQLEEQEKR----KNEEMQNVRTSL-IAEQQTNfntVLTREKMRK 1343
Cdd:pfam10174  421 kervKSLQTDSSNTDTA--LTTLEEALS-EKERIIERLKEQRERedreRLEELESLKKENkDLKEKVS---ALQPELTEK 494
                          490       500
                   ....*....|....*....|....*...
gi 1034662293 1344 ENIINDLSDKLKSTMQQQERDKDLIESL 1371
Cdd:pfam10174  495 ESSLIDLKEHASSLASSGLKKDSKLKSL 522
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
807-1373 2.97e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 42.73  E-value: 2.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  807 DSHFSIQTIKEDLCHFRTFVQKEQCDFSNsLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEgKLDGLIKETE 886
Cdd:TIGR01612 1650 DNLNSLQEFLESLKDQKKNIEDKKKELDE-LDSEIEKIEIDVDQHKKNYEIGIIEKIKEIAIANKEEIE-SIKELIEPTI 1727
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  887 EN---ENKIKKLKGelVCLEEVLQNKDNEFALVKHEkeaviclqnekdqkLLEMENIM-------HSQNCEIKELKQSRE 956
Cdd:TIGR01612 1728 ENlisSFNTNDLEG--IDPNEKLEEYNTEIGDIYEE--------------FIELYNIIagcletvSKEPITYDEIKNTRI 1791
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  957 IVL-EDLKKLHVENDEKLQLLRAELQSLEQ--SHLKELEDTLQVRHIQEFEKV---MTDHRVSLEELKKENQQ-----II 1025
Cdd:TIGR01612 1792 NAQnEFLKIIEIEKKSKSYLDDIEAKEFDRiiNHFKKKLDHVNDKFTKEYSKInegFDDISKSIENVKNSTDEnllfdIL 1871
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1026 NQIQESHAEIIQEK----EKQLQELKLKVSDLSDT---------------RCKLEVELALKEAETDEIKILLE-----ES 1081
Cdd:TIGR01612 1872 NKTKDAYAGIIGKKyysyKDEAEKIFINISKLANSiniqiqnnsgidlfdNINIAILSSLDSEKEDTLKFIPSpekepEI 1951
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1082 RAQQKETLKSLL------------EQETENLRTEISKLNQKIQDNNENYQVglaelrtlmtiekdqcISELISRHEEESN 1149
Cdd:TIGR01612 1952 YTKIRDSYDTLLdifkksqdlhkkEQDTLNIIFENQQLYEKIQASNELKDT----------------LSDLKYKKEKILN 2015
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1150 ILKAELNKVTSLhNQAFEIEKNLkEQIIEL--QSKLDSELSALERQK-----DEKITQQEEKYEAIIQNLEKdrqklVSS 1222
Cdd:TIGR01612 2016 DVKLLLHKFDEL-NKLSCDSQNY-DTILELskQDKIKEKIDNYEKEKekfgiDFDVKAMEEKFDNDIKDIEK-----FEN 2088
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1223 QEQDREQLIQKLNCEKDEAIQT--ALKE----FKLEREVVEKELLEKvKHLENQIAKspaidsTRGDS-----SSLVAEL 1291
Cdd:TIGR01612 2089 NYKHSEKDNHDFSEEKDNIIQSkkKLKElteaFNTEIKIIEDKIIEK-NDLIDKLIE------MRKECllfsyATLVETL 2161
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1292 QEKLQEEkAKFLEQLEEQEKRKNEEMQNVRTSL---IAEQQTNFNTVLTREKMrkENIINDLSDKLKSTMQQQERDKDLI 1368
Cdd:TIGR01612 2162 KSKVINH-SEFITSAAKFSKDFFEFIEDISDSLnddIDALQIKYNLNQTKKHM--ISILADATKDHNNLIEKEKEATKII 2238

                   ....*
gi 1034662293 1369 ESLSE 1373
Cdd:TIGR01612 2239 NNLTE 2243
PRK12704 PRK12704
phosphodiesterase; Provisional
1137-1273 3.14e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.07  E-value: 3.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1137 ISELISRHEEESNILKAELNKvtslhnqafeieknLKEQIIELQSKLDSELSALErQKDEKITQQEEKYEAIIQNLEKDR 1216
Cdd:PRK12704    66 IHKLRNEFEKELRERRNELQK--------------LEKRLLQKEENLDRKLELLE-KREEELEKKEKELEQKQQELEKKE 130
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034662293 1217 QKLVSSQEQDREQLIQKLNCEKDEA----IQTALKEFKLEREVVEKELLEKVKHLENQIAK 1273
Cdd:PRK12704   131 EELEELIEEQLQELERISGLTAEEAkeilLEKVEEEARHEAAVLIKEIEEEAKEEADKKAK 191
PRK12704 PRK12704
phosphodiesterase; Provisional
1212-1355 3.22e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.07  E-value: 3.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1212 LEKDRQKLVSSQEQDREQLIQ----KLNCEKDEAIQTALKEFKLEREVVEKELLEK---VKHLENQIA-KSPAIDstrgD 1283
Cdd:PRK12704    25 RKKIAEAKIKEAEEEAKRILEeakkEAEAIKKEALLEAKEEIHKLRNEFEKELRERrneLQKLEKRLLqKEENLD----R 100
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034662293 1284 SSSLVAELQEKLQEEKAKfLEQLEEQEKRKNEEMQNvrtsLIAEQQTNFNTV--LTREKMRKEnIINDLSDKLK 1355
Cdd:PRK12704   101 KLELLEKREEELEKKEKE-LEQKQQELEKKEEELEE----LIEEQLQELERIsgLTAEEAKEI-LLEKVEEEAR 168
mukB PRK04863
chromosome partition protein MukB;
970-1329 3.26e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 42.25  E-value: 3.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  970 DEKLQLLRAELQSLEQSHLKELEdtlQVRHIQEFEKV---MTDHRVSLEELKKENQQIINQIQESHAEIIQ---EKEKQL 1043
Cdd:PRK04863   512 AEQLQQLRMRLSELEQRLRQQQR---AERLLAEFCKRlgkNLDDEDELEQLQEELEARLESLSESVSEARErrmALRQQL 588
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1044 QELKLKVSDLSDTR----------CKLE----VELALKEAETDEIKILLEESRAQQKEtlKSLLEQETENLRTEISKLNQ 1109
Cdd:PRK04863   589 EQLQARIQRLAARApawlaaqdalARLReqsgEEFEDSQDVTEYMQQLLERERELTVE--RDELAARKQALDEEIERLSQ 666
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1110 KIQDNNENYQ--------VGLAELRTLMTIEKDQCISELI--SRHEeesnILKAELNKVTslhnQAFEIEKNLKEQI--I 1177
Cdd:PRK04863   667 PGGSEDPRLNalaerfggVLLSEIYDDVSLEDAPYFSALYgpARHA----IVVPDLSDAA----EQLAGLEDCPEDLylI 738
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1178 E--LQSKLDSELSALERQKDekITQQeekyeaiiqnlEKDRQKLVSS-------QEQDREQLIQKLNCEKDEAIQtalKE 1248
Cdd:PRK04863   739 EgdPDSFDDSVFSVEELEKA--VVVK-----------IADRQWRYSRfpevplfGRAAREKRIEQLRAEREELAE---RY 802
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1249 FKLEREVVEKELLekVKHLENQIAKSPAIdSTRGDSSSLVAELQEKLQEEKAKfLEQLEEQEKRKNEEMQNVRTSLIAEQ 1328
Cdd:PRK04863   803 ATLSFDVQKLQRL--HQAFSRFIGSHLAV-AFEADPEAELRQLNRRRVELERA-LADHESQEQQQRSQLEQAKEGLSALN 878

                   .
gi 1034662293 1329 Q 1329
Cdd:PRK04863   879 R 879
CCDC14 pfam15254
Coiled-coil domain-containing protein 14; This protein family, Coiled-coil domain-containing ...
1043-1306 3.35e-03

Coiled-coil domain-containing protein 14; This protein family, Coiled-coil domain-containing protein 14 (CCDC14) is a domain of unknown function. This family of proteins is found in eukaryotes. Proteins in this family are typically between 301 and 912 amino acids in length.


Pssm-ID: 464594  Cd Length: 857  Bit Score: 42.09  E-value: 3.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1043 LQELKLKVSDLSDT---RCKLEVE--LALKEAETDEIKILLEESRAQQKetlkslLEQETENLRTEISKLNQKIQDNNen 1117
Cdd:pfam15254  343 LGELKALVADQEDSevlRLITEVEacVSLLPAVSGNTNIQAEIALALQP------LRSENAQLRRQLRILNQQLREQE-- 414
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1118 yqvglaelRTLMTIEKDQCISELISrheeesniLKAeLNKvtSLHNQAFEIEKNLKEqiieLQSKLDSELSALERQKDEK 1197
Cdd:pfam15254  415 --------KTEKTSGSGDCNLELFS--------LQS-LNM--SLQNQLQESLKSQEL----LQSKNEELLKVIENQKEEN 471
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1198 itqqeEKYEAIIQnlEKDRQKLVSSQEQDREqlIQKLNCEKDEAIqTALKEFKLEREVVEKellekvkhlENQIAkspAI 1277
Cdd:pfam15254  472 -----KKLTKIFK--EKEQTLLENKQQFDIE--TTRVKIELEEAL-VNMKSFQFKLEAAEK---------ENQIL---GI 529
                          250       260       270
                   ....*....|....*....|....*....|
gi 1034662293 1278 DSTRGDSS-SLVAELQEKLQEEKAKFLEQL 1306
Cdd:pfam15254  530 TLRQRDAEvTRLRELTRTLQGSMAKLLSDL 559
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
1009-1357 3.39e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 42.34  E-value: 3.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1009 DHRVSLEELKKENQQIINQIQESHAE-----IIQEKEKQLQE---------LKLKVS------DLSDTRCKLEVElalke 1068
Cdd:PTZ00108   901 DYKEFLESETLKEKDVIVDYRDYSTAntvhfTVKLNDGVLEQweeegiekvFKLKSTisttnmVLFDENGKIKKY----- 975
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1069 aeTDEIKILLE------ESRAQQKETLKSLLEQETENLRTEISKL----NQKIQDNNENYQVGLAELRTLMTIEKDQcis 1138
Cdd:PTZ00108   976 --SDALDILKEfylvrlDLYKKRKEYLLGKLERELARLSNKVRFIkhviNGELVITNAKKKDLVKELKKLGYVRFKD--- 1050
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1139 elISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIiELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEK---- 1214
Cdd:PTZ00108  1051 --IIKKKSEKITAEEEEGAEEDDEADDEDDEEELGAAV-SYDYLLSMPIWSLTKEKVEKLNAELEKKEKELEKLKNttpk 1127
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1215 -----DRQKLVS---SQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSS 1286
Cdd:PTZ00108  1128 dmwleDLDKFEEaleEQEEVEEKEIAKEQRLKSKTKGKASKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKR 1207
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034662293 1287 LVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKST 1357
Cdd:PTZ00108  1208 KLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRV 1278
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
948-1307 3.71e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.43  E-value: 3.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  948 IKELKQSREIVLEDLKKLHvendEKLQLLRAELQSLEQShLKELEDTLQVRHIQefekvmtdhrvsLEELKKENQQIINQ 1027
Cdd:COG4372     26 IAALSEQLRKALFELDKLQ----EELEQLREELEQAREE-LEQLEEELEQARSE------------LEQLEEELEELNEQ 88
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1028 IQESHAEIIQEKEkQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETlksllEQETENLRTEISKL 1107
Cdd:COG4372     89 LQAAQAELAQAQE-ELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAER-----EEELKELEEQLESL 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1108 NQKIQDNNENYQvglaelrtlmtiekdqciSELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSEL 1187
Cdd:COG4372    163 QEELAALEQELQ------------------ALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAK 224
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1188 SALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHL 1267
Cdd:COG4372    225 DSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNL 304
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 1034662293 1268 ENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLE 1307
Cdd:COG4372    305 AALSLIGALEDALLAALLELAKKLELALAILLAELADLLQ 344
DUF4659 pfam15558
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ...
929-1270 4.33e-03

Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.


Pssm-ID: 464768 [Multi-domain]  Cd Length: 374  Bit Score: 41.18  E-value: 4.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  929 EKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLhvENDEKLQLLRAELQSLEQShlkeledtlQVRHIQEFEKVMT 1008
Cdd:pfam15558    4 ERDRKIAALMLARHKEEQRMRELQQQAALAWEELRRR--DQKRQETLERERRLLLQQS---------QEQWQAEKEQRKA 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1009 dhRVSLEELKKENQQIINQIQ--ESHAEIIQEKEKQLQElKLKVSDLSDTRCKLEVELALKEAETdeikiLLEESRAQQK 1086
Cdd:pfam15558   73 --RLGREERRRADRREKQVIEkeSRWREQAEDQENQRQE-KLERARQEAEQRKQCQEQRLKEKEE-----ELQALREQNS 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1087 ETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMtiEKDQCISELISRHEEESNILKAELNKVTSLHNQAF 1166
Cdd:pfam15558  145 LQLQERLEEACHKRQLKEREEQKKVQENNLSELLNHQARKVLV--DCQAKAEELLRRLSLEQSLQRSQENYEQLVEERHR 222
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1167 EI-EKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKyeaiiQNLEKDRQkLVSSQEQDREQLIQKLNcekdeaiqta 1245
Cdd:pfam15558  223 ELrEKAQKEEEQFQRAKWRAEEKEEERQEHKEALAELAD-----RKIQQARQ-VAHKTVQDKAQRARELN---------- 286
                          330       340
                   ....*....|....*....|....*
gi 1034662293 1246 lkefkLEREVVEKELLEKVKHLENQ 1270
Cdd:pfam15558  287 -----LEREKNHHILKLKVEKEEKC 306
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
958-1121 4.46e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 41.74  E-value: 4.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  958 VLEDLKKLHVENDEKLQLLRAELQSLEqshlKELEDtlQVRHIQEFEKvmtdhrvSLEELKKENQQIINQIQESHAEIIQ 1037
Cdd:PRK00409   503 IIEEAKKLIGEDKEKLNELIASLEELE----RELEQ--KAEEAEALLK-------EAEKLKEELEEKKEKLQEEEDKLLE 569
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1038 EKEKQLQElklkvsdlsdtrcklevelALKEAeTDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQ-------K 1110
Cdd:PRK00409   570 EAEKEAQQ-------------------AIKEA-KKEADEIIKELRQLQKGGYASVKAHELIEARKRLNKANEkkekkkkK 629
                          170
                   ....*....|.
gi 1034662293 1111 IQDNNENYQVG 1121
Cdd:PRK00409   630 QKEKQEELKVG 640
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
860-1189 4.97e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 41.42  E-value: 4.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  860 KEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMEN 939
Cdd:pfam07888   57 REKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELEE 136
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  940 IMHSqnceIKELKQSREIVLEDLK--------KLHVENDEKLQL-------------LRAELQSLEQSHLKELEDTLQvr 998
Cdd:pfam07888  137 DIKT----LTQRVLERETELERMKerakkagaQRKEEEAERKQLqaklqqteeelrsLSKEFQELRNSLAQRDTQVLQ-- 210
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  999 hIQEFEKVMTDHRVSLEELKKENQQIINQIQeSHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILL 1078
Cdd:pfam07888  211 -LQDTITTLTQKLTTAHRKEAENEALLEELR-SLQERLNASERKVEGLGEELSSMAAQRDRTQAELHQARLQAAQLTLQL 288
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1079 EESRAQQKETlKSLLEQETENL-------RTEISKLNQKIQDNNENYQVGLAE---LRTLMTIEKDqCISELISRHEEES 1148
Cdd:pfam07888  289 ADASLALREG-RARWAQERETLqqsaeadKDRIEKLSAELQRLEERLQEERMErekLEVELGREKD-CNRVQLSESRREL 366
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 1034662293 1149 NILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSA 1189
Cdd:pfam07888  367 QELKASLRVAQKEKEQLQAEKQELLEYIRQLEQRLETVADA 407
AAA_13 pfam13166
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
1019-1191 5.32e-03

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. This family includes the PrrC protein that is thought to be the active component of the anticodon nuclease.


Pssm-ID: 463796 [Multi-domain]  Cd Length: 712  Bit Score: 41.58  E-value: 5.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1019 KENQQIINQIQESHAEIIQEKEKQLQELKlKVSDLSDTR--CKLEVELALKEAET-----DEIKILLEESRAQ--QKETL 1089
Cdd:pfam13166  279 DEFTEFQNRLQKLIEKVESAISSLLAQLP-AVSDLASLLsaFELDVEDIESEAEVlnsqlDGLRRALEAKRKDpfKSIEL 357
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1090 KSLLEqETENLRTEISKLNQKIQDNNE---NYQVGLAELRTLmtIEKDQcISELISRHEEESNILKAELNKVTSLHNQAF 1166
Cdd:pfam13166  358 DSVDA-KIESINDLVASINELIAKHNEitdNFEEEKNKAKKK--LRLHL-VEEFKSEIDEYKDKYAGLEKAINSLEKEIK 433
                          170       180
                   ....*....|....*....|....*...
gi 1034662293 1167 EIE---KNLKEQIIELQSKLDSELSALE 1191
Cdd:pfam13166  434 NLEaeiKKLREEIKELEAQLRDHKPGAD 461
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
848-1367 5.44e-03

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 41.74  E-value: 5.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  848 IEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKgelvcleEVLQNKDNEFALVKHEKEAviclq 927
Cdd:PTZ00440   791 NKENKISNDINILKENKKNNQDLLNSYNILIQKLEAHTEKNDEELKQLL-------QKFPTEDENLNLKELEKEF----- 858
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  928 NEKDQKLlemENIMHSQNCEIKElkqsreivLEDLKKLHVENDEKlqllRAELQSLEqsHLKELEDTLQVRHIQEFEKVM 1007
Cdd:PTZ00440   859 NENNQIV---DNIIKDIENMNKN--------INIIKTLNIAINRS----NSNKQLVE--HLLNNKIDLKNKLEQHMKIIN 921
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1008 TDHRVSLEE-------LKKENQQIINQIQESHaeiiqekekqLQELKLKVSDLsdtrckLEVELALKEAETDEIKILLEE 1080
Cdd:PTZ00440   922 TDNIIQKNEklnllnnLNKEKEKIEKQLSDTK----------INNLKMQIEKT------LEYYDKSKENINGNDGTHLEK 985
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1081 SRAQQKETlkSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTS 1160
Cdd:PTZ00440   986 LDKEKDEW--EHFKSEIDKLNVNYNILNKKIDDLIKKQHDDIIELIDKLIKEKGKEIEEKVDQYISLLEKMKTKLSSFHF 1063
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1161 lhNQAFEIEKN--LKEQIIELQSKLDSELSALErQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLncek 1238
Cdd:PTZ00440  1064 --NIDIKKYKNpkIKEEIKLLEEKVEALLKKID-ENKNKLIEIKNKSHEHVVNADKEKNKQTEHYNKKKKSLEKIY---- 1136
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1239 dEAIQTALKEfkLEREVVEKELLEKVKHLENQIAKspaidstrgdssSLVAELQEKLQEEKAKFLEQLEEQEKRKnEEMQ 1318
Cdd:PTZ00440  1137 -KQMEKTLKE--LENMNLEDITLNEVNEIEIEYER------------ILIDHIVEQINNEAKKSKTIMEEIESYK-KDID 1200
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034662293 1319 NVRTSLIAEQQ---TNFN-TVLTREKMRKENIINDLSDKLKSTMQQQERDKDL 1367
Cdd:PTZ00440  1201 QVKKNMSKERNdhlTTFEyNAYYDKATASYENIEELTTEAKGLKGEANRSTNV 1253
PRK12704 PRK12704
phosphodiesterase; Provisional
1014-1209 5.47e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.30  E-value: 5.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1014 LEELKKENQQIInqiQESHAEIIQEKEKQLQELKLKVSDLsdtrcKLEVELALKEAEtDEIKILleESRAQQKEtlkSLL 1093
Cdd:PRK12704    33 IKEAEEEAKRIL---EEAKKEAEAIKKEALLEAKEEIHKL-----RNEFEKELRERR-NELQKL--EKRLLQKE---ENL 98
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1094 EQETENLRTEISKLNQKIQDNNENYQvglaelrtlmTIEKDQciSELISRHEEEsnilKAELNKVTSLhnQAFEIeknlK 1173
Cdd:PRK12704    99 DRKLELLEKREEELEKKEKELEQKQQ----------ELEKKE--EELEELIEEQ----LQELERISGL--TAEEA----K 156
                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1034662293 1174 EQIIE-LQSKLDSELSALERQKDEKITQQEEKY-EAII 1209
Cdd:PRK12704   157 EILLEkVEEEARHEAAVLIKEIEEEAKEEADKKaKEIL 194
mukB PRK04863
chromosome partition protein MukB;
949-1271 6.03e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 41.48  E-value: 6.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  949 KELKQSREIvLEDLKKLHVENDEKLQLLRAELQSLEQSHlKELEDTLQ-----VRHIQEFEKvmtdHRVSLEEL--KKEN 1021
Cdd:PRK04863   293 RELYTSRRQ-LAAEQYRLVEMARELAELNEAESDLEQDY-QAASDHLNlvqtaLRQQEKIER----YQADLEELeeRLEE 366
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1022 QqiiNQIQESHAEIIQEKEKQLQELKLKV----SDLSDTRCKLEVE-----------LALKEAET---------DEIKIL 1077
Cdd:PRK04863   367 Q---NEVVEEADEQQEENEARAEAAEEEVdelkSQLADYQQALDVQqtraiqyqqavQALERAKQlcglpdltaDNAEDW 443
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1078 LEESRAQQKETLKSLLEQET-----ENLRTEISKLNQKIQ------DNNENYQVGLAELRTLMT--IEKDQC------IS 1138
Cdd:PRK04863   444 LEEFQAKEQEATEELLSLEQklsvaQAAHSQFEQAYQLVRkiagevSRSEAWDVARELLRRLREqrHLAEQLqqlrmrLS 523
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1139 ELISRHEEESNI--LKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSAL-ERQKDEKitQQEEKYEAIIQNLEKD 1215
Cdd:PRK04863   524 ELEQRLRQQQRAerLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSEArERRMALR--QQLEQLQARIQRLAAR 601
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034662293 1216 RQKLVSSQ---EQDREQLIQKL--NCEKDEAIQTALKEFKlEREVVEKELLEKVKHLENQI 1271
Cdd:PRK04863   602 APAWLAAQdalARLREQSGEEFedSQDVTEYMQQLLERER-ELTVERDELAARKQALDEEI 661
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
953-1262 6.15e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 41.16  E-value: 6.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  953 QSREIVLEDLKKLHVENDEKLQLLRaelqslEQSHLKELEDTLQVRHIQEfEKVMTdhrVSLE-ELKKENQQIINQIqes 1031
Cdd:COG3206     91 KSRPVLERVVDKLNLDEDPLGEEAS------REAAIERLRKNLTVEPVKG-SNVIE---ISYTsPDPELAAAVANAL--- 157
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1032 hAEIIQEkekqlQELKLKVSDLSDTRCKLEVELA-----LKEAEtDEIKILLEESRAQQKETLKSLLEQETENLRTEISK 1106
Cdd:COG3206    158 -AEAYLE-----QNLELRREEARKALEFLEEQLPelrkeLEEAE-AALEEFRQKNGLVDLSEEAKLLLQQLSELESQLAE 230
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1107 LNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNkvtslhnqafEIEKNLKE---QIIELQSKL 1183
Cdd:COG3206    231 ARAELAEAEARLAALRAQLGSGPDALPELLQSPVIQQLRAQLAELEAELA----------ELSARYTPnhpDVIALRAQI 300
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1184 DselsALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQlIQKLNcekdeAIQTALKEfkLEREV-VEKELLE 1262
Cdd:COG3206    301 A----ALRAQLQQEAQRILASLEAELEALQAREASLQAQLAQLEAR-LAELP-----ELEAELRR--LEREVeVARELYE 368
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
854-1104 6.46e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 40.66  E-value: 6.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  854 SLEITLKEKHqKELLSLKNEYEGKLDGLIKE----TEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNE 929
Cdd:COG1340      8 SSLEELEEKI-EELREEIEELKEKRDELNEElkelAEKRDELNAQVKELREEAQELREKRDELNEKVKELKEERDELNEK 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  930 KDQKLLEMENImHSQNCEIKELKQSREIVLEDLKKL-----------HVEND--EKLQLLRAELQSLEQSHLKEledtlq 996
Cdd:COG1340     87 LNELREELDEL-RKELAELNKAGGSIDKLRKEIERLewrqqtevlspEEEKElvEKIKELEKELEKAKKALEKN------ 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  997 vRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKE------KQLQELKLKVSDLSDTRCKLEVELALKEAE 1070
Cdd:COG1340    160 -EKLKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKeadelrKEADELHKEIVEAQEKADELHEEIIELQKE 238
                          250       260       270
                   ....*....|....*....|....*....|....
gi 1034662293 1071 TDEIKILLEESRAQQKETLKSLLEQETENLRTEI 1104
Cdd:COG1340    239 LRELRKELKKLRKKQRALKREKEKEELEEKAEEI 272
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
887-1394 6.60e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 41.58  E-value: 6.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  887 ENENKIKKLKGELVCLEEVLQNKDNEFALVKHEkeaviCLQNEkdqklLEMENIMHSQNC---------EIKELKQSREI 957
Cdd:TIGR01612  331 ESEGEQGHIINKLIFLEKEFEDTIHKSDIYKDE-----CLSNH-----LFMEDYLKDDKIspyyyefleEIKKIAKQRAI 400
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  958 VLEDLKKLhvendEKLQLLRAELQSLEQSHLKELEdtlqvrhiqefekvmtdhRVSLEELKKENQQIINqiqeshaEIIQ 1037
Cdd:TIGR01612  401 FFYNAKKL-----KHLEILYKHQEDILNNFHKTIE------------------RLIFEKPDPNNNNIFK-------DDFD 450
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1038 EKEKQLQELKLKvsdLSDTRCkleVELALKEAETDEIKILLEESrAQQKETLKSLLEQETEnlrteisklNQKIQDNNEN 1117
Cdd:TIGR01612  451 EFNKPIPKSKLK---ALEKRF---FEIFEEEWGSYDIKKDIDEN-SKQDNTVKLILMRMKD---------FKDIIDFMEL 514
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1118 YQVGLAELRTLMTIEKDQCISELIsrHEEESNILKAELNKVTSLHNQAFEIEKNLKEQ---IIELQSKLDSELSALERQK 1194
Cdd:TIGR01612  515 YKPDEVPSKNIIGFDIDQNIKAKL--YKEIEAGLKESYELAKNWKKLIHEIKKELEEEnedSIHLEKEIKDLFDKYLEID 592
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1195 DEKITQQEEKYEAiiqnleKDRQKLVSSQEQ------DREQLIQKLNCEKDEAIQTAlkEFKLEREVVEKE-LLEKVKHL 1267
Cdd:TIGR01612  593 DEIIYINKLKLEL------KEKIKNISDKNEyikkaiDLKKIIENNNAYIDELAKIS--PYQVPEHLKNKDkIYSTIKSE 664
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1268 ENQIAKSPaIDSTRGDSSSLVAELQEKLQEEKAKfLEQLEEQEKRKNEEMQNVRTSLIAEQ----QTNFNTVLTREKMRK 1343
Cdd:TIGR01612  665 LSKIYEDD-IDALYNELSSIVKENAIDNTEDKAK-LDDLKSKIDKEYDKIQNMETATVELHlsniENKKNELLDIIVEIK 742
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1034662293 1344 ENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRS 1394
Cdd:TIGR01612  743 KHIHGEINKDLNKILEDFKNKEKELSNKINDYAKEKDELNKYKSKISEIKN 793
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
937-1470 6.98e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 41.25  E-value: 6.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  937 MENIMHSQNCEIKE-LKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEqSHLKELEDTLQvrhiqEFEKVMTDHRVSLE 1015
Cdd:pfam05483   50 LEQVANSGDCHYQEgLKDSDFENSEGLSRLYSKLYKEAEKIKKWKVSIE-AELKQKENKLQ-----ENRKIIEAQRKAIQ 123
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1016 ELKKENQQIINQIQEShaeiIQEKEKQLQElklkvSDLSDTRCKLEVELALKEAE-TDEIKILLEESRA----QQKETLK 1090
Cdd:pfam05483  124 ELQFENEKVSLKLEEE----IQENKDLIKE-----NNATRHLCNLLKETCARSAEkTKKYEYEREETRQvymdLNNNIEK 194
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1091 SLLEQETENLRTEISKLNQ--KIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESN------ILKAELNKVTSLH 1162
Cdd:pfam05483  195 MILAFEELRVQAENARLEMhfKLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKmkdltfLLEESRDKANQLE 274
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1163 NQAFEIEKNLKeQIIELQSKLDSELSALERQKDEKITQQeekyeaiiQNLEKDRQ---KLVSSQEQDREQLIQKLNCEKd 1239
Cdd:pfam05483  275 EKTKLQDENLK-ELIEKKDHLTKELEDIKMSLQRSMSTQ--------KALEEDLQiatKTICQLTEEKEAQMEELNKAK- 344
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1240 EAIQTALKEFKLEREVVEKELLEKVKHLENQiakspaidstRGDSSSLVAELQEKLQEekakfLEQLEEQEKRKNEEMQN 1319
Cdd:pfam05483  345 AAHSFVVTEFEATTCSLEELLRTEQQRLEKN----------EDQLKIITMELQKKSSE-----LEEMTKFKNNKEVELEE 409
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1320 VRTsLIAEQQTnfntvLTREKMRKENIINDLSDKLKS-TMQQQERDKDlIESLSEDRARLLEEKKKLEEEVSKLRsssfv 1398
Cdd:pfam05483  410 LKK-ILAEDEK-----LLDEKKQFEKIAEELKGKEQElIFLLQAREKE-IHDLEIQLTAIKTSEEHYLKEVEDLK----- 477
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034662293 1399 pspyvaTAPELYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLLERTLQLKE 1470
Cdd:pfam05483  478 ------TELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKE 543
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
843-1006 8.07e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 39.91  E-value: 8.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  843 EIRNIIEKVKcsLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQN-KDN-EFALVKHEK 920
Cdd:COG1579     21 RLEHRLKELP--AELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNvRNNkEYEALQKEI 98
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  921 EAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQShLKELEDTLQVRHI 1000
Cdd:COG1579     99 ESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAE-REELAAKIPPELL 177

                   ....*.
gi 1034662293 1001 QEFEKV 1006
Cdd:COG1579    178 ALYERI 183
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
903-1088 8.86e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 40.00  E-value: 8.86e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293   903 EEVLQNKDNEFALVKHEKEavicLQNEKD-----QKLLEmeNIMHSQNCEIKELKQSREIVLEDLKKLHVEND---EKLQ 974
Cdd:smart00787  109 PDVKLLMDKQFQLVKTFAR----LEAKKMwyewrMKLLE--GLKEGLDENLEGLKEDYKLLMKELELLNSIKPklrDRKD 182
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293   975 LLRAELQSLEQsHLKELEDTLQvrhiqefekvmTDHRVSLEELKKENQQIINQIQEshaeiIQEKEKQLQELKLKVSDLS 1054
Cdd:smart00787  183 ALEEELRQLKQ-LEDELEDCDP-----------TELDRAKEKLKKLLQEIMIKVKK-----LEELEEELQELESKIEDLT 245
                           170       180       190       200
                    ....*....|....*....|....*....|....*....|....
gi 1034662293  1055 DTrcKLEVELALKEAET----------DEIKILLEESRAQQKET 1088
Cdd:smart00787  246 NK--KSELNTEIAEAEKkleqcrgftfKEIEKLKEQLKLLQSLT 287
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
789-1113 9.24e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 40.98  E-value: 9.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  789 GDHTSLNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQcDFSNSLKCTAVEIRNIIEKVKCSLEITLK--EKHQKE 866
Cdd:pfam12128  576 GELNLYGVKLDLKRIDVPEWAASEEELRERLDKAEEALQSAR-EKQAAAEEQLVQANGELEKASREETFARTalKNARLD 654
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  867 LLSLKNEYEGKLDGLIKETEEN----ENKIKKLKGELVCLEEVLQnkdnefALVKHEKEAVICLQNEKDQKLLEMENIMH 942
Cdd:pfam12128  655 LRRLFDEKQSEKDKKNKALAERkdsaNERLNSLEAQLKQLDKKHQ------AWLEEQKEQKREARTEKQAYWQVVEGALD 728
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293  943 SQNCEIKELKQSREIVLE------------DLKKLHVENDeKLQLLRAELQSLEQShlkeLEDTLQVRHiqefeKVMTDH 1010
Cdd:pfam12128  729 AQLALLKAAIAARRSGAKaelkaletwykrDLASLGVDPD-VIAKLKREIRTLERK----IERIAVRRQ-----EVLRYF 798
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1011 RVSLEELKKENQQIINQIqeshAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLK 1090
Cdd:pfam12128  799 DWYQETWLQRRPRLATQL----SNIERAISELQQQLARLIADTKLRRAKLEMERKASEKQQVRLSENLRGLRCEMSKLAT 874
                          330       340
                   ....*....|....*....|...
gi 1034662293 1091 SLLEQETENLRTEISKLNQKIQD 1113
Cdd:pfam12128  875 LKEDANSEQAQGSIGERLAQLED 897
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
1014-1377 9.43e-03

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 40.61  E-value: 9.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1014 LEELKK-----ENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAEtdEIKILLEESRAQQKET 1088
Cdd:pfam06160   31 LSKVKKlnltgETQEKFEEWRKKWDDIVTKSLPDIEELLFEAEELNDKYRFKKAKKALDEIE--ELLDDIEEDIKQILEE 108
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1089 LKSLLEQETEN------LRTEISKLNQKIQDNNENYQVGLAELrtlmtiekdqciselisrhEEESNILKAELNKVTSL- 1161
Cdd:pfam06160  109 LDELLESEEKNreeveeLKDKYRELRKTLLANRFSYGPAIDEL-------------------EKQLAEIEEEFSQFEELt 169
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1162 ----HNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEkITQQEEKYEAIIQNLEKDRQKLvssQEQDREQLIQKLNCE 1237
Cdd:pfam06160  170 esgdYLEAREVLEKLEEETDALEELMEDIPPLYEELKTE-LPDQLEELKEGYREMEEEGYAL---EHLNVDKEIQQLEEQ 245
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1238 KDEAIQtALKEFKLER-EVVEKELLEKVKHLENQIAKspaidstrgdssslvaELQ-----EKLQEEKAKFLEQLEEQEK 1311
Cdd:pfam06160  246 LEENLA-LLENLELDEaEEALEEIEERIDQLYDLLEK----------------EVDakkyvEKNLPEIEDYLEHAEEQNK 308
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034662293 1312 RKNEEMQNVRTS------------LIAEQQTNFNTVLTREKMRKEN-------IINDLSDKLKSTMQQQERDKDLIESL- 1371
Cdd:pfam06160  309 ELKEELERVQQSytlnenelervrGLEKQLEELEKRYDEIVERLEEkevayseLQEELEEILEQLEEIEEEQEEFKESLq 388
                          410
                   ....*....|
gi 1034662293 1372 ----SEDRAR 1377
Cdd:pfam06160  389 slrkDELEAR 398
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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