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Conserved domains on  [gi|1034655641|ref|XP_016867700|]
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importin subunit alpha-8 isoform X8 [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
34-516 4.01e-155

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 452.81  E-value: 4.01e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641  34 PEERRRKFKYRGK-DVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDTPSEKTAKGVAVSLTLGEIIKGVNSSDPV 112
Cdd:COG5064     7 PEARRYNFKGKGRfSADELRRRREEQQVELRKQKREELLNKRRNLADVSEEAESSFIPMEQQFYSELPQLTQQLFSDDIE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641 113 LCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELL 192
Cdd:COG5064    87 QQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641 193 SSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALI-SPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILP 271
Cdd:COG5064   167 SSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALP 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641 272 ALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDA 351
Cdd:COG5064   247 ILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINC 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641 352 GMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATM--DQ 429
Cdd:COG5064   327 GALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLNrpDI 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641 430 LIQLVHSGVLEPLVNLLTAPDVKIVLIILDVISCILQAAE----KRSEKENL-CLLIEELGGIDRIEALQLHENRQIGQS 504
Cdd:COG5064   407 IRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqdrlRYGKNINIyAVYVEKAGGMDAIHGLQDSVNRTIYDK 486

                         490
                  ....*....|..
gi 1034655641 505 ALNIIEKHFGEK 516
Cdd:COG5064   487 AYSIIEKFFGEE 498
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
34-516 4.01e-155

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 452.81  E-value: 4.01e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641  34 PEERRRKFKYRGK-DVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDTPSEKTAKGVAVSLTLGEIIKGVNSSDPV 112
Cdd:COG5064     7 PEARRYNFKGKGRfSADELRRRREEQQVELRKQKREELLNKRRNLADVSEEAESSFIPMEQQFYSELPQLTQQLFSDDIE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641 113 LCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELL 192
Cdd:COG5064    87 QQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641 193 SSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALI-SPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILP 271
Cdd:COG5064   167 SSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALP 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641 272 ALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDA 351
Cdd:COG5064   247 ILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINC 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641 352 GMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATM--DQ 429
Cdd:COG5064   327 GALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLNrpDI 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641 430 LIQLVHSGVLEPLVNLLTAPDVKIVLIILDVISCILQAAE----KRSEKENL-CLLIEELGGIDRIEALQLHENRQIGQS 504
Cdd:COG5064   407 IRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqdrlRYGKNINIyAVYVEKAGGMDAIHGLQDSVNRTIYDK 486

                         490
                  ....*....|..
gi 1034655641 505 ALNIIEKHFGEK 516
Cdd:COG5064   487 AYSIIEKFFGEE 498
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 37-119 5.81e-25

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 97.99  E-value: 5.81e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641  37 RRRKFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNIT-SFCPDTPSEKTakgvaVSLTLGEIIKGVNSSDPVLCF 115
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGaPSSSSSSAESQ-----LLESLPEMVQGVNSDDPELQL 75


                  ....
gi 1034655641 116 QATQ 119
Cdd:pfam01749  76 EATQ 79
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 341-381 5.10e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.96  E-value: 5.10e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1034655641  341 TDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAA 381
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 158-420 1.76e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 44.71  E-value: 1.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641  158 QFEAAWALTNIASGTSEQTR-AVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALIsp 236
Cdd:PLN03200   462 QQEYAVALLAILTDEVDESKwAITAAGGIPPLVQLLETGSQKAKEDSATVLWNLCCHSEDIRACVESAGAVPALLWLL-- 539

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641  237 tlpitflrnitwtlsnlcRNKNPYPCDTAVKqilpALLHLLQHQDSEVLSDacwALSYLTDGSNKRIGQVVNtgVLPRlv 316
Cdd:PLN03200   540 ------------------KNGGPKGQEIAAK----TLTKLVRTADAATISQ---LTALLLGDLPESKVHVLD--VLGH-- 590

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641  317 VLMTSSELNVLTP------SLRTVGNIVTGTDEQTQ--------------------MAIDAgMLNVLPQLLQHNKPSIQK 370
Cdd:PLN03200   591 VLSVASLEDLVREgsaandALRTLIQLLSSSKEETQekaasvladifssrqdlcesLATDE-IINPCIKLLTNNTEAVAT 669

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1034655641  371 EAAWALSNVaAGPCHHIQQL--LAYDVLPPLVALLKNGEFKVQKEAVWMVAN 420
Cdd:PLN03200   670 QSARALAAL-SRSIKENRKVsyAAEDAIKPLIKLAKSSSIEVAEQAVCALAN 720
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
34-516 4.01e-155

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 452.81  E-value: 4.01e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641  34 PEERRRKFKYRGK-DVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDTPSEKTAKGVAVSLTLGEIIKGVNSSDPV 112
Cdd:COG5064     7 PEARRYNFKGKGRfSADELRRRREEQQVELRKQKREELLNKRRNLADVSEEAESSFIPMEQQFYSELPQLTQQLFSDDIE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641 113 LCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELL 192
Cdd:COG5064    87 QQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641 193 SSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALI-SPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILP 271
Cdd:COG5064   167 SSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALP 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641 272 ALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDA 351
Cdd:COG5064   247 ILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINC 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641 352 GMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATM--DQ 429
Cdd:COG5064   327 GALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGLNrpDI 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641 430 LIQLVHSGVLEPLVNLLTAPDVKIVLIILDVISCILQAAE----KRSEKENL-CLLIEELGGIDRIEALQLHENRQIGQS 504
Cdd:COG5064   407 IRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqdrlRYGKNINIyAVYVEKAGGMDAIHGLQDSVNRTIYDK 486

                         490
                  ....*....|..
gi 1034655641 505 ALNIIEKHFGEK 516
Cdd:COG5064   487 AYSIIEKFFGEE 498
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 37-119 5.81e-25

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 97.99  E-value: 5.81e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641  37 RRRKFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNIT-SFCPDTPSEKTakgvaVSLTLGEIIKGVNSSDPVLCF 115
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGaPSSSSSSAESQ-----LLESLPEMVQGVNSDDPELQL 75


                  ....
gi 1034655641 116 QATQ 119
Cdd:pfam01749  76 EATQ 79
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 479-515 3.05e-14

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 66.84  E-value: 3.05e-14
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1034655641 479 LLIEELGGIDRIEALQLHENRQIGQSALNIIEKHFGE 515
Cdd:pfam16186   1 LLIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSD 37
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 341-381 1.45e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 53.23  E-value: 1.45e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034655641 341 TDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAA 381
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 172-211 2.44e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 52.84  E-value: 2.44e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1034655641 172 TSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIA 211
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 341-381 5.10e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.96  E-value: 5.10e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1034655641  341 TDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAA 381
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 172-211 6.98e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.58  E-value: 6.98e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1034655641  172 TSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIA 211
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 157-210 5.04e-07

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 46.59  E-value: 5.04e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034655641 157 LQFEAAWALTNIASGTSEQTRAVVEGgAIQPLIELLSSSNVAVCEQAVWALGNI 210
Cdd:pfam13513   3 VREAAALALGSLAEGGPDLLAPAVPE-LLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
142-292 6.40e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 48.86  E-value: 6.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641 142 IPRMVEFLKSSlYPCLQFEAAWALTNIASGTseqtravveggAIQPLIELLSSSNVAVCEQAVWALGNIAgdgpefrdnv 221
Cdd:COG1413    18 VPALIAALADE-DPDVRAAAARALGRLGDPR-----------AVPALLEALKDPDPEVRAAAAEALGRIG---------- 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034655641 222 iTSNAIPHLL-ALISPTLPITflRNITWTLSNLcrnknpypcdtAVKQILPALLHLLQHQDSEVLSDACWAL 292
Cdd:COG1413    76 -DPEAVPALIaALKDEDPEVR--RAAAEALGRL-----------GDPAAVPALLEALKDPDWEVRRAAARAL 133
HEAT COG1413
HEAT repeat [General function prediction only];
161-297 8.46e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 48.47  E-value: 8.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641 161 AAWALTNIasGTSEqtravveggAIQPLIELLSSSNVAVCEQAVWALGNIAGDGpefrdnvitsnAIPHLLALISPTLPI 240
Cdd:COG1413     5 AARALGRL--GDPA---------AVPALIAALADEDPDVRAAAARALGRLGDPR-----------AVPALLEALKDPDPE 62

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034655641 241 TfLRNITWTLSNLcrnknpypcdtAVKQILPALLHLLQHQDSEVLSDACWALSYLTD 297
Cdd:COG1413    63 V-RAAAAEALGRI-----------GDPEAVPALIAALKDEDPEVRRAAAEALGRLGD 107
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 269-297 1.63e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 44.75  E-value: 1.63e-06
                          10        20
                  ....*....|....*....|....*....
gi 1034655641 269 ILPALLHLLQHQDSEVLSDACWALSYLTD 297
Cdd:pfam00514  13 AVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 258-297 1.38e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 42.03  E-value: 1.38e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1034655641  258 NPYPCDTAVKQ-ILPALLHLLQHQDSEVLSDACWALSYLTD 297
Cdd:smart00185   1 DDENKQAVVDAgGLPALVELLKSEDEEVVKEAAWALSNLSS 41
HEAT COG1413
HEAT repeat [General function prediction only];
267-416 1.80e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 44.62  E-value: 1.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641 267 KQILPALLHLLQHQDSEVLSDACWALSYLTDgsnkrigqvvnTGVLPRLVVLMTSSELNVLTPSLRTVGNIvtGTDEqtq 346
Cdd:COG1413    15 PAAVPALIAALADEDPDVRAAAARALGRLGD-----------PRAVPALLEALKDPDPEVRAAAAEALGRI--GDPE--- 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641 347 mAIDAgmlnvLPQLLQHNKPSIQKEAAWALSNVAAGpchhiqqllayDVLPPLVALLKNGEFKVQKEAVW 416
Cdd:COG1413    79 -AVPA-----LIAALKDEDPEVRRAAAEALGRLGDP-----------AAVPALLEALKDPDWEVRRAAAR 131
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 130-170 1.74e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 38.97  E-value: 1.74e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034655641 130 NPPLKLVIEAGLIPRMVEFLKSSlYPCLQFEAAWALTNIAS 170
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSP-DEEVQEEAAWALSNLAA 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 158-420 1.76e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 44.71  E-value: 1.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641  158 QFEAAWALTNIASGTSEQTR-AVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALIsp 236
Cdd:PLN03200   462 QQEYAVALLAILTDEVDESKwAITAAGGIPPLVQLLETGSQKAKEDSATVLWNLCCHSEDIRACVESAGAVPALLWLL-- 539

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641  237 tlpitflrnitwtlsnlcRNKNPYPCDTAVKqilpALLHLLQHQDSEVLSDacwALSYLTDGSNKRIGQVVNtgVLPRlv 316
Cdd:PLN03200   540 ------------------KNGGPKGQEIAAK----TLTKLVRTADAATISQ---LTALLLGDLPESKVHVLD--VLGH-- 590

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641  317 VLMTSSELNVLTP------SLRTVGNIVTGTDEQTQ--------------------MAIDAgMLNVLPQLLQHNKPSIQK 370
Cdd:PLN03200   591 VLSVASLEDLVREgsaandALRTLIQLLSSSKEETQekaasvladifssrqdlcesLATDE-IINPCIKLLTNNTEAVAT 669

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1034655641  371 EAAWALSNVaAGPCHHIQQL--LAYDVLPPLVALLKNGEFKVQKEAVWMVAN 420
Cdd:PLN03200   670 QSARALAAL-SRSIKENRKVsyAAEDAIKPLIKLAKSSSIEVAEQAVCALAN 720
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 129-170 2.00e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.95  E-value: 2.00e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1034655641  129 KNPPLKLVIEAGLIPRMVEFLKSSlYPCLQFEAAWALTNIAS 170
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSE-DEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 385-423 3.09e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 38.20  E-value: 3.09e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1034655641 385 HHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFAT 423
Cdd:pfam00514   3 ENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 366-421 5.89e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.12  E-value: 5.89e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034655641 366 PSIQKEAAWALSNVAaGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANF 421
Cdd:pfam13513   1 WRVREAAALALGSLA-EGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 224-415 9.60e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 42.01  E-value: 9.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641  224 SNAIPHLLALI-SPTLPITFlrNITWTLSNLCRNKnpypcDTAVKQIL----PALLHLLQHQDSE---VLSDACWALSyl 295
Cdd:PLN03200    57 SQAMPLLVSLLrSGTLGAKV--NAAAVLGVLCKEE-----DLRVKVLLggciPPLLSLLKSGSAEaqkAAAEAIYAVS-- 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641  296 TDGSNKRIGQ--VVNTGVLPRLVVLMTS------SELNVLTPSLRtvgNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPS 367
Cdd:PLN03200   128 SGGLSDHVGSkiFSTEGVVPSLWDQLQPgnkqdkVVEGLLTGALR---NLCGSTDGFWSATLEAGGVDILVKLLSSGNSD 204

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1034655641  368 IQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNG-EFKVQKEAV 415
Cdd:PLN03200   205 AQANAASLLARLMMAFESSISKVLDAGAVKQLLKLLGQGnEVSVRAEAA 253
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 244-295 1.19e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 36.96  E-value: 1.19e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034655641 244 RNITWTLSNLCrNKNPYPCDTAVKQILPALLHLLQHQDSEVLSDACWALSYL 295
Cdd:pfam13513   5 EAAALALGSLA-EGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 215-255 1.20e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.66  E-value: 1.20e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034655641 215 PEFRDNVITSNAIPHLLALISPTlPITFLRNITWTLSNLCR 255
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSP-DEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 299-339 1.64e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.28  E-value: 1.64e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034655641 299 SNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVT 339
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 142-234 3.37e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.93  E-value: 3.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641 142 IPRMVEFLKSSLYPCLQFEAAWALTNIASGTseqtravveggAIQPLIELLSSSNVAVCEQAVWALGNIAgdgpefrdnv 221
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALGRIGDPE-----------AVPALLELLKDEDPAVRRAAAEALGKIG---------- 59

                          90
                  ....*....|...
gi 1034655641 222 iTSNAIPHLLALI 234
Cdd:pfam13646  60 -DPEALPALLELL 71
HEAT COG1413
HEAT repeat [General function prediction only];
142-211 4.03e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 37.69  E-value: 4.03e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641 142 IPRMVEFLKSSlYPCLQFEAAWALTNIASGTseqtravveggAIQPLIELLSSSNVAVCEQAVWALGNIA 211
Cdd:COG1413    80 VPALIAALKDE-DPEVRRAAAEALGRLGDPA-----------AVPALLEALKDPDWEVRRAAARALGRLG 137
HEAT COG1413
HEAT repeat [General function prediction only];
350-436 5.02e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 37.30  E-value: 5.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641 350 DAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGpchhiqqllayDVLPPLVALLKNGEFKVQKEAVWMVANFATGATMDQ 429
Cdd:COG1413    14 DPAAVPALIAALADEDPDVRAAAARALGRLGDP-----------RAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPA 82


                  ....*..
gi 1034655641 430 LIQLVHS 436
Cdd:COG1413    83 LIAALKD 89
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 121-237 5.86e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 39.70  E-value: 5.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641  121 ARKMLSQEKNPPLKLVIEAGLIPRMVEFLKSSlYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSN-VAV 199
Cdd:PLN03200   170 ALRNLCGSTDGFWSATLEAGGVDILVKLLSSG-NSDAQANAASLLARLMMAFESSISKVLDAGAVKQLLKLLGQGNeVSV 248

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1034655641  200 CEQAVWALGNIAGDGPEFRDNVITSNAIPHLL-ALISPT 237
Cdd:PLN03200   249 RAEAAGALEALSSQSKEAKQAIADAGGIPALInATVAPS 287
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 337-468 6.83e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 39.32  E-value: 6.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034655641  337 IVTGTDEQTQMAID-AGMLNVLPQLLQHNKPSIQKEAAWALSNVaagpCHHIQQLLA----YDVLPPLVALLKNGEFKVQ 411
Cdd:PLN03200   472 ILTDEVDESKWAITaAGGIPPLVQLLETGSQKAKEDSATVLWNL----CCHSEDIRAcvesAGAVPALLWLLKNGGPKGQ 547

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034655641  412 KEAVwmvanfatgATMDQLIQLVHSGVLEPLVNLLT--APDVKIVliILDVISCILQAA 468
Cdd:PLN03200   548 EIAA---------KTLTKLVRTADAATISQLTALLLgdLPESKVH--VLDVLGHVLSVA 595
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 385-422 6.85e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 34.33  E-value: 6.85e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1034655641  385 HHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFA 422
Cdd:smart00185   3 ENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 160-214 9.70e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 38.93  E-value: 9.70e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034655641  160 EAAWALTNIASGTSE-QTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDG 214
Cdd:PLN03200   670 QSARALAALSRSIKEnRKVSYAAEDAIKPLIKLAKSSSIEVAEQAVCALANLLSDP 725
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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