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Conserved domains on  [gi|1034654171|ref|XP_016867247|]
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ankyrin repeat and SOCS box protein 15 isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
20-249 3.96e-32

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.53  E-value: 3.96e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  20 WSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPD 99
Cdd:COG0666    22 ALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 100 CISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLI----PVtskNAIRKSGLTPIHSAADGQNAQCLELLIENGFD 175
Cdd:COG0666   102 IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLeagaDV---NAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034654171 176 VNTLladhisqsyDDERKTALYFGVSNNDVHCTEVLLAAGADPNL---DPLNCLLVAVRANNYEIVRLLLSHGANVN 249
Cdd:COG0666   179 VNAR---------DNDGETPLHLAAENGHLEIVKLLLEAGADVNAkdnDGKTALDLAAENGNLEIVKLLLEAGADLN 246
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 374-429 1.74e-31

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239701  Cd Length: 56  Bit Score: 114.54  E-value: 1.74e-31
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034654171 374 ENPCSLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKEYDLYGQELKL 429
Cdd:cd03731     1 ENPRPLKHLCRLKIRKLMGLQKLQQPSSMKKLPLPPALKRYILYKEYDLYGQELKL 56
PHA03100 super family cl39094
ankyrin repeat protein; Provisional
 219-289 8.03e-03

ankyrin repeat protein; Provisional


The actual alignment was detected with superfamily member PHA03100:

Pssm-ID: 476869 [Multi-domain]  Cd Length: 422  Bit Score: 38.49  E-value: 8.03e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034654171 219 NLDPLNCLLVAVRANNYEIVRLLLSHGANVNCYFM-HVNDTRFPSVIQYALNDEV-MLRLLLNNGYQVEMCFD 289
Cdd:PHA03100   32 YKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKnNSTPLHYLSNIKYNLTDVKeIVKLLLEYGANVNAPDN 104
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
20-249 3.96e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.53  E-value: 3.96e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  20 WSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPD 99
Cdd:COG0666    22 ALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 100 CISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLI----PVtskNAIRKSGLTPIHSAADGQNAQCLELLIENGFD 175
Cdd:COG0666   102 IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLeagaDV---NAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034654171 176 VNTLladhisqsyDDERKTALYFGVSNNDVHCTEVLLAAGADPNL---DPLNCLLVAVRANNYEIVRLLLSHGANVN 249
Cdd:COG0666   179 VNAR---------DNDGETPLHLAAENGHLEIVKLLLEAGADVNAkdnDGKTALDLAAENGNLEIVKLLLEAGADLN 246
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 374-429 1.74e-31

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 114.54  E-value: 1.74e-31
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034654171 374 ENPCSLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKEYDLYGQELKL 429
Cdd:cd03731     1 ENPRPLKHLCRLKIRKLMGLQKLQQPSSMKKLPLPPALKRYILYKEYDLYGQELKL 56
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 4-286 9.68e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 81.64  E-value: 9.68e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171   4 TLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHcdVLEHlihkggdvlalad 83
Cdd:PHA03100   20 YIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKY--NLTD------------- 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  84 dgasvlfeaagggNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYE--GHYLALKYLIPVTSK-NAIRKSGLTPIHSAADG 160
Cdd:PHA03100   85 -------------VKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANvNIKNSDGENLLHLYLES 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 161 --QNAQCLELLIENGFDVNT------LLADHISQSYDDER-KTALYFGVSNNDVHCTEVLLAAGADPNLDPLN---CLLV 228
Cdd:PHA03100  152 nkIDLKILKLLIDKGVDINAknrvnyLLSYGVPINIKDVYgFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYgdtPLHI 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034654171 229 AVRANNYEIVRLLLSHGANVN---CYFMHVNDTRFPSVIQYAL-NDEVMLRLLLNNGYQVEM 286
Cdd:PHA03100  232 AILNNNKEIFKLLLNNGPSIKtiiETLLYFKDKDLNTITKIKMlKKSIMYMFLLDPGFYKNR 293
Ank_2 pfam12796
Ankyrin repeats (3 copies);
89-178 2.71e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.22  E-value: 2.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  89 LFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNaIRKSGLTPIHSAADGQNAQCLEL 168
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN-LKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|
gi 1034654171 169 LIENGFDVNT 178
Cdd:pfam12796  80 LLEKGADINV 89
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 375-416 2.26e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 58.33  E-value: 2.26e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034654171 375 NPCSLKHLCRLKIRRLMGLQKLCQpasVEKLPLPPAIQRYIL 416
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGA---IDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 377-418 1.55e-08

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 50.10  E-value: 1.55e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1034654171  377 CSLKHLCRLKIRRLMGLqklcqpasVEKLPLPPAIQRYILFK 418
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG--------IDKLPLPPRLKDYLLYY 34
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 85-249 1.90e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 47.00  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  85 GASVLFEAAGGGNP-DCISLLLEYGGSGNVpnraGHLPIHRAA---YEGHYLALKYLIPVTSK-------NAIRKS---- 149
Cdd:TIGR00870  52 GRSALFVAAIENENlELTELLLNLSCRGAV----GDTLLHAISleyVDAVEAILLHLLAAFRKsgplelaNDQYTSeftp 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 150 GLTPIHSAADGQNAQCLELLIENGFDVN---TLLADHISQsyddeRKTALYFGVSnndvhctevllaagadpnldPLN-- 224
Cdd:TIGR00870 128 GITALHLAAHRQNYEIVKLLLERGASVParaCGDFFVKSQ-----GVDSFYHGES--------------------PLNaa 182

                         170       180
                  ....*....|....*....|....*.
gi 1034654171 225 -CLlvavraNNYEIVRLLLSHGANVN 249
Cdd:TIGR00870 183 aCL------GSPSIVALLSEDPADIL 202
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 87-248 4.01e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.69  E-value: 4.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  87 SVLFEAAGGGNPDCISLLLEYGgSGNVPNRA--GHLPIHRAAYEGHYLALKYLI---PVTSKNAIRKS---GLTPIHSAA 158
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLLKCP-SCDLFQRGalGETALHVAALYDNLEAAVVLMeaaPELVNEPMTSDlyqGETALHIAV 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 159 DGQNAQCLELLIENGFDVNTlladhisqsyddERKTALYFGVSNndvHCtevLLAAGADPnldplncLLVAVRANNYEIV 238
Cdd:cd22192    98 VNQNLNLVRELIARGADVVS------------PRATGTFFRPGP---KN---LIYYGEHP-------LSFAACVGNEEIV 152

                         170
                  ....*....|
gi 1034654171 239 RLLLSHGANV 248
Cdd:cd22192   153 RLLIEHGADI 162
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 224-250 1.11e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 1.11e-03
                           10        20
                   ....*....|....*....|....*..
gi 1034654171  224 NCLLVAVRANNYEIVRLLLSHGANVNC 250
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 219-289 8.03e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 38.49  E-value: 8.03e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034654171 219 NLDPLNCLLVAVRANNYEIVRLLLSHGANVNCYFM-HVNDTRFPSVIQYALNDEV-MLRLLLNNGYQVEMCFD 289
Cdd:PHA03100   32 YKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKnNSTPLHYLSNIKYNLTDVKeIVKLLLEYGANVNAPDN 104
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
20-249 3.96e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.53  E-value: 3.96e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  20 WSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPD 99
Cdd:COG0666    22 ALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLE 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 100 CISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLI----PVtskNAIRKSGLTPIHSAADGQNAQCLELLIENGFD 175
Cdd:COG0666   102 IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLeagaDV---NAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034654171 176 VNTLladhisqsyDDERKTALYFGVSNNDVHCTEVLLAAGADPNL---DPLNCLLVAVRANNYEIVRLLLSHGANVN 249
Cdd:COG0666   179 VNAR---------DNDGETPLHLAAENGHLEIVKLLLEAGADVNAkdnDGKTALDLAAENGNLEIVKLLLEAGADLN 246
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-224 8.42e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 122.76  E-value: 8.42e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171   1 MVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLA 80
Cdd:COG0666    69 VALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNA 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  81 LADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIpvtSK----NAIRKSGLTPIHS 156
Cdd:COG0666   149 QDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLL---EAgadvNAKDNDGKTALDL 225

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034654171 157 AADGQNAQCLELLIENGFDVNTLladhisqsyDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLN 224
Cdd:COG0666   226 AAENGNLEIVKLLLEAGADLNAK---------DKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLD 284
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
22-249 8.59e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 122.76  E-value: 8.59e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  22 AMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCI 101
Cdd:COG0666    57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIV 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 102 SLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLI----PVtskNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVN 177
Cdd:COG0666   137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLeagaDV---NARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034654171 178 TLladhisqsyDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLNC---LLVAVRANNYEIVRLLLSHGANVN 249
Cdd:COG0666   214 AK---------DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGltaLLLAAAAGAALIVKLLLLALLLLA 279
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 374-429 1.74e-31

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 114.54  E-value: 1.74e-31
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034654171 374 ENPCSLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKEYDLYGQELKL 429
Cdd:cd03731     1 ENPRPLKHLCRLKIRKLMGLQKLQQPSSMKKLPLPPALKRYILYKEYDLYGQELKL 56
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
33-281 5.53e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 106.58  E-value: 5.53e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  33 DIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGN 112
Cdd:COG0666     2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 113 VPNRAGHLPIHRAAYEGHYLALKYLI----PVtskNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLladhisqsy 188
Cdd:COG0666    82 AKDDGGNTLLHAAARNGDLEIVKLLLeagaDV---NARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQ--------- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 189 DDERKTALYFGVSNNDVHCTEVLLAAGADPNL---DPLNCLLVAVRANNYEIVRLLLSHGANVNcyfMHVNDTRFPSVIQ 265
Cdd:COG0666   150 DNDGNTPLHLAAANGNLEIVKLLLEAGADVNArdnDGETPLHLAAENGHLEIVKLLLEAGADVN---AKDNDGKTALDLA 226

                         250
                  ....*....|....*.
gi 1034654171 266 YALNDEVMLRLLLNNG 281
Cdd:COG0666   227 AENGNLEIVKLLLEAG 242
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-155 3.44e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 101.57  E-value: 3.44e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171   1 MVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLA 80
Cdd:COG0666   135 IVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNA 214

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034654171  81 LADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIRKSGLTPIH 155
Cdd:COG0666   215 KDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 4-286 9.68e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 81.64  E-value: 9.68e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171   4 TLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHcdVLEHlihkggdvlalad 83
Cdd:PHA03100   20 YIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKY--NLTD------------- 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  84 dgasvlfeaagggNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYE--GHYLALKYLIPVTSK-NAIRKSGLTPIHSAADG 160
Cdd:PHA03100   85 -------------VKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANvNIKNSDGENLLHLYLES 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 161 --QNAQCLELLIENGFDVNT------LLADHISQSYDDER-KTALYFGVSNNDVHCTEVLLAAGADPNLDPLN---CLLV 228
Cdd:PHA03100  152 nkIDLKILKLLIDKGVDINAknrvnyLLSYGVPINIKDVYgFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYgdtPLHI 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034654171 229 AVRANNYEIVRLLLSHGANVN---CYFMHVNDTRFPSVIQYAL-NDEVMLRLLLNNGYQVEM 286
Cdd:PHA03100  232 AILNNNKEIFKLLLNNGPSIKtiiETLLYFKDKDLNTITKIKMlKKSIMYMFLLDPGFYKNR 293
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 374-425 6.84e-16

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 71.42  E-value: 6.84e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034654171 374 ENPCSLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKEYDLYGQ 425
Cdd:cd03730     1 TNPRSLKHLCRLKIRACMGRLRLRCPVFMSFLPLPNRLKAYILYKEYDLYGQ 52
Ank_2 pfam12796
Ankyrin repeats (3 copies);
89-178 2.71e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.22  E-value: 2.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  89 LFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNaIRKSGLTPIHSAADGQNAQCLEL 168
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN-LKDNGRTALHYAARSGHLEIVKL 79

                          90
                  ....*....|
gi 1034654171 169 LIENGFDVNT 178
Cdd:pfam12796  80 LLEKGADINV 89
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 374-418 6.01e-14

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 65.59  E-value: 6.01e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1034654171 374 ENPCSLKHLCRLKIRRLMGLQKLCQpasVEKLPLPPAIQRYILFK 418
Cdd:cd03716     1 STPRSLQHLCRLAIRRCLGRRRLEL---IKKLPLPPRLKDYLLYE 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
23-115 2.24e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.52  E-value: 2.24e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  23 MHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLI-HKGGDVlalADDGASVLFEAAGGGNPDCI 101
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLeHADVNL---KDNGRTALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 1034654171 102 SLLLEYGGSGNVPN 115
Cdd:pfam12796  78 KLLLEKGADINVKD 91
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 375-418 1.09e-12

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 62.10  E-value: 1.09e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1034654171 375 NPCSLKHLCRLKIRRLMGLQKLCQpasVEKLPLPPAIQRYILFK 418
Cdd:cd03587     1 NPRSLQHLCRLAIRRCLGKRRLDL---IDKLPLPPRLKDYLLYK 41
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1-179 2.43e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 68.15  E-value: 2.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171   1 MVSTLIKHNTSLDQPCVKRWSAMH----EAAKQGR-KDIVALLLKHGGNVHLRDGFGVTPLGVAA--EYGHCDVLEHLIH 73
Cdd:PHA03100   50 VVKILLDNGADINSSTKNNSTPLHylsnIKYNLTDvKEIVKLLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEYLLD 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  74 KGGDVLALADDGASVLFEAAGGGNPDC------------------ISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALK 135
Cdd:PHA03100  130 NGANVNIKNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVK 209

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1034654171 136 YLIPV-TSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTL 179
Cdd:PHA03100  210 YLLDLgANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTI 254
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 33-179 4.47e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 67.60  E-value: 4.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  33 DIVALLLKHGGNVHLRD-GFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSG 111
Cdd:PHA02878  148 EITKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST 227

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034654171 112 NVPNRAGHLPIHRAA-----YEGHYLALKYLIPVTSKNAIRksGLTPIHSAAdgQNAQCLELLIENGFDVNTL 179
Cdd:PHA02878  228 DARDKCGNTPLHISVgyckdYDILKLLLEHGVDVNAKSYIL--GLTALHSSI--KSERKLKLLLEYGADINSL 296
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 59-257 5.26e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 67.32  E-value: 5.26e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  59 AAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLI 138
Cdd:PHA02875    9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 139 PVTS--KNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNT----------------------LLADHISQS--YDDER 192
Cdd:PHA02875   89 DLGKfaDDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIpntdkfsplhlavmmgdikgieLLIDHKACLdiEDCCG 168

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034654171 193 KTALYFGVSNNDVHCTEVLLAAGADPNLDPLN----CLLVAVRANNYEIVRLLLSHGANVNCYFMHVND 257
Cdd:PHA02875  169 CTPLIIAMAKGDIAICKMLLDSGANIDYFGKNgcvaALCYAIENNKIDIVRLFIKRGADCNIMFMIEGE 237
Ank_2 pfam12796
Ankyrin repeats (3 copies);
122-220 6.33e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.29  E-value: 6.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 122 IHRAAYEGHYLALKYLIPV-TSKNAIRKSGLTPIHSAADGQNAQCLELLIEngfdvntlladHISQSYDDERKTALYFGV 200
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENgADANLQDKNGRTALHLAAKNGHLEIVKLLLE-----------HADVNLKDNGRTALHYAA 69

                          90       100
                  ....*....|....*....|
gi 1034654171 201 SNNDVHCTEVLLAAGADPNL 220
Cdd:pfam12796  70 RSGHLEIVKLLLEKGADINV 89
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 63-284 6.74e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 66.91  E-value: 6.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  63 GHCDVLEHLIHKGGDVLALA-DDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIpvt 141
Cdd:PHA02874   12 GDIEAIEKIIKNKGNCINISvDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLI--- 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 142 sKNAIRKSGLtPIHSAadgqNAQCLELLIENGFDVNTlladhisqsYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLD 221
Cdd:PHA02874   89 -DNGVDTSIL-PIPCI----EKDMIKTILDCGIDVNI---------KDAELKTFLHYAIKKGDLESIKMLFEYGADVNIE 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034654171 222 PLNC---LLVAVRANNYEIVRLLLSHGANVNcyfmhVNDTRFPSVIQYALN--DEVMLRLLLNNGYQV 284
Cdd:PHA02874  154 DDNGcypIHIAIKHNFFDIIKLLLEKGAYAN-----VKDNNGESPLHNAAEygDYACIKLLIDHGNHI 216
Ank_2 pfam12796
Ankyrin repeats (3 copies);
154-249 1.34e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.51  E-value: 1.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 154 IHSAADGQNAQCLELLIENGFDVNTLladhisqsyDDERKTALYFGVSNNDVHCTEVLLA-AGADPNLDPLNCLLVAVRA 232
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQ---------DKNGRTALHLAAKNGHLEIVKLLLEhADVNLKDNGRTALHYAARS 71

                          90
                  ....*....|....*..
gi 1034654171 233 NNYEIVRLLLSHGANVN 249
Cdd:pfam12796  72 GHLEIVKLLLEKGADIN 88
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 375-416 2.26e-11

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 58.33  E-value: 2.26e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034654171 375 NPCSLKHLCRLKIRRLMGLQKLCQpasVEKLPLPPAIQRYIL 416
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGA---IDKLPLPPLLKDYLL 39
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 23-285 2.53e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 65.47  E-value: 2.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  23 MHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCIS 102
Cdd:PHA02876  149 IKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIK 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 103 LLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIRKsglTPIHSAADGQN-AQCLELLIENGFDVNtllA 181
Cdd:PHA02876  229 AIIDNRSNINKNDLSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKN---TPLHHASQAPSlSRLVPKLLERGADVN---A 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 182 DHIsqsyddERKTALYFGVSNN-DVHCTEVLLAAGADPN------LDPLNclLVAVRANNYEIVRLLLSHGANVNcyfmh 254
Cdd:PHA02876  303 KNI------KGETPLYLMAKNGyDTENIRTLIMLGADVNaadrlyITPLH--QASTLDRNKDIVITLLELGANVN----- 369

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1034654171 255 VNDTRFPSVIQYAL--NDEVMLRLLLNNGYQVE 285
Cdd:PHA02876  370 ARDYCDKTPIHYAAvrNNVVIINTLLDYGADIE 402
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 32-172 3.74e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.60  E-value: 3.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  32 KDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSG 111
Cdd:PHA02874  104 KDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYA 183

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034654171 112 NVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIR-KSGLTPIHSAADgQNAQCLELLIEN 172
Cdd:PHA02874  184 NVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKcKNGFTPLHNAII-HNRSAIELLINN 244
PHA03095 PHA03095
ankyrin-like protein; Provisional
 33-248 9.77e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 63.51  E-value: 9.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  33 DIVALLLKHGGNVHLRDGFGVTPLGVaaeyghcdvlehLIHKGGDVLaladdgasvlfeaagggnPDCISLLLEYGGSGN 112
Cdd:PHA03095   28 EEVRRLLAAGADVNFRGEYGKTPLHL------------YLHYSSEKV------------------KDIVRLLLEAGADVN 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 113 VPNRAGHLPIHraayegHYLALKYLIPVtsknairksgltpihsaadgqnaqcLELLIENGFDVNtlladhisqSYDDER 192
Cdd:PHA03095   78 APERCGFTPLH------LYLYNATTLDV-------------------------IKLLIKAGADVN---------AKDKVG 117

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034654171 193 KTAL--YFGVSNNDVHCTEVLLAAGADPN------LDPLNCLLVAVRAnNYEIVRLLLSHGANV 248
Cdd:PHA03095  118 RTPLhvYLSGFNINPKVIRLLLRKGADVNaldlygMTPLAVLLKSRNA-NVELLRLLIDAGADV 180
PHA03095 PHA03095
ankyrin-like protein; Provisional
 31-243 1.13e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 63.12  E-value: 1.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  31 RKDIVALLLKHGGNVHLRDGFGVTPLgvaaeygHC--------DVLEHLIHKGGDVLALADDGASVLFEAAGGGN--PDC 100
Cdd:PHA03095   62 VKDIVRLLLEAGADVNAPERCGFTPL-------HLylynattlDVIKLLIKAGADVNAKDKVGRTPLHVYLSGFNinPKV 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 101 ISLLLEYGGSGNVPNRAGHLPIH------RAAYEghylALKYLI----PVTSKNAIRKS--------------------- 149
Cdd:PHA03095  135 IRLLLRKGADVNALDLYGMTPLAvllksrNANVE----LLRLLIdagaDVYAVDDRFRSllhhhlqsfkprarivrelir 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 150 -----------GLTPIHSAADGQNAQCLEL--LIENGFDVNTLladhisqsyDDERKTALYFG-VSNNDVHCtEVLLAAG 215
Cdd:PHA03095  211 agcdpaatdmlGNTPLHSMATGSSCKRSLVlpLLIAGISINAR---------NRYGQTPLHYAaVFNNPRAC-RRLIALG 280

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1034654171 216 ADPNL---DPLNCLLVAVRANNYEIVRLLLS 243
Cdd:PHA03095  281 ADINAvssDGNTPLSLMVRNNNGRAVRAALA 311
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1-78 2.58e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.66  E-value: 2.58e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034654171   1 MVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHgGNVHLRDgFGVTPLGVAAEYGHCDVLEHLIHKGGDV 78
Cdd:pfam12796  12 LVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADI 87
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1-113 1.28e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 59.62  E-value: 1.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171   1 MVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLA 80
Cdd:PHA02875  117 IMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDY 196

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1034654171  81 LADDG-ASVLFEAAGGGNPDCISLLLEYGGSGNV 113
Cdd:PHA02875  197 FGKNGcVAALCYAIENNKIDIVRLFIKRGADCNI 230
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 21-138 6.43e-09

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 57.96  E-value: 6.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  21 SAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHkggdvLALADD---GASVLFEAAGGGN 97
Cdd:PLN03192  560 TPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYH-----FASISDphaAGDLLCTAAKRND 634

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1034654171  98 PDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLI 138
Cdd:PLN03192  635 LTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 377-418 1.55e-08

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 50.10  E-value: 1.55e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1034654171  377 CSLKHLCRLKIRRLMGLqklcqpasVEKLPLPPAIQRYILFK 418
Cdd:smart00969   1 RSLQHLCRLAIRRSLGG--------IDKLPLPPRLKDYLLYY 34
Ank_4 pfam13637
Ankyrin repeats (many copies);
19-72 4.65e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.20  E-value: 4.65e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034654171  19 RWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLI 72
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 89-284 2.06e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.96  E-value: 2.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  89 LFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPVTSKNAIRKSgLTPIHSAADGQNAQCLEL 168
Cdd:PHA02878   41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYT-LVAIKDAFNNRNVEIFKI 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 169 LIENGFDVN----------------------TLLADH---ISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLdPL 223
Cdd:PHA02878  120 ILTNRYKNIqtidlvyidkkskddiieaeitKLLLSYgadINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNI-PD 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034654171 224 NC----LLVAVRANNYEIVRLLLSHGANVNCYFMHVNdTRFPSVIQYALNDEVmLRLLLNNGYQV 284
Cdd:PHA02878  199 KTnnspLHHAVKHYNKPIVHILLENGASTDARDKCGN-TPLHISVGYCKDYDI-LKLLLEHGVDV 261
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 374-418 2.84e-07

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 46.94  E-value: 2.84e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1034654171 374 ENPCSLKHLCRLKIRRLMGLQKLCQpasVEKLPLPPAIQRYILFK 418
Cdd:cd03719     1 AEPHSLLHLSRLCVRHALGDTRLGQ---VSALPLPPAMKRYLLYQ 42
SOCS_ASB8 cd03727
SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a ...
 376-418 7.43e-07

SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239697  Cd Length: 43  Bit Score: 45.60  E-value: 7.43e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1034654171 376 PCSLKHLCRLKIRRLMGLQKLcqPASVEKLPLPPAIQRYILFK 418
Cdd:cd03727     3 PGTLKALARYAVRRSLGVQYL--PEAVKQLPLPRSVKEYLLLL 43
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 21-179 8.44e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 51.22  E-value: 8.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  21 SAMHEAAKQGR-KDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPd 99
Cdd:PHA02876  343 TPLHQASTLDRnKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNP- 421

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 100 cisllleyggsgnvpnraghlpihraayeghYLALKYLIP----VTSKNairKSGLTPIHSAADGQ-NAQCLELLIENGF 174
Cdd:PHA02876  422 -------------------------------YMSVKTLIDrganVNSKN---KDLSTPLHYACKKNcKLDVIEMLLDNGA 467


                  ....*
gi 1034654171 175 DVNTL 179
Cdd:PHA02876  468 DVNAI 472
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 374-416 1.07e-06

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 44.98  E-value: 1.07e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1034654171  374 ENPCSLKHLCRLKIRRLMGLQklcqpaSVEKLPLPPAIQRYIL 416
Cdd:smart00253   5 SNVPSLQHLCRFTIRRCTRTD------QIKTLPLPPKLKDYLS 41
Ank_4 pfam13637
Ankyrin repeats (many copies);
87-138 1.39e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.96  E-value: 1.39e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034654171  87 SVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLI 138
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 21-125 1.52e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 50.26  E-value: 1.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  21 SAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAeyGHC---DVLEHLIHKGGDVLALAD-DGASVLFEAAggG 96
Cdd:PHA02878  203 SPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV--GYCkdyDILKLLLEHGVDVNAKSYiLGLTALHSSI--K 278

                          90       100
                  ....*....|....*....|....*....
gi 1034654171  97 NPDCISLLLEYGGSGNVPNRAGHLPIHRA 125
Cdd:PHA02878  279 SERKLKLLLEYGADINSLNSYKLTPLSSA 307
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 376-418 2.41e-06

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 44.22  E-value: 2.41e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1034654171 376 PCSLKHLCRLKIRRLMGLQKLcqpASVEKLPLPPAIQRYILFK 418
Cdd:cd03718     3 PLPLMDLCRRRVRVALGRDRL---EEIEQLPLPPSLKNYLLYQ 42
SOCS_ASB3 cd03722
SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a ...
 378-419 4.18e-06

SOCS (suppressors of cytokine signaling) box of ASB3-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ABS3 has been shown to be negative regulator of TNF-R2-mediated cellular responses to TNF-alpha by direct targeting of tumor necrosis factor receptor II (TNF-R2) for ubiquitination and proteasome-mediated degradation. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239692  Cd Length: 51  Bit Score: 43.63  E-value: 4.18e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034654171 378 SLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKE 419
Cdd:cd03722     5 SLTHLCRLEIRSSLKSERLRSDSFICQLPLPRSLQDYLLYSD 46
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 21-284 5.15e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 48.91  E-value: 5.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  21 SAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDV-------------------LAL 81
Cdd:PHA02876  180 TPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNInkndlsllkairnedletsLLL 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  82 ADDGASV----------LFEAAGGGN-PDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLA-LKYLIPVTSK-NAIRK 148
Cdd:PHA02876  260 YDAGFSVnsiddckntpLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYDTEnIRTLIMLGADvNAADR 339

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 149 SGLTPIHSAAD-GQNAQCLELLIENGFDVNtlladhiSQSYDDerKTALYFGVSNNDVHCTEVLLAAGADpnLDPLN--- 224
Cdd:PHA02876  340 LYITPLHQASTlDRNKDIVITLLELGANVN-------ARDYCD--KTPIHYAAVRNNVVIINTLLDYGAD--IEALSqki 408

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034654171 225 --CLLVAVRANN-YEIVRLLLSHGANVNCyfmhvNDTRFPSVIQYALNDEV---MLRLLLNNGYQV 284
Cdd:PHA02876  409 gtALHFALCGTNpYMSVKTLIDRGANVNS-----KNKDLSTPLHYACKKNCkldVIEMLLDNGADV 469
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 374-419 5.32e-06

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 43.32  E-value: 5.32e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1034654171 374 ENPCSLKHLCRLKIRRLMGLQKLcqpASVEKLPLPPAIQRYILFKE 419
Cdd:cd03721     1 EPPRPLAHLCRLKVRTLIGINRI---KLIDTLPLPPRLIRYLNHQE 43
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 375-416 9.87e-06

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 42.41  E-value: 9.87e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034654171 375 NPCSLKHLCRLKIRRLMGLQKLcqpASVEKLPLPPAIQRYIL 416
Cdd:cd03720     2 NPRSLLSLCRIAVRRALGKQRL---SLICSLPLPDPIKKFLL 40
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 375-416 1.09e-05

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 42.43  E-value: 1.09e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034654171 375 NPCSLKHLCRLKIRRLMGlqKLCQpASVEKLPLPPAIQRYIL 416
Cdd:cd03723     2 TPRSLQHLCRCAIRKLLG--SRCH-KLVPQLSLPTSLKNYLL 40
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 378-418 1.26e-05

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 42.11  E-value: 1.26e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034654171 378 SLKHLCRLKIRRLMGLQKlcqpasVEKLPLPPAIQRYILFK 418
Cdd:cd03746     5 SLQHLCRMAIRRVMPTQQ------VKELPIPSKLLEFLTYR 39
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 85-249 1.90e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 47.00  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  85 GASVLFEAAGGGNP-DCISLLLEYGGSGNVpnraGHLPIHRAA---YEGHYLALKYLIPVTSK-------NAIRKS---- 149
Cdd:TIGR00870  52 GRSALFVAAIENENlELTELLLNLSCRGAV----GDTLLHAISleyVDAVEAILLHLLAAFRKsgplelaNDQYTSeftp 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 150 GLTPIHSAADGQNAQCLELLIENGFDVN---TLLADHISQsyddeRKTALYFGVSnndvhctevllaagadpnldPLN-- 224
Cdd:TIGR00870 128 GITALHLAAHRQNYEIVKLLLERGASVParaCGDFFVKSQ-----GVDSFYHGES--------------------PLNaa 182

                         170       180
                  ....*....|....*....|....*.
gi 1034654171 225 -CLlvavraNNYEIVRLLLSHGANVN 249
Cdd:TIGR00870 183 aCL------GSPSIVALLSEDPADIL 202
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 378-418 2.47e-05

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 41.25  E-value: 2.47e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034654171 378 SLKHLCRLKIRRLMGLQKlcqpasVEKLPLPPAIQRYILFK 418
Cdd:cd03733     5 SLQHLCRMALRRVMTTQQ------VLALPIPKKMKEFLTYR 39
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 378-420 3.15e-05

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 40.66  E-value: 3.15e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1034654171 378 SLKHLCRLKIRRLMGLQKlcqpasVEKLPLPPAIQRYIlfKEY 420
Cdd:cd03717     5 SLQHLCRFVIRQCTRRDL------IDQLPLPRRLKDYL--KEY 39
Ank_4 pfam13637
Ankyrin repeats (many copies);
150-212 1.34e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 1.34e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034654171 150 GLTPIHSAADGQNAQCLELLIENGFDVNTLladhisqsyDDERKTALYFGVSNNDVHCTEVLL 212
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAV---------DGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 25-78 1.51e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.09  E-value: 1.51e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034654171  25 EAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDV 78
Cdd:PLN03192  628 TAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681
Ank_4 pfam13637
Ankyrin repeats (many copies);
121-170 1.56e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 1.56e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034654171 121 PIHRAAYEGHYLALKYLIPVTSK-NAIRKSGLTPIHSAADGQNAQCLELLI 170
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADiNAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
52-105 1.81e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 1.81e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034654171  52 GVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLL 105
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 166-249 1.86e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 43.58  E-value: 1.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 166 LELLIENGFDVN------TLLADHISQSYDDERKTAlyfgvsnndvHCTEVLLAAGADPNLDPLN------CLLVAVRAN 233
Cdd:PHA02989   53 VKLLIDNGADVNykgyieTPLCAVLRNREITSNKIK----------KIVKLLLKFGADINLKTFNgvspivCFIYNSNIN 122

                          90
                  ....*....|....*.
gi 1034654171 234 NYEIVRLLLSHGANVN 249
Cdd:PHA02989  123 NCDMLRFLLSKGINVN 138
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 87-248 4.01e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.69  E-value: 4.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  87 SVLFEAAGGGNPDCISLLLEYGgSGNVPNRA--GHLPIHRAAYEGHYLALKYLI---PVTSKNAIRKS---GLTPIHSAA 158
Cdd:cd22192    19 SPLLLAAKENDVQAIKKLLKCP-SCDLFQRGalGETALHVAALYDNLEAAVVLMeaaPELVNEPMTSDlyqGETALHIAV 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 159 DGQNAQCLELLIENGFDVNTlladhisqsyddERKTALYFGVSNndvHCtevLLAAGADPnldplncLLVAVRANNYEIV 238
Cdd:cd22192    98 VNQNLNLVRELIARGADVVS------------PRATGTFFRPGP---KN---LIYYGEHP-------LSFAACVGNEEIV 152

                         170
                  ....*....|
gi 1034654171 239 RLLLSHGANV 248
Cdd:cd22192   153 RLLIEHGADI 162
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1-49 5.47e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 38.94  E-value: 5.47e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1034654171   1 MVSTLIKHNTSLDQpcVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRD 49
Cdd:pfam12796  45 IVKLLLEHADVNLK--DNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_5 pfam13857
Ankyrin repeats (many copies);
38-89 6.35e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.71  E-value: 6.35e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034654171  38 LLKHGG-NVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVL 89
Cdd:pfam13857   1 LLEHGPiDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 224-250 1.11e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 1.11e-03
                           10        20
                   ....*....|....*....|....*..
gi 1034654171  224 NCLLVAVRANNYEIVRLLLSHGANVNC 250
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADINA 30
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 26-176 1.21e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 41.39  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171  26 AAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLL 105
Cdd:PLN03192  532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034654171 106 EYGGSGNvPNRAGHLpIHRAAYEGHYLALKYLIP----VTSKNairKSGLTPIHSAADGQNAQCLELLIENGFDV 176
Cdd:PLN03192  612 HFASISD-PHAAGDL-LCTAAKRNDLTAMKELLKqglnVDSED---HQGATALQVAMAEDHVDMVRLLIMNGADV 681
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 166-284 1.26e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 40.88  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 166 LELLIENGFDVNTlladhisqSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLD-----PLNCLLvavraNNYEI--- 237
Cdd:PHA02989   19 LEFLLRTGFDVNE--------EYRGNSILLLYLKRKDVKIKIVKLLIDNGADVNYKgyietPLCAVL-----RNREItsn 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034654171 238 -----VRLLLSHGANVNCYFMHVNDTRFPSVIQYALNDEVMLRLLLNNGYQV 284
Cdd:PHA02989   86 kikkiVKLLLKFGADINLKTFNGVSPIVCFIYNSNINNCDMLRFLLSKGINV 137
SOCS_CIS1 cd03734
SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like ...
 378-420 2.69e-03

SOCS (suppressors of cytokine signaling) box of CIS (cytokine-inducible SH2 protein) 1-like proteins. Together with the SOCS proteins, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. CIS1, like SOCS1 and SOCS3, is involved in the down-regulation of the JAK/STAT pathway. CIS1 binds to cytokine receptors at STAT5-docking sites, which prohibits recruitment of STAT5 to the receptor signaling complex and results in the down-regulation of activation by STAT5.


Pssm-ID: 239703  Cd Length: 41  Bit Score: 35.32  E-value: 2.69e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1034654171 378 SLKHLCRLKIRRLMglqklcqpASVEKLPLPPAIQRYIlfKEY 420
Cdd:cd03734     5 SLQHLCRLVINRLV--------TDVDCLPLPRRMADYL--RQY 37
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 376-418 3.44e-03

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 35.34  E-value: 3.44e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1034654171 376 PCSLKHLCRLKIRRLMGLQKLCQpasVEKLPLPPAIQRYILFK 418
Cdd:cd03744     3 PLPLMDLCRRSVRLALGRERLSE---IHTLPLPASLKNYLLYQ 42
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 155-244 3.86e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.50  E-value: 3.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 155 HSAADGqNAQCLELLIENGFDVNtlladhiSQSYDDerKTALYFGVSNNDVHCTEVLLAAGADPNL---DPLNCLLVAVR 231
Cdd:PTZ00322   88 QLAASG-DAVGARILLTGGADPN-------CRDYDG--RTPLHIACANGHVQVVRVLLEFGADPTLldkDGKTPLELAEE 157

                          90
                  ....*....|...
gi 1034654171 232 ANNYEIVRLLLSH 244
Cdd:PTZ00322  158 NGFREVVQLLSRH 170
PHA02730 PHA02730
ankyrin-like protein; Provisional
 164-269 3.97e-03

ankyrin-like protein; Provisional


Pssm-ID: 165098 [Multi-domain]  Cd Length: 672  Bit Score: 39.62  E-value: 3.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654171 164 QCLELLIENGFDVNTLLADHISQsYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAV------RANNYEI 237
Cdd:PHA02730  435 HCYETILIDVFDILSKYMDDIDM-IDNENKTLLYYAVDVNNIQFARRLLEYGASVNTTSRSIINTAIqkssyrRENKTKL 513

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034654171 238 VRLLLSH---------GANVNCYFMH------------VNDTRFPSVIQYALN 269
Cdd:PHA02730  514 VDLLLSYhptletmidAFNRDIRYLYpepllaciryalILDNDFPSKVKYDIA 566
Ank_5 pfam13857
Ankyrin repeats (many copies);
5-59 4.43e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.40  E-value: 4.43e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034654171   5 LIKHNT-SLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVA 59
Cdd:pfam13857   1 LLEHGPiDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 35-107 6.95e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 38.73  E-value: 6.95e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034654171  35 VALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEY 107
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 31-106 7.39e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 38.57  E-value: 7.39e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034654171  31 RKDIVAL--LLKHGgNVHLRDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLE 106
Cdd:PHA02989  234 KKEFKVLnfILKYI-KINKKDKKGFNPLLISAKVDNYEAFNYLLKLGDDIYNVSKDGDTVLTYAIKHGNIDMLNRILQ 310
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 219-289 8.03e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 38.49  E-value: 8.03e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034654171 219 NLDPLNCLLVAVRANNYEIVRLLLSHGANVNCYFM-HVNDTRFPSVIQYALNDEV-MLRLLLNNGYQVEMCFD 289
Cdd:PHA03100   32 YKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKnNSTPLHYLSNIKYNLTDVKeIVKLLLEYGANVNAPDN 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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