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Conserved domains on  [gi|1034651893|ref|XP_016866857|]
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tau-tubulin kinase 1 isoform X7 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 410-703 1.87e-05

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.24  E-value: 1.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893  410 SALSGAPRETPSEMATNSLPNGPALADGPAPVSPLEPSPEKVATISPRRHAMPGSRPRSRIpvllsEEDTGSEPSGSLSA 489
Cdd:PHA03307   152 PPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSP-----ISASASSPAPAPGR 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893  490 KERWSKRARPQQDLARLVMEKRQGrlllrlaSGASSSSSEEQRRASETLSGTGSEEDTPASEPAAALPRKSGRAAATRSR 569
Cdd:PHA03307   227 SAADDAGASSSDSSSSESSGCGWG-------PENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPS 299

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893  570 IPRPIGLRMPMPVAAQQPASRSHGAAPALDTAITSSRLQLQTPPGSATAADLRPKQPPGRGLGPGRAQAGARPPAPRSPR 649
Cdd:PHA03307   300 PSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPA 379

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034651893  650 LPASTSAARNASASPRSQSLsRRESPSPSHQARPGVPPPRGVPPARA----QPDGTPS 703
Cdd:PHA03307   380 ASAGRPTRRRARAAVAGRAR-RRDATGRFPAGRPRPSPLDAGAASGAfyarYPLLTPS 436
 
Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 410-703 1.87e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.24  E-value: 1.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893  410 SALSGAPRETPSEMATNSLPNGPALADGPAPVSPLEPSPEKVATISPRRHAMPGSRPRSRIpvllsEEDTGSEPSGSLSA 489
Cdd:PHA03307   152 PPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSP-----ISASASSPAPAPGR 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893  490 KERWSKRARPQQDLARLVMEKRQGrlllrlaSGASSSSSEEQRRASETLSGTGSEEDTPASEPAAALPRKSGRAAATRSR 569
Cdd:PHA03307   227 SAADDAGASSSDSSSSESSGCGWG-------PENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPS 299

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893  570 IPRPIGLRMPMPVAAQQPASRSHGAAPALDTAITSSRLQLQTPPGSATAADLRPKQPPGRGLGPGRAQAGARPPAPRSPR 649
Cdd:PHA03307   300 PSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPA 379

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034651893  650 LPASTSAARNASASPRSQSLsRRESPSPSHQARPGVPPPRGVPPARA----QPDGTPS 703
Cdd:PHA03307   380 ASAGRPTRRRARAAVAGRAR-RRDATGRFPAGRPRPSPLDAGAASGAfyarYPLLTPS 436
 
Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 410-703 1.87e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.24  E-value: 1.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893  410 SALSGAPRETPSEMATNSLPNGPALADGPAPVSPLEPSPEKVATISPRRHAMPGSRPRSRIpvllsEEDTGSEPSGSLSA 489
Cdd:PHA03307   152 PPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSP-----ISASASSPAPAPGR 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893  490 KERWSKRARPQQDLARLVMEKRQGrlllrlaSGASSSSSEEQRRASETLSGTGSEEDTPASEPAAALPRKSGRAAATRSR 569
Cdd:PHA03307   227 SAADDAGASSSDSSSSESSGCGWG-------PENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPS 299

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893  570 IPRPIGLRMPMPVAAQQPASRSHGAAPALDTAITSSRLQLQTPPGSATAADLRPKQPPGRGLGPGRAQAGARPPAPRSPR 649
Cdd:PHA03307   300 PSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPA 379

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034651893  650 LPASTSAARNASASPRSQSLsRRESPSPSHQARPGVPPPRGVPPARA----QPDGTPS 703
Cdd:PHA03307   380 ASAGRPTRRRARAAVAGRAR-RRDATGRFPAGRPRPSPLDAGAASGAfyarYPLLTPS 436
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
396-677 2.37e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 47.92  E-value: 2.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893 396 GLALSGLNGAEIEGSALSGAPRETPSEMATNSLPNGPALADGPAPVSPlepspekvATISPRRHAMPGSRPRSRIPVLLS 475
Cdd:PRK07003  365 GGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAP--------KAAAAAAATRAEAPPAAPAPPATA 436

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893 476 EEDTGSEPSGSLSAkerwSKRARPQQDLARLVMEKRQGRLLLRLASGASSSSSEEQRRASETLSGTGSEEDTPASEPAAA 555
Cdd:PRK07003  437 DRGDDAADGDAPVP----AKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARA 512

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893 556 LPRKSGRAAATRSRIPRPiGLRMPMPvAAQQPASRSHGAAPALDTaITSSRLQLQTPPGSATAADLRPKQPPgrglgpgr 635
Cdd:PRK07003  513 PAAASREDAPAAAAPPAP-EARPPTP-AAAAPAARAGGAAAALDV-LRNAGMRVSSDRGARAAAAAKPAAAP-------- 581

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1034651893 636 aqAGARPPAPR-------SPRLPASTSAARNASASPRSQSLSRRESPSP 677
Cdd:PRK07003  582 --AAAPKPAAPrvavqvpTPRARAATGDAPPNGAARAEQAAESRGAPPP 628
PHA03247 PHA03247
large tegument protein UL36; Provisional
 424-711 1.28e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 1.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893  424 ATNSLPNGPALADGPAPVSPLEPSPEKVATisPRRHAMPGSRPRSRIPVLLSEEDTGSEPSGSLSAKERW-------SKR 496
Cdd:PHA03247  2634 AANEPDPHPPPTVPPPERPRDDPAPGRVSR--PRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPppppptpEPA 2711

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893  497 ARPQQDLARLVMEKRQGRLLLRLASGASSSSSEEQRRASETLSGTGSEEDTPASEPAAALPRksGRAAATRSRIPRPIGL 576
Cdd:PHA03247  2712 PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPA--APAAGPPRRLTRPAVA 2789

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893  577 R-------MPMPVAAQQPASRSHGAAPALDTAITSSRLqLQTPPGSATAADLRPKQPP------GRGLGPG-----RAQA 638
Cdd:PHA03247  2790 SlsesresLPSPWDPADPPAAVLAPAAALPPAASPAGP-LPPPTSAQPTAPPPPPGPPppslplGGSVAPGgdvrrRPPS 2868

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034651893  639 GARPPAPRSPRLPASTSAARNA-SASPRSQSLSRRESPSPSHQARPGVPPPRGVPPARAQPDGTPSPGGSKKGP 711
Cdd:PHA03247  2869 RSPAAKPAAPARPPVRRLARPAvSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942
PHA03247 PHA03247
large tegument protein UL36; Provisional
 415-721 1.33e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 1.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893  415 APRetPSEMATNSLPNGPALADGPA-PVSPLEPSPEKVATISPRRHAMPGSRPRsriPVLLSEEDTGSEPSGSLSAKERW 493
Cdd:PHA03247  2574 APR--PSEPAVTSRARRPDAPPQSArPRAPVDDRGDPRGPAPPSPLPPDTHAPD---PPPPSPSPAANEPDPHPPPTVPP 2648

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893  494 SKRARPQQDLARlVMEKRQGRLLLRLASGASSSSSEEQRRASETLSGTGSEEDTPASEPAAAlPRKSGRAAATRSRiPRP 573
Cdd:PHA03247  2649 PERPRDDPAPGR-VSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPE-PAPHALVSATPLP-PGP 2725

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893  574 IGLRMPMPVAAQQPASRSHGAAPALDTAIT--SSRLQLQTPPGSATAADlRPKQPPGRGLGPGRAQAGARPPAPRSPRLP 651
Cdd:PHA03247  2726 AAARQASPALPAAPAPPAVPAGPATPGGPArpARPPTTAGPPAPAPPAA-PAAGPPRRLTRPAVASLSESRESLPSPWDP 2804

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034651893  652 ASTSAARNA--SASPRSQSLSRRESPSPSHQARPGVPPPRGVPPARAqPDGTPSPGG--SKKGPRGKLQAQRAT 721
Cdd:PHA03247  2805 ADPPAAVLApaAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP-LGGSVAPGGdvRRRPPSRSPAAKPAA 2877
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
549-708 1.79e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.76  E-value: 1.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893 549 ASEPAAAlprkSGRAAATRSRIPRPIGLRMPMPVAAQQPASRSHGAAPALDTAITSSrlqlqTPPGSATAADLRPKQPPG 628
Cdd:PRK07003  357 AFEPAVT----GGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAA-----LAPKAAAAAAATRAEAPP 427

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893 629 RglGPGRAQAGARPPAPRSPRLPASTSAARNASASPRSQSLSRRESPSPSHQARPGVPPPRGVPPARAQPDGTPSPGGSK 708
Cdd:PRK07003  428 A--APAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPA 505
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
554-705 2.82e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893 554 AALPRKSGRAAATRSRIPRPIGLRMPmPVAAQQPASRSHGAAPALDTAITSSRLQLQTPPGSATAADLRPKQPPGRGLGP 633
Cdd:PRK12323  362 AFRPGQSGGGAGPATAAAAPVAQPAP-AAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQAS 440

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034651893 634 GRAQAGARPPAPRSPRLPAStsAARNASASPRSQSLSRRESPSPSHQARPGVPPPRGVPPARAQPDGTPSPG 705
Cdd:PRK12323  441 ARGPGGAPAPAPAPAAAPAA--AARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPA 510
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
546-703 4.21e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 4.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893 546 DTPASEPAAALPRKSGRAAATRSRIPRPIGLRMPMPVAAQQPASrshGAAPALDTAITSSRLQLQTPPGSATAADLRPKQ 625
Cdd:PRK12323  417 RAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAA---AARPAAAGPRPVAAAAAAAPARAAPAAAPAPAD 493

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893 626 ---PPGRGLGPGRAQAGARPPAPrSPRLPASTSAARNASASPRSQSLSRRESP--SPSHQARPGVPPPRGVPPARAQPDG 700
Cdd:PRK12323  494 ddpPPWEELPPEFASPAPAQPDA-APAGWVAESIPDPATADPDDAFETLAPAPaaAPAPRAAAATEPVVAPRPPRASASG 572


                  ...
gi 1034651893 701 TPS 703
Cdd:PRK12323  573 LPD 575
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 532-711 4.67e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 4.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893 532 RRASETLSGTGSEEDTPASEPAAALPrkSGRAAATRSRIPRPIGLRMPMPVAAQQPASRSHGAAPALDTAITSSRLQLQT 611
Cdd:PRK07764  599 GPPAPASSGPPEEAARPAAPAAPAAP--AAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGA 676

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893 612 PPGSATAADLRPKQPPGRGLGPGRAQAG--ARPPAPRSPRLPASTSAARNASASPrsQSLSRRESPSPSHQARPGVPPPR 689
Cdd:PRK07764  677 APAAPPPAPAPAAPAAPAGAAPAQPAPApaATPPAGQADDPAAQPPQAAQGASAP--SPAADDPVPLPPEPDDPPDPAGA 754

                         170       180
                  ....*....|....*....|..
gi 1034651893 690 GVPPARAQPDGTPSPGGSKKGP 711
Cdd:PRK07764  755 PAQPPPPPAPAPAAAPAAAPPP 776
PHA03247 PHA03247
large tegument protein UL36; Provisional
 541-718 5.82e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 5.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893  541 TGSEEDTPASEPAAALPRKSGRAAATRSRIPRPiglRMPMPVAAQQPASRSHGAAPALDTAITSSRLqLQTPPGSATAAD 620
Cdd:PHA03247  2764 AGPPAPAPPAAPAAGPPRRLTRPAVASLSESRE---SLPSPWDPADPPAAVLAPAAALPPAASPAGP-LPPPTSAQPTAP 2839

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893  621 LRPKQPP------GRGLGPG-----RAQAGARPPAPRSPRLPASTSAARNA-SASPRSQSLS-------RRESPSPSHQA 681
Cdd:PHA03247  2840 PPPPGPPppslplGGSVAPGgdvrrRPPSRSPAAKPAAPARPPVRRLARPAvSRSTESFALPpdqperpPQPQAPPPPQP 2919

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1034651893  682 RPGVPPPRGVPPARAQPDGTPSPGGSKKGPRGKLQAQ 718
Cdd:PHA03247  2920 QPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 556-707 6.18e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 6.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034651893 556 LPRKSGRAAATRSRIPRP---IGLRMPMPVAAQQPASRSHGAAPALdtaitssrlqlQTPPGSATAADLRPKQPPGRGLG 632
Cdd:PRK07764  364 LPSASDDERGLLARLERLerrLGVAGGAGAPAAAAPSAAAAAPAAA-----------PAPAAAAPAAAAAPAPAAAPQPA 432

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034651893 633 PGRAQAGARPPAPRSPRLPASTSAARNASASPRSQSLSRRESPSPSHQARPGVPPPRGVPPARAQPDGTPSPGGS 707
Cdd:PRK07764  433 PAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGAD 507
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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