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Conserved domains on  [gi|1034648513|ref|XP_016865771|]
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parkin coregulated gene protein isoform X7 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ParcG super family cl20396
Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA ...
 1-86 5.04e-47

Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA to the Parkin gene product and the two appear to be transcribed under the same promoter. The protein has predicted alpha-helical and beta-sheet domains which suggest its function is in the ubiquitin/proteasome system. Mutations in parkin are the genetic cause of early-onset and autosomal recessive juvenile parkinsonism.


The actual alignment was detected with superfamily member pfam10274:

Pssm-ID: 431190  Cd Length: 183  Bit Score: 153.22  E-value: 5.04e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648513   1 MTFPYEFFARQGIHDMLEH-GGNKILPVLPQLIIPIKNALNLRNRQVICVTLKVLQHLVVSAEMVGKALVPYYRQILPVL 79
Cdd:pfam10274  50 TKHPYRFVARNGIRDLLEAeGGEKILPVLPQLILPLKAALNTRDPEVFCVALKVLQLLVKSSDLIGEALVPYYRQLLPVL 129


                  ....*..
gi 1034648513  80 NIFKNMN 86
Cdd:pfam10274 130 NLFKNKR 136
 
Name Accession Description Interval E-value
ParcG pfam10274
Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA ...
 1-86 5.04e-47

Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA to the Parkin gene product and the two appear to be transcribed under the same promoter. The protein has predicted alpha-helical and beta-sheet domains which suggest its function is in the ubiquitin/proteasome system. Mutations in parkin are the genetic cause of early-onset and autosomal recessive juvenile parkinsonism.


Pssm-ID: 431190  Cd Length: 183  Bit Score: 153.22  E-value: 5.04e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648513   1 MTFPYEFFARQGIHDMLEH-GGNKILPVLPQLIIPIKNALNLRNRQVICVTLKVLQHLVVSAEMVGKALVPYYRQILPVL 79
Cdd:pfam10274  50 TKHPYRFVARNGIRDLLEAeGGEKILPVLPQLILPLKAALNTRDPEVFCVALKVLQLLVKSSDLIGEALVPYYRQLLPVL 129


                  ....*..
gi 1034648513  80 NIFKNMN 86
Cdd:pfam10274 130 NLFKNKR 136
 
Name Accession Description Interval E-value
ParcG pfam10274
Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA ...
 1-86 5.04e-47

Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA to the Parkin gene product and the two appear to be transcribed under the same promoter. The protein has predicted alpha-helical and beta-sheet domains which suggest its function is in the ubiquitin/proteasome system. Mutations in parkin are the genetic cause of early-onset and autosomal recessive juvenile parkinsonism.


Pssm-ID: 431190  Cd Length: 183  Bit Score: 153.22  E-value: 5.04e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648513   1 MTFPYEFFARQGIHDMLEH-GGNKILPVLPQLIIPIKNALNLRNRQVICVTLKVLQHLVVSAEMVGKALVPYYRQILPVL 79
Cdd:pfam10274  50 TKHPYRFVARNGIRDLLEAeGGEKILPVLPQLILPLKAALNTRDPEVFCVALKVLQLLVKSSDLIGEALVPYYRQLLPVL 129


                  ....*..
gi 1034648513  80 NIFKNMN 86
Cdd:pfam10274 130 NLFKNKR 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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