NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1034650653|ref|XP_016866473|]
View 

jouberin isoform X7 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
587-897 1.84e-37

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.82  E-value: 1.84e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  587 WKRLPGQACRIPNKHLFSLNAgergcfcLDFSHNGRILAAAcaSRDGYpIILYEIPSGRFMRELCGHLNIIYDLSWSKDD 666
Cdd:COG2319    105 WDLATGLLLRTLTGHTGAVRS-------VAFSPDGKTLASG--SADGT-VRLWDLATGKLLRTLTGHSGAVTSVAFSPDG 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  667 HYILTSSSDGTARIWknEINNTNTFRVLP-HPSFVYTAKFHPAvRELVVTGCYDSMIRIWKVemreDSAILVRQFDVHKS 745
Cdd:COG2319    175 KLLASGSDDGTVRLW--DLATGKLLRTLTgHTGAVRSVAFSPD-GKLLASGSADGTVRLWDL----ATGKLLRTLTGHSG 247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  746 FINSLCFDTEGHHMYSGDCTGVIVVWNtyVKINDLEHSVHHWTinkeiketefkgIPISYLEIHPNGKRLLIHTKDSTLR 825
Cdd:COG2319    248 SVRSVAFSPDGRLLASGSADGTVRLWD--LATGELLRTLTGHS------------GGVNSVAFSPDGKLLASGSDDGTVR 313

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034650653  826 IMDLRIlvARKFVGAANYREKIHS-TLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDlpFKSPIRDISYHP 897
Cdd:COG2319    314 LWDLAT--GKLLRTLTGHTGAVRSvAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG--HTGAVTSVAFSP 382
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
587-897 1.84e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.82  E-value: 1.84e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  587 WKRLPGQACRIPNKHLFSLNAgergcfcLDFSHNGRILAAAcaSRDGYpIILYEIPSGRFMRELCGHLNIIYDLSWSKDD 666
Cdd:COG2319    105 WDLATGLLLRTLTGHTGAVRS-------VAFSPDGKTLASG--SADGT-VRLWDLATGKLLRTLTGHSGAVTSVAFSPDG 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  667 HYILTSSSDGTARIWknEINNTNTFRVLP-HPSFVYTAKFHPAvRELVVTGCYDSMIRIWKVemreDSAILVRQFDVHKS 745
Cdd:COG2319    175 KLLASGSDDGTVRLW--DLATGKLLRTLTgHTGAVRSVAFSPD-GKLLASGSADGTVRLWDL----ATGKLLRTLTGHSG 247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  746 FINSLCFDTEGHHMYSGDCTGVIVVWNtyVKINDLEHSVHHWTinkeiketefkgIPISYLEIHPNGKRLLIHTKDSTLR 825
Cdd:COG2319    248 SVRSVAFSPDGRLLASGSADGTVRLWD--LATGELLRTLTGHS------------GGVNSVAFSPDGKLLASGSDDGTVR 313

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034650653  826 IMDLRIlvARKFVGAANYREKIHS-TLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDlpFKSPIRDISYHP 897
Cdd:COG2319    314 LWDLAT--GKLLRTLTGHTGAVRSvAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG--HTGAVTSVAFSP 382
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 611-907 1.02e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.91  E-value: 1.02e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  611 GCFCLDFSHNGRILAAACASRDgypIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWKneINNTNT 690
Cdd:cd00200     11 GVTCVAFSPDGKLLATGSGDGT---IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD--LETGEC 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  691 FRVL-PHPSFVYTAKFHPAvRELVVTGCYDSMIRIWKVEMREdsaiLVRQFDVHKSFINSLCFDTEGHHMYSGDctgviv 769
Cdd:cd00200     86 VRTLtGHTSYVSSVAFSPD-GRILSSSSRDKTIKVWDVETGK----CLTTLRGHTDWVNSVAFSPDGTFVASSS------ 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  770 vWNTYVKIndlehsvhhWTINKEIKETEFKG--IPISYLEIHPNGKRLLIHTKDSTLRIMDLRilvARKFVGAANYREK- 846
Cdd:cd00200    155 -QDGTIKL---------WDLRTGKCVATLTGhtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKCLGTLRGHENg 221

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034650653  847 IHSTLT-PCGTFLFAGSEDGIVYVWNPETGEQVAMYSDlpFKSPIRDISYHPFENMVAFCAF 907
Cdd:cd00200    222 VNSVAFsPDGYLLASGSEDGTIRVWDLRTGECVQTLSG--HTNSVTSLAWSPDGKRLASGSA 281
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 643-682 2.87e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 2.87e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1034650653   643 SGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWK 682
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
644-681 6.76e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 6.76e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1034650653  644 GRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIW 681
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
587-897 1.84e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.82  E-value: 1.84e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  587 WKRLPGQACRIPNKHLFSLNAgergcfcLDFSHNGRILAAAcaSRDGYpIILYEIPSGRFMRELCGHLNIIYDLSWSKDD 666
Cdd:COG2319    105 WDLATGLLLRTLTGHTGAVRS-------VAFSPDGKTLASG--SADGT-VRLWDLATGKLLRTLTGHSGAVTSVAFSPDG 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  667 HYILTSSSDGTARIWknEINNTNTFRVLP-HPSFVYTAKFHPAvRELVVTGCYDSMIRIWKVemreDSAILVRQFDVHKS 745
Cdd:COG2319    175 KLLASGSDDGTVRLW--DLATGKLLRTLTgHTGAVRSVAFSPD-GKLLASGSADGTVRLWDL----ATGKLLRTLTGHSG 247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  746 FINSLCFDTEGHHMYSGDCTGVIVVWNtyVKINDLEHSVHHWTinkeiketefkgIPISYLEIHPNGKRLLIHTKDSTLR 825
Cdd:COG2319    248 SVRSVAFSPDGRLLASGSADGTVRLWD--LATGELLRTLTGHS------------GGVNSVAFSPDGKLLASGSDDGTVR 313

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034650653  826 IMDLRIlvARKFVGAANYREKIHS-TLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDlpFKSPIRDISYHP 897
Cdd:COG2319    314 LWDLAT--GKLLRTLTGHTGAVRSvAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG--HTGAVTSVAFSP 382
WD40 COG2319
WD40 repeat [General function prediction only];
600-874 1.31e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.57  E-value: 1.31e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  600 KHLFSLNAGERGCFCLDFSHNGRILAAAcaSRDGyPIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTAR 679
Cdd:COG2319    153 KLLRTLTGHSGAVTSVAFSPDGKLLASG--SDDG-TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  680 IWknEINNTNTFRVLP-HPSFVYTAKFHPAvRELVVTGCYDSMIRIWKVemreDSAILVRQFDVHKSFINSLCFDTEGHH 758
Cdd:COG2319    230 LW--DLATGKLLRTLTgHSGSVRSVAFSPD-GRLLASGSADGTVRLWDL----ATGELLRTLTGHSGGVNSVAFSPDGKL 302

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  759 MYSGDCTGVIVVWNtyvkindlehsvhhWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLR-ILVARKF 837
Cdd:COG2319    303 LASGSDDGTVRLWD--------------LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAtGELLRTL 368

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1034650653  838 VGAANYrekIHS-TLTPCGTFLFAGSEDGIVYVWNPET 874
Cdd:COG2319    369 TGHTGA---VTSvAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 611-907 1.02e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.91  E-value: 1.02e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  611 GCFCLDFSHNGRILAAACASRDgypIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWKneINNTNT 690
Cdd:cd00200     11 GVTCVAFSPDGKLLATGSGDGT---IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD--LETGEC 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  691 FRVL-PHPSFVYTAKFHPAvRELVVTGCYDSMIRIWKVEMREdsaiLVRQFDVHKSFINSLCFDTEGHHMYSGDctgviv 769
Cdd:cd00200     86 VRTLtGHTSYVSSVAFSPD-GRILSSSSRDKTIKVWDVETGK----CLTTLRGHTDWVNSVAFSPDGTFVASSS------ 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  770 vWNTYVKIndlehsvhhWTINKEIKETEFKG--IPISYLEIHPNGKRLLIHTKDSTLRIMDLRilvARKFVGAANYREK- 846
Cdd:cd00200    155 -QDGTIKL---------WDLRTGKCVATLTGhtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKCLGTLRGHENg 221

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034650653  847 IHSTLT-PCGTFLFAGSEDGIVYVWNPETGEQVAMYSDlpFKSPIRDISYHPFENMVAFCAF 907
Cdd:cd00200    222 VNSVAFsPDGYLLASGSEDGTIRVWDLRTGECVQTLSG--HTNSVTSLAWSPDGKRLASGSA 281
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 580-871 3.08e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.37  E-value: 3.08e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  580 ESKEVIKWKRLPGQACRIPNKHLFSLNAgergcfCLDFSHNGRIlaaACASRDGYpIILYEIPSGRFMRELCGHLNIIYD 659
Cdd:cd00200     29 GDGTIKVWDLETGELLRTLKGHTGPVRD------VAASADGTYL---ASGSSDKT-IRLWDLETGECVRTLTGHTSYVSS 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  660 LSWSKDDHYILTSSSDGTARIWkNEINNTNTFRVLPHPSFVYTAKFHPaVRELVVTGCYDSMIRIWKVEmredSAILVRQ 739
Cdd:cd00200     99 VAFSPDGRILSSSSRDKTIKVW-DVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLR----TGKCVAT 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  740 FDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKindlehsvhhwtinKEIKETEFKGIPISYLEIHPNGKRLLIHT 819
Cdd:cd00200    173 LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG--------------KCLGTLRGHENGVNSVAFSPDGYLLASGS 238

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1034650653  820 KDSTLRIMDLRILV-ARKFVGaanYREKIHS-TLTPCGTFLFAGSEDGIVYVWN 871
Cdd:cd00200    239 EDGTIRVWDLRTGEcVQTLSG---HTNSVTSlAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 648-919 1.51e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.11  E-value: 1.51e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  648 RELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWkneinNTNTFRVL----PHPSFVYTAKFHpAVRELVVTGCYDSMIR 723
Cdd:cd00200      3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW-----DLETGELLrtlkGHTGPVRDVAAS-ADGTYLASGSSDKTIR 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  724 IWKVEMREdsaiLVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTyvkindlehsvhhwTINKEIKETEFKGIPI 803
Cdd:cd00200     77 LWDLETGE----CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV--------------ETGKCLTTLRGHTDWV 138

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  804 SYLEIHPNGKRLLIHTKDSTLRIMDLRIL-VARKFVGaanYREKIHS-TLTPCGTFLFAGSEDGIVYVWNPETGEQVAMY 881
Cdd:cd00200    139 NSVAFSPDGTFVASSSQDGTIKLWDLRTGkCVATLTG---HTGEVNSvAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL 215

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1034650653  882 SdlPFKSPIRDISYHPFENMVAFCAFGQNepilLYIYD 919
Cdd:cd00200    216 R--GHENGVNSVAFSPDGYLLASGSEDGT----IRVWD 247
WD40 COG2319
WD40 repeat [General function prediction only];
615-897 1.58e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 1.58e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  615 LDFSHNGRILAAACASRDgypIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWknEINNTNTFRVL 694
Cdd:COG2319     42 LAASPDGARLAAGAGDLT---LLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW--DLATGLLLRTL 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  695 -PHPSFVYTAKFHPAVReLVVTGCYDSMIRIWKVEMREdsaiLVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNt 773
Cdd:COG2319    117 tGHTGAVRSVAFSPDGK-TLASGSADGTVRLWDLATGK----LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD- 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  774 yvkindlehsvhhWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLR-ILVARKFVGAANYrekIHS-TL 851
Cdd:COG2319    191 -------------LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGS---VRSvAF 254

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 1034650653  852 TPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDlpFKSPIRDISYHP 897
Cdd:COG2319    255 SPDGRLLASGSADGTVRLWDLATGELLRTLTG--HSGGVNSVAFSP 298
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 736-905 1.42e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.51  E-value: 1.42e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  736 LVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTyvkindlehsvhhwtiNKEIKETEFKG--IPISYLEIHPNGK 813
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL----------------ETGELLRTLKGhtGPVRDVAASADGT 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  814 RLLIHTKDSTLRIMDLRIL-VARKFVGAANYrekIHS-TLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDlpFKSPIR 891
Cdd:cd00200     65 YLASGSSDKTIRLWDLETGeCVRTLTGHTSY---VSSvAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG--HTDWVN 139

                          170
                   ....*....|....
gi 1034650653  892 DISYHPFENMVAFC 905
Cdd:cd00200    140 SVAFSPDGTFVASS 153
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 643-682 2.87e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 2.87e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1034650653   643 SGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWK 682
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
644-681 6.76e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 6.76e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1034650653  644 GRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIW 681
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 626-727 3.01e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 42.35  E-value: 3.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034650653  626 AACASRDGYP-IILYEIPSGRfMRELCGHLNIIYDLSWSKDDHYIL-TSSSDGTARIWKNEINNTNTFRVLPHPSFVYTA 703
Cdd:COG0823      2 AFTLSRDGNSdIYVVDLDGGE-PRRLTNSPGIDTSPAWSPDGRRIAfTSDRGGGPQIYVVDADGGEPRRLTFGGGYNASP 80

                           90       100
                   ....*....|....*....|....
gi 1034650653  704 KFHPAVRELVVTGCYDSMIRIWKV 727
Cdd:COG0823     81 SWSPDGKRLAFVSRSDGRFDIYVL 104
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 736-772 4.61e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 4.61e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1034650653   736 LVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWN 772
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
736-772 6.75e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 6.75e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1034650653  736 LVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWN 772
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH