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Conserved domains on  [gi|1034646861|ref|XP_016865573|]
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synphilin-1 isoform X13 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
369-521 5.14e-14

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.68  E-value: 5.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646861 369 ILNIVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLmGEDcLNERNTEKLTPAGLAIKNGQLECV 448
Cdd:COG0666    59 LAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEA-GAD-VNARDKDGETPLHLAAYNGNLEIV 136

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034646861 449 RWMVsetEAIAEL-SCSKDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGCIQ 521
Cdd:COG0666   137 KLLL---EAGADVnAQDNDGNTPLHLAAANGNLEIVKLLL----EAGADVNARDNDGETPLHLAAENGHLEIVK 203
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
369-521 5.14e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.68  E-value: 5.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646861 369 ILNIVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLmGEDcLNERNTEKLTPAGLAIKNGQLECV 448
Cdd:COG0666    59 LAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEA-GAD-VNARDKDGETPLHLAAYNGNLEIV 136

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034646861 449 RWMVsetEAIAEL-SCSKDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGCIQ 521
Cdd:COG0666   137 KLLL---EAGADVnAQDNDGNTPLHLAAANGNLEIVKLLL----EAGADVNARDNDGETPLHLAAENGHLEIVK 203
Ank_2 pfam12796
Ankyrin repeats (3 copies);
401-501 1.89e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.51  E-value: 1.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646861 401 LHIAASQGHAECLQHLTSLMGEdcLNERNTEKLTPAGLAIKNGQLECVRWMVSetEAIAELSCSKDFPslIHYAGCYGQE 480
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAD--ANLQDKNGRTALHLAAKNGHLEIVKLLLE--HADVNLKDNGRTA--LHYAARSGHL 74

                          90       100
                  ....*....|....*....|.
gi 1034646861 481 KILLWLLqfmqEQGISLDEVD 501
Cdd:pfam12796  75 EIVKLLL----EKGADINVKD 91
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
369-521 5.14e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.68  E-value: 5.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646861 369 ILNIVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLmGEDcLNERNTEKLTPAGLAIKNGQLECV 448
Cdd:COG0666    59 LAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEA-GAD-VNARDKDGETPLHLAAYNGNLEIV 136

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034646861 449 RWMVsetEAIAEL-SCSKDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGCIQ 521
Cdd:COG0666   137 KLLL---EAGADVnAQDNDGNTPLHLAAANGNLEIVKLLL----EAGADVNARDNDGETPLHLAAENGHLEIVK 203
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
369-521 8.32e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 66.13  E-value: 8.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646861 369 ILNIVKEGQISLLPHLAADNLD-KIHDENGNNLLHIAASQGHAECLQHLTSLmGEDcLNERNTEKLTPAGLAIKNGQLEC 447
Cdd:COG0666    91 LHAAARNGDLEIVKLLLEAGADvNARDKDGETPLHLAAYNGNLEIVKLLLEA-GAD-VNAQDNDGNTPLHLAAANGNLEI 168

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034646861 448 VRWMVsetEAIAEL-SCSKDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGCIQ 521
Cdd:COG0666   169 VKLLL---EAGADVnARDNDGETPLHLAAENGHLEIVKLLL----EAGADVNAKDNDGKTALDLAAENGNLEIVK 236
Ank_2 pfam12796
Ankyrin repeats (3 copies);
401-501 1.89e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.51  E-value: 1.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646861 401 LHIAASQGHAECLQHLTSLMGEdcLNERNTEKLTPAGLAIKNGQLECVRWMVSetEAIAELSCSKDFPslIHYAGCYGQE 480
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAD--ANLQDKNGRTALHLAAKNGHLEIVKLLLE--HADVNLKDNGRTA--LHYAARSGHL 74

                          90       100
                  ....*....|....*....|.
gi 1034646861 481 KILLWLLqfmqEQGISLDEVD 501
Cdd:pfam12796  75 EIVKLLL----EKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
369-521 1.52e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.20  E-value: 1.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646861 369 ILNIVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLtsLMGEDCLNERNTEKLTPAGLAIKNGQLECV 448
Cdd:COG0666    26 LAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLL--LAAGADINAKDDGGNTLLHAAARNGDLEIV 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034646861 449 RWMVsetEAIAEL-SCSKDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGCIQ 521
Cdd:COG0666   104 KLLL---EAGADVnARDKDGETPLHLAAYNGNLEIVKLLL----EAGADVNAQDNDGNTPLHLAAANGNLEIVK 170
Ank_2 pfam12796
Ankyrin repeats (3 copies);
373-453 2.58e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 51.66  E-value: 2.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646861 373 VKEGQISLLPHLAADNLDK-IHDENGNNLLHIAASQGHAECLQHLTSLMGEDClnerNTEKLTPAGLAIKNGQLECVRWM 451
Cdd:pfam12796   5 AKNGNLELVKLLLENGADAnLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL----KDNGRTALHYAARSGHLEIVKLL 80


                  ..
gi 1034646861 452 VS 453
Cdd:pfam12796  81 LE 82
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
336-517 1.49e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 53.03  E-value: 1.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646861 336 AAESKPEEQVSGLNRTSSQGPEERSEYLKKVKSILNIVKEGQISLLpHLAADN---------LDK-----IHDENGNNLL 401
Cdd:COG0666    79 DINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPL-HLAAYNgnleivkllLEAgadvnAQDNDGNTPL 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646861 402 HIAASQGHAECLQHLTSLmGEDcLNERNTEKLTPAGLAIKNGQLECVRWMVsetEAIAELS-CSKDFPSLIHYAGCYGQE 480
Cdd:COG0666   158 HLAAANGNLEIVKLLLEA-GAD-VNARDNDGETPLHLAAENGHLEIVKLLL---EAGADVNaKDNDGKTALDLAAENGNL 232

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1034646861 481 KILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYL 517
Cdd:COG0666   233 EIVKLLL----EAGADLNAKDKDGLTALLLAAAAGAA 265
Ank_4 pfam13637
Ankyrin repeats (many copies);
469-521 5.21e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.11  E-value: 5.21e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034646861 469 SLIHYAGCYGQEKILLWLLQFmqeqGISLDEVDQDGNSAVHVASQHGYLGCIQ 521
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEK----GADINAVDGNGETALHFAASNGNVEVLK 51
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
384-521 7.53e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 44.94  E-value: 7.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034646861 384 LAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAELSc 463
Cdd:COG0666     6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKD- 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034646861 464 sKDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGCIQ 521
Cdd:COG0666    85 -DGGNTLLHAAARNGDLEIVKLLL----EAGADVNARDKDGETPLHLAAYNGNLEIVK 137
Ank_4 pfam13637
Ankyrin repeats (many copies);
397-452 3.06e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.79  E-value: 3.06e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034646861 397 GNNLLHIAASQGHAECLQHLTSLmGEDClNERNTEKLTPAGLAIKNGQLECVRWMV 452
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEK-GADI-NAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
471-521 1.98e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.79  E-value: 1.98e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034646861 471 IHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGCIQ 521
Cdd:pfam12796   1 LHLAAKNGNLELVKLLL----ENGADANLQDKNGRTALHLAAKNGHLEIVK 47
Ank_5 pfam13857
Ankyrin repeats (many copies);
394-439 4.04e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.79  E-value: 4.04e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1034646861 394 DENGNNLLHIAASQGHAECLQHLtSLMGEDClNERNTEKLTPAGLA 439
Cdd:pfam13857  13 DGEGYTPLHVAAKYGALEIVRVL-LAYGVDL-NLKDEEGLTALDLA 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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