NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1034648411|ref|XP_016865734|]
View 

transcription initiation factor TFIID subunit 8 isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HFD_TAF8 cd22918
histone-fold domain found in transcription initiation factor TFIID subunit 8 (TAF8) and ...
 32-115 3.64e-49

histone-fold domain found in transcription initiation factor TFIID subunit 8 (TAF8) and similar proteins; TAF8, also called TATA Binding Protein (TBP) associated factor 8, protein taube nuss, TBP-associated factor 43 kDa, TBP-associated factor 8, or transcription initiation factor TFIID 43 kDa subunit (TAFII-43, TAFII43), is a component of the TFIID complex that is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TFIID is one of the general transcription factors required for accurate and regulated initiation by RNA polymerase II. It plays a central role in mediating promoter responses to various activators and repressors. TAF8 mediates both basal and activator-dependent transcription. It is involved in the differentiation of preadipocyte fibroblasts to adipocytes, however, it does not seem to play a role in differentiation of myoblasts. TAF8 is required for the integration of TAF10 in the TAF complex. It may be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo.


:

Pssm-ID: 467043  Cd Length: 84  Bit Score: 155.01  E-value: 3.64e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648411  32 ARRRTLQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNVDTLPAYA 111
Cdd:cd22918     1 ARRRVLQVAVAALCLEAGFESAEKSALETLTEMLQSYLTEIGRSSKAYCELAGRTEPTLSDVVLALIDMGINVDSLPEYA 80


                  ....
gi 1034648411 112 KRSQ 115
Cdd:cd22918    81 KRPQ 84
TAF8_C pfam10406
Transcription factor TFIID complex subunit 8 C-term; This is the C-terminal, Delta, part of ...
 145-191 1.86e-08

Transcription factor TFIID complex subunit 8 C-term; This is the C-terminal, Delta, part of the TAF8 protein. The N-terminal is generally the histone fold domain, Bromo_TP (pfam07524). TAF8 is one of the key subunits of the transcription factor for pol II, TFIID. TAF8 is one of the several general cofactors which are typically involved in gene activation to bring about the communication between gene-specific transcription factors and components of the general transcription machinery.


:

Pssm-ID: 431262  Cd Length: 49  Bit Score: 49.06  E-value: 1.86e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1034648411 145 HIPSHFPEFPDPHTYIKTPEDSGAEKENTSVLQQnpSLSGSRNGEEN 191
Cdd:pfam10406   1 YIPSWLPPFPPPHTYKRTPVYPERITDPKKIREK--AAEQSRLAEKA 45
 
Name Accession Description Interval E-value
HFD_TAF8 cd22918
histone-fold domain found in transcription initiation factor TFIID subunit 8 (TAF8) and ...
 32-115 3.64e-49

histone-fold domain found in transcription initiation factor TFIID subunit 8 (TAF8) and similar proteins; TAF8, also called TATA Binding Protein (TBP) associated factor 8, protein taube nuss, TBP-associated factor 43 kDa, TBP-associated factor 8, or transcription initiation factor TFIID 43 kDa subunit (TAFII-43, TAFII43), is a component of the TFIID complex that is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TFIID is one of the general transcription factors required for accurate and regulated initiation by RNA polymerase II. It plays a central role in mediating promoter responses to various activators and repressors. TAF8 mediates both basal and activator-dependent transcription. It is involved in the differentiation of preadipocyte fibroblasts to adipocytes, however, it does not seem to play a role in differentiation of myoblasts. TAF8 is required for the integration of TAF10 in the TAF complex. It may be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo.


Pssm-ID: 467043  Cd Length: 84  Bit Score: 155.01  E-value: 3.64e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648411  32 ARRRTLQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNVDTLPAYA 111
Cdd:cd22918     1 ARRRVLQVAVAALCLEAGFESAEKSALETLTEMLQSYLTEIGRSSKAYCELAGRTEPTLSDVVLALIDMGINVDSLPEYA 80


                  ....
gi 1034648411 112 KRSQ 115
Cdd:cd22918    81 KRPQ 84
Bromo_TP pfam07524
Bromodomain associated; This domain is predicted to bind DNA and is often found associated ...
 29-106 6.83e-32

Bromodomain associated; This domain is predicted to bind DNA and is often found associated with pfam00439 and in transcription factors. It has a histone-like fold.


Pssm-ID: 400073  Cd Length: 77  Bit Score: 110.88  E-value: 6.83e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034648411  29 YHLARRrTLQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNVDT 106
Cdd:pfam07524   1 DELAHD-LLKVAVSQILEHAGFDSAEESALETLTDIAQSYIRELGEQAKSFAEHAGRSEPTLFDVVLTLVEMGINVGE 77
BTP smart00576
Bromodomain transcription factors and PHD domain containing proteins; subdomain of archael ...
 29-106 1.44e-28

Bromodomain transcription factors and PHD domain containing proteins; subdomain of archael histone-like transcription factors


Pssm-ID: 128846  Cd Length: 77  Bit Score: 102.40  E-value: 1.44e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034648411   29 YHLARRRtLQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNVDT 106
Cdd:smart00576   1 NELAFAL-LRIAVAQILESAGFDSFQESALETLTDILQSYIQELGRTAHSYAELAGRTEPNLGDVVLALENLGISVGE 77
TAF8_C pfam10406
Transcription factor TFIID complex subunit 8 C-term; This is the C-terminal, Delta, part of ...
 145-191 1.86e-08

Transcription factor TFIID complex subunit 8 C-term; This is the C-terminal, Delta, part of the TAF8 protein. The N-terminal is generally the histone fold domain, Bromo_TP (pfam07524). TAF8 is one of the key subunits of the transcription factor for pol II, TFIID. TAF8 is one of the several general cofactors which are typically involved in gene activation to bring about the communication between gene-specific transcription factors and components of the general transcription machinery.


Pssm-ID: 431262  Cd Length: 49  Bit Score: 49.06  E-value: 1.86e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1034648411 145 HIPSHFPEFPDPHTYIKTPEDSGAEKENTSVLQQnpSLSGSRNGEEN 191
Cdd:pfam10406   1 YIPSWLPPFPPPHTYKRTPVYPERITDPKKIREK--AAEQSRLAEKA 45
TAF8 cd08049
TATA Binding Protein (TBP) Associated Factor 8; The TATA Binding Protein (TBP) Associated ...
 144-164 1.08e-07

TATA Binding Protein (TBP) Associated Factor 8; The TATA Binding Protein (TBP) Associated Factor 8 (TAF8) is one of several TAFs that bind TBP, and is involved in forming the Transcription Factor IID (TFIID) complex. TFIID is one of seven General Transcription Factors (GTF) (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIID) that are involved in accurate initiation of transcription by RNA polymerase II in eukaryotes. TFIID plays an important role in the recognition of promoter DNA and the assembly of the preinitiation complex. The TFIID complex is composed of the TBP and at least 13 TAFs. TAFs from various species were originally named by their predicted molecular weight or their electrophoretic mobility in polyacrylamide gels. A new, unified nomenclature for the pol II TAFs has been suggested to show the relationship between TAF orthologs and paralogs. Several hypotheses are proposed for TAFs' functions, such as serving as activator-binding sites, involvement in the core-promoter recognition, or a role in the essential catalytic activity of the complex. The mouse ortholog of TAF8 is called taube nuss protein (TBN), and is required for early embryonic development. TBN mutant mice exhibit disturbances in the balance between cell death and cell survival in the early embryo. TAF8 plays a role in the differentiation of preadipocyte fibroblasts to adipocytes; it is also required for the integration of TAF10 into the TAF complex. In yeast and human cells, TAFs have been found as components of other complexes besides TFIID. TAF8 is also a component of a small TAF complex (SMAT), which contains TAF8, TAF10 and SUPT7L. Several TAFs interact via histone-fold motifs. The histone fold (HFD) is the interaction motif involved in heterodimerization of the core histones and their assembly into nucleosome octamer. TAF8 contains an H4 related histone fold motif, and interacts with several subunits of TFIID, including TBP and the histone-fold protein TAF10. Currently, five HF-containing TAF pairs have been described or suggested to exist in TFIID: TAF6-TAF9, TAF4-TAF12, TAF11-TAF13, TAF8-TAF10 and TAF3-TAF10.


Pssm-ID: 176263  Cd Length: 54  Bit Score: 46.88  E-value: 1.08e-07
                          10        20
                  ....*....|....*....|.
gi 1034648411 144 PHIPSHFPEFPDPHTYIKTPE 164
Cdd:cd08049     1 AHIPSWLPPFPDPHTYKRTPT 21
 
Name Accession Description Interval E-value
HFD_TAF8 cd22918
histone-fold domain found in transcription initiation factor TFIID subunit 8 (TAF8) and ...
 32-115 3.64e-49

histone-fold domain found in transcription initiation factor TFIID subunit 8 (TAF8) and similar proteins; TAF8, also called TATA Binding Protein (TBP) associated factor 8, protein taube nuss, TBP-associated factor 43 kDa, TBP-associated factor 8, or transcription initiation factor TFIID 43 kDa subunit (TAFII-43, TAFII43), is a component of the TFIID complex that is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TFIID is one of the general transcription factors required for accurate and regulated initiation by RNA polymerase II. It plays a central role in mediating promoter responses to various activators and repressors. TAF8 mediates both basal and activator-dependent transcription. It is involved in the differentiation of preadipocyte fibroblasts to adipocytes, however, it does not seem to play a role in differentiation of myoblasts. TAF8 is required for the integration of TAF10 in the TAF complex. It may be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo.


Pssm-ID: 467043  Cd Length: 84  Bit Score: 155.01  E-value: 3.64e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648411  32 ARRRTLQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNVDTLPAYA 111
Cdd:cd22918     1 ARRRVLQVAVAALCLEAGFESAEKSALETLTEMLQSYLTEIGRSSKAYCELAGRTEPTLSDVVLALIDMGINVDSLPEYA 80


                  ....
gi 1034648411 112 KRSQ 115
Cdd:cd22918    81 KRPQ 84
Bromo_TP pfam07524
Bromodomain associated; This domain is predicted to bind DNA and is often found associated ...
 29-106 6.83e-32

Bromodomain associated; This domain is predicted to bind DNA and is often found associated with pfam00439 and in transcription factors. It has a histone-like fold.


Pssm-ID: 400073  Cd Length: 77  Bit Score: 110.88  E-value: 6.83e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034648411  29 YHLARRrTLQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNVDT 106
Cdd:pfam07524   1 DELAHD-LLKVAVSQILEHAGFDSAEESALETLTDIAQSYIRELGEQAKSFAEHAGRSEPTLFDVVLTLVEMGINVGE 77
BTP smart00576
Bromodomain transcription factors and PHD domain containing proteins; subdomain of archael ...
 29-106 1.44e-28

Bromodomain transcription factors and PHD domain containing proteins; subdomain of archael histone-like transcription factors


Pssm-ID: 128846  Cd Length: 77  Bit Score: 102.40  E-value: 1.44e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034648411   29 YHLARRRtLQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNVDT 106
Cdd:smart00576   1 NELAFAL-LRIAVAQILESAGFDSFQESALETLTDILQSYIQELGRTAHSYAELAGRTEPNLGDVVLALENLGISVGE 77
HFD_SF cd00076
histone fold domain (HFD) superfamily; The histone fold domain (HFD) is a structurally ...
 37-97 2.23e-14

histone fold domain (HFD) superfamily; The histone fold domain (HFD) is a structurally conserved interaction motif involved in heterodimerization of the core histones and their assembly into the nucleosome octamer. Histone fold heterodimers play crucial roles in gene regulation. The minimal HFD consists of three alpha helices connected by two short, unstructured loops. The HFD is found in core histones, TATA box-binding protein-associated factors (TAFs), and many other transcription factors. HFD plays a role in the nucleosomal core particle by conserving histone interactions; these contain more than one HFD. The structure of the nucleosome core particle has two modes that have the largest interaction surfaces, and these are the H3-H4 and H2A-H2B heterodimer interactions. Several TAFs interact via histone-fold (HF) motifs. Five HF-containing TAF pairs have been described in transcription factor II D (TFIID): TAF6-TAF9, TAF4-TAF12, TAF11-TAF13, TAF8-TAF10 and TAF3-TAF10.


Pssm-ID: 467021  Cd Length: 63  Bit Score: 64.93  E-value: 2.23e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034648411  37 LQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTL 97
Cdd:cd00076     2 LRSAVARILKSAGFDSVSKSALELLSDLLERYLEELARAAKAYAELAGRTTPNAEDVELAL 62
HFD_TAF3 cd22916
histone-fold domain found in transcription initiation factor TFIID subunit 3 (TAF3) and ...
 34-110 3.63e-13

histone-fold domain found in transcription initiation factor TFIID subunit 3 (TAF3) and similar proteins; TAF3, also called TATA Binding Protein (TBP) associated factor 3, 140 kDa TATA box-binding protein-associated factor, TBP-associated factor 3, or transcription initiation factor TFIID 140 kDa subunit (TAF(II)140, TAF140, TAFII-140,TAFII140), is a component of the TFIID complex that is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TFIID is one of the general transcription factors required for accurate and regulated initiation by RNA polymerase II. It plays a central role in mediating promoter responses to various activators and repressors.


Pssm-ID: 467041  Cd Length: 92  Bit Score: 62.62  E-value: 3.63e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034648411  34 RRTLQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNVDTLPAY 110
Cdd:cd22916     5 RSLLRVVVAQICQNVGWHSIQSSPLDLLTDVLQRYLLELARSAHRYAEQYGRTEPNLDDLGLAFKDMGISLNELEDY 81
HFD_SPT7 cd22927
histone-fold domain found in protein SPT7 and similar proteins; SPT7, also called suppressor ...
 34-112 3.09e-11

histone-fold domain found in protein SPT7 and similar proteins; SPT7, also called suppressor of Ty 7 homolog, is a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. SAGA (Spt-Ada-Gcn5-acetyltransferase) is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TATA binding protein (TBP) interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA (SAGA altered, SPT8 absent), an altered form of SAGA, may be involved in positive transcriptional regulation. Besides lacking SPT8, SALSA contains an SPT7 subunit that is truncated. SLIK (SAGA-like) is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus. SPT7 is transcriptional activator of TY elements and other genes.


Pssm-ID: 467052  Cd Length: 117  Bit Score: 58.32  E-value: 3.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648411  34 RRTLQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQpTLSDIVV-TLVEMGF-NVDTLPAYA 111
Cdd:cd22927    13 RAALRRSVAKLLAHAGFEGAQPSALDVLTDIAADYLSNLGRTLRLYLDRYSKKM-SPEEILLhTLFENGVeDISDLESYI 91


                  .
gi 1034648411 112 K 112
Cdd:cd22927    92 K 92
TAF8_C pfam10406
Transcription factor TFIID complex subunit 8 C-term; This is the C-terminal, Delta, part of ...
 145-191 1.86e-08

Transcription factor TFIID complex subunit 8 C-term; This is the C-terminal, Delta, part of the TAF8 protein. The N-terminal is generally the histone fold domain, Bromo_TP (pfam07524). TAF8 is one of the key subunits of the transcription factor for pol II, TFIID. TAF8 is one of the several general cofactors which are typically involved in gene activation to bring about the communication between gene-specific transcription factors and components of the general transcription machinery.


Pssm-ID: 431262  Cd Length: 49  Bit Score: 49.06  E-value: 1.86e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1034648411 145 HIPSHFPEFPDPHTYIKTPEDSGAEKENTSVLQQnpSLSGSRNGEEN 191
Cdd:pfam10406   1 YIPSWLPPFPPPHTYKRTPVYPERITDPKKIREK--AAEQSRLAEKA 45
HFD_SUPT7L cd06847
histone-fold domain found in Suppressor of Ty 7-like (SUPT7L) and similar proteins; SUPT7L, ...
 34-103 5.75e-08

histone-fold domain found in Suppressor of Ty 7-like (SUPT7L) and similar proteins; SUPT7L, also called STAGA complex 65 subunit gamma, adenocarcinoma antigen ART1, SPTF-associated factor 65 gamma, or STAF65gamma, is the ortholog of yeast SPT7 in mammalian cells. It is highly similar to yeast SPT7 but lacks the N-terminal SPT7 bromodomain. SUPT7L is a protein component specific to STAGA (SPT3-TAF9-GCN5 Acetyltransferase)-type complexes. It plays an essential role for the integrity of the STAGA complex.


Pssm-ID: 467022  Cd Length: 86  Bit Score: 48.72  E-value: 5.75e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034648411  34 RRTLQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLS-DIVV-TLVEMGFN 103
Cdd:cd06847     6 RQLLRKSVAAILAHAGFDSASESALEVLTDVLDEFLRKFTRLLRSAVDREALSGETGFpDILErVLHEMGIG 77
TAF8 cd08049
TATA Binding Protein (TBP) Associated Factor 8; The TATA Binding Protein (TBP) Associated ...
 144-164 1.08e-07

TATA Binding Protein (TBP) Associated Factor 8; The TATA Binding Protein (TBP) Associated Factor 8 (TAF8) is one of several TAFs that bind TBP, and is involved in forming the Transcription Factor IID (TFIID) complex. TFIID is one of seven General Transcription Factors (GTF) (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIID) that are involved in accurate initiation of transcription by RNA polymerase II in eukaryotes. TFIID plays an important role in the recognition of promoter DNA and the assembly of the preinitiation complex. The TFIID complex is composed of the TBP and at least 13 TAFs. TAFs from various species were originally named by their predicted molecular weight or their electrophoretic mobility in polyacrylamide gels. A new, unified nomenclature for the pol II TAFs has been suggested to show the relationship between TAF orthologs and paralogs. Several hypotheses are proposed for TAFs' functions, such as serving as activator-binding sites, involvement in the core-promoter recognition, or a role in the essential catalytic activity of the complex. The mouse ortholog of TAF8 is called taube nuss protein (TBN), and is required for early embryonic development. TBN mutant mice exhibit disturbances in the balance between cell death and cell survival in the early embryo. TAF8 plays a role in the differentiation of preadipocyte fibroblasts to adipocytes; it is also required for the integration of TAF10 into the TAF complex. In yeast and human cells, TAFs have been found as components of other complexes besides TFIID. TAF8 is also a component of a small TAF complex (SMAT), which contains TAF8, TAF10 and SUPT7L. Several TAFs interact via histone-fold motifs. The histone fold (HFD) is the interaction motif involved in heterodimerization of the core histones and their assembly into nucleosome octamer. TAF8 contains an H4 related histone fold motif, and interacts with several subunits of TFIID, including TBP and the histone-fold protein TAF10. Currently, five HF-containing TAF pairs have been described or suggested to exist in TFIID: TAF6-TAF9, TAF4-TAF12, TAF11-TAF13, TAF8-TAF10 and TAF3-TAF10.


Pssm-ID: 176263  Cd Length: 54  Bit Score: 46.88  E-value: 1.08e-07
                          10        20
                  ....*....|....*....|.
gi 1034648411 144 PHIPSHFPEFPDPHTYIKTPE 164
Cdd:cd08049     1 AHIPSWLPPFPDPHTYKRTPT 21
HFD_TAF9 cd07979
histone-fold domain found in transcription initiation factor TFIID subunit 9 (TAF9) and ...
 40-93 2.24e-04

histone-fold domain found in transcription initiation factor TFIID subunit 9 (TAF9) and similar proteins; The family includes TAF9 (also called TATA Binding Protein (TBP) associated factor 9, RNA polymerase II TBP-associated factor subunit G, STAF31/32, transcription initiation factor TFIID 31 kDa subunit, TAFII-31, TAFII31, transcription initiation factor TFIID 32 kDa subunit, TAFII-32, or TAFII32) and TAF9-like (also called transcription initiation factor TFIID subunit 9B, neuronal cell death-related protein 7, DN-7, or transcription-associated factor TAFII31L), which are essential for cell viability. They are involved in transcriptional activation as well as the repression of distinct but overlapping sets of genes. They may have roles in gene regulation associated with apoptosis. Both TAF9 and TAF9-like are TAFs that are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. TAF9 interacts directly with different transcription factors such as p53, herpes simplex virus activator vp16, and the basal transcription factor TFIIB.


Pssm-ID: 467024  Cd Length: 95  Bit Score: 39.13  E-value: 2.24e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034648411  40 VVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDI 93
Cdd:cd07979     6 VIRAILKSMGVTDYEPRVVNQLLEFAYRYTTEVLQDAKVYAEHAGRSQIDEEDV 59
Bromo_TP_like pfam17027
Histone-fold protein; This is a family of microsporidia-specific sequences that have distant ...
 37-73 7.87e-03

Histone-fold protein; This is a family of microsporidia-specific sequences that have distant homology to the Bromo_TP family, pfam07524.


Pssm-ID: 374950  Cd Length: 119  Bit Score: 35.08  E-value: 7.87e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1034648411  37 LQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIG 73
Cdd:pfam17027   3 LKLSIVEILLQSGFERTSEQSLNILTDLLKYYIEKIL 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH