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Conserved domains on  [gi|1034657633|ref|XP_016868357|]
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cyclin-D-binding Myb-like transcription factor 1 isoform X3 [Homo sapiens]

Protein Classification

cyclin-D-binding Myb-like transcription factor 1( domain architecture ID 13419776)

cyclin-D-binding Myb-like transcription factor 1 (DMTF1) is a transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest

Gene Symbol:  DMTF1
Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  8887674|8882580

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DMTF1_N pfam20588
Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the ...
 80-158 2.73e-22

Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the N-terminal of Cyclin-D-binding Myb-like transcription factor 1 (DMTF1), which is rich in acidic residues, adjacent pfam00249. DMTF1 is a tumour suppressor that interacts with and activates CDKN2A/ARF in response to Ras-Raf signalling, thus inducing p53-dependent cell cycle arrest.


:

Pssm-ID: 466737  Cd Length: 72  Bit Score: 90.94  E-value: 2.73e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034657633  80 ENDQSFEVTMTattEVADDEVTEGTVTQIQILQNEQLDeispLGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSK 158
Cdd:pfam20588   1 SPDKSFEVTMT---EVKDDELSERTKRQISKLENEKIN----LVIYEVSSVSQAIFTYKEDKDTLINKGHKWKQGIWYK 72
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 274-329 3.26e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 58.67  E-value: 3.26e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034657633 274 GKWTEEEEKRLAEVVHELtstepgdivtqGVSWAAVAERVGTRSEKQCRSKWLNYL 329
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKL-----------GNRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 228-284 9.70e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 55.01  E-value: 9.70e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034657633 228 TPEEIEKLKELRIKHGNDWATIGAALG-RSASSVKDR-CRLMKDTCNTGKWTEEEEKRL 284
Cdd:pfam13921   2 TEEEDEKLLKLVEKYGNDWKQIAKELGrRTPKQCFDRwRRKLNPKISRGPWSKEEDQRL 60
REB1 super family cl34920
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 105-438 4.12e-08

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5147:

Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 56.33  E-value: 4.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034657633 105 VTQIQILQNEQLDEISP--LGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKqgMWSKEEIDILMNNIERYLKargIKDATE 182
Cdd:COG5147   170 VPRVSKADVKPREKGEEnnPDIEDLQEMKELKSASITRHLILPSKSEINK--AFKKGETLALEQEINEYKE---KKGLSR 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034657633 183 IIFEMS-----KDERKDF--------YRTIAWGLNRplfavYRRVLRMYDDRnhvGKYTPEEIEKLKELRIKHGNDWATI 249
Cdd:COG5147   245 KQFCERiwstdRDEDKFWpniykklpYRDKKSIYKH-----LRRKYNIFEQR---GKWTKEEEQELAKLVVEHGGSWTEI 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034657633 250 GAALGRSASSVKDRCR---LMKDTCNTGKWTEEEEKRLAEVVHELTStepGDIVTQGVSWAAVAERVGTRSEKQCRSKWL 326
Cdd:COG5147   317 GKLLGRMPNDCRDRWRdyvKCGDTLKRNRWSIEEEELLDKVVNEMRL---EAQQSSRILWLLIAQNIRNRLQHHCRDKYG 393

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034657633 327 NYL---NWKQSGGTEWTKE--------DEINLILRIAELDVADENDINWDLLAEGWSSVRSPQWlrskwwtikrqianhk 395
Cdd:COG5147   394 VLIsnsSPFDAGAAIWLIErysnrkiqNGDLIKWRNSVLDSARRRMRDLKDLPEYALLLRTPDY---------------- 457

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1034657633 396 dvsfpvlikgLKQLHENQKNNPTLLENKSGSGVPNSNTNSSVQ 438
Cdd:COG5147   458 ----------NKSSLERIKKSAIDDGKKVLSLTLRELNKESSP 490
 
Name Accession Description Interval E-value
DMTF1_N pfam20588
Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the ...
 80-158 2.73e-22

Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the N-terminal of Cyclin-D-binding Myb-like transcription factor 1 (DMTF1), which is rich in acidic residues, adjacent pfam00249. DMTF1 is a tumour suppressor that interacts with and activates CDKN2A/ARF in response to Ras-Raf signalling, thus inducing p53-dependent cell cycle arrest.


Pssm-ID: 466737  Cd Length: 72  Bit Score: 90.94  E-value: 2.73e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034657633  80 ENDQSFEVTMTattEVADDEVTEGTVTQIQILQNEQLDeispLGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSK 158
Cdd:pfam20588   1 SPDKSFEVTMT---EVKDDELSERTKRQISKLENEKIN----LVIYEVSSVSQAIFTYKEDKDTLINKGHKWKQGIWYK 72
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 274-329 3.26e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 58.67  E-value: 3.26e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034657633 274 GKWTEEEEKRLAEVVHELtstepgdivtqGVSWAAVAERVGTRSEKQCRSKWLNYL 329
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKL-----------GNRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 228-284 9.70e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 55.01  E-value: 9.70e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034657633 228 TPEEIEKLKELRIKHGNDWATIGAALG-RSASSVKDR-CRLMKDTCNTGKWTEEEEKRL 284
Cdd:pfam13921   2 TEEEDEKLLKLVEKYGNDWKQIAKELGrRTPKQCFDRwRRKLNPKISRGPWSKEEDQRL 60
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 275-329 1.16e-09

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 54.12  E-value: 1.16e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034657633 275 KWTEEEEKRLAEVVHELtstepGDIvtqgvSWAAVAERVGTRSEKQCRSKWLNYL 329
Cdd:cd00167     1 PWTEEEDELLLEAVKKY-----GKN-----NWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
274-330 1.78e-09

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 53.77  E-value: 1.78e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034657633  274 GKWTEEEEKRLAEVVHELtstepGDIvtqgvSWAAVAERVGTRSEKQCRSKWLNYLN 330
Cdd:smart00717   2 GEWTEEEDELLIELVKKY-----GKN-----NWEKIAKELPGRTAEQCRERWRNLLK 48
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 105-438 4.12e-08

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 56.33  E-value: 4.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034657633 105 VTQIQILQNEQLDEISP--LGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKqgMWSKEEIDILMNNIERYLKargIKDATE 182
Cdd:COG5147   170 VPRVSKADVKPREKGEEnnPDIEDLQEMKELKSASITRHLILPSKSEINK--AFKKGETLALEQEINEYKE---KKGLSR 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034657633 183 IIFEMS-----KDERKDF--------YRTIAWGLNRplfavYRRVLRMYDDRnhvGKYTPEEIEKLKELRIKHGNDWATI 249
Cdd:COG5147   245 KQFCERiwstdRDEDKFWpniykklpYRDKKSIYKH-----LRRKYNIFEQR---GKWTKEEEQELAKLVVEHGGSWTEI 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034657633 250 GAALGRSASSVKDRCR---LMKDTCNTGKWTEEEEKRLAEVVHELTStepGDIVTQGVSWAAVAERVGTRSEKQCRSKWL 326
Cdd:COG5147   317 GKLLGRMPNDCRDRWRdyvKCGDTLKRNRWSIEEEELLDKVVNEMRL---EAQQSSRILWLLIAQNIRNRLQHHCRDKYG 393

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034657633 327 NYL---NWKQSGGTEWTKE--------DEINLILRIAELDVADENDINWDLLAEGWSSVRSPQWlrskwwtikrqianhk 395
Cdd:COG5147   394 VLIsnsSPFDAGAAIWLIErysnrkiqNGDLIKWRNSVLDSARRRMRDLKDLPEYALLLRTPDY---------------- 457

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1034657633 396 dvsfpvlikgLKQLHENQKNNPTLLENKSGSGVPNSNTNSSVQ 438
Cdd:COG5147   458 ----------NKSSLERIKKSAIDDGKKVLSLTLRELNKESSP 490
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
225-270 1.46e-06

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 45.29  E-value: 1.46e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1034657633  225 GKYTPEEIEKLKELRIKHG-NDWATIGAALG-RSASSVKDRCRLMKDT 270
Cdd:smart00717   2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPgRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 226-268 1.81e-06

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 45.26  E-value: 1.81e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1034657633 226 KYTPEEIEKLKELRIKHG-NDWATIGAALG-RSASSVKDRCRLMK 268
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPgRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
336-389 6.35e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 37.97  E-value: 6.35e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1034657633  336 GTEWTKEDEINLILRIAELDVadendINWDLLAEGWSSvRSPQWLRSKWWTIKR 389
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGK-----NNWEKIAKELPG-RTAEQCRERWRNLLK 48
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 338-388 5.00e-03

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 35.24  E-value: 5.00e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034657633 338 EWTKEDEINLILRIAELDVadendINWDLLAEGWSSvRSPQWLRSKWWTIK 388
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGK-----NNWEKIAKELPG-RTPKQCRERWRNLL 45
 
Name Accession Description Interval E-value
DMTF1_N pfam20588
Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the ...
 80-158 2.73e-22

Cyclin-D-binding Myb-like transcription factor 1 N-terminal; This domain is found at the N-terminal of Cyclin-D-binding Myb-like transcription factor 1 (DMTF1), which is rich in acidic residues, adjacent pfam00249. DMTF1 is a tumour suppressor that interacts with and activates CDKN2A/ARF in response to Ras-Raf signalling, thus inducing p53-dependent cell cycle arrest.


Pssm-ID: 466737  Cd Length: 72  Bit Score: 90.94  E-value: 2.73e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034657633  80 ENDQSFEVTMTattEVADDEVTEGTVTQIQILQNEQLDeispLGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSK 158
Cdd:pfam20588   1 SPDKSFEVTMT---EVKDDELSERTKRQISKLENEKIN----LVIYEVSSVSQAIFTYKEDKDTLINKGHKWKQGIWYK 72
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 274-329 3.26e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 58.67  E-value: 3.26e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034657633 274 GKWTEEEEKRLAEVVHELtstepgdivtqGVSWAAVAERVGTRSEKQCRSKWLNYL 329
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKL-----------GNRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 228-284 9.70e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 55.01  E-value: 9.70e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034657633 228 TPEEIEKLKELRIKHGNDWATIGAALG-RSASSVKDR-CRLMKDTCNTGKWTEEEEKRL 284
Cdd:pfam13921   2 TEEEDEKLLKLVEKYGNDWKQIAKELGrRTPKQCFDRwRRKLNPKISRGPWSKEEDQRL 60
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 275-329 1.16e-09

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 54.12  E-value: 1.16e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034657633 275 KWTEEEEKRLAEVVHELtstepGDIvtqgvSWAAVAERVGTRSEKQCRSKWLNYL 329
Cdd:cd00167     1 PWTEEEDELLLEAVKKY-----GKN-----NWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
274-330 1.78e-09

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 53.77  E-value: 1.78e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034657633  274 GKWTEEEEKRLAEVVHELtstepGDIvtqgvSWAAVAERVGTRSEKQCRSKWLNYLN 330
Cdd:smart00717   2 GEWTEEEDELLIELVKKY-----GKN-----NWEKIAKELPGRTAEQCRERWRNLLK 48
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 225-268 3.39e-08

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 49.81  E-value: 3.39e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1034657633 225 GKYTPEEIEKLKELRIKHGNDWATIGAAL-GRSASSVKDRCRLMK 268
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKLGNRWKKIAKLLpGRTDNQCKNRWQNYL 46
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 105-438 4.12e-08

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 56.33  E-value: 4.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034657633 105 VTQIQILQNEQLDEISP--LGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKqgMWSKEEIDILMNNIERYLKargIKDATE 182
Cdd:COG5147   170 VPRVSKADVKPREKGEEnnPDIEDLQEMKELKSASITRHLILPSKSEINK--AFKKGETLALEQEINEYKE---KKGLSR 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034657633 183 IIFEMS-----KDERKDF--------YRTIAWGLNRplfavYRRVLRMYDDRnhvGKYTPEEIEKLKELRIKHGNDWATI 249
Cdd:COG5147   245 KQFCERiwstdRDEDKFWpniykklpYRDKKSIYKH-----LRRKYNIFEQR---GKWTKEEEQELAKLVVEHGGSWTEI 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034657633 250 GAALGRSASSVKDRCR---LMKDTCNTGKWTEEEEKRLAEVVHELTStepGDIVTQGVSWAAVAERVGTRSEKQCRSKWL 326
Cdd:COG5147   317 GKLLGRMPNDCRDRWRdyvKCGDTLKRNRWSIEEEELLDKVVNEMRL---EAQQSSRILWLLIAQNIRNRLQHHCRDKYG 393

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034657633 327 NYL---NWKQSGGTEWTKE--------DEINLILRIAELDVADENDINWDLLAEGWSSVRSPQWlrskwwtikrqianhk 395
Cdd:COG5147   394 VLIsnsSPFDAGAAIWLIErysnrkiqNGDLIKWRNSVLDSARRRMRDLKDLPEYALLLRTPDY---------------- 457

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1034657633 396 dvsfpvlikgLKQLHENQKNNPTLLENKSGSGVPNSNTNSSVQ 438
Cdd:COG5147   458 ----------NKSSLERIKKSAIDDGKKVLSLTLRELNKESSP 490
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 276-347 5.59e-07

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 46.92  E-value: 5.59e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034657633 276 WTEEEEKRLAEVVHELTSTepgdivtqgvsWAAVAERVGTRSEKQCRSKWLNYLNWKQSGGtEWTKEDEINL 347
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGND-----------WKQIAKELGRRTPKQCFDRWRRKLNPKISRG-PWSKEEDQRL 60
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
225-270 1.46e-06

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 45.29  E-value: 1.46e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1034657633  225 GKYTPEEIEKLKELRIKHG-NDWATIGAALG-RSASSVKDRCRLMKDT 270
Cdd:smart00717   2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPgRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 226-268 1.81e-06

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 45.26  E-value: 1.81e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1034657633 226 KYTPEEIEKLKELRIKHG-NDWATIGAALG-RSASSVKDRCRLMK 268
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPgRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
336-389 6.35e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 37.97  E-value: 6.35e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1034657633  336 GTEWTKEDEINLILRIAELDVadendINWDLLAEGWSSvRSPQWLRSKWWTIKR 389
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGK-----NNWEKIAKELPG-RTAEQCRERWRNLLK 48
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 338-388 5.00e-03

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 35.24  E-value: 5.00e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034657633 338 EWTKEDEINLILRIAELDVadendINWDLLAEGWSSvRSPQWLRSKWWTIK 388
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGK-----NNWEKIAKELPG-RTPKQCRERWRNLL 45
Myb_DNA-bind_4 pfam13837
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb ...
 275-327 8.78e-03

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT-like DNA binding domains. In particular pfam10545 seems most related. This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.


Pssm-ID: 463994  Cd Length: 84  Bit Score: 35.70  E-value: 8.78e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034657633 275 KWTEEEEKRLAEVVHEL------TSTEPGDIVTQGVSwAAVAERVGTRSEKQCRSKWLN 327
Cdd:pfam13837   3 KWTEEETLALIEIWGERlelrfqESKKRNKKLWEEIA-EKMAELGYNRSPEQCKEKWEN 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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