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Conserved domains on  [gi|1034641506|ref|XP_016864217|]
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homeodomain-only protein isoform X1 [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10052840)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

Gene Ontology:  GO:0003677|GO:0006357|GO:0043565
PubMed:  1357790|26464018|21557080

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 25-77 1.26e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 51.86  E-value: 1.26e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 1034641506 25 TEDQVEILEYNFNKvDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRRSE 77
Cdd:cd00086    8 TPEQLEELEKEFEK-NPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
 
Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 25-77 1.26e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 51.86  E-value: 1.26e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 1034641506 25 TEDQVEILEYNFNKvDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRRSE 77
Cdd:cd00086    8 TPEQLEELEKEFEK-NPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
24-75 1.73e-07

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 43.64  E-value: 1.73e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 1034641506 24 PTEDQVEILEYNFNKvDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRR 75
Cdd:pfam00046  7 FTPEQLEELEKEFQE-NPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 25-74 2.09e-07

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 43.39  E-value: 2.09e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034641506  25 TEDQVEILEYNFNKvDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWR 74
Cdd:smart00389  9 TPEQLEELEKEFQK-NPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
25-76 7.89e-04

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 35.88  E-value: 7.89e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034641506  25 TEDQVEILEYNFnKVDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRRS 76
Cdd:COG5576    59 TDEQLMVLEREF-EINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKK 109
 
Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 25-77 1.26e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 51.86  E-value: 1.26e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 1034641506 25 TEDQVEILEYNFNKvDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRRSE 77
Cdd:cd00086    8 TPEQLEELEKEFEK-NPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
24-75 1.73e-07

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 43.64  E-value: 1.73e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 1034641506 24 PTEDQVEILEYNFNKvDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRR 75
Cdd:pfam00046  7 FTPEQLEELEKEFQE-NPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 25-74 2.09e-07

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 43.39  E-value: 2.09e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034641506  25 TEDQVEILEYNFNKvDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWR 74
Cdd:smart00389  9 TPEQLEELEKEFQK-NPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
25-76 7.89e-04

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 35.88  E-value: 7.89e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034641506  25 TEDQVEILEYNFnKVDKHPDSTTLCLIAAEAGLSEEETQKWFKQRLAKWRRS 76
Cdd:COG5576    59 TDEQLMVLEREF-EINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKK 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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