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Conserved domains on  [gi|1034651932|ref|XP_016866867|]
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R-spondin-3 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Furin-like_2 super family cl25785
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ...
 42-142 3.23e-50

Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.


The actual alignment was detected with superfamily member pfam15913:

Pssm-ID: 464939 [Multi-domain]  Cd Length: 102  Bit Score: 158.75  E-value: 3.23e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651932  42 QGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKA-DCDTCFNKNFCTKCKSGFYL 120
Cdd:pfam15913   1 CSGCVLCSEENGCLTCQPRLFLLLERNGIRQYGVCLHSCPPGYFGIRGQEVNRCTKCKAeNCESCFSKDFCTKCKEGFYL 80

                          90       100
                  ....*....|....*....|..
gi 1034651932 121 HLGKCLDNCPEGLEANNHTMEC 142
Cdd:pfam15913  81 HKGKCLDTCPEGTAAQNSTMEC 102
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 148-203 1.26e-11

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


:

Pssm-ID: 465948  Cd Length: 52  Bit Score: 57.67  E-value: 1.26e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034651932 148 CEVSEWNPWSPCTKkgkTCGfkRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQR 203
Cdd:pfam19028   1 CVVSEWSEWSECSV---TCG--GGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPP 51
 
Name Accession Description Interval E-value
Furin-like_2 pfam15913
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ...
 42-142 3.23e-50

Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.


Pssm-ID: 464939 [Multi-domain]  Cd Length: 102  Bit Score: 158.75  E-value: 3.23e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651932  42 QGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKA-DCDTCFNKNFCTKCKSGFYL 120
Cdd:pfam15913   1 CSGCVLCSEENGCLTCQPRLFLLLERNGIRQYGVCLHSCPPGYFGIRGQEVNRCTKCKAeNCESCFSKDFCTKCKEGFYL 80

                          90       100
                  ....*....|....*....|..
gi 1034651932 121 HLGKCLDNCPEGLEANNHTMEC 142
Cdd:pfam15913  81 HKGKCLDTCPEGTAAQNSTMEC 102
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 148-203 1.26e-11

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 57.67  E-value: 1.26e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034651932 148 CEVSEWNPWSPCTKkgkTCGfkRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQR 203
Cdd:pfam19028   1 CVVSEWSEWSECSV---TCG--GGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPP 51
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 97-143 1.40e-04

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 38.27  E-value: 1.40e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1034651932  97 KCKADCDTCFNK--NFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECV 143
Cdd:cd00064     1 PCHPSCATCTGPgpDQCTSCRHGFYLDGGTCVSECPEGTYADTEGGVCL 49
FU smart00261
Furin-like repeats;
93-132 3.07e-04

Furin-like repeats;


Pssm-ID: 214589 [Multi-domain]  Cd Length: 45  Bit Score: 37.49  E-value: 3.07e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1034651932   93 NKCTKCKADCDTCFNK--NFCTKCKSGFYLHLGKCLDNCPEG 132
Cdd:smart00261   2 GECKPCHPECATCTGPgpDDCTSCKHGFFLDGGKCVSECPPG 43
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 150-202 5.98e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 34.10  E-value: 5.98e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1034651932  150 VSEWNPWSPCTkkgKTCGfkRGTETRVREIIQHP-SAKGNLCP-PTNETRKCTVQ 202
Cdd:smart00209   1 WSEWSEWSPCS---VTCG--GGVQTRTRSCCSPPpQNGGGPCTgEDVETRACNEQ 50
 
Name Accession Description Interval E-value
Furin-like_2 pfam15913
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ...
 42-142 3.23e-50

Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.


Pssm-ID: 464939 [Multi-domain]  Cd Length: 102  Bit Score: 158.75  E-value: 3.23e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651932  42 QGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKA-DCDTCFNKNFCTKCKSGFYL 120
Cdd:pfam15913   1 CSGCVLCSEENGCLTCQPRLFLLLERNGIRQYGVCLHSCPPGYFGIRGQEVNRCTKCKAeNCESCFSKDFCTKCKEGFYL 80

                          90       100
                  ....*....|....*....|..
gi 1034651932 121 HLGKCLDNCPEGLEANNHTMEC 142
Cdd:pfam15913  81 HKGKCLDTCPEGTAAQNSTMEC 102
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 148-203 1.26e-11

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 57.67  E-value: 1.26e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034651932 148 CEVSEWNPWSPCTKkgkTCGfkRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQR 203
Cdd:pfam19028   1 CVVSEWSEWSECSV---TCG--GGVQTRTRTVIVEPQNGGRPCPELLERRPCNLPP 51
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 97-143 1.40e-04

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 38.27  E-value: 1.40e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1034651932  97 KCKADCDTCFNK--NFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECV 143
Cdd:cd00064     1 PCHPSCATCTGPgpDQCTSCRHGFYLDGGTCVSECPEGTYADTEGGVCL 49
FU smart00261
Furin-like repeats;
93-132 3.07e-04

Furin-like repeats;


Pssm-ID: 214589 [Multi-domain]  Cd Length: 45  Bit Score: 37.49  E-value: 3.07e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1034651932   93 NKCTKCKADCDTCFNK--NFCTKCKSGFYLHLGKCLDNCPEG 132
Cdd:smart00261   2 GECKPCHPECATCTGPgpDDCTSCKHGFFLDGGKCVSECPPG 43
TSP_1 pfam00090
Thrombospondin type 1 domain;
151-202 2.40e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 35.09  E-value: 2.40e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034651932 151 SEWNPWSPCTkkgKTCGfkRGTETRVReIIQHPSAKGNLCP-PTNETRKCTVQ 202
Cdd:pfam00090   1 SPWSPWSPCS---VTCG--KGIQVRQR-TCKSPFPGGEPCTgDDIETQACKMD 47
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 150-202 5.98e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 34.10  E-value: 5.98e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1034651932  150 VSEWNPWSPCTkkgKTCGfkRGTETRVREIIQHP-SAKGNLCP-PTNETRKCTVQ 202
Cdd:smart00209   1 WSEWSEWSPCS---VTCG--GGVQTRTRSCCSPPpQNGGGPCTgEDVETRACNEQ 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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